HLA-C

Summary

Gene Symbol: HLA-C
Description: major histocompatibility complex, class I, C
Alias: D6S204, HLA-JY3, HLC-C, PSORS1, HLA class I histocompatibility antigen, C alpha chain, HLA class I histocompatibility antigen, Cw-1 alpha chain, MHC class I antigen heavy chain HLA-C, human leukocyte antigen-C alpha chain, major histocompatibility antigen HLA-C
Species: human

Top Publications

  1. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
  2. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
  3. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
  4. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
  5. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
  6. pmc Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
    Alasdair Leslie
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    J Virol 84:9879-88. 2010
  7. doi Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS 23:19-28. 2009
  8. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
  9. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
  10. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012

Detail Information

Publications250 found, 100 shown here

  1. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  2. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  3. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  4. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
    ..Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir...
  5. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
    ..Finally, we conclude that inhibiting the CD4 downregulation function is the most promising Nef-targeted approach for developing a new anti-viral as a contribution to combating AIDS...
  6. pmc Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
    Alasdair Leslie
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    J Virol 84:9879-88. 2010
    ..Taken together, these data suggest that although individual HLA alleles, particularly HLA-B, can have a strong impact, HIV control overall is likely to be influenced by the additive effect of some or all of the other HLA alleles present...
  7. doi Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS 23:19-28. 2009
    ....
  8. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    ..Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders...
  9. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  10. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
    ..The structure shows how Nef functions as a clathrin-associated sorting protein to alter the specificity of host membrane trafficking and enable viral evasion of adaptive immunity...
  11. pmc The emerging role of HLA-C in HIV-1 infection
    Deanna A Kulpa
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Immunology 134:116-22. 2011
    ..This review highlights these results and explores the ways in which HLA-C surface expression could affect immune system function in the setting of HIV disease...
  12. ncbi Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties
    K Maenaka
    Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 274:28329-34. 1999
    ..These results indicate that KIR/peptide-MHC class I interactions have properties typical of other cell-cell recognition molecules, and they highlight the unusual nature of TCR/peptide-MHC recognition...
  13. ncbi HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway
    Anastassia D Blagoveshchenskaya
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 111:853-66. 2002
    ..These data provide new insights into the cellular basis of HIV-1 immunoevasion...
  14. pmc Multiple Loci within the major histocompatibility complex confer risk of psoriasis
    Bing Jian Feng
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA
    PLoS Genet 5:e1000606. 2009
    ..These results demonstrate that there are at least two additional loci within the MHC conferring risk of psoriasis...
  15. pmc Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression
    Tumena W Corrah
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Virol 85:3367-74. 2011
    ..We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles...
  16. pmc HLA-class I markers and multiple sclerosis susceptibility in the Italian population
    L Bergamaschi
    Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Via Solaroli 17, Novara, Italy
    Genes Immun 11:173-80. 2010
    ..In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1*03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively...
  17. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
    ..Our results are consistent with an alternative model in which (62)EEEE(65) plays a stabilizing role in the formation of a ternary complex between Nef, the MHC-I cytoplasmic domain, and AP-1...
  18. doi Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
    Cheng Quan
    Department of Dermatology, No 2 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 42:614-8. 2010
    ..We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo...
  19. ncbi High-resolution HLA alleles and haplotypes in the United States population
    Martin Maiers
    National Marrow Donor Program, Minneapolis, Minnesota, USA
    Hum Immunol 68:779-88. 2007
    ..The electronic availability of this information will be useful for projects central to the typing and use of population data in HLA applications...
  20. ncbi KIR/HLA ligand incompatibility in kidney transplantation
    Kristina Kunert
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Transplantation 84:1527-33. 2007
    ..It has been suggested that KIR/HLA incompatibility exerts beneficial effects in hematopoietic stem cell transplantation...
  21. pmc HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation
    Ushani S Rajapaksa
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 109:13353-8. 2012
    ..We propose that the relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted CTLs...
  22. ncbi Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
    J C Boyington
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Nature 405:537-43. 2000
    ..A second KIR/HLA interface produced an ordered receptor-ligand aggregation in the crystal which may resemble receptor clustering during immune synapse formation...
  23. pmc HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
    ....
  24. ncbi HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    Hiroyuki Gatanaga
    AIDS 21:264-5. 2007
  25. pmc Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo
    Martha J Lewis
    Department of Medicine, Division of Infectious Diseases, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Virol 86:7126-35. 2012
    ..Overall, these data demonstrate that CTL pressure exerts a strong purifying selective pressure for MHC-I downregulation and identifies novel functional motifs present in Nef sequences in vivo...
  26. pmc HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    Malinda R Schaefer
    Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 4:e1000131. 2008
    ..The requirement for redundant motifs with distinct roles supports a model in which Nef exists in multiple conformational states that allow access to different motifs, depending upon which cellular target is bound by Nef...
  27. pmc HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 62:761-5. 2010
    ..008). These data support the involvement of the HLA-C locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR, but functional studies are essential to confirm this hypothesis...
  28. ncbi Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility
    D C Jones
    Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK
    Genes Immun 7:576-82. 2006
    ..019). These results suggest that KIR genotype and HLA ligand interaction may contribute to the genetic susceptibility of UC...
  29. pmc The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection
    Jolien Vermeire
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Belgium
    Curr HIV Res 9:474-89. 2011
    ..Hereby we aim to contribute to a better understanding of this highly conserved and therapeutically attractive Nef function...
  30. pmc HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
    Jolie A Leonard
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 85:6867-81. 2011
    ..These studies provide important new information on the similarities and differences with which Nef affects intracellular trafficking and help focus future research on the best potential pharmaceutical targets...
  31. pmc Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    H Akari
    Department of Virology, The University of Tokushima School of Medicine, Tokushima, Tokushima 770 8503, Japan
    J Virol 74:2907-12. 2000
    ....
  32. doi Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam at the Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS 25:2217-26. 2011
    ..Here we studied whether this increase coincides with a fading impact of above-mentioned host genetic markers on HIV-1 control...
  33. doi Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
    R D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, CA 90095 1652, USA
    Genes Immun 9:249-58. 2008
    ....
  34. ncbi Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  35. pmc The HLA-B/-C haplotype block contains major determinants for host control of HIV
    E Trachtenberg
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Genes Immun 10:673-7. 2009
    ....
  36. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
  37. doi Role of Nef in primate lentiviral immunopathogenesis
    F Kirchhoff
    Institute of Virology, University of Ulm, 89081 Ulm, Germany
    Cell Mol Life Sci 65:2621-36. 2008
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans...
  38. ncbi Distinct HLA-C/KIR genotype profile associates with guttate psoriasis
    Sofia J Holm
    Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Invest Dermatol 125:721-30. 2005
    ..In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections...
  39. doi Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage
    S E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Reprod 23:972-6. 2008
    ..Pre-eclampsia and recurrent miscarriage (RM) share the pathogenesis of defective placentation and therefore we have now genotyped couples with RM...
  40. ncbi HLA-C and guttate psoriasis
    E Mallon
    Tissue Typing Laboratory, Churchill Hospital, Oxford, U K
    Br J Dermatol 143:1177-82. 2000
    ..Guttate psoriasis is a specific clinical manifestation of psoriasis frequently associated with group A beta-haemolytic streptococcal throat infection...
  41. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
    ..Thus, Tat repression of MHC class I transcription would be one mechanism by which HIV avoids immune surveillance...
  42. ncbi Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C
    J Martinez-Borra
    Department of Immunology, Hospital Central de Asturias, Oviedo, Spain
    Rheumatology (Oxford) 42:1089-92. 2003
    ..To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis...
  43. doi Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis
    Yu Lian Jiao
    Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan 250021, People s Republic of China
    J Clin Immunol 30:840-4. 2010
    ....
  44. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  45. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV...
  46. pmc Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2 Canada
    J Virol 85:2828-36. 2011
    ..Hence, the capacity of HIV-1 to modulate MHC-I is not linked to its ability to integrate. Thus, Nef-mediated evasion of host immune responsiveness might be attributable, in part at least, to transcription from unintegrated viral DNA...
  47. doi Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania
    Rebecca N Koehler
    US Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Infect Dis 202:1562-6. 2010
    ..This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection...
  48. pmc Counteraction of HLA-C-mediated immune control of HIV-1 by Nef
    Anke Specht
    Institute of Molecular Virology, University Hospital of Ulm, Meyerhofstr 1, 89081 Ulm, Germany
    J Virol 84:7300-11. 2010
    ..Thus, while high HLA-C expression may generally facilitate control of HIV-1, Nef may counteract HLA-C-mediated immune control in some individuals indirectly, by manipulating T-cell function and MHC-II antigen presentation...
  49. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  50. pmc Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9629. 2010
    ..Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point...
  51. ncbi Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation
    Andreas Goldwich
    Institute of Clinical and Molecular Virology, Department of Dermatology, University Hospital of Erlangen, Germany
    J Immunol 180:372-82. 2008
    ..These results further underline the role of the defective ribosomal product pathway in adaptive immunity...
  52. pmc Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene
    Rajan P Nair
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0932, USA
    Am J Hum Genet 78:827-51. 2006
    Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC), to an approximately 300-kb region containing HLA-C and at least 10 other genes...
  53. doi HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms
    Y J Lin
    China Medical University Hospital, China Medical University, and Asia University, Taichung, Taiwan
    Arthritis Rheum 60:604-10. 2009
    ..The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population...
  54. ncbi Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules
    R Biassoni
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, Genova, Italy
    Eur J Immunol 27:3095-9. 1997
    ..1/p50.1 affinity for their HLA-C ligand and suggests a possible role of position 70 as a contact site in the natural killer cell receptor/major histocompatibility complex class I interaction...
  55. pmc Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa
    Zabrina Brumme
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
    Clin Infect Dis 49:956-64. 2009
    ....
  56. pmc The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    M E Greenberg
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 17:2777-89. 1998
    ....
  57. pmc Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
    Q R Fan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:7178-83. 1996
    ..The formation of complexes between soluble, recombinant molecules indicates that HLA-Cw4 is sufficient for specific ligation by the NK receptor and that neither glycoprotein requires carbohydrate for the interaction...
  58. doi Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Immunol 133:238-44. 2009
    ....
  59. pmc Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection
    Jun Zuo
    UCLA AIDS Institute and the David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    AIDS Res Hum Retroviruses 28:486-92. 2012
    ..Survival into adulthood with HIV infection acquired in infancy is not uniformly linked to loss of function in nef. The Nef protein remains a potential target for immunization or pharmacologic intervention...
  60. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  61. pmc Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone
    R P Johnson
    Infectious Disease Unit, Massachusetts General Hospital, Boston 02114
    J Virol 67:438-45. 1993
    ..In addition, the identification of an HLA-C molecule presenting viral antigen to CTL supports a functional role for these molecules...
  62. pmc HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX, USA
    PLoS ONE 3:e3636. 2008
    ....
  63. pmc The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR
    Giulia Matusali
    Laboratory of Immunoinfectivology, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    J Virol 86:4496-504. 2012
    ....
  64. pmc A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes
    Sayuki Iijima
    Laboratory of Disease Control, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Hachimandai, Tsukuba shi, Ibaraki, Japan
    J Virol 86:3944-51. 2012
    ..Our findings will help understanding of how HIV-1 evades the antiviral immune response by selectively redirecting the cellular protein trafficking system...
  65. pmc HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
    ..Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition...
  66. pmc Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    Pieter J Meuwissen
    Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, B 9000, Belgium
    Retrovirology 9:34. 2012
    ..In this study, we aimed to study the functional importance of this VGF region...
  67. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
    ..Further, mutation of the non-motif "X" residues, (Q73, V74, and L75) would give altered patterns of inhibition for different Nef/SH3 domain protein interactions...
  68. ncbi HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)
    A Steinle
    Institute of Immunology, University of Munich, Germany
    Tissue Antigens 44:268-70. 1994
  69. doi Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
    D S A Franceschi
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Maringa, Brazil
    Tissue Antigens 72:478-82. 2008
    ..Some KIR-HLA genotypes could be associated to the development of clinical forms of leprosy and should be investigated further...
  70. ncbi MICA 5.1 allele is a susceptibility marker for psoriasis in the Korean population
    H B Choi
    Catholic Hemopoietic Stem Cell Bank, Seoul, Korea
    Tissue Antigens 56:548-50. 2000
    ..1 allele might be a genetic marker related to the early onset of psoriasis and play a secondary role to the HLA-Cw*0602 gene or an unknown causative gene closely linked to HLA-Cw*0602 in the genetic susceptibility to psoriasis...
  71. doi Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation
    R Hanvesakul
    Department of Nephrology and Transplantation, University Hospital Birmingham, Edgbaston, Birmingham, UK
    Am J Transplant 8:1931-41. 2008
    ..Modulation of HLA-C and KIR interactions represents an important novel approach to promote long-term graft and patient survival...
  72. ncbi Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis
    A M Al-Heresh
    Royal National Hospital for Rheumatic Diseases and Department of Medical Sciences, University of Bath, Bath, UK
    Rheumatology (Oxford) 41:525-30. 2002
    ....
  73. ncbi Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    O Schwartz
    Laboratoire Rétrovirus et Transfert Génétique, Unité de Recherche Associée CNRS 1157, Paris, France
    Nat Med 2:338-42. 1996
    ..The stimulation of MHC-I endocytosis by Nef represents a previously undocumented viral mechanism for evading the immune response...
  74. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population...
  75. pmc Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
    Maya Williams
    Graduate Program in Cellular and Molecular Biology, University of Michigan University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Virol 76:12173-84. 2002
    ..In addition, they provide the first direct evidence indicating that Nef functions as an adaptor molecule able to link MHC-I to cellular trafficking proteins...
  76. ncbi Segregation of HLA-C from ICAM-1 at NK cell immune synapses is controlled by its cell surface density
    Catarina R Almeida
    Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    J Immunol 177:6904-10. 2006
    ..More broadly, segregation of proteins at intercellular contacts could transmit information about protein expression levels between cells...
  77. doi Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome
    David P Lowe
    Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Vincent Drive, Edgbaston, Birmingham, UK
    Rheumatology (Oxford) 48:359-62. 2009
    ....
  78. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface...
  79. ncbi Molecular diversity of the HLA-C gene identified in a caucasian population
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Northern, Belfast, Ireland
    Hum Immunol 63:602-13. 2002
    ..HLA-Cw allele frequencies occurring within the Northern Ireland population have been compiled, along with estimations of HLA-B/Cw haplotype frequencies...
  80. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
    ..Most of the amino acids that differ between human and chimpanzee KIRs with HLA-C specificities form solvent-accessible clusters outside the KIR-HLA interface, which suggests undiscovered interactions by KIRs...
  81. ncbi Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population
    S Gonzalez
    Functional Biology Department, University of Oviedo, Asturias, Spain
    Hum Immunol 62:632-8. 2001
    ..These results suggest that the MICA gene or other nearby gene(s) may be involved in the development of PsA, and it would thus appear that psoriasis vulgaris (PsV) and PsA are associated with different MHC susceptibility genes...
  82. doi KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA
    Hum Immunol 69:349-53. 2008
    ..The trends observed in this study are consistent with those reported for other autoimmune diseases...
  83. pmc Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs
    Wei Song
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7157. 2009
    ..In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM)...
  84. pmc ADAM33, a new candidate for psoriasis susceptibility
    Fabienne Lesueur
    Centre National de Genotypage, Evry, France
    PLoS ONE 2:e906. 2007
    ..In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13...
  85. ncbi Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
    Hum Genet 118:466-76. 2005
    ..Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago...
  86. ncbi Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005
    ..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians...
  87. ncbi MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist...
  88. ncbi Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations
    M Ameen
    St John s Institute of Dermatology, Kings College, London, UK
    Clin Exp Dermatol 30:414-8. 2005
    b>PSORS1 on chromosome 6p21.3, which contains the MHC, is a major susceptibility locus for psoriasis vulgaris...
  89. ncbi The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis
    Michael Hugh Allen
    St John s Institute of Dermatology, Kings College London, London, UK
    J Invest Dermatol 124:103-6. 2005
    b>PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major histocompatibility complex on chromosome 6p21.3...
  90. ncbi Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis
    John Foerster
    Klinik fur Dermatologie, Charite, Schumannstr, Berlin, Germany
    J Invest Dermatol 124:99-102. 2005
    The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2...
  91. ncbi The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population
    Jesus Martinez-Borra
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Invest Dermatol 125:928-32. 2005
    ..But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC)...
  92. ncbi Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients
    Johann E Gudjonsson
    National University Hospital of Iceland, Reykjavik
    J Invest Dermatol 126:740-5. 2006
    ..Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined...
  93. ncbi HLA Cw*06 is not essential for streptococcal-induced psoriasis
    L Fry
    Faculty of Medicine, Imperial College, London, UK, and The Skin Hospital, Dublin 2, Ireland
    Br J Dermatol 154:850-3. 2006
    ..Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form...
  94. ncbi Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan
    Am J Ophthalmol 143:367-8. 2007
    ..To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese...
  95. pmc HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  96. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  97. pmc Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population
    Xing Fan
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, Anhui, China
    PLoS Genet 4:e1000038. 2008
    b>PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested...
  98. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  99. ncbi Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients
    A C Biral
    Immunogenetic Transplant Laboratory, Clinical Pathology Department, School of Medical Science, Rua Gustavo Rodrigues Dória, 255, 13083 060 Campinas, SP, Brazil
    Eur J Dermatol 16:523-9. 2006
    ..Our results detected polymorphisms of the HLA class I and microsatellite TNF locus which could be markers of genetic predisposition to the disease...
  100. pmc A second major histocompatibility complex susceptibility locus for multiple sclerosis
    Tai Wai Yeo
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Neurol 61:228-36. 2007
    ..The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed...
  101. ncbi HLA alleles in pre-menopausal breast cancer patients from western India
    L Gopalkrishnan
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Khraghar, Navi Mumbai, India
    Indian J Med Res 124:305-12. 2006
    ..Therefore, we undertook this study to assess the possibility of association of HLA-class I alleles in pre-menopausal breast cancer patients...

Research Grants63

  1. MHC Class I and KIR Gene Evolution in Higher Primates
    Peter Parham; Fiscal Year: 2006
    ..This will test the hypothesis that orangutan is a species in which the HLA-C-mediated regulation of NK cells, which is dominant in humans, is at an intermediate stage of development. ..
  2. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2007
    ..Dr. Hsu intends to develop a career as an independent investigator in the field of NK cell immunogenetics and allogeneic hematopoietic stem cell transplantation. ..
  3. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
    ....
  4. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
    ....
  5. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2006
    ..This research will provide fundamental knowledge essential for future assessment of the role and importance of NK-cell receptor variation in human disease susceptibility and clinical transplantation. ..
  6. DOWN REGULATION OF HLA CLASS I IN HUMANS AND TUMORS
    Peter Parham; Fiscal Year: 2001
    ..The experiments of Aim 3 will focus on understanding the mechanisms controlling HLA class I mRNA splicing and the levels of cytoplasmic mRNA. The hypothesis that exon 3 contains an enhancer of mRNA splicing will be tested. ..
  7. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2010
    ..The overall significance of this study is to provide insight into the mechanism important for allowing HIV to counter cellular immune responses that are differentially regulated by MHC class I molecules. ..
  8. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2009
    ..The overall significance of this study is to provide insight into the mechanism important for allowing HIV to counter cellular immune responses that are differentially regulated by MHC class I molecules. ..
  9. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2000
    ....
  10. THE NATURE AND FUNCTION OF HLA-A,B,C POLYMORPHISM
    Peter Parham; Fiscal Year: 1993
    ..It will also lay the foundation for absolute definition of class I HLA type, thereby facilitating development of accurate typing and more incisive analysis of human immunology, human genetics and of tissue match in transplantation...
  11. High Resolution Multiplexed DNA reverse-SSO Typing Assay
    Jar How Lee; Fiscal Year: 2007
    ..Following validation testing and regulatory clearance, a complete line of superior HLA and KIR typing products will be available to the NMDP and HLA laboratories. ..
  12. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2010
    ....
  13. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2010
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  14. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2011
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  15. High Performance Magnetic Cell Sorting
    JEFFREY CHALMERS; Fiscal Year: 2006
    ..abstract_text> ..
  16. NK/DC Cross-Talk and Antiviral Response
    Luis Montaner; Fiscal Year: 2009
    ..As the rate of response to therapy varies from about 60% in mono-infection to <25% in HIV/HCV co-infected individuals, it is imperative that added research be conducted in understanding clearance mechanisms. ..
  17. NK/DC Cross-Talk and Antiviral Response
    Luis J Montaner; Fiscal Year: 2010
    ..As the rate of response to therapy varies from about 60% in mono-infection to <25% in HIV/HCV co-infected individuals, it is imperative that added research be conducted in understanding clearance mechanisms. ..
  18. Custon Designing Peptides for Cancer Immunotherapy
    Douglas Lake; Fiscal Year: 2005
    ..In future studies, we intend to expand this multi-allelic approach to include other tumor associated antigens. ..