HLA-C

Summary

Gene Symbol: HLA-C
Description: major histocompatibility complex, class I, C
Alias: D6S204, HLA-JY3, HLC-C, PSORS1, HLA class I histocompatibility antigen, C alpha chain, HLA class I histocompatibility antigen, Cw-1 alpha chain, MHC class I antigen heavy chain HLA-C, human leukocyte antigen-C alpha chain, major histocompatibility antigen HLA-C
Species: human

Top Publications

  1. ncbi Thalidomide does not perturb CD2, CD4, CD5, CD8, HLA-DR, or HLA-A, B, C molecules in vitro on the membranes of cells with immune potential
    E J Shannon
    Gillis W. Long Hansen's Disease Center, Laboratory Research Branch, Louisiana State University, Baton Rouge
    Immunopharmacol Immunotoxicol 16:717-29. 1994
  2. ncbi The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles
    V K Prasad
    Department of Pediatrics, Biochemical Immunogenetics Laboratory, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Transplantation 68:1044-50. 1999
  3. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
  4. ncbi A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
  5. ncbi A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
  6. ncbi Multiple Loci within the major histocompatibility complex confer risk of psoriasis
    Bing Jian Feng
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA
    PLoS Genet 5:e1000606. 2009
  7. ncbi HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
  8. ncbi Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
    Cheng Quan
    Department of Dermatology, No 2 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 42:614-8. 2010
  9. ncbi High-resolution HLA alleles and haplotypes in the United States population
    Martin Maiers
    National Marrow Donor Program, Minneapolis, Minnesota, USA
    Hum Immunol 68:779-88. 2007
  10. ncbi HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX, USA
    PLoS ONE 3:e3636. 2008

Research Grants

  1. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2007
  2. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
  3. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
  4. DOWN REGULATION OF HLA CLASS I IN HUMANS AND TUMORS
    Peter Parham; Fiscal Year: 2001
  5. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2006
  6. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2010
  7. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2009
  8. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2000
  9. THE NATURE AND FUNCTION OF HLA-A,B,C POLYMORPHISM
    Peter Parham; Fiscal Year: 1993
  10. MHC Class I and KIR Gene Evolution in Higher Primates
    Peter Parham; Fiscal Year: 2006

Detail Information

Publications208 found, 100 shown here

  1. ncbi Thalidomide does not perturb CD2, CD4, CD5, CD8, HLA-DR, or HLA-A, B, C molecules in vitro on the membranes of cells with immune potential
    E J Shannon
    Gillis W. Long Hansen's Disease Center, Laboratory Research Branch, Louisiana State University, Baton Rouge
    Immunopharmacol Immunotoxicol 16:717-29. 1994
    ..Thalidomide did not modify: (a) adhesion and/or signal transducing molecules such as CD2, CD4, CD5 and CD8, or (b) molecules that facilitate antigen presentation such as HLA-DR, HLA-A, HLA-B, or HLA-C...
  2. ncbi The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles
    V K Prasad
    Department of Pediatrics, Biochemical Immunogenetics Laboratory, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Transplantation 68:1044-50. 1999
    ..In this study, we determine the LD between HLA-B and -C alleles and estimate the probability of molecular HLA-C matching between unrelated individuals who match for both HLA-B alleles...
  3. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  4. ncbi A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  5. ncbi A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
  6. ncbi Multiple Loci within the major histocompatibility complex confer risk of psoriasis
    Bing Jian Feng
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA
    PLoS Genet 5:e1000606. 2009
    ..These results demonstrate that there are at least two additional loci within the MHC conferring risk of psoriasis...
  7. ncbi HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
    ..Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition...
  8. ncbi Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
    Cheng Quan
    Department of Dermatology, No 2 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 42:614-8. 2010
    ..We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo...
  9. ncbi High-resolution HLA alleles and haplotypes in the United States population
    Martin Maiers
    National Marrow Donor Program, Minneapolis, Minnesota, USA
    Hum Immunol 68:779-88. 2007
    ..The electronic availability of this information will be useful for projects central to the typing and use of population data in HLA applications...
  10. ncbi HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, TX, USA
    PLoS ONE 3:e3636. 2008
    ....
  11. ncbi Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis
    A M Al-Heresh
    Royal National Hospital for Rheumatic Diseases and Department of Medical Sciences, University of Bath, Bath, UK
    Rheumatology (Oxford) 41:525-30. 2002
    ....
  12. ncbi Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
    R D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, CA 90095 1652, USA
    Genes Immun 9:249-58. 2008
    ....
  13. ncbi Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  14. ncbi Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage
    S E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Reprod 23:972-6. 2008
    ..Pre-eclampsia and recurrent miscarriage (RM) share the pathogenesis of defective placentation and therefore we have now genotyped couples with RM...
  15. ncbi Distinct HLA-C/KIR genotype profile associates with guttate psoriasis
    Sofia J Holm
    Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Invest Dermatol 125:721-30. 2005
    ..In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections...
  16. ncbi HLA-C and guttate psoriasis
    E Mallon
    Tissue Typing Laboratory, Churchill Hospital, Oxford, U K
    Br J Dermatol 143:1177-82. 2000
    ..Guttate psoriasis is a specific clinical manifestation of psoriasis frequently associated with group A beta-haemolytic streptococcal throat infection...
  17. ncbi HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms
    Y J Lin
    China Medical University Hospital, China Medical University, and Asia University, Taichung, Taiwan
    Arthritis Rheum 60:604-10. 2009
    ..The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population...
  18. ncbi Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene
    Rajan P Nair
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0932, USA
    Am J Hum Genet 78:827-51. 2006
    Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC), to an approximately 300-kb region containing HLA-C and at least 10 other genes...
  19. ncbi Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules
    R Biassoni
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, Genova, Italy
    Eur J Immunol 27:3095-9. 1997
    ..1/p50.1 affinity for their HLA-C ligand and suggests a possible role of position 70 as a contact site in the natural killer cell receptor/major histocompatibility complex class I interaction...
  20. ncbi Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa
    Zabrina Brumme
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
    Clin Infect Dis 49:956-64. 2009
    ....
  21. ncbi MICA 5.1 allele is a susceptibility marker for psoriasis in the Korean population
    H B Choi
    Catholic Hemopoietic Stem Cell Bank, Seoul, Korea
    Tissue Antigens 56:548-50. 2000
    ..1 allele might be a genetic marker related to the early onset of psoriasis and play a secondary role to the HLA-Cw*0602 gene or an unknown causative gene closely linked to HLA-Cw*0602 in the genetic susceptibility to psoriasis...
  22. ncbi Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis
    Yu Lian Jiao
    Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan 250021, People s Republic of China
    J Clin Immunol 30:840-4. 2010
    ....
  23. ncbi Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
    D S A Franceschi
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Maringa, Brazil
    Tissue Antigens 72:478-82. 2008
    ..Some KIR-HLA genotypes could be associated to the development of clinical forms of leprosy and should be investigated further...
  24. ncbi KIR/HLA ligand incompatibility in kidney transplantation
    Kristina Kunert
    Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Transplantation 84:1527-33. 2007
    ..It has been suggested that KIR/HLA incompatibility exerts beneficial effects in hematopoietic stem cell transplantation...
  25. ncbi Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation
    R Hanvesakul
    Department of Nephrology and Transplantation, University Hospital Birmingham, Edgbaston, Birmingham, UK
    Am J Transplant 8:1931-41. 2008
    ..Modulation of HLA-C and KIR interactions represents an important novel approach to promote long-term graft and patient survival...
  26. ncbi HLA-class I markers and multiple sclerosis susceptibility in the Italian population
    L Bergamaschi
    Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Via Solaroli 17, Novara, Italy
    Genes Immun 11:173-80. 2010
    ..In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1*03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively...
  27. ncbi Segregation of HLA-C from ICAM-1 at NK cell immune synapses is controlled by its cell surface density
    Catarina R Almeida
    Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    J Immunol 177:6904-10. 2006
    ..More broadly, segregation of proteins at intercellular contacts could transmit information about protein expression levels between cells...
  28. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV...
  29. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
    ..Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir...
  30. ncbi Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome
    David P Lowe
    Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Vincent Drive, Edgbaston, Birmingham, UK
    Rheumatology (Oxford) 48:359-62. 2009
    ....
  31. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
    ..Most of the amino acids that differ between human and chimpanzee KIRs with HLA-C specificities form solvent-accessible clusters outside the KIR-HLA interface, which suggests undiscovered interactions by KIRs...
  32. ncbi Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population
    S Gonzalez
    Functional Biology Department, University of Oviedo, Asturias, Spain
    Hum Immunol 62:632-8. 2001
    ..These results suggest that the MICA gene or other nearby gene(s) may be involved in the development of PsA, and it would thus appear that psoriasis vulgaris (PsV) and PsA are associated with different MHC susceptibility genes...
  33. ncbi Molecular diversity of the HLA-C gene identified in a caucasian population
    Fionnuala Williams
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Northern, Belfast, Ireland
    Hum Immunol 63:602-13. 2002
    ..HLA-Cw allele frequencies occurring within the Northern Ireland population have been compiled, along with estimations of HLA-B/Cw haplotype frequencies...
  34. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface...
  35. ncbi KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA
    Hum Immunol 69:349-53. 2008
    ..The trends observed in this study are consistent with those reported for other autoimmune diseases...
  36. ncbi Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples
    M Tevfik Dorak
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Lancet 363:2137-9. 2004
    ..23, 95% CI 1.52-3.26, p<0.0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections...
  37. ncbi Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
    Hum Genet 118:466-76. 2005
    ..Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago...
  38. ncbi Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs
    Wei Song
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7157. 2009
    ..In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM)...
  39. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  40. ncbi Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci
    K Cao
    Department of Oncology, Georgetown University, Washington, DC, USA
    Tissue Antigens 63:293-325. 2004
    ....
  41. ncbi Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans
    Xue Jun Zhang
    Institute of Dermatology, Anhui Medical University, No 69 Meishan Road, Hefei, Anhui 230032, PR China
    J Dermatol Sci 33:1-6. 2003
    ..Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis...
  42. ncbi HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    J Invest Dermatol 121:1360-4. 2003
    We have previously shown that HCR is a good candidate gene for psoriasis based on its location in the PSORS1 locus, predicted secondary structure change of the associated allele, and expression pattern...
  43. ncbi Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding
    Mathias Faure
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Immunol 170:6107-14. 2003
    ..The unique property of KIR to become phosphorylated in the absence of adhesion and of actin cytoskeleton rearrangement explains how KIR can efficiently block early activation signals during NK-target cell contacts...
  44. ncbi Human leukocyte antigen-A, -B, and -Cw polymorphism in a Berber population from North Morocco using sequence-based typing
    D Piancatelli
    C N R Istituto per i Trapianti d Organo e l Immunocitologia, L Aquila, Italy
    Tissue Antigens 63:158-72. 2004
    ..Nevertheless, this study highlights some unique genetic traits of the ME population compared to other ethnic groups within Morocco, which could be of great interest for clinical aims, transplantation, and diseases...
  45. ncbi The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos
    T L Bugawan
    Department of Human Genetics, Roche Molecular Systems, Alameda, CA 94501, USA
    Tissue Antigens 59:452-69. 2002
    ..Thus, specific HLA class I-A and C alleles were associated with type 1 diabetes in the Filipinos and may, in combination with high risk DR-DQ haplotypes, significantly modify disease risk...
  46. ncbi Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus
    Colin D Veal
    Division of Medical Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Am J Hum Genet 71:554-64. 2002
    ..Genomewide scans for disease susceptibility have repeatedly demonstrated the existence of a major locus, PSORS1 (psoriasis susceptibility 1), contained within the major histocompatibility complex (MHC), on chromosome 6p21...
  47. ncbi The HLA-B/-C haplotype block contains major determinants for host control of HIV
    E Trachtenberg
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Genes Immun 10:673-7. 2009
    ....
  48. ncbi The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Hum Immunol 65:1506-15. 2004
    ..These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population...
  49. ncbi Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis
    John Foerster
    Klinik fur Dermatologie, Charite, Schumannstr, Berlin, Germany
    J Invest Dermatol 124:99-102. 2005
    The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2...
  50. ncbi HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  51. ncbi HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    Soranun Chantarangsu
    Research Group for Pharmacogenomics, RIKEN, Center for Genomic Medicine, Tokyo, Japan
    Pharmacogenet Genomics 19:139-46. 2009
    ..Investigation of a possible involvement of differences in human leukocyte antigens (HLA) in the risk of nevirapine (NVP)-induced skin rash among HIV-infected patients...
  52. ncbi A second major histocompatibility complex susceptibility locus for multiple sclerosis
    Tai Wai Yeo
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Neurol 61:228-36. 2007
    ..The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed...
  53. ncbi Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan
    Am J Ophthalmol 143:367-8. 2007
    ..To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese...
  54. ncbi Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:2626-35. 2008
    ..Thus, HLA class I gene products not only mediate HIV-1 pathogenesis and evolution but also influence heterosexual HIV-1 transmission...
  55. ncbi ADAM33, a new candidate for psoriasis susceptibility
    Fabienne Lesueur
    Centre National de Genotypage, Evry, France
    PLoS ONE 2:e906. 2007
    ..In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13...
  56. ncbi Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  57. ncbi Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population
    Xing Fan
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, Anhui, China
    PLoS Genet 4:e1000038. 2008
    b>PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested...
  58. ncbi HLA alleles in pre-menopausal breast cancer patients from western India
    L Gopalkrishnan
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Khraghar, Navi Mumbai, India
    Indian J Med Res 124:305-12. 2006
    ..Therefore, we undertook this study to assess the possibility of association of HLA-class I alleles in pre-menopausal breast cancer patients...
  59. ncbi HLA Cw*06 is not essential for streptococcal-induced psoriasis
    L Fry
    Faculty of Medicine, Imperial College, London, UK, and The Skin Hospital, Dublin 2, Ireland
    Br J Dermatol 154:850-3. 2006
    ..Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form...
  60. ncbi The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis
    Michael Hugh Allen
    St John s Institute of Dermatology, Kings College London, London, UK
    J Invest Dermatol 124:103-6. 2005
    b>PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major histocompatibility complex on chromosome 6p21.3...
  61. ncbi Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients
    A C Biral
    Immunogenetic Transplant Laboratory, Clinical Pathology Department, School of Medical Science, Rua Gustavo Rodrigues Dória, 255, 13083 060 Campinas, SP, Brazil
    Eur J Dermatol 16:523-9. 2006
    ..Our results detected polymorphisms of the HLA class I and microsatellite TNF locus which could be markers of genetic predisposition to the disease...
  62. ncbi Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations
    M Ameen
    St John s Institute of Dermatology, Kings College, London, UK
    Clin Exp Dermatol 30:414-8. 2005
    b>PSORS1 on chromosome 6p21.3, which contains the MHC, is a major susceptibility locus for psoriasis vulgaris...
  63. ncbi MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist...
  64. ncbi Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005
    ..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians...
  65. ncbi HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  66. ncbi The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population
    Jesus Martinez-Borra
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Invest Dermatol 125:928-32. 2005
    ..But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC)...
  67. ncbi Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients
    Johann E Gudjonsson
    National University Hospital of Iceland, Reykjavik
    J Invest Dermatol 126:740-5. 2006
    ..Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined...
  68. ncbi Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients
    Hsien Tzung Liao
    Taipei Medical University, Municipal Wan Fang Hospital, Hualien, Taiwan
    J Rheumatol 35:891-5. 2008
    ..We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis...
  69. ncbi Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus
    Kati Asumalahti
    Department of Medical Genetics and Finnish Genome Center, University of Helsinki, 00014 Helsinki, Finland
    Hum Mol Genet 11:589-97. 2002
    b>PSORS1, near HLA-C, is the major genetic determinant of psoriasis. We present genetic and structural evidence suggesting a major role for the HCR gene at the PSORS1 locus...
  70. ncbi Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C
    J Zemmour
    Department of Cell Biology, Stanford University, California 94305
    J Exp Med 176:937-50. 1992
    ..The overall picture HLA-C polymorphism obtained from this sampling of HLA-C alleles is unlikely to change as further alleles are characterized...
  71. ncbi HLA polymorphism in the Murcia population (Spain): in the cradle of the archaeologic Iberians
    M Muro
    Service of Immunology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Hum Immunol 62:910-21. 2001
    ..Thus, Murcian population seems to belong to the European genetic pool, revealing a lesser genetic distance with the North Africans and the rest of populations from the Iberian Peninsula...
  72. ncbi Differential expression of human major histocompatibility class I loci: HLA-A, -B, and -C
    D R Johnson
    Department of Pathology and the Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Hum Immunol 61:389-96. 2000
    ..Differential expression of these HLA class I loci may contribute to cell-type dependent immune reactions by preferentially presenting distinct peptides to T cells...
  73. ncbi A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach
    L Samuelsson
    Department of Clinical Genetics, Goteborg University, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Hum Genet 105:523-9. 1999
    ..In addition, confirmation of previously reported loci was established on chromosomes 4q, 6p, and 17q. This study indicates that distinct disease loci might be involved in psoriasis etiology for various phenotypes...
  74. ncbi Enhanced HIV infectivity and changes in GP120 conformation associated with viral incorporation of human leucocyte antigen class I molecules
    A Cosma
    Centre Intégré de Recherches Biocliniques sur le SIDA, Paris, France
    AIDS 13:2033-42. 1999
    ..Virion-associated HLA class II and intercellular adhesion molecule-1 enhance the infectivity of T-cell line-adapted (TCLA) viruses. No role for virion-associated HLA class I molecules has yet been identified...
  75. ncbi Repression of MHC class I gene promoter activity by two-exon Tat of HIV
    T K Howcroft
    Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892
    Science 260:1320-2. 1993
    ..These studies define an activity for two-exon Tat distinct from that of one-exon Tat and suggest a mechanism whereby HIV-1-infected cells might be able to avoid immune surveillance, allowing the virus to persist in the infected host...
  76. ncbi Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction
    A Neisig
    Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    J Immunol 160:171-9. 1998
    ..The restricted peptide binding of certain HLA-C alleles provides one explanation for the reduced expression of HLA-C molecules at the cell surface. Other mechanisms will be discussed...
  77. ncbi HLA-Cw*04 and hepatitis C virus persistence
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, USA
    J Virol 76:4792-7. 2002
    ..Further investigation is needed to understand the relationship between class I alleles and HCV clearance...
  78. ncbi Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
    R C Trembath
    Department of Genetics, University of Leicester, UK
    Hum Mol Genet 6:813-20. 1997
    ....
  79. ncbi Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone
    R P Johnson
    Infectious Disease Unit, Massachusetts General Hospital, Boston 02114
    J Virol 67:438-45. 1993
    ..In addition, the identification of an HLA-C molecule presenting viral antigen to CTL supports a functional role for these molecules...
  80. ncbi Distinctive KIR and HLA diversity in a panel of north Indian Hindus
    Raja Rajalingam
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    Immunogenetics 53:1009-19. 2002
    ..All 72 members of the north Indian panel have different HLA genotype and different KIR genotype...
  81. ncbi Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains
    F Grassi
    Dipartimento di Biologia e Genetica per le Scienze Mediche, Universita di Milano, Italy
    J Exp Med 174:53-62. 1991
    ....
  82. ncbi Low-cost, simultaneous, single-sequence genotyping of the HLA-A, HLA-B and HLA-C loci
    W G H Abbott
    New Zealand Liver Transplant Unit, Auckland Hospital, Private Bag 92 024, Auckland, New Zealand
    Tissue Antigens 68:28-37. 2006
    ..In summary, we are describing a low-cost, sequencing assay for the three major HLA class I loci that provides a level of resolution that is comparable with a commercial PCR-SSP assay...
  83. ncbi Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction
    Francesco Puppo
    Department of Internal Medicine DIMI, Viale Benedetto XV, N 6, 16132 Genoa, Italy
    ScientificWorldJournal 2:421-3. 2002
    ..Taken together, these data suggest that sHLA-I molecules are involved in a signal-transduction pathway leading to Fas-ligand expression, soluble Fas-ligand secretion, and CD8+ cells apoptosis...
  84. ncbi Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus
    E J Adams
    Departments of Structural Biology and Microbiology and Immunology, Sherman Fairchild Building, Stanford University School of Medicine Stanford, CA 94305 5400, USA
    Immunogenetics 49:865-71. 1999
    ..These results raise the possibilities that other primate species have a C locus and that the regulation of natural killer cells by C allotypes evolved earlier in primate evolution than has been thought...
  85. ncbi Molecular mapping of a new public HLA class I epitope shared by all HLA-B and HLA-C antigens and defined by a monoclonal antibody
    J A Trapani
    Laboratory of Human Immunogenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Immunogenetics 29:25-32. 1989
    ..These observations are consistent with the notion that gln-144 and arg-151 define a determinant common to HLA-B, HLA-C, and the HLA-Aw19 cross-reactive group and the binding site of the monoclonal antibody 4E...
  86. ncbi Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles
    A Moretta
    Istituto di Istologia ed Embriologia Generale, Universita di Genova, Italy
    J Exp Med 180:545-55. 1994
    ..Finally, we show that Kp43 molecules function as receptors only for some HLA-B alleles and that still undefined receptor(s) must exist for other HLA-B alleles including B27...
  87. ncbi Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality
    Nompumelelo Mkhwanazi
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
    Virology 405:483-91. 2010
    ..Furthermore, sequence variation does not appear to significantly impact CD8+ T cell polyfunctionality in chronic HIV-1 infection...
  88. ncbi Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*0602-B*5701 in German families
    M Schmitt-Egenolf
    Department of Dermatology, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Tissue Antigens 57:440-6. 2001
    ..This lack of three-locus interaction is suggestive of two independent genetic contributions to psoriasis within the major histocompatibility complex (MHC)...
  89. ncbi Analysis of 250 HLA-B44 genotypes in European Caucasoids: high diversity and preferential ABCDRB1 associations in B*4402, B*4403, and B*4405 haplotypes
    J M Tiercy
    National Reference Laboratory for Histocompatibility, Transplantation Immunology Unit, Division of Immunology and Allergology, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 4, Switzerland
    Tissue Antigens 65:429-36. 2005
    ..HLA-C incompatibility rate was 22.2% for the patients with > or =1 B44 allele-matched donor(s). This dataset can therefore be used as a predictive tool for B44- and C-disparities in unrelated stem cell transplantation...
  90. ncbi Comparison between two human endogenous retrovirus (HERV)-rich regions within the major histocompatibility complex
    J K Kulski
    Centre for Molecular Immunology and Instrumentation, University of Western Australia, Faculty of Medicine and Dentistry, P O Box 5100, Canning Vale, 6155, Western Australia, Australia
    J Mol Evol 48:675-83. 1999
    ..These HERV sequences will therefore enhance further studies on disease associations and differences between human haplotypes and primates and their role in the evolution of class I genes in the MHC...
  91. ncbi How Does the maternal immune system contribute to the development of pre-eclampsia?
    A Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 28:S51-6. 2007
    ..The academic excitement of this work is the realisation that this is a novel form of allorecognition based on NK cells that operates entirely differently from self/non-self discrimination used by T cells...
  92. ncbi The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 zeta chain, Fc epsilon RI gamma chain and the p56lck kinase
    C Bottino
    Instituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 24:2527-34. 1994
    ..Finally, the anti-p58-mediated inhibition of the NK cell triggering via CD16 molecules was not accompanied by a down-regulation of the tyrosine phosphorylation of the CD16-associated CD3 zeta chains...
  93. ncbi Role of the inhibitory KIR ligand HLA-Bw4 and HLA-C expression levels in the recognition of leukemic cells by Natural Killer cells
    Sonja Verheyden
    Department of Hematology, HLA and Molecular Hematology Laboratory, Universitair Ziekenhuis Brussel UZ Brussel, Brussels, Belgium
    Cancer Immunol Immunother 58:855-65. 2009
    ..Our results suggest that besides the HLA and KIR genotype, expression levels of KIR ligands on leukemic cells should be included among the criteria used to select the donor-recipient combinations for HSCT...
  94. ncbi A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
    C Bottino
    Istituto Scientifico Tumori, Genova, Italy
    Eur J Immunol 26:1816-24. 1996
    ....
  95. ncbi Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals
    Elissaveta Naumova
    Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, 1, G Sofiiski St, Sofia, 1431, Bulgaria
    Cancer Immunol Immunother 54:172-8. 2005
    ....
  96. ncbi HLA-C mismatches induce strong cytotoxic T-cell reactivity in the presence of an additional DRB/DQB mismatch and affect NK cell-mediated alloreactivity
    A van der Meer
    Department for Blood Transfusion and Transplantation Immunology, University Medical Center St Radboud Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Transplantation 72:923-9. 2001
    ..In the current study we provide an in vitro basis to address the question of whether mismatches for this antigen are a risk factor for acute graft-versus-host disease (GVHD)...
  97. ncbi High resolution HLA-C typing by PCR-SSP: identification of allelic frequencies and linkage disequilibria in 604 unrelated random UK Caucasoids and a comparison with serology
    M Bunce
    Nuffield Department of Surgery, Oxford Transplant Centre, Churchill Hospital, United Kingdom
    Tissue Antigens 50:100-11. 1997
    ..The overall discrepancy rate between serology and SSP was high at 37% (195/527). High-resolution HLA-C typing of 112 International Histocompatibility Workshop cell lines has also been performed...
  98. ncbi Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C
    Alon Herschhorn
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Immunol 185:7623-32. 2010
    ..Abs and pseudoviruses with such specificity are likely to be highly valuable as building blocks for specific targeting and killing of HIV-1-infected cells...
  99. ncbi A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis
    Y T Chang
    Department of Dermatology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan, Republic of China
    Br J Dermatol 148:418-23. 2003
    ..However, the information about their role in psoriasis in Chinese patients is limited...
  100. ncbi HLA-B51 and haplotypic diversity of B-Cw associations: implications for matching in unrelated hematopoietic stem cell transplantation
    F Bettens
    Transplantation Immunology Unit, National Reference Laboratory for Histocompatibility, University Hospital, 24 Rue Micheli du Crest, Geneva, Switzerland
    Tissue Antigens 73:316-25. 2009
    ..HLA-B51 haplotypes therefore exhibit a high diversity at the level of B-Cw associations and of non-HLA polymorphisms in the class I and III regions. Such heterogeneity negatively impacts on overall matching in HSCT...
  101. ncbi Expression of HLA-C-specific natural killer cell receptors (CD158a and CD158b) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation
    J Tanaka
    Haematology and Oncology Third Department of Internal Medicine Transfusion Medicine Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Haematol 108:778-83. 2000
    ..7% respectively; P < 0.05). The exact clinical relevance of these CD158b-expressing cells is not clear. However, there is an interesting possibility that CD158b-expressing cells play some role in the regulation of GVHD after allo-BMT...

Research Grants63

  1. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2007
    ..Dr. Hsu intends to develop a career as an independent investigator in the field of NK cell immunogenetics and allogeneic hematopoietic stem cell transplantation. ..
  2. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
    ....
  3. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    RICHARD ALAN KASLOW; Fiscal Year: 2010
    ....
  4. DOWN REGULATION OF HLA CLASS I IN HUMANS AND TUMORS
    Peter Parham; Fiscal Year: 2001
    ..The experiments of Aim 3 will focus on understanding the mechanisms controlling HLA class I mRNA splicing and the levels of cytoplasmic mRNA. The hypothesis that exon 3 contains an enhancer of mRNA splicing will be tested. ..
  5. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2006
    ..This research will provide fundamental knowledge essential for future assessment of the role and importance of NK-cell receptor variation in human disease susceptibility and clinical transplantation. ..
  6. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2010
    ..The overall significance of this study is to provide insight into the mechanism important for allowing HIV to counter cellular immune responses that are differentially regulated by MHC class I molecules. ..
  7. Role of HLA-G on HIV Evasion of NK Cells
    Edward Barker; Fiscal Year: 2009
    ..The overall significance of this study is to provide insight into the mechanism important for allowing HIV to counter cellular immune responses that are differentially regulated by MHC class I molecules. ..
  8. INTERACTIONS BETWEEN HLA CLASS I & CYTOLYTIC LYMPHOCYTES
    Peter Parham; Fiscal Year: 2000
    ....
  9. THE NATURE AND FUNCTION OF HLA-A,B,C POLYMORPHISM
    Peter Parham; Fiscal Year: 1993
    ..It will also lay the foundation for absolute definition of class I HLA type, thereby facilitating development of accurate typing and more incisive analysis of human immunology, human genetics and of tissue match in transplantation...
  10. MHC Class I and KIR Gene Evolution in Higher Primates
    Peter Parham; Fiscal Year: 2006
    ..This will test the hypothesis that orangutan is a species in which the HLA-C-mediated regulation of NK cells, which is dominant in humans, is at an intermediate stage of development. ..
  11. High Resolution Multiplexed DNA reverse-SSO Typing Assay
    Jar How Lee; Fiscal Year: 2007
    ..Following validation testing and regulatory clearance, a complete line of superior HLA and KIR typing products will be available to the NMDP and HLA laboratories. ..
  12. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2010
    ....
  13. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2010
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  14. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2011
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  15. High Performance Magnetic Cell Sorting
    JEFFREY CHALMERS; Fiscal Year: 2006
    ..abstract_text> ..
  16. NK/DC Cross-Talk and Antiviral Response
    Luis Montaner; Fiscal Year: 2009
    ..As the rate of response to therapy varies from about 60% in mono-infection to <25% in HIV/HCV co-infected individuals, it is imperative that added research be conducted in understanding clearance mechanisms. ..
  17. NK/DC Cross-Talk and Antiviral Response
    Luis J Montaner; Fiscal Year: 2010
    ..As the rate of response to therapy varies from about 60% in mono-infection to <25% in HIV/HCV co-infected individuals, it is imperative that added research be conducted in understanding clearance mechanisms. ..
  18. Custon Designing Peptides for Cancer Immunotherapy
    Douglas Lake; Fiscal Year: 2005
    ..In future studies, we intend to expand this multi-allelic approach to include other tumor associated antigens. ..