Gene Symbol: HIVEP1
Description: human immunodeficiency virus type I enhancer binding protein 1
Alias: CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, zinc finger protein 40, cirhin interaction protein, gate keeper of apoptosis-activating protein, major histocompatibility complex binding protein 1, positive regulatory domain II binding factor 1
Species: human
Products:     HIVEP1

Top Publications

  1. Denisenko E, Guler R, Mhlanga M, Suzuki H, Brombacher F, Schmeier S. Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection. BMC Genomics. 2019;20:71 pubmed publisher
    ..tb infection, such as Fbxl3, Tapt1, Edn1, and Hivep1. Our findings suggest the importance of macrophage host transcriptional enhancers during M.tb infection...
  2. Liu Z, Zhang A, Zheng L, Johnathan A, Zhang J, Zhang G. The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1). Int J Mol Sci. 2018;19: pubmed publisher
  3. Xie F, Chen X, Weng S, Xia T, Sun X, Luo T, et al. Effects of two environmental endocrine disruptors di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) on human sperm functions in vitro. Reprod Toxicol. 2019;83:1-7 pubmed publisher
    ..Our findings indicate that DBP and MBP may compromise human sperm functions by inhibiting sperm tyrosine phosphorylation once they accumulate in semen at high levels. ..
  4. Gong P, Chen S, Zhang L, Hu Y, Gu A, Zhang J, et al. RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells. Environ Sci Pollut Res Int. 2018;25:35440-35450 pubmed publisher
    ..This study suggests that MBP can reduce the phagocytosis of Sertoli cells through RhoG-ELMO1-RAC1 pathway. ..
  5. Babrak L, Danelishvili L, Rose S, Kornberg T, Bermudez L. The environment of "Mycobacterium avium subsp. hominissuis" microaggregates induces synthesis of small proteins associated with efficient infection of respiratory epithelial cells. Infect Immun. 2015;83:625-36 pubmed publisher
    ..This study characterizes a pathogenic mechanism utilized by M. avium subsp. hominissuis to bind and invade the host respiratory epithelium, suggesting new potential targets for the development of antivirulence therapy. ..
  6. Yin C, Li M, Hu J, Lang K, Chen Q, Liu J, et al. The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum. BMC Genomics. 2018;19:420 pubmed publisher
    ..These key findings provide new insights into the polyembryony and immune evasion. ..
  7. Schiklenk C, Petrova B, Kschonsak M, Hassler M, Klein C, Gibson T, et al. Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1. J Cell Biol. 2018;217:2383-2401 pubmed publisher
    ..Here, we identify the C2H2 zinc-finger transcription factor Zas1 as a key regulator of mitotic condensation dynamics in a quantitative live-cell microscopy screen of the fission ..
  8. Pal P, Kanaujiya J, Lochab S, Tripathi S, Bhatt M, Singh P, et al. 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562. Proteomics. 2011;11:1517-29 pubmed publisher
    ..Therefore, inclusion of ormeloxifen in the therapy of chronic myeloid leukemia can be of potential utility. ..
  9. Cao S, Strong M, Wang X, Moss W, Concha M, Lin Z, et al. High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project. J Virol. 2015;89:713-29 pubmed publisher
    ..potentially activating integrations in immune regulatory genes, including interleukin-15 (IL-15), IL-6ST, STAT5B, HIVEP1, and IL-9R...

More Information


  1. Saffari H, Kennedy A, Peterson K, Gleich G, Pease L. Non-invasive ultrasound to identify eosinophil granule proteins in eosinophilic esophagitis. Ultrasound Med Biol. 2015;41:884-9 pubmed publisher
    ..Our results suggest the potential of this new class of solid contrast agents to image, diagnose and improve management of eosinophilic esophagitis. ..
  2. Chen C, Zhang Y, Ye P, Ma X, Zheng C, Zhang G. ENO2 knock-out mutants in Arabidopsis modify the regulation of the gene expression response to NaCl stress. Mol Biol Rep. 2018;45:1331-1338 pubmed publisher
  3. Soragni A, Yousefi S, Stoeckle C, Soriaga A, Sawaya M, Kozlowski E, et al. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015;57:1011-1021 pubmed publisher
    ..Our results suggest that MBP-1 aggregation is important for innate immunity and immunopathology mediated by eosinophils and clarify how its polymorphic self-association pathways regulate toxicity intra- and extracellularly. ..
  4. Hsu K, Hsieh R, Wu C, Chi C, Lee Y, Kuo M, et al. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. Mol Biol Cell. 2009;20:5127-37 pubmed publisher
    ..Taken together, these results suggest that MBP-1-suppressed COX-2 expression plays an important role in the inhibition of growth and progression of gastric cancer. ..
  5. Babrak L, Danelishvili L, Rose S, Bermudez L. Microaggregate-associated protein involved in invasion of epithelial cells by Mycobacterium avium subsp. hominissuis. Virulence. 2015;6:694-703 pubmed publisher
    ..In summary, we have unveiled one more step associated with MAH crossing the respiratory mucosa. ..
  6. Sousa D, Porto W, Silva M, da Silva T, Franco O. Influence of Cysteine and Tryptophan Substitution on DNA-Binding Activity on Maize α-Hairpinin Antimicrobial Peptide. Molecules. 2016;21: pubmed publisher
    ..In summary, the data here reported add more information about the multiple mechanisms of action of α-hairpinins. ..
  7. Kader A, Liu X, Dong K, Song S, Pan J, Yang M, et al. Identification of copy number variations in three Chinese horse breeds using 70K single nucleotide polymorphism BeadChip array. Anim Genet. 2016;47:560-9 pubmed publisher
    ..Among these genes, FGF11, SPEM1, PPARG, CIDEB, HIVEP1 and GALR may have potential relevance to breed-specific traits...
  8. Babrak L, Bermudez L. Response of the respiratory mucosal cells to mycobacterium avium subsp. Hominissuis microaggregate. Arch Microbiol. 2018;200:729-742 pubmed publisher
    ..Collectively, this study establishes the different nature of infection by planktonic bacteria and microaggregates. ..
  9. Guiu Jurado E, Unthan M, Böhler N, Kern M, Landgraf K, Dietrich A, et al. Bone morphogenetic protein 2 (BMP2) may contribute to partition of energy storage into visceral and subcutaneous fat depots. Obesity (Silver Spring). 2016;24:2092-100 pubmed publisher
    ..Data suggest that with increasing demand to store excessive energy, AT BMP2 expression increases and may contribute to partitioning of energy storage into visceral and subcutaneous AT depots. ..
  10. Roy S, Schmeier S, Arner E, Alam T, Parihar S, Ozturk M, et al. Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics. Nucleic Acids Res. 2015;43:6969-82 pubmed publisher
    ..Novel TFs, such as Thap6, Maff, (M1) and Hivep1, Nfil3, Prdm1, (M2) among others, were suggested to be involved in the activation processes...
  11. Maranto C, Perconti G, Contino F, Rubino P, Feo S, Giallongo A. Cellular stress induces cap-independent alpha-enolase/MBP-1 translation. FEBS Lett. 2015;589:2110-6 pubmed publisher
    ..Our results contribute to shedding light on the molecular mechanisms underlying MBP-1 expression in non-tumorigenic and cancer cells. ..
  12. Bruzelius M, Iglesias M, Hong M, Sanchez Rivera L, Gyorgy B, Souto J, et al. PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood. 2016;128:e59-e66 pubmed
    ..between VTE occurrence and plasma levels of human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1), von Willebrand factor (VWF), glutathione peroxidase 3 (GPX3), and platelet-derived growth factor ? (PDGFB)...
  13. Tokunaga M, Shiheido H, Tabata N, Sakuma Yonemura Y, Takashima H, Horisawa K, et al. MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. PLoS ONE. 2013;8:e76774 pubmed publisher
    ..This study suggests that the simultaneous targeting of hCAP-G2 and MIP-2A is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours. ..
  14. Ryu S, Na H, Sohn M, Han S, Choi W, In H, et al. Reduced expression of granule proteins during extended survival of eosinophils in splenocyte culture with GM-CSF. Immunol Lett. 2016;173:7-20 pubmed publisher
    ..The relevance of these findings to eosinophilic inflammatory response is discussed. ..
  15. Lu Z, Chen H, Zheng X, Chen M. Expression and clinical significance of high risk human papillomavirus and invasive gene in cervical carcinoma. Asian Pac J Trop Med. 2017;10:195-200 pubmed publisher
    ..The expression has a certain correlation between the level and development of cervical cancer. Through the above indicators, the development of cervical cancer monitoring and treatment to provide important clinical guidance. ..
  16. Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold N, et al. Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise. J Neuroinflammation. 2016;13:289 pubmed
    ..Genes differentially regulated between sexes included TNIP-1, TNIP-3, IL-6, HIVEP1, CXCL3, CCR3, IL-8, and CD69, revealing a bias towards less anti-inflammatory gene regulation in women compared to ..
  17. Ochkur S, Doyle A, Jacobsen E, Lesuer W, Li W, Protheroe C, et al. Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation. J Leukoc Biol. 2017;102:589-599 pubmed publisher
    ..These results highlight the utility of this unique strain of eosinophil-deficient mice as part of in vivo model studies investigating the roles of eosinophils in health and disease settings. ..
  18. Percopo C, Brenner T, Ma M, Kraemer L, Hakeem R, Lee J, et al. SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice. J Leukoc Biol. 2017;101:321-328 pubmed publisher
    ..These cytokines may facilitate eosinophil-mediated immunomodulatory responses in the allergen-challenged lung as well as in other distinct microenvironments. ..
  19. McClay J, Adkins D, Aberg K, Stroup S, Perkins D, Vladimirov V, et al. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry. 2011;16:76-85 pubmed publisher
    ..This study demonstrates the potential of genome-wide association studies to discover novel genes that mediate the effects of antipsychotics, which could eventually help to tailor drug treatment to schizophrenic patients. ..
  20. Omichinski J, Clore G, Robien M, Sakaguchi K, Appella E, Gronenborn A. High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1. Biochemistry. 1992;31:3907-17 pubmed
  21. Maekawa T, Sakura H, Sudo T, Ishii S. Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. J Biol Chem. 1989;264:14591-3 pubmed
    ..This represents the first demonstration of the structural feature of the protein that binds to the HIV-1 enhancer. ..
  22. Omichinski J, Clore G, Appella E, Sakaguchi K, Gronenborn A. High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry. 1990;29:9324-34 pubmed
  23. Zuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, et al. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:437-44 pubmed publisher
    ..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence. ..
  24. Yu B, Mitchell G, Richter A. Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1. Exp Cell Res. 2009;315:3086-98 pubmed publisher
    ..Subcellular localization is unaffected by the mutation. Yeast two-hybrid screening identified Cirip (Cirhin interaction protein) and found that interaction between Cirip and R565W-Cirhin was weakened...
  25. Fan C, Maniatis T. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev. 1990;4:29-42 pubmed
    ..Although the function of PRDII-BF1 is not known, the level of its mRNA is inducible by serum and virus, albeit with different kinetics. ..
  26. Nakamura T, Donovan D, Hamada K, Sax C, Norman B, Flanagan J, et al. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Mol Cell Biol. 1990;10:3700-8 pubmed
    ..It encoded a protein, tentatively called alpha A-CRYBP1, containing at least two zinc fingers...
  27. Otsuka M, Fujita M, Aoki T, Ishii S, Sugiura Y, Yamamoto T, et al. Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B. J Med Chem. 1995;38:3264-70 pubmed
    ..Thus, it became possible to inhibit either one of the two kappa B site-binding proteins without inhibiting the other.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  28. Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 2006;34:1735-44 pubmed
    ..The HMG domain thus not only possesses DNA-binding and DNA-bending but also protein-interacting ability which may be equally important for the architectural function of Sox proteins on their target gene promoters. ..
  29. Seeler J, Muchardt C, Suessle A, Gaynor R. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol. 1994;68:1002-9 pubmed
    ..These results are consistent with a role for PRDII-BF1 in activating HIV-1 gene expression. ..
  30. Baldwin A, LeClair K, Singh H, Sharp P. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. Mol Cell Biol. 1990;10:1406-14 pubmed
    ..Interestingly, expression of MBP-1 mRNA was inducible by mitogen and phorbol ester treatment of Jurkat T cells and by serum treatment of confluent serum-deprived human fibroblasts. ..
  31. Muchardt C, Seeler J, Nirula A, Shurland D, Gaynor R. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. J Virol. 1992;66:244-50 pubmed
    ..These results indicate that multiple enhancer binding proteins may potentially regulate HIV in both a positive and negative manner. ..
  32. Morange P, Bezemer I, Saut N, Bare L, Burgos G, Brocheton J, et al. A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. Am J Hum Genet. 2010;86:592-5 pubmed publisher
    ..Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT...
  33. Hsu K, Wang A, Ping Y, Huang K, Huang T, Lee H, et al. Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis. Carcinogenesis. 2014;35:208-17 pubmed publisher
    ..Taken together, these results suggest that miR-363 plays an important role in the increment of gastric carcinogenesis via targeting MBP-1. ..
  34. Gaynor R, Muchardt C, Diep A, Mohandas T, Sparkes R, Lusis A. Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24. Genomics. 1991;9:758-61 pubmed
    ..As part of an effort to examine the chromosomal organization of cellular genes encoding transcription factors, we report the chromosomal mapping of the gene encoding this zinc finger protein (ZNF40) to chromosome 6p22.3-24.