histone H3

Summary

Gene Symbol: histone H3
Description: H3 histone family member 3A
Alias: H3.3A, H3F3, histone H3.3, H3 histone, family 3A
Species: human
Products:     histone H3

Top Publications

  1. Chow C, Georgiou A, Szutorisz H, Maia e Silva A, Pombo A, Barahona I, et al. Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division. EMBO Rep. 2005;6:354-60 pubmed
    Variant histone H3.3 is incorporated into nucleosomes by a mechanism that does not require DNA replication and has also been implicated as a potential mediator of epigenetic memory of active transcriptional states...
  2. Hake S, Garcia B, Duncan E, Kauer M, Dellaire G, Shabanowitz J, et al. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem. 2006;281:559-68 pubmed
    ..1 and H3.2 in mammalian cells should not be treated as equivalent proteins. ..
  3. Goldberg A, Banaszynski L, Noh K, Lewis P, Elsaesser S, Stadler S, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678-91 pubmed publisher
    The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3...
  4. Schwartzentruber J, Korshunov A, Liu X, Jones D, Pfaff E, Jacob K, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482:226-31 pubmed publisher
    ..This is, to our knowledge, the first report to highlight recurrent mutations in a regulatory histone in humans, and our data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis. ..
  5. Tagami H, Ray Gallet D, Almouzni G, Nakatani Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell. 2004;116:51-61 pubmed
    Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway...
  6. Li H, Ilin S, Wang W, Duncan E, Wysocka J, Allis C, et al. Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature. 2006;442:91-5 pubmed
    ..For example, histone H3 trimethylated at lysine 4 (H3K4me3) is associated with transcription start sites of active genes, but the ..
  7. Garcia B, Hake S, Diaz R, Kauer M, Morris S, Recht J, et al. Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem. 2007;282:7641-55 pubmed publisher
    ..Using a combination of mass spectrometric and immunobiochemical approaches, we show that the PTM profile of histone H3 differs significantly among the various model organisms examined...
  8. Ray Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, et al. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell. 2011;44:928-41 pubmed publisher
    ..3, and HIRA association with Pol II ensures local H3.3 enrichment at specific sites. We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity. ..
  9. Gielen G, Gessi M, Hammes J, Kramm C, Waha A, Pietsch T. H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas. Am J Clin Pathol. 2013;139:345-9 pubmed publisher
    ..Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these ..

More Information

Publications132 found, 100 shown here

  1. Chan K, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013;27:985-90 pubmed publisher
    ..have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases...
  2. Behjati S, Tarpey P, Presneau N, Scheipl S, Pillay N, Van Loo P, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013;45:1479-82 pubmed publisher
    ..Here, however, we report exquisite tumor type specificity for different histone H3.3 driver alterations. In 73 of 77 cases of chondroblastoma (95%), we found p...
  3. Loyola A, Bonaldi T, Roche D, Imhof A, Almouzni G. PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell. 2006;24:309-16 pubmed
    ..Although the set of initial modifications present on H3.1 is permissive for further modifications, in H3.3 a subset cannot be K9me3. Thus, initial modifications impact final PTMs within chromatin. ..
  4. Jin C, Zang C, Wei G, Cui K, Peng W, Zhao K, et al. H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet. 2009;41:941-5 pubmed publisher
    ..Other combinations of variants have different distributions, consistent with distinct roles for histone variants in the modulation of gene expression. ..
  5. Tachiwana H, Osakabe A, Shiga T, Miya Y, Kimura H, Kagawa W, et al. Structures of human nucleosomes containing major histone H3 variants. Acta Crystallogr D Biol Crystallogr. 2011;67:578-83 pubmed publisher
    ..In humans, eight histone H3 variants, H3.1, H3.2, H3.3, H3T, H3.5, H3.X, H3.Y and CENP-A, have been reported to date...
  6. Delbarre E, Ivanauskiene K, Küntziger T, Collas P. DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. Genome Res. 2013;23:440-51 pubmed publisher
    ..3-H4) dimer rather than as a tetramer. Our data support a model of DAXX-mediated recruitment of (H3.3-H4) dimers to PML bodies, which may function as triage centers for H3.3 deposition into chromatin by distinct chaperones. ..
  7. Venneti S, Garimella M, Sullivan L, Martinez D, Huse J, Heguy A, et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol. 2013;23:558-64 pubmed publisher
    ..Sixteen genes encode histone H3, each variant differing in only a few amino acids...
  8. Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010;24:1253-65 pubmed publisher
    The histone variant H3.3 marks active chromatin by replacing the conventional histone H3.1. In this study, we investigate the detailed mechanism of H3.3 replication-independent deposition...
  9. Lewis P, Elsaesser S, Noh K, Stadler S, Allis C. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A. 2010;107:14075-80 pubmed publisher
    ..These data demonstrate that Daxx functions as an H3.3-specific chaperone and facilitates the deposition of H3.3 at heterochromatin loci in the context of the ATRX-Daxx complex. ..
  10. Elsässer S, Huang H, Lewis P, Chin J, Allis C, Patel D. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature. 2012;491:560-5 pubmed publisher
    ..3. Here we report the crystal structures of the DAXX histone-binding domain with a histone H3.3-H4 dimer, including mutants within DAXX and H3...
  11. Sturm D, Witt H, Hovestadt V, Khuong Quang D, Jones D, Konermann C, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012;22:425-37 pubmed publisher
    ..We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of pediatric GBM...
  12. Gessi M, Gielen G, Hammes J, Dörner E, Mühlen A, Waha A, et al. H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications?. J Neurooncol. 2013;112:67-72 pubmed publisher
    ..recently have been exon sequenced with evidence that approximately 30 % of cases harbour mutations of the histone H3.3 gene...
  13. Lewis P, Müller M, Koletsky M, Cordero F, Lin S, Banaszynski L, et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science. 2013;340:857-61 pubmed publisher
    ..pediatric gliomas has identified missense mutations Lys27Met (K27M) and Gly34Arg/Val (G34R/V) in genes encoding histone H3.3 (H3F3A) and H3.1 (HIST3H1B)...
  14. Lacoste N, Woolfe A, Tachiwana H, Garea A, Barth T, Cantaloube S, et al. Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX. Mol Cell. 2014;53:631-44 pubmed publisher
    ..Our findings illustrate how changes in histone variant levels can disrupt chromatin dynamics and suggests a possible mechanism for cell resistance to anticancer treatments. ..
  15. Khuong Quang D, Buczkowicz P, Rakopoulos P, Liu X, Fontebasso A, Bouffet E, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012;124:439-47 pubmed publisher
    ..Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3...
  16. Liu C, Xiong C, Wang M, Yu Z, Yang N, Chen P, et al. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat Struct Mol Biol. 2012;19:1287-92 pubmed publisher
    Mammalian histone H3.3 is a variant of the canonical H3.1 essential for genome reprogramming in fertilized eggs and maintenance of chromatin structure in neuronal cells. An H3...
  17. Bender S, Tang Y, Lindroth A, Hovestadt V, Jones D, Kool M, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell. 2013;24:660-72 pubmed publisher
  18. Aihara K, Mukasa A, Gotoh K, Saito K, Nagae G, Tsuji S, et al. H3F3A K27M mutations in thalamic gliomas from young adult patients. Neuro Oncol. 2014;16:140-6 pubmed publisher
    Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma...
  19. Zanello M, Pages M, Tauziède Espariat A, Saffroy R, Puget S, Lacroix L, et al. Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma. J Neuropathol Exp Neurol. 2016;75:971-980 pubmed
    ..K27M H3F3A mutation (17%). AGGs are malignant neoplasms requiring aggressive oncological treatment. In the perspective of targeted therapies, AGGs should be screened for BRAF V600E, hTERT, ATRX, and mutations of histone genes. ..
  20. Bressan R, Dewari P, Kalantzaki M, Gangoso E, Matjusaitis M, Garcia Diaz C, et al. Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells. Development. 2017;144:635-648 pubmed publisher
    ..These resources and optimised methods enable facile and scalable genome editing in mammalian NSCs, providing significant new opportunities for functional genetic analysis. ..
  21. Karremann M, Gielen G, Hoffmann M, Wiese M, Colditz N, Warmuth Metz M, et al. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol. 2017;: pubmed publisher
    ..They are defined by K27M mutations in H3F3A or HIST1H3B/C, encoding for histone 3 variants H3.3 and H3.1, respectively, which are considered hallmark events driving gliomagenesis...
  22. Nakata S, Nobusawa S, Yamazaki T, Osawa T, Horiguchi K, Hashiba Y, et al. Histone H3 K27M mutations in adult cerebellar high-grade gliomas. Brain Tumor Pathol. 2017;34:113-119 pubmed publisher
    ..In the present study, we assessed the prevalence of histone H3 K27M mutations in ten adult cerebellar HGG, identifying two H3F3A-mutant cases...
  23. Miao F, Li S, Chavez V, Lanting L, Natarajan R. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. Mol Endocrinol. 2006;20:1562-73 pubmed
    ..with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17)...
  24. Kohzuki H, Matsuda M, Miki S, Shibuya M, Ishikawa E, Matsumura A. Diffusely Infiltrating Cerebellar Anaplastic Astrocytoma Effectively Controlled with Bevacizumab: Case Report and Literature Review. World Neurosurg. 2018;115:181-185 pubmed publisher
    ..Bevacizumab treatment may be a salvage treatment option for patients with diffusely infiltrating cerebellar gliomas that exhibits rapid progression during standard treatment. ..
  25. Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy F, Walsh M. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J Biol Chem. 2004;279:54348-57 pubmed
    ..This methyltransferase activity is directed specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with co-activator-associated arginine methyltransferase 1 (CARM1)..
  26. Okino C, Ibelli A, Brentano L, Zanella R, Groke Marques M. Evaluation of candidate reference genes for investigation of the uterine tissue and corpus luteum of pigs on day 6 after artificial insemination. Anim Reprod Sci. 2018;198:202-209 pubmed publisher
    ..of ubiquitin (UBB), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), DNA topoisomerase 2-beta (TOP2B), histone H3 (H3F3A) and hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) abundances of mRNA were evaluated using the ..
  27. Anderson J, Muraleedharan R, Oatman N, Klotter A, Sengupta S, Waclaw R, et al. The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro Oncol. 2017;19:1068-1078 pubmed publisher
    ..However, the mechanisms regulating an altered differentiation program in DIPG are unknown...
  28. Cordero F, Huang Z, Grenier C, He X, Hu G, McLendon R, et al. Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG. Mol Cancer Res. 2017;15:1243-1254 pubmed publisher
    ..brainstem tumor genetically distinguished from adult GBM by the high prevalence of the K27M mutation in the histone H3 variant H3.3 (H3F3A)...
  29. Corpet A, Olbrich T, Gwerder M, Fink D, Stucki M. Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization. Cell Cycle. 2014;13:249-67 pubmed publisher
    ..Here, we investigated the specific targeting and dynamics of histone H3 variants in human primary senescent cells. We show that newly synthesized epitope-tagged H3...
  30. Puech C, Dedieu L, Chantal I, Rodrigues V. Design and evaluation of a unique SYBR Green real-time RT-PCR assay for quantification of five major cytokines in cattle, sheep and goats. BMC Vet Res. 2015;11:65 pubmed publisher
    ..This accurate and easily reproducible tool can be used to investigate ruminant immune responses and is widely accessible to the veterinary research community. ..
  31. Kim J, Cho E, Kim S, Youn H. CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat Struct Mol Biol. 2005;12:423-8 pubmed publisher
    ..coactivators bind to acetylated histones through their bromodomains and catalyze the acetylation of histone H3 and H4 tails for transcriptional activation...
  32. Viana Pereira M, Almeida G, Stavale J, Malheiro S, Clara C, Lobo P, et al. Study of hTERT and Histone 3 Mutations in Medulloblastoma. Pathobiology. 2017;84:108-113 pubmed publisher
    ..Additionally, there are alternative telomere maintenance mechanisms, associated with histone H3 mutations, responsible for disrupting the histone code and affecting the regulation of transcription...
  33. Nightingale K, Gendreizig S, White D, Bradbury C, Hollfelder F, Turner B. Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation. J Biol Chem. 2007;282:4408-16 pubmed
    ..modification-specific antibodies to demonstrate that two histone modifications involved in gene activation, histone H3 acetylation and H3 lysine 4 methylation, are functionally linked...
  34. Trabelsi S, Chabchoub I, Ksira I, Karmeni N, Mama N, Kanoun S, et al. Molecular Diagnostic and Prognostic Subtyping of Gliomas in Tunisian Population. Mol Neurobiol. 2017;54:2381-2394 pubmed publisher
    ..Furthermore, by exhibiting a remarkable methylation profile, it emphasised the oncogenic power of G34R mutation connecting gliomagenesis and chromatin regulation. ..
  35. Zhang Y, Pan C, Wang J, Cao J, Liu Y, Wang Y, et al. Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget. 2017;8:82571-82582 pubmed publisher
  36. Khanna G, Pathak P, Suri V, Sharma M, Chaturvedi S, Ahuja A, et al. Immunohistochemical and molecular genetic study on epithelioid glioblastoma: Series of seven cases with review of literature. Pathol Res Pract. 2018;214:679-685 pubmed publisher
    ..H3F3A mutations and PTEN deletions were seen in none. Although e-gbms are rare, epithelioid morphology of a CNS tumor in a young adult or children with areas of necrosis needs thorough histomorphological and genetic workup. ..
  37. Ulucan O, Keskin O, Erman B, Gursoy A. A comparative molecular dynamics study of methylation state specificity of JMJD2A. PLoS ONE. 2011;6:e24664 pubmed publisher
    ..Our study provides new insights into how JMJD2A discriminates between its substrates from both a structural and dynamical point of view. ..
  38. Venneti S, Santi M, Felicella M, Yarilin D, Phillips J, Sullivan L, et al. A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas. Acta Neuropathol. 2014;128:743-53 pubmed publisher
    ..GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M mutations lead to global reduction in H3K27me3...
  39. Gomes C, Diniz M, Amaral F, Antonini Guimarães B, Gomez R. The highly prevalent H3F3A mutation in giant cell tumours of bone is not shared by sporadic central giant cell lesion of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:583-5 pubmed publisher
    ..Gly34 Trp or p.Gly34 Leu in H3F3A, one of two genes for histone H3.3 located on chromosome 1...
  40. Hong B, Banan R, Christians A, Nakamura M, Lalk M, Lehmann U, et al. Cerebellar glioblastoma: a clinical series with contemporary molecular analysis. Acta Neurochir (Wien). 2018;160:2237-2248 pubmed publisher
    ..Mutation of BRAF V600E may have a stronger biological significance than H3F3A K27M alterations. In a subset of patients, GBM may arise primarily as a distinct entity in the cerebellum. ..
  41. Elsaesser S, Allis C. HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes. Cold Spring Harb Symp Quant Biol. 2010;75:27-34 pubmed publisher
    b>Histone H3.3 is a universal replacement histone in metazoans that has been implicated in diverse processes ranging from gene activation to heterochromatin silencing. Here, we show that, before deposition, H3...
  42. Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A. Glioblastoma: pathology, molecular mechanisms and markers. Acta Neuropathol. 2015;129:829-48 pubmed publisher
  43. Capper D, Reifenberger G. [Classification of gliomas. Current progress and perspectives]. Nervenarzt. 2015;86:672, 674-6, 678-80, passim pubmed publisher
    ..in the isocitrate dehydrogenase 1 (IDH1), IDH2, alpha thalassemia/mental retardation syndrome X-linked (ATRX), histone H3.3 (H3F3A) and v-raf murine sarcoma viral oncogene homolog B (BRAF) genes as well as the demonstration of ..
  44. Zhang K, Wang H, Rajput S, Folger J, Smith G. Characterization of H3.3 and HIRA expression and function in bovine early embryos. Mol Reprod Dev. 2017;: pubmed publisher
    ..Additionally, we noted that Histone H3 lysine 36 dimethylation and linker Histone H1 abundance is reduced in H3...
  45. Zhong S, Zhang Y, Jansen C, Goto H, Inagaki M, Dong Z. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem. 2001;276:12932-7 pubmed
    b>Histone H3 phosphorylation is related closely to chromatin remodeling and chromosome condensation. H3 phosphorylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines...
  46. Nguyen A, Colin C, Nanni Metellus I, Padovani L, Maurage C, Varlet P, et al. Evidence for BRAF V600E and H3F3A K27M double mutations in paediatric glial and glioneuronal tumours. Neuropathol Appl Neurobiol. 2015;41:403-8 pubmed publisher
  47. Castel D, Philippe C, Calmon R, LE Dret L, Truffaux N, Boddaert N, et al. Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 2015;130:815-27 pubmed publisher
    ..b>Histone H3 genes mutations were assessed by immunochemistry and direct sequencing, whilst global gene expression profiling ..
  48. Yoshimoto K, Hatae R, Sangatsuda Y, Suzuki S, Hata N, Akagi Y, et al. Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution. Brain Tumor Pathol. 2017;34:103-112 pubmed publisher
    ..These results indicate that G34R-mutant tumors are likely to show extensive infiltration and alterations in global histone trimethylation might also play an important role in G34R mutant tumors. ..
  49. Leghmari K, Bennasser Y, Bahraoui E. HIV-1 Tat protein induces IL-10 production in monocytes by classical and alternative NF-kappaB pathways. Eur J Cell Biol. 2008;87:947-62 pubmed publisher
    ..assay experiments, after Tat treatment, revealed IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) in this region, presumably leading to chromatin remodeling...
  50. Han J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell. 2013;155:817-29 pubmed publisher
    ..Here, we show that yeast Rtt101(Mms1) E3 ubiquitin ligase preferentially binds and ubiquitylates new histone H3 acetylated at lysine 56...
  51. Varier R, Outchkourov N, de Graaf P, van Schaik F, Ensing H, Wang F, et al. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. EMBO J. 2010;29:3967-78 pubmed publisher
    ..High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor...
  52. Palsgrove D, Brosnan Cashman J, Giannini C, Raghunathan A, Jentoft M, Bettegowda C, et al. Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association. Mod Pathol. 2018;31:1787-1800 pubmed publisher
    ..These findings suggest that subependymal giant cell astrocytoma-like astrocytoma represents a biologically distinct group that merits further investigation. ..
  53. Ebrahimi A, Skardelly M, Bonzheim I, Ott I, Mühleisen H, Eckert F, et al. ATRX immunostaining predicts IDH and H3F3A status in gliomas. Acta Neuropathol Commun. 2016;4:60 pubmed publisher
    ..Such classification is of great importance for further clinical decision making especially concerning the therapeutic options available for diffuse gliomas. ..
  54. Tsukamoto S, Righi A, Vanel D, Honoki K, Donati D, Errani C. Development of high-grade osteosarcoma in a patient with recurrent giant cell tumor of the ischium while receiving treatment with denosumab. Jpn J Clin Oncol. 2017;47:1090-1096 pubmed publisher
    ..The mechanism of sarcomatous transformation of GCTB during denosumab therapy is unclear. These findings suggest that the scientific community should be aware of the possible malignant transformation of GCTB during denosumab treatment...
  55. Winkler D, Muthurajan U, Hieb A, Luger K. Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem. 2011;286:41883-92 pubmed publisher
    ..Together, the data reveal that specific FACT subunits synchronize interactions with various target sites on individual nucleosomes to generate a high affinity binding event and promote reorganization. ..
  56. Li X, Yang H, Huang S, Qiu Y. Histone deacetylase 1 and p300 can directly associate with chromatin and compete for binding in a mutually exclusive manner. PLoS ONE. 2014;9:e94523 pubmed publisher
    ..HDAC1 and p300 directly bind to the overlapping regions of the histone H3 tail and compete for histone binding...
  57. Appin C, Brat D. Biomarker-driven diagnosis of diffuse gliomas. Mol Aspects Med. 2015;45:87-96 pubmed publisher
    ..These gliomas often harbor mutations or activating gene rearrangements in BRAF. ..
  58. Kajitani T, Kanamori M, Saito R, Watanabe Y, Suzuki H, Watanabe M, et al. Three case reports of radiation-induced glioblastoma after complete remission of acute lymphoblastic leukemia. Brain Tumor Pathol. 2018;35:114-122 pubmed publisher
    ..Radiation-induced glioblastoma occurring after the treatment for ALL had unique clinical, radiological, histological, and molecular characteristics in our three cases. ..
  59. Preuss U, Landsberg G, Scheidtmann K. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. Nucleic Acids Res. 2003;31:878-85 pubmed
    ..Interestingly, Dlk/ZIP kinase phosphorylated histone H3 at a novel site, Thr11, rather than Ser10, which is characteristic of mitotic chromosomes...
  60. Wong L, McGhie J, Sim M, Anderson M, Ahn S, Hannan R, et al. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res. 2010;20:351-60 pubmed publisher
    ..We show by coimmunoprecipitation that this localization is dependent on the association of ATRX with histone H3.3, and that mutating the K4 residue of H3.3 significantly diminishes ATRX and H3.3 interaction...
  61. Wang F, Chen F, Gao W, Wang H, Zhao N, Xu M, et al. Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF. Clin Rheumatol. 2016;35:2185-94 pubmed publisher
    ..Interestingly, citrullinated histone H3.3 (H3F3A) was found in OA controls, but not in RA groups...
  62. Ryall S, Krishnatry R, Arnoldo A, Buczkowicz P, Mistry M, Siddaway R, et al. Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma. Acta Neuropathol Commun. 2016;4:93 pubmed publisher
    ..Our data strongly supports the inclusion of targeted genetic testing in childhood thalamic tumours to most accurately stratify patients into appropriate risk groups. ..
  63. Martinez Ricarte F, Mayor R, Martínez Sáez E, Rubio Perez C, Pineda E, Cordero E, et al. Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid. Clin Cancer Res. 2018;24:2812-2819 pubmed publisher
    ..i>Clin Cancer Res; 24(12); 2812-9. ©2018 AACR. ..
  64. Wells D, Hoffman D, Kedes L. Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. Nucleic Acids Res. 1987;15:2871-89 pubmed
    ..We also present the sequence of three related processed human H3.3 pseudogenes and provide evidence demonstrating that most of the 20 to 30 copies of the H3.3 gene within the human genome are in fact processed pseudogenes. ..
  65. Pathak P, Jha P, Purkait S, Sharma V, Suri V, Sharma M, et al. Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM. J Neurooncol. 2015;121:489-97 pubmed publisher
    ..Hence therapies for patients with particular combinations of histone modifications present opportunity to design innovative patient-tailored treatment protocols. ..
  66. Sarungbam J, Agaram N, Hwang S, Lu C, Wang L, Healey J, et al. Symplastic/pseudoanaplastic giant cell tumor of the bone. Skeletal Radiol. 2016;45:929-35 pubmed publisher
    ..Recently, somatic driver mutations of histone H3.3 exclusively in H3F3A have been described in GCTB...
  67. Hewer E, Prebil N, Berezowska S, Gutt Will M, Schucht P, Dettmer M, et al. Diagnostic implications of TERT promoter mutation status in diffuse gliomas in a routine clinical setting. Virchows Arch. 2017;471:641-649 pubmed publisher
  68. Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, et al. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem. 1999;274:25543-9 pubmed
    b>Histone H3 (H3) phosphorylation at Ser(10) occurs during mitosis in eukaryotes and was recently shown to play an important role in chromosome condensation in Tetrahymena...
  69. Herrlinger U, Jones D, Glas M, Hattingen E, Gramatzki D, Stuplich M, et al. Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathol. 2016;131:309-319 pubmed publisher
    ..These data support the removal of GC as a distinct glioma entity in the upcoming revision of the WHO classification. ..
  70. Lee J, Solomon D, Tihan T. The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children. J Neurooncol. 2017;132:1-11 pubmed publisher
    ..Mutations including K27M and G34R/V that affect critical amino acids within the N-terminal tail of the histone H3 variants, H3.3 and H3...
  71. Gates L, Shi J, Rohira A, Feng Q, Zhu B, Bedford M, et al. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation. J Biol Chem. 2017;292:14456-14472 pubmed publisher
    ..Two histone marks on histone H3, lysine 4 trimethylation (H3K4me3) and lysine 9 acetylation (H3K9ac), co-localize on active gene promoters and ..
  72. Johnson A, Severson E, Gay L, Vergilio J, Elvin J, Suh J, et al. Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. Oncologist. 2017;22:1478-1490 pubmed publisher
    ..This provides support for TMB as a potential biomarker to identify patients who may preferentially benefit from immune checkpoint inhibitors. ..
  73. Kato I, Furuya M, Matsuo K, Kawabata Y, Tanaka R, Ohashi K. Giant Cell Tumours of Bone Treated with Denosumab: Histologic, Immunohistochemical, and H3F3A Mutation Analyses. Histopathology. 2017;: pubmed publisher
    ..The aim of this study was to investigate the histopathological features and H3F3A mutation status of GCTBs treated with denosumab...
  74. Gamberi G, Morandi L, Benini S, Resca A, Cocchi S, Magagnoli G, et al. Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). Pathol Res Pract. 2018;214:89-94 pubmed publisher
    ..We demonstrated that ASLNAqPCR is a quick, sensitive and reliable method to identify mutations of the H3F3A gene, in giant cell tumor of bone, to support diagnosis in morphologically ambiguous cases. ..
  75. Nomura M, Mukasa A, Nagae G, Yamamoto S, Tatsuno K, Ueda H, et al. Distinct molecular profile of diffuse cerebellar gliomas. Acta Neuropathol. 2017;134:941-956 pubmed publisher
    ..These findings may suggest potential tailored targeted therapy for gliomas according to their brain region, in addition to providing molecular clues to identify the region-related cellular origin of DCGs. ..
  76. Huyen Y, Zgheib O, DiTullio R, Gorgoulis V, Zacharatos P, Petty T, et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature. 2004;432:406-11 pubmed
    ..In vitro, the 53BP1 tandem tudor domain bound histone H3 methylated on Lys 79 using residues that form the walls of the pocket; these residues were also required for ..
  77. Daury L, Chailleux C, Bonvallet J, Trouche D. Histone H3.3 deposition at E2F-regulated genes is linked to transcription. EMBO Rep. 2006;7:66-71 pubmed
    ..3 occupancy correlated with the presence of transcription-competent RNA polymerase II. Taken together, our results support the hypothesis that H3.3 is incorporated after disruption of nucleosomes mediated by transcription elongation. ..
  78. Otani J, Nankumo T, Arita K, Inamoto S, Ariyoshi M, Shirakawa M. Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep. 2009;10:1235-41 pubmed publisher
    ..ATRX-DNMT3-DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the amino-terminal tail of histone H3. Combined with the results of biochemical analysis, the complex structure indicates that DNMT3A recognizes the ..
  79. Je E, Yoo N, Kim Y, Kim M, Lee S. Somatic mutation of H3F3A, a chromatin remodeling gene, is rare in acute leukemias and non-Hodgkin lymphoma. Eur J Haematol. 2013;90:169-70 pubmed publisher
  80. Reyes Botero G, Giry M, Mokhtari K, Labussiere M, Idbaih A, Delattre J, et al. Molecular analysis of diffuse intrinsic brainstem gliomas in adults. J Neurooncol. 2014;116:405-11 pubmed publisher
    ..R132H, alpha internexin, p53, and Ki67 expression, and, in a subset with sufficient DNA amount, for IDH1 and histone H3 mutational status, genomic profiling and MGMT promoter methylation status...
  81. Zegerman P, Canas B, Pappin D, Kouzarides T. Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem. 2002;277:11621-4 pubmed
    ..proteins, such as GCN5, bind acetyl lysines and the chromodomain protein, HP1, binds methyl lysine 9 of histone H3. Here we show that the previously characterized transcriptional repressor complex NuRD (nucleosome remodeling ..
  82. Xu L, Zhao Z, Dong A, Soubigou Taconnat L, Renou J, Steinmetz A, et al. Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana. Mol Cell Biol. 2008;28:1348-60 pubmed
    ..Together our results reveal that the deposition of H3K36 methylation is finely regulated, possibly to cope with the complex regulation of growth and development in higher eukaryotes. ..
  83. Attieh Y, Geng Q, DiNardo C, Zheng H, Jia Y, Fang Z, et al. Low frequency of H3.3 mutations and upregulated DAXX expression in MDS. Blood. 2013;121:4009-11 pubmed publisher
  84. Hoffman L, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, et al. Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol Commun. 2016;4:1 pubmed publisher
  85. Yadav R, Jablonowski C, Fernandez A, Lowe B, Henry R, Finkelstein D, et al. Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe. elife. 2017;6: pubmed publisher
    ..somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler...
  86. Wells D, Kedes L. Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. Proc Natl Acad Sci U S A. 1985;82:2834-8 pubmed
    ..Hybridization of subsegments of the cDNA to human genomic DNA reveals a complex multigene family. The differences in the structures of basal and cell-cycle histone genes suggest a model to explain the differences in their expression. ..
  87. Solomon D, Wood M, Tihan T, Bollen A, Gupta N, Phillips J, et al. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2016;26:569-80 pubmed publisher
    Somatic mutations of the H3F3A and HIST1H3B genes encoding the histone H3 variants, H3.3 and H3.1, were recently identified in high-grade gliomas arising in the thalamus, pons and spinal cord of children and young adults...
  88. Li Z, Sun Q, Shi Y. Somatic structural variations in pediatric brain tumors- an update. Minerva Pediatr. 2017;: pubmed publisher
    ..Although, only few have been described in pHGG. Structural variants (SV) frequently result in chimeric proteins targetable by novel therapeutic approaches, an outcome desperately needed in pHGG. ..
  89. Nohr E, Lee L, Cates J, Perizzolo M, Itani D. Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors. Hum Pathol. 2017;68:119-127 pubmed publisher
  90. Yamamoto H, Iwasaki T, Yamada Y, Matsumoto Y, Otsuka H, Yoshimoto M, et al. Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone. Hum Pathol. 2018;73:41-50 pubmed publisher
    ..Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3.3 G34W, G34R and G34V mutant proteins for GCTB and other histologically similar bone and joint lesions. H3...
  91. Bauer U, Daujat S, Nielsen S, Nightingale K, Kouzarides T. Methylation at arginine 17 of histone H3 is linked to gene activation. EMBO Rep. 2002;3:39-44 pubmed
    The nuclear hormone receptor co-activator CARM1 has the potential to methylate histone H3 at arginine residues in vitro. The methyltransferase activity of CARM1 is necessary for its co-activator functions in transient transfection assays...
  92. Kouskouti A, Talianidis I. Histone modifications defining active genes persist after transcriptional and mitotic inactivation. EMBO J. 2005;24:347-57 pubmed
    ..The findings suggest that histone modifications may function as molecular memory bookmarks for previously active locations of the genome, thus contributing to the maintenance of active chromatin states through cell division. ..