histidine decarboxylase


Gene Symbol: histidine decarboxylase
Description: histidine decarboxylase
Alias: histidine decarboxylase
Species: human
Products:     histidine decarboxylase

Top Publications

  1. Zhang F, Xiong D, Wang W, Shen H, Xiao P, Yang F, et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem Biophys Res Commun. 2006;348:1378-82 pubmed
    b>Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Studies have shown that histamine is likely to be involved in the regulation of reproduction system...
  2. Gervasini G, Agúndez J, García Menaya J, Martinez C, Cordobés C, Ayuso P, et al. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. Allergy. 2010;65:1576-84 pubmed publisher
    ..The role of polymorphisms in the histidine decarboxylase gene remains unexplored...
  3. Vasiadi M, Newman J, Theoharides T. Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome. J Neuroinflammation. 2014;11:168 pubmed publisher
    ..b>Histidine decarboxylase (HDC) and NT expression were also increased, but only in the skin, over the same period...
  4. Provensi G, Costa A, Passani M, Blandina P. Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse. Neuropharmacology. 2016;109:139-147 pubmed publisher
    ..However, these compounds were ineffective in either genetically (histidine decarboxylase knock-out, HDC-KO) or pharmacologically, by means of intracerebroventricular (i.c.v...
  5. Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C. Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. Brain Behav Immun. 2016;57:326-337 pubmed publisher
    ..We used immunohistochemistry to examine the effects of HA deficiency in histidine decarboxylase (Hdc) knockout mice and of HA receptor stimulation in wild-type animals...
  6. Murakami M, Yoshikawa T, Nakamura T, Ohba T, Matsuzaki Y, Sawamura D, et al. Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun. 2015;458:584-589 pubmed publisher
    ..l-Histidine decarboxylase (HDC) expression in the superior cervical ganglion of H1R-null mice was higher than that in WT controls, ..
  7. Munari L, Provensi G, Passani M, Galeotti N, Cassano T, Benetti F, et al. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Int J Neuropsychopharmacol. 2015;18:pyv045 pubmed publisher
    ..or paroxetine) are abolished in mice unable to synthesize histamine due to either targeted disruption of histidine decarboxylase gene (HDC(-/-)) or injection of alpha-fluoromethylhistidine, a suicide inhibitor of this enzyme...
  8. He G, Hu J, Li T, Ma X, Meng J, Jia M, et al. Arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemia. Mol Med. 2012;18:1-9 pubmed publisher
    ..Mast cell-deficient mice (MCDM) and histidine decarboxylase knockout (HDC(-/-)) mice were used to exclude the potential involvement of mast cells...
  9. Zhang J, Zhu X, Xu R, Gao Q, Wang D, Zhang Y. Isolation and identification of histamine-producing Enterobacteriaceae from Qu fermentation starter for Chinese rice wine brewing. Int J Food Microbiol. 2018;281:1-9 pubmed publisher
    ..Surprisingly, the histidine decarboxylase gene (hdc) was present in only 2 out of 26 isolates...

More Information

Publications126 found, 100 shown here

  1. Shaik Dasthagirisaheb Y, Conti P. Letter to Editor: Chemokine Network Involved in Inflammatory Skin Diseases. Ann Clin Lab Sci. 2015;45:452-7 pubmed
    ..provoke the recruitment of inflammatory cells, release of cytokines, and activation of transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, which may cause fatal ..
  2. Fujita A, Bonnavion P, Wilson M, Mickelsen L, Bloit J, de Lecea L, et al. Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability. J Neurosci. 2017;37:9574-9592 pubmed publisher
    ..For this purpose, we first validated a transgenic mouse line expressing cre recombinase in histidine decarboxylase-expressing neurons (Hdc-Cre) followed by a systematic census of the membrane properties of both HA ..
  3. Flores Balter G, Cordova Jadue H, Chiti Morales A, Lespay C, Espina Marchant P, Falcon R, et al. Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory: A possible role for histamine?. Behav Brain Res. 2016;313:226-232 pubmed publisher
    ..ii) Expression of the histamine-synthesizing enzyme, histidine decarboxylase (HDC) by western blot and (iii) thioperamide an H3 histamine receptor antagonist, on an object ..
  4. De Luca R, Suvorava T, Yang D, Baumgärtel W, Kojda G, Haas H, et al. Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. Neuropharmacology. 2016;106:102-15 pubmed publisher
    ..Single-cell RT-PCR revealed that all histaminergic neurons expressing histidine decarboxylase (HDC) also express H3R...
  5. Kempuraj D, Caraffa A, Ronconi G, Lessiani G, Conti P. Are mast cells important in diabetes?. Pol J Pathol. 2016;67:199-206 pubmed publisher
    ..inflammatory mediator generated by activated receptors of mast cells from the histamine-forming enzyme histidine decarboxylase (HDC), which can be activated by two inflammatory chemokines, RANTES and MPC1, when injected ..
  6. Ohtsu H, Seike M. Histamine and Histamine Receptors in Allergic Dermatitis. Handb Exp Pharmacol. 2017;241:333-345 pubmed publisher
    ..Histamine-deficient mice, with a knockout histidine decarboxylase (HDC) gene, were used to investigate the role of histamine in CACD and AD...
  7. Mondillo C, Varela M, Abiuso A, Vazquez R. Potential negative effects of anti-histamines on male reproductive function. Reproduction. 2018;155:R221-R227 pubmed publisher
    Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues...
  8. Chen A, Singh C, Oikonomou G, Prober D. Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. Eneuro. 2017;4: pubmed publisher
    ..Similar to rodent genetic studies, we found that zebrafish that lack histamine due to mutation of histidine decarboxylase (hdc) exhibit largely normal sleep/wake behaviors...
  9. Bjornsdottir Butler K, McCarthy S, Dunlap P, Benner R. Photobacterium angustum and Photobacterium kishitanii, Psychrotrophic High-Level Histamine-Producing Bacteria Indigenous to Tuna. Appl Environ Microbiol. 2016;82:2167-2176 pubmed publisher
    ..kishitanii and P. angustum had growth rates of 0.1 and 0.2 h(-1), respectively, and the activities of histidine decarboxylase (HDC) enzymes were 71% and 63%, respectively...
  10. Kimura S, Wang K, Yamada S, Guo X, Nabeshima A, Noguchi H, et al. CCL22/Macrophage-derived Chemokine Expression in Apolipoprotein E-deficient Mice and Effects of Histamine in the Setting of Atherosclerosis. J Atheroscler Thromb. 2015;22:599-609 pubmed publisher
    ..Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step. HDC knockout mice were compared with apoE/HDC double knockout mice...
  11. Laurino A, De Siena G, Saba A, Chiellini G, Landucci E, Zucchi R, et al. In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine. Eur J Pharmacol. 2015;761:130-4 pubmed publisher
    ..32 and 11μgkg(-1)). T1AM-induced hyperalgesia (1.32 and 11μgkg(-1)) was also evaluated in histidine decarboxylase (HDC(-/-)) mice...
  12. McGregor R, Shan L, Wu M, Siegel J. Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss. PLoS ONE. 2017;12:e0178573 pubmed publisher
    ..The number of neurons containing histidine decarboxylase (HDC), the histamine synthesizing enzyme, was 34% greater in the dark than in the light, but, like Hcrt, ..
  13. Umehara H, Fabbri R, Provensi G, Passani M. The hypophagic factor oleoylethanolamide differentially increases c-fos expression in appetite regulating centres in the brain of wild type and histamine deficient mice. Pharmacol Res. 2016;113:100-107 pubmed publisher
    ..to investigate if differences exist in OEA-induced c-Fos expression in several brain regions of fasted, histidine decarboxylase (HDC)-KO mice that do not synthesize histamine, and wild type (WT) littermates...
  14. Qian S, Wang Y, Zhang X. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019;67:411-417 pubmed publisher
    ..Pinnacle's automated sleep deprivation system was used to establish the female C57BL/6 mice SD model. Histidine decarboxylase inhibitor 4-bromo-3-hydroxybenzoic acid (BHOA), and antihistamine diphenhydramine (DPHM) were injected ..
  15. Martinel Lamas D, Rivera E, Medina V. Histamine H4 receptor: insights into a potential therapeutic target in breast cancer. Front Biosci (Schol Ed). 2015;7:1-9 pubmed
    ..to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production...
  16. Korosec P, Turner P, Silar M, Kopac P, Kosnik M, Gibbs B, et al. Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis. J Allergy Clin Immunol. 2017;140:750-758.e15 pubmed publisher
    ..the absolute number of circulating basophils; whole-blood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and serum markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 ..
  17. Kang M, Yoshimatsu H, Chiba S, Kurokawa M, Ogawa R, Tamari Y, et al. Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta. Am J Physiol. 1995;269:R1308-13 pubmed
    ..induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect ..
  18. Tanaka S, Takizawa N, Honda Y, Koike T, Oe S, Toyoda H, et al. Hypocretin/orexin loss changes the hypothalamic immune response. Brain Behav Immun. 2016;57:58-67 pubmed publisher
    ..Increases in the number of histidine decarboxylase (HDC)-positive cells and in Hdc mRNA expression were found in hypocretin/ataxin-3 mice, and this increase ..
  19. Dai Y, Wu D, Feng B, Hou W, Xu C, Ohtsu H, et al. Protective effect of carnosine on febrile seizures in immature mice. Neurosci Lett. 2015;588:95-100 pubmed publisher
    ..histidine was completely abolished by α-fluoromethylhistidine (α-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice...
  20. Alkan M, Machavoine F, Rignault R, Dam J, Dy M, Thieblemont N. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. J Diabetes Res. 2015;2015:965056 pubmed publisher
    ..To this end, we used mice (inactivated) knocked out for the gene encoding histidine decarboxylase, the unique histamine-forming enzyme, backcrossed on a NOD genetic background...
  21. Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al. Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell. 2017;21:747-760.e7 pubmed publisher
    ..physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc)...
  22. Nitta Y, Yasukata F, Kitamoto N, Ito M, Sakaue M, Kikuzaki H, et al. Inhibition of Morganella morganii Histidine Decarboxylase Activity and Histamine Accumulation in Mackerel Muscle Derived from Filipendula ulumaria Extracts. J Food Prot. 2016;79:463-7 pubmed publisher
    ..The efficacy of meadowsweet was assessed using two parameters: inhibition of Morganella morganii histidine decarboxylase (HDC) and inhibition of histamine accumulation in mackerel. Ellagitannins from F...
  23. Hirasawa N. Expression of Histidine Decarboxylase and Its Roles in Inflammation. Int J Mol Sci. 2019;20: pubmed publisher
    ..The histamine producing enzyme, histidine decarboxylase (HDC), is commonly induced at inflammatory sites during the late and chronic phases of both allergic and ..
  24. Diaz M, del Rio B, Ladero V, Redruello B, Fernández M, Martín M, et al. Isolation and typification of histamine-producing Lactobacillus vaginalis strains from cheese. Int J Food Microbiol. 2015;215:117-23 pubmed publisher
    ..the biogenic amine (BA) histamine is mainly produced by histidine decarboxylation catalysed by microbial histidine decarboxylase. The consumption of foods containing high concentrations of histamine can trigger adverse neurological, ..
  25. Yamaguchi H, Nakata K, Tatsumi M, Sugiki M, Miyano H, Mizukoshi T. Development of a novel l-histidine assay method using histamine dehydrogenase and a stable mutant of histidine decarboxylase. Anal Biochem. 2019;570:13-20 pubmed publisher
    ..Here, we describe a novel l-histidine quantitation assay using a combination of histidine decarboxylase (HDC) and histamine dehydrogenase (HDH) enzymes...
  26. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher
  27. Wada K, Kobayashi H, Moriyama A, Haneda Y, Mushimoto Y, Hasegawa Y, et al. A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy. Clin Pediatr Endocrinol. 2017;26:251-257 pubmed publisher
    ..This is the first case report of proven histological improvement after hormone replacement therapy. This suggested that pituitary-mediated hormones, especially cortisol, might be involved in the development of the bile ducts...
  28. Lei J, Deng X, Zhang J, Su L, Xu H, Liang H, et al. Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:72-6 pubmed publisher
    ..Recently, a heterozygous W317X mutation in the histidine decarboxylase gene (HDC) was reported to be responsible for TS in a two-generation pedigree...
  29. Anthony R, Kobayashi T, Wermeling F, Ravetch J. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011;475:110-3 pubmed publisher
    ..This novel DC-SIGN-T(H)2 pathway initiated by an endogenous ligand, sFc, provides an intrinsic mechanism for maintaining immune homeostasis that could be manipulated to provide therapeutic benefit in autoimmune diseases. ..
  30. Morrow S, Barr J, Rosehart H, Ulch S. Depression and hypomania symptoms are associated with high dose corticosteroids treatment for MS relapses. J Affect Disord. 2015;187:142-6 pubmed publisher
    ..Depressive and hypo(manic) symptoms are commonly associated with HDC for MS relapses. It is important for clinicians and MS patients to be aware of this risk. ..
  31. Pitkänen L, Montoro Bustos A, Murphy K, Winchester M, Striegel A. Quantitative characterization of gold nanoparticles by size-exclusion and hydrodynamic chromatography, coupled to inductively coupled plasma mass spectrometry and quasi-elastic light scattering. J Chromatogr A. 2017;1511:59-67 pubmed publisher
  32. Malzac P, Mattei M, Thibault J, Bruneau G. Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region. Hum Genet. 1996;97:359-61 pubmed
    Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the q15-q21 region of human chromosome 15 and to the E5-G region of murine chromosome 2...
  33. Morgan T, Montgomery K, Mason V, West R, Wang L, van de Rijn M, et al. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women. Kidney Int. 2006;70:306-14 pubmed
    ..b>Histidine decarboxylase (HDC), the enzyme that synthesizes histamine, was markedly upregulated in the mouse kidney during ..
  34. Cheng Y, Rondon G, Sanchez L, McMannis J, Couriel D, de Lima M, et al. Interleukin-2 and granulocyte-macrophage-colony-stimulating factor immunomodulation with high-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with metastatic breast cancer. Int J Hematol. 2009;90:627-634 pubmed publisher
    ..Estimated 3-year progression-free and overall survival rates were 31 and 57%. Our study suggested that the use of IL-2 and growth factors immunomodulation with HDC/AHST was feasible with comparable survival rates. ..
  35. Li J, Huang X, Wang Q, Jing S, Jiang H, Wei Z, et al. Pharmacokinetic properties and safety profile of histamine dihydrochloride injection in Chinese healthy volunteers: a phase I, single-center, open-label, randomized study. Clin Ther. 2015;37:2352-64 pubmed publisher
    ..Findings from this study support additional clinical trials for HDC using in Chinese patients. Chinese Clinical Trial Registry identifier: ChiCTR-ONC-13003954. ..
  36. Upadhyay A, Das C, Langley S, Murray K, Srivastava A, Shanmugam M. Heteronuclear Ni(ii)-Ln(iii) (Ln = La, Pr, Tb, Dy) complexes: synthesis and single-molecule magnet behaviour. Dalton Trans. 2016;45:3616-26 pubmed publisher
    ..5 Oe and Hdc = 0 Oe) which is a characteristic signature of a single-molecule magnet behaviour. ..
  37. Witkowski L, Goudie C, Ramos P, Boshari T, Brunet J, Karnezis A, et al. The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. Gynecol Oncol. 2016;141:454-460 pubmed publisher
    ..The large fraction of SMARCA4 germline mutations carriers warrants genetic counseling for all patients. ..
  38. Boudin L, Chabannon C, Sfumato P, Sabatier R, Bertucci F, Tarpin C, et al. [Impact of Her2 and BRCA1/2 status in high-dose chemotherapy and autologous stem cells transplantation in the treatment of breast cancer: The Institut Paoli Calmettes' experience]. Bull Cancer. 2017;104:332-343 pubmed publisher
    ..301). The HDC-ACSH does not change the prognosis value of IHC subtype in breast cancer patients. ..
  39. Wang K, Wang Y, Wang X, Ren Q, Han S, Ding L, et al. Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach. J Transl Med. 2018;16:11 pubmed publisher
    ..These findings might have bright prospect in future in developing novel biomimetic peptides with preventive and therapeutic benefits for childhood caries. ..
  40. He M, Zhang Q, Deng C, Jin T, Song X, Wang H, et al. Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity. Psychoneuroendocrinology. 2017;85:190-199 pubmed publisher
    ..This study examined the effect of olanzapine on key molecules of the histaminergic system, including histidine decarboxylase (HDC), H1 receptor (H1R) and H3 receptor (H3R), in the brain at different stages of olanzapine-induced ..
  41. Kim K, Kim J, Ji E, Jang J, Kim J, Kwon J, et al. Psychometric analysis of the Korean version of the high-dose chemotherapy specific quality of life questionnaire module from the European Organization for Research and Treatment of Cancer (EORTC QLQ-HDC29). Qual Life Res. 2016;25:881-90 pubmed publisher
    ..The QLQ-HDC29 is generally reliable and adequate to assess QoL in Korean patients undergoing HDC followed by HSCT. ..
  42. Chorazy S, Rams M, Nakabayashi K, Sieklucka B, Ohkoshi S. White Light Emissive Dy(III) Single-Molecule Magnets Sensitized by Diamagnetic [Co(III) (CN)6 ](3-) Linkers. Chemistry. 2016;22:7371-5 pubmed publisher
  43. Landry B, François Z, Wang R, Taicheng Z, Li Y. Viability and Stress Response of Putative Probiotic Lactobacillus plantarum Strains in Honey Environment. Probiotics Antimicrob Proteins. 2018;10:629-637 pubmed publisher
    ..The Lactobacillus plantarum GLP56, Lactobacillus plantarum GLA51, and Lactobacillus plantarum GGU strains exposed to honey can withstand acidic environmental stress but their viability declines over time. ..
  44. Roman M, Rigo C, Castillo Michel H, Munivrana I, Vindigni V, Mičetić I, et al. Hydrodynamic chromatography coupled to single-particle ICP-MS for the simultaneous characterization of AgNPs and determination of dissolved Ag in plasma and blood of burn patients. Anal Bioanal Chem. 2016;408:5109-24 pubmed publisher
    ..Graphical Abstract Simplified scheme of the combined analytical approach adopted for studying the chemical dynamics of AgNPs in human plasma/blood. ..
  45. Chang Y, Shih Y, Su C, Ho H. Comparison of three analytical methods to measure the size of silver nanoparticles in real environmental water and wastewater samples. J Hazard Mater. 2017;322:95-104 pubmed publisher
    ..The findings of this study propose a preliminary technique to more accurately determine the Ag NPs in aquatic environments and to use this knowledge to evaluate the environmental impact of manufactured NPs. ..
  46. Martínez Moreno J, Reyes Ortiz A, Lage Sánchez J, Sánchez Gallegos P, Garcia Caballero M. Timeline of Intestinal Adaptation After Malabsortive Surgery: Effect of Luminal Nutrients, Biliopancreatic Secretion, and Glutamine Supplementation. Obes Surg. 2017;27:3133-3141 pubmed publisher
    ..We measured the height and width of intestinal villi, histidine decarboxylase (HDC) activity, and amount of HDC messenger RNA (mRNA) (standard diet or a diet supplemented with ..
  47. Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, et al. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018;142:1173-1184 pubmed publisher
    ..Histamine is synthesized by decarboxylating the amino acid histidine, a reaction catalyzed by the histidine decarboxylase (Hdc) gene-encoded enzyme HDC. However, regulation of the Hdc gene in mast cells is poorly understood...
  48. Altuntaş E, Dogan O, Sarac B, Turgut N, Durmuş K, Akyol M. The effects of mometasone furoate and strontium chloride in a rat model of allergic rhinitis. Ear Nose Throat J. 2018;97:E1-E7 pubmed
    ..These studies have revealed that allergic rhinitis can be successfully and safely treated with strontium-chloride-containing products, thus offering a potential new treatment strategy. ..
  49. Bencsáth M, Paloczi K, Szalai C, Szenthe A, Szeberenyi J, Falus A. Histidine decarboxylase in peripheral lymphocytes of healthy individuals and chronic lymphoid leukemia patients. Pathol Oncol Res. 1998;4:121-4 pubmed
    b>Histidine decarboxylase (HDC), the only enzyme capable of synthetizing histamine, has been found in many proliferating cells and tissues suggesting a role of histamine in cellular proliferation...
  50. O Sullivan D, Fallico V, O Sullivan O, McSweeney P, Sheehan J, Cotter P, et al. High-throughput DNA sequencing to survey bacterial histidine and tyrosine decarboxylases in raw milk cheeses. BMC Microbiol. 2015;15:266 pubmed publisher
    ..This approach can be used to detect amine producing communities not only in food matrices but also in the production environment itself. ..
  51. Resende L, Truong M, Gomez A, Jones D. Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Dev Biol. 2017;424:10-17 pubmed publisher
  52. Li Z, Liu J, Tang F, Liu Y, Waldum H, Cui G. Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas. APMIS. 2008;116:1034-42 pubmed publisher
    ..area of north China were used to assess changes in microvessel density (MVD) and non-mast cell L-histidine decarboxylase (HDC) (the only rate-limiting enzyme that catalyzes the formation of histamine from L-histidine) ..
  53. Adeleye A. Clinical and Radiologic Outcome of a Less Invasive, Low-Cost Surgical Technique of Osteoplastic Decompressive Craniectomy. J Neurol Surg A Cent Eur Neurosurg. 2016;77:167-75 pubmed publisher
    ..Analysis of the clinical data in a consecutive prospective cohort of patients with potentially fatal TBI who underwent this surgical procedure showed a good outcome in at least two thirds. ..
  54. Hoffman G, Koban M. Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats. PLoS ONE. 2016;11:e0152252 pubmed publisher
    ..We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because ..
  55. Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C. Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Transl Psychiatry. 2017;7:e1013 pubmed publisher
    ..dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (Hdc) gene represent a promising pathophysiologically grounded model...
  56. Masini E, Fabbroni V, Giannini L, Vannacci A, Messerini L, Perna F, et al. Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage. Inflamm Res. 2005;54 Suppl 1:S80-1 pubmed
  57. Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, et al. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis. Intensive Care Med Exp. 2016;4:36 pubmed
    ..b>Histidine decarboxylase (HDC) gene knockout (HDC-/-) mice, histamine H1-/H2-receptor gene-double ..
  58. Perez C, Wu X, Amsbaugh M, Gosain R, Claudino W, Yusuf M, et al. High-dose versus weekly cisplatin definitive chemoradiotherapy for HPV-related oropharyngeal squamous cell carcinoma of the head and neck. Oral Oncol. 2017;67:24-28 pubmed publisher
    ..HPV-related SCCOPx treated with definitive CRT with either HDC or WC had similar toxicity profile. HDC had better EFS when compared with WC and this seems to be driven by increased distant failure rates, although the OS was similar. ..
  59. Iioka F, Toda Y, Nagai Y, Akasaka T, Shimomura D, Tsuda K, et al. Delayed Development of Hemolytic Anemia with Fragmented Red Blood Cells and Cardiac and Renal Impairments after High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Malignant Lymphoma. Acta Haematol. 2017;138:152-161 pubmed publisher
    ..The close monitoring of laboratory abnormalities and persistent treatment with cardiovascular agents and diuretics are the mainstay for the management of this condition...
  60. Costa A, Cristiano C, Cassano T, Gallelli C, Gaetani S, Ghelardini C, et al. Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide. Neuropharmacology. 2018;135:234-241 pubmed publisher
    ..p.) as an antidepressant drug in histidine decarboxylase null (HDC-/-) mice and HDC+/+ littermates, as well as in PPAR-α+/+ and ..
  61. Aichberger K, Mayerhofer M, Vales A, Krauth M, Gleixner K, Bilban M, et al. The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells. Blood. 2006;108:3538-47 pubmed
    ..The CML-specific oncoprotein BCR/ABL was found to promote expression of histidine decarboxylase (HDC) and synthesis of histamine in Ba/F3 cells...
  62. Boudin L, Chabannon C, Sfumato P, Sabatier R, Bertucci F, Tarpin C, et al. Immunohistochemical subtypes predict survival in metastatic breast cancer receiving high-dose chemotherapy with autologous haematopoietic stem cell transplantation. Eur J Cancer. 2016;57:118-26 pubmed publisher
    ..OS favourably compares with data available in the literature on similar groups of patients. These findings provide additional information and options for patients with MBC and who could potentially benefit of HDC-AHSCT. ..
  63. Sander F, Nilsson M, Rydström A, Aurelius J, Riise R, Movitz C, et al. Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy. Cancer Immunol Immunother. 2017;66:1473-1484 pubmed publisher
    ..Our results suggest that immunotherapy with HDC/IL-2 in AML entails induction of immunosuppressive Tregs that may be targeted for improved anti-leukemic efficiency. ..
  64. Hanieh H, Hairul Islam V, Saravanan S, Chellappandian M, Ragul K, Durga A, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017;814:178-186 pubmed publisher
    ..A special emphasis was directed toward histidine decarboxylase (HDC) and other pro-allergic and pro-inflammatory mediators...
  65. Ohtsuka T, Ohtake H, Matsuzaki S, Ichimura K, Ichikawa A, Yamakage A, et al. Upregulation of histidine decarboxylase mRNA expression in scleroderma skin. Arch Dermatol Res. 2001;293:171-7 pubmed
    ..Possible involvement of histamine and histidine decarboxylase (HDC), the synthesizing enzyme for histamine, in the formation of the skin abnormalities in SSc was ..
  66. Chen K, Wang C, Fan Y, Xie Y, Yin Z, Xu Z, et al. Model design for screening effective Antihyperlipidemic drugs using zebrafish system. Pak J Pharm Sci. 2017;30:1697-1707 pubmed
    ..The high-fat zebrafish model induced by HFD-fed was available and successful, besides, the Oil red O staining may be an available and rapid method for screening lipid-lowering drugs...
  67. Fossey M, Li H, Afzal S, Carret A, Eisenstat D, Fleming A, et al. Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature. J Neurooncol. 2017;132:155-162 pubmed publisher
    ..While 1/3 of ATRT occurs within the first year of life, a large proportion only received palliative therapy. Even when actively treated, children??6 months fare worse. Some selected patients benefit from HDC. ..
  68. Ueda Y, Aoyagi H, Tajima T. A newborn with combined pituitary hormone deficiency developing shock and sludge. J Pediatr Endocrinol Metab. 2017;: pubmed publisher
    ..In newborns with CPHD, severe central adrenal insufficiency might induce cardiogenic shock after birth. Early diagnosis and intervention are necessary...
  69. Ercan Sencicek A, Stillman A, Ghosh A, Bilguvar K, O Roak B, Mason C, et al. L-histidine decarboxylase and Tourette's syndrome. N Engl J Med. 2010;362:1901-8 pubmed publisher
    ..pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis...
  70. Sanchez Jimenez F, Pino Angeles A, Rodriguez Lopez R, Morales M, Urdiales J. Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications. Pharmacol Res. 2016;114:90-102 pubmed publisher
    Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively...
  71. Cherukula K, Nurunnabi M, Jeong Y, Lee Y, Park I. A targeted graphene nanoplatform carrying histamine dihydrochloride for effective inhibition of leukemia-induced immunosuppression. J Biomater Sci Polym Ed. 2017;:1-16 pubmed publisher
    ..In vitro ROS detection assays proved that the HDC loaded graphene nanoplatform could effectively inhibit ROS and thus prevent the immunosuppression caused by leukemic cells...
  72. Bruneau G, Nguyen V, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum Genet. 1992;90:235-8 pubmed
    The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase...
  73. Yang J, Ma Y, Zhang P, Chen H, Liu Z, Qin H. Histidine decarboxylase is identified as a potential biomarker of intestinal mucosal injury in patients with acute intestinal obstruction. Mol Med. 2011;17:1323-37 pubmed publisher
    ..Among the six proteins, histidine decarboxylase (HDC) and ceruloplasmin (CP) were elevated significantly in patients with STR-IO, compared with patients ..
  74. Komori H, Nitta Y, Ueno H, Higuchi Y. Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:675-7 pubmed publisher
    The core domain of a human histidine decarboxylase mutant was purified and cocrystallized with the inhibitor L-histidine methyl ester. Using synchrotron radiation, a data set was collected from a single crystal at 100 K to 1...
  75. Laszlo V, Rothe G, Hegyesi H, Szeberényi J, Orso E, Schmitz G, et al. Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. Inflamm Res. 2001;50:428-34 pubmed
    In this study the expression of histidine decarboxylase (HDC), the pivotal enzyme in histamine formation and the effect of endogenously produced histamine on differentiation antigens was examined during in vitro differentiation of human ..
  76. Bashey A, Sundaram S, Corringham S, Jones V, Lancaster D, Silva Gietzen J, et al. Use of capecitabine as first-line therapy in patients with metastatic breast cancer relapsing after high-dose chemotherapy and autologous stem cell support. Clin Oncol (R Coll Radiol). 2001;13:434-7 pubmed
    ..Five progressed after remissions that lasted between 63 and 252 days. Oral capecitabine is an active and well-tolerated agent when used alone as first-line therapy in patients who have relapsed after HDC-ASCS for MBC...
  77. Raychowdhury R, Fleming J, McLaughlin J, Bulitta C, Wang T. Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter. Biochem Biophys Res Commun. 2002;297:1089-95 pubmed
    In human gastric cancer cells the human histidine decarboxylase gene is regulated by gastrin through two overlapping cis-acting elements known as gastrin response elements 1&2 (GAS-RE1, GAS-RE2) [J. Biol. Chem. 274 (1999) 20961]...
  78. Francis H, Demorrow S, Venter J, Onori P, White M, Gaudio E, et al. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Gut. 2012;61:753-64 pubmed publisher
    In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression...
  79. Chamieh J, Leclercq L, Martin M, Slaoui S, Jensen H, Ostergaard J, et al. On the limits in size of Taylor dispersion analysis: representation of the different hydrodynamic regimes and application to the size-characterization of cubosomes. Anal Chem. 2017;: pubmed publisher
    ..Finally, application of TDA to the sizing of large real-life solutes is proposed taking cubosomes as new drug nano-carriers of potential interest for drug delivery purposes...
  80. Choi S, Lee K, Kim H, Park I, Kang H, Shin H, et al. Effects of structurally stabilized EGF and bFGF on wound healing in type I and type II diabetic mice. Acta Biomater. 2018;66:325-334 pubmed publisher
    ..Consequentially, these ST-EGF and ST-bFGF-loaded HCD matrix may be used as future therapeutic agents in patients with diabetic foot ulcers. ..
  81. Belke K, Baron J, Schmutzler W, Zwadlo Klarwasser G. Histidine decarboxylase expression in human monocytes, macrophages and macrophage subsets. Int Arch Allergy Immunol. 1999;118:353-4 pubmed
  82. Ai W, Liu Y, Langlois M, Wang T. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements. J Biol Chem. 2004;279:8684-93 pubmed
    b>Histidine decarboxylase (HDC) is the enzyme that catalyzes the conversion of histidine to histamine, a bioamine that plays an important role in allergic responses, inflammation, neurotransmission, and gastric acid secretion...
  83. Brew O, Lakasing L, Sullivan M. Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae. Placenta. 2007;28:585-7 pubmed
  84. Lee B, Zhu X, Rupprecht S, Lanagan M, Yang Q, Chen W. Large improvement of RF transmission efficiency and reception sensitivity for human in vivo31P MRS imaging using ultrahigh dielectric constant materials at 7T. Magn Reson Imaging. 2017;42:158-163 pubmed publisher
    ..The uHDC technology could provide an efficient, cost-effective engineering solution for achieving high detection sensitivity and concurrently minimizing tissue heating concern for human MRS and MRI applications. ..
  85. De Sousa S, Meyer E, Rankin W, Brautigan P, Burt M, Torpy D. Vasculogenic hyperprolactinemia: severe prolactin excess in association with internal carotid artery aneurysms. Pituitary. 2017;20:676-682 pubmed publisher
    ..This may be mediated by an endothelial factor capable of paracrine stimulation of lactotrophs; however, angiotensin II, substance P, histamine and PRLH appear unlikely to be causative. ..
  86. Mamune Sato R, Yamauchi K, Tanno Y, Ohkawara Y, Ohtsu H, Katayose D, et al. Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells. Eur J Biochem. 1992;209:533-9 pubmed
    L-Histidine decarboxylase (HisDC) is the enzyme catalyzing the formation of histamine from L-histidine. HisDC activity is expressed specifically in mast cells/basophils, endocrine cells in stomach, and histaminergic neurons in brain...
  87. Szeberényi J, Pallinger E, Todorova R, Falus A. Detection of histidine decarboxylase in peripheral blood leukocytes by flow cytometry. Inflamm Res. 1999;48 Suppl 1:S87-9 pubmed
  88. Schoch L, Asiama A, Zahurak M, Shanbhag S, Hurtt J, Sawyer K, et al. Pharmacokinetically-targeted dosed everolimus maintenance therapy in lymphoma patients. Cancer Chemother Pharmacol. 2018;81:347-354 pubmed publisher
    ..Pharmacokinetically-targeted dosing appears to increase everolimus tolerability. This finding may be applicable to other patient populations. ..
  89. Kennedy L, Hargrove L, Demieville J, Bailey J, Dar W, Polireddy K, et al. Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling. Am J Pathol. 2018;188:600-615 pubmed publisher
    ..Wild-type (WT) and l-histidine decarboxylase (Hdc-/-) mice were fed a control diet or an HFD coupled with a high fructose corn syrup ..
  90. Bencsáth M, Gidali J, Brandes L, Falus A. Murine and human hematopoietic colony formation: a possible regulatory role for intracellular histamine. Acta Biol Hung. 2002;53:299-306 pubmed
    ..We detected mRNA and protein expression of histidine decarboxylase (HDC), the only enzyme responsible for histamine synthesis both in normal bone marrow progenitor cells ..
  91. Rybakowska I, Milczarek R, Slominska E, Smolenski R. Effect of decaffeinated coffee on function and nucleotide metabolism in kidney. Mol Cell Biochem. 2018;439:11-18 pubmed publisher
    ..HDC leads to increased activity of ecto5'-nucleotidase in kidney cortex that translates to increase in concentration of adenosine. Surprisingly this caused improved kidney excretion function. ..
  92. Wu X, Yang J, Na T, Zhang K, Davidoff A, Yuan B, et al. RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA. PLoS ONE. 2017;12:e0182961 pubmed publisher
    ..Interestingly, the STING protein is not significantly affected by dsDNA in non-HDC HEK293 cells. Our study thus has identified a novel signaling pathway for regulating STING in HDCs. ..