histamine N methyltransferase


Gene Symbol: histamine N methyltransferase
Description: histamine N-methyltransferase
Alias: HMT, HNMT-S1, HNMT-S2, MRT51, histamine N-methyltransferase
Species: human

Top Publications

  1. Yan L, Galinsky R, Bernstein J, Liggett S, Weinshilboum R. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics. 2000;10:261-6 pubmed
  2. Chen G, Wang H, Wang W, Xu Z, Zhou G, He F, et al. Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes. Pharmacogenetics. 2003;13:389-97 pubmed
  3. Chen G, Wang W, Xu Z, Zhu B, Wang L, Zhou G, et al. Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population. Clin Chim Acta. 2003;334:179-83 pubmed
    ..Additional unknown genetic or epigenetic factors should also play important roles in the regulation of HNMT activity. ..
  4. Kennedy M, Loehle J, Griffin A, Doll M, Kearns G, Sullivan J, et al. Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children. Pharmacotherapy. 2008;28:1495-501 pubmed publisher
    ..Additional longitudinal studies will be required to assess the relationship between genotype, disease severity, and antihistamine response. ..
  5. Schwartz M, Benci J, Selote D, Sharma A, Chen A, Dang H, et al. Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans. PLoS ONE. 2010;5:e9564 pubmed publisher
    ..In this regard, half-molecule ATP-binding cassette (ABC) transporters of the HMT-1 subfamily are required for cadmium (Cd) detoxification...
  6. Palada V, Terzic J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, et al. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiol Aging. 2012;33:836.e1-3 pubmed publisher
    ..65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD. ..
  7. Agundez J, Luengo A, Herraez O, Martinez C, Alonso Navarro H, Jimenez Jimenez F, et al. Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease. Neuromolecular Med. 2008;10:10-6 pubmed
    ..0001). These results, combined with previous findings indicating alterations in histamine levels in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with the risk for PD. ..
  8. Sharma S, Mann D, Singh T, Ghosh B. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. J Hum Genet. 2005;50:611-7 pubmed
    ..Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population. ..
  9. Kang Y, Kim S, Cho B, Ye Y, Hur G, Park H. Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. Allergy. 2009;64:213-21 pubmed publisher
    ..The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of AICU. ..

More Information


  1. Marasović Šušnjara I, Palada V, Marinovic Terzic I, Mimica N, Marin J, Muck Seler D, et al. No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease. Neurosci Lett. 2011;489:119-21 pubmed publisher
    ..5% among AD patients and 13.4% for healthy controls (p=0.26, X(2)=1.25). Our results indicate lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease. ..
  2. Horton J, Sawada K, Nishibori M, Zhang X, Cheng X. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure. 2001;9:837-49 pubmed
    ..The interactions between HNMT and quinacrine provide the first structural insights into a large group of pharmacologic HNMT inhibitors and their mechanisms of inhibition. ..
  3. Chen G, Zhu B, Nie W, Xu Z, Tan Z, Zhou G, et al. Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer. Inflamm Res. 2004;53:484-8 pubmed
    ..This study provided no evidence for the involvement of HNMT polymorphisms in the susceptibility to GU. ..
  4. Garcia Martin E, García Menaya J, Sanchez B, Martinez C, Rosendo R, Agúndez J. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. Clin Exp Allergy. 2007;37:1175-82 pubmed
    ..However, patients carrying the His645Asp polymorphism of ABP1 are more prone to developing symptoms with lower IgE levels. ..
  5. Garcia Martin E, Mendoza J, Martinez C, Taxonera C, Urcelay E, Ladero J, et al. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. World J Gastroenterol. 2006;12:615-20 pubmed
    ..The His645Asp polymorphism of the histamine metabolising enzyme ABP1 is related to severity of ulcerative colitis. ..
  6. Ledesma M, Garcia Martin E, Alonso Navarro H, Martinez C, Jimenez Jimenez F, Benito Leon J, et al. The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. Neuromolecular Med. 2008;10:356-61 pubmed publisher
  7. Oroszi G, ENOCH M, Chun J, Virkkunen M, Goldman D. Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations. Alcohol Clin Exp Res. 2005;29:303-9 pubmed
    ..070) after correcting for alcoholism diagnosis. Decreased levels of brain histamine consequent to the Thr105 allele may result in higher levels of anxiety and, as a consequence, vulnerability to alcoholism. ..
  8. Deindl P, Peri Jerkan S, Deichmann K, Niggemann B, Lau S, Sommerfeld C, et al. No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. Pediatr Allergy Immunol. 2005;16:40-2 pubmed
    ..We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children. ..
  9. Keeling B, Vilariño Güell C, Soto Ortolaza A, Ross O, Uitti R, Rajput A, et al. Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor. Parkinsonism Relat Disord. 2010;16:112-4 pubmed publisher
  10. Preuss C, Wood T, Szumlanski C, Raftogianis R, Otterness D, Girard B, et al. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Mol Pharmacol. 1998;53:708-17 pubmed
    ..These observations will make it possible to test the hypothesis that genetic polymorphisms for HNMT may play a role in the pathophysiology of human disease. ..
  11. Kellermayer B, Polgar N, Pal J, Banati M, Maasz A, Kisfali P, et al. Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase. Hum Immunol. 2013;74:1701-4 pubmed publisher
    ..Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine modulates immune responses and plays a role in the pathogenesis of autoimmune disorders...
  12. Chen G, Xu Z, Wang W, Wang G, Zhou G, Wang D, et al. Analysis of the C314T and A595G mutations in histamine N-methyltransferase gene in a Chinese population. Clin Chim Acta. 2002;326:163-7 pubmed
  13. Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP). Biochem Pharmacol. 2002;64:699-710 pubmed
    ..These results represent an additional step in the definition of molecular genetic mechanisms involved in the regulation of this important autacoid-metabolizing enzyme in humans. ..
  14. Maw H, Zeng X, Campbell S, Taub M, Teitelbaum A. N-Methylation of BI 187004 by Thiol S-Methyltransferase. Drug Metab Dispos. 2018;46:770-778 pubmed publisher
    ..Overall, using BI 187004 as a substrate, this study demonstrates a novel TMT-mediated N-methylation biotransformation and an HNMT-mediated regioselective N-methylation. ..
  15. Stasiak A, Mussur M, Unzeta M, Samadi A, Marco Contelles J, Fogel W. Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia. Curr Pharm Des. 2014;20:161-71 pubmed
    ..The activities of MAOs, AChE and histamine N-methyltransferase (HMT), as well as cerebral amines concentrations were assayed...
  16. Kang M, Yoshimatsu H, Chiba S, Kurokawa M, Ogawa R, Tamari Y, et al. Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta. Am J Physiol. 1995;269:R1308-13 pubmed
    ..The same dose of IL-1 beta also increased activity of HDC and histamine-N-methyltransferase (HMT)...
  17. Herbette M, Mercier M, Michal F, Cluet D, Burny C, Yvert G, et al. The C. elegans SET-2/SET1 histone H3 Lys4 (H3K4) methyltransferase preserves genome stability in the germline. DNA Repair (Amst). 2017;57:139-150 pubmed publisher
    ..The conserved SET1/MLL family of histone methyltransferases (HMT) catalyzes methylation of histone H3 on Lysine 4 (H3K4), a histone modification universally associated with ..
  18. Kanwal R, Datt M, Liu X, Gupta S. Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. PLoS ONE. 2016;11:e0162956 pubmed publisher
    ..SssI enzyme. Furthermore, a marked decrease in HMT activity and a decrease in EZH2 protein expression and trimethylation of H3K27 were noted in histones isolated from ..
  19. Camilleri M, Carlson P, Valentin N, Acosta A, O Neill J, Eckert D, et al. Pilot study of small bowel mucosal gene expression in patients with irritable bowel syndrome with diarrhea. Am J Physiol Gastrointest Liver Physiol. 2016;311:G365-76 pubmed publisher
    ..In conclusion, altered transcriptome (and to lesser extent protein) expression of ion transport, barrier, immune, and mast cell mechanisms in small bowel may reflect different alterations in function and deserves further study in IBS-D. ..
  20. Hirayama M, Tomita Y, Yuno A, Tsukamoto H, Senju S, Imamura Y, et al. An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs. Oncoimmunology. 2016;5:e1123368 pubmed publisher
    ..These findings suggest the potential usefulness of IMP-3-LPs in propagating both Th cells and CTLs and may have implications for IMP-3-LPs-based cancer immunotherapy. ..
  21. Dobson T, Hatcher R, Swaminathan J, Das C, Shaik S, Tao R, et al. Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation. Mol Cancer Res. 2017;15:1073-1084 pubmed publisher
    ..and pharmacologic approaches were employed to identify a specific role for G9a, a histone methyltransferase (HMT), in promoting methylation of histone H3 lysine-9 (H3K9) mono- and dimethylation, and surprisingly trimethylation, ..
  22. Bennuru S, Lustigman S, Abraham D, Nutman T. Metabolite profiling of infection-associated metabolic markers of onchocerciasis. Mol Biochem Parasitol. 2017;215:58-69 pubmed publisher
    ..In addition, putative metabolites were identified based on KEGG (51), HMDB (37) and HMT (6) databases...
  23. Zuma A, Santos J, Mendes I, de Souza W, Machado C, Motta M. Chaetocin-A histone methyltransferase inhibitor-Impairs proliferation, arrests cell cycle and induces nucleolar disassembly in Trypanosoma cruzi. Acta Trop. 2017;170:149-160 pubmed publisher
    ..In the present study, the effects of chaetocin, a HMT inhibitor, on T. cruzi epimastigote proliferation, viability, ultrastructure and cell cycle were investigated...
  24. Li X, Li C, Li X, Cui P, Li Q, Guo Q, et al. Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions. J Diabetes Res. 2016;2016:3853242 pubmed publisher
    ..We evaluated the roles of HKme and histone methyltransferase (HMT) SET7/9 in p21 gene expression in glomeruli of diabetic rats and in high glucose- (HG-) treated rat mesangial cells ..
  25. Vanni V, Puglisi F, Bonsi P, Ponterio G, Maltese M, Pisani A, et al. Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia. Exp Neurol. 2015;271:457-67 pubmed publisher
    ..mouse strains, heterozygous torsinA knockout mice (Tor1a+/-) and human ΔGAG mutant torsinA transgenic mice (hMT), the anatomical abnormalities in the cerebellum, during a critical age for synaptogenesis (postnatal day 14, P14)...
  26. Yamada A, Shimura C, Shinkai Y. Biochemical validation of EHMT1 missense mutations in Kleefstra syndrome. J Hum Genet. 2018;63:555-562 pubmed publisher
    ..Therefore, we validated these two mutations by performing in vitro histone methyltransferase (HMT) activity assay and found that C1073Y and R1197W mutations severely affected the HMT activity...
  27. Jiang F, Beauchamp M, Fine I. Re-examining overlap between tactile and visual motion responses within hMT+ and STS. Neuroimage. 2015;119:187-96 pubmed publisher
    ..Although several studies have reported tactile responses overlapping with hMT+, many used group average analyses, leaving it unclear whether these responses were restricted to subregions of hMT+..
  28. Drozak J, Piecuch M, Poleszak O, Kozlowski P, Chrobok L, Baelde H, et al. UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase. J Biol Chem. 2015;290:17190-205 pubmed publisher
    ..We conclude that UPF0586 is mammalian carnosine N-methyltransferase and hypothesize that it may also serve as a peptide or protein methyltransferase in eukaryotes. ..
  29. Erlikhman G, Caplovitz G. Decoding information about dynamically occluded objects in visual cortex. Neuroimage. 2017;146:778-788 pubmed publisher
    ..such as ventral, lateral, and temporal occipital areas (VO, LO, and TO) as well as the functionally defined LOC and hMT+...
  30. Saito C, Ishiyama K, Yamazaki H, Zaimoku Y, Nakao S. Hypomegakaryocytic thrombocytopenia (HMT): an immune-mediated bone marrow failure characterized by an increased number of PNH-phenotype cells and high plasma thrombopoietin levels. Br J Haematol. 2016;175:246-251 pubmed publisher
    Patients with mild hypomegakaryocytic thrombocytopenia (HMT) that does not meet the diagnostic criteria for a definite disease entity may potentially progress to aplastic anaemia (AA) that is refractory to therapy...
  31. Lee Y, Park S, Lee I, Ahn J, Kim H, Chung J, et al. Report on outcomes of hypomethylating therapy for analyzing prognostic value of Revised International Prognostic Scoring System for patients with lower-risk myelodysplastic syndromes. Ann Hematol. 2016;95:1795-804 pubmed publisher
    ..this study evaluates the prognostic value of revised IPSS with the response to hypomethylating therapy (HMT)...
  32. Ajina S, Rees G, Kennard C, Bridge H. Abnormal contrast responses in the extrastriate cortex of blindsight patients. J Neurosci. 2015;35:8201-13 pubmed publisher
    ..This residual vision is most robust for moving stimuli, suggesting a role for motion area hMT+...
  33. Tongsook C, Niederhauser J, Kronegger E, Straganz G, Macheroux P. Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability. Biochim Biophys Acta Mol Basis Dis. 2017;1863:188-199 pubmed publisher
    ..This finding rationalizes the gradual loss of enzymatic activity observed in the L208 variants. ..
  34. Vatamaniuk O, Bucher E, Sundaram M, Rea P. CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans. J Biol Chem. 2005;280:23684-90 pubmed
    ..Heterologous expression of cehmt-1 in S. pombe alleviates the Cd2+-hypersensitivity of hmt- mutants concomitant with the localization of CeHMT-1 to the vacuolar membrane...
  35. Hu Y, Chen M, Wang Z, Lan Y, Tang L, Liu M, et al. Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomed Chromatogr. 2017;31: pubmed publisher
    Humantenmine (HMT), the most toxic compound isolated from Gelsemium elegans Benth, is a well-known active herbal compound...
  36. Ye X, Lu F, Yao T, Gan R, Sui Z. Optimization of reaction conditions for improving nutritional properties in heat moisture treated maize starch. Int J Biol Macromol. 2016;93:34-40 pubmed publisher
    Impact of heat-moisture treatment (HMT) on nutritional properties of normal maize starch (NMS) under various reaction conditions was investigated...
  37. Hon Y, Jusko W, Spratlin V, Jann M. Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism. J Clin Pharmacol. 2006;46:408-17 pubmed
    ..031 and .033, respectively, Wilcoxon rank sum test). Subjects who are heterozygous for the T314 variant allele thus appeared less sensitive to the suppressive effects of methylprednisolone on cortisol secretion. ..
  38. Bala A, Nguyen H, Hellstrom W. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev. 2018;6:29-34 pubmed publisher
    ..Further studies are warranted to investigate the prevalence, pathophysiology, and treatment of PSSD. Bala A, Nguyen HMT, Hellstrom WJG. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev 2018;6:29-34.
  39. Chen M, Xu L, Chang L, Yin P, Jiang Z. Reduction of Motion Sickness Through Targeting Histamine N-Methyltransferase in the Dorsal Vagal Complex of the Brain. J Pharmacol Exp Ther. 2018;364:367-376 pubmed publisher
    ..In conclusion, HNMT expression in the brain stem is inversely correlated with MS development. Increasing HNMT expression or stimulating its activity in the DVC could inhibit MS. ..
  40. Dobenecker M, Park J, Marcello J, McCabe M, Gregory R, Knight S, et al. Signaling function of PRC2 is essential for TCR-driven T cell responses. J Exp Med. 2018;215:1101-1113 pubmed publisher
    Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output...
  41. Girard B, Otterness D, Wood T, Honchel R, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. Mol Pharmacol. 1994;45:461-8 pubmed
    ..3, 3.8, and 4.0 kilobases in length. Cloning of a cDNA for HNMT may now make it possible to determine the molecular basis for the HNMT genetic polymorphism in humans. ..
  42. Xu C, Zhu S, Wang M, Guo S, Sun X, Cheng R, et al. Pathway analysis of differentially expressed genes in human esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2015;19:1652-61 pubmed
    ..Investigation of the mechanism underlying ESCC can provide a direction for the clinical prevention and treatment of ESCC. ..
  43. Tan C, Ng Y, Ong W. Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. Mol Neurobiol. 2016;53:3854-3872 pubmed publisher
    ..In addition, co-treatment of with histone methyltransferase (HMT) inhibitor, 5'-deoxy-5'-methylthioadenosine (MTA) suppressed TSA-induced cPLA2α upregulation...
  44. Nguyen H, Bala A, Gabrielson A, Hellstrom W. Post-Orgasmic Illness Syndrome: A Review. Sex Med Rev. 2018;6:11-15 pubmed publisher
    ..Nguyen HMT, Bala A, Gabrielson AT, Hellstrom WJG. Post-Orgasmic Illness Syndrome: A Review. Sex Med Rev 2018;6:11-15.
  45. Ma X, Wang J, Wang J, Ma C, Gao X, Patriub V, et al. The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. Oncotarget. 2017;8:4062-4078 pubmed publisher
    ..indicated JAZF1-SUZ12 destabilized PRC2 components EZH2 and EED, resulting in decreased histone methyl transferase (HMT) activity, which was confirmed by in vitro studies using reconstituted PRC2 and nucleosome array substrates...
  46. Li K, Li G, Bradbury L, Hanson A, Bruner S. Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. Biochem J. 2016;473:277-84 pubmed publisher
    ..The mmuM gene product from Escherichia coli is an archetypal HMT family protein and contains a predicted zinc-binding motif in the enzyme active site...
  47. Ajina S, Bridge H. Subcortical pathways to extrastriate visual cortex underlie residual vision following bilateral damage to V1. Neuropsychologia. 2018;: pubmed publisher
    ..Performance was compared to the neural activation in motion area hMT+ measured using functional magnetic resonance imaging...
  48. Zheng Y, Wang Q, Li B, Lin L, Tundis R, Loizzo M, et al. Characterization and Prebiotic Effect of the Resistant Starch from Purple Sweet Potato. Molecules. 2016;21: pubmed publisher
    ..The effects of heat-moisture treatment (HMT) and enzyme debranching combined heat-moisture treatment (EHMT) on the morphological, crystallinity and thermal ..
  49. Liu Q, Liu X, Shi C, Zhang Y, Feng X, Cheng M, et al. A copper-based layered coordination polymer: synthesis, magnetic properties and electrochemical performance in supercapacitors. Dalton Trans. 2015;44:19175-84 pubmed publisher
    A copper-based layered coordination polymer ([Cu(hmt)(tfbdc)(H2O)]; hmt = hexamethylenetetramine, tfbdc = 2,3,5,6-tetrafluoroterephthalate; Cu-LCP) has been synthesized, and it has been structurally and magnetically characterized...
  50. Larcombe S, Kennard C, Bridge H. Increase in MST activity correlates with visual motion learning: A functional MRI study of perceptual learning. Hum Brain Mapp. 2017;: pubmed publisher
    ..MST is the anterior portion of the human motion complex (hMT+)...
  51. Barnes W, Grinde E, Crawford D, Herrick Davis K, Hough L. Characterization of a new mRNA species from the human histamine N-methyltransferase gene. Genomics. 2004;83:168-71 pubmed
    ..These studies show that HNMT-S is a new mRNA species and putative protein product from HNMT. The physiological role of HNMT-S remains to be investigated. ..
  52. Wojtala M, Macierzyńska Piotrowska E, Rybaczek D, Pirola L, Balcerczyk A. Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacol Res. 2018;128:252-263 pubmed publisher
    ..The euchromatic G9a histone methyltransferase (G9a HMT) is a key enzyme catalyzing histone H3 methylation on lysines 9 and 27, and its dysregulation has been linked to ..
  53. Attaya M, Jameson S, Martinez C, Hermel E, Aldrich C, Forman J, et al. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature. 1992;355:647-9 pubmed
    ..Processing defects for classical (H-2 K and D) and non-classical (Qa1 and HMT) class I molecules are corrected by Ham-2...
  54. Hailong C, Cao H, Mei Q, Zhang L, Xu J. C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population. Clin Chim Acta. 2008;389:51-4 pubmed
    ..The HNMT T314 allele frequency is lower in Chinese population than in American Caucasians. No association can be found in the involvement of HNMT C314T polymorphism in the susceptibility to duodenal ulcer. ..
  55. Maeda M, Ebara N, Tani M, Vavricka C, Kimura Y. Occurrence of complex type free N-glycans with a single GlcNAc residue at the reducing termini in the fresh-water plant, Egeria densa. Glycoconj J. 2017;34:229-240 pubmed publisher
    ..a novel biosynthetic mechanism responsible for the production of these unique GN1-FNGs, in which high-mannose type (HMT)-GN1-FNGs produced in the cytosol from misfolded glycoproteins by ENGase are transported back into the endoplasmic ..
  56. Ferreira M, Pires Luís A, Vieira Coimbra M, Costa Pinheiro P, Antunes L, Dias P, et al. SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization. Epigenetics. 2017;: pubmed publisher
    ..We found that SETDB2 and RIOX2 (encoding for an HMT and an HDM, respectively) expression levels was significantly altered in RCTs; these genes were further selected ..
  57. Chen Y, Yang Q, Xu X, Qi L, Dong Z, Luo Z, et al. Structural changes of waxy and normal maize starches modified by heat moisture treatment and their relationship with starch digestibility. Carbohydr Polym. 2017;177:232-240 pubmed publisher
    ..present study, the variations in structure of waxy and normal maize starches modified by heat-moisture treatment (HMT) for different treating time (3h and 9h) were investigated. HMT caused the destruction of starch granules...
  58. Rutherford K, Parson W, Daggett V. The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics. Biochemistry. 2008;47:893-901 pubmed
    ..The simulations also show that the hydrophobic histamine-binding domain in both proteins undergoes a large-scale breathing motion that exposes key catalytic residues and lowers the hydrophobicity of the substrate-binding site. ..
  59. Adawiyah D, Akuzawa S, Sasaki T, Kohyama K. A comparison of the effects of heat moisture treatment (HMT) on rheological properties and amylopectin structure in sago (Metroxylon sago) and arenga (Arenga pinnata) starches. J Food Sci Technol. 2017;54:3404-3410 pubmed publisher
    The objective of this study was to study and compare the impact of HMT on rheology and textural properties observed between sago and arenga starces, and then related to structural change of amylopectin...
  60. Schaeffner L, Welchman A. Mapping the visual brain areas susceptible to phosphene induction through brain stimulation. Exp Brain Res. 2017;235:205-217 pubmed publisher
    ..However, phosphenes are less likely in more lateral locations (hMT+/V5 and LOC)...
  61. Nguyen H, Dong J, Panchakshari R, Kumar V, Alt F, Bories J. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017;114:E10560-E10567 pubmed publisher
    ..Here, we used gene targeted inactivation of histone methyltransferase (HMT) multiple myeloma SET domain (MMSET) in mouse B cells and the CH12F3 cell line to explore its role in CSR...
  62. Szczepankiewicz A, Breborowicz A, Sobkowiak P, Popiel A. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study. Clin Mol Allergy. 2010;8:14 pubmed publisher
    ..Our results indicate modifying influence of histamine N-methyltransferase functional polymorphism on the risk of asthma. The other HNMT polymorphisms and ABP1 functional polymorphism seem unlikely to affect the risk of asthma. ..
  63. Nakamura S, Okumura H, Sugawara M, Noro W, Homma N, Ohtsubo K. Effects of different heat-moisture treatments on the physicochemical properties of brown rice flour. Biosci Biotechnol Biochem. 2017;:1-16 pubmed publisher
    We evaluated the effect of heat-moisture treatment (HMT) on the main chemical components, physical properties, and enzyme activities of two types of brown rice flour: high-amylose Koshinokaori and normal-quality Koshiibuki...
  64. Jimenez Jimenez F, Garcia Martin E, Alonso Navarro H, Martinez C, Zurdo M, Turpín Fenoll L, et al. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome. J Neural Transm (Vienna). 2017;124:285-291 pubmed publisher
    ..RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS. ..
  65. Sooksa nguan T, Yakubov B, Kozlovskyy V, Barkume C, Howe K, Thannhauser T, et al. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. J Biol Chem. 2009;284:354-62 pubmed publisher
    Half-molecule ATP-binding cassette transporters of the HMT-1 (heavy metal tolerance factor 1) subfamily are required for Cd2+ tolerance in Schizosaccharomyces pombe, Caenorhabditis elegans, and Chlamydomonas reinhardtii...
  66. Garcia Martin E, Martinez C, Serrador M, Alonso Navarro H, Navacerrada F, Agundez J, et al. Histamine-N-methyl transferase polymorphism and risk for migraine. Headache. 2008;48:1343-8 pubmed publisher
    ..The results of the present study suggest that HNMT polymorphism in not related with the risk for migraine. ..
  67. Garcia Martin E, Martinez C, Benito Leon J, Calleja P, Diaz Sanchez M, Pisa D, et al. Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis. Eur J Neurol. 2010;17:335-8 pubmed publisher
    ..The HNMT polymorphism is not related with the risk for MS. ..
  68. Heidari A, Tongsook C, Najafipour R, Musante L, Vasli N, Garshasbi M, et al. Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability. Hum Mol Genet. 2015;24:5697-710 pubmed publisher
    ..Leu208Pro results in reduced protein stability, resulting in decreased HA inactivation. Our results highlight the importance of inclusion of HNMT for genetic testing of individuals presenting with intellectual disability. ..
  69. Haney N, Nguyen H, Honda M, Abdel Mageed A, Hellstrom W. Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions. Sex Med Rev. 2018;6:234-241 pubmed publisher
    ..Haney NM, Nguyen HMT, Honda M, et al...
  70. Saha A, Sinhamahapatra A, Kang T, Ghosh S, Yu J, Panda A. Hydrogenated MoS2 QD-TiO2 heterojunction mediated efficient solar hydrogen production. Nanoscale. 2017;9:17029-17036 pubmed publisher
    Herein, we report the development of a hydrogenated MoS2 QD-TiO2 (HMT) heterojunction as an efficient photocatalytic system via a one-pot hydrothermal reaction followed by hydrogenation...
  71. Aksoy S, Raftogianis R, Weinshilboum R. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. Biochem Biophys Res Commun. 1996;219:548-54 pubmed
    ..HNMT mapped to human chromosome 2. Structural characterization of the gene for HNMT will make it possible to study molecular genetic mechanisms involved in the regulation of this important enzyme in humans. ..
  72. Kim Y, Byeon J, Kim S, Lee C, Jung E, Chae W, et al. Simultaneous determination of tolterodine and its two metabolites, 5-hydroxymethyltolterodine and N-dealkyltolterodine in human plasma using LC-MS/MS and its application to a pharmacokinetic study. Arch Pharm Res. 2017;40:1287-1295 pubmed publisher
    ..LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma...
  73. Petersen J, Drasche A, Raithel M, Schwelberger H. Analysis of genetic polymorphisms of enzymes involved in histamine metabolism. Inflamm Res. 2003;52 Suppl 1:S69-70 pubmed
  74. Hon Y, Jusko W, Zhou H, Chen G, Guo D, Zhou G, et al. Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase C314T genotypes : a pilot study. Mol Diagn Ther. 2006;10:109-14 pubmed
    ..Wide variability of plasma and whole-blood histamine levels was observed in subjects with different HNMT C314T genotypes. Endogenous levels of histamine are likely to be affected by various genes and polymorphisms. ..
  75. Li T, Hodgson J, Petruk S, Mazo A, Brock H. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Epigenetics Chromatin. 2017;10:43 pubmed publisher
    ..We show that in vitro, Asx binds directly to the SET domains of the histone methyltransferases (HMT) enhancer of zeste [E(z)] (H3K27me3) and Trx (H3K4me3) through a bipartite interaction site separated by 846 amino ..
  76. Nguyen H, Anaissie J, DeLay K, Yafi F, Sikka S, Hellstrom W. Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute-Phase Peyronie's Disease. J Sex Med. 2017;14:1220-1225 pubmed publisher
    ..Nguyen HMT, Anaissie J, DeLay KJ, et al...
  77. Bender L, Cao R, Zhang Y, Strome S. The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans. Curr Biol. 2004;14:1639-43 pubmed
    ..Another H3-K27 HMT functions in adult somatic cells, oocytes, and the PGCs of embryos...
  78. Choi J, Kim S, Suh C, Nahm D, Park H. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. J Korean Med Sci. 2005;20:367-72 pubmed
    ..05, respectively). These results suggest that the polymorphisms of FCER1B and the three histamine-related genes may not contribute to the development of AIU phenotype in the Korean population. ..
  79. Trung P, Ngoc L, Hoa P, Tien N, Hung P. Impact of heat-moisture and annealing treatments on physicochemical properties and digestibility of starches from different colored sweet potato varieties. Int J Biol Macromol. 2017;105:1071-1078 pubmed publisher
    ..and digestibility of starches isolated from colored sweet potato varieties under heat-moisture treatment (HMT) or annealing treatment (ANN)...
  80. Solismaa A, Kampman O, Lyytikäinen L, Seppälä N, Viikki M, Mononen N, et al. Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients. Eur Neuropsychopharmacol. 2017;27:442-449 pubmed publisher
    ..22). Polymorphisms in genes encoding histamine receptors or enzymes related to histamine metabolism may explain individual variation in sedative effects experienced during clozapine treatment. ..
  81. Kim S, Selote D, Vatamaniuk O. The N-terminal extension domain of the C. elegans half-molecule ABC transporter, HMT-1, is required for protein-protein interactions and function. PLoS ONE. 2010;5:e12938 pubmed publisher
    Members of the HMT-1 (heavy metal tolerance factor 1) subfamily of the ATP-binding cassette (ABC) transporter superfamily detoxify heavy metals and have unique topology: they are half-molecule ABC transporters that, in addition to a ..
  82. Olsen J, Wong L, Deimling S, Miles A, Guo H, Li Y, et al. G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis. Stem Cell Reports. 2016;7:454-470 pubmed publisher
    ..These cell-fate transitions typically involve dynamic regulation of gene expression by histone methyltransferase (HMT) complexes...
  83. Jimenez Jimenez F, Alonso Navarro H, Garcia Martin E, Agundez J. Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2016;95:e4147 pubmed publisher
    ..61 (0.46-0.81) for the total group, and 0.63 (0.45-0.88) for Caucasian patients. The present meta-analysis confirms published evidence suggesting that the HNMT rs11558538 minor allele is related to a reduced risk of developing PD. ..
  84. Wang H, Liu Y, Chen L, Li X, Wang J, Xie F. Insights into the multi-scale structure and digestibility of heat-moisture treated rice starch. Food Chem. 2018;242:323-329 pubmed publisher
    The digestibility and structural changes of rice starch induced by heat-moisture treatment (HMT) were investigated, and the relationships among the moisture content-starch structure-starch digestibility were revealed...
  85. Naganuma F, Nakamura T, Yoshikawa T, Iida T, Miura Y, Kárpáti A, et al. Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Sci Rep. 2017;7:15899 pubmed publisher
    ..These observations inform the physiological roles of HNMT. ..
  86. Park E, Kim M, Cho M, Lee J, Kim J. Production of starch nanoparticles using normal maize starch via heat-moisture treatment under mildly acidic conditions and homogenization. Carbohydr Polym. 2016;151:274-282 pubmed publisher
    Normal maize starch was subjected to heat-moisture treatment (HMT) under mildly acidic conditions (0.000, 0.050, or 0.075M H2SO4) for various treatment times (3, 5, or 8h) followed by homogenization up to 60min to prepare nanoparticles...
  87. Cechinel L, Basso C, Bertoldi K, Schallenberger B, de Meireles L, Siqueira I. Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats. Behav Brain Res. 2016;313:82-87 pubmed publisher
    ..and daily exercise, to modulate epigenetic marks, namely global H4 acetylation, histone methyltransferase activity (HMT H3K27) and levels of DNA methytransferase (DNMT1 and DNMT3b) in prefrontal cortices from 3 and 21-months aged ..
  88. He G, Cai W, Zhang J, Ma C, Yan F, Lu J, et al. Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure. Biomed Res Int. 2016;2016:1208476 pubmed publisher