Gene Symbol: HIST4H4
Description: histone cluster 4 H4
Alias: H4/p, histone H4, histone 4, H4
Species: human
Products:     HIST4H4

Top Publications

  1. Zhang Y, Sun Z, Iratni R, Erdjument Bromage H, Tempst P, Hampsey M, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998;1:1021-31 pubmed
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms. ..
  2. Kanno T, Kanno Y, Siegel R, Jang M, Lenardo M, Ozato K. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell. 2004;13:33-43 pubmed
    ..The bromodomain protein Brd2 selectively interacted with acetylated lysine 12 on histone H4, whereas TAF(II)250 and PCAF recognized H3 and other acetylated histones, indicating fine specificity of histone ..
  3. Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, et al. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. Int J Cancer. 2004;110:362-7 pubmed
    ..The expression levels of MTA1 protein and the acetylation levels of histone H4 were examined in 70 cases of surgically resected esophageal squamous cell carcinomas, using immunohistochemistry...
  4. Murzina N, Pei X, Zhang W, Sparkes M, Vicente Garcia J, Pratap J, et al. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008;16:1077-85 pubmed publisher
    ..We report here the crystal structure of human RbAp46 bound to histone H4. RbAp46 folds into a seven-bladed beta propeller structure and binds histone H4 in a groove formed between an N-..
  5. Shogren Knaak M, Ishii H, Sun J, Pazin M, Davie J, Peterson C. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science. 2006;311:844-7 pubmed
    Acetylation of histone H4 on lysine 16 (H4-K16Ac) is a prevalent and reversible posttranslational chromatin modification in eukaryotes...
  6. Jha S, Shibata E, Dutta A. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol. 2008;28:2690-700 pubmed publisher
    ..Rvb1 is required for the histone acetyltransferase (HAT) activity of the Tip60 complex, and histone H4 acetylation is required prior to the dephosphorylation of phospho-H2AX...
  7. Mallette F, Mattiroli F, Cui G, Young L, Hendzel M, Mer G, et al. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 2012;31:1865-78 pubmed publisher
    ..of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20...
  8. Fraga M, Ballestar E, Villar Garea A, Boix Chornet M, Espada J, Schotta G, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005;37:391-400 pubmed
    ..We characterized post-translational modifications to histone H4 in a comprehensive panel of normal tissues, cancer cell lines and primary tumors...
  9. Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, et al. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev. 2011;25:901-6 pubmed publisher
    ..The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer...

More Information

Publications134 found, 100 shown here

  1. Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher
    ..were assessed by immuno-fluorescence for FITC-tagged phospho-H3 as well as video-microscopy for GFP-tagged histone H4. Annexin V/propidium iodide staining, caspase3/PARP cleavage and colony formation assays were done to ..
  2. Lin C, Lin W, Hou W, Hsiao L, Yang C. Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L211-25 pubmed publisher
    ..ET-1 also stimulated phosphorylation of Src, EGFR, PDGFR, AKT, p42/p44 MAPK, and Elk-1 and acetylation of histone H4 on HTSMCs. Immunoprecipitation assay showed the association between Elk-1 and p300 in the nucleus...
  3. Kasai K, Nishiyama N, Izumi Y, Otsuka S, Ishihara A, Yamauchi K. Exposure to 3,3',5-triiodothyronine affects histone and RNA polymerase II modifications, but not DNA methylation status, in the regulatory region of the Xenopus laevis thyroid hormone receptor βΑ gene. Biochem Biophys Res Commun. 2015;467:33-8 pubmed publisher
    ..Exposure to T3 increased the amount of the thrb transcript, in parallel with enhanced histone H4 acetylation and RNAPII recruitment, and probably phosphorylation of RNAPII at serine 5, in the 5' regulatory and ..
  4. Narayan V, Ravindra K, Liao C, Kaushal N, Carlson B, Prabhu K. Epigenetic regulation of inflammatory gene expression in macrophages by selenium. J Nutr Biochem. 2015;26:138-45 pubmed publisher
    ..Our results indicated that selenium supplementation, as selenite, decreased acetylation of histone H4 at K12 and K16 in COX-2 and TNFα promoters, and of the p65 subunit of the redox sensitive transcription ..
  5. Bai A, Wu W, Xu L, Wong S, Go M, Chan A, et al. Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10. J Crohns Colitis. 2016;10:726-34 pubmed publisher
    ..Pharmacological inhibition of KAT2B by anacardic acid in NCM460 cells reduced the levels of histone H4 lysine 5 acetylation [H4K5ac] and interleukin-10 [IL-10] in a dose-dependent manner...
  6. Zapletal O, Tylichová Z, Neca J, Kohoutek J, Machala M, Milcova A, et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. Arch Toxicol. 2017;91:2135-2150 pubmed publisher
    ..NaBt-induced acetylation of histone H3 (at Lys14) and histone H4 (at Lys16), two histone modifications modulated during activation of CYP1A1 transcription, and it reduced ..
  7. Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, et al. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014;289:34743-67 pubmed publisher
    ..The chromatin immunoprecipitation analysis revealed that hyperacetylation of histone H4 by NaBu is associated with the PKCδ promoter...
  8. Suzuki T, Muramatsu T, Morioka K, Goda T, Mochizuki K. ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model. Nutrition. 2015;31:877-83 pubmed publisher
    ..compared with the livers of control rats, levels of mono-methylated histone H3 lysine (K) 4 and acetylated histone H4 were higher in the promoter/enhancer region of the Fasn gene in the livers of SHR/NDmc-cp rats...
  9. Choi S, Ryu Y, Kee H, Cho S, Kim G, Cho J, et al. Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes. Vascul Pharmacol. 2015;72:130-40 pubmed publisher
    ..The chromatin immunoprecipitation assay revealed that the HDAC6 inhibitor suppressed TGF-β-induced acetylated histone H4 or phospho-Smad2/3 to Smad3 binding elements in the fibrosis-associated gene promoters including collagen type I...
  10. Coscas R, Dupont S, Mussot S, Louedec L, Etienne H, Morvan M, et al. Exploring antibody-dependent adaptive immunity against aortic extracellular matrix components in experimental aortic aneurysms. J Vasc Surg. 2018;68:60S-71S.e3 pubmed publisher
    ..Immunofluorescence analysis demonstrated that myeloperoxidase co-localized with tissue-free DNA and histone H4, highlighting local neutrophil activation and formation of neutrophil extracellular traps...
  11. Zhang X, Zhou D, Strakovsky R, Zhang Y, Pan Y. Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model. Am J Physiol Gastrointest Liver Physiol. 2012;302:G558-64 pubmed publisher
    ..In OP rats, the increase of p16(INK4a) was associated with the higher acetylation levels of histone H4 at the p16(INK4a) promoter and coding region and lower methylation level of histone H3 lysine-27 in the p16(..
  12. Lee T, Lee T, Lin Y, Kao Y, Chen Y. Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes. J Biomed Sci. 2018;25:42 pubmed publisher
    ..The ChIP analysis demonstrated a significant decrease in acetyl-histone H4, which is associated with an increase in HDAC3 in the FGFR1 promoter...
  13. Jayanthi S, McCoy M, Chen B, Britt J, Kourrich S, Yau H, et al. Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biol Psychiatry. 2014;76:47-56 pubmed publisher
    ..Chromatin immunoprecipitation-polymerase chain reaction revealed that METH decreased enrichment of acetylated histone H4 on GluA1, GluA2, and GluN1 promoters...
  14. Kato Y, Egusa C, Maeda T, Tsuboi R. Combination of retinoid and histone deacetylase inhibitor produced an anti-tumor effect in cutaneous T-cell lymphoma by restoring tumor suppressor gene, retinoic acid receptorβ2, via histone acetylation. J Dermatol Sci. 2016;81:17-25 pubmed publisher
    ..In the combination treatment, the histone H4 acetylation level at lysine 12 and 16 in the promoter region increased after restoration of RARβ2 expression ..
  15. Eriksson M, Hååg P, Brzozowska B, Lipka M, Lisowska H, Lewensohn R, et al. Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment. Int J Radiat Oncol Biol Phys. 2018;100:174-187 pubmed publisher
    ..and trichostatin A increased the euchromatin markers acetylated lysine 9/14 of histone H3 and lysine 8 of histone H4, and HDACi pretreatment increased the phosphorylation of the DNA damage response proteins ataxia telangiectasia ..
  16. Vyas F, Hargreaves A, Bonner P, Boocock D, Coveney C, Dickenson J. A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival. Biochem Pharmacol. 2016;107:41-58 pubmed publisher
    ..revealed TG2-mediated biotin-X-cadaverine incorporation into proteins and proteomic analysis identified known (Histone H4) and novel (Hexokinase 1) protein substrates for TG2...
  17. Simoneau A, Delgoshaie N, Celic I, Dai J, Abshiru N, Costantino S, et al. Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage. Genetics. 2015;200:185-205 pubmed publisher
    ..We found that reducing the levels of histone H4 lysine 16 acetylation or H3 lysine 79 methylation partially suppresses these sensitivities and reduces ..
  18. McCoy C, Reaves B, Giguere S, Coates R, Rada B, Wolstenholme A. Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release. PLoS Negl Trop Dis. 2017;11:e0005279 pubmed publisher
    ..aggregates labelled with DAPI and antibodies to human neutrophil elastase, myeloperoxidase and citrullinated histone H4. A fluorescent, extracellular DNA release assay was used to quantify and observe Mf induced NETosis over time...
  19. Tian Y, Wong V, Wong G, Yang W, Sun H, Shen J, et al. Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma. Cancer Res. 2015;75:4803-16 pubmed publisher
    ..HDAC8 physically interacted with the chromatin modifier EZH2 to concordantly repress Wnt antagonists via histone H4 deacetylation and H3 lysine 27 trimethylation...
  20. Hsu P, Wu C, Chang J, Lin W. Leptin Promotes cPLA₂ Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade. Int J Mol Sci. 2015;16:27640-58 pubmed publisher
    ..Furthermore, p300 phosphorylation and histone H4 acetylation were reduced by blockage of OB-R, p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-κB in leptin-stimulated ..
  21. Lorenz V, Milesi M, Schimpf M, Luque E, Varayoud J. Epigenetic disruption of estrogen receptor alpha is induced by a glyphosate-based herbicide in the preimplantation uterus of rats. Mol Cell Endocrinol. 2019;480:133-141 pubmed publisher
    ..A decrease in DNA methylation was observed in one of the three sites evaluated in the O promoter. Moreover, histone H4 acetylation and histone H3 lysine 9 trimethylation (H3K9me3) were enriched in the O promoter in GBH-exposed rats,..
  22. Huang Z, Li D, Ou Yang H, Liu C, Liu X, Ma C, et al. Cerebrospinal Fluid Oxaliplatin Contributes to the Acute Pain Induced by Systemic Administration of Oxaliplatin. Anesthesiology. 2016;124:1109-21 pubmed publisher
    ..The authors further found that oxaliplatin significantly increased the nuclear factor-κB p65 binding and histone H4 acetylation in cx3cl1 promoter region...
  23. Chen K, Zhang S, Ke X, Qi H, Shao J, Shen J. Biphasic reduction of histone H3 phosphorylation in response to N-nitroso compounds induced DNA damage. Biochim Biophys Acta. 2016;1860:1836-44 pubmed publisher
    ..reduction of histone H3 phosphorylation at serine 10 (H3S10ph) and serine 28 (H3S28ph), and a rapid decrease of histone H4 acetylation upon MNNG and MNU exposure...
  24. Gupta A, Zhu L, Tripathi J, Kucharski M, Patra A, Bozdech Z. Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum. Epigenetics Chromatin. 2017;10:40 pubmed publisher
    ..falciparum. Using a dominant-negative transgenic approach, we showed that acetylations of histone H4 play a direct role in transcription...
  25. Marin R, Cortez D, Lamanna F, Pradeepa M, Leushkin E, Julien P, et al. Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage. Genome Res. 2017;: pubmed publisher
    ..only in males and is mediated by a male-specific chromatin machinery that leads to global hyperacetylation of histone H4 at lysine 16 specifically on the X Chromosome...
  26. Young C, Rothfuss H, Gard P, Muth A, Thompson P, Ashley R, et al. Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells. Reproduction. 2017;153:1-10 pubmed publisher
    ..epithelial (OLE) cell line shows that histone H3 arginine residues 2, 8, 17 and 26 are citrullinated, but histone H4 arginine 3 is not...
  27. Li L, Thorsten S, Kyoon S, Al Rasheid Khaled A, Al Khedhairy Bdulaziz A, Song W. Protocruzia, a highly ambiguous ciliate (Protozoa; Ciliophora): very likely an ancestral form for Heterotrichea, Colpodea or Spirotrichea? With reevaluation of its evolutionary position based on multigene analyses. Sci China Life Sci. 2010;53:131-138 pubmed publisher
    ..using the small subunit rRNA (SSU rRNA) gene, internal transcribed spacer 2 (ITS2) and a protein coding gene (histone H4)...
  28. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  29. Kim S, Kang J, Kim C, Ihm S, Choi M, Yoo H, et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. Endocrine. 2016;51:274-82 pubmed publisher
    ..histone H3, acetyl. histone H4, cleaved PARP, and cleaved caspase-3 were enhanced...
  30. Sekirnik Née Measures A, Hewings D, Theodoulou N, Jursins L, Lewendon K, Jennings L, et al. Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3. Angew Chem Int Ed Engl. 2016;55:8353-7 pubmed publisher
    ..Three of these amino acids were incorporated into a histone H4-mimicking peptide and their affinity for BRD4(1) was assessed...
  31. Elsner V, Basso C, Bertoldi K, de Meireles L, Cechinel L, Siqueira I. Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development. J Physiol Sci. 2017;67:387-394 pubmed publisher
    ..group, given that exercised rats showed decreased HDAC activity 1 and 18 h after training, without effect on histone H4 acetylation levels...
  32. Chua M, Arnold M, Xu W, Lancelot J, Lamotte S, Späth G, et al. Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. Int J Parasitol Drugs Drug Resist. 2017;7:42-50 pubmed publisher
    ..Each of the HDAC inhibitor drugs caused hyperacetylation of P. knowlesi histone H4. None of the drugs was active against Leishmania amastigote or promastigote parasites (IC50 > 20..
  33. Valiuliene G, Stirblyte I, Jasnauskaitė M, Borutinskaite V, Navakauskiene R. Anti-leukemic effects of HDACi Belinostat and HMTi 3-Deazaneplanocin A on human acute promyelocytic leukemia cells. Eur J Pharmacol. 2017;799:143-153 pubmed publisher
    ..RA caused a depletion in HDAC1 and HDAC2 protein levels, HDAC2 gene expression and increased hyperacetylation of histone H4 in both leukemia cell lines...
  34. Zhang Y, Yan J, Yao T. Discovery of a fluorescent probe with HDAC6 selective inhibition. Eur J Med Chem. 2017;141:596-602 pubmed publisher
    ..HDAC1-11) reveals that 6b is a HDAC6 selective inhibitor, which can induce hyperacetylation of tubulin but not histone H4. Importantly, fluorescent and immunofluorescent analyses of cells treated with the proteasome inhibitor MG132 ..
  35. Glover Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher R, et al. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol. 2009;29:5455-64 pubmed publisher
    ..A role of Cdk7 in regulating elongation is further suggested by enhanced histone H4 acetylation and diminished histone H4 trimethylation on lysine 36-two marks of elongation-within genes when the ..
  36. Yamamura Y, Motegi K, Kani K, Takano H, Momota Y, Aota K, et al. TNF-? inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. J Cell Mol Med. 2012;16:1766-75 pubmed publisher
    ..interestingly, chromatin immunoprecipitation analysis demonstrated a remarkable decrease in levels of acetylated histone H4 associated with the AQP5 gene promoter after treatment with TNF-? in NS-SV-AC cells...
  37. Duskova E, Hnilicová J, Stanek D. CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation. RNA Biol. 2014;11:865-74 pubmed publisher
    ..Next we showed that p300 controls histone H4 acetylation along the FN1 gene...
  38. Peleg S, Feller C, Forne I, Schiller E, Sévin D, Schauer T, et al. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep. 2016;17:455-69 pubmed publisher
    ..we decreased the activity of the acetyl-CoA-synthesizing enzyme ATP citrate lyase (ATPCL) or the levels of the histone H4 K12-specific acetyltransferase Chameau...
  39. Milite C, Feoli A, Viviano M, Rescigno D, Mai A, Castellano S, et al. Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors. ChemMedChem. 2016;11:1680-5 pubmed publisher
    SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo...
  40. Mahajan K, Malla P, Lawrence H, Chen Z, Kumar Sinha C, Malik R, et al. ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer. Cancer Cell. 2017;31:790-803.e8 pubmed publisher
    ..Here, we report that the tyrosine kinase ACK1 (TNK2) phosphorylates histone H4 at tyrosine 88 upstream of the AR transcription start site...
  41. Schnekenburger M, Mathieu V, Lefranc F, Jang J, Masi M, Kijjoa A, et al. The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition. Molecules. 2018;23: pubmed publisher
    ..Accordingly, this sequiterpene alkaloid induces histone H4 and α-tubulin acetylation in various cancer cell models in which it induces strong cytostatic effects without ..
  42. Zhang H, Han J, Kang B, Burgess R, Zhang Z. Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4. J Biol Chem. 2012;287:6573-81 pubmed publisher
    ..1) and H3 variant (H3.3) differ by five amino acids and are assembled, along with histone H4, into nucleosomes via distinct nucleosome assembly pathways. H3...
  43. Sidhu K, Kumar V. c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication. Biochim Biophys Acta. 2015;1849:1319-28 pubmed publisher
    ..by acetylated histone H3 orchestrated by histone acetyl transferase GCN5 and followed by HBO1 mediated histone H4 acetylation...
  44. Matheis N, Lantz M, Grus F, Ponto K, Wolters D, Brorson H, et al. Proteomics of Orbital Tissue in Thyroid-Associated Orbitopathy. J Clin Endocrinol Metab. 2015;100:E1523-30 pubmed publisher
    ..3-fold), annexin A2 and cavin (both 3-fold), protein pointing to cell proliferation histone H4 (2.8-fold), and ADAM metallopeptidase with thrombospondin type 1 motif 14 (2.7-fold)...
  45. Tsuchiya Y, Naito T, Tenno M, Maruyama M, Koseki H, Taniuchi I, et al. ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells. J Leukoc Biol. 2016;100:327-38 pubmed publisher
    ..of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20...
  46. Asahina Y, Kawakami T, Hojo H. One-pot native chemical ligation by combination of two orthogonal thioester precursors. Chem Commun (Camb). 2017;53:2114-2117 pubmed publisher
    ..Combination of the two precursors facilitated the one-pot operation and yielded the entire polypeptide. The usefulness of this method was successfully demonstrated by the total synthesis of histone H4.
  47. Dhall A, Weller C, Chu A, Shelton P, Chatterjee C. Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex. ACS Chem Biol. 2017;12:2275-2280 pubmed publisher
    ..We discovered that nucleosomes containing sumoylated histone H4 (suH4), a modification associated with gene repression, stimulate LSD1 activity by a mechanism dependent upon ..
  48. Yang X, Ogryzko V, Nishikawa J, Howard B, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996;382:319-24 pubmed
    ..Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase. ..
  49. Ghule P, Xie R, Colby J, Jones S, Lian J, Wijnen A, et al. p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency. Cell Cycle. 2015;14:2501-8 pubmed publisher
    Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes...
  50. Gao Y, Zhao Y, Zhang J, Lu Y, Liu X, Geng P, et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci Rep. 2016;6:19874 pubmed publisher
    ..PRMT1 impacted EMT process and cellular senescence by mediating the asymmetric dimethylation of arginine 3 of histone H4 (H4R3me2as) at the ZEB1 promoter to activate its transcription, indicating the essential roles of this ..
  51. Li X, Gou C, Yao L, Lei Z, Gu T, Ren F, et al. Patients with HBV-related acute-on-chronic liver failure have increased concentrations of extracellular histones aggravating cellular damage and systemic inflammation. J Viral Hepat. 2017;24:59-67 pubmed publisher
    ..Plasma histone H4 levels, cytokine profile and clinical data were obtained...
  52. Xu T, Zhang X, Ou Yang H, Li Z, Liu C, Huang Z, et al. Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain. Pain. 2017;158:637-648 pubmed publisher
    ..the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the acetylation of histone H4 in the CXCL12-expressing neurons...
  53. Wei D, Li A, Zhao C, Wang H, Mei C, Khan R, et al. Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2. Int J Mol Sci. 2018;19: pubmed publisher
    ..ChIP) assay, in combination with site-directed mutation and siRNA interference, demonstrated that histone H4 and E2F2 bind to the -216/-28 region and play important roles in SIX1 methylation regulation during ..
  54. Quivy J, Roche D, Kirschner D, Tagami H, Nakatani Y, Almouzni G. A CAF-1 dependent pool of HP1 during heterochromatin duplication. EMBO J. 2004;23:3516-26 pubmed
  55. Fidlerová H, Kalinova J, Blechová M, Velek J, Raska I. A new epigenetic marker: the replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail. J Struct Biol. 2009;167:76-82 pubmed publisher
    ..Here we identified epiC as a dual post-translational modification on the same histone H4 tail, which was immunodetected for the first time...
  56. Tong Q, Cui G, Botuyan M, Rothbart S, Hayashi R, Musselman C, et al. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure. 2015;23:312-21 pubmed publisher
  57. Ramos T, Nunes V, Nardelli S, Dos Santos Pascoalino B, Moretti N, Rocha A, et al. Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi. Mol Biochem Parasitol. 2015;204:1-10 pubmed publisher
    The histone H4 from Trypanosomatids diverged from other eukaryotes in the N-terminus, a region that undergoes post-translation modifications involved in the control of gene expression, DNA replication, and chromatin assembly...
  58. Bailey A, Panchenko T, Shabanowitz J, Lehman S, Bai D, Hunt D, et al. Identification of the Post-translational Modifications Present in Centromeric Chromatin. Mol Cell Proteomics. 2016;15:918-31 pubmed publisher
    ..We report a surprisingly uniform pattern of primarily monomethylation on lysine 20 of histone H4 present in short polynucleosomes mixtures of CENP-A and H3 nucleosomes isolated from functional centromeres...
  59. Chen D, Kluz T, Fang L, Zhang X, Sun H, Jin C, et al. Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1. PLoS ONE. 2016;11:e0157317 pubmed publisher
    ..We propose that Cr(VI) induces Nupr1 and rapidly perturbs gene expression by downregulating H4K16 acetylation, thereby contributing to Cr(VI)-induced carcinogenesis. ..
  60. Brewster R, Gavins G, Günthardt B, Farr S, Webb K, Voigt P, et al. Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins. Chem Commun (Camb). 2016;52:12230-12232 pubmed
    ..Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.
  61. Jin L, Zhu H, Guo Q, Li X, Zhang Y, Cui C, et al. Effect of histone acetylation modification with MGCD0103, a histone deacetylase inhibitor, on nuclear reprogramming and the developmental competence of porcine somatic cell nuclear transfer embryos. Theriogenology. 2017;87:298-305 pubmed publisher
    ..somatic cell nuclear transferred (SCNT) embryos and expression in acetylation of the histone H3 lysine 9 and histone H4 lysine 12...
  62. Motheo T, Arnold D, Padilha Nakaghi L, Pires Buttler E, Alves A, Apparicio M, et al. Changes in acetylation of lysine 5 on histone H4 in canine oocytes following in vitro maturation. Reprod Domest Anim. 2017;52 Suppl 2:103-107 pubmed publisher
    ..This study aimed to evaluate the post-translational histone H4 acetylation at lysine 5 (H4K5) in immature and post-IVM canine oocytes...
  63. Wang D, Liu C, Li Z, Wang Y, Wang W, Wu X, et al. Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells. J Cell Biochem. 2017;118:4460-4467 pubmed publisher
    ..Especially, histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (..
  64. Androutsopoulos V, Spandidos D. Antiproliferative effects of TSA, PXD?101 and MS?275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. Oncol Rep. 2017;38:3412-3418 pubmed publisher
    ..to acetylated tubulin, western blot analysis and flow cytometry indicated that the induction of acetylated histone H4 was considerably smaller...
  65. Paradowska A, Miller D, Spiess A, Vieweg M, Cerna M, Dvorakova Hortova K, et al. Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development. Epigenetics. 2012;7:1057-70 pubmed
    ..b>Histone H4 acetylated at lysine 12 (H4K12ac) is localized in the post-acrosomal region, while protamine-1 is present within ..
  66. de Moura A, da Silva I, Reinaldo G, Dani C, Elsner V, Giovenardi M. Global Histone H4 Acetylation in the Olfactory Bulb of Lactating Rats with Different Patterns of Maternal Behavior. Cell Mol Neurobiol. 2016;36:1209-13 pubmed publisher
    ..Afterward, the modulation of histone acetylation levels could exert a pivotal role through molecular mechanisms involved in the different patterns of maternal behavior. ..
  67. Hu H, Chen E, Li Y, Zhu X, Zhang T, Zhu X. Effects of Arsenic Trioxide on INF-gamma Gene Expression in MRL/lpr Mice and Human Lupus. Biol Trace Elem Res. 2018;184:391-397 pubmed publisher
    ..both splenocytes of MRL/lpr mice and PBMCs of SLE patients with ATO treatment, which were accompanied by reduced histone H4 and H3 acetylation in INF-γ promoter and decreased combination of RNA Pol II to the INF-γ promoter...
  68. Benleulmi M, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, et al. Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails. Retrovirology. 2017;14:54 pubmed publisher
    ..We also demonstrate direct interactions between IN and the amino-terminal tail of human histone H4 in vitro...
  69. Huen M, Sy S, van Deursen J, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem. 2008;283:11073-7 pubmed publisher
    ..The histone methyltransferase SET8 (also known as Pr-Set7) was previously reported to monomethylate Lys(20) of histone H4. However, the temporal and spatial control of SET8 activity remains elusive...
  70. Morishita M, di Luccio E. Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1. Biochem Biophys Res Commun. 2011;412:214-9 pubmed publisher
    ..Finally, we prospect the special value of this regulatory region for developing specific and selective NSD inhibitors for the epigenetic therapy of cancers. ..
  71. Chen J, Zheng Z, Chen Y, Li J, Qian S, Shi Y, et al. Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase II?. PLoS ONE. 2016;11:e0153330 pubmed publisher
    ..and found that benzene poisoning decreased the expression and activity of Topo II?, and impaired acetylation of histone H4 and H3...
  72. Puddu F, Salguero I, Herzog M, Geisler N, Costanzo V, Jackson S. Chromatin determinants impart camptothecin sensitivity. EMBO Rep. 2017;18:1000-1012 pubmed publisher
    ..Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by ..
  73. Sałkowska A, Karaś K, Walczak Drzewiecka A, Dastych J, Ratajewski M. Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of ROR?T in human lymphocytes. J Leukoc Biol. 2017;: pubmed publisher
    ..butyrate and apicidin, led to the induction of the ROR?T gene, which was associated with an increase in histone H4 acetylation near the ROR?T proximal promoter...
  74. Leung Y, Shi L, Maurer K, Song L, Zhang Z, Petri M, et al. Interferon regulatory factor 1 and histone H4 acetylation in systemic lupus erythematosus. Epigenetics. 2015;10:191-9 pubmed publisher
    ..Furthermore, IRF1 directly interacts with chromatin modifying enzymes, supporting a model where recruitment to specific target genes is mediated in part by IRF1. ..
  75. Lahn B, Tang Z, Zhou J, Barndt R, Parvinen M, Allis C, et al. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc Natl Acad Sci U S A. 2002;99:8707-12 pubmed
    ..It has long been thought that this process is facilitated by the hyperacetylation of histone H4. However, the responsible histone acetyltransferase enzymes are yet to be identified...
  76. Vaquero A, Scher M, Lee D, Erdjument Bromage H, Tempst P, Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell. 2004;16:93-105 pubmed
    ..SirT1 deacetylates histone polypeptides with a preference for histone H4 lysine 16 (H4-K16Ac) and H3 lysine 9 (H3-K9Ac) in vitro...
  77. Kim J, Cho E, Kim S, Youn H. CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat Struct Mol Biol. 2005;12:423-8 pubmed publisher
    ..These results suggest a novel mechanism whereby CtBP1 serves as an energy-sensing repressor of histone acetyltransferase(s) and thus affects general transcription...
  78. Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B. Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2. FEBS Lett. 2010;584:3901-8 pubmed publisher
    ..mechanism for how the N-terminal bromodomain of human BRD2 (BRD2-BD1) deciphers the mono-acetylated status of histone H4 tail was recently reported...
  79. Trojer P, Cao A, Gao Z, Li Y, Zhang J, Xu X, et al. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell. 2011;42:438-50 pubmed publisher
    ..Our findings highlight a PcG/MBT collaboration that attains repressive chromatin without entailing histone lysine methylation marks. ..
  80. Chitale S, Richly H. DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites. J Cell Biol. 2018;217:527-540 pubmed publisher
    ..We show that MMSET is required for efficient NER and that it catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2). H4K20me2 at DNA damage sites facilitates the recruitment of the NER factor XPA...
  81. Yan D, Zhang Y, Niu L, Yuan Y, Cao X. Identification and characterization of two closely related histone H4 arginine 3 methyltransferases in Arabidopsis thaliana. Biochem J. 2007;408:113-21 pubmed
    ..Both AtPRMT1a and AtPRMT1b methylated histone H4, H2A, and myelin basic protein in vitro...
  82. Kaczmarczyk A, Allahverdi A, Brouwer T, Nordenskiöld L, Dekker N, van Noort J. Single-molecule force spectroscopy on histone H4 tail-cross-linked chromatin reveals fiber folding. J Biol Chem. 2017;292:17506-17513 pubmed publisher
    ..Here, using histone H4-V21C and histone H2A-E64C mutations, we employed single-molecule force spectroscopy to measure the unfolding of ..
  83. Mitra P, Xie R, Medina R, Hovhannisyan H, Zaidi S, Wei Y, et al. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol. 2003;23:8110-23 pubmed
    ..characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family...
  84. Hofmann W, Stojiljkovic L, Fuchsova B, Vargas G, Mavrommatis E, Philimonenko V, et al. Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol. 2004;6:1094-101 pubmed
    ..Together, these data suggest a fundamental role for actin in the initiation of transcription by RNA polymerase II. ..
  85. Schultz D, Ayyanathan K, Negorev D, Maul G, Rauscher F. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 2002;16:919-32 pubmed
    ..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression. ..
  86. Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert F, Cheema P, et al. Human ING1 proteins differentially regulate histone acetylation. J Biol Chem. 2002;277:29832-9 pubmed
    ..ING1.PCNA protein complexes. ..
  87. Choi J, Kim B, Heo K, Kim K, Kim H, Zhan Y, et al. Purification and characterization of cellular proteins associated with histone H4 tails. J Biol Chem. 2007;282:21024-31 pubmed
    The histone H4 N-terminal tail has long been regarded as a major regulator in chromatin structure and function...
  88. Sims J, Rice J. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Mol Cell Biol. 2008;28:4459-68 pubmed publisher
    ..We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysine 9 (H3K9); however, the mechanisms that establish this code and its function in ..
  89. Xiong L, Zhang J, Yuan B, Dong X, Jiang X, Wang Y. Global proteome quantification for discovering imatinib-induced perturbation of multiple biological pathways in K562 human chronic myeloid leukemia cells. J Proteome Res. 2010;9:6007-15 pubmed publisher
    ..We also found, by assessing alteration in the acetylation level in histone H4 upon imatinib treatment, that the imatinib-induced hemoglobinization and erythroid differentiation in K562 cells ..
  90. Mavrakis K, McDonald E, Schlabach M, Billy E, Hoffman G, deWeck A, et al. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science. 2016;351:1208-13 pubmed publisher
    ..Inhibitors of PRMT5 that leverage this dysregulated metabolic state merit further investigation as a potential therapy for MTAP/CDKN2A-deleted tumors. ..
  91. Machida S, Sekine S, Nishiyama Y, Horikoshi N, Kurumizaka H. Structural and biochemical analyses of monoubiquitinated human histones H2B and H4. Open Biol. 2016;6: pubmed publisher
    Monoubiquitination is a major histone post-translational modification. In humans, the histone H2B K120 and histone H4 K31 residues are monoubiquitinated and may form transcriptionally active chromatin...
  92. Fujita K, Shimazaki N, Ohta Y, Kubota T, Ibe S, Toji S, et al. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2003;8:559-71 pubmed
    ..The enzymatic consequence of the TdIF2/TdT complex is the reduction of TdT activity in vitro. TdIF2 would function as a chromatin remodeling protein at the N region synthesis. ..