Gene Symbol: HIST2H2BE
Description: histone cluster 2 H2B family member e
Alias: GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, histone H2B type 2-E, H2B histone family, member Q, histone 2, H2be, histone H2B-GL105, histone H2B.q, histone cluster 2, H2be
Species: human
Products:     HIST2H2BE

Top Publications

  1. Joo H, Jones A, Yang C, Zhai L, Smith A, Zhang Z, et al. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J Biol Chem. 2011;286:7190-201 pubmed publisher
    ..One such modification is histone ubiquitination, which primarily targets histone H2A and H2B. Although ubiquitination of H2A and H2B has been generally linked to gene silencing and gene activation, ..
  2. Yoon H, Choi Y, Cole P, Wong J. Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol Cell Biol. 2005;25:324-35 pubmed
    ..TBL1 and TBLR1 bind preferentially to hypoacetylated histones H2B and H4 in vitro and have a critical role in targeting the corepressor complexes to chromatin in vivo...
  3. Ooi S, Qiu C, Bernstein E, Li K, Jia D, Yang Z, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007;448:714-7 pubmed
    ..These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2. ..
  4. Jackson S, Brooks W, Jackson V. Dynamics of the interactions of histones H2A,H2B and H3,H4 with torsionally stressed DNA. Biochemistry. 1994;33:5392-403 pubmed
    The interactions of histones H2A,H2B and H3,H4 with closed circular DNA maintained in either a positively or negatively coiled state have been studied...
  5. Kutney S, Hong R, Macfarlan T, Chakravarti D. A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J Biol Chem. 2004;279:30850-5 pubmed
    ..Together, these data define a novel in vivo mechanistic role for the mammalian Set/TAF-Ibeta and pp32 proteins as transducers of chromatin signaling by integrating chromatin hypoacetylation and transcriptional repression. ..
  6. Wu J, Huen M, Lu L, Ye L, Dou Y, Ljungman M, et al. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2009;29:849-60 pubmed publisher
    ..interaction motif containing 1), a functional partner of BRCA1, recognizes ubiquitinated histones H2A and H2B. The interaction between RAP80 and ubiquitinated histones H2A and H2B is increased following DNA damage...
  7. Li X, Trojer P, Matsumura T, Treisman J, Tanese N. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. Mol Cell Biol. 2010;30:1673-88 pubmed publisher
    ..The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro...
  8. Rodriguez P, Munroe D, Prawitt D, Chu L, Bric E, Kim J, et al. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Genomics. 1997;44:253-65 pubmed
    ..Our results, coupled with tumor suppression assays in G401 WT cells, do not support a role for NAP-2 in the etiology of WT. A putative role for NAP-2 in regulating cellular differentiation is discussed. ..
  9. Cheung W, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen C, et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113:507-17 pubmed
    ..Here we report that phosphorylation of histone H2B at serine 14 (S14) correlates with cells undergoing programmed cell death in vertebrates...

More Information

Publications138 found, 100 shown here

  1. Shawber C, Lin L, Gnarra M, Sauer M, Papaioannou V, KITAJEWSKI J, et al. Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus. Vasc Cell. 2015;7:9 pubmed publisher
    ..CBF:H2B-Venus Notch reporter transgenic mice were used to determine Notch activity...
  2. Terova G, Cattaneo A, Preziosa E, Bernardini G, Saroglia M. Impact of acute stress on antimicrobial polypeptides mRNA copy number in several tissues of marine sea bass (Dicentrarchus labrax). BMC Immunol. 2011;12:69 pubmed publisher
    ..in Genbank database the cDNA sequences encoding for hemoglobin-β-like protein (Hb-LP) [GeneBank: JN410659], H2B histone-like protein 1 (HLP1) GenBank: JN410660], and HLP2 [GenBank: JN410661]...
  3. Basnet H, Su X, Tan Y, Meisenhelder J, Merkurjev D, Ohgi K, et al. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014;516:267-71 pubmed publisher
    ..Mutation of Tyr 57 causes a loss of H2B mono-ubiquitination as well as H3K4me3 and H3K79me3, histone marks associated with active transcription...
  4. Miller M, Barrett Wilt G, Hua Z, Vierstra R. Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Proc Natl Acad Sci U S A. 2010;107:16512-7 pubmed publisher
    ..Targets of particular interest include histone H2B, components in the LEUNIG/TOPLESS corepressor complexes, and proteins that control histone acetylation and DNA ..
  5. Leandro de Jesus T, Calderano S, Vitorino F, Llanos R, Lopes M, de Araújo C, et al. Quantitative Proteomic Analysis of Replicative and Nonreplicative Forms Reveals Important Insights into Chromatin Biology of Trypanosoma cruzi. Mol Cell Proteomics. 2017;16:23-38 pubmed publisher
    ..On the other hand, the nonreplicative stages have an enrichment of a histone H2B variant...
  6. Yoshikawa G, Blanc Mathieu R, Song C, Kayama Y, Mochizuki T, Murata K, et al. Medusavirus, a Novel Large DNA Virus Discovered from Hot Spring Water. J Virol. 2019;93: pubmed publisher
    ..Furthermore, the medusavirus genome harbored genes for all five types of histones (H1, H2A, H2B, H3, and H4) and one DNA polymerase, which are phylogenetically placed at the root of the eukaryotic clades...
  7. Lin H, Zheng D, Li Y, Wang N, Chen S, Fu Y, et al. Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria. Biomed Microdevices. 2016;18:41 pubmed publisher
    ..no fluorescence signal was detected in PMVs from cells whose nucleus was labeled with an EGFP-tagged histone H2B. Consistently, qRT-PCR measurement showed that mRNA, miRNA and mitochondrial DNA decreased slightly; while nuclear ..
  8. Bochner R, Samuelov L, Sarig O, Li Q, Adase C, Isakov O, et al. Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis. J Invest Dermatol. 2017;137:385-393 pubmed publisher
    ..Using ex vivo live imaging, small interfering RNA knockdown of calpain 12 in skin from K14-H2B GFP mice led to significant hair follicle catagen transformation compared with controls...
  9. Zhang K, Li L, Zhu M, Wang G, Xie J, Zhao Y, et al. Comparative analysis of histone H3 and H4 post-translational modifications of esophageal squamous cell carcinoma with different invasive capabilities. J Proteomics. 2015;112:180-9 pubmed publisher
    Eukaryotic DNA is packaged into a chromatin with the help of four core histones (H2A, H2B, H3, and H4). Diverse histone post-translational modifications (PTMs) are hence involved in the regulation of gene transcription...
  10. Voss S, San Marina S, Oldenburg M, Ekbom D, Madden B, Charlesworth M, et al. Histone Variants as Stem Cell Biomarkers for Long-Term Injection Medialization Laryngoplasty. Laryngoscope. 2018;128:E402-E408 pubmed publisher
    ..with open chromatin states) were overrepresented in the MACD+ADSC group, whereas structural histones H2A, H2B, and H4 were not...
  11. Sethi G, Shanmugam M, Arfuso F, Kumar A. Role of RNF20 in cancer development and progression - a comprehensive review. Biosci Rep. 2018;38: pubmed publisher
    ..Any deregulation of this core group of enzymes often leads to cancer development. Ubiquitylation of histone H2B in mammalian cells was identified over three decades ago...
  12. Lilja T, Wallenborg K, Björkman K, Albage M, Eriksson M, Lagercrantz H, et al. Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients. Epigenetics. 2013;8:246-51 pubmed publisher
    ..genes BDNF and DLX5 in lymphocytes from RTT patients and human controls, and analyzed the density of histones H3, H2B and H1, as well as the levels of methylation and acetylation on selected lysines of histone H3...
  13. Namachivayam K, Mohankumar K, Arbach D, Jagadeeswaran R, Jain S, Natarajan V, et al. All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2. PLoS ONE. 2015;10:e0134003 pubmed publisher
    ..AtRA increased phospho-ATF2 binding to the TGF-β2 promoter and increased histone H2B acetylation in the TGF-β2 nucleosome, which is typically associated with transcriptional activation...
  14. Yin L, Li F, Li J, Yang X, Xie X, Xue L, et al. Chronic Intermittent Ethanol Exposure Induces Upregulation of Matrix Metalloproteinase-9 in the Rat Medial Prefrontal Cortex and Hippocampus. Neurochem Res. 2019;: pubmed publisher
    ..analyses identified potential MMP-9-interacting proteins, including Itgb1, Src, Eef1a2, tubulin, actin, and histone H2B. These results demonstrate that both acute and CIE exposure induced increases in MMP-9 expression in the mPFC and ..
  15. Moreno E, Schwartz J, Calvo A, Blanco L, Larrea E, Irache J, et al. Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp. Int J Pharm. 2017;533:236-244 pubmed publisher
    ..loaded a MN device with 60?g of a plasmid DNA cocktail encoding the Leishmania infantum nucleosomal histones H2A, H2B, H3 and H4 and compared its immunogenicity and protective capacity against conventional s.c. or i.d...
  16. Zhao Y, Upadhyay S, Lin X. PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis. MBio. 2018;9: pubmed publisher
    ..Intriguingly, Pas3 interacts with Bre1, which is required for Cryptococcus histone H2B monoubiquitination (H2Bub1) and H3 lysine 4 dimethylation (H3K4me2), two histone modifications known to be ..
  17. Toh K, Ramdas N, Shivashankar G. Actin cytoskeleton differentially alters the dynamics of lamin A, HP1α and H2B core histone proteins to remodel chromatin condensation state in living cells. Integr Biol (Camb). 2015;7:1309-17 pubmed publisher
    ..these fluorescence dynamics assays, we also demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1α protein dynamics with chromatin...
  18. Shaban N, Harvey S, Perrino F, Hollis T. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. J Biol Chem. 2010;285:3617-24 pubmed publisher
    ..DNA hybrids during cell death. Mammalian RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity...
  19. Garnica Vergara A, Barrera Ortiz S, Muñoz Parra E, Raya González J, Méndez Bravo A, Macías Rodríguez L, et al. The volatile 6-pentyl-2H-pyran-2-one from Trichoderma atroviride regulates Arabidopsis thaliana root morphogenesis via auxin signaling and ETHYLENE INSENSITIVE 2 functioning. New Phytol. 2016;209:1496-512 pubmed publisher
    ..confocal imaging, the effects of 6-PP on root morphogenesis were found to be correlated with DR5:GFP, DR5:VENUS, H2B::GFP, PIN1::PIN1::GFP, PIN2::PIN2::GFP, PIN3::PIN3::GFP and PIN7::PIN7::GFP gene expression...
  20. So C, Ramachandran S, Martin A. E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. Mol Cell Biol. 2019;39: pubmed publisher
    ..RNF20/RNF40-mediated monoubiquitination of histone H2B on lysine 120 (H2Bub) has been suggested as a potential mediator of DSB repair, although the nature and function of ..
  21. Xie L, Li J, Deng W, Yu Z, Fang W, Chen M, et al. Proteomic analysis of lysine succinylation of the human pathogen Histoplasma capsulatum. J Proteomics. 2017;154:109-117 pubmed publisher
    ..13 lysine succinylation sites on histones including H2A, H2B, H3 and H4 in H. capsulatum were firstly reported...
  22. Reddy P, Ubhe S, Sirwani N, Lohokare R, Galande S. Rapid divergence of histones in Hydrozoa (Cnidaria) and evolution of a novel histone involved in DNA damage response in hydra. Zoology (Jena). 2017;123:53-63 pubmed publisher
    ..Genomic organization of canonical histone genes revealed the presence of H2A-H2B and H3-H4 paired clusters in high frequency and also a cluster with all core histones along with H1...
  23. Petty E, Lafon A, Tomlinson S, Mendelsohn B, Pillus L. Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics. 2016;203:1693-707 pubmed publisher
    ..of acetylation-phosphorylation cross-talk, RTS1 high-copy rescue of gcn5? growth requires two residues of H2B that are phosphorylated in human cells...
  24. Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, et al. FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. J Biol Chem. 2015;290:27297-310 pubmed publisher
    ..FACT interacts specifically with histones H2A/H2B to affect assembly and disassembly of nucleosomes, as well as transcription elongation...
  25. Török A, Gornik S. Sperm Nuclear Basic Proteins of Marine Invertebrates. Results Probl Cell Differ. 2018;65:15-32 pubmed publisher
    ..all metazoans, DNA is packaged into tightly folded and dynamically accessible chromatin by canonical histones H2A, H2B, H3 and H4...
  26. Chu F, Haley S, Zidovska A. On the origin of shape fluctuations of the cell nucleus. Proc Natl Acad Sci U S A. 2017;114:10338-10343 pubmed publisher
    ..lamin A, and of the chromatin globule surface (CGS) underneath the NE, visualized by fluorescently labeled histone H2B. Our findings reveal that fluctuation amplitudes of both CGS and NE monotonously decrease during the cell cycle, ..
  27. Soe K, Devaiah B, Singer D. Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity. Biochim Biophys Acta. 2013;1829:1184-90 pubmed publisher
    ..phosphorylating the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF and histone H2B. Like TAF1, CIITA autophosphorylates, affecting its interaction with TAF7...
  28. Nayak S, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja T, et al. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015;6:214-24 pubmed publisher
    ..Future studies addressing endocrine response should include a potential role of these currently understudied histone variants. ..
  29. Mikheyeva I, Grady P, Tamburini F, Lorenz D, Cam H. Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex. PLoS Genet. 2014;10:e1004740 pubmed publisher
    ..cerevisiae, the regulation of Set1 protein level is not coupled to the status of H3K4me or histone H2B ubiquitination by the HULC complex...
  30. Tonoyama Y, Shinya M, Toyoda A, Kitano T, Oga A, Nishimaki T, et al. Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS). Comp Biochem Physiol C Toxicol Pharmacol. 2018;209:54-62 pubmed publisher
    ..Immunostaining of primary cultured cells from caudal fins and visualization of nuclei using H2B-GFP fusion proteins revealed an abnormal nuclear shape in the mutants both in vitro and in vivo...
  31. Sommer W, Knöfel A, Izykowski N, Oldhafer F, Avsar M, Jonigk D, et al. Physical exercise reduces transplant arteriosclerosis in a mouse aorta transplantation model. J Thorac Cardiovasc Surg. 2015;149:330-7 pubmed publisher
    ..Segments of the thoracic aorta from C57.Bl6 (H2b) or C3H.HeJ (H2k) mice were transplanted into the abdominal aortas of CBA...
  32. Sinha I, Kumar S, Poonia P, Sawhney S, Natarajan K. Functional specialization of two paralogous TAF12 variants by their selective association with SAGA and TFIID transcriptional regulatory complexes. J Biol Chem. 2017;292:6047-6055 pubmed publisher
    ..human fungal pathogen, contains two paralogous TAF12 genes, CaTAF12L and CaTAF12, encoding H2B-like histone-fold domain-containing variants...
  33. Nagai M, Shimada S, Fujii Y, Moriyama H, Oba M, Katayama Y, et al. H2 genotypes of G4P[6], G5P[7], and G9[23] porcine rotaviruses show super-short RNA electropherotypes. Vet Microbiol. 2015;176:250-6 pubmed publisher
    ..The NSP5 gene segments of these strains were clustered within the H2b genotype with super-short human RVA strains...
  34. Zhang W, Yeung C, Wu L, Yuen K. E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae. elife. 2017;6: pubmed publisher
    ..ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair, ensuring ..
  35. Streubel G, Bracken A. MED23: a new Mediator of H2B monoubiquitylation. EMBO J. 2015;34:2863-4 pubmed publisher
    ..2015) report that the MED23 subunit of the Mediator complex physically associates with the heterodimeric RNF20/40 E3‐ligase complex to facilitate the monoubiquitylation of histone H2B on gene bodies of actively transcribed genes.
  36. Kim H, Cho J, Park H, Yoon H, Kim M, Kim S. Endotoxin-neutralizing antimicrobial proteins of the human placenta. J Immunol. 2002;168:2356-64 pubmed
    ..Characterization of these proteins revealed that they are identical to histones H2A and H2B. Histones H2A and H2B showed dose-dependent inhibition of the endotoxin activity of LPS and inhibited this activity ..
  37. Wu L, Li L, Zhou B, Qin Z, Dou Y. H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. Mol Cell. 2014;54:920-931 pubmed publisher
    Histone H2B ubiquitination plays an important role in transcription regulation. It has been shown that H2B ubiquitination is regulated by multiple upstream events associated with elongating RNA polymerase...
  38. Gaykalova D, Kulaeva O, Volokh O, Shaytan A, Hsieh F, Kirpichnikov M, et al. Structural analysis of nucleosomal barrier to transcription. Proc Natl Acad Sci U S A. 2015;112:E5787-95 pubmed publisher
    ..DNA is displaced from one of the H2A/H2B dimers that remains associated with the octamer...
  39. Latrick C, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, et al. Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1. Nat Struct Mol Biol. 2016;23:309-16 pubmed publisher
    ..Z-deposition chaperone. The 2.7-Å-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z αC helix...
  40. Debelouchina G, Gerecht K, Muir T. Ubiquitin utilizes an acidic surface patch to alter chromatin structure. Nat Chem Biol. 2017;13:105-110 pubmed publisher
    Ubiquitylation of histone H2B, associated with gene activation, leads to chromatin decompaction through an unknown mechanism...
  41. Raulf A, Voeltz N, Korzus D, Fleischmann B, Hesse M. Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes. J Vis Exp. 2017;: pubmed publisher
    ..We use two published transgenic systems: the Myh6-H2B-mCh transgenic mouse line, for the unequivocal identification of cardiomyocyte nuclei, and the CAG-eGFP-anillin ..
  42. Baranova S, Dmitrienok P, Ivanisenko N, Buneva V, Nevinsky G. Antibodies to H2a and H2b histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones. Mol Biosyst. 2017;13:1090-1101 pubmed publisher
    ..Using MALDI mass spectrometry the sites of H2a and H2b histone cleavage by anti-histone IgGs were determined for the first time...
  43. Baboshina O, Haas A. Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5. J Biol Chem. 1996;271:2823-31 pubmed
    ..Therefore, the linkage specificity exhibited by these E2 isozymes depends on their catalytic context with respect to isopeptide ligase. ..
  44. Yang X, Ogryzko V, Nishikawa J, Howard B, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996;382:319-24 pubmed
    ..Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase. ..
  45. Zhou W, Zhu P, Wang J, Pascual G, Ohgi K, Lozach J, et al. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell. 2008;29:69-80 pubmed publisher
    ..We suggest that distinct H2A ubiquitinases, each recruited based on interactions with different corepressor complexes, contribute to distinct transcriptional repression programs. ..
  46. Domínguez Bernal G, Horcajo P, Orden J, Ruiz Santa Quiteria J, de la Fuente R, Ordóñez Gutiérrez L, et al. HisAK70: progress towards a vaccine against different forms of leishmaniosis. Parasit Vectors. 2015;8:629 pubmed publisher
    ..Here, we describe the use of a HisAK70 DNA-vaccine encoding seven Leishmania genes (H2A, H2B, H3, H4, A2, KMP11 and HSP70) for vaccination of mice to assess the induction of a resistant phenotype against VL ..
  47. Ohtomo H, Akashi S, Moriwaki Y, Okuwaki M, Osakabe A, Nagata K, et al. C-terminal acidic domain of histone chaperone human NAP1 is an efficient binding assistant for histone H2A-H2B, but not H3-H4. Genes Cells. 2016;21:252-63 pubmed publisher
    Nucleosome assembly protein 1 (NAP1) binds both the (H3-H4)2 tetramer and two H2A-H2B dimers, mediating their sequential deposition on DNA. NAP1 contains a C-terminal acidic domain (CTAD) and a core domain that promotes dimer formation...
  48. Prasad R, D Arcy S, Hada A, Luger K, Bartholomew B. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes. Mol Cell Biol. 2016;36:2262-71 pubmed publisher
    ..in Saccharomyces cerevisiae Extensive mutational analysis of Nap1 has revealed that Nap1 affinity for histones H2A-H2B and H3-H4 and its ability to displace histones from DNA are required for Nap1 to enhance RSC-mediated disassembly...
  49. Kiripolsky J, Shen L, Liang Y, Li A, Suresh L, Lian Y, et al. Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2b/J mouse model. Clin Immunol. 2017;183:225-232 pubmed publisher
    ..We identified numerous autoantibodies, including those directed against salivary proteins. In conclusion, the NOD.B10 model recapitulates both local and systemic pSS disease and represents an excellent model for translational studies. ..
  50. Keren I, Citovsky V. Activation of gene expression by histone deubiquitinase OTLD1. Epigenetics. 2017;12:584-590 pubmed publisher
    ..activity of OTLD1 involves occupation of the target chromatin by this enzyme, deubiquitination of monoubiquitylated H2B within the occupied regions, and formation of the euchromatic histone acetylation and methylation marks...
  51. Lawson A, Bak D, Shannon D, Long M, Vijaykumar T, Yu R, et al. Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Oncotarget. 2017;8:51296-51316 pubmed publisher
    ..Our work also demonstrates that PEITC reduces the mono-ubiquityl histones H2A and H2B. Understanding the mechanism of action of ITCs should facilitate their use as therapeutic agents.
  52. Frohm M, Gunne H, Bergman A, Agerberth B, Bergman T, Boman A, et al. Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem. 1996;237:86-92 pubmed
    ..The material corresponding to HPLC peaks of the wound fluid extract was identified as: histone H2B fragments 1-11,1-15 and 1-16, intact thymosin beta-4, defensins HNP1, 2 and 3, lysozyme and the peptide antibiotic ..
  53. Li T, Guan J, Huang Z, Hu X, Zheng X. RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair. J Cell Sci. 2014;127:2238-48 pubmed publisher
    ..Our findings elucidate the relationship of H2A ubiquitylation and neddylation, and suggest a novel modulatory approach to DNA damage repair through the neddylation pathway. ..
  54. Vlijm R, Lee M, Ordu O, Boltengagen A, Lusser A, Dekker N, et al. Comparing the Assembly and Handedness Dynamics of (H3.3-H4)2 Tetrasomes to Canonical Tetrasomes. PLoS ONE. 2015;10:e0141267 pubmed publisher
    Eukaryotic nucleosomes consists of an (H3-H4)2 tetramer and two H2A-H2B dimers, around which 147 bp of DNA are wrapped in 1.7 left-handed helical turns...
  55. Burg J, Gonzalez J, Maksimchuk K, McCafferty D. Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. Biochemistry. 2016;55:1652-62 pubmed publisher
    ..demethylation activity, which is consistent with H3 being the preferred histone substrate of KDM1A versus H2A, H2B, and H4...
  56. Zhang W, Roy S. The zebrafish fast myosin light chain mylpfa:H2B-GFP transgene is a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo. Gene Expr Patterns. 2016;20:106-10 pubmed publisher
    ..Here, we report the generation of a stable transgenic zebrafish strain that expresses the Histone 2B-GFP (H2B-GFP) fusion protein in the nuclei of all fast-twitch muscle fibers under the control of the fast-twitch muscle-..
  57. Jiang E. Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study. Mutat Res. 2016;787:7-14 pubmed publisher
    ..In the current study, HeLa CENP B-GFP H2B-mCherry cells were constructed in which histone 2B (H2B) and centromere protein B (CENP B) were expressed as fusion ..
  58. Helland Ø, Popa M, Bischof K, Gjertsen B, McCormack E, Bjørge L. The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer. PLoS ONE. 2016;11:e0158208 pubmed publisher
    ..We observed increased levels of cleaved PARP and caspase-3, downregulation of cdc2 protein kinase, acetylation of H2B and higher pH2AX expression...
  59. Winkler D, Muthurajan U, Hieb A, Luger K. Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem. 2011;286:41883-92 pubmed publisher
    ..Together, the data reveal that specific FACT subunits synchronize interactions with various target sites on individual nucleosomes to generate a high affinity binding event and promote reorganization. ..
  60. Bleuyard J, Buisson R, Masson J, Esashi F. ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. EMBO Rep. 2012;13:135-41 pubmed publisher
    ..These results suggest that PALB2 chromatin association via ChAM facilitates PALB2 function in the cellular resistance to DNA damage. ..
  61. Kato A, Komatsu K. RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair. Genes (Basel). 2015;6:592-606 pubmed publisher
    ..The ubiquitylation of histone H2B by RNF20 E3 ligase was recently found to be a DNA damage-induced histone modification...
  62. Choi K, Kim J, Müller S, Oh M, Underwood C, Henderson I, et al. Regulation of MicroRNA-Mediated Developmental Changes by the SWR1 Chromatin Remodeling Complex. Plant Physiol. 2016;171:1128-43 pubmed publisher
    The ATP-dependent SWR1 chromatin remodeling complex (SWR1-C) exchanges the histone H2A-H2B dimer with the H2A.Z-H2B dimer, producing variant nucleosomes...
  63. Liefke R, Karwacki Neisius V, Shi Y. EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape. Mol Cell. 2016;64:659-672 pubmed publisher
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    ..and response to stress, controls cytokinesis and prevents tetraploidization through its effects on histone H2B. HIPK2 binds and phosphorylates histone H2B at S14 (H2B-S14(P)), and the two proteins colocalize at the midbody...
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