Gene Symbol: HIST1H2BM
Description: histone cluster 1 H2B family member m
Alias: H2B/e, H2BFE, dJ160A22.3, histone H2B type 1-M, H2B histone family, member E, histone 1, H2bm, histone H2B.e, histone cluster 1, H2bm
Species: human
Products:     HIST1H2BM

Top Publications

  1. Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D. The human H2A and H2B histone gene complement. Biol Chem. 1999;380:7-18 pubmed
    ..The genes show varying expression patterns in different tumor cell lines. ..
  2. Pishas K, Drenberg C, Taslim C, Theisen E, Johnson K, Saund R, et al. Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. Mol Cancer Ther. 2018;17:1902-1916 pubmed publisher
    ..In addition, ETS1/HIST1H2BM were specifically induced/repressed, respectively following SP-2509 treatment only in our hypersensitive ..
  3. Mitsugi R, Itoh T, Fujiwara R. MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury. Toxicol Lett. 2016;263:34-43 pubmed publisher
    ..Especially, SLCO4C1, PEPCK, MT1M, HIST1H2BM, LGI1, and PLA2G2A were markedly increased or decreased in the miR-877-5p overexpressing cells...
  4. Bonenfant D, Coulot M, Towbin H, Schindler P, van Oostrum J. Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. Mol Cell Proteomics. 2006;5:541-52 pubmed
    ..The analysis of core histone subtypes with their modifications provides a first step toward an understanding of the functional significance of the diversity of histone structures. ..
  5. Du Y, Gu S, Zhou J, Wang T, Cai H, Macinnes M, et al. The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest. Mol Cell Proteomics. 2006;5:1033-44 pubmed
    ..The dataset presented here demonstrates that sensitive profiling of the dynamics of functional cellular protein-protein interactions can successfully lead to the dissection of important metabolic or signaling pathways. ..
  6. Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, et al. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 2006;125:703-17 pubmed
  7. Cheung W, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen C, et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113:507-17 pubmed
    ..Our data provide evidence for a potential apoptotic "histone code." ..
  8. Zhu B, Zheng Y, Pham A, Mandal S, Erdjument Bromage H, Tempst P, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell. 2005;20:601-11 pubmed
    ..In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression. ..
  9. Golebiowski F, Kasprzak K. Inhibition of core histones acetylation by carcinogenic nickel(II). Mol Cell Biochem. 2005;279:133-9 pubmed
    ..The observed effects may contribute to neoplastic transformation of Ni(II)-exposed cells. ..

More Information


  1. Siuti N, Roth M, Mizzen C, Kelleher N, Pesavento J. Gene-specific characterization of human histone H2B by electron capture dissociation. J Proteome Res. 2006;5:233-9 pubmed
    ..Modest hyperacetylation of H2B family members was observed after sodium butyrate treatment. ..