HIST1H2BG

Summary

Gene Symbol: HIST1H2BG
Description: histone cluster 1, H2bg
Alias: H2B.1A, H2B/a, H2BFA, dJ221C16.8, H2B histone family, member A, histone 1, H2bg, histone H2B type 1-C/E/F/G/I, histone H2B.1 A, histone H2B.a
Species: human

Top Publications

  1. ncbi FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2
    Inken Wierstra
    Institute of Molecular Biology, Medical School Hannover, Germany
    FEBS J 273:4645-67. 2006
  2. pmc Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines
    Hai Hong Zhang
    Department of Rheumatism and Immunology, First Clinical Medical College affiliated to Harbin Medical University Harbin, China
    Int J Clin Exp Pathol 6:1734-46. 2013
  3. pmc Transcriptome study of differential expression in schizophrenia
    Alan R Sanders
    Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, IL 60201, USA
    Hum Mol Genet 22:5001-14. 2013
  4. doi Thermodynamic studies of U(VI) complexation with glutardiamidoxime for sequestration of uranium from seawater
    Guoxin Tian
    Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Dalton Trans 42:5690-6. 2013
  5. pmc UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells
    Jee Young An
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e37414. 2012
  6. ncbi Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:34655-7. 2002
  7. ncbi Identification of differentially expressed genes after PPM1D silencing in breast cancer
    Jenita Pärssinen
    Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
    Cancer Lett 259:61-70. 2008
  8. pmc Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology, and Shands Cancer Center, University of Florida, 1613 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9825-37. 2007
  9. ncbi Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
    Rushad Pavri
    Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 125:703-17. 2006
  10. ncbi Quantitative proteomic analysis of post-translational modifications of human histones
    Hans Christian Beck
    Danish Technological Institute, Holbergsvej 10, DK 6000 Kolding, Denmark
    Mol Cell Proteomics 5:1314-25. 2006

Research Grants

  1. PROTEIN CARBOXYL METHYLATION IN BRAIN
    DANA ASWAD; Fiscal Year: 2000
  2. Protein Methylation in Brain
    DANA ASWAD; Fiscal Year: 2005

Scientific Experts

  • Inken Wierstra
  • K R Matthews
  • Filip Golebiowski
  • Meftun Ahmed
  • DANA ASWAD
  • Guoxin Tian
  • Bing Zhu
  • Alan R Sanders
  • Hai Hong Zhang
  • Jee Young An
  • Zhen Gao
  • Lilach Moyal
  • R Das
  • Munshi Azad Hossain
  • Meredith E K Calvert
  • Robert K McGinty
  • Jenita Pärssinen
  • Rebecca L Skalsky
  • Rushad Pavri
  • Hans Christian Beck
  • Nertila Siuti
  • Debora Bonenfant
  • Danny Reinberg
  • Glen W Young
  • Craig A Mizzen
  • Scott J Howell
  • Maria Tollin
  • Matthew A Coleman
  • Wang L Cheung
  • Huck Hui Ng
  • Hun Sik Kim
  • Zhi Yi Zhang
  • Jubao Duan
  • Yu zhi Shi
  • Jianxin Shi
  • Chun Li Che
  • Yi Fang Mei
  • Eugene I Drigalenko
  • Pablo V Gejman
  • Simon J Teat
  • Winton Moy
  • Deli He
  • Jessica Freda
  • Harald H H Goring
  • Linfeng Rao
  • Euna Kim
  • Yong Jun Lee
  • Dong Hoon Han
  • Min Jae Lee
  • Yong Tae Kwon
  • Adriana Zakrzewska
  • Jun Min Jang
  • Jai Wha Seo
  • Bo Yeon Kim
  • Tae You Kim
  • Dirk G de Rooij
  • Young Dong Yoo
  • Bernhard Kuster
  • David J Chen
  • Matthias Mann
  • Gilad Mass
  • Dganit Shkedy
  • Berina Eppink
  • Moshe Oren
  • Gil Shalev
  • Yaniv Lerenthal
  • Sairei So
  • Jochen Dahm-Daphi
  • Nechama I Smorodinsky
  • Mali Gana-Weisz
  • Young Min Chung
  • Efrat Shema
  • E F Plow
  • Shih Ya Wang
  • Yosef Shiloh
  • Roland Kanaar
  • Mickey C T Hu
  • C Wilson Xu
  • Aaron Ciechanover
  • Nicole van Vliet
  • M Monestier
  • Tracy L Johnson
  • Julia M Claggett
  • Tiffany Nguyen
  • Lucy F Pemberton
  • Ritva Karhu
  • Emma Leena Alarmo
  • Tom W Muir
  • Mauno Vihinen
  • Jeffrey Shabanowitz

Detail Information

Publications35

  1. ncbi FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2
    Inken Wierstra
    Institute of Molecular Biology, Medical School Hannover, Germany
    FEBS J 273:4645-67. 2006
    ..Accordingly, dominant-negative FOXM1c proteins reduced cell growth approximately threefold, demonstrating a proliferation-stimulating function for wild-type FOXM1c...
  2. pmc Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines
    Hai Hong Zhang
    Department of Rheumatism and Immunology, First Clinical Medical College affiliated to Harbin Medical University Harbin, China
    Int J Clin Exp Pathol 6:1734-46. 2013
    ..Our results might provide potential biomarkers for gemcitabine sensitivity prediction and putative targets to overcome gemcitabine resistance in NSCLC patients. ..
  3. pmc Transcriptome study of differential expression in schizophrenia
    Alan R Sanders
    Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, IL 60201, USA
    Hum Mol Genet 22:5001-14. 2013
    ..expression of extended major histocompatibility complex (xMHC) region histones (HIST1H2BD, HIST1H2BC, HIST1H2BH, HIST1H2BG and HIST1H4K) converges with the genetic evidence from GWAS, which find the xMHC to be the most significant ..
  4. doi Thermodynamic studies of U(VI) complexation with glutardiamidoxime for sequestration of uranium from seawater
    Guoxin Tian
    Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Dalton Trans 42:5690-6. 2013
    ..The competition between glutardiamidoxime and carbonate for complexing U(VI) in 3% NaCl was also studied in comparison with the cyclic glutarimidedioxime ligand (H2A) previously studied...
  5. pmc UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells
    Jee Young An
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e37414. 2012
    ..Thus, UBR2, known as the recognition component of a major cellular proteolytic system, is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells...
  6. ncbi Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:34655-7. 2002
    ..Our study provides a new example of trans-histone regulation between modifications on different histones. In addition, it suggests that Rad6 affects telomeric silencing, at least in part, by influencing methylation of histone H3...
  7. ncbi Identification of differentially expressed genes after PPM1D silencing in breast cancer
    Jenita Pärssinen
    Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
    Cancer Lett 259:61-70. 2008
    ..Overall, our findings suggest that PPM1D contributes to breast cancer associated phenotypic characteristics by directly or indirectly affecting several important cellular signaling pathways...
  8. pmc Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology, and Shands Cancer Center, University of Florida, 1613 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9825-37. 2007
    ..Our data suggest that the efficiency with which KSHV establishes latency is dependent on multiple LANA activities, which stabilize viral genomes early after de novo infection...
  9. ncbi Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
    Rushad Pavri
    Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 125:703-17. 2006
    ....
  10. ncbi Quantitative proteomic analysis of post-translational modifications of human histones
    Hans Christian Beck
    Danish Technological Institute, Holbergsvej 10, DK 6000 Kolding, Denmark
    Mol Cell Proteomics 5:1314-25. 2006
    ..This demonstrates that mass spectrometry-based quantitative proteomic analysis of post-translational modifications is a viable approach for functional analysis of candidate drugs, such as HDAC inhibitors...
  11. ncbi FOXM1, a typical proliferation-associated transcription factor
    Inken Wierstra
    Wissmannstr 17, D 30173 Hannover, Germany
    Biol Chem 388:1257-74. 2007
    ....
  12. pmc Phosphorylation by casein kinase 2 regulates Nap1 localization and function
    Meredith E K Calvert
    Center for Cell Signaling, University of Virginia, Box 800577 HSC, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:1313-25. 2008
    ..In conclusion, our data show that Nap1 phosphorylation by CK2 appears to regulate Nap1 localization and is required for normal progression through S phase...
  13. pmc Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
    Robert K McGinty
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, New York 10065, USA
    Nature 453:812-6. 2008
    ..This work demonstrates a direct biochemical crosstalk between two modifications on separate histone proteins within a nucleosome...
  14. pmc The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA
    Munshi Azad Hossain
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    RNA 15:1515-27. 2009
    ....
  15. doi Phosphatidylserine as an anchor for plasminogen and its plasminogen receptor, histone H2B, to the macrophage surface
    R Das
    Department of Molecular Cardiology, Cleveland Clinic, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, OH 44195, USA
    J Thromb Haemost 9:339-49. 2011
    ..Histone H2B (H2B) acts as a Plg-R and its cell surface expression is up-regulated when monocytes are differentiated to macrophages via a pathway dependent on L-type Ca(2+) channels and intracellular Ca(2+)...
  16. doi Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells
    Zhen Gao
    Department of Drug Development, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    Biochem Biophys Res Commun 404:428-33. 2011
    ....
  17. pmc Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
    Lilach Moyal
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell 41:529-42. 2011
    ..Our data and previous data suggest a two-stage model for chromatin decondensation that facilitates DSB repair...
  18. ncbi Gene-specific characterization of human histone H2B by electron capture dissociation
    Nertila Siuti
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Proteome Res 5:233-9. 2006
    ..Modest hyperacetylation of H2B family members was observed after sodium butyrate treatment...
  19. ncbi Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry
    Debora Bonenfant
    Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, CH 4056 Basel, Switzerland
    Mol Cell Proteomics 5:541-52. 2006
    ..The analysis of core histone subtypes with their modifications provides a first step toward an understanding of the functional significance of the diversity of histone structures...
  20. ncbi Isolation and characterization of two human H1 histone genes within clusters of core histone genes
    W Albig
    Institut fur Biochemie, Universitat Gottingen, Federal Republic of Germany
    Genomics 10:940-8. 1991
    ..In continuation of our previous analysis of two human H1 genes, this analysis raises the number of completely sequenced H1 histone genes within clusters of core histone genes to four...
  21. ncbi Biochemical and antibacterial analysis of human wound and blister fluid
    M Frohm
    Department of Microbiology, Stockholm University, Sweden
    Eur J Biochem 237:86-92. 1996
    ..It is concluded that analysis of wound fluid yields peptide and activity patterns with novel fragments of important peptides, and quantitative differences, that can be useful to understand molecular mechanisms of wound healing further...
  22. ncbi Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay
    C Díaz-Jullien
    Departamento de Bioquimica y Biologia Molecular, Facultad de Biologia, Universidad de Santiago, Spain
    Biochim Biophys Acta 1296:219-27. 1996
    ..We discuss the possibility that Pro T alpha plays a role in chromatin remodelling...
  23. ncbi Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998
    ....
  24. ncbi Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis
    L Piredda
    Department of Biology, University of Rome Tor Vergata Rome, Italy
    FASEB J 13:355-64. 1999
    ..By contrast, the tTG-beta-tubulin interaction does not result in the cross-linking of this cytoskeletal protein, which suggests that microtubules act as the anchorage site for tTG and GST P1-1 interaction...
  25. ncbi Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B
    M Monestier
    Department of Microbiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 275:13558-63. 2000
    ..The study of the interaction between self-antigens and spontaneously occurring autoantibodies may help us elucidate the mechanisms driving the expansion of self-reactive lymphocytes...
  26. ncbi Endotoxin-neutralizing antimicrobial proteins of the human placenta
    Hun Sik Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
    J Immunol 168:2356-64. 2002
    ..Our studies suggest that histones H2A and H2B may endow the epithelium of the placenta with an antimicrobial and endotoxin-neutralizing barrier against microorganisms that invade this immune-privileged site...
  27. ncbi Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
    Wang L Cheung
    Department of Microbiology, University of Virginia Health System, Charlottesville 22908, USA
    Cell 113:507-17. 2003
    ..Our data provide evidence for a potential apoptotic "histone code."..
  28. ncbi Antimicrobial peptides in the first line defence of human colon mucosa
    Maria Tollin
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Peptides 24:523-30. 2003
    ..Combined, these results indicate that the colon mucosa is protected by a complex mixture of polypeptides, able to kill invading microbes and working in synergy as a barrier against bacterial invasion...
  29. ncbi Identification of chromatin-related protein interactions using protein microarrays
    Matthew A Coleman
    Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Proteomics 3:2101-7. 2003
    ..This is the first demonstration of an interaction between RAD51B and histone proteins that may be important for the successful repair of DNA double-strand breaks...
  30. ncbi Antimicrobial polypeptides of the human colonic epithelium
    Scott J Howell
    The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Peptides 24:1763-70. 2003
    ..These polypeptides normally reside inside cells and are proposed to contribute to the formation of the functional antimicrobial barrier of the colonic epithelium...
  31. ncbi Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B
    Glen W Young
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 280:26094-8. 2005
    ..Because PIMT has numerous substrates in cells, these findings also suggest that D-aspartate may be more common in cellular proteins than hitherto imagined and that its occurrence, in some proteins at least, is independent of animal age...
  32. ncbi Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry
    Meftun Ahmed
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    J Proteome Res 4:931-40. 2005
    ....
  33. ncbi Inhibition of core histones acetylation by carcinogenic nickel(II)
    Filip Golebiowski
    Laboratory of Comparative Carcinogenesis, NCI at Frederick, Frederick, MD, 21702 1201, USA
    Mol Cell Biochem 279:133-9. 2005
    ..The observed effects may contribute to neoplastic transformation of Ni(II)-exposed cells...
  34. ncbi Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
    Bing Zhu
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 20:601-11. 2005
    ..In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression...
  35. ncbi Human spleen histone H2B. Isolation and amino acid sequence
    Y Ohe
    J Biochem 85:615-24. 1979
    ..Thus, it is concluded that the H2B sequence of lower mammals was conserved during the evolutionary process leading to man...

Research Grants6

  1. PROTEIN CARBOXYL METHYLATION IN BRAIN
    DANA ASWAD; Fiscal Year: 2000
    ..coli that serves as an excellent substrate for rat brain PIMT. Together these investigations should provide important new insights into the significance of protein damage and repair systems in normal cell aging and in human disease. ..
  2. Protein Methylation in Brain
    DANA ASWAD; Fiscal Year: 2005
    ..Similarly, studies on CARM1 should provide important new information on how glucocorticoids regulate gene expression in the brain. ..