Gene Symbol: HIST1H2AM
Description: histone cluster 1 H2A family member m
Alias: H2A.1, H2A/n, H2AFN, dJ193B12.1, histone H2A type 1, H2A histone family, member N, histone 1, H2am, histone H2A/ptl, histone cluster 1, H2am
Species: human
Products:     HIST1H2AM

Top Publications

  1. Furlan V, Konc J, Bren U. Inverse Molecular Docking as a Novel Approach to Study Anticarcinogenic and Anti-Neuroinflammatory Effects of Curcumin. Molecules. 2018;23: pubmed publisher
    ..We firmly believe that our computational results will complement and direct future experimental studies on curcumin's anticancer activity as well as on its therapeutic effects against Alzheimer's disease. ..
  2. Burgos E, Wilczek C, Onikubo T, Bonanno J, Jansong J, Reimer U, et al. Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase. J Biol Chem. 2015;290:9674-89 pubmed publisher
    ..We propose a model in which MEP50 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site. ..
  3. Wang Y, Zhang L, Guo S, Hatefi A, Huang L. Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery. J Control Release. 2013;172:179-189 pubmed publisher
    ..TH is composed of 4 tandem repeats of the histone H2A N-terminal sequence, intervened by the cathepsin D cleavage site...
  4. Liu S, Gao J, Chen Z, Qiao X, Huang H, Cui B, et al. Comparative proteomics reveals the physiological differences between winter tender shoots and spring tender shoots of a novel tea (Camellia sinensis L.) cultivar evergrowing in winter. BMC Plant Biol. 2017;17:206 pubmed publisher
    ..Histone H4, Histone H2A.1, putative In2.1 protein and protein lin-28 homologs may also regulate the development of winter shoots and their response to adverse conditions. ..
  5. Tyagi M, Reddy D, Gupta S. Genomic characterization and dynamic methylation of promoter facilitates transcriptional regulation of H2A variants, H2A.1 and H2A.2 in various pathophysiological states of hepatocyte. Int J Biochem Cell Biol. 2017;85:15-24 pubmed publisher
    ..Collectively, the data suggests that differential DNA methylation on histone promoters is a dynamic player regulating their expression status in different pathophysiological stages of liver. ..
  6. Wang H, Wang L, Erdjument Bromage H, Vidal M, Tempst P, Jones R, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 2004;431:873-8 pubmed
    ..Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing. ..
  7. Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell. 2005;20:845-54 pubmed
    ..Our results suggest that EZH2-mediated H3-K27 methylation functions upstream of PRC1 and establishes a critical role for Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. ..
  8. Nicassio F, Corrado N, Vissers J, Areces L, Bergink S, Marteijn J, et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007;17:1972-7 pubmed
    ..Together, our results implicate USP3 as a novel chromatin modifier in the maintenance of genome integrity. ..
  9. Aihara H, Nakagawa T, Yasui K, Ohta T, Hirose S, Dhomae N, et al. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev. 2004;18:877-88 pubmed
    ..These studies reveal that NHK-1-catalyzed phosphorylation of a conserved serine/threonine residue in H2A is a new component of the histone code that might be related to cell cycle progression. ..

More Information


  1. Hagiwara T, Hidaka Y, Yamada M. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. Biochemistry. 2005;44:5827-34 pubmed
    ..These results suggest that PADI4 deiminates only a restricted site of target proteins in cells. Deimination of histones is discussed in relation to chromatin structure and function. ..
  2. Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D. The human H2A and H2B histone gene complement. Biol Chem. 1999;380:7-18 pubmed
    ..The genes show varying expression patterns in different tumor cell lines. ..
  3. Zhang Y, Griffin K, Mondal N, Parvin J. Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem. 2004;279:21866-72 pubmed
    ..These results suggest that acetylation of histones may stimulate transcription by suppressing an inhibitory phosphorylation by a kinase as MSK1. ..
  4. Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W. The relative expression of human histone H2A genes is similar in different types of proliferating cells. DNA Cell Biol. 1994;13:161-70 pubmed
    ..These findings suggest that the relative expression of the individual members of a histone gene family is independent of the type of replicating cell. ..
  5. Boyne M, Pesavento J, Mizzen C, Kelleher N. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res. 2006;5:248-53 pubmed
    ..This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle. ..
  6. Dobner T, Wolf I, Mai B, Lipp M. A novel divergently transcribed human histone H2A/H2B gene pair. DNA Seq. 1991;1:409-13 pubmed
    ..The spatial arrangement and orientation of two TATA-boxes, four CAAT-boxes, and one H2B-box within this region suggests that the linked genes share common promoter elements for transcriptional regulation. ..
  7. Roussel L, Erard M, Cayrol C, Girard J. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 2008;9:1006-12 pubmed publisher
    ..In addition, the data provide, to the best of our knowledge, the first demonstration of the existence of non-histone cellular factors that bind to the acidic pocket of the nucleosome...
  8. Bergink S, Salomons F, Hoogstraten D, Groothuis T, de Waard H, Wu J, et al. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes Dev. 2006;20:1343-52 pubmed
    ..Together our data show that monoubiquitylation of H2A forms part of the cellular response to UV damage and suggest a role of this modification in DNA repair-induced chromatin remodeling. ..
  9. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..
  10. Bonenfant D, Coulot M, Towbin H, Schindler P, van Oostrum J. Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. Mol Cell Proteomics. 2006;5:541-52 pubmed
    ..The analysis of core histone subtypes with their modifications provides a first step toward an understanding of the functional significance of the diversity of histone structures. ..
  11. Richly H, Rocha Viegas L, Ribeiro J, Demajo S, Gundem G, Lopez Bigas N, et al. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010;468:1124-8 pubmed publisher
    ..We provide here a model of the molecular mechanism of switching polycomb-repressed genes to an active state. ..
  12. Galasinski S, Louie D, Gloor K, Resing K, Ahn N. Global regulation of post-translational modifications on core histones. J Biol Chem. 2002;277:2579-88 pubmed
    ..These results provide novel evidence that global covalent modifications of chromatin-bound histones are regulated through phosphorylation-dependent mechanisms. ..
  13. Hayashi T, Ohe Y, Hayashi H, Iwai K. Human spleen histone H2A. Isolation and four variant sequences. J Biochem. 1980;88:27-34 pubmed
  14. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  15. Li X, Tian R, Gao H, Yang Y, Williams B, Gantier M, et al. Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients. Sci Rep. 2017;7:16495 pubmed publisher
    ..we provide evidence that two SLE-associated gene sets (HIST1H2BD and HIST1H2BJ; and HIST1H2BD, HIST1H2BJ, HIST1H2BH, HIST1H2AM and HIST1H4K) can be used as prognostic factors for survival prediction among cervical cancer patients.