Gene Symbol: HIST1H2AL
Description: histone cluster 1 H2A family member l
Alias: H2A.i, H2A/i, H2AFI, dJ193B12.9, histone H2A type 1, H2A histone family, member I, H2A.1, histone 1, H2al, histone H2A/ptl, histone cluster 1, H2al
Species: human
Products:     HIST1H2AL

Top Publications

  1. Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, et al. Identification of commonly altered genes between in major depressive disorder and a mouse model of depression. Sci Rep. 2017;7:3044 pubmed publisher
    ..Of the six common genes identified between patients and mice, five genes (SLC35A3, HIST1H2AL, YEATS4, ERLIN2, and PLPP5) were confirmed to be downregulated in patients with MDD by quantitative real-time ..
  2. Tsui C, Inouye C, Levy M, Lu A, Florens L, Washburn M, et al. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Proc Natl Acad Sci U S A. 2018;115:E2734-E2741 pubmed publisher
  3. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..
  4. Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D. The human H2A and H2B histone gene complement. Biol Chem. 1999;380:7-18 pubmed
    ..The genes show varying expression patterns in different tumor cell lines. ..
  5. Roussel L, Erard M, Cayrol C, Girard J. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 2008;9:1006-12 pubmed publisher
    ..In addition, the data provide, to the best of our knowledge, the first demonstration of the existence of non-histone cellular factors that bind to the acidic pocket of the nucleosome...
  6. Richly H, Rocha Viegas L, Ribeiro J, Demajo S, Gundem G, Lopez Bigas N, et al. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010;468:1124-8 pubmed publisher
    ..We provide here a model of the molecular mechanism of switching polycomb-repressed genes to an active state. ..
  7. Boyne M, Pesavento J, Mizzen C, Kelleher N. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res. 2006;5:248-53 pubmed
    ..This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle. ..
  8. Nicassio F, Corrado N, Vissers J, Areces L, Bergink S, Marteijn J, et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007;17:1972-7 pubmed
    ..Together, our results implicate USP3 as a novel chromatin modifier in the maintenance of genome integrity. ..
  9. Albig W, Meergans T, Doenecke D. Characterization of the H1.5 gene completes the set of human H1 subtype genes. Gene. 1997;184:141-8 pubmed
    ..The H2B sequence shows no typical regulatory elements and no complete ORF, therefore we consider it as a pseudogene. The expression of the H1.5 gene was examined in several cell lines. ..

More Information


  1. Li X, Tian R, Gao H, Yang Y, Williams B, Gantier M, et al. Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients. Sci Rep. 2017;7:16495 pubmed publisher
  2. Du Clos T, Zlock L, Marnell L. Definition of a C-reactive protein binding determinant on histones. J Biol Chem. 1991;266:2167-71 pubmed
    ..Thus we have defined the first reported CRP binding determinant on a protein. ..
  3. Carrier F, Georgel P, Pourquier P, Blake M, Kontny H, Antinore M, et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol. 1999;19:1673-85 pubmed
    ..Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins. ..
  4. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  5. Zhang Y, Sun Z, Iratni R, Erdjument Bromage H, Tempst P, Hampsey M, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998;1:1021-31 pubmed
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms. ..
  6. Kzhyshkowska J, Rusch A, Wolf H, Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem J. 2003;371:385-93 pubmed
    ..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation. ..