HIST1H2AL

Summary

Gene Symbol: HIST1H2AL
Description: histone cluster 1, H2al
Alias: H2A.i, H2A/i, H2AFI, dJ193B12.9, H2A histone family, member I, H2A.1, histone 1, H2al, histone H2A type 1
Species: human

Top Publications

  1. ncbi Selection of reference genes for quantitative real-time PCR in equine in vivo and fresh and frozen-thawed in vitro blastocysts
    Katrien Smits
    Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    BMC Res Notes 2:246. 2009
  2. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
  3. ncbi Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair
    T Ohshige
    Department of Biochemistry, Miyazaki Medical College, Japan
    Gene 131:193-9. 1993
  4. ncbi Characterization of the H1.5 gene completes the set of human H1 subtype genes
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitaet Goettingen, Germany
    Gene 184:141-8. 1997
  5. ncbi SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
    Y Zhang
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School Piscataway, New Jersey 08854, USA
    Mol Cell 1:1021-31. 1998
  6. ncbi Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
    F Carrier
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Mol Cell Biol 19:1673-85. 1999
  7. ncbi The human H2A and H2B histone gene complement
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    Biol Chem 380:7-18. 1999
  8. ncbi Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia Kzhyshkowska
    Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Biochem J 371:385-93. 2003

Research Grants

  1. RADIATION INDUCED RNA BINDING PROTEINS
    France Carrier; Fiscal Year: 2002
  2. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2007
  3. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2009

Scientific Experts

  • Julia Kzhyshkowska
  • F Carrier
  • Karen Goossens
  • Katrien Smits
  • W Albig
  • Luc Peelman
  • Jo Vandesompele
  • Maarten Hoogewijs
  • Jan Govaere
  • Cesare Galli
  • Emilie Vanhaesebrouck
  • Ann Van Soom
  • Silvia Colleoni
  • D Doenecke
  • Y Zhang
  • E Kardalinou
  • R Trappe
  • S Eick
  • H Erdjument-Bromage
  • P Tempst
  • R Iratni
  • M Hampsey
  • D Reinberg
  • Z W Sun
  • T Meergans
  • T Ohshige
  • S Takechi
  • T Nakayama
  • T W Du Clos
  • L Marnell
  • L T Zlock

Detail Information

Publications8

  1. ncbi Selection of reference genes for quantitative real-time PCR in equine in vivo and fresh and frozen-thawed in vitro blastocysts
    Katrien Smits
    Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    BMC Res Notes 2:246. 2009
    ..In this study a set of reliable reference genes was identified for equine in vivo and fresh and frozen-thawed in vitro embryos...
  2. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
    ..Thus we have defined the first reported CRP binding determinant on a protein...
  3. ncbi Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair
    T Ohshige
    Department of Biochemistry, Miyazaki Medical College, Japan
    Gene 131:193-9. 1993
    ..These findings, together with those reported previously on the H2A-V/H2B-II pair, suggest distinct manners of transcription regulation of different members of the chicken histone gene families, H2A and H2B...
  4. ncbi Characterization of the H1.5 gene completes the set of human H1 subtype genes
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitaet Goettingen, Germany
    Gene 184:141-8. 1997
    ..The H2B sequence shows no typical regulatory elements and no complete ORF, therefore we consider it as a pseudogene. The expression of the H1.5 gene was examined in several cell lines...
  5. ncbi SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
    Y Zhang
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School Piscataway, New Jersey 08854, USA
    Mol Cell 1:1021-31. 1998
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms...
  6. ncbi Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
    F Carrier
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Mol Cell Biol 19:1673-85. 1999
    ..Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins...
  7. ncbi The human H2A and H2B histone gene complement
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    Biol Chem 380:7-18. 1999
    ..The genes show varying expression patterns in different tumor cell lines...
  8. ncbi Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia Kzhyshkowska
    Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Biochem J 371:385-93. 2003
    ..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation...

Research Grants7

  1. RADIATION INDUCED RNA BINDING PROTEINS
    France Carrier; Fiscal Year: 2002
    ..We also plan to study the role of A-18, an independently isolated clone coding for a RBP induced by ultra-violet light, in the stress response. ..
  2. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2007
    ..This proposal will provide a better understanding of the basic mechanisms mediating this effect and will contribute to guide and develop mechanism-based therapeutics for cancer treatments. ..
  3. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2009
    ..This proposal will provide a better understanding of the basic mechanisms mediating this effect and will contribute to guide and develop mechanism-based therapeutics for cancer treatments. ..