Gene Symbol: HIST1H2AI
Description: histone cluster 1 H2A family member i
Alias: H2A/c, H2AFC, histone H2A type 1, H2A histone family, member C, H2A.1, histone 1, H2ai, histone H2A/ptl, histone cluster 1, H2ai
Species: human
Products:     HIST1H2AI

Top Publications

  1. Baranova S, Dmitrienok P, Ivanisenko N, Buneva V, Nevinsky G. Antibodies to H2a and H2b histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones. Mol Biosyst. 2017;13:1090-1101 pubmed publisher
    ..The third cluster corresponding to the H2a C-terminal part contains only five minor (†) sites of cleavage: 82-H†LQLAIRNDEELN†KLLG†RVâ..
  2. Nicassio F, Corrado N, Vissers J, Areces L, Bergink S, Marteijn J, et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007;17:1972-7 pubmed
    ..Together, our results implicate USP3 as a novel chromatin modifier in the maintenance of genome integrity. ..
  3. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  4. Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D. The human H2A and H2B histone gene complement. Biol Chem. 1999;380:7-18 pubmed
    ..The genes show varying expression patterns in different tumor cell lines. ..
  5. Boyne M, Pesavento J, Mizzen C, Kelleher N. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res. 2006;5:248-53 pubmed
    ..This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle. ..
  6. Jiang S, Liu Y, Xu C, Wang Y, Gong J, Shen Y, et al. Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library. G3 (Bethesda). 2017;7:3857-3866 pubmed publisher
    ..H2B N- and H2A C-termini were critical for maintaining nucleosome function and mutations in these regions led to pleiotropic ..
  7. Richly H, Rocha Viegas L, Ribeiro J, Demajo S, Gundem G, Lopez Bigas N, et al. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010;468:1124-8 pubmed publisher
    ..We provide here a model of the molecular mechanism of switching polycomb-repressed genes to an active state. ..
  8. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..
  9. Roussel L, Erard M, Cayrol C, Girard J. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 2008;9:1006-12 pubmed publisher
    ..In addition, the data provide, to the best of our knowledge, the first demonstration of the existence of non-histone cellular factors that bind to the acidic pocket of the nucleosome...