HIST1H2AG

Summary

Gene Symbol: HIST1H2AG
Description: histone cluster 1 H2A family member g
Alias: H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f, histone H2A type 1, H2A histone family, member P, H2A.1, histone 1, H2ag, histone H2A/p, histone H2A/ptl, histone cluster 1, H2ag
Species: human
Products:     HIST1H2AG

Top Publications

  1. Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W. The relative expression of human histone H2A genes is similar in different types of proliferating cells. DNA Cell Biol. 1994;13:161-70 pubmed
    ..These findings suggest that the relative expression of the individual members of a histone gene family is independent of the type of replicating cell. ..
  2. Boyne M, Pesavento J, Mizzen C, Kelleher N. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res. 2006;5:248-53 pubmed
    ..This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle. ..
  3. Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D. The human H2A and H2B histone gene complement. Biol Chem. 1999;380:7-18 pubmed
    ..The genes show varying expression patterns in different tumor cell lines. ..
  4. Ahn J, Gruen J. The genomic organization of the histone clusters on human 6p21.3. Mamm Genome. 1999;10:768-70 pubmed
  5. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  6. Nicassio F, Corrado N, Vissers J, Areces L, Bergink S, Marteijn J, et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007;17:1972-7 pubmed
    ..Together, our results implicate USP3 as a novel chromatin modifier in the maintenance of genome integrity. ..
  7. Richly H, Rocha Viegas L, Ribeiro J, Demajo S, Gundem G, Lopez Bigas N, et al. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010;468:1124-8 pubmed publisher
    ..We provide here a model of the molecular mechanism of switching polycomb-repressed genes to an active state. ..
  8. Soldi M, Bonaldi T. The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. Mol Cell Proteomics. 2013;12:764-80 pubmed publisher
    ..X and WICH, both enriched in silent domains. Chromatin proteomics expands the arsenal of tools for deciphering how all the distinct protein components act together to enforce a given region-specific chromatin status. ..
  9. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..

More Information

Publications12

  1. Roussel L, Erard M, Cayrol C, Girard J. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 2008;9:1006-12 pubmed publisher
    ..In addition, the data provide, to the best of our knowledge, the first demonstration of the existence of non-histone cellular factors that bind to the acidic pocket of the nucleosome...
  2. Shi J, Levinson D, Duan J, Sanders A, Zheng Y, Pe er I, et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009;460:753-7 pubmed publisher
    ..These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms. ..
  3. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..