HIRA

Summary

Gene Symbol: HIRA
Description: histone cell cycle regulator
Alias: DGCR1, TUP1, TUPLE1, protein HIRA, DiGeorge critical region gene 1, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1
Species: human
Products:     HIRA

Top Publications

  1. Tang Y, Poustovoitov M, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, et al. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006;13:921-9 pubmed
    Human HIRA, ASF1a, ASF1b and CAF-1 are evolutionally conserved histone chaperones that form multiple functionally distinct chromatin-assembly complexes, with roles linked to diverse nuclear process, such as DNA replication and formation ..
  2. Zhang R, Chen W, Adams P. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol. 2007;27:2343-58 pubmed
    ..Previously, we showed that a complex of histone chaperones, histone repressor A (HIRA) and antisilencing function 1a (ASF1a), plays a key role in the formation of SAHF...
  3. Lamour V, Lecluse Y, Desmaze C, Spector M, Bodescot M, Aurias A, et al. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. Hum Mol Genet. 1995;4:791-9 pubmed
    ..protein sequence, 1017 amino acids in length, entirely encompasses the 766 amino acids previously designated as TUPLE1. The completed protein has been renamed HIRA because it contains various features matching those found in HIR1 and ..
  4. Tagami H, Ray Gallet D, Almouzni G, Nakatani Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell. 2004;116:51-61 pubmed
    ..The H3.1 and H3.3 complexes contain distinct histone chaperones, CAF-1 and HIRA, that we show are necessary to mediate DNA-synthesis-dependent and -independent nucleosome assembly, respectively...
  5. Zhang R, Poustovoitov M, Ye X, Santos H, Chen W, Daganzo S, et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell. 2005;8:19-30 pubmed
    ..As cells approach senescence, a known chromatin regulator, HIRA, enters PML nuclear bodies, where it transiently colocalizes with HP1 proteins, prior to incorporation of HP1 ..
  6. Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, et al. Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol. 2007;27:2452-65 pubmed
    ..One of the earliest steps in the senescence program is translocation of a histone chaperone, HIRA, into promyelocytic leukemia (PML) nuclear bodies...
  7. Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, et al. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol. 2009;29:758-70 pubmed publisher
    ..Formation of SAHF in human cells is driven by a complex of histone chaperones, namely, HIRA and ASF1a. In yeast, the complex orthologous to HIRA/ASF1a contains two additional proteins, Hpc2p and Hir3p...
  8. Adamczyk M, Szatkowska R. Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment. PLoS ONE. 2017;12:e0185516 pubmed publisher
    ..Using chromatin immunoprecipitation (ChIP), we found an increased association of Rgt1 and Tup1 transcription factors with the highly activated HXT2 promoter in the rpc128-1007 strain...
  9. Ali A, Jadhav A, Jangid P, Patil R, Shelar A, Karuppayil S. The human muscarinic acetylcholine receptor antagonist, Dicyclomine targets signal transduction genes and inhibits the virulence factors in the human pathogen, Candida albicans. J Antibiot (Tokyo). 2018;71:456-466 pubmed publisher
    ..Eight genes were upregulated. Out of these, three major upregulated genes were Bcy1, Tup1, and Mig1...

More Information

Publications112 found, 100 shown here

  1. Meyer R, Algazeery A, Capri M, Brazier H, Ferry C, Aït Ahmed O. Drosophila Yemanuclein associates with the cohesin and synaptonemal complexes. J Cell Sci. 2014;127:4658-66 pubmed publisher
    ..3 chaperone in complex with Hira. We report here that Yem associates with the synaptonemal complex and the cohesin complex...
  2. Merhej J, Delaveau T, Guitard J, Palancade B, Hennequin C, Garcia M, et al. Yap7 is a transcriptional repressor of nitric oxide oxidase in yeasts, which arose from neofunctionalization after whole genome duplication. Mol Microbiol. 2015;96:951-72 pubmed publisher
    ..experiments and mutant analyses indicated that Yap7 represses YHB1 by recruiting the transcriptional repressor Tup1. In S...
  3. Lee K, Park S, Choi S, Park J. Proteus vulgaris and Proteus mirabilis Decrease Candida albicans Biofilm Formation by Suppressing Morphological Transition to Its Hyphal Form. Yonsei Med J. 2017;58:1135-1143 pubmed publisher
    ..was used to evaluate the expression of yeast-specific genes (rhd1 and rbe1), filament formation inhibiting genes (tup1 and nrg1), and hyphae-related genes (als3, ece1, hwp1, and sap5)...
  4. Asada R, Takemata N, Hoffman C, Ohta K, Hirota K. Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor. Mol Cell Biol. 2015;35:847-55 pubmed publisher
    ..Schizosaccharomyces pombe fission yeast Tup family corepressors Tup11 and Tup12 (Tup11/12), which are orthologs of Tup1 in Saccharomyces cerevisiae budding yeast and Groucho in Drosophila, negatively control chromatin and the ..
  5. Ando A, Suzuki C. Cooperative function of the CHD5-like protein Mdm39p with a P-type ATPase Spf1p in the maintenance of ER homeostasis in Saccharomyces cerevisiae. Mol Genet Genomics. 2005;273:497-506 pubmed
    ..Mutant alleles of five LWS genes (MDM39, RIC1, LAS21, TUP1 and BTS1) were recovered...
  6. Wang S, Xing Z, Pascuzzi P, Tran E. Metabolic Adaptation to Nutrients Involves Coregulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Corepressor in Saccharomyces cerevisiae. G3 (Bethesda). 2017;7:2235-2247 pubmed publisher
    ..genes in dbp2? to those of 700 other deletion strains from other studies, we find that CYC8 and TUP1, which form a complex and inhibit transcription of numerous genes, corepress a common set of genes with DBP2<..
  7. Sadasivam D, Huang D. Maintenance of Tissue Pluripotency by Epigenetic Factors Acting at Multiple Levels. PLoS Genet. 2016;12:e1005897 pubmed publisher
    ..experiments revealed that the active state of Hox genes is maintained substantially longer in mutants deficient for HIRA, a chaperone for the H3.3 variant. In addition, both HIRA and H3...
  8. Paul E, Zhu Z, Landsman D, Morse R. Genome-wide association of mediator and RNA polymerase II in wild-type and mediator mutant yeast. Mol Cell Biol. 2015;35:331-42 pubmed publisher
    ..strong and stable occupancy by Mediator have a wide range of activity and are enriched for targets of the Tup1-Cyc8 repressor complex...
  9. Nemet J, Vidan N, Sopta M. A meta-analysis reveals complex regulatory properties at Taf14-repressed genes. BMC Genomics. 2017;18:175 pubmed publisher
    ..Taken together our analyses suggest a novel role for Taf14 in repression and derepression of stress induced genes, most probably as part of a regulatory network which includes Cyc8-Tup1, Srb10 and histone modifying enzymes.
  10. Liu R, Shang Z, Li T, Yang M, Kong L. In Vitro Antibiofilm Activity of Eucarobustol E against Candida albicans. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Combined with the obvious elevation of negative regulator genes (TUP1, NRG1), we speculated that EE's inhibition of carbon flow to ergosterol triggered the mechanisms of the ..
  11. Lin S, Zheng X, Gu H, Li M. [Phenotypic and genotypic analysis of a fetus carrying an intermediate 22q11.2 deletion encompassing the CRKL gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:393-397 pubmed publisher
    ..21, which encompassed the CRKL gene but not TBX1, HIRA, COMT and MAPK1...
  12. Jöhnk B, Bayram Ö, Abelmann A, Heinekamp T, Mattern D, Brakhage A, et al. SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus. PLoS Pathog. 2016;12:e1005899 pubmed publisher
    ..Fbx15 binds SsnF/Ssn6 as part of the RcoA/Tup1-SsnF/Ssn6 co-repressor and is required for its correct nuclear localization...
  13. Dzikowska A, Grzelak A, Gawlik J, Szewczyk E, Mrozek P, Borsuk P, et al. KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans. Gene. 2015;573:310-20 pubmed publisher
    ..others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA(TUP1), which encodes the global transcriptional corepressor.
  14. Delaney K, Mailler J, Wenda J, Gabus C, Steiner F. Differential Expression of Histone H3.3 Genes and Their Role in Modulating Temperature Stress Response in Caenorhabditis elegans. Genetics. 2018;209:551-565 pubmed publisher
    ..However, we demonstrate an essential role for the conserved histone chaperone HIRA in the nucleosomal loading of all H3.3 variants. This requirement can be bypassed by mutation of the H3...
  15. Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, et al. Local potentiation of stress-responsive genes by upstream noncoding transcription. Nucleic Acids Res. 2016;44:5174-89 pubmed publisher
    ..We also found that upstream transcripts bind to the Groucho-Tup1 type transcriptional corepressors Tup11 and Tup12, and locally antagonize their repressive functions on Atf1 ..
  16. Olivares Yañez C, Emerson J, Kettenbach A, Loros J, Dunlap J, Larrondo L. Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa. Genetics. 2016;204:163-76 pubmed publisher
    ..in the latter process identified regulation of conidiation 1 (rco-1), the ortholog of the Saccharomyces cerevisiae Tup1 corepressor, as affecting period length...
  17. Suh J, Kim B, Yang Y, Suh D, Kim E. Cost effectiveness of influenza vaccination in patients with acute coronary syndrome in Korea. Vaccine. 2017;35:2811-2817 pubmed publisher
    ..indirect cost of MACEs in ACS patients using a probabilistic model and the Health Insurance Review and Assessment (HIRA)-National Patient Sample (NPS) database...
  18. Chiappini N, Cantisani R, Pancotto L, Ruggiero P, Rosa D, Manetti A, et al. Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro. PLoS ONE. 2015;10:e0129879 pubmed publisher
    ..In the present work, we used flow cytometry and confocal microscopy to identify and characterize human IRA (hIRA) B cells in tonsils...
  19. Abraham P, Maliekal T. Single cell biology beyond the era of antibodies: relevance, challenges, and promises in biomedical research. Cell Mol Life Sci. 2017;74:1177-1189 pubmed publisher
    ..It is postulated that intracellular molecular markers like nucleostemin (GNL3), alkaline phosphatase (ALPL) and HIRA can be used for improving the outcome of cardiac as well as bone regeneration...
  20. Choi E, Lee I, Je N. Inadequate stroke prevention in Korean atrial fibrillation patients in the post-warfarin era. Int J Cardiol. 2016;220:647-52 pubmed publisher
    ..2014 derived from the Aged Patient Sample (APS) compiled by the Health Insurance Review & Assessment Service (HIRA)...
  21. Fromental Ramain C, Ramain P, Hamiche A. The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation. Mol Cell Biol. 2017;37: pubmed publisher
    ..3 family, is mediated in mammals by distinct pathways involving either the histone regulator A (HIRA) complex or the death-associated protein (DAXX)/?-thalassemia X-linked mental retardation protein (ATRX) complex...
  22. Lee J, Kwon S, Chang J, Yuk J. Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter. Sci Rep. 2019;9:5410 pubmed publisher
    ..to 45 years extracted from the Korean Health Insurance Review & Assessment Service National Inpatient Sample (HIRA-NIS) 2009-2015. We used the RS model to extract diseases that were correlated with an endometriosis diagnosis...
  23. Oh J, Hyun J, Varshavsky A. Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway. Proc Natl Acad Sci U S A. 2017;114:E4370-E4379 pubmed publisher
    ..shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Δ cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself...
  24. Hope E, Amorosi C, Miller A, Dang K, Heil C, Dunham M. Experimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in Yeast. Genetics. 2017;206:1153-1167 pubmed publisher
    ..and, in an additional five clones, we recovered loss-of-function mutations in transcriptional repressor TUP1, which regulates FLO1 and other related genes...
  25. Youn H, Lee S, Han S, Kim L, Lee T, Oh M, et al. Obstetric risk factors for depression during the postpartum period in South Korea: a nationwide study. J Psychosom Res. 2017;102:15-20 pubmed publisher
    ..birth between January 1st, 2010 and December 31st, 2012 from the Health Insurance Review and Assessment service (HIRA) database. We analyzed the data using multivariable logistic regression models. A total of 17,483 (1...
  26. Kim J, Lee J, Lee J. Histone deacetylase-mediated morphological transition in Candida albicans. J Microbiol. 2015;53:805-11 pubmed publisher
    ..Various transcriptional factors such as Nrg1, Efg1, Brg1, Ssn6, and Tup1 are the key components of these signaling pathways. Since C...
  27. Moretto F, van Werven F. Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA. Curr Genet. 2017;63:325-329 pubmed publisher
    ..Finally, we provide evidence that IRT1 and IME1 are co-repressed by the Tup1-Cyc8 complex when nutrients are ample...
  28. Weidberg H, Moretto F, Spedale G, Amon A, van Werven F. Nutrient Control of Yeast Gametogenesis Is Mediated by TORC1, PKA and Energy Availability. PLoS Genet. 2016;12:e1006075 pubmed publisher
    ..Finally, we show that the transcriptional repressor Tup1 binds and represses the IME1 promoter when nutrients are ample, but is released from the IME1 promoter when both ..
  29. Bürglin T, Affolter M. Homeodomain proteins: an update. Chromosoma. 2016;125:497-521 pubmed publisher
    ..Homologs of the co-repressor protein Groucho are also present in plants (TOPLESS), where they have been shown to interact with small amphipathic motives (EAR), and in yeast (TUP1), where we find an EH1-like motif in MATα2.
  30. Kim J, Yoon S, Kim L, Kim D. Towards Actualizing the Value Potential of Korea Health Insurance Review and Assessment (HIRA) Data as a Resource for Health Research: Strengths, Limitations, Applications, and Strategies for Optimal Use of HIRA Data. J Korean Med Sci. 2017;32:718-728 pubmed publisher
    Health Insurance and Review Assessment (HIRA) in South Korea, also called National Health Insurance (NHI) data, is a repository of claims data collected in the process of reimbursing healthcare providers...
  31. Choi A, Shin J, Lee J, Lee Y, Kim M, Oh M, et al. Current practice and usual care of major cervical disorders in Korea: A cross-sectional study of Korean health insurance review and assessment service national patient sample data. Medicine (Baltimore). 2017;96:e8751 pubmed publisher
    ..This study examined Korean health insurance review and assessment service (HIRA) claims data to the aim of assessing prevalence and comparing current medical practice and costs of cervical ..
  32. Zhang K, Wang H, Rajput S, Folger J, Smith G. Characterization of H3.3 and HIRA expression and function in bovine early embryos. Mol Reprod Dev. 2017;: pubmed publisher
    ..The H3.3 exchange process is facilitated by the chaperone HIRA, particularly during zygote development. We previously demonstrated that H3...
  33. Maze I, Wenderski W, Noh K, Bagot R, Tzavaras N, Purushothaman I, et al. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015;87:77-94 pubmed publisher
    ..Here, we describe a novel mechanistic role for HIRA (histone cell cycle regulator) and proteasomal degradation-associated histone dynamics in the regulation of ..
  34. Park J, Kim M, Yoon S. Evaluation of Large-scale Data to Detect Irregularity in Payment for Medical Services. An Extended Use of Benford's Law. Methods Inf Med. 2016;55:284-91 pubmed publisher
    ..its applicability using actual large-scale healthcare data from Korea's Health Insurance Review and Assessment (HIRA) National Patient Sample (NPS)...
  35. Cho E, Lee N, Kim E, Kim S, Lee K, Park K, et al. Nurse staffing level and overtime associated with patient safety, quality of care, and care left undone in hospitals: A cross-sectional study. Int J Nurs Stud. 2016;60:263-71 pubmed publisher
    ..Facility data from the Health Insurance Review Agency (HIRA) were used to collect hospital characteristics...
  36. Córdova P, Alcaíno J, Bravo N, Barahona S, Sepulveda D, Fernández Lobato M, et al. Regulation of carotenogenesis in the red yeast Xanthophyllomyces dendrorhous: the role of the transcriptional co-repressor complex Cyc8-Tup1 involved in catabolic repression. Microb Cell Fact. 2016;15:193 pubmed
    ..transcriptional level and depends on the DNA-binding regulator Mig1, which recruits the co-repressor complex Cyc8-Tup1, which then represses the expression of target genes...
  37. Masuda R, Iguchi N, Tukuta K, Nagoshi T, Kemuriyama K, Muraguchi H. The Coprinopsis cinerea Tup1 homologue Cag1 is required for gill formation during fruiting body morphogenesis. Biol Open. 2016;5:1844-1852 pubmed publisher
    ..In this study, we found that the cag1 gene encodes a homologue of Saccharomyces cerevisiae Tup1. The C. cinerea genome contains another Tup1 homologue gene called Cc.tupA Reciprocal tagging of Cag1 and Cc...
  38. Ricketts M, Marmorstein R. A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function. J Mol Biol. 2017;429:1924-1933 pubmed publisher
    ..The human histone cell cycle regulator (HIRA) complex composed of HIRA, ubinuclein-1, CABIN1, and transiently anti-silencing function 1, forms one of the two ..
  39. Ricketts M, Frederick B, Hoff H, Tang Y, Schultz D, Singh Rai T, et al. Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex. Nat Commun. 2015;6:7711 pubmed publisher
    ..The HIRA histone chaperone complex, composed of HIRA, ubinuclein-1 (UBN1) and CABIN1, cooperates with the histone chaperone ..
  40. Yuk J, Shin J, Park W, Kim D, Shin J, Lee J. Association between pregnancy and adnexal torsion: A population-based, matched case-control study. Medicine (Baltimore). 2016;95:e3861 pubmed publisher
    ..case-control study using the Korean Health Insurance Review and Assessment Service-National Inpatients Sample (HIRA-NIS) from 2009 to 2011...
  41. CHURCH M, Smith K, Alhussain M, Pennings S, Fleming A. Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene. Nucleic Acids Res. 2017;45:4413-4430 pubmed publisher
    ..FLO1 transcription is regulated via the antagonistic activities of the Tup1-Cyc8 co-repressor and Swi-Snf co-activator complexes...
  42. Tanaka N, Mukai Y. Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes. Biochem Biophys Res Commun. 2015;468:32-8 pubmed publisher
    ..that the addition of tryptophan to Δcyc8 cultures partially restored cell growth, and the deletion of CYC8 and TUP1 reduced transcriptional levels of TAT1 and TAT2...
  43. Valenzuela N, Fan Q, Fa ak F, Soibam B, Nagandla H, Liu Y, et al. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016;9:335-45 pubmed publisher
    b>HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3...
  44. Zhang H, Han J, Kang B, Burgess R, Zhang Z. Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4. J Biol Chem. 2012;287:6573-81 pubmed publisher
    ..3-H4 are assembled via HIRA in a replication-independent pathway...
  45. Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, et al. Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity. Mol Cell. 2015;59:615-27 pubmed publisher
    ..Quantitative proteomic analysis reveals that the Ssn6 repeats affect its solubility and interactions with Tup1 and other regulators...
  46. Lim Y, Lee J, Bang S. Incidence, Survival and Prevalence Statistics of Classical Myeloproliferative Neoplasm in Korea. J Korean Med Sci. 2016;31:1579-85 pubmed publisher
    ..ET) using Korea National Cancer Incidence Database (KNCIDB) and Health Insurance Review and Assessment Service (HIRA) database. Between 2003 and 2011, a total of 4,342 new cases of MPN were reported to the KNCIDB...
  47. Duc C, Benoit M, Détourné G, Simon L, Poulet A, Jung M, et al. Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression. Plant Cell. 2017;29:1773-1793 pubmed publisher
    ..Their combination with mutants of the histone H3.3 chaperone HIRA (Histone Regulator A) results in impaired plant survival, suggesting that HIRA and ATRX function in complementary ..
  48. Lee K, Lee J, Kim J, Kim J, Ahn S, Kim J. Population-based outcomes research on treatment patterns and impact of chemotherapy in older patients with metastatic gastric cancer. J Cancer Res Clin Oncol. 2016;142:687-97 pubmed publisher
    ..Using the Korean Health Insurance Review and Assessment Service (HIRA) database, a nationwide population-based outcomes study was conducted...
  49. Uhrig J, Huang L, Barghahn S, Willmer M, Thurow C, Gatz C. CC-type glutaredoxins recruit the transcriptional co-repressor TOPLESS to TGA-dependent target promoters in Arabidopsis thaliana. Biochim Biophys Acta Gene Regul Mech. 2017;1860:218-226 pubmed publisher
    ..demonstrate that ROXYs interact with transcriptional co-repressors of the TOPLESS (TPL) family which are related to Tup1 in fungi and Groucho/TLE in animals...
  50. Serebruany V, Kim M, Cabrera Fuentes H, Lee K, Cho Y, Park K, et al. Mortality and cancer after 12 versus 30 months dual antiplatelet therapy. The Korean Outcomes Registry Evaluating Antithrombotics (KOREA). Thromb Haemost. 2017;117:934-939 pubmed publisher
    ..over 18 months follow-up in event-free patients at 12 months DAPT from the Health Insurance Review and Assessment (HIRA) dataset via the Korean Outcomes Registry Evaluating Antithrombotics (KOREA)...
  51. Park M, Bahk G. Estimate of the prevalence and burden of food poisoning by natural toxic compounds in South Korea. Food Res Int. 2015;78:108-113 pubmed publisher
    ..mycotoxins) during 2008-2012 in South Korea, using data from the Health Insurance Review and Assessment Service (HIRA), while accounting for uncertainty in the estimate...
  52. Lee J, Lee J, Kim J, Rhee C. Trend of cost and utilization of COPD medication in Korea. Int J Chron Obstruct Pulmon Dis. 2017;12:27-33 pubmed publisher
    ..Using the Korean Health Insurance Review and Assessment Service (HIRA) data from 2008 to 2013, COPD patients were identified...
  53. Jiang W, Nguyen A, Cao Y, Chang A, Reddel R. HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PLoS ONE. 2011;6:e17036 pubmed publisher
    ..Here we investigated the mechanism of HP1-mediated APB formation, and found that histone chaperones, HIRA and ASF1a, are present in APBs following activation of the p53/p21 pathway in ALT cells...
  54. Yang J, Choi J, Jang H, Park J, Han J, Youn H, et al. Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis. Biochem Biophys Res Commun. 2011;407:541-7 pubmed publisher
    Histone chaperones function in histone transfer and regulate the nucleosome occupancy and the activity of genes. HIRA is a replication-independent (RI) histone chaperone that is linked to transcription and various developmental processes...
  55. Rai T, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev N, et al. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol. 2011;31:4107-18 pubmed publisher
    The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially deposits the histone variant H3...
  56. Adam S, Polo S, Almouzni G. Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. Cell. 2013;155:94-106 pubmed publisher
    ..response to DNA damage in human cells, we identify a pathway involving the histone chaperone histone regulator A (HIRA) to promote transcription restart after UVC damage...
  57. Liu W, Li Y, Yuan H, Zhang B, Zhai S, Lu Y. WD40-REPEAT 5a functions in drought stress tolerance by regulating nitric oxide accumulation in Arabidopsis. Plant Cell Environ. 2017;40:543-552 pubmed publisher
    ..decreased NO accumulation and NOS-like activity when subjected to H2 O2 stress, we identified TUP1 as a novel regulator of NOS-like activity in yeast...
  58. Lee J, Zhang Z. O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. Proc Natl Acad Sci U S A. 2016;113:E3213-20 pubmed publisher
    The histone chaperone HIRA complex, consisting of histone cell cycle regulator (HIRA), Ubinuclein1 (UBN1), and calcineurin binding protein 1 (CABIN1), deposits histone variant H3...
  59. Ju Z, Wang H, Ma X, Ma D, Huang G. HIRA Gene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot. Chin Med J (Engl). 2016;129:2403-2408 pubmed publisher
    ..b>HIRA (histone cell cycle regulator) gene, as one of the candidate genes located at the critical region of 22q11DS, was ..
  60. Gocke C, Yu H, Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem. 2005;280:5004-12 pubmed
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms. ..
  61. Ahmad A, Kikuchi H, Takami Y, Nakayama T. Different roles of N-terminal and C-terminal halves of HIRA in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell growth. J Biol Chem. 2005;280:32090-100 pubmed
    We reported previously that chicken HIRA, a homolog of Saccharomyces cerevisiae transcriptional co-repressors Hir1p and Hir2p, possesses seven WD dipeptide motifs and an LXXLL motif in its N-terminal and C-terminal halves, respectively, ..
  62. Galvani A, Courbeyrette R, Agez M, Ochsenbein F, Mann C, Thuret J. In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells. Mol Cell Biol. 2008;28:3672-85 pubmed publisher
    ..in vitro with two other histone chaperones, chromatin assembly factor 1 (CAF-1) and histone repression A factor (HIRA), in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly...
  63. Goldberg A, Banaszynski L, Noh K, Lewis P, Elsaesser S, Stadler S, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678-91 pubmed publisher
    ..The H3.3 chaperone Hira is required for H3.3 enrichment at active and repressed genes...
  64. Ray Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, et al. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell. 2011;44:928-41 pubmed publisher
    ..Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA histone chaperones. Impairing replicative H3.1 incorporation via CAF-1 enables an alternative H3...
  65. Mahajan K, Fang B, Koomen J, Mahajan N. H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes. Nat Struct Mol Biol. 2012;19:930-7 pubmed publisher
    ..excluded binding of the transcriptional coactivator NPAT and RNA polymerase II and recruited the histone chaperone HIRA upstream of the Hist1 cluster...
  66. Pchelintsev N, McBryan T, Rai T, van Tuyn J, Ray Gallet D, Almouzni G, et al. Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Rep. 2013;3:1012-9 pubmed publisher
    The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner...
  67. Rai T, Cole J, Nelson D, Dikovskaya D, Faller W, Vizioli M, et al. HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes Dev. 2014;28:2712-25 pubmed publisher
    ..Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner...
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    ..In contrast, clustering is not disrupted by loss of the HIRA histone chaperone, despite high levels of expression, and in this background, mobilization frequency is only ..
  69. Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug J, et al. PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Res. 2017;27:913-921 pubmed publisher
    ..Loss of PML impairs deposition of H3.3 by ATRX and DAXX in PADs but preserves the H3.3 loading function of HIRA in these regions...
  70. Heo J, Chun M, Oh Y, Noh O, Kim L. Influenza Among Breast Cancer Survivors in South Korea: A Nationwide Population-Based Study. In Vivo. 2017;31:967-972 pubmed
    ..disease in breast cancer survivors using claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea...
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    ..This study analyzed the Health Insurance Review and Assessment Service (HIRA) database to assess asthma quality control in South Korea.
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    ..Within these sequences we have identified a gene expressed during human and murine embryogenesis. The gene, named TUPLE1, and its murine homologue, encodes a protein containing repeated motifs similar to the WD40 domains found in the ..
  73. Lorain S, Quivy J, Monier Gavelle F, Scamps C, Lecluse Y, Almouzni G, et al. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. Mol Cell Biol. 1998;18:5546-56 pubmed
    The human HIRA gene has been named after Hir1p and Hir2p, two corepressors which together appear to act on chromatin structure to control gene transcription in Saccharomyces cerevisiae...
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    b>HIRA maps to the DiGeorge/velocardiofacial syndrome critical region (DGCR) at 22q11 (refs 1,2) and encodes a WD40 repeat protein similar to yeast Hir1p and Hir2p...
  75. Delbarre E, Ivanauskiene K, Küntziger T, Collas P. DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. Genome Res. 2013;23:440-51 pubmed publisher
    ..DAXX is required for enrichment of ATRX, but not ASF1A or HIRA, with PML. Nonetheless, the chaperones colocalize with H3...
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    The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive...
  78. Kim J, Kwak S, Choe J, Kim S. The prevalence of Behçet's disease in Korea: data from Health Insurance Review and Assessment Service from 2011 to 2015. Clin Exp Rheumatol. 2017;35 Suppl 108:38-42 pubmed
    ..Behçet's disease (BD) from data in the Healthcare Bigdata Hub of the Health Insurance Review & Assessment (HIRA) Service from 2011 to 2015 in Korea...
  79. Sood V, Cajigas I, D Urso A, Light W, Brickner J. Epigenetic Transcriptional Memory of GAL Genes Depends on Growth in Glucose and the Tup1 Transcription Factor in Saccharomyces cerevisiae. Genetics. 2017;206:1895-1907 pubmed publisher
    ..Rather, downstream of Gal1, the Tup1 transcription factor and growth in glucose promote GAL transcriptional memory...
  80. Asada R, Umeda M, Adachi A, Senmatsu S, Abe T, Iwasaki H, et al. Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors. Nucleic Acids Res. 2017;45:9361-9371 pubmed publisher
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  82. Nakayama T, Nishioka K, Dong Y, Shimojima T, Hirose S. Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading. Genes Dev. 2007;21:552-61 pubmed
    ..The GAGA factor and FACT direct replacement of histone H3 by H3.3 through association of HIRA at this site, and maintain white expression under the heterochromatin environment...
  83. Cho H, Choi J, Kim Y, Son S, Lee K, Hwang H, et al. Prevalence and predictors of potentially inappropriate prescribing of central nervous system and psychotropic drugs among elderly patients: A national population study in Korea. Arch Gerontol Geriatr. 2018;74:1-8 pubmed publisher
    ..Ambulatory care visits were identified from the 2013 National Aged Patient Sample (HIRA-APS-2013) data, composed of 20% random samples of all enrollees in the universal health security program aged ?65 ..
  84. Choi M, Song J, Noh J, Yoon J, Lee S, Heo J, et al. Disease burden of hospitalized community-acquired pneumonia in South Korea: Analysis based on age and underlying medical conditions. Medicine (Baltimore). 2017;96:e8429 pubmed publisher
    ..hospitalized CAP in adults aged ?19 years and its epidemiologic trend using Health Insurance and Review Assessment (HIRA) data.This is a retrospective study using the HIRA database from year 2009 to 2013...
  85. Lin X, Yu A, Zhang C, Pi L, Bai X, Xiao D. Functional analysis of the global repressor Tup1 for maltose metabolism in Saccharomyces cerevisiae: different roles of the functional domains. Microb Cell Fact. 2017;16:194 pubmed publisher
    b>Tup1 is a general transcriptional repressor of diverse gene families coordinately controlled by glucose repression, mating type, and other mechanisms in Saccharomyces cerevisiae...
  86. Sitbon D, Podsypanina K, Yadav T, Almouzni G. Shaping Chromatin in the Nucleus: The Bricks and the Architects. Cold Spring Harb Symp Quant Biol. 2017;: pubmed publisher
    ..We highlight how a fine-tuned assembly line of bricks (H3.3 and CENP-A) and architects (HIRA, HJURP, and DAXX) is key in adaptation to developmental and pathological changes...
  87. Park Y, Kim J, Lee B, Kim T, Lee E. Annual prevalence and economic burden of genital warts in Korea: Health Insurance Review and Assessment (HIRA) service data from 2007 to 2015. Epidemiol Infect. 2017;:1-10 pubmed publisher
    ..Referring to the increasing AGW prevalence and its disease burden, active HPV infection control surveillance and prevention in males are worth consideration...
  88. Lorain S, Demczuk S, Lamour V, Toth S, Aurias A, Roe B, et al. Structural Organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22. Genome Res. 1996;6:43-50 pubmed
    The human gene HIRA lies within the smallest critical region for the DiGeorge syndrome (DGS), a haploinsufficiency developmental disorder associated with instertitial deletions in most patients in a juxtacentromeric region of chromosome ..
  89. Wu J, Suka N, Carlson M, Grunstein M. TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast. Mol Cell. 2001;7:117-26 pubmed
    b>TUP1 is recruited to and represses genes that regulate mating, glucose and oxygen use, stress response, and DNA damage...
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    ..five amino acids, is assembled into nucleosomes, along with histone H4, at genic regions by the histone chaperone HIRA, whereas H3.1 is assembled into nucleosomes in a CAF-1-dependent reaction...