Gene Symbol: HINT1
Description: histidine triad nucleotide binding protein 1
Alias: HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide-binding protein 1, adenosine 5'-monophosphoramidase, protein kinase C inhibitor 1, protein kinase C-interacting protein 1
Species: human
Products:     HINT1

Top Publications

  1. Lima C, Klein M, Hendrickson W. Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science. 1997;278:286-90 pubmed
    ..The approach described here may be useful in identifying structure-function relations between protein families identified through genomics. ..
  2. Bieganowski P, Garrison P, Hodawadekar S, Faye G, Barnes L, Brenner C. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem. 2002;277:10852-60 pubmed publisher
    ..triad superfamily of nucleotide hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch of Fhit-related hydrolases, and a branch of galactose-1-phosphate uridylyltransferase (GalT)..
  3. Brenner C. Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry. 2002;41:9003-14 pubmed
    ..of sequence, substrate specificity, structure, evolution, and mechanism, HIT proteins can be classified into the Hint branch, which consists of adenosine 5'-monophosphoramide hydrolases, the Fhit branch, which consists of diadenosine ..
  4. Chou T, Sham Y, Wagner C. Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. Biochemistry. 2007;46:13074-9 pubmed
    ..coli or human lysyl-tRNA synthetase were partially transferable by C-terminal loop exchange. Hence, our results support the critical role of the C-terminal loop of human and E. coli Hint1 on governing substrate specificity.
  5. Ray R, Jepson C, Wileyto E, Dahl J, Patterson F, Rukstalis M, et al. Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial. Nicotine Tob Res. 2007;9:1237-41 pubmed
    ..the role of genetic variants in two genes encoding mu-opioid-receptor-interacting proteins, namely ARRB2 and HINT1. Participants were 374 smokers treated for nicotine dependence with either transdermal nicotine or nicotine nasal ..
  6. Wang L, Li H, Zhang Y, Santella R, Weinstein I. HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. Int J Cancer. 2009;124:1526-34 pubmed publisher
    ..The human hepatoma cell lines Hep3B and HepG2 express very low levels of the HINT1 protein but the Huh7 cells express a relatively high level...
  7. Weiske J, Huber O. The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. J Biol Chem. 2006;281:27356-66 pubmed
    b>Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+/- and Hint-/- mouse models...
  8. Chou T, Tikh I, Horta B, Ghosh B, de Alencastro R, Wagner C. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. J Biol Chem. 2007;282:15137-47 pubmed
    b>Hint1 is a homodimeric protein and member of the ubiquitous HIT superfamily. Hint1 catalyzes the hydrolysis of purine phosphoramidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS)...
  9. Ge L, Zhu M, Yang J, Wang F, Zhang R, Zhang J, et al. Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression. Pharmacol Biochem Behav. 2015;131:77-86 pubmed publisher
    ..kinase isoenzyme 1 (AK1), nucleoside diphosphate kinase B (NDKB), histidine triad nucleotide-binding protein 1 (HINT1), acyl-protein thioesterase 2 (APT-2), and glutathione S-transferase A4 (GSTA4)...

More Information

Publications133 found, 100 shown here

  1. Ghosh A, Saini S, Das S, Mandal A, Sardar A, Ansari M, et al. Glucose-6-phosphate dehydrogenase and Trypanothione reductase interaction protects Leishmania donovani from metalloid mediated oxidative stress. Free Radic Biol Med. 2017;106:10-23 pubmed publisher
    ..was severely impaired by addition of SbIII, AsIII and TeIV extraneously, which hint towards metalloid driven structural changes of the interacting proteins...
  2. Martin J, Balmer M, Rajendran S, Maurhofer O, Dufour J, St Pierre M. Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am J Physiol Gastrointest Liver Physiol. 2016;310:G497-509 pubmed publisher
    ..HFD-treated Hint2(-/-) livers showed more steatosis, and plasma insulin and cholesterol were higher than in Hint(+/+) mice...
  3. Tsai R, Boxer A. Treatment of frontotemporal dementia. Curr Treat Options Neurol. 2014;16:319 pubmed publisher
    ..For behavioral symptoms, selective serotonin reuptake inhibitors may be effective, while case reports hint at possible efficacy with antipsychotics or anti-epileptics, but use of these latter agents is limited due to ..
  4. Furman P, Murakami E, Niu C, Lam A, Espiritu C, Bansal S, et al. Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661. Antiviral Res. 2011;91:120-32 pubmed publisher
    ..Histidine triad nucleotide-binding protein 1 (Hint 1) then removes the amino acid moiety, which is followed by hydrolysis of the methoxyl group at the O(6)-position ..
  5. Saluk J, Banos A, Hopkinson W, Rees H, Syed D, Hoppensteadt D, et al. Prevalence of metabolic syndrome in patients undergoing total joint arthroplasty and relevance of biomarkers. Int Angiol. 2017;36:136-144 pubmed publisher
    ..Insulin and c-peptide patterns among the different test groups hint toward a complex and dysfunctional metabolic process involved, with leptin and underlying insulin resistance ..
  6. Hipp K, Schäfer B, Kepp G, Jeske H. Properties of African Cassava Mosaic Virus Capsid Protein Expressed in Fission Yeast. Viruses. 2016;8: pubmed publisher
    ..In DNA binding assays, supernatant CP accelerated the migration of ssDNA in agarose gels, which is a first hint for particle formation...
  7. Hahn J, Supp D. Abnormal expression of the vitamin D receptor in keloid scars. Burns. 2017;43:1506-1515 pubmed publisher
    ..The results suggest that VDR may play a role in keloid pathology, and hint at a possible role for VDR in the increased susceptibility to keloid scarring in individuals with darkly pigmented ..
  8. Maccioni R, Setzu M, Talani G, Solari P, Kasture A, Sucic S, et al. Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS. Sci Rep. 2018;8:16002 pubmed publisher
    ..Hence, given the involvement of some potassium channels in the effects of anaesthetics, our results also hint toward a possible dysregulation of some potassium channels in the ALS-TDP-43 Drosophila model, that might shed new ..
  9. Ahmad S, Basak T, Anand Kumar K, Bhardwaj G, Lalitha A, Yadav D, et al. Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. J Proteomics. 2015;127:178-84 pubmed publisher
    ..Our results hint towards a larger effect of vitamin B12 deficiency compared to that of folate presumably due to greater elevation of ..
  10. Mayerhofer R, Fröhlich E, Reichmann F, Farzi A, Kogelnik N, Fröhlich E, et al. Diverse action of lipoteichoic acid and lipopolysaccharide on neuroinflammation, blood-brain barrier disruption, and anxiety in mice. Brain Behav Immun. 2017;60:174-187 pubmed publisher
    ..The results obtained with an LTA preparation contaminated with LPS hint at a facilitatory interaction between TLR2 and TLR4, the adverse impact of which on long-term neuroinflammation, ..
  11. Kendall A, Pilkington S, Massey K, Sassano G, Rhodes L, Nicolaou A. Distribution of bioactive lipid mediators in human skin. J Invest Dermatol. 2015;135:1510-1520 pubmed publisher
    ..demonstrate the diversity of lipid mediators involved in maintaining tissue homeostasis in resting skin and hint at their contribution to signaling, cross-support, and functions of different skin compartments...
  12. Benleulmi Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit M, et al. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016;60:95-108 pubmed publisher
    ..In conclusion, we show that MT1 is part of the presynaptic protein network and negatively regulates Cav 2.2 activity, providing a first hint for potential synaptic functions of MT1.
  13. Zhang X, Xia Q, Wei R, Song H, Mi J, Lin Z, et al. Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free Radic Biol Med. 2019;: pubmed publisher
    ..pineal gland hormone melatonin effectively protects spermatogonia from the stress of chemotherapy and oxidation and reveals the underlying molecular mechanisms, which will provide an important hint for fertility protection in clinic.
  14. Dong W, Zhang H, Wang R, Pan H. Molecular cloning, antiserum preparation and expression analysis during head regeneration of α-crystallin type heat shock protein in Hydra vulgaris. J Genet. 2018;97:911-924 pubmed
    ..vulgaris. In conclusion, our results gave the hint that α-Hsp could be related to wound healing and tissue remodelling at early regeneration stages, and may ..
  15. Chu N, Clarke S, Timberlake S, Polz M, Grossman A, Alm E. A Mobile Element in mutS Drives Hypermutation in a Marine Vibrio. MBio. 2017;8: pubmed publisher
    ..Our findings reveal a novel mechanism by which one bacterium alters its mutation rate and hint at a possible evolutionary role for mobile elements within mutS in other bacteria...
  16. Lin J, Wang R, Chen J. Tigecycline-induced acute pancreatitis in a renal transplant patient: a case report and literature review. BMC Infect Dis. 2018;18:201 pubmed publisher
    ..These facts were sufficient to hint that pancreatitis was slowly becoming prominent...
  17. Zhou W, Liu G, Yang S, Mi B, Ye S. Low-intensity treadmill exercise promotes rat dorsal wound healing. J Huazhong Univ Sci Technolog Med Sci. 2016;36:121-126 pubmed publisher
    ..The present work may provide some hint for future study of treating refractory wound.
  18. Zheng W, Kou Y, Gao F, Ouyang X. Enzymatic changes in myosin regulatory proteins may explain vasoplegia in terminally ill patients with sepsis. Biosci Rep. 2016;36: pubmed publisher
    ..The results of our study provide indirect hint that control of inflammation is a major therapeutic approach in sepsis, and may facilitate to ameliorate the ..
  19. Hale V, Chen J, Johnson S, Harrington S, Yab T, Smyrk T, et al. Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Cancer Epidemiol Biomarkers Prev. 2017;26:85-94 pubmed publisher
    ..These data hint that increased sugar, protein, and lipid metabolism along with increased bile acid production could promote a ..
  20. Weckmann M, Becker T, Nissen G, Pech M, Kopp M. SiMA: A simplified migration assay for analyzing neutrophil migration. Cytometry A. 2017;91:675-685 pubmed publisher
    ..Additionally, a comparison of four asthmatic and three non-asthmatic patients gives a first hint to the capability of SiMA assay in the context of migration based diagnostics...
  21. Srinivas S, Cronan J. An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine. J Bacteriol. 2017;199: pubmed publisher
    ..These observations provide insights into the structural dynamics of FabG and hint at yet another point of regulation between fatty acid and lipid A biosynthesis...
  22. Obschonka M, Stuetzer M, Rentfrow P, Shaw Taylor L, Satchell M, Silbereisen R, et al. In the shadow of coal: How large-scale industries contributed to present-day regional differences in personality and well-being. J Pers Soc Psychol. 2018;115:903-927 pubmed publisher
    ..Further analyses focusing on mechanisms hint at the roles of selective migration and persisting economic hardship. Finally, a robustness check in the U.S...
  23. Caiola E, Falcetta F, Giordano S, Marabese M, Garassino M, Broggini M, et al. Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach. J Exp Clin Cancer Res. 2018;37:302 pubmed publisher
    ..Our results hint at the possibility that energy stress induced by calorie restriction regimens may sensitize NSCLCs with these co-..
  24. Fathi Z, Syn N, Zhou J, Roudi R. Molecular epidemiology of lung cancer in Iran: implications for drug development and cancer prevention. J Hum Genet. 2018;63:783-794 pubmed publisher
    ..of research performed in Iran has revealed a dearth of studies in topics, which are otherwise highly pursued in developed countries, but nevertheless, has begun to hint at a distinct biology of lung cancer in this part of the world.
  25. Matot I, Nachmansson N, Duev O, Schulz S, Schroeder Stein K, Frede S, et al. Impaired liver regeneration after hepatectomy and bleeding is associated with a shift from hepatocyte proliferation to hypertrophy. FASEB J. 2017;31:5283-5295 pubmed publisher
    ..The results hint at specific pathways to target in order to improve liver regeneration during PHx and bleeding.-Matot, I...
  26. Lee S, Meyer M, Benkusky N, O Brien C, Pike J. Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells. J Biol Chem. 2015;290:30573-86 pubmed publisher
    ..These studies define mechanisms associated with hormonal regulation of the Vdr and hint at the differential nature of VDR binding activity at the Vdr gene in different primary target tissues in vivo.
  27. Zhao X, Zhang K, Daniel P, Wisbrun N, Fuchs H, Fan H. Delayed allogeneic skin graft rejection in CD26-deficient mice. Cell Mol Immunol. 2018;: pubmed publisher
    ..These results indicate that CD26 is involved in allogeneic skin graft rejection and provides another hint that CD26 deficiency leads to less rejection due to lower activation and proliferation of host immune cells.
  28. Maier G, Rapp M, Waite J, Israelachvili J, Butler A. BIOLOGICAL ADHESIVES. Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement. Science. 2015;349:628-32 pubmed publisher
    ..Notably, the abundance and proximity of catecholic Dopa (3,4-dihydroxyphenylalanine) and lysine residues hint at a synergistic interplay in adhesion...
  29. Jin W, Woo D, Jahng G. In vivo H1 MR spectroscopy using 3 Tesla to investigate the metabolic profiles of joint fluids in different types of knee diseases. J Appl Clin Med Phys. 2016;17:561-572 pubmed publisher
    ..the three types of diseases, the different lipid metabolite peaks and their ratios in the three disease groups may give us a hint at the different mechanisms of joint fluids in the infectious, degenerative, and traumatic diseases.
  30. Hsu K, Tseng J, Wang C, Yang T, Tseng C, Chen H, et al. Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients. Oncotarget. 2016;7:53299-53308 pubmed publisher
    ..These phenomena may hint at the direction of future research into lung carcinogenesis and EGFR mutagenesis.
  31. Xu X, Hui E, Mok M, Jian J, Lau C, Mak H. Structural Brain Network Reorganization in Patients with Neuropsychiatric Systemic Lupus Erythematosus. AJNR Am J Neuroradiol. 2017;38:64-70 pubmed publisher
    ..046) and middle temporal gyrus (P = .041). Our results hint at a plausible relationship between the neuropsychiatric symptoms and reorganization of the structural brain ..
  32. Mall E, Herrmann D, Niemann H. Murine pluripotent stem cells with a homozygous knockout of Foxg1 show reduced differentiation towards cortical progenitors in vitro. Stem Cell Res. 2017;25:50-60 pubmed publisher
    ..This study is a first hint that this differentiation method can be used to analyze even extreme phenotypes that are lethal in vivo.
  33. Reich U, Warnecke A, Szczepek A, Mazurek B, Olze H. Establishment of an experimental system to study the influence of electrical field on cochlear structures. Neurosci Lett. 2015;599:38-42 pubmed publisher
    ..Although performed with immature auditory tissues, our findings hint at the possibility of particular electric current inducing damage or loss of auditory hair cells, which should be ..
  34. Gonzalez Gutierrez G, Grosman C. The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold. J Gen Physiol. 2015;146:15-36 pubmed publisher
    ..be exercised when generalizing results obtained with ELIC to the rest of the pLGICs, but more intriguingly, they hint at the possibility that ELIC is a representative of a novel branch of the superfamily with markedly divergent pore ..
  35. Sedda T, Baralla E, Varoni M, Pasciu V, Lorenzoni G, Demontis M. Determination of microcystin-LR in clams (Tapes decussatus) of two Sardinian coastal ponds (Italy). Mar Pollut Bull. 2016;108:317-20 pubmed publisher
    ..According to the tolerable daily intake suggested by the World Health Organization, these results hint that clams harvested in these ponds are safe for human health...
  36. Wu X, Bao T, Ke Y, Sun D, Shi Z, Tang H, et al. Hint1 suppresses migration and invasion of hepatocellular carcinoma cells in vitro by modulating girdin activity. Tumour Biol. 2016;37:14711-14719 pubmed
    Histidine triad nucleotide-binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene. Its role in cancer cell migration has not been previously speculated...
  37. Armitage D. Bacteria facilitate prey retention by the pitcher plant Darlingtonia californica. Biol Lett. 2016;12: pubmed
    ..These properties facilitated the retention of insects by both fluids and hint at a previously undescribed class of plant-microbe interaction.
  38. Burn T, Alvarez J. Reverse transendothelial cell migration in inflammation: to help or to hinder?. Cell Mol Life Sci. 2017;74:1871-1881 pubmed publisher
    ..interstitial migration within tissues, with particular emphasis on some of the more recent studies that finally hint at potential mechanisms...
  39. Shah R, Chou T, Maize K, Strom A, Finzel B, Wagner C. Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain. Biochem Biophys Res Commun. 2017;491:760-766 pubmed publisher
    Human histidine triad nucleotide binding protein 1 (hHint1) is a purine nucleoside phosphoramidase and adenylate hydrolase that has emerged as a potential therapeutic target for the management of pain...
  40. Iwai H, Mikula K, Oeemig J, Zhou D, Li M, Wlodawer A. Structural Basis for the Persistence of Homing Endonucleases in Transcription Factor IIB Inteins. J Mol Biol. 2017;429:3942-3956 pubmed publisher
    ..Some inteins contain a homing endonuclease (HEN) responsible for their propagation. Hedgehog/INTein (HINT) domains catalyzing protein splicing and their nested HEN domains are thought to be functionally independent ..
  41. He J, Yu Y, Xiong Y, Hashikawa T, Chan Y. Modulatory effect of cortical activation on the lemniscal auditory thalamus of the Guinea pig. J Neurophysiol. 2002;88:1040-50 pubmed
    ..of the corticofugal modulatory effects on the MGv of the guinea pig and the cat, together with anatomical findings, hint that the strong facilitatory effect is generated through the strong corticothalamic direct connection and that the ..
  42. Veazey K, Parnell S, Miranda R, Golding M. Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. Epigenetics Chromatin. 2015;8:39 pubmed publisher
    ..suggest that the immediate and long-term impacts of alcohol exposure on chromatin structure are distinct, and hint at the existence of a possible coordinated epigenetic response to ethanol during development...
  43. Günther S, Ostheimer C, Stangl S, Specht H, Mózes P, Jesinghaus M, et al. Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Front Immunol. 2015;6:556 pubmed publisher
    ..These data might provide a first hint that squamous cell NSCLC is more immunogenic than adeno NSCLC.
  44. Saeloh D, Tipmanee V, Voravuthikunchai S. Rhodomyrtone Target Exploration: Computer Aided Search on Staphylococcus aureus Key Proteins as a Potential Therapeutic Target. Curr Comput Aided Drug Des. 2016;12:119-34 pubmed
    ..In addition, checkerboard assay and cell visualization gave a hint on target confirmation. We have proposed potential rhodomyrtone targets, and DHFR and FtsZ caught our interest...
  45. Lalonde R, Moses D, Zhang J, Cornell N, Ekker M, Akimenko M. Differential actinodin1 regulation in zebrafish and mouse appendages. Dev Biol. 2016;417:91-103 pubmed publisher
    ..Altogether these results hint for a change in regulation of and1 during evolution that led to the downregulation and eventual loss of this gene ..
  46. Böker A, Kuczyk M, Kramer M, Merseburger A, Krüger K, Imkamp F, et al. True Incidence of Gleason 6 Pathology in Patients with Metastatic Castration Resistant Prostate Cancer (mCRPC). Adv Ther. 2017;34:171-179 pubmed publisher
    Recent evidence from histology studies regarding random prostate biopsies hint toward a relationship between higher biopsy Gleason score and the development of metastatic castration resistant prostate cancer (mCRPC)...
  47. Kubricht J, Lu H, Holyoak K. Individual differences in spontaneous analogical transfer. Mem Cognit. 2017;45:576-588 pubmed publisher
    ..analog when solving a target problem, although they are able to form mappings and derive inferences when given a hint to recall the source...
  48. Hefter H, Rosenthal D. Improvement of upper trunk posture during walking in hemiplegic patients after injections of botulinum toxin into the arm. Clin Biomech (Bristol, Avon). 2017;43:15-22 pubmed publisher
    ..and posture after injections of botulinum toxin into the affected arm would be at variance with this hypothesis and hint towards a multifactorial trunk control deficit...
  49. Macleod M, Nersessian N. Modeling complexity: cognitive constraints and computational model-building in integrative systems biology. Hist Philos Life Sci. 2018;40:17 pubmed publisher
    ..Problem solving depends as ever on human cognitive resources. Current philosophical accounts hint at their importance, but it remains to be understood what roles human cognition plays in computational modeling...
  50. Liu G, Liu Y, Jiang G, Ren W. The reversal effect of Ginsenoside Rh2 on drug resistance in human colorectal carcinoma cells and its mechanism. Hum Cell. 2018;31:189-198 pubmed publisher
    Recent studies hint that Ginsenoside is involved in cancer prevention and treatment. In this study, we investigated the effect of Ginsenoside Rh2 on drug resistance in human colorectal carcinoma (CRC) cells and its mechanism...
  51. Graubert T, Payton M, Shao J, Walgren R, Monahan R, Frater J, et al. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. PLoS ONE. 2009;4:e4583 pubmed publisher
    ..2 genes are not common events in MDS, and implicate haploinsufficiency of multiple genes as the relevant genetic consequence of this common deletion. ..
  52. Čokić V, Mojsilović S, Jauković A, Kraguljac Kurtović N, Mojsilović S, Šefer D, et al. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Blood Cells Mol Dis. 2015;55:373-81 pubmed publisher
    ..The 41 and 39 genes were significantly upregulated in CML CD34(+) cells (HINT1, TXN, SERBP1) and granulocytes, respectively...
  53. Rao A, Rishiq D, Yu L, Zhang Y, Abrams H. Neural Correlates of Selective Attention With Hearing Aid Use Followed by ReadMyQuips Auditory Training Program. Ear Hear. 2017;38:28-41 pubmed
    ..Cortical late event-related potentials (ERPs) and the Hearing in Noise Test (HINT) were administered at prefitting, pretraining, and post-training to assess effects of hearing aid use and RMQ ..
  54. Zenz J, Zenz M. Survey on German Palliative Care Specialists' Experiences with Advance Directives. Pain Ther. 2017;6:17-28 pubmed publisher
    ..4%). The wish for hospice treatment (44.8%) or spiritual care (39.3%) was less frequent. The results hint at fears and deficits in the care of patients at the end of life...
  55. Llames M, Huber P, Metz S, Unrein F. Interplay between stochastic and deterministic processes in the maintenance of alternative community states in Verrucomicrobia-dominated shallow lakes. FEMS Microbiol Ecol. 2017;93: pubmed publisher
    ..Altogether, these results hint to a divergence in function among these alternative communities, mediated by major shifts in bacterial community ..
  56. Rübben A, Araujo A. Cancer heterogeneity: converting a limitation into a source of biologic information. J Transl Med. 2017;15:190 pubmed publisher
    ..Identification of parallel evolution by analyzing spatial heterogeneity may hint to driver mutations which might represent additional therapeutic targets besides driver mutations present in a ..
  57. Rodríguez Muñoz M, Sánchez Blázquez P, Callado L, Meana J, Garzón Niño J. Schizophrenia and depression, two poles of endocannabinoid system deregulation. Transl Psychiatry. 2017;7:1291 pubmed publisher
    ..Thus, the levels of HINT1 proteins and NMDAR NR1 subunits carrying the C1 cytosolic segment were increased in depressives and decreased in ..
  58. Konowałek Ł, Wolanczyk T. Changes in Emotional and Behavioral Problems Between 2000 and 2011 Among 16-Year-Old Polish Children: A Cross-Sectional Study. Child Psychiatry Hum Dev. 2018;49:757-765 pubmed publisher
    ..Social and thought problems also rose significantly. Gender related time trends hint at a male increase in externalizing, aggressive behaviors and anxiety/depression...
  59. Parmar C, Barry J, Hosny A, Quackenbush J, Aerts H. Data Analysis Strategies in Medical Imaging. Clin Cancer Res. 2018;24:3492-3499 pubmed publisher
    ..Precedents in radiology as well as a wealth of research studies hint at the clinical relevance of these characteristics...
  60. Weitzdoerfer R, Stolzlechner D, Dierssen M, Ferreres J, Fountoulakis M, Lubec G. Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain. J Neural Transm Suppl. 2001;:347-59 pubmed
    ..These results may help to understand the abundant mechanisms leading to abnormalities in the wiring, structure and function of DS brain. ..
  61. Mushenheim P, Trivedi R, Roy S, Arnold M, Weibel D, Abbott N. Effects of confinement, surface-induced orientations and strain on dynamical behaviors of bacteria in thin liquid crystalline films. Soft Matter. 2015;11:6821-31 pubmed publisher
    ..Overall, these results provide new insight into the influence of surface-oriented LCs on dynamical bacterial behaviors and hint at novel ways to manipulate bacteria using confined LC phases that are not possible in isotropic solutions.
  62. Bukusoglu E, Bedolla Pantoja M, Mushenheim P, Wang X, Abbott N. Design of Responsive and Active (Soft) Materials Using Liquid Crystals. Annu Rev Chem Biomol Eng. 2016;7:163-96 pubmed publisher
    ..Ongoing efforts hint also that the collective properties of LCs (e.g...
  63. Marriott A, Vasieva O, Fang Y, Copeland N, McLennan A, Jones N. NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes. PLoS ONE. 2016;11:e0154674 pubmed publisher
    ..Potential mechanisms for gene regulation mediated by Ap4A and/or NUDT2 disruption include binding of Ap4A to the HINT1 co-repressor, autocrine activation of purinoceptors by Ap4A, chromatin remodeling, effects of NUDT2 loss on ..
  64. Zhang X, Zhu Y, Zhu X, Chen J, Shi H, Shi D, et al. ORF3a deletion in field strains of porcine-transmissible gastroenteritis virus in China: A hint of association with porcine respiratory coronavirus. Transbound Emerg Dis. 2017;64:698-702 pubmed publisher
    ..The results of the present study thus provide important information regarding the underlying evolution mechanisms of coronaviruses. ..
  65. Tripathi B, Das R, Mukherjee A, Mutsuddi M. Interaction of Spoonbill with Prospero in Drosophila: Implications in neuroblast development. Genesis. 2017;55: pubmed publisher
    Identification of Spoon as a suppressor of SCA8 associated neurodegeneration provides us a hint about its role in neuronal development and maintenance. However, a detailed molecular characterization of spoon has not yet been reported...
  66. Taherkhani M, Mahjoub S, Moslemi D, Karkhah A. Three cycles of AC chemotherapy regimen increased oxidative stress in breast cancer patients: A clinical hint. Caspian J Intern Med. 2017;8:264-268 pubmed publisher
    ..Also, in this study the effect of age and the stage of disease on oxidative stress markers were compared and evaluated...
  67. Wang Y, Liu Y, Zhang M, Lv L, Zhang X, Zhang P, et al. LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation. Stem Cell Res Ther. 2018;9:65 pubmed publisher
    ..Taken together, our findings reveal that LRRC15 is an essential regulator for osteogenesis of MSCs through modulating p65 cytoplasmic/nuclear translocation, and give a novel hint for MSC-mediated bone regeneration.
  68. Crivelli D, Sabogal Rueda M, Balconi M. Linguistic and motor representations of everyday complex actions: an fNIRS investigation. Brain Struct Funct. 2018;223:2989-2997 pubmed publisher
    ..Such first pieces of evidence hint at potential implications for novel procedures for rehabilitation of movement and action deficits.
  69. Peeters K, Chamova T, Tournev I, Jordanova A. Axonal neuropathy with neuromyotonia: there is a HINT. Brain. 2017;140:868-877 pubmed publisher
    Recessive mutations in the gene encoding the histidine triad nucleotide binding protein 1 (HINT1) were recently shown to cause a motor-predominant Charcot-Marie-Tooth neuropathy...
  70. Criscenti G, Vasilevich A, Longoni A, De Maria C, Van Blitterswijk C, Truckenmüller R, et al. 3D screening device for the evaluation of cell response to different electrospun microtopographies. Acta Biomater. 2017;55:310-322 pubmed publisher
    ..organization with a close correspondence to the patterns, as shown by phenoplot and boxplot analysis, and might hint at the differential activity of cell signaling...
  71. Plümper O, King H, Geisler T, Liu Y, Pabst S, Savov I, et al. Subduction zone forearc serpentinites as incubators for deep microbial life. Proc Natl Acad Sci U S A. 2017;114:4324-4329 pubmed publisher
    ..signatures identified in the clasts and those of bacteria-derived biopolymers from other serpentinizing systems hint at the possibility of deep microbial life within the forearc...
  72. Lodola F, Laforenza U, Cattaneo F, Ruffinatti F, Poletto V, Massa M, et al. VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells. Oncotarget. 2017;8:95223-95246 pubmed publisher
    ..demonstrate for the first time that BC-ECFCs are insensitive to VEGF, which might explain at cellular and molecular levels the failure of anti-VEGF therapies in BC patients, and hint at SOCE as a novel molecular target for this disease.
  73. Klein M, Yao Y, Slosberg E, Lima C, Doki Y, Weinstein I. Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp Cell Res. 1998;244:26-32 pubmed
    ..Evidence presented in this and previous studies suggest that in vivo the ubiquitously expressed PKCI protein does not function as an inhibitor of PKC but rather acts as an enzyme in a yet to be identified pathway. ..
  74. Cen B, Deguchi A, Weinstein I. Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res. 2008;68:5355-62 pubmed publisher
    ..led to increased expression of the tumor suppressor proteins p21(CIP1), p27(KIP1), and Histidine triad protein 1 (HINT1), and their corresponding mRNAs...
  75. Metrick C, Heldwein E. Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21. J Virol. 2016;90:5759-69 pubmed publisher
    ..Additionally, we describe an unanticipated ability of UL21 to bind RNA, which may hint at a yet unexplored function...
  76. Deuschle K, Kepp G, Jeske H. Differential methylation of the circular DNA in geminiviral minichromosomes. Virology. 2016;499:243-258 pubmed publisher
    ..They accumulated in regions of nucleosome-free gaps, but scattered also along the genomic components. These results may hint at a function in specific gene regulation, as well as in virus resistance.
  77. Modic K, Ramshaw B, Betts J, Breznay N, Analytis J, McDonald R, et al. Robust spin correlations at high magnetic fields in the harmonic honeycomb iridates. Nat Commun. 2017;8:180 pubmed publisher
    ..Focus has naturally been drawn to the unusual magnetic orders that hint at the underlying spin correlations...
  78. Meech K, Weryk R, Micheli M, Kleyna J, Hainaut O, Jedicke R, et al. A brief visit from a red and extremely elongated interstellar asteroid. Nature. 2017;: pubmed publisher
    ..Our observations reveal the object to be asteroidal, with no hint of cometary activity despite an approach within 0.25 au of the Sun...
  79. Okada K, Moon H, Finney J, Couture F, Day R, Mure M. WITHDRAWN: PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity. J Biol Chem. 2017;: pubmed publisher
    ..This article has been withdrawn by the authors. Figs 1C, 2A, and 2E contained some inadvertently mislabeled data. The authors state that the mislabeling does not affect the conclusions of the article. ..
  80. Bardaweel S, Ghosh B, Wagner C. Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins. Bioorg Med Chem Lett. 2012;22:558-60 pubmed publisher
    ..hydrolases, Escherichia coli Histidine Triad Nucleotide Binding Protein (ecHinT) and human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Using our established phosphoramidase assay, K(i) values were determined...
  81. Genovese G, Ghosh P, Li H, Rettino A, Sioletic S, Cittadini A, et al. The tumor suppressor HINT1 regulates MITF and ?-catenin transcriptional activity in melanoma cells. Cell Cycle. 2012;11:2206-15 pubmed publisher
    Histidine triad nucleotide-binding protein 1 (HINT1) is a haploinsufficient tumor suppressor gene that inhibits the Wnt/?-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human ..
  82. Fang J, Wang X, He B. Association between common genetic variants in the opioid pathway and smoking behaviors in Chinese men. Behav Brain Funct. 2014;10:2 pubmed publisher
    ..in the genes encoding mu-opioid receptor (MOR) and the MOR-interacting proteins (including OPRM1, ARRB2, and HINT1) with smoking behaviors in Chinese men. A total of 284 subjects (including current and ex-smokers) were recruited...
  83. Kenific C, Wittmann T, Debnath J. Autophagy in adhesion and migration. J Cell Sci. 2016;129:3685-3693 pubmed
    ..to selective degradation of proteins that mediate cellular tension and to integrin trafficking; these findings hint at further roles for autophagy in supporting adhesion and migration...
  84. Wittekindt C, Wuerdemann N, Gattenlohner S, Brobeil A, Wierzbicka M, Wagner S, et al. The role of high-risk human papillomavirus infections in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2017;274:3837-3842 pubmed publisher
    ..Serologic testing of E6/E7 antibodies additionally revealed odds ratios between 2 and 5 as a hint for a weak contribution of high-risk HPV infection and the development of LSCC...
  85. Verhey T, Castellanos M, Chaconas G. Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline. Mol Microbiol. 2017;: pubmed publisher
    ..of amino acid changes on the 3D structure and note differences observed in SCID versus wild type mice that hint at possible amino acid function...
  86. Gubin A, Njoroge J, Bouffard G, Miller J. Gene expression in proliferating human erythroid cells. Genomics. 1999;59:168-77 pubmed
    ..In addition to known transcripts, 44 novel EST were discovered. This transcriptional profile provides the first genomic-scale description of gene activity in erythroid progenitor cells. ..
  87. Cen B, Li H, Weinstein I. Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. 2009;284:5265-76 pubmed publisher
    ..more underlying mechanisms of the tumor suppressing activity of the histidine triad nucleotide-binding protein 1 (HINT1) are not well defined...
  88. Zimon M, Baets J, Almeida Souza L, De Vriendt E, Nikodinovic J, Parman Y, et al. Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia. Nat Genet. 2012;44:1080-3 pubmed publisher
    ..In 33 families, we identified 8 mutations in HINT1 (encoding histidine triad nucleotide-binding protein 1) by combining linkage analyses with next-generation ..
  89. Wang L, Li X, Zhang L, Gao Q. Improved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization. BMC Cancer. 2017;17:513 pubmed publisher
    ..that mTOR inhibitor rapamycin was sensitive to non-small cell lung cancer (NSCLC), and expression of AK1RC3 and HINT1 may be adjunct markers of cell line sensitivity to rapamycin...
  90. Anas M, Sharma R, Dhamodharan V, Pradeepkumar P, Manhas A, Srivastava K, et al. Investigating pharmacological targeting of G-quadruplexes in human malaria parasite. Biochemistry. 2017;: pubmed publisher
    The unique occurrence of G-quadruplexes in AT-rich genome of human malaria parasite P. falciparum hint towards their critical roles in parasite survival, pathogenesis and host immune evasion...
  91. Zhang Y, Li H, Wu H, Shen J, Wang L, Yu M, et al. Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma. Cancer Lett. 2009;275:277-84 pubmed publisher
    The Hint1 protein, a member of the histidine triad (HIT) family, is highly conserved in diverse species and ubiquitously expressed in mammalian tissues...