HIF-1 alpha

Summary

Gene Symbol: HIF-1 alpha
Description: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Alias: HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, ARNT interacting protein, ARNT-interacting protein, HIF-1-alpha, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1
Species: human

Top Publications

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
  2. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
  3. ncbi Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
  4. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
  5. ncbi Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    Cheng Jun Hu
    Abramson Family Cancer Research Institute Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 23:9361-74. 2003
  6. ncbi A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
  7. ncbi RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    Ye V Liu
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 25:207-17. 2007
  8. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
  9. ncbi Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    M Ohh
    Department of Medicine, Brigham and Womens Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 2:423-7. 2000
  10. ncbi Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996

Research Grants

  1. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
  2. Targeting Tumor Angiogenesis with SAHA and Bevacizumab in Kidney Cancer
    Roberto Pili; Fiscal Year: 2007
  3. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
  4. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2009
  5. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2007
  6. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
  7. VEGF Function in B-CLL
    Neil Kay; Fiscal Year: 2007
  8. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
  9. Regulation of VEGF in Tumors by Ras, EGF and PTEN
    Amit Maity; Fiscal Year: 2005
  10. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2010

Detail Information

Publications252 found, 100 shown here

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
    ..This study investigated if angiogenesis or growth factors or their receptors are associated with HIF-1alpha in invasive breast cancer...
  2. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
    ..An absolute requirement for dioxygen as a cosubstrate and iron as cofactor suggests that HIF-PH functions directly as a cellular oxygen sensor...
  3. ncbi Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
    ....
  4. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
    ..Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing...
  5. ncbi Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    Cheng Jun Hu
    Abramson Family Cancer Research Institute Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 23:9361-74. 2003
    ..Importantly, HIF-1alpha (and not HIF-2alpha) stimulates glycolytic gene expression in both types of cells, clearly showing for the first time that HIF-1alpha and HIF-2alpha have unique targets...
  6. ncbi A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    ..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
  7. ncbi RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    Ye V Liu
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 25:207-17. 2007
    ..Thus, RACK1 is an essential component of an O(2)/PHD/VHL-independent mechanism for regulating HIF-1alpha stability through competition with HSP90 and recruitment of the Elongin-C/B ubiquitin ligase complex...
  8. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
  9. ncbi Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    M Ohh
    Department of Medicine, Brigham and Womens Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 2:423-7. 2000
    ..These results strengthen the link between overaccumulation of HIF and development of VHL disease...
  10. ncbi Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
    ..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
  11. ncbi Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression
    Satish L Deshmane
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 284:11364-73. 2009
    ....
  12. ncbi Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008
    ..In conclusion, the data reveal posttranslational modification of the activated form of the Notch receptor and an intricate mode of cross-coupling between the Notch and hypoxia signaling pathways...
  13. ncbi Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    W G An
    Department of Cell and Cancer Biology, Medicine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    Nature 392:405-8. 1998
    ..Our results suggest that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its association with HIF-1alpha...
  14. ncbi Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
    David Zagzag
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York, NY 10016, USA
    Lab Invest 86:1221-32. 2006
    ..We believe this knowledge may lead to a potentially important two-pronged therapy against GBM progression using chemotherapy targeting CXCR4...
  15. ncbi General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 90:4304-8. 1993
    ..These results provide evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to hypoxia...
  16. ncbi Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
    Xiaobo Xia
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4260-5. 2009
    ..These results suggest that the coordinated increase in expression of several oxygen-dependent enzymes by HIF may help compensate for decreased levels of oxygen under conditions of cellular hypoxia...
  17. ncbi Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    Christina Warnecke
    Department of Nephrology and Medical Intensive Care, Virchow Clinic, Charite University Medicine, Berlin, Germany
    FASEB J 18:1462-4. 2004
    ..In conclusion, we found a remarkably restricted target gene specificity of the HIFalpha subunits, which can be overcome in cells with perturbations in the pVHL/HIF system and under forced expression...
  18. ncbi A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia
    Qiliang Cai
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Virol 81:10413-23. 2007
    ..Therefore, these data show that LANA can function not only as an inhibitor of HIF-1alpha suppressor proteins but can also induce nuclear accumulation of HIF-1alpha during KSHV latent infection...
  19. ncbi HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6
    Harjinder Lall
    Medway School of Pharmacy, University of Kent, United Kingdom
    Mol Immunol 45:3045-9. 2008
    ..On the other hand HIF-1alpha protein is selectively required for down-regulation of ASK1 activated during LPS-induced TLR4 downstream signalling...
  20. ncbi Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
    Mircea Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13459-64. 2002
    ..A model compound of this series stabilized HIF in a variety of cells, leading to the increased production of its downstream target, vascular endothelial growth factor...
  21. ncbi Hypoxia inducible factor-1α in human emphysema lung tissue
    M Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 37:775-83. 2011
    ..In conclusion, reduced expression of HIF-1α protein in severe COPD is consistent with the concept of a lung structure maintenance programme which is impaired on a molecular level...
  22. ncbi FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    P C Mahon
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genes Dev 15:2675-86. 2001
    ..Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration...
  23. ncbi Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:2330-4. 2003
    ..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
  24. ncbi Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia
    Li Yin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:257-66. 2007
    ..Importantly, MUC1 also blocks hypoxia-induced apoptosis and necrosis by suppressing accumulation of ROS. These findings indicate that MUC1 attenuates HIF-1alpha activation in a survival response to hypoxic stress...
  25. ncbi Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    Linda Holmquist-Mengelbier
    Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE 205 02 Malmo, Sweden
    Cancer Cell 10:413-23. 2006
    ..Our results demonstrate the relevance of HIF-2alpha in neuroblastoma progression and have general tumor biological implications...
  26. ncbi Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
    Hiroyuki Kato
    Department of Molecular Cell Physiology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 279:41966-74. 2004
    ..Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha..
  27. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  28. ncbi COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70
    Bart van De Sluis
    Complex Genetics Section, DBG Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7332. 2009
    ..Although HIF activity is mainly controlled by ubiquitination and protein degradation by the von Hippel Lindau (pVHL) tumor suppressor gene other mechanisms have recently been identified that regulate HIF signaling independently of pVHL...
  29. ncbi Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    Christine C Hudson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:7004-14. 2002
    ..These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and suggest that the antitumor activity of rapamycin is mediated, in part, through the inhibition of cellular responses to hypoxic stress...
  30. ncbi Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    Patrick van Uden
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 412:477-84. 2008
    ..In conclusion, we find that NF-kappaB can regulate basal TNFalpha and, in certain circumstances, the hypoxia-induced HIF-1alpha...
  31. ncbi miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells
    Sandra Cascio
    Section of Medical Oncology, Department of Surgical and Oncological Sciences, Palermo University, Palermo, Italy
    J Cell Physiol 224:242-9. 2010
    ..In summary, this report demonstrates, for the first time, that the VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner...
  32. ncbi Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  33. ncbi Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha
    Patrick J Pollard
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem J 416:387-94. 2008
    ..Given the importance of histone methylation status in defining patterns of gene expression under different physiological and pathophysiological conditions, these findings predict a role for the HIF system in epigenetic regulation...
  34. ncbi PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis
    Amandine Ginouves
    Institute of Signaling, Developmental Biology, and Cancer Research, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, University of Nice, Centre Antoine Lacassagne, 06189 Nice, France
    Proc Natl Acad Sci U S A 105:4745-50. 2008
    ..However, here we show that chronic hypoxia induces HIF1/2alpha"desensitization" in cellulo and in mice...
  35. ncbi Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase
    Stefan Kaluz
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cancer Res 62:4469-77. 2002
    ..These interdependent pathways function at a lowered O(2) concentration that is, however, above that necessary for HIF-1 alpha stabilization...
  36. ncbi Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
    Donna M Fath
    Cardeza Foundation for Hematologic Research and Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:13612-9. 2006
    ....
  37. ncbi Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    David R Mole
    Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    J Biol Chem 284:16767-75. 2009
    ..Given emerging evidence for biologically distinct functions of HIF-1alpha versus HIF-2alpha understanding the mechanisms restricting HIF-2alpha activity will be of interest...
  38. ncbi Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, D 80636 Munich, Germany
    Mol Biol Cell 18:4691-7. 2007
    ..Together, these findings provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the PI3K/AKT pathway and activation of NFkappaB...
  39. ncbi Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 8556 Kumamoto, Japan
    Breast Cancer Res Treat 110:465-75. 2008
    ..The aim of this study is to clarify characteristics of invasive breast cancer with expression of Hypoxia-induced factor 1alpha (HIF-1alpha) which is induced by hypoxia and signal transduction of growth factors...
  40. ncbi Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    Delin Chen
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:13595-8. 2003
    ..These results have significant implications regarding the molecular mechanism by which p53 is activated by HIF-1 alpha in response to hypoxia...
  41. ncbi Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
    P Carrero
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Biol 20:402-15. 2000
    ....
  42. ncbi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
    ..Thus, HIF-1alpha might support both cell survival and the production of pro-inflammatory cytokines upon TLR7/8 activation...
  43. ncbi Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta
    WonChung Lim
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Republic of Korea
    FEBS Lett 583:1314-8. 2009
    ..We then examined the effect of ER beta on HIF1-alpha transactivation...
  44. ncbi Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    Nobuko Koshikawa
    Laboratory of Cancer Metastasis, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    J Biol Chem 284:33185-94. 2009
    ..These results suggest that the ROS-generating ND6 mutation increases HIF-1alpha transcription via the PI3K-Akt/PKC/HDAC pathway, leading to HIF-1alpha protein accumulation in hypoxic tumor cells...
  45. ncbi Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells
    Malin Pedersen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Biochem Biophys Res Commun 377:98-103. 2008
    ..We also show that SCF-induced accumulation of HIF-1alpha is dependent on both the PI-3-kinase and Ras/MEK/Erk pathways. Our data suggest a novel mechanism of SCF/c-Kit signaling in angiogenesis and tumor progression...
  46. ncbi Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
    Cameron P Bracken
    School of Molecular and Biomedical Science, University of Adelaide, South Australia
    J Biol Chem 281:22575-85. 2006
    ..Interestingly, the initial stabilization of HIF-alpha prior to transactivation up-regulation predicted from in vitro derived hydroxylation data is only true for a subset of cells...
  47. ncbi Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    M E Cockman
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    J Biol Chem 275:25733-41. 2000
    ....
  48. ncbi The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy
    Katie DeClerck
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794, USA
    Front Biosci 15:213-25. 2010
    ..The ability to target the hypoxic compartment should allow longer progression-free survival and overall survival of patients bearing solid tumor malignancies...
  49. ncbi Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
    Mitsuhiro Nakamura
    Department of Microbiology Immunology, Northwestern University, Feinberg School of Medicine, Morton, Chicago, IL 60611, USA
    Virology 387:442-8. 2009
    ..These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers...
  50. ncbi PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia
    G Xenaki
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Oncogene 27:5785-96. 2008
    ..In conclusion, PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha...
  51. ncbi Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    Zhi Bo Han
    The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
    Carcinogenesis 29:1853-61. 2008
    ..Hypoxia and epidermal growth factor receptor signal coexisted in the tumor microenvironment and might promote angiogenesis through HIF-1 alpha-mediated upregulation of SCF and other angiogenic factors...
  52. ncbi Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
    Yong Yuan
    Genome Research Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0505, USA
    J Biol Chem 278:15911-6. 2003
    ..These findings show that cobalt mimics hypoxia, at least in part, by occupying the VHL-binding domain of HIF-alpha and thereby preventing the degradation of HIF-alpha...
  53. ncbi HIF-1 alpha protein as a target for S-nitrosation
    Vadim V Sumbayev
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 535:106-12. 2003
    ..In conclusion, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO...
  54. ncbi HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    Edurne Berra
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    EMBO J 22:4082-90. 2003
    ..Interestingly, PHD2 is upregulated by hypoxia, providing an HIF-1-dependent auto-regulatory mechanism driven by the oxygen tension...
  55. ncbi Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
    Alexandra Grosfeld
    INSERM U 465, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:42953-7. 2002
    ..These data demonstrate that leptin is a new hypoxia-inducible gene, which is stimulated in a placental cell line through HIF-1 interaction with a consensus HRE site located at -116 in the proximal promoter...
  56. ncbi Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
    Jonathan M Elkins
    Oxford Centre for Molecular Sciences and the Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, United Kingdom
    J Biol Chem 278:1802-6. 2003
    ..Conserved structural motifs within FIH imply it is one of an extended family of Fe((II)) oxygenases involved in gene regulation...
  57. ncbi Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
    Guilian Niu
    Beckman Research Institute, Duarte, CA 91010 3000, USA
    Mol Cancer Res 6:1099-105. 2008
    ....
  58. ncbi Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 277:38205-11. 2002
    ..Involvement of the MAP kinase pathway represents a novel mechanism for the induction of HIF-1 alpha protein expression in human cancer cells...
  59. ncbi Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    P J Pollard
    Molecular and Population Genetics Laboratory, London WC2A 3PX, UK
    Hum Mol Genet 14:2231-9. 2005
    ..The basic mechanism of tumorigenesis in HPGL and HLRCC is likely to be pseudo-hypoxic drive, just as it is in von Hippel-Lindau syndrome...
  60. ncbi High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 111:475-80. 2008
    ..69%, P = 0.0002). Glut-1 and CAIX, downstream HIF1 targets, were expressed in 27/30 (90%) and 15/21 (71%) of hereditary cases versus 54/183 (29%) and 24/183 (13%) in ..
  61. ncbi Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
    Rebecca Bilton
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, Nice 06189, France
    J Biol Chem 280:31132-40. 2005
    ..Taken together, our findings demonstrate that ARD1 has limited, if any, impact on the HIF signaling pathway...
  62. ncbi Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP
    K Yamashita
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, Florida 33149, USA
    J Biol Chem 276:12645-53. 2001
    ..The results support essential roles for AP-1, GATA-2, and NF-1 in stabilizing the binding of HIF-1 and promoting recruitment of p300/CBP to the ET-1 hypoxia response complex...
  63. ncbi p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    D E Richard
    Institute of Signaling, Developmental Biology and Cancer Research, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    J Biol Chem 274:32631-7. 1999
    ..This interaction between HIF-1alpha and p42/p44 MAPK suggests a cooperation between hypoxic and growth factor signals that ultimately leads to the increase in HIF-1-mediated gene expression...
  64. ncbi Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2
    Utta Berchner-Pfannschmidt
    Institut fur Physiologie, Universitat Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    J Biol Chem 282:1788-96. 2007
    ..In conclusion, we identified the induction of PHD2 as an underlying mechanism of NO-induced degradation of HIF-1alpha...
  65. ncbi Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914
    J Biol Chem 269:23757-63. 1994
    ..These results support the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis...
  66. ncbi PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    J Biol Chem 279:13506-13. 2004
    ..We conclude that PI3K/Akt contributes to HIF-1alpha stabilization by provoking expression of heat shock proteins...
  67. ncbi MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
    Nianli Sang
    Cardeza Foundation for Hematological Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:14013-9. 2003
    ..Taken together, our data suggest that MAPK signaling facilitates HIF activation through p300/CBP...
  68. ncbi Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors
    Olga Aprelikova
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Cell Biochem 92:491-501. 2004
    ..These data further advance our understanding of the differential role of HIF factors and putative feedback loop in HIF regulation...
  69. ncbi The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
    Jane L Boddy
    Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK
    Clin Cancer Res 11:7658-63. 2005
    ..The study aimed to assess whether a relationship exists in human prostate cancer between expression of the androgen receptor, HIFs, and the key angiogenesis factor, vascular endothelial growth factor (VEGF)...
  70. ncbi c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner
    Bing Yu
    Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Cancer Res 69:7704-12. 2009
    ....
  71. ncbi Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer
    Stephen L Archer
    University of Chicago, Section of Cardiology, IL 60637, USA
    Am J Physiol Heart Circ Physiol 294:H570-8. 2008
    ..Mitochondrial abnormalities that disturb the ROS-HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of PAH and cancer and constitute promising therapeutic targets...
  72. ncbi RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...
  73. ncbi Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese
    Norihiro Yamada
    Department of Ophthalmology, Gunma University Graduate School of Medicine, Japan
    J Clin Endocrinol Metab 90:5841-7. 2005
    ..Vascular endothelial growth factor mRNA levels increase as a result of increased transcriptional activation, mediated predominantly by hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to hypoxia...
  74. ncbi ERK and calcium in activation of HIF-1
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:448-53. 2002
    ..Altogether, these results suggest that calcium and calmodulin would act upstream of ERK in the hypoxia signal transduction pathway leading to enhanced HIF-1 transcriptional activity...
  75. ncbi Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability
    Marten A Schults
    Department of Health Risk Analysis and Toxicology, NUTRIM Research Institute, The Netherlands
    J Biol Chem 285:14558-64. 2010
    ..These data indicate that concurrent exposure of tumor cells to hypoxia and exogenous genotoxins can enhance genetic instability...
  76. ncbi Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration
    Chao Wan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:686-91. 2008
    ..These results identify the HIF-1alpha pathway as a critical mediator of neoangiogenesis required for skeletal regeneration and suggest the application of HIF activators as therapies to improve bone healing...
  77. ncbi Signal transduction to hypoxia-inducible factor 1
    Gregg Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 64:993-8. 2002
    ....
  78. ncbi Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1
    Qing Liu
    Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany
    Blood 104:3993-4001. 2004
    ..Thus, calcium appeared to have a critical role in the regulation of the HIF system and subsequent activation of the PAI-1 gene expression...
  79. ncbi Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo
    Lavinia Nardinocchi
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute Regina Elena, Rome, Italy
    PLoS ONE 5:e15048. 2010
    ..We previously reported that zinc downregulated HIF-1α levels. Here, we evaluated the molecular mechanisms of zinc-induced HIF-1α downregulation and whether zinc affected HIF-1α also in vivo...
  80. ncbi Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia
    Guo min Shen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    FEBS Lett 584:4366-72. 2010
    Hundreds of genes can be regulated by hypoxia-inducible factor 1 (HIF1) under hypoxia. Here we demonstrated a HIF1-mediated induction of protein phosphatase 1, regulatory subunit 3C gene (PPP1R3C) in human MCF7 cells under hypoxia...
  81. ncbi Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m
    Martha C Tissot van Patot
    Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 46:1551-7. 2009
    ..001), as were urinary 15-F(2t)-isoprostanes (p=0.037). HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress...
  82. ncbi BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    Jee Youn Kim
    Department of Pathology, College of Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemoon Koo, Seoul 130 701, Korea
    J Exp Med 199:113-24. 2004
    ..Further, we show that reactive oxygen species and resultant cytochrome c release participate in Noxa-mediated hypoxic cell death. Altogether, our results show that Noxa is induced by HIF-1alpha and mediates hypoxic cell death...
  83. ncbi Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    N Masson
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    EMBO J 20:5197-206. 2001
    ..The definition of two independent destruction domains implicates a more complex system of pVHL-HIF-alpha interactions, but reinforces the role of prolyl hydroxylation as an oxygen-dependent destruction signal...
  84. ncbi Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX
    Chi long Chen
    Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Virchows Arch 457:53-61. 2010
    ..GLUT1 expression (glycolytic phenotype) and CAIX expression (acid-resistant phenotype) may result in a powerful adaptive advantage and represent an aggressive phenotype...
  85. ncbi The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent, UK
    Immunol Cell Biol 88:180-6. 2010
    ..In both cases, downregulation of HIF-1 alpha prolyl hydroxylation correlates with a decrease in intracellular iron (II)...
  86. ncbi Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells
    Preamrudee Poomthavorn
    Murdoch Childrens Research Institute, Centre for Hormone Research, Royal Children s Hospital, University of Melbourne, Flemington Road, 3052 Parkville, Victoria, Australia
    Endocr Relat Cancer 16:991-1004. 2009
    ..These processes are probably responsible for the NB cell transition from an adherent phenotype to a highly migratory, invasive and aggressive NB cell type...
  87. ncbi Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
    Heidi M Sowter
    Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cancer Res 63:6130-4. 2003
    ..Remarkably, among a panel of hypoxia-inducible genes, responses were critically dependent on Hif-1 alpha but not Hif-2 alpha in both endothelial and breast cancer cells but critically dependent on Hif-2 alpha in renal carcinoma cells...
  88. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
    ....
  89. ncbi Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression
    Keyi Zhu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 69:1836-43. 2009
    ..Our data established that PIs down-regulated HIF-1alpha expression in cells that display activation of the unfolded protein response by stimulating phosphorylation of eIF2alpha and inhibiting HIF-1alpha translation...
  90. ncbi Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    R Ravi
    Johns Hopkins Oncology Center, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 USA
    Genes Dev 14:34-44. 2000
    ..These results indicate that amplification of normal HIF-1-dependent responses to hypoxia via loss of p53 function contributes to the angiogenic switch during tumorigenesis...
  91. ncbi Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    Raju R Raval
    The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    Mol Cell Biol 25:5675-86. 2005
    ..These findings indicate that therapeutic approaches to targeting of the HIF system, at least in this setting, will need to take account of HIF isoform-specific functions...
  92. ncbi Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway
    Hyeon Ok Jin
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Gu, Seoul 139 706, Republic of Korea
    Cell Signal 19:1393-403. 2007
    ..These results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway...
  93. ncbi Hypoxia inducible factor 1 alpha regulates matrigel-induced endovascular differentiation under normoxia in a human extravillous trophoblast cell line
    K Fukushima
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Placenta 29:324-31. 2008
    ..differentiation in EVT further, we investigated the role of hypoxia inducible factor (HIF)1A, a subunit of HIF1 transcription factor that regulates not only adaptive responses to hypoxia, but also many cellular functions under ..
  94. ncbi Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line
    Xin Hua Liu
    Department of Medicine, Annenberg Building Room 23 78, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 277:50081-6. 2002
    ....
  95. ncbi Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    David Lando
    Department of Molecular Biosciences Biochemistry, Adelaide University, SA 5005, Australia
    Science 295:858-61. 2002
    ..Full induction of HIF-1alpha and -2alpha, therefore, relies on the abrogation of both Pro and Asn hydroxylation, which during normoxia occur at the degradation and COOH-terminal transactivation domains, respectively...
  96. ncbi Purification and characterization of hypoxia-inducible factor 1
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914
    J Biol Chem 270:1230-7. 1995
    ..We conclude that in both cobalt chloride-treated HeLa cells and hypoxic Hep3B cells HIF-1 is composed of two different subunits: 120-kDa HIF-1 alpha and 91-94-kDa HIF-1 beta...
  97. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
    ..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
  98. ncbi Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway
    Mi Jung Lee
    Department of Pathology and Medical Research Center for Reactive Oxygen Species, College of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Mol Cell Biol 24:3918-27. 2004
    ..Taken together, our data indicate that HGTD-P is a new HIF-1 alpha-responsive proapoptotic molecule that activates mitochondrial apoptotic cascades...
  99. ncbi Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    Toshio Kuwai
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Cancer 105:176-81. 2003
    ..These findings suggest that HIF-1alpha may play a role in angiogenesis and tumor progression via regulation of VEGF in human colorectal carcinoma...
  100. ncbi The experimental study of hypoxia-inducible factor-1alpha and its target genes in spinal cord injury
    H Xiaowei
    Laboratory for Conservation and Utilization of Bio Resources, Yunnan University, Kunming, PR China
    Spinal Cord 44:35-43. 2006
    ....
  101. ncbi Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia
    I Caniggia
    Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Placenta 21:S25-30. 2000
    ..synthesis and degradation of extracellular matrix proteins and their receptors, and changes in the spatial distribution of extracellular matrix proteins, as well as changes in the expression of adhesion molecules (Damsky, Fitzgerald and..

Research Grants70

  1. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  2. Targeting Tumor Angiogenesis with SAHA and Bevacizumab in Kidney Cancer
    Roberto Pili; Fiscal Year: 2007
    ....
  3. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ....
  4. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2009
    ....
  5. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2007
    ....
  6. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ....
  7. VEGF Function in B-CLL
    Neil Kay; Fiscal Year: 2007
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  8. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  9. Regulation of VEGF in Tumors by Ras, EGF and PTEN
    Amit Maity; Fiscal Year: 2005
    ..These experiments will lead to a better understanding of HIF-1 alpha regulation, mechanisms of VEGF overexpression in cancers, and the effects of EGFR activation and Ras and PTEN mutations on gene expression. ..
  10. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2010
    ..b>HIF1( and HIF2( are the two major transcription factors responding to low oxygen (hypoxia) in solid tumors...
  11. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2010
    ..b>HIF1( and HIF2( are the two major transcription factors responding to low oxygen (hypoxia) in solid tumors...
  12. Control by Oxygen of Lens Metabolism and Cataract Formation
    David Beebe; Fiscal Year: 2009
    ..This study will test our prediction that oxygen from the retina is responsible for the "normal," age- related opacification of the lens nucleus. ..
  13. Microelectrode oxygenation control of tumor necrosis
    Neil Forbes; Fiscal Year: 2006
    ..cell death, and determine the extent that poor oxygenation causes tumor necrosis; and 3) demonstrate that a HIF1-alpha response is critical for cell survival in hypoxic tumor tissue...
  14. Oxygen Therapy in Neonatal Hypoxia-Ischemia
    John Zhang; Fiscal Year: 2007
    ..Our specific hypothesis is that the level and expression of inflammatory cytokines and iNOS increased in injured brain tissues and lead to cell death. ..
  15. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ....
  16. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
    ..Aim 3 will examine a possible model for PE in which up-regulation of stable HIF1 alpha (HIF1A) protein is hypothesized to counteract the effects of high O2 during in vitro development of BMP-hESC and ..
  17. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2010
    ..We refer to this as the HRHV axis. Unregulated tumor angiogenesis is known to be tied to hypoxia, HIF1 and VEGF by our work and that of many others, however, it is unclear how the angiogenic stimulus is maintained over ..
  18. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2009
    ..We refer to this as the HRHV axis. Unregulated tumor angiogenesis is known to be tied to hypoxia, HIF1 and VEGF by our work and that of many others, however, it is unclear how the angiogenic stimulus is maintained over ..
  19. The histone deacetylase SIRT6 functions as a co-repressor of Hif1 alpha in glucos
    Raul Mostoslavsky; Fiscal Year: 2010
    ....
  20. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith C Bible; Fiscal Year: 2010
    ..the contributions of effects on TrxR and other reductases, histone modifying enzymes (including HDACs and HMTs), HIF1 and other targets to the cytotoxic selectivity of chaetocin;as well as further investigate mechanisms of cellular ..
  21. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith Bible; Fiscal Year: 2009
    ..the contributions of effects on TrxR and other reductases, histone modifying enzymes (including HDACs and HMTs), HIF1 and other targets to the cytotoxic selectivity of chaetocin; as well as further investigate mechanisms of cellular ..
  22. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN DURDEN; Fiscal Year: 2010
    ..This proposal will provide useful information for the application of SF1126 to the treatment of malignant glial tumors in man and therefore may potentially improve survival of patients with this form of cancer. ..
  23. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN; Fiscal Year: 2009
    ..This proposal will provide useful information for the application of SF1126 to the treatment of malignant glial tumors in man and therefore may potentially improve survival of patients with this form of cancer. ..
  24. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2010
    ..HIF1a, together with constitutively expressed HIF1b, form the heterodimeric transcriptional factor HIF1 that activates a hierarchy of target genes that permit cells to survive under reduced oxygen concentrations...
  25. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  26. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..While the likely severity of such bias has been debated in the epidemiologic literature, there have been no studies to assess the extent of this problem in Hispanics, one of the populations that is most likely to be affected. ..
  27. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura P James; Fiscal Year: 2010
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver'..
  28. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2007
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver's ..
  29. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2007
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  30. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2007
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  31. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2009
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  32. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2009
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver'..
  33. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2007
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  34. Genetic Events in the Development of Renal Cell Carcinoma
    WENDY K RATHMELL; Fiscal Year: 2010
    ..been implicated in many activities, most notably the oxygen dependent regulation of the hypoxia inducible factors HIF1-alpha and HIF2-alpha which trancriptionally regulation a large cohort of hypoxia response genes...
  35. Genetic Events in the Development of Renal Cell Carcinoma
    WENDY RATHMELL; Fiscal Year: 2007
    ..been implicated in many activities, most notably the oxygen dependent regulation of the hypoxia inducible factors HIF1-alpha and HIF2-alpha which trancriptionally regulation a large cohort of hypoxia response genes...