HIF-1 alpha

Summary

Gene Symbol: HIF-1 alpha
Description: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Alias: HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, ARNT interacting protein, ARNT-interacting protein, HIF-1-alpha, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1
Species: human

Top Publications

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
  2. doi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
  3. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
  4. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
  5. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
  6. ncbi The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    P H Maxwell
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nature 399:271-5. 1999
  7. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
  8. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
  9. pmc Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    Christine C Hudson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:7004-14. 2002
  10. pmc Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    Patrick van Uden
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 412:477-84. 2008

Detail Information

Publications287 found, 100 shown here

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
    ..This study investigated if angiogenesis or growth factors or their receptors are associated with HIF-1alpha in invasive breast cancer...
  2. doi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
    ..However, molecular details of how bacteria activate HIF-1 remain unclear. Here, we pursued the role of bacterial siderophores in HIF-1 activation during infection with Enterobacteriaceae...
  3. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
    ....
  4. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
    ..An absolute requirement for dioxygen as a cosubstrate and iron as cofactor suggests that HIF-PH functions directly as a cellular oxygen sensor...
  5. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
    ..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
  6. ncbi The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    P H Maxwell
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nature 399:271-5. 1999
    ..Thus, constitutive HIF-1 activation may underlie the angiogenic phenotype of VHL-associated tumours. The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing...
  7. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    ..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
  8. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
    ..Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing...
  9. pmc Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    Christine C Hudson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:7004-14. 2002
    ..These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and suggest that the antitumor activity of rapamycin is mediated, in part, through the inhibition of cellular responses to hypoxic stress...
  10. pmc Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    Patrick van Uden
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 412:477-84. 2008
    ..In conclusion, we find that NF-kappaB can regulate basal TNFalpha and, in certain circumstances, the hypoxia-induced HIF-1alpha...
  11. pmc RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    Ye V Liu
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 25:207-17. 2007
    ..Thus, RACK1 is an essential component of an O(2)/PHD/VHL-independent mechanism for regulating HIF-1alpha stability through competition with HSP90 and recruitment of the Elongin-C/B ubiquitin ligase complex...
  12. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  13. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
  14. ncbi Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    Tilman Sanchez-Elsner
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Biol Chem 277:43799-808. 2002
    ..We propose that basal endoglin transcription (highly dependent on Sp1) may switch from a constitutive to an inducible state through Sp1 interaction with HIF-1 and Smad transcription factors, induced by hypoxia and TGF-beta, respectively...
  15. ncbi Signal transduction to hypoxia-inducible factor 1
    Gregg Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 64:993-8. 2002
    ....
  16. ncbi p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    D E Richard
    Institute of Signaling, Developmental Biology and Cancer Research, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    J Biol Chem 274:32631-7. 1999
    ..This interaction between HIF-1alpha and p42/p44 MAPK suggests a cooperation between hypoxic and growth factor signals that ultimately leads to the increase in HIF-1-mediated gene expression...
  17. pmc Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression
    Satish L Deshmane
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 284:11364-73. 2009
    ....
  18. pmc Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    Xiaofeng Zheng
    Departments of Cell and Molecular Biology and Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3368-73. 2008
    ..In conclusion, the data reveal posttranslational modification of the activated form of the Notch receptor and an intricate mode of cross-coupling between the Notch and hypoxia signaling pathways...
  19. ncbi Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
    Yong Yuan
    Genome Research Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0505, USA
    J Biol Chem 278:15911-6. 2003
    ..These findings show that cobalt mimics hypoxia, at least in part, by occupying the VHL-binding domain of HIF-alpha and thereby preventing the degradation of HIF-alpha...
  20. ncbi Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    W G An
    Department of Cell and Cancer Biology, Medicine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    Nature 392:405-8. 1998
    ..Our results suggest that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its association with HIF-1alpha...
  21. pmc Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    Zhang Lei
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    PLoS ONE 4:e7629. 2009
    ..Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations...
  22. pmc BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression
    M Yan
    Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Br J Cancer 101:1168-74. 2009
    ..There are limited data regarding the hypoxia pathway in familial breast cancers. We therefore performed a study of hypoxic factors in BRCA1, BRCA2 and BRCAX breast cancers...
  23. ncbi IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    Yun Jin Jung
    Cell and Cancer Biology Branch, CCR, National Cancer Institute, 9610 Medical Center Dr, Suite 300, Rockville, Maryland 20850, USA
    FASEB J 17:2115-7. 2003
    ..Thus, HIF-1 is identified as a pivotal transcription factor linking the inflammatory and oncogenic pathways...
  24. pmc Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    Cheng Jun Hu
    Abramson Family Cancer Research Institute Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 23:9361-74. 2003
    ..Importantly, HIF-1alpha (and not HIF-2alpha) stimulates glycolytic gene expression in both types of cells, clearly showing for the first time that HIF-1alpha and HIF-2alpha have unique targets...
  25. ncbi High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 111:475-80. 2008
    ..69%, P = 0.0002). Glut-1 and CAIX, downstream HIF1 targets, were expressed in 27/30 (90%) and 15/21 (71%) of hereditary cases versus 54/183 (29%) and 24/183 (13%) in ..
  26. ncbi Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
    David Zagzag
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York, NY 10016, USA
    Lab Invest 86:1221-32. 2006
    ..We believe this knowledge may lead to a potentially important two-pronged therapy against GBM progression using chemotherapy targeting CXCR4...
  27. pmc Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
    Xiaobo Xia
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4260-5. 2009
    ..These results suggest that the coordinated increase in expression of several oxygen-dependent enzymes by HIF may help compensate for decreased levels of oxygen under conditions of cellular hypoxia...
  28. pmc A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia
    Qiliang Cai
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Virol 81:10413-23. 2007
    ..Therefore, these data show that LANA can function not only as an inhibitor of HIF-1alpha suppressor proteins but can also induce nuclear accumulation of HIF-1alpha during KSHV latent infection...
  29. pmc Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, United Kingdom
    PLoS ONE 7:e34259. 2012
    ..This transcription complex facilitates generation of both pro-angiogenic and inflammatory cytokines in mast cells but has a differential role in basophil stimulation comparing IgE-dependent triggering with innate immune stimuli...
  30. doi Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α
    M Koslowski
    TRON Center for Translational Oncology and Immunology GmbH, Mainz, Germany
    Oncogene 30:876-82. 2011
    ..Our results provide novel and highly unexpected insights into the complexity of HIF-1α regulation in cancer cells and implicate that tumor-associated CpG demethylation augments HIF-1α-mediated effects on malignant cell growth...
  31. pmc Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer
    Jean Philippe Dales
    Plateforme Transcriptome, CRO2, Marseille, France
    BMC Med 8:44. 2010
    ..The prognostic relevance of HIF-1alpha protein overexpression has been shown in breast cancer. The impact of HIF-1alpha alternative splice variant expression on breast cancer prognosis in terms of metastasis risk is not well known...
  32. ncbi Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast
    Hirotaka Nishi
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku, Tokyo 160 0023, Japan
    Endocrinology 145:4113-8. 2004
    ..Our results provide evidence that regulation of TGF-beta3 promoter activity by HIF-1 represents a mechanism for trophoblast differentiation during hypoxia...
  33. ncbi Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 180:4697-705. 2008
    ..Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen...
  34. ncbi Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:2330-4. 2003
    ..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
  35. doi HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6
    Harjinder Lall
    Medway School of Pharmacy, University of Kent, United Kingdom
    Mol Immunol 45:3045-9. 2008
    ..On the other hand HIF-1alpha protein is selectively required for down-regulation of ASK1 activated during LPS-induced TLR4 downstream signalling...
  36. doi Hypoxia inducible factor-1α in human emphysema lung tissue
    M Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 37:775-83. 2011
    ..In conclusion, reduced expression of HIF-1α protein in severe COPD is consistent with the concept of a lung structure maintenance programme which is impaired on a molecular level...
  37. pmc Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
    Mircea Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13459-64. 2002
    ..A model compound of this series stabilized HIF in a variety of cells, leading to the increased production of its downstream target, vascular endothelial growth factor...
  38. pmc FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    P C Mahon
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genes Dev 15:2675-86. 2001
    ..Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration...
  39. ncbi Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia
    Li Yin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:257-66. 2007
    ..Importantly, MUC1 also blocks hypoxia-induced apoptosis and necrosis by suppressing accumulation of ROS. These findings indicate that MUC1 attenuates HIF-1alpha activation in a survival response to hypoxic stress...
  40. doi The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 284:5332-42. 2009
    ....
  41. pmc Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    Raju R Raval
    The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    Mol Cell Biol 25:5675-86. 2005
    ..These findings indicate that therapeutic approaches to targeting of the HIF system, at least in this setting, will need to take account of HIF isoform-specific functions...
  42. doi MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression
    Sebastien Aubert
    Institut National de Santé et de Recherche Médicale, U837, Jean Pierre Aubert Research Center, Lille, France
    Cancer Res 69:5707-15. 2009
    ..Altogether, these results show that MUC1 is directly regulated by HIF-1alpha and affects the invasive and migration properties of renal cancer cells. Thus, MUC1 could serve as a potential therapeutic target in cRCC...
  43. pmc BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    Jee Youn Kim
    Department of Pathology, College of Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemoon Koo, Seoul 130 701, Korea
    J Exp Med 199:113-24. 2004
    ..Further, we show that reactive oxygen species and resultant cytochrome c release participate in Noxa-mediated hypoxic cell death. Altogether, our results show that Noxa is induced by HIF-1alpha and mediates hypoxic cell death...
  44. ncbi Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
    Hiroyuki Kato
    Department of Molecular Cell Physiology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 279:41966-74. 2004
    ..Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha..
  45. ncbi Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    Linda Holmquist-Mengelbier
    Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE 205 02 Malmo, Sweden
    Cancer Cell 10:413-23. 2006
    ..Our results demonstrate the relevance of HIF-2alpha in neuroblastoma progression and have general tumor biological implications...
  46. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  47. doi miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells
    Sandra Cascio
    Section of Medical Oncology, Department of Surgical and Oncological Sciences, Palermo University, Palermo, Italy
    J Cell Physiol 224:242-9. 2010
    ..In summary, this report demonstrates, for the first time, that the VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner...
  48. doi Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha
    Patrick J Pollard
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem J 416:387-94. 2008
    ..Given the importance of histone methylation status in defining patterns of gene expression under different physiological and pathophysiological conditions, these findings predict a role for the HIF system in epigenetic regulation...
  49. pmc PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis
    Amandine Ginouves
    Institute of Signaling, Developmental Biology, and Cancer Research, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, University of Nice, Centre Antoine Lacassagne, 06189 Nice, France
    Proc Natl Acad Sci U S A 105:4745-50. 2008
    ..However, here we show that chronic hypoxia induces HIF1/2alpha"desensitization" in cellulo and in mice...
  50. ncbi Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    Dominador J Manalo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 105:659-69. 2005
    ....
  51. ncbi Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    David Lando
    Department of Molecular Biosciences Biochemistry, Adelaide University, SA 5005, Australia
    Science 295:858-61. 2002
    ..Full induction of HIF-1alpha and -2alpha, therefore, relies on the abrogation of both Pro and Asn hydroxylation, which during normoxia occur at the degradation and COOH-terminal transactivation domains, respectively...
  52. ncbi In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    C M Wiener
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biochem Biophys Res Commun 225:485-8. 1996
    ..The ubiquitous in vivo expression of HIF-1 alpha and HIF-1 beta (ARNT) mRNA is consistent with the proposed role of HIF-1 in coordinating adaptive transcriptional responses to hypoxia...
  53. pmc General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 90:4304-8. 1993
    ..These results provide evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to hypoxia...
  54. ncbi Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    P J Pollard
    Molecular and Population Genetics Laboratory, London WC2A 3PX, UK
    Hum Mol Genet 14:2231-9. 2005
    ..The basic mechanism of tumorigenesis in HPGL and HLRCC is likely to be pseudo-hypoxic drive, just as it is in von Hippel-Lindau syndrome...
  55. ncbi MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
    Nianli Sang
    Cardeza Foundation for Hematological Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:14013-9. 2003
    ..Taken together, our data suggest that MAPK signaling facilitates HIF activation through p300/CBP...
  56. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships...
  57. pmc Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    David R Mole
    Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    J Biol Chem 284:16767-75. 2009
    ..Given emerging evidence for biologically distinct functions of HIF-1alpha versus HIF-2alpha understanding the mechanisms restricting HIF-2alpha activity will be of interest...
  58. pmc Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
    Donna M Fath
    Cardeza Foundation for Hematologic Research and Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:13612-9. 2006
    ....
  59. ncbi Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    Delin Chen
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:13595-8. 2003
    ..These results have significant implications regarding the molecular mechanism by which p53 is activated by HIF-1 alpha in response to hypoxia...
  60. ncbi Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase
    Stefan Kaluz
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cancer Res 62:4469-77. 2002
    ..These interdependent pathways function at a lowered O(2) concentration that is, however, above that necessary for HIF-1 alpha stabilization...
  61. pmc Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
    Rachida S BelAiba
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, D 80636 Munich, Germany
    Mol Biol Cell 18:4691-7. 2007
    ..Together, these findings provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the PI3K/AKT pathway and activation of NFkappaB...
  62. pmc Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
    P Carrero
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Biol 20:402-15. 2000
    ....
  63. doi Mouse snail is a target gene for HIF
    Daochun Luo
    Physiology and Experimental Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
    Mol Cancer Res 9:234-45. 2011
    ..Our findings identify snail as a HIF target gene and provide novel insights into the regulation of snail and hypoxia-induced EMT...
  64. pmc Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions
    Caroline N Mills
    Department of Biochemistry and Microbiology, Joan C, Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
    Mol Cancer 8:104. 2009
    ....
  65. pmc TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype
    Gianluca Storci
    Center for Applied Biomedical Research CRBA, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Cell Physiol 225:682-91. 2010
    ..we show that TNFα treatment of human breast cancer cells up-regulates SLUG with a dependency on canonical NF-κB/HIF1α signaling, which is strongly enhanced by p53 inactivation...
  66. pmc Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    R Ravi
    Johns Hopkins Oncology Center, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 USA
    Genes Dev 14:34-44. 2000
    ..These results indicate that amplification of normal HIF-1-dependent responses to hypoxia via loss of p53 function contributes to the angiogenic switch during tumorigenesis...
  67. ncbi The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation
    N V Iyer
    Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Genomics 52:159-65. 1998
    ..The proximal 300 bp of 5' flanking sequences was 83% identical, including the SP1 sites and transcription initiation sites. These results suggest evolutionary selection for maintenance of HIF1A structure, function, and regulation...
  68. doi SWI/SNF regulates the cellular response to hypoxia
    Niall S Kenneth
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 284:4123-31. 2009
    ..These results reveal a previously uncharacterized dependence of hypoxia signaling on the SWI/SNF complex and demonstrate a new level of control over the hypoxia-inducible factor-1alpha system...
  69. pmc Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 28:7081-95. 2008
    ..Therefore, HAF is the key mediator of a new HIF-1alpha-specific degradation pathway that degrades HIF-1alpha through a new, oxygen-independent mechanism...
  70. doi 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation
    Gemma Olmos
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Alcala, 28471, Alcala de Henares, Madrid, Spain
    Cell Mol Life Sci 66:2167-80. 2009
    ..Therefore, expression of HIF-1alpha is also modulated by lysosomal degradation...
  71. ncbi Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    Christina Warnecke
    Department of Nephrology and Medical Intensive Care, Virchow Clinic, Charite University Medicine, Berlin, Germany
    FASEB J 18:1462-4. 2004
    ..In conclusion, we found a remarkably restricted target gene specificity of the HIFalpha subunits, which can be overcome in cells with perturbations in the pVHL/HIF system and under forced expression...
  72. ncbi Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo
    David L Gillespie
    Department of Neurosurgery, Huntsman Cancer Institute in the Division of Pediatric Hematology Oncology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Clin Cancer Res 13:2441-8. 2007
    ..Hypoxia inducible factor-1alpha (HIF-1alpha) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including gliomas...
  73. pmc Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo
    Lavinia Nardinocchi
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute Regina Elena, Rome, Italy
    PLoS ONE 5:e15048. 2010
    ..We previously reported that zinc downregulated HIF-1α levels. Here, we evaluated the molecular mechanisms of zinc-induced HIF-1α downregulation and whether zinc affected HIF-1α also in vivo...
  74. doi Expressions of hypoxia-inducible factor-1α and hexokinase-II in gastric adenocarcinoma: the impact on prognosis and correlation to clinicopathologic features
    Miao Zhen Qiu
    State Key Laboratory of Oncology in South China, Guangzhou 510060, China
    Tumour Biol 32:159-66. 2011
    ..022). Both HIF-1α and HK-II were overexpressed in gastric adenocarcinoma. The multivariate Cox analysis revealed that both of them were independent factors on survival of gastric adenocarcinoma patients...
  75. ncbi Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
    Alexandra Grosfeld
    INSERM U 465, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 277:42953-7. 2002
    ..These data demonstrate that leptin is a new hypoxia-inducible gene, which is stimulated in a placental cell line through HIF-1 interaction with a consensus HRE site located at -116 in the proximal promoter...
  76. pmc Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene
    Chuan Shen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Cancer Discov 1:222-35. 2011
    ..In this article, we identify focal, homozygous deletions of the HIF1α locus on 14q in clear cell renal carcinoma cell lines...
  77. ncbi Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer
    Yutaka Yamamoto
    Department of Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 8556 Kumamoto, Japan
    Breast Cancer Res Treat 110:465-75. 2008
    ..The aim of this study is to clarify characteristics of invasive breast cancer with expression of Hypoxia-induced factor 1alpha (HIF-1alpha) which is induced by hypoxia and signal transduction of growth factors...
  78. doi Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX
    Chi long Chen
    Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Virchows Arch 457:53-61. 2010
    ..GLUT1 expression (glycolytic phenotype) and CAIX expression (acid-resistant phenotype) may result in a powerful adaptive advantage and represent an aggressive phenotype...
  79. pmc HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 176:2292-301. 2010
    ..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications...
  80. ncbi Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan
    Pin Yi Lin
    Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Oral Pathol Med 37:18-25. 2008
    ..Overexpression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) has been found to be significantly associated with the tumor invasion, lymph node metastasis, clinical stage, and prognosis of a variety of human cancers...
  81. ncbi Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  82. pmc Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4
    Helen J Knowles
    Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, Oxford, OX3 7LD, UK
    FASEB J 24:4648-59. 2010
    ....
  83. pmc COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70
    Bart van De Sluis
    Complex Genetics Section, DBG Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7332. 2009
    ..Although HIF activity is mainly controlled by ubiquitination and protein degradation by the von Hippel Lindau (pVHL) tumor suppressor gene other mechanisms have recently been identified that regulate HIF signaling independently of pVHL...
  84. doi Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta
    WonChung Lim
    College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Kwang Jin Gu, Seoul 143 747, Republic of Korea
    FEBS Lett 583:1314-8. 2009
    ..We then examined the effect of ER beta on HIF1-alpha transactivation...
  85. pmc Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    Nobuko Koshikawa
    Laboratory of Cancer Metastasis, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    J Biol Chem 284:33185-94. 2009
    ..These results suggest that the ROS-generating ND6 mutation increases HIF-1alpha transcription via the PI3K-Akt/PKC/HDAC pathway, leading to HIF-1alpha protein accumulation in hypoxic tumor cells...
  86. doi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
    ..Thus, HIF-1alpha might support both cell survival and the production of pro-inflammatory cytokines upon TLR7/8 activation...
  87. ncbi Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    M E Cockman
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    J Biol Chem 275:25733-41. 2000
    ....
  88. ncbi Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
    Cameron P Bracken
    School of Molecular and Biomedical Science, University of Adelaide, South Australia
    J Biol Chem 281:22575-85. 2006
    ..Interestingly, the initial stabilization of HIF-alpha prior to transactivation up-regulation predicted from in vitro derived hydroxylation data is only true for a subset of cells...
  89. doi Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells
    Malin Pedersen
    Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Biochem Biophys Res Commun 377:98-103. 2008
    ..We also show that SCF-induced accumulation of HIF-1alpha is dependent on both the PI-3-kinase and Ras/MEK/Erk pathways. Our data suggest a novel mechanism of SCF/c-Kit signaling in angiogenesis and tumor progression...
  90. ncbi The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy
    Katie DeClerck
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794, USA
    Front Biosci (Landmark Ed) 15:213-25. 2010
    ..The ability to target the hypoxic compartment should allow longer progression-free survival and overall survival of patients bearing solid tumor malignancies...
  91. pmc Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
    Mitsuhiro Nakamura
    Department of Microbiology Immunology, Northwestern University, Feinberg School of Medicine, Morton, Chicago, IL 60611, USA
    Virology 387:442-8. 2009
    ..These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers...
  92. doi Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    Zhi Bo Han
    The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
    Carcinogenesis 29:1853-61. 2008
    ..Hypoxia and epidermal growth factor receptor signal coexisted in the tumor microenvironment and might promote angiogenesis through HIF-1 alpha-mediated upregulation of SCF and other angiogenic factors...
  93. ncbi HIF-1 alpha protein as a target for S-nitrosation
    Vadim V Sumbayev
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 535:106-12. 2003
    ..In conclusion, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO...
  94. pmc PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia
    G Xenaki
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Oncogene 27:5785-96. 2008
    ..In conclusion, PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha...
  95. ncbi HIF-dependent induction of adenosine A2B receptor in hypoxia
    Tianqing Kong
    Center for Experimental Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 20:2242-50. 2006
    ..These findings may provide an important link between hypoxia and metabolic conditions associated with inflammation and angiogenesis...
  96. ncbi HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    Huafeng Zhang
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 11:407-20. 2007
    ..We demonstrate that transcription of the gene encoding the coactivator PGC-1beta is C-MYC dependent and that loss of PGC-1beta expression is a major factor contributing to reduced respiration in VHL-deficient renal carcinoma cells...
  97. ncbi Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients
    Nigel J P Beasley
    Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Cancer Res 62:2493-7. 2002
    ..Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027)...
  98. ncbi Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    M Ohh
    Department of Medicine, Brigham and Womens Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 2:423-7. 2000
    ..These results strengthen the link between overaccumulation of HIF and development of VHL disease...
  99. ncbi HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
    Sandra Turcotte
    Laboratoire de Medecine Moleculaire, Hopital Sainte Justine, Universite du Quebec a Montreal, CP 8888, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3P8
    J Cell Sci 116:2247-60. 2003
    ..Together, these results support a model where ROS upregulate Rho protein expression and where active RhoA is required for HIF-1alpha accumulation during hypoxia...
  100. doi Antisense hypoxia-inducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma
    Fengjun Liu
    Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China
    Cancer Sci 99:2055-61. 2008
    ..Antisense HIF-1alpha therapy warrants investigation as a therapeutic strategy to enhance the efficacy of doxorubicin for treating HCC...
  101. doi A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}
    Shan Hua Li
    Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea
    Mol Cancer Ther 7:3729-38. 2008
    ..Given these results, we suggest that the functional inactivation of HIF-alpha contributes to the YC-1-induced deregulation of hypoxia-induced genes...

Research Grants70

  1. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  2. Targeting Tumor Angiogenesis with SAHA and Bevacizumab in Kidney Cancer
    Roberto Pili; Fiscal Year: 2007
    ....
  3. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ....
  4. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2009
    ....
  5. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2007
    ....
  6. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ....
  7. VEGF Function in B-CLL
    Neil Kay; Fiscal Year: 2007
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  8. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  9. Regulation of VEGF in Tumors by Ras, EGF and PTEN
    Amit Maity; Fiscal Year: 2005
    ..These experiments will lead to a better understanding of HIF-1 alpha regulation, mechanisms of VEGF overexpression in cancers, and the effects of EGFR activation and Ras and PTEN mutations on gene expression. ..
  10. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2010
    ..b>HIF1( and HIF2( are the two major transcription factors responding to low oxygen (hypoxia) in solid tumors...
  11. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2010
    ..b>HIF1( and HIF2( are the two major transcription factors responding to low oxygen (hypoxia) in solid tumors...
  12. Control by Oxygen of Lens Metabolism and Cataract Formation
    David Beebe; Fiscal Year: 2009
    ..This study will test our prediction that oxygen from the retina is responsible for the "normal," age- related opacification of the lens nucleus. ..
  13. Microelectrode oxygenation control of tumor necrosis
    Neil Forbes; Fiscal Year: 2006
    ..cell death, and determine the extent that poor oxygenation causes tumor necrosis; and 3) demonstrate that a HIF1-alpha response is critical for cell survival in hypoxic tumor tissue...
  14. Oxygen Therapy in Neonatal Hypoxia-Ischemia
    John Zhang; Fiscal Year: 2007
    ..Our specific hypothesis is that the level and expression of inflammatory cytokines and iNOS increased in injured brain tissues and lead to cell death. ..
  15. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ....
  16. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
    ..Aim 3 will examine a possible model for PE in which up-regulation of stable HIF1 alpha (HIF1A) protein is hypothesized to counteract the effects of high O2 during in vitro development of BMP-hESC and ..
  17. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2010
    ..We refer to this as the HRHV axis. Unregulated tumor angiogenesis is known to be tied to hypoxia, HIF1 and VEGF by our work and that of many others, however, it is unclear how the angiogenic stimulus is maintained over ..
  18. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2009
    ..We refer to this as the HRHV axis. Unregulated tumor angiogenesis is known to be tied to hypoxia, HIF1 and VEGF by our work and that of many others, however, it is unclear how the angiogenic stimulus is maintained over ..
  19. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith C Bible; Fiscal Year: 2010
    ..the contributions of effects on TrxR and other reductases, histone modifying enzymes (including HDACs and HMTs), HIF1 and other targets to the cytotoxic selectivity of chaetocin;as well as further investigate mechanisms of cellular ..
  20. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith Bible; Fiscal Year: 2009
    ..the contributions of effects on TrxR and other reductases, histone modifying enzymes (including HDACs and HMTs), HIF1 and other targets to the cytotoxic selectivity of chaetocin; as well as further investigate mechanisms of cellular ..
  21. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN DURDEN; Fiscal Year: 2010
    ..This proposal will provide useful information for the application of SF1126 to the treatment of malignant glial tumors in man and therefore may potentially improve survival of patients with this form of cancer. ..
  22. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN; Fiscal Year: 2009
    ..This proposal will provide useful information for the application of SF1126 to the treatment of malignant glial tumors in man and therefore may potentially improve survival of patients with this form of cancer. ..
  23. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2010
    ..HIF1a, together with constitutively expressed HIF1b, form the heterodimeric transcriptional factor HIF1 that activates a hierarchy of target genes that permit cells to survive under reduced oxygen concentrations...
  24. The histone deacetylase SIRT6 functions as a co-repressor of Hif1 alpha in glucos
    Raul Mostoslavsky; Fiscal Year: 2010
    ....
  25. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  26. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..While the likely severity of such bias has been debated in the epidemiologic literature, there have been no studies to assess the extent of this problem in Hispanics, one of the populations that is most likely to be affected. ..
  27. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura P James; Fiscal Year: 2010
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver'..
  28. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2007
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver's ..
  29. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2007
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  30. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2007
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  31. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2009
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  32. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2009
    ..Oxidative stress, hypoxia inducible factor 1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) appear to play central roles in the liver'..
  33. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2007
    ..They will also provide new information concerning the function of EGLN-catalyzed proline hydroxylation as a novel mechanism for altering protein function in neurons. ..
  34. Genetic Events in the Development of Renal Cell Carcinoma
    WENDY K RATHMELL; Fiscal Year: 2010
    ..been implicated in many activities, most notably the oxygen dependent regulation of the hypoxia inducible factors HIF1-alpha and HIF2-alpha which trancriptionally regulation a large cohort of hypoxia response genes...
  35. Genetic Events in the Development of Renal Cell Carcinoma
    WENDY RATHMELL; Fiscal Year: 2007
    ..been implicated in many activities, most notably the oxygen dependent regulation of the hypoxia inducible factors HIF1-alpha and HIF2-alpha which trancriptionally regulation a large cohort of hypoxia response genes...