HGS

Summary

Gene Symbol: HGS
Description: hepatocyte growth factor-regulated tyrosine kinase substrate
Alias: HRS, human growth factor-regulated tyrosine kinase substrate, protein pp110
Species: human

Top Publications

  1. pmc Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial
    Andreas Umgelter
    Medizinische Klinik und Poliklinik der Technischen Universität München, Ismaningerstrasse 22, 81675 Munchen, Germany
    Crit Care 12:R4. 2008
  2. pmc The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation
    Katy Janvier
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1001265. 2011
  3. ncbi Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4
    Menachem Katz
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Traffic 3:740-51. 2002
  4. ncbi Role of Hrs in maturation of autophagosomes in mammalian cells
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 360:721-7. 2007
  5. ncbi The biogenesis of multivesicular endosomes
    Jean Gruenberg
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nat Rev Mol Cell Biol 5:317-23. 2004
  6. pmc Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12414-9. 2003
  7. pmc Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
    D J Gillooly
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    EMBO J 19:4577-88. 2000
  8. pmc Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction
    Young Jun Im
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0580, USA
    Structure 18:1536-47. 2010
  9. ncbi The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding
    Melissa D Stuchell
    Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132 3201, USA
    J Biol Chem 279:36059-71. 2004
  10. pmc Hrs recruits clathrin to early endosomes
    C Raiborg
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    EMBO J 20:5008-21. 2001

Detail Information

Publications251 found, 100 shown here

  1. pmc Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial
    Andreas Umgelter
    Medizinische Klinik und Poliklinik der Technischen Universität München, Ismaningerstrasse 22, 81675 Munchen, Germany
    Crit Care 12:R4. 2008
    ..in cirrhotic patients may cause a specific kind of functional renal failure termed hepato-renal syndrome (HRS). It contributes to the high incidence of renal failure in cirrhotic intensive care unit (ICU) patients...
  2. pmc The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation
    Katy Janvier
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1001265. 2011
    ..We found that HRS, a key component of the ESCRT-0 complex, promotes efficient release of HIV-1 and that siRNA-mediated HRS depletion ..
  3. ncbi Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4
    Menachem Katz
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Traffic 3:740-51. 2002
    ..By studying Hgs, a mammalian homolog of a yeast vacuolar-sorting adaptor, we provide information on the less understood, ligand-..
  4. ncbi Role of Hrs in maturation of autophagosomes in mammalian cells
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 360:721-7. 2007
    ..The molecular process of autophagy is still unclear. Here we demonstrate that Hrs, a master regulator in endosomal protein sorting, plays critical roles for the autophagic degradation of non-..
  5. ncbi The biogenesis of multivesicular endosomes
    Jean Gruenberg
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nat Rev Mol Cell Biol 5:317-23. 2004
  6. pmc Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12414-9. 2003
    ....
  7. pmc Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
    D J Gillooly
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    EMBO J 19:4577-88. 2000
    ....
  8. pmc Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction
    Young Jun Im
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0580, USA
    Structure 18:1536-47. 2010
    ..4-1.6 Å structures of the human TSG101 UEV domain alone and with wild-type and mutant HIV-1 PTAP and Hrs PSAP nonapeptides...
  9. ncbi The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding
    Melissa D Stuchell
    Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132 3201, USA
    J Biol Chem 279:36059-71. 2004
    ..Taken together, these experiments define new components of the human ESCRT-I complex and characterize several TSG101 protein/protein interactions required for HIV-1 budding and infectivity...
  10. pmc Hrs recruits clathrin to early endosomes
    C Raiborg
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    EMBO J 20:5008-21. 2001
    The hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, has been implicated in intracellular trafficking and signal transduction...
  11. ncbi Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein
    Matthew J Hawryluk
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Traffic 7:262-81. 2006
    ..As epsin interacts with eps15, which also contains a UIM region that binds to polyubiquitin, epsin and eps15 appear to be central components of the vertebrate poly/multiubiquitin-sorting endocytic clathrin machinery...
  12. pmc Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
    Harald Husebye
    Institute of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
    EMBO J 25:683-92. 2006
    ..with the ubiquitin-binding endosomal sorting protein hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs. Inhibition of endocytosis and endosomal sorting increased LPS signaling...
  13. ncbi Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
    Camilla Raiborg
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Nat Cell Biol 4:394-8. 2002
    ..Here we show that the hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, is involved in the endosomal sorting of ubiquitinated membrane proteins...
  14. ncbi Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor
    L S Chin
    Department of Pharmacology and of Cell and Molecular Physiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 276:7069-78. 2001
    Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a mammalian homologue of yeast vacuolar protein sorting (Vps) protein Vps27p; however, the role of Hrs in lysosomal trafficking is unclear...
  15. pmc Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling
    Aylin C Hanyaloglu
    University of California, San Francisco, CA 94143 2140, USA
    EMBO J 24:2265-83. 2005
    Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is well known to terminate cell signaling by sorting activated receptors to the MVB/lysosomal pathway...
  16. ncbi Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
    Satoshi Hirano
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305 0801, Japan
    Nat Struct Mol Biol 13:272-7. 2006
    b>Hrs has an essential role in sorting of monoubiquitinated receptors to multivesicular bodies for lysosomal degradation, through recognition of ubiquitinated receptors by its ubiquitin-interacting motif (UIM)...
  17. pmc The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle production
    Fadila Bouamr
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Virol 81:2909-22. 2007
    ..In uninfected cells, the Hrs protein recruits the ESCRT-I complex to the endosome, also through an interaction with Tsg101, to promote the ..
  18. pmc HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein
    Owen Pornillos
    Department of Biochemistry, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA
    J Cell Biol 162:425-34. 2003
    ..the COOH-terminal region of the endosomal protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs; residues 222-777)...
  19. pmc Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation
    M Razi
    Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Mol Biol Cell 17:3469-83. 2006
    ..In contrast, depletion of hepatocyte growth factor receptor substrate (Hrs) only modestly inhibits EGF degradation, does not induce tubulation of the early endosome, and causes the ..
  20. ncbi Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
    H Asao
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    J Biol Chem 272:32785-91. 1997
    ..The 110-kDa molecule was found to be a human counterpart of mouse Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and to be associated with STAM...
  21. pmc Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates
    Naomi Bishop
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Cell Biol 157:91-101. 2002
    ..Both tumor susceptibility gene 101 (TSG101)/human VPS (hVPS)28 and hepatocyte growth factor receptor substrate (Hrs) cytosolic complexes bind ubiquitin-agarose...
  22. ncbi STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
    Kristi G Bache
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Biol Chem 278:12513-21. 2003
    ..and STAM2, which have been identified as regulators of receptor signaling and trafficking, interact directly with Hrs, which mediates the endocytic sorting of ubiquitinated membrane proteins...
  23. pmc Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
    Kristi G Bache
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Cell Biol 162:435-42. 2003
    b>Hrs and the endosomal sorting complexes required for transport, ESCRT-I, -II, and -III, are involved in the endosomal sorting of membrane proteins into multivesicular bodies and lysosomes or vacuoles...
  24. ncbi Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15
    A J Bean
    Department of Neurobiology and Anatomy, and The W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 275:15271-8. 2000
    b>Hrs-2, via interactions with SNAP-25, plays a regulatory role on the exocytic machinery. We now show that Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis...
  25. ncbi The UIM domain of Hrs couples receptor sorting to vesicle formation
    Sylvie Urbé
    Physiological Laboratory, University of Liverpool, Crown St, Liverpool L69 3BX, UK
    J Cell Sci 116:4169-79. 2003
    Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs), a main component of the 'bilayered' clathrin coat on sorting endosomes, was originally identified as a substrate of activated tyrosine kinase receptors...
  26. ncbi Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    Yankun Li
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:28212-21. 2002
    ..Here we report that HAP1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a mammalian homologue of yeast vacuolar protein sorting protein Vps27p involved in the endosome-to-lysosome ..
  27. pmc TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
    Quan Lu
    Department of Genetics, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 100:7626-31. 2003
    ..Here we report that TSG101 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), an early endosomal protein, and that disruption of this interaction impedes endosomal trafficking and endocytosis-..
  28. ncbi The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
    Adriano Marchese
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Cell 5:709-22. 2003
    ..ubiquitin ligase AIP4 mediates ubiquitination of CXCR4 at the plasma membrane, and of the ubiquitin binding protein Hrs on endosomes. CXCR4 activation promotes CXCR4 colocalization with AIP4 and Hrs within the same region of endosomes...
  29. ncbi [A fulminating case of Edwardsiella tarda septicemia with necrotizing fasciitis]
    S Matsushima
    Clinical Research Institute, Yokohama National Hospital, Japan
    Kansenshogaku Zasshi 70:631-6. 1996
    ..His right leg became increasingly swollen with the development of edema and hemorrhagic bullae. About 4 hrs after the emergence of the skin lesion, his blood pressure fell to less than 60 mmHg...
  30. ncbi [Difference of host response in identical toxin-produced Staphylococcus aureus-injected mice]
    T Onogawa
    Department of Immunology, School of Health Sciences, Kyorin University
    Kansenshogaku Zasshi 72:536-42. 1998
    ..adhesion to surrounding organs and clearance period of bacterial cells from the liver, kidney and spleen within 24 hrs after intraperitoneal injection in the mice. All of them were weak or fast in KU-1-12-44 injected mice...
  31. ncbi Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection
    S Furue
    Discovery Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Crit Care Med 29:719-27. 2001
    ..and then were divided into the following groups: OA + vehicle groups, intravenous infusion of OA for the first 2 hrs (0...
  32. ncbi Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes
    J E Klaunig
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Toxicol Pathol 12:119-25. 1984
    ..After 24 hrs, cells were fixed and processed for autoradiography...
  33. ncbi [Effect of complement on the production of tumor necrosis factor alpha by human leukocytes with culture supernatants of clinical isolates of Staphylococcus aureus]
    N Endo
    Department of Immunology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 73:877-83. 1999
    ..One-tenth diluted solution of CS was added to Heparinized blood and was incubated for 6 hrs at 37 C in a 5% CO-air humidified incubator. TNF alpha level in the plasma was measured by ELISA...
  34. ncbi [Therapeutic effect of cefluprenam on polymicrobial urinary tract infection associated with Enterococcus faecalis, using the infectious urolithiasis model in rats]
    M Satoh
    Tokyo Research Laboratories, Eisai Co. Ltd
    Kansenshogaku Zasshi 72:371-8. 1998
    ..faecalis. The urinary excretion rates of CFLP and CAZ at rats were 59.3% and 59.4%, respectively, within 8 hrs after administration, showing a similar excretion pattern...
  35. ncbi Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells
    A B Deora
    Chemotherapy and Stem Cell Biology Division, Tata Memorial Center, Parel, Mumbai, India
    Tumori 83:756-61. 1997
    ..METHODS: K562 cells were treated with quercetin/genistein for a period of 72 hrs and then subjected to staining for apoptosis and erythroid differentiation and Western blotting with c-abl and ..
  36. ncbi Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines
    Heather Macarthur
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, MO, USA
    Crit Care Med 31:237-45. 2003
    ..Here we examined if maintenance of serum catecholamine levels by the superoxide dismutase mimetic, M40401, modulates serum cytokine levels and arterial hypotension in an Escherichia coli-infected conscious rat model of septic shock...
  37. ncbi A role of angiotensin-converting enzyme gene polymorphism in left ventricular remodeling after myocardial infarction
    Y He
    The First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 67:96-104. 2000
    ..three groups according to the change of end-diastolic volume index (EDVI)(Delta EDVI = EDVI 1 month-EDVI within 24 hrs); LVR(+) (Delta EDVI>7.0 ml/m(2), n = 5), LVR (-)(Delta EDVI<-7.0 ml/m(2), n = 13), and LVR (+/-)(-7...
  38. ncbi Phase II study of pentosan polysulfate (PPS) in patients with AIDS-related Kaposi's sarcoma
    G Schwartsmann
    Department of Medical Oncology, Academic Hospital of Porto Alegre (HCPA, Federal University of Rio Grande do Sul, Brazil
    Tumori 82:360-3. 1996
    ..PPS was administered at the dose of 25 mg/m2 q6 hrs at day 1, followed by 25 mg/m2 q12 hrs daily by a subcutaneous injection...
  39. ncbi Pathophysiologic role of oxygen-free radicals in toxic damage of the liver
    K Janicki
    1st Department of Surgery and Transplantology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:201-6. 2001
    ..The time of exposure was 12, 24 and 48 hrs, respectively. The control groups also contained 11 animals...
  40. ncbi Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats
    Robert W Hickey
    Division of Pediatric Emergency Medicine, Children s Hospital of Pittsburgh, PA 15213 2583, USA
    Crit Care Med 31:531-5. 2003
    ..We have previously reported in a rat model of asphyxial cardiac arrest that active warming, to prevent spontaneous hypothermia, worsens brain injury...
  41. ncbi [Effectiveness and hematotoxicity of paclitaxel monotherapy in patients with advanced non-small cell bronchial carcinoma (NSCLC)]
    M Leutz
    , Innere Medizin V, Homburg
    Pneumologie 51:62-5. 1997
    ..In these studies, paclitaxel was administered over 24 hrs. The aim of the present phase II clinical trial was to investigate the efficacy and the hematological toxicity of a ..
  42. ncbi [Myocardial infarction treated within 4 hrs: comparison of the cost-benefit ratio of 3 thrombolytic treatments: APSAC, rt-PA and streptokinase in 270 patients]
    J Machecourt
    Clinique cardiologique, CHU, Grenoble
    Arch Mal Coeur Vaiss 86:209-17. 1993
    ..abstract truncated at 250 words)..
  43. ncbi [Effects of intravenous nicardipine on blood pressure, hemorheology platelet function in arterial hypertension. Dose-effect relations]
    F Zannad
    , CHRU de Nancy,
    Arch Mal Coeur Vaiss 80:844-50. 1987
    ..These effects were dose-dependent with rapid onset and short duration (less than 2 hrs). NIC decreased plasma viscosity from 1.36 +/- 0.08 to 1.30 +/- 0.07 Cst; p less than 0...
  44. ncbi Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content
    B J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia 19104-6002
    Immunopharmacol Immunotoxicol 15:273-90. 1993
    ..GSH level and mercury exposure, T-cells, B-cells and monocytes were treated with different doses of HgCl2 for 12 hrs. All cells exhibited a dose-dependent decrease in GSH content with a concomitant reduction in GSSG levels...
  45. ncbi PSK and OK-432-induced immunomodulation of inducible nitric oxide (NO) synthase gene expression in mouse peritoneal polymorphonuclear leukocytes and NO-mediated cytotoxicity
    K Asai
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Immunopharmacol Immunotoxicol 22:221-35. 2000
    ..Six hrs after intraperitoneal injection of mice with PSK (2,500 microg/mouse) or OK-432 (100 microg/mouse), mouse ..
  46. ncbi [Effects of antiseptics against methicillin-resistant Staphylococcus aureus]
    Y Watanabe
    Department of Hospital Administration, Tokyo Medical College
    Kansenshogaku Zasshi 69:1235-43. 1995
    ..Though 0.2% povidone solution reduced MRSA under detection limits at 37, 24 hrs incubation, colonies of several strains were detected after 48 hrs extended incubation...
  47. ncbi [Inducibility of tumor necrosis factor alpha to peritoneal macrophages and lethality to mice of clinical isolates of Staphylococcus aureus]
    N Endo
    Department of Immunology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 72:231-7. 1998
    ..aureus (21 strains)(S. aureus-CS) for 4 hrs at 37 degrees C in a 5% CO2-air humidified incubator, TNF alpha induction from the treated cells was observed in 20/..
  48. ncbi The influence of blood glucose levels on [18F]fluorodeoxyglucose (FDG) uptake in cancer: a PET study in liver metastases from colorectal carcinomas
    F Crippa
    PET Unit, National Cancer Institute, Milan, Italy
    Tumori 83:748-52. 1997
    ..v. infusion of a glucose solution (4 mg/kg/min for 2 hrs)...
  49. ncbi The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock
    K Zacharowski
    William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Crit Care Med 29:1599-608. 2001
    ..Furthermore, we investigated whether ODQ scavenges superoxide anions and/or hydroxyl radicals...
  50. ncbi [Detection of verotoxin-producing Escherichia coli using polymerase chain reaction from dairy cattle]
    H Tada
    Tokushima Prefectural Institute of Public Health and Environmental Sciences
    Kansenshogaku Zasshi 66:1383-9. 1992
    ..All E. coli O157:H7 isolates failed to ferment after 48 hrs and to hydrolyze 4-methyl-umbelliferyl-beta-D-glucuronide (MUG)...
  51. ncbi Effect of dietary calcium, phosphate and vitamin D deprivation on the pharmacokinetics of 1,25-dihydroxyvitamin D3 in the rat
    M J Jongen
    Department of Biochemistry, University of California, Riverside
    Horm Metab Res 19:481-5. 1987
    ..04) (normal diet: 16.3 +/- 1.8 hrs, n = 6; -Ca diet: 18.6 +/- 1.1 hrs, n = 5; -P diet: 16.0 +/- 1.4 hrs, n = 6; mean +/- SD)...
  52. ncbi Further evidence that prolactin does not affect gonadotropin release at pituitary level
    W D Hetzel
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, , Germany
    Horm Metab Res 19:555-62. 1987
    ..of exogenous rPrl was studied at various concentrations (50-500 ng/ml) and with preincubation periods of 2 hrs and 6 hrs before starting LHRH stimulation...
  53. ncbi Induction of apoptosis in mouse thymocytes by cyclosporin A: in vivo study
    S Saiagh
    Laboratoire d'Immunologie, , Lyon, France
    Immunopharmacol Immunotoxicol 16:359-88. 1994
    ..DNA labeling with propidium iodide (PI) of thymocytes from CsA treated mice cultured for 24 hrs showed an increased number of apoptotic nuclei...
  54. ncbi Ifosfamide bolus followed by five days continuous infusion in extensively pretreated patients with advanced breast cancer: a phase II study
    G Bisagni
    Medical Oncology Service, General Hospital, Reggio Emilia, Italy
    Tumori 84:659-61. 1998
    ..Treatment consisted of ifosfamide infused at a dose of 2 g/m2 iv in 4 hrs followed by ifosfamide, 8 g/m2 iv in 120 hrs in ambulatory treatment, using a portable external pump system...
  55. ncbi Free radicals-induced morphological changes in the pancreas
    K Janicki
    1st Department of Surgery and Transplantology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:195-200. 2001
    ..The time of exposure was 12, 24 and 48 hrs, respectively. The animals were dissected immediately after decapitation...
  56. ncbi [Microabluminuria in arterial hypertension. Measurement, variables, interpretation, recommendations]
    A Hornych
    , , 96, rue Didot, 75674 Paris
    Arch Mal Coeur Vaiss 93:1304-8. 2000
    ..The definition of microalbuminuria is an urinary albumin excretion of 30-300 mg/24 hrs, confirmed on two occasions over a 3 month period...
  57. ncbi Hormones and hormone antagonists: mechanisms of action in carcinogenesis of endometrial and breast cancer
    T Flötotto
    University Hospital Dusseldorf, Department of Obstetrics and Gynaecology, Dusseldorf, Germany
    Horm Metab Res 33:451-7. 2001
    ..They mediate diverse physiological functions via interaction with nuclear-localised steroid hormone receptors (HRs)...
  58. ncbi Prevention of acquired infections in intubated patients with the combination of two decontamination regimens
    Christophe Camus
    Service de Maladies Infectieuses et Reanimation Medicale, Hopital de Pontchaillou, 2 rue Henri Le Guillous, 35033 Rennes Cedex, France
    Crit Care Med 33:307-14. 2005
    ..aureus. Because these two regimens could have a complementary role, we evaluated their effects when given both alone and combined...
  59. ncbi Hematopoietic growth factor receptors
    M F Brizzi
    Dipartimento di Scienze Biomediche e Oncologia Umana, , Italy
    Int J Cell Cloning 9:274-300. 1991
    ..that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK)...
  60. ncbi Laxation of critically ill patients with lactulose or polyethylene glycol: a two-center randomized, double-blind, placebo-controlled trial
    Johan I van der Spoel
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 35:2726-31. 2007
    ..To study whether lactulose or polyethylene glycol is effective to promote defecation in critically ill patients, whether either of the two is superior, and whether the use of enteral laxatives is related to clinical outcome...
  61. ncbi [An ATP bioluminescence assay for the analysis of bacterial biofilms]
    T Takenaka
    Department of Urology, Okayama University Medical School
    Kansenshogaku Zasshi 68:759-66. 1994
    ..The activity of the biofilm, assayed by ATP luminescence, increased rapidly during the first 4 hrs of circulation, and essentially remained unchanged for 32 hrs during medium circulation...
  62. ncbi Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Crit Care Med 27:1517-23. 1999
    ..In the third and fourth groups, rats received ip administration of 3-aminobenzamide (10 mg/kg) 1 and 6 hrs after zymosan or saline administration, respectively...
  63. ncbi [Comparison of the hemodynamic effects of dobutamine and enoximone in the treatment of low cardiac output after valvular surgery]
    M George
    , , Lyon
    Arch Mal Coeur Vaiss 83:57-62. 1990
    ..The duration of treatment was significantly shorter in Group E than in Group D (59 +/- 22 hrs vs 86 +/- 49 hrs) as was the patient's stay in the intensive care unit (92 +/- 37 hrs vs 155 +/- 129 hrs)...
  64. ncbi [Arrhythmia in patients with low cardiac output after valvular surgery. Randomized, double-blind comparative study of dobutamine versus enoximone]
    G Atallah
    Centre de lecture Holter-ECG, Lyon
    Arch Mal Coeur Vaiss 83:63-8. 1990
    ..Holter ECG monitoring over 42.65 +/- 6.02 hrs (24-48 hours) was obtained and interpreted blindly in 37/40 patients (19 Group D and 18 Group E)...
  65. ncbi Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device. II. Evaluation in animals
    F S Keck
    Abteilung Innere Medizin, , Germany
    Horm Metab Res 24:492-3. 1992
    ..92) up to a time period of 6 hrs. The "relative recovery" rate of glucose by the microdialysis probe in the SC tissue varied within the 6 ..
  66. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
    ..FGF(1/2) dose was 3 microg per i.v. injection given 24 and 4 hrs before the first radiation dose...
  67. ncbi [Effect of biological response modifiers against pulmonary candidiasis in neutropenic mice]
    M Futenma
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 68:513-9. 1994
    ..The histopathological investigations in our experiments showed that the assembly of PMNs to the infected lung at 24 hrs after bacterial challenge was more remarkable in the rhG-CSF treated mice than that in the vehicle alone...
  68. ncbi Early antibacterial effect of Pd-Ag dental alloy on aerobic and microaerophilic flora in oral cavity
    J Stipetić
    Department of Fixed Prosthodontics, School of Dental Medicine, University of Zagreb
    Coll Antropol 22:31-8. 1998
    ..Both were kept in a thermostat for 24 and 48 hrs and after that were examined for bacterial dehydrogenic activity to reveal the amount of active bacteria in a ..
  69. ncbi Effect of oral vs. parenteral cyclophosphamide on in vitro IgA and IgG production by murine Peyer's patches and cultured jejunal fragments
    J J Karacic
    Department of Medicine, University of Iowa College of Medicine, Iowa City 52242
    Immunopharmacol Immunotoxicol 9:441-65. 1987
    ..Mitogen induced secretion of IgA and IgG by Peyer's patch cells was markedly decreased 24 hrs after drug administration, with significant recovery by day 7...
  70. pmc Long-term exposure to constituents of fine particulate air pollution and mortality: results from the California Teachers Study
    Bart Ostro
    California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, Oakland, California 94612, USA
    Environ Health Perspect 118:363-9. 2010
    ..However, the health impacts of long-term exposure to specific constituents of PM(2.5) (PM with aerodynamic diameter < or = 2.5 microm) have not been explored...
  71. ncbi Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children
    Alexander R Santos
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Pediatr Crit Care Med 8:465-9. 2007
    ..To determine whether inhaled steroid administration after cardiopulmonary bypass will attenuate pulmonary inflammation and improve lung compliance and oxygenation...
  72. ncbi Inducible nitric oxide synthase and heme oxygenase-1 in the lung during lipopolysaccharide tolerance and cross tolerance
    Alexander Koch
    Molecular Cardioprotection and Inflammation Group, Department of Anesthesia, Bristol University, Bristol, UK
    Crit Care Med 35:2775-84. 2007
    ..We determined whether this occurs in the rat lung. The involvement of inducible nitric oxide synthase and heme oxygenase-1 was evaluated...
  73. ncbi [Local immunization against P. aeruginosa with an outer-membrane-protein vaccine]
    T Grundmann
    , Medizinische Hochschule Hannover
    Pneumologie 45:924-7. 1991
    ..clearance compared to nonimmunized controls, as indicated by bacterial counts from homogenized lung tissue taken 4 hrs after challenge. Thus, mucosal immunization with OMP vaccines might hinder initial colonisation of the lungs with P...
  74. ncbi [Epidemic of Salmonella enteritidis infection of childhood in the northern area of Nagasaki]
    M Matsuo
    Hokusho Central Hospital
    Kansenshogaku Zasshi 69:291-6. 1995
    ..S. enteritidis was identified from the ice cream which was also phage type 1. The latent period was 87 hrs.
  75. ncbi [Prevalence of obstruction of extrathoracic and intrathoracic airways in patients with arterial hypertension]
    J Fischer
    Klinik Norderney
    Pneumologie 47:151-4. 1993
    ..to frequency of oxygen desaturations measured according to frequency of oxygen desaturations measured during 8 hrs sleep (SaO2 > 90%, frequency > 80/8 hrs) and the Broca index (> 120%). 31.1% of the hypertensive and 16...
  76. pmc Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product
    Leonid V Omelyanchuk
    Institute of Cytology and Genetics, Russian Academy of Sciences, 10 Lavrent ev Ave, 630090, Novosibirsk, Russia
    Gene Regul Syst Bio 3:143-57. 2009
    Hepatocyte growth factor receptor tyrosine kinase substrate (HRS) is an endosomal protein required for trafficking receptor tyrosine kinases from the early endosome to the lysosome...
  77. ncbi Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from Swiss Webster mice
    M S Golub
    Department of Internal Medicine, School of Medicine, University of California, Davis 95616
    Immunopharmacol Immunotoxicol 15:605-19. 1993
    ..Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml)...
  78. ncbi [Histoenzymatic picture of rat gastric mucosa under the influence of dexamethasone]
    E Kifer Wysocka
    , Akademia Medyczna w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 46:143-8. 1991
    White male [correction of female] rats were given Dexamethasone in a single dose 0.35 mg/24 hrs. Group I was given the drug once, group II--received it for 2 days, and group III--for 7 days...
  79. ncbi Procalcitonin release patterns in a baboon model of trauma and sepsis: relationship to cytokines and neopterin
    H Redl
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Crit Care Med 28:3659-63. 2000
    ..We further hypothesized that in sepsis, PCT would be significantly different in survivors vs. nonsurvivors...
  80. ncbi Ifosfamide and etoposide in previously treated patients with advanced breast cancer
    S Kiraz
    Department of Medical Oncology, Hacettepe University, Ankara, Turkey
    Tumori 83:604-7. 1997
    ..The treatment schedule consisted of ifosfamide, 1500 mg/m2, infused over 24 hrs with 1500 mg/m2 mesna on days 1 to 5 and 120 mg/m2 etoposide, infused over 1 hr on days 1 to 3, to be repeated ..
  81. ncbi [Convulsive status epilepticus--clinical analysis of patients treated iin the Neurological Clinics, Medical Academy in Lublin in the years 1986-1995]
    B Chmielewska
    Katedra i Klinika Neurologii Akademii Medycznej w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 53:165-71. 1998
    ..Time to recovery varied from 0.5-2 (6%) to 2-6 or above 6 hrs (46% each) after continuous i.v. administration of BZD or chlormethiazole (53%) when ineffective...
  82. ncbi [Suppressive effect of lansoprazole on anti-Candida activity of murine macrophages]
    H Motegi
    Department of Internal Medicine, Teikyo University School of Medicine
    Kansenshogaku Zasshi 75:137-43. 2001
    ..When macrophages were preincubated with AG2000 for 1 hr and washed, their anti-Candida activity remained to be partially inhibited for 14 hrs. These results were discussed in relation to the pathogenesis of esophageal candidiasis.
  83. ncbi Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat
    S Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Crit Care Med 27:1524-32. 1999
    ..In the third and fourth groups, rats received ip administration of N-acetylcysteine (40 mg/kg; 1 and 6 hrs after administration of zymosan or saline)...
  84. ncbi The influence of agonists and antagonists of dopaminergic system on the formation of audiogenic seizures in rats during the ethanol abstinence period
    S Kaliszuk
    , Akademia Medyczna w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 45:163-7. 1990
    ..in the striatum occurring at ethanol abstinence increases and comes back again to its initial value after 18 or 48 hrs. Fadda et al...
  85. ncbi CD30 differential staining is useful in classifying lymphomas intermediate between Hodgkin's disease and anaplastic large cell (Ki1) lymphoma
    U Schmidt
    Department of Pathology, University of Essen, Germany
    Tumori 84:695-700. 1998
    ..Immunostaining was modified by pronase digestion and by microwave assistance. RESULTS: Hodgkin-Reed-Sternberg (HRS) cells of all 23 Hodgkin's lymphomas were reactive for BerH2, but the reactivity patterns differed: after pronase ..
  86. ncbi Pharmacokinetics of oral doxifluridine in patients with colorectal cancer
    M G Zampino
    Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 85:47-50. 1999
    ..AND STUDY DESIGN: Twenty colorectal cancer patients received levo-leucovorin, 25 mg orally on days 1-5, followed 2 hrs later by doxifluridine, 1200 mg/m2; the cycle was repeated every 10 days...
  87. ncbi Inactivation of Cu,Zn-superoxide dismutase by in vitro glycosylation and in erythrocytes of diabetic patients
    A Oda
    Department of Internal Medicine, University of Tsukuba, Japan
    Horm Metab Res 26:1-4. 1994
    ..dismutase was nonenzymatically glycosylated in vitro at a rate proportional to incubation time (2 to 120 hrs) and glucose concentration (10 to 100 mM)...
  88. ncbi [Hepatorenal syndrome]
    L Kuzela
    Department of Gastroenterology, Slovak Postgraduate Academy of Medicine, Bratislava
    Bratisl Lek Listy 101:639-44. 2000
    The association of renal failure with terminal liver insufficiency is referred to as hepatorenal syndrome (HRS)...
  89. ncbi [Protection of amrinone against lung injury induced by ischemia/reperfusion in rats]
    Su Gang Gong
    Department of Respiratory, Shanghai Pneumology Hospital, Shanghai 200433, China
    Zhongguo Dang Dai Er Ke Za Zhi 9:233-6. 2007
    ..To investigate the protective effect of amrinone against experimental lung ischemia /reperfusion (I/R) injury...
  90. ncbi Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, LeDucq Center for Molecular and Genetic Epidemiology, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 294:326-33. 2005
    ....
  91. pmc Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI
    Orly Lacham-Kaplan
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Reprod Biol Endocrinol 6:58. 2008
    ....
  92. ncbi [Effect duration and treatment effectiveness of salmeterol, fenoterol and salbutamol in severe forms of respiratory tract obstruction]
    M Vollmer
    Berufsgenossenschaftliche Kliniken Bergmannsheil,
    Pneumologie 49:528-34. 1995
    ..significant bronchodilation with all bronchodilator drugs after 15 min and maximum bronchodilation between 1 and 2 hrs. After 3 to 5 hrs...
  93. ncbi Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats
    J E Klebaur
    Department of Psychology, University of Michigan, Ann Arbor, USA
    Behav Pharmacol 12:267-75. 2001
    ..However, using the inescapable novelty test, both male and female HRs self-administered more amphetamine than LRs within the dose range tested (0.03-0.16 mg/kg/infusion)...
  94. ncbi [Effect of antibiotics and antibody on phagocytic bactericidal activity of polymorphonuclear neutrophils of Bordetella pertussis]
    H Muraoka
    Chemotherapy Division, Mitsubishi-Kagaku Bio-Clinical Laboratories
    Kansenshogaku Zasshi 73:239-43. 1999
    ..pertussis decreased to 1/1,000 1 hr after incubation and was not detected after 4 hrs. In particular, the viable cells of B...
  95. doi Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis
    Yasuyuki Susa
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Crit Care Med 37:2619-24. 2009
    ..Extracellularly released high mobility group-box 1 can bind to cell surface receptors, such as receptor for advanced glycation end-products, eliciting inflammatory responses that lead to the development of sepsis...
  96. ncbi Expression of c-myc and c-fos protooncogenes in the anterior pituitary gland of the rat. Effect of estrogen
    I Szijan
    , , UBA, Argentina
    Horm Metab Res 24:154-7. 1992
    ..c-fos mRNA increased in the anterior pituitary gland and remained high throughout the experimental period (16 to 22 hrs)...
  97. pmc Time-dependent alterations in serum NO concentration after oral administration of L-arginine, L-NAME, and allopurinol in intestinal ischemia/reperfusion
    Amalia E Yanni
    Department of Science of Dietetics and Nutrition, Harokopio University of Athens, Athens, Greece
    Vasc Health Risk Manag 4:437-41. 2008
    ....
  98. ncbi Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis
    Lucinda K Barrett
    Wolfson Institute for Biomedical Research, and the Department of Medicine, University College London, London, UK
    Crit Care Med 35:2337-43. 2007
    ..We investigated whether a long-term rodent model of sepsis would produce changes in endogenous levels and pressor reactivity to exogenous norepinephrine and vasopressin comparable with those seen in septic patients...
  99. ncbi Simple clinical predictors may obviate urgent endoscopy in selected patients with nonvariceal upper gastrointestinal tract bleeding
    Joseph Romagnuolo
    Departments of Medicine and Biometry, Bioinformatics and Epidemiology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Arch Intern Med 167:265-70. 2007
    ..The aims of this study were to predict whether the modified BRS (mBRS) can predict (1) endoscopic high-risk stigmata (HRS) and (2) rebleeding and mortality.
  100. pmc Effects of glucosinolates and flavonoids on colonization of the roots of Brassica napus by Azorhizobium caulinodans ORS571
    K J O'Callaghan
    Plant Science Division, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Appl Environ Microbiol 66:2185-91. 2000
    ..High- and low-glucosinolate-seed (HGS and LGS) varieties exhibited a relatively low and high percentage of colonized lateral roots, respectively...
  101. pmc Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats
    Laszlo G Nöt
    Department of Cell Biology, Center for Cardiovascular Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Crit Care Med 38:562-71. 2010
    ..the effects of O-linked beta-N-acetylglucosamine (O-GlcNAc) levels on survival, inflammation, and organ damage 24 hrs after trauma-hemorrhage...

Research Grants139 found, 100 shown here

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. PROGRAM DEVELOPMENT CORE
    PERRY SINGLETON; Fiscal Year: 2009
    ..In fact based on tabulations from HRS "exit" interviews, 68% of elderiy homeowners at age 70 died as homeowners...
  3. New insights in mechanisms of renal injury
    Balakuntalam S Kasinath; Fiscal Year: 2013
    ..mesangial cells (GEC) will be incubated with high glucose, or , equimolar mannitol, or, 5 mM glucose for up to 48 hrs. Under these conditions the following studies will be done. A. Upstream regulators of GSK 3beta...
  4. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..IL-7, RANTES and BAFF are induced 337, 45, 128, 84 and 119 fold, respectively, in synchronously infected ECs by 24 hrs p.i...
  5. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag Parikh; Fiscal Year: 2009
    ..In these cases, the main differential is between type 1 hepatorenal syndrome (HRS) and acute tubular necrosis (ATN)...
  6. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag R Parikh; Fiscal Year: 2010
    ..In these cases, the main differential is between type 1 hepatorenal syndrome (HRS) and acute tubular necrosis (ATN)...
  7. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2010
    ..development of focal areas of increased vascular leakage to fluorecein-labeled 2x106 Dal dextran conjugate at 48 hrs post injection (Gao et al. Nature Medicine 2007, Appendix 1)...
  8. Role of the kallikrein-kinin system in diabetic retinopathy
    EDWARD FEENER; Fiscal Year: 2009
    ..development of focal areas of increased vascular leakage to fluorecein-labeled 2x106 Dal dextran conjugate at 48 hrs post injection (Gao et al. Nature Medicine 2007, Appendix 1)...
  9. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..We have also shown that: (i) cholangiocytes express all four subtypes of histamine receptors (HRs);and (ii) H1HR and H2HR stimulate cholangiocyte growth, whereas H3HR or H4HR inhibit biliary growth during ..
  10. Outpatient treatment for portal hypertension
    Elijah M Bolotin; Fiscal Year: 2010
    ..the development of life-threatening consequences, including bleeding esophageal varices and hepatorenal syndrome (HRS), pharmacological treatment options are severely limited...
  11. Geriatric Conditions and Disablement in the Older Adult Population
    Christine T Cigolle; Fiscal Year: 2013
    ..The proposed research will utilize unique longitudinal data from the Health and Retirement Study (HRS), a nationally-representative health interview survey, and data from the HRS supplemental Aging, Demographics, and ..
  12. Geriatric Conditions and Disablement in the Older Adult Population
    Christine T Cigolle; Fiscal Year: 2010
    ..The proposed research will utilize unique longitudinal data from the Health and Retirement Study (HRS), a nationally-representative health interview survey, and data from the HRS supplemental Aging, Demographics, and ..
  13. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..proteins by immunohistochemistry (IHC), in selected regions of interest (ROIs) in animals subjected to 3 hrs of MCA occlusion with half of the animals treated with tPA and half without...
  14. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly Henrickson; Fiscal Year: 2009
    ..These new assays, in an integrated single device, may allow cost effective, point-of-care diagnosis within 1-2 hrs in an outpatient setting...
  15. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..These new assays, in an integrated single device, may allow cost effective, point-of-care diagnosis within 1-2 hrs in an outpatient setting...
  16. Mechanisms Underlying Adverse Cutaneous Effects Of The Anti-Cancer Drug.
    MELISSA ANN BROWN; Fiscal Year: 2012
    ..Thus, BZ must be delivered to cancer patients by i.v. injection every 72 hrs., a procedure that allows sustained targeting of the 26S proteasome activity. (2-4)...
  17. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ..IPSCs and EPSCs from brain slices during withdrawal from a single injection of ethanol administered to mice 24 hrs previous (non-dependent condition) or in mice consuming ethanol in the forced liquid ethanol diet procedure (..
  18. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..as opposed to pharmacological-mediated interventions) is that the window of opportunity can be as wide as 24-72 hrs, making them well-suited to the realities of when patients with stroke present to health care facilities...
  19. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ..terminals (synaptosomes) from the RVM of rats that received an intraplantar injection of saline- or CFA four hrs, four days or two weeks earlier. The subtype of NMDA receptor will be determined using subunit specific antagonists...
  20. Insulin as a Regulator of Microvascular Exchange
    Virginia H Huxley; Fiscal Year: 2013
    ..insulin in the regulation of in situ microvascular exchange in Aim 1, when Ins+ is predicted to alter acutely (min-hrs) protein flux in males, not females...
  21. Integration of Feeding and Glucose Metabolism by the Circadian Gene Network
    JOSEPH T BASS; Fiscal Year: 2013
    ..has been the finding that core clock genes comprise a transcription-translation feedback loop oscillating every ~24 hrs in nearly all tissues in addition to the SCN...
  22. CARDIOVIRAL PROTEASES AND COMPARATIVE GENOME STRUCTURE
    Ann C Palmenberg; Fiscal Year: 2011
    ..It's the job of the first viral proteins produced in the first 2-3 hrs of infection, to shutoff essential host response systems...
  23. Application of hydrogen gas inhalation for prevention of lung ischemia/reperfusio
    Atsunori Nakao; Fiscal Year: 2010
    ..7%. Preliminary experiments were conducted using a rat orthotopic left lung transplantation model with 6 hrs of cold ischemic time...
  24. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    Klaus Rajewsky; Fiscal Year: 2010
    ..the most common lymphoma in the Western world, the malignant cells are the so-called Hodgkin and Reed-Sternberg (HRS) cells, comprising only a few percent of the lymphoma mass...
  25. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    FREDERICK WAYNE ALT; Fiscal Year: 2013
    ..the most common lymphoma in the Western world, the malignant cells are the so-called Hodgkin and Reed-Sternberg (HRS) cells, comprising only a few percent of the lymphoma mass...
  26. EGF/Gastrin for islet cell regeneration
    GERARDO M CASTILLO; Fiscal Year: 2010
    ..of this proposal is to formulate injectable native EGF and gastrin in a stable form with half-life of at least 24 hrs and would require only one injection every 2 days instead of frequent injections or infusion...
  27. Health and Retirement Survey for India
    David Bloom; Fiscal Year: 2009
    ..will be designed to collect information that is conceptually comparable to that of the Health and Retirement Study (HRS) and its sister surveys in Asia (i.e...
  28. Mechanisms for Cardiovascular Control Early in Diabetes
    Michael W Brands; Fiscal Year: 2010
    ..that for days-to-weeks while measuring renal blood flow, renal excretory function, and mean arterial pressure 24 hrs/day...
  29. Engineering and Evaluation of Human L-Methionase for Cancer Therapy
    Everett Stone; Fiscal Year: 2013
    ..clinical trials the bacterial enzyme was shown to have very poor pharmacological properties (t 1/2 in serum only 2 hrs) and was found to be highly immunogenic in primates eliciting severe adverse responses that resulted in ..
  30. Terlipressin in Hepatorenal Syndrome Type 1
    PETER TEUBER; Fiscal Year: 2005
    ..Placebo-Controlled, Multicenter Phase 3 Study of Intravenous Terlipressin in Patients with Hepatorenal Syndrome (HRS) Type 1...
  31. p75NTR Ligands for Treament of Traumatic Brain Injury
    STEPHEN MASSA; Fiscal Year: 2009
    ..Forced Swim Test) and memory (Morris Water Maze) behaviors in animals treated immediately, up to 24 hrs, or beginning 2 weeks following injury...
  32. Matrix Metalloproteinase Inhibitors in Stroke
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..3) To select promising agents that block the BBB and to measure the effect on stroke infarct size at 48 hrs when the damage is greatest...
  33. Mechanism of cold platelet clearance
    John Hartwig; Fiscal Year: 2009
    ..Aim 2 will determine: (1) if sialylation facilitates the survival of refrigerated (>48 hrs) galactosylated platelets;(2) identify platelet acceptor proteins for UDP-galactose and CMP-sialic acid;(3) ..
  34. Effectiveness of an Automated Walking Program Targeting Veterans with COPD
    Caroline R Richardson; Fiscal Year: 2013
    ..This research program addresses three HRS&D priority areas: 1) Access / Rural Health, 2) Care of Complex Chronic Conditions, and 3) Healthcare ..
  35. Effectiveness of an Automated Walking Program Targeting Veterans with COPD
    Caroline R Richardson; Fiscal Year: 2013
    ..This research program addresses three HRS&D priority areas: 1) Access / Rural Health, 2) Care of Complex Chronic Conditions, and 3) Healthcare ..
  36. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..neuronal cell death/apoptosis, and therefore resulted poor neurological functional evaluations within 72 hrs after SAH, is a determination factor, rather than cerebral vasospasm as we believed previously, for clinical ..
  37. Molecular Analysis of Receptor Retrograde Transport
    MAIKKE BEYER OHLSON; Fiscal Year: 2010
    ..After 72 hrs, the cells will be fixed, stained with antibodies against MPRs and the Golgi, imaged with a high throughput ..
  38. Measurement of health and disability trends, compression of morbidity aging study
    Somnath Chatterji; Fiscal Year: 2013
    ..comparable cross-national data that can be compared to efforts in the US such as the Health and Retirement Study (HRS)...
  39. Lifecourse Pathways to Racial Disparities in Late-Life Cognitive Impairment
    Zhenmei Zhang; Fiscal Year: 2011
    ..Data come from the Health and Retirement Study (HRS), an ongoing nationally representative, longitudinal survey of Americans 51 years of age and older and Aging, ..
  40. Towards improving the measurement of health and disability trends, the compressio
    Somnath Chatterji; Fiscal Year: 2010
    ..comparable cross-national data that can be compared to efforts in the US such as the Health and Retirement Study (HRS)...
  41. National Trends in Brain Health: a Follow-Up Study of CIND and Dementia in the US
    David R Weir; Fiscal Year: 2010
    ..team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource ..
  42. National Trends in Brain Health: a Follow-Up Study of CIND and Dementia in the US
    David Weir; Fiscal Year: 2009
    ..team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource ..
  43. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    ..concentrations of volatile anesthetic isoflurane were used to induce and maintain anesthesia for a period of 6 hrs. This anesthesia protocol did not cause hypoxia, changes in cortical cerebral blood flow (in infant rats), or shift ..
  44. Leukocyte Trafficking in Acute Renal Failure
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..endogenous DC A2aRs critically control the extent of IRI, administration of A2a-tolDCs (up to 7 days before or 6 hrs after injury) protects kidneys from IRI, A2a agonists block CN, and allogenic A2a-tolDCs block IRI...
  45. Genetic Pathways Directing Ventral Folding Morphogenesis in Mammalian Embryos
    ELIZABETH H LACY; Fiscal Year: 2013
    ..2 investigates whether a VE specific null allele of Bmp2 genetically interacts with null alleles of Gata4 and Hgs/Hrs, mutants known to also disrupt ventral folding morphogenesis...
  46. Pathways Linking Reduced Sleep Duration and Quality to Obesity Risk
    Esra Tasali; Fiscal Year: 2009
    ..5hrs in bed;"baseline"), 5days with short undisturbed sleep (4.5 hrs in bed;"short sleep") and 5 days of short sleep with experimental fragmentation of NREM sleep (4...
  47. China Health and Retirement Longitudinal Study
    YAOHUI contact ZHAO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is a growing need for a HRS-type survey in China. China has more elderly than any country in the world and is one of the fastest aging countries in the world today...
  48. NYU/UG Cardiovascular Research Training Institute Program
    GBENGA GODWIN OGEDEGBE; Fiscal Year: 2013
    ..The program will have two tracks - a Health Services Research (HRS) track and a Patient-Oriented Research (POR) track...
  49. Dopaminergic and glutamatergic mechanisms of cocaine addiction: sex differences
    WENDY JEAN LYNCH; Fiscal Year: 2010
    ..extended access cocaine self-administration and an extended abstinence period whereby rats will either have 2 hrs/access to a wheel or no access. Markers of dopamine (i.e...
  50. Francisella - ATII interactions in respiratory tularemia
    Thomas C Zahrt; Fiscal Year: 2013
    ..infection of Ft in other cell types including macrophages where host cytopathic effects are observed within 24 hrs. This proposal seeks to fill our current knowledge gap by investigating aspects of Ft interactions with primary ..
  51. SDF-1: A Diagnostic and Therapy-Specific Biomarker of AKI and CKD
    Christof Westenfelder; Fiscal Year: 2011
    ..chemokine Stromal Derived Factor-1 (SDF-1 or CXCL12) in the kidney;2nd, urinary SDF-1 levels rise dramatically at 2 hrs post AKI, and decline with recovery;and 3rd, because MSC express CXCR4, the SDF-1 receptor, high SDF-1 levels ..
  52. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..While some stroke survivors are able to tolerate one or 2-hrs of daily surface ES therapy, many are not able to tolerate the required 6-hrs...
  53. Longterm Impact of Natural Disasters on Disability and Health in Older Americans
    Theodore J Iwashyna; Fiscal Year: 2013
    ..combine the unique longitudinal resources of over 16,000 respondents in the linked Health and Retirement Study (HRS) / Medicare files with a newly constructed mapping of all FEMA disaster declarations between 1998 and 2012...
  54. Health and Retirement: Pathways to Preservation and Improvement
    GEMA ZAMARRO; Fiscal Year: 2010
    ..on middle-aged and elderly adults in three different settings: eight waves of the Health and Retirement Study (HRS) (United States);three waves of the English Longitudinal Study of Ageing (ELSA) (England);and two waves of the ..
  55. Modified DNA Aptamers and DNAzymes for Diagnosing TB in Resource-Poor Settings
    DAN FELDHEIM; Fiscal Year: 2013
    ..Collectively they are too expensive, too time consuming (24 hrs or more), require specialized equipment, expertise, and power, have low sensitivities (50% in the sputum smear test)..
  56. A Novel Intervention Strategy for Stroke with RTL Therapy
    Halina Offner; Fiscal Year: 2012
    ..5 hrs. The proposed studies will demonstrate the efficacy of RTL1000 in treatment of ischemic stroke, and its ability to ..
  57. Predictors and Targets of Response to Cytokine Antagonism in Depression
    Andrew H Miller; Fiscal Year: 2013
    ..This additional data was collected at baseline, 24 hrs after the first infusion and at Wek 8 of the 12 week trial...
  58. Causes and Consequences of Healthcare Efficiency
    Jonathan S Skinner; Fiscal Year: 2013
    ..To improve risk adjustment, we develop new health measures from the Health and Retirement Study (HRS) and Medicare. We also pilot patient-reported and biomarker-based measures of health in three sites across the U.S...
  59. China Health and Retirement Longitudinal Study
    YAOHUI ZHAO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is a growing need for a HRS-type survey in China. China has more elderly than any country in the world and is one of the fastest aging countries in the world today...
  60. Resolution of ozone induced lung injury requires gamma/delta T cells
    Joel A Mathews; Fiscal Year: 2013
    ..and repair in both Wt and TCR[unreadable]-/- mice will be compared, by exposing animals to either air or O3 for 72 hrs and then allowing them to recover...
  61. p75NTR Ligands for Treament of Traumatic Brain Injury
    Stephen M Massa; Fiscal Year: 2013
    ..Forced Swim Test) and memory (Morris Water Maze) behaviors in animals treated immediately, up to 24 hrs, or beginning 2 weeks following injury...
  62. Role of Aldosterone in Cardiac Remodeling
    Flora Sam; Fiscal Year: 2009
    ..calcium transients will be measured simultaneously in adult rat and mouse myocytes following short (min ) or long (hrs) term exposure to exogenous aldosterone in vitro...
  63. Functional Impairment from Stroke: an Exploratory Study of Disparities
    MEDELLENA MARIA GLYMOUR; Fiscal Year: 2010
    ..The Health and Retirement Study (HRS) is an ongoing, nationally representative study of Americans aged 50+ that routinely asks participants about ..
  64. Role of the kallikrein-kinin system in diabetic retinopathy
    EDWARD FEENER; Fiscal Year: 2009
    ..development of focal areas of increased vascular leakage to fluorecein-labeled 2x106 Dal dextran conjugate at 48 hrs post injection (Gao et al. Nature Medicine 2007, Appendix 1)...
  65. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2001
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  66. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2005
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  67. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2004
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  68. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2003
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  69. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2002
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  70. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2004
    ..and to determine b) if prophase cells, induced by hypothermia to revert to G2, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; and c) the etiology of chromosome segregation abnormalities in such revertants ..
  71. China Health and Retirement Longitudinal Study - Pilot
    YAOHUI ZHAO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): There is a growing need for a HRS-type survey in China. China has more elderly than any country in the world and is one of the fastest aging countries in the world today...
  72. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly L Rieder; Fiscal Year: 2010
    ..determine b) if prophase cells, induced by hypothermia to revert to 62, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25;&c) the etiology of chromosome segregation abnormalities in such revertants ..
  73. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2009
    ..determine b) if prophase cells, induced by hypothermia to revert to 62, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25;&c) the etiology of chromosome segregation abnormalities in such revertants ..
  74. FORMATION,INTERACTION & FUNCTION OF SPINDLE COMPONENTS
    Conly Rieder; Fiscal Year: 2007
    ..amp; to determine b) if prophase cells, induced by hypothermia to revert to 62, fail to re-enter mitosis after 24 hrs because they lack cyclin A or Cdc25; & c) the etiology of chromosome segregation abnormalities in such ..
  75. Homing of Stem Cells in Stroke Therapeutics
    Evan Snyder; Fiscal Year: 2009
    ..as opposed to pharmacological-mediated interventions) is that the window of opportunity can be as wide as 24-72 hrs, making them well-suited to the realities of when patients with stroke present to health care facilities...
  76. BIOMEDICAL BASIS OF INTRACYTOPLASMIC SPERM INJECTION (ICSI)
    Gerald Schatten; Fiscal Year: 2000
    ..Whereas no significant changes in VEGF or ANG-2 mRNAs were observed, ANG-1 mRNA decreased from 0 to 12 hrs and then increased 30-fold by 36 hrs...
  77. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2009
    ..While some stroke survivors are able to tolerate one or 2-hrs of daily surface ES therapy, many are not able to tolerate the required 6-hrs...
  78. Roles for Cbl and ESCRT Proteins in 5-HT Receptor Function
    John Raymond; Fiscal Year: 2009
    ..is based is that two key protein families known to be involved in degradation of growth factor receptors - Cbl and HRS - are critical mediators of recycling of 5-HT2A receptors. The first aim focuses on c-Cbl, and the second on HRS...