HES1

Summary

Gene Symbol: HES1
Description: hes family bHLH transcription factor 1
Alias: HES-1, HHL, HRY, bHLHb39, transcription factor HES-1, class B basic helix-loop-helix protein 39, hairy homolog, hairy-like protein
Species: human
Products:     HES1

Top Publications

  1. Hartman J, Muller P, Foster J, Wimalasena J, Gustafsson J, Strom A. HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1. Oncogene. 2004;23:8826-33 pubmed
  2. Johansson T, Lejonklou M, Ekeblad S, Stalberg P, Skogseid B. Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors. Horm Metab Res. 2008;40:354-9 pubmed publisher
    ..We investigated the expression of NOTCH1, HES1, HEY1 and ASCL1 in pancreatic endocrine tumors and compared the data to tumor phenotype including hormone ..
  3. Sang L, Coller H, Roberts J. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science. 2008;321:1095-100 pubmed publisher
    ..Increased expression of the gene encoding the basic helix-loop-helix protein HES1 was required for quiescence to be reversible, because HES1 prevented both premature senescence and inappropriate ..
  4. Muller P, Crofts J, Newman B, Bridgewater L, Lin C, Gustafsson J, et al. SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells. Breast Cancer Res Treat. 2010;120:317-26 pubmed publisher
    ..Taken together, we present here a novel transcriptional mechanism in regulating hormone-dependent cancer cell proliferation. ..
  5. Jiao J, Qin Z, Li S, Liu H, Lu Z. Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration. Oncol Rep. 2009;22:815-23 pubmed
    ..that Notch1 signaling pathway was activated in laryngeal carcinoma accompanied with up-regulation of Notch1 and Hes1 expression...
  6. Villaronga M, Lavery D, Bevan C, Llanos S, Belandia B. HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions. Oncogene. 2010;29:411-20 pubmed publisher
    ..These findings suggest that the polymorphism Leu94Met in HEY1 radically alters its biological activities and may affect oncogenic processes. ..
  7. Nakahara F, Sakata Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, et al. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood. 2010;115:2872-81 pubmed publisher
    Hairy enhancer of split 1 (Hes1) is a basic helix-loop-helix transcriptional repressor that affects differentiation and often helps maintain cells in an immature state in various tissues...
  8. Schreck K, Taylor P, Marchionni L, Gopalakrishnan V, Bar E, Gaiano N, et al. The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res. 2010;16:6060-70 pubmed publisher
    ..The Notch target Hes1, a repressive transcription factor, bound the Gli1 first intron, and may inhibit its expression...
  9. Harada K, Sato Y, Ikeda H, Hsu M, Igarashi S, Nakanuma Y. Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours. J Clin Pathol. 2013;66:386-91 pubmed publisher
    ..In this study, the role of the Notch1-Hes1 signalling axis in the histogenesis of biliary NETs was examined...

More Information

Publications116 found, 100 shown here

  1. Strom A, Castella P, Rockwood J, Wagner J, Caudy M. Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. Genes Dev. 1997;11:3168-81 pubmed
    ..These results suggest that post-translational inhibition of HES-1 is both essential for and partially mediates the induction of neurite outgrowth by NGF signaling. ..
  2. Iso T, Sartorelli V, Poizat C, Iezzi S, Wu H, Chung G, et al. HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol. 2001;21:6080-9 pubmed
    ..Thus, Notch signaling relies on cooperation between HES and HERP, two transcriptional repressors with distinctive repression mechanisms which, either as homo- or as heterodimers, regulate target gene expression. ..
  3. Gratton M, Torban E, Jasmin S, Theriault F, German M, Stifani S. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. Mol Cell Biol. 2003;23:6922-35 pubmed
    b>Hes1 is a mammalian basic helix-loop-helix transcriptional repressor that inhibits neuronal differentiation together with corepressors of the Groucho (Gro)/Transducin-like Enhancer of split (TLE) family...
  4. Liu J, Ye F, Chen H, Lu W, Zhou C, Xie X. Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors. Int J Gynecol Cancer. 2007;17:1293-9 pubmed
    Hairy and Enhancer-of-split homologues 1 and 5 (Hes1 and Hes5) are the basic helix-loop-helix transcriptional factors that negatively regulate the cell differentiation during embryogenesis...
  5. Kannan S, Fang W, Song G, Mullighan C, Hammitt R, McMurray J, et al. Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression. Blood. 2011;117:2891-900 pubmed publisher
    ..The Notch target Hairy/Enhancer of Split1 (HES1) is sufficient to reproduce this tumor suppressor phenotype in B-ALL; however, the mechanism is not yet known...
  6. Bae S, Bessho Y, Hojo M, Kageyama R. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development. 2000;127:2933-43 pubmed
    ..Hes6 is expressed by both undifferentiated and differentiated cells, unlike Hes1, which is expressed only by the former cells...
  7. Tremblay C, Huang F, Habi O, Huard C, Godin C, Levesque G, et al. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008;112:2062-70 pubmed publisher
    ..pathway through a direct protein-protein interaction between the FA core complex and the hairy enhancer of split 1 (HES1). HES1 interaction with FA core complex members is dependent on a functional FA pathway...
  8. Wang X, Fu Y, Chen X, Ye J, Lu B, Ye F, et al. The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study. J Cancer Res Clin Oncol. 2010;136:989-96 pubmed publisher
    ..The aim of the study is to investigate significance of the expression of HES1/HES5 protein, downstream effectors of Notch, in prognosis of the patients with advanced ovarian epithelial cancers...
  9. Jin H, Xu J, Wang X, Ding Y. [Expression pattern and clinical significance of hairy enhancer of split 1 in colorectal cancer]. Zhonghua Yi Xue Za Zhi. 2011;91:2891-4 pubmed
    To explore the roles of hairy enhancer of split 1 (Hes1) gene in colorectal cancer and analyze its clinical significance. A total of 146 cases with colorectal cancer at our hospital were collected prospectively and followed up...
  10. Zhao N, Liao M, Wu J, Chu K. Curcumin suppresses Notch?1 signaling: Improvements in fatty liver and insulin resistance in rats. Mol Med Rep. 2017;: pubmed publisher
    ..The results of the present study suggest that the hepatic Notch?1 pathway can be suppressed via curcumin treatment, which may ameliorate fatty liver and insulin resistance in rats subjected to a high fat diet...
  11. Pan B, Wu L, Pan L, Yang Y, Li H, Dai Y, et al. Up-regulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway. Biosci Rep. 2018;38: pubmed publisher
    ..Expression of Notch, CTNNB1, hairy and enhancer of split 1 (Hes1), Bcl-2, Runt-related transcription factor 2 (Runx2), and osteocalcin increased and that of miR-340, Bcl-2 ..
  12. Kwon Y, Sasaki R, Meyer K, Ray R. Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis. J Virol. 2017;91: pubmed publisher
    ..analysis suggested that the antiapoptosis Bcl2 protein, proliferation-related cyclin D1 protein, and CSC-associated Hes1, Notch1, Nanog, and Sox2 proteins are enhanced during infection or ectopic expression of HCV core protein...
  13. Benn A, Hiepen C, Osterland M, Schütte C, Zwijsen A, Knaus P. Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. FASEB J. 2017;31:4720-4733 pubmed publisher
    ..thereby promoting the expression of stalk cell-associated genes, such as hairy and enhancer of split 1 (HES1) and fms-like tyrosine kinase 1 (FLT1)...
  14. Jiang B, Lv Q, Wan W, Le L, Xu L, Hu K, et al. Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance. Food Funct. 2018;: pubmed publisher
    ..via the Akt/FoxO1 signalling pathway and are regulated by the transcription factors hairy and enhancer of split 1 (HES1) and small heterodimer partner (SHP)...
  15. Huang J, Shen X, Yue S, Zhu J, Gao F, Zhai Y, et al. Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury. Mol Med. 2014;20:448-55 pubmed publisher
    ..Unlike in controls, Ad-HO-1 BMMs increased the expression of Notch1, Hes1, phosphorylation of Stat3 and Akt in IR-stressed Nrf2-deficient livers as well as in lipopolysaccharide (LPS)-..
  16. Saponara E, Grabliauskaite K, Bombardo M, Buzzi R, Silva A, Malagola E, et al. Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas. J Pathol. 2015;237:495-507 pubmed publisher
    ..Finally, we identified a regulatory Hes1-Ptfa axis in the uninjured adult pancreas, activated by zymogen secretion...
  17. Xie F, Cai W, Liu Y, Li Y, Du B, Feng L, et al. Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling. Int J Mol Med. 2015;35:135-42 pubmed publisher
    ..Furthermore, western blot detected the protein expressions of Notch1, Hes1 and caspase-3...
  18. Choi J, Ting C, Trogrlic L, Milevski S, Familari M, Martinez G, et al. A role for smoothened during murine lens and cornea development. PLoS ONE. 2014;9:e108037 pubmed publisher
    ..expression of p57Kip2, c-Maf, E-cadherin and Pax6, reduced expression of FoxE3 and Ptch1 and decreased nuclear Hes1. There was normal G1-S phase but decreased G2-M phase transition at E16.5 and epithelial cell death from E14.5-E16...
  19. Otti G, Saleh L, Velicky P, Fiala C, Pollheimer J, Knöfler M. Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy. PLoS ONE. 2014;9:e112723 pubmed publisher
    ..Transfection of a Notch luciferase reporter and qPCR of the Notch target gene hairy and enhancer of split 1 (HES1) revealed an induction of canonical Notch activity during in vitro differentiation...
  20. Sharifi N, Souri E, Ziai S, Amin G, Amanlou M. Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay. Daru. 2013;21:74 pubmed publisher
    ..The ACE activity was evaluated by determining the hydrolysis rate of substrate, hippuryl-L-histidyl-L-leucine (HHL), using reverse phase high performance liquid chromatography (RP-HPLC)...
  21. Navarrete F, García Gutiérrez M, Laborda J, Manzanares J. Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam. Psychoneuroendocrinology. 2017;85:134-141 pubmed publisher
    ..receptor (NR3C1) and FK506 binding protein 5 (FKBP5) in the hippocampus (HIPP), and the transcription factors Hes1, Hes5 and Hey1 in the PVN, HIPP and amygdala (AMY) were carried out in Dlk2-/- and WT mice under basal ..
  22. Shi Y, Shu B, Yang R, Xu Y, Xing B, Liu J, et al. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. Stem Cell Res Ther. 2015;6:120 pubmed publisher
    ..of ESCs, the differentiation and migration of keratinocytes, and follicle regeneration by targeting c-Myc and Hes1, which ultimately lead to enhanced or delayed wound healing...
  23. Yuan Y, Rangarajan P, Kan E, Wu Y, Wu C, Ling E. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. J Neuroinflammation. 2015;12:11 pubmed publisher
    ..The results suggest that scutellarin regulates the activation of microglia via the Notch pathway and concurrently induces morphological and functional changes in activated microglia. ..
  24. Youngstrom D, Dishowitz M, Bales C, Carr E, Mutyaba P, Kozloff K, et al. Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice. Bone. 2016;91:64-74 pubmed publisher
    ..Expression of Jag1 and the Notch target genes Hes1 and Hey1 was downregulated in all Jag1 knockout mice...
  25. Fan Y, Gao X, Chen J, Liu Y, He J. HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway. J Neurosci. 2016;36:11362-11373 pubmed
    ..Notch signaling downstream gene Hes1 promoter-driven luciferase reporter gene assay and Western blotting showed that recombinant Tat or Tat-containing ..
  26. Zhao K, Wang Q, Wang Y, Huang K, Yang C, Li Y, et al. EGFR/c-myc axis regulates TGFβ/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas. Cancer Lett. 2017;406:12-21 pubmed publisher
    ..MiR-524-3p and miR-524-5p inhibited TGF/β, Notch and the Hippo pathway by targeting Smad2, Hes1 and Tead1, respectively; these pathways repressed their common downstream transcription factor, C-myc...
  27. Lu J, Zhang J, Kim K, Case T, Matusik R, Chen Y, et al. Human homolog of Drosophila Hairy and enhancer of split 1, Hes1, negatively regulates ?-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer. Mol Cancer. 2010;9:304 pubmed publisher
    ..To address this question, we studied the hypothesis that Hes1, human homolog of Drosophila Hairy and enhancer of split (Hes) 1, is a transcriptional repressor of ?-catenin ..
  28. Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, et al. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 2014;123:3932-42 pubmed publisher
    High levels of HES1 expression are frequently found in BCR-ABL(+) chronic myelogenous leukemia in blast crisis (CML-BC)...
  29. Chen X, Gong L, Ou R, Zheng Z, Chen J, Xie F, et al. Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752. Gynecol Oncol. 2016;140:537-44 pubmed publisher
    ..G2/M phase cell cycle arrest and apoptosis with down-regulation of Notch1 and its downstream effectors including Hes1, XIAP, c-Myc and MDM2 in a dose- and time-dependent manner...
  30. Kay S, Harrington H, Shepherd S, Brennan K, Dale T, Osborne J, et al. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt. PLoS Comput Biol. 2017;13:e1005400 pubmed publisher
    ..Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk...
  31. Okuhashi Y, Itoh M, Tohda S. Hedgehog Stimulation Suppresses Clonogenicity and Activates NOTCH Signalling in T-lymphoblastic Leukaemia Jurkat Cells. Anticancer Res. 2017;37:5005-5009 pubmed
    ..the levels of cleaved NOTCH1 fragment characteristic for NOTCH1 activation, and upregulated mRNA expression of HES1, while decreasing that of MYC in Jurkat cells. However, no such effects were observed in KOPT-K1 cells...
  32. Chen T, Li H, Yin Y, Zhang Y, Liu Z, Liu H. Interactions of Notch1 and TLR4 signaling pathways in DRG neurons of in vivo and in vitro models of diabetic neuropathy. Sci Rep. 2017;7:14923 pubmed publisher
    ..The results showed that high glucose induced not only Notch1 mRNA, HES1 mRNA, and TLR4 mRNA expression, but also Notch1 intracellular domain (NICD1) and TLR4 protein expression in DRG ..
  33. Zhang H, Jiang H, Chen L, Liu J, Hu X, Zhang H. Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells. Eur J Pharmacol. 2018;818:364-370 pubmed publisher
    ..Our study aims to explore the function of Notch1/HES1 pathway in the radioresistance of colorectal cancer (CRC)...
  34. Diedisheim M, Oshima M, Albagli O, Huldt C, Ahlstedt I, Clausen M, et al. Modeling human pancreatic beta cell dedifferentiation. Mol Metab. 2018;10:74-86 pubmed publisher
    ..expression of ?-cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3. FGF2-induced dedifferentiation was time- and dose-dependent and reversible upon wash-out...
  35. Manokawinchoke J, Sumrejkanchanakij P, Subbalekha K, Pavasant P, Osathanon T. Jagged1 inhibits osteoprotegerin expression by human periodontal ligament cells. J Periodontal Res. 2016;51:789-799 pubmed publisher
    ..Jagged1 significantly enhanced HES1 and HEY1mRNA expression in a dose-dependent manner...
  36. Ortiz Masiá D, Cosín Roger J, Calatayud S, Hernández C, Alós R, Hinojosa J, et al. M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn's Disease. J Crohns Colitis. 2016;10:582-92 pubmed publisher
    ..The effects of macrophages on the expression of hairy and enhancer of split-1 (HES1, the main target of Notch signalling) and intestinal alkaline phosphatase (IAP, enterocyte marker) in epithelial ..
  37. Berenstein R, Nogai A, Waechter M, Blau O, Kuehnel A, Schmidt Hieber M, et al. Multiple myeloma cells modify VEGF/IL-6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR-223. Mol Carcinog. 2016;55:1927-1939 pubmed publisher
    ..and MM-BMMSCs induced activation of notch amongst others via jagged-2/notch-2 leading to increased expression of Hes1, Hey2, or Hes5 in both cell types...
  38. Zarazaga L, Gatica M, Gallego Calvo L, Guzman J. The reproductive performance of female goats treated with melatonin is not improved after introduction to bucks displaying springtime sexual activity if these does are experiencing decreasing body weight/condition score. Anim Reprod Sci. 2017;179:57-66 pubmed publisher
    ..maintenance requirements so they would experience increasing BW and BCS; and 2) high BW/high BCS animals (N=29) (HHl group), which were fed 0.4 times their maintenance requirements so they would experience decreasing BW and BCS...
  39. Liu X, Yang B, Huang S, Wu C, Li X, Cheng S, et al. Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. PLoS Pathog. 2017;13:e1006542 pubmed publisher
    ..an important downstream effector of Notch signaling, the transcriptional regulator Hairy and Enhancer of Split 1 (Hes1) is essential for governing NPC fate and fetal brain development...
  40. Wölnerhanssen B, Moran A, Burdyga G, Meyer Gerspach A, Peterli R, Manz M, et al. Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals. Sci Rep. 2017;7:8174 pubmed publisher
    ..A, gut hormones, ?-defensin, mucin 2, Na+/glucose co-transporter 1 (SGLT1) and transcription factors, Hes1, HATH1, NeuroD1, and Ngn3, were determined...
  41. Coglievina M, Guarnaccia C, Pintar A, Pongor S. Different degrees of structural order in distinct regions of the transcriptional repressor HES-1. Biochim Biophys Acta. 2010;1804:2153-61 pubmed publisher
    ..We propose that order/disorder transitions in the different domains are associated not only with binding to DNA, but also with protein homo- and hetero-dimerization. ..
  42. Yu J, Jiang H, Zhan R. Aberrant Notch signaling in glioblastoma stem cells contributes to tumor recurrence and invasion. Mol Med Rep. 2016;14:1263-8 pubmed publisher
    ..Hence, the development of novel anti?cancer drugs targeting the Notch1 signaling pathway may be a promising strategy for curing glioblastoma. ..
  43. Vasconcelos F, Sessa A, Laranjeira C, Raposo A, Teixeira V, Hagey D, et al. MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis. Cell Rep. 2016;17:469-483 pubmed publisher
    ..These include regulators of the neural progenitor program, such as Hes1, Sox2, Id3, and Olig1...
  44. Xie J, Huo S, Li Y, Dai J, Xu H, Yin Z. Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Müller Cell Notch Signaling Pathway. Cell Transplant. 2017;26:967-982 pubmed publisher
    ..expression, by retinal cells, of Notch signaling pathway components (including Notch3, Notch4, DLL1, DLL4, Jagged1, Hes1, and Hes5) 2 weeks after the cell transplantation and that this effect persisted for a further 2 weeks...
  45. Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, et al. Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine. Cancer Res. 2017;77:3442-3454 pubmed publisher
    ..Here, we demonstrate that NSC-specific and CSC-specific roles of the stem cell transcription factor Hes1 in the intestine enable the feasibility of a specific cancer therapy...
  46. Shi L, Ma Y, Zheng C, Zhang Q. The effect of blocking Notch signaling by ?-secretase inhibitor on allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2017;98:32-38 pubmed publisher
    ..Our findings provide evidence that blocking Notch signaling by GSI offers high value in treating AR. ..
  47. Liao F, Tan L, Liu H, Wang J, Ma X, Zhao B, et al. Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway. Acta Pharmacol Sin. 2017;: pubmed publisher
    ..After the 10-d differentiation period, the expression levels of miR126, SSEA1, CD117, Sca1, Notch1 and Hes1 in ESCs were assessed...
  48. Wang L, Wu Q, Zhu S, Li Z, Yuan J, Yu D, et al. Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer. Am J Transl Res. 2017;9:5031-5039 pubmed
    ..RT-PCR and western blot analysis were performed, and CD44, HES1 and GLI1 expression was significantly decreased in DNER knockdown cells...
  49. Tian C, Yu Y, Jia Y, Zhu L, Zhang Y. HES1 activation suppresses proliferation of leukemia cells in acute myeloid leukemia. Ann Hematol. 2015;94:1477-83 pubmed publisher
    ..To address this issue, we compared the expression levels of its downstream effector HES1 and p21 in bone marrow mononuclear cells (BMNCs) from 30 newly diagnosed AML patients and three AML cell lines to ..
  50. Van Sinderen M, Oyanedel J, Menkhorst E, Cuman C, Rainczuk K, Winship A, et al. Soluble Delta-like ligand 1 alters human endometrial epithelial cell adhesive capacity. Reprod Fertil Dev. 2017;29:694-702 pubmed publisher
    ..the adhesive capacity of endometrial epithelial cells via downregulation of helix-loop-helix and hairy/enhancer of split family member HES1 mRNA. Thus, soluble DLL1 may serve as a suitable target or potential biomarker for receptivity.
  51. Hassan W, Yoshida R, Kudoh S, Motooka Y, Ito T. Evaluation of role of Notch3 signaling pathway in human lung cancer cells. J Cancer Res Clin Oncol. 2016;142:981-93 pubmed publisher
    ..Notch3 is mainly expressed in NSCLC, and the expression of Notch1, Hes1 and Jagged1 is affected by Notch3...
  52. Zhou J, Jain S, Azad A, Xu X, Yu H, Xu Z, et al. Notch and TGF? form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells. Cell Signal. 2016;28:838-49 pubmed publisher
    ..On the other hand, TGF? treatment increases the expression of Notch ligand Jagged1 and Notch target gene HES1 in EOC cells...
  53. Wirth M, Doescher J, Jira D, Meier M, Piontek G, Reiter R, et al. HES1 mRNA expression is associated with survival in sinonasal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:491-9 pubmed publisher
    ..Expression of NOTCH1, NOTCH3, HES1, HEY1, and JAG1 mRNA were measured by using quantitative real-time polymerase chain reaction (q-rtPCR)...
  54. Liu S, Mitra R, Zhao M, Fan W, Eischen C, Yin F, et al. The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development. Mol Cancer Ther. 2016;15:2977-2986 pubmed publisher
    ..which may consequently inhibit, as we hypothesize, the expression of NOTCH3 and its downstream signaling molecule HES1 in glioblastoma...
  55. Lan L, Jiang Y, Zhang W, Li T, Ying B, Zhu S. Expression of Notch signaling pathway during osteoarthritis in the temporomandibular joint. J Craniomaxillofac Surg. 2017;45:1338-1348 pubmed publisher
    ..Immunohistochemistry was carried out to characterize the expression of the Notch markers Notch1, Jagged1, Hes1, and Hes5...
  56. Grbavec D, Lo R, Liu Y, Stifani S. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Eur J Biochem. 1998;258:339-49 pubmed
    ..Taken together, these findings implicate TLE2 in transcriptional repression and define the structural elements that mediate transcriptional and protein-protein interaction functions of Groucho/TLE proteins. ..
  57. Farshbaf M, Lindberg M, Truong A, Bevens Z, Chambers E, Pournara A, et al. Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. PLoS ONE. 2015;10:e0134013 pubmed publisher
    ..Furthermore, we show that a mutant MAML1 that has decreased ubiquitination shows increased output from a HES1 reporter gene assay...
  58. Capodanno Y, Buishand F, Pang L, Kirpensteijn J, Mol J, Argyle D. Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells. Endocr Relat Cancer. 2018;25:131-144 pubmed publisher
    ..Here, we demonstrated that Notch-signalling-related genes (NOTCH2 and HES1) were overexpressed in INS CSC-like cells...
  59. Chen J, Tschudy Seney B, Ma X, Zern M, Liu P, Duan Y. Salvianolic acid B enhances hepatic differentiation of human Embryonic Stem cells via upregulation of WNT pathway and inhibition of Notch pathway. Stem Cells Dev. 2017;: pubmed publisher
    ..Notch receptors (Notch1, Notch3), Notch ligand (Jagged2), Notch receptor targets (Hes1, 5), were down-regulated in treated cells, suggesting that Notch pathway was inhibited...
  60. Qu X, Afelik S, Jensen J, Bukys M, Kobberup S, Schmerr M, et al. Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. Dev Biol. 2013;376:1-12 pubmed publisher
    ..endocrine target genes; on the other, Ngn3 cell-extrinsically promotes lateral signaling via the Dll1>Notch>Hes1 pathway which substantially limits its ability to sustain endocrine formation...
  61. Liu C, Xu X, Gao J, Zhang T, Yang Z. Hydrogen Sulfide Prevents Synaptic Plasticity from VD-Induced Damage via Akt/GSK-3β Pathway and Notch Signaling Pathway in Rats. Mol Neurobiol. 2016;53:4159-4172 pubmed publisher
    ..Hydrogen sulfide modulated the ratio of NMDAR 2A/2B and improved the synaptic plasticity via Akt/GSK-3β pathway and Notch signaling pathway in VD rats. ..
  62. Chen L, Fan G, Zhang Z, Zhang B, Yan Z, Li H, et al. [Effect of ADAM10 Inhibitor GI254023X on Proliferation and Apoptosis of Multiple Myeloma H929 Cells and Its Possible Mechanisms]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1628-32 pubmed publisher
    ..GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation. ..
  63. Dhanesh S, Subashini C, James J. Hes1: the maestro in neurogenesis. Cell Mol Life Sci. 2016;73:4019-42 pubmed publisher
    ..In this review, we focus on how a dynamic gene, Hes1, is involved in neurogenesis with the view of its regulation and functional implications...
  64. Chen X, Jiao J, He X, Zhang J, Wang H, Xu Y, et al. CHI3L1 regulation of inflammation and the effects on osteogenesis in a Staphylococcus aureus-induced murine model of osteomyelitis. FEBS J. 2017;284:1738-1747 pubmed publisher
    ..Our study showed that Notch1, Jagged1 and Hes1 expression significantly decreased in mice infected with S...
  65. Hu G, Zhou Y, Zhu Y, Zhou L, Ling R, Wu D, et al. Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma. Oncol Rep. 2017;38:2975-2984 pubmed publisher
    ..factor-A production, co-stimulated Notch pathway with high expression of Notch intracellular domain (NICD) and Hes1. Moreover, ESCC cells under NS increased the expression of vimentin, Snail, Slug and MMP9 proteins; while ..
  66. Feder J, Li L, Jan L, Jan Y. Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. Genomics. 1994;20:56-61 pubmed
    ..Here, we report the genomic cloning of the human hairy gene homolog (HRY). The coding region of the gene is contained within four exons...
  67. Duan L, De Vos P, Fan M, Ren Y. IkappaBalpha regulates Hes1 in osteoclast differentiation and resorption. Front Biosci (Elite Ed). 2010;2:1065-72 pubmed
    ..The resorption area was measured. NF-kappaB transcriptional activity was determined by EMSA. Hes1, DC-STAMP and MMP-9 mRNA expression levels were determined by RT-PCR...
  68. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, et al. Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 2011;46:191-202 pubmed publisher
    ..The present study aimed to elucidate the regulation of cell formation in the human small intestine using biopsy specimens collected from an entire individual small intestine by DBE...
  69. Tian Y, Wang W, Lu Q, Chen P, Ma K, Jia Z, et al. Cross-talk of SFRP4, integrin ?1?1, and Notch1 inhibits cardiac differentiation of P19CL6 cells. Cell Signal. 2016;28:1806-15 pubmed publisher
    ..In addition, the SFRP4 overexpression augmented Notch1 and HES1 production...
  70. Hidalgo Sastre A, Brodylo R, Lubeseder Martellato C, Sipos B, Steiger K, Lee M, et al. Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model. Am J Pathol. 2016;186:2934-2944 pubmed publisher
    ..b>Hes1, a key downstream target of the Notch signaling pathway, is expressed in the centroacinar compartment of the adult ..
  71. Coad R, Dutton J, Tosh D, Slack J. Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness. Biochem Cell Biol. 2009;87:975-87 pubmed publisher
    ..system and by the replacement of biliary epithelium with pancreatic tissue in mice lacking the transcription factor Hes1. In normal pancreatic development, Hes1 is known to repress endocrine cell formation...
  72. Zhang C, Wang S, Jin H. [Inhibitory effect and mechanism of (-)-epigallocatechin-3-gallate on HT29 and HCT-8 colorectal cancer cell lines and expression of HES1 and JAG1]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:636-9 pubmed
    ..of (-)-epigallocatechin-3-gallate (EGCG) on cancer cells line HCT-8 and HT29 and its influence on the expression of HES1 and JAG1...
  73. Bouffard F, Plourde K, Bélanger S, Ouellette G, Labrie Y, Durocher F. Analysis of a FANCE Splice Isoform in Regard to DNA Repair. J Mol Biol. 2015;427:3056-73 pubmed publisher
    ..This study highlights the importance of an efficient regulation of alternative splicing expression of FA genes for proper DNA repair. ..
  74. Yan Y, Kong L, Xia Y, Liang W, Wang L, Song J, et al. Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury. Brain Behav Immun. 2018;67:118-129 pubmed publisher
    ..Additionally, we found that Ost up-regulated the expression of self-renewal genes Notch 1 and Hes 1. However, when Notch activity was blocked by the ?-secretase inhibitor DAPT, the expression of Notch 1 and Hes 1 ..
  75. Persson P, Stockhausen M, Påhlman S, Axelson H. Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. Int J Oncol. 2004;25:1213-21 pubmed
    ..These results indicate that ubiquilin-1 plays an active role in the precise regulation of HASH-1 and of other tissue-specific bHLH proteins. ..
  76. Riccio O, van Gijn M, Bezdek A, Pellegrinet L, van Es J, Zimber Strobl U, et al. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep. 2008;9:377-83 pubmed publisher
    ..This conversion correlates with the loss of Hes1 expression and derepression of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2...
  77. Tremblay C, Huard C, Huang F, Habi O, Bourdages V, Levesque G, et al. The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. J Biol Chem. 2009;284:13384-95 pubmed publisher
    ..we reported that the FA core complex interacts with the transcriptional repressor Hairy Enhancer of Split 1 (HES1) suggesting that the core complex plays a role in transcription...
  78. Wang S, Lin X, Wang H, Qin Y, Chen L, Li J, et al. Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway. Oncotarget. 2015;6:36713-30 pubmed publisher
    Overexpression of the transcriptional factor Hes1 (hairy and enhancer of split-1) has been observed in numerous cancers, but the precise roles of Hes1 in epithelial-mesenchymal transition (EMT), cancer invasion and metastasis remain ..
  79. Roese Koerner B, Stappert L, Berger T, Braun N, Veltel M, Jungverdorben J, et al. Reciprocal Regulation between Bifunctional miR-9/9(?) and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation. Stem Cell Reports. 2016;7:207-19 pubmed publisher
    ..We found that miR-9/9(?) decreases Notch activity by targeting NOTCH2 and HES1, resulting in an enhanced differentiation...
  80. Bi Y, Min M, Shen W, Liu Y. Numb/Notch signaling pathway modulation enhances human pancreatic cancer cell radiosensitivity. Tumour Biol. 2016;37:15145-15155 pubmed
    ..Numb expression significantly increased with increasing radiation dose, whereas the expression of Hes1, Notch1, and Hes5 significantly decreased compared to non-irradiated cells (P < 0.05)...
  81. Macnamara C, Chaplain M. Spatio-temporal models of synthetic genetic oscillators. Math Biosci Eng. 2017;14:249-262 pubmed publisher
    ..In this paper we first present a model of the canonical GRN (the Hes1 protein) and show the effect of varying the spatial location of gene and protein production sites on the ..
  82. Shan N, Wahler J, Lee H, Bak M, Gupta S, Maehr H, et al. Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer. J Steroid Biochem Mol Biol. 2017;173:122-129 pubmed publisher
    ..The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NF?B, which are involved in breast cancer stem cell maintenance...
  83. Longabaugh W, Zeng W, Zhang J, Hosokawa H, Jansen C, Li L, et al. Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network. Proc Natl Acad Sci U S A. 2017;114:5800-5807 pubmed publisher
    ..1, GATA-3, and E2A, their interactions with Notch signaling, and roles of Runx1, TCF-1, and Hes1, providing bases for a comprehensively updated model of the T-cell specification gene regulatory network presented ..
  84. da Silva I, Montero Montero L, Martín Villar E, Martin Perez J, Sainz B, Renart J, et al. Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells. Sci Rep. 2017;7:6276 pubmed publisher
    ..Furthermore, these cells showed increased stem characteristics, as demonstrated by upregulation of Hes1, Sox2 and Oct3/4, and enrichment of CD44high/CD24median/low cells...
  85. Boareto M, Iber D, Taylor V. Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development. 2017;144:3465-3474 pubmed publisher
    ..Our analyses unveil key molecular interactions underlying NSC maintenance and mechanistic differences between embryonic and adult neurogenesis. Similar Notch and ID factor interactions may be crucial in other stem cell systems...
  86. Lu L, Yue S, Jiang L, Li C, Zhu Q, KE M, et al. Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway and Aggravates Hepatocellular Damage In Mouse Ischemic Livers. Hepatology. 2017;: pubmed publisher
    ..Unlike in the Notch1FL/FL controls, myeloid Notch1 ablation diminished hairy and enhancer of split-1 (Hes1) and augmented c-Jun N-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1), JNK, ..
  87. Mu Y, Zhang X, Fan W, Li X, Chen G, Chen J, et al. [Mechanism of Astragaloside prevents cholestatic liver fibrosis through inhibition of Notch signaling activation]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:575-582 pubmed publisher
    ..pathway was evaluated by analyzing expressions of Notch-1, -2, -3, -4, Jagged (JAG)1, Delta like (DLL)-1, -3, -4, Hes1, Numb and RBP-J?. Statistical analysis of variance analysis, q test, P < 0...
  88. Barøy T, Kresse S, Skårn M, Stabell M, Castro R, Lauvrak S, et al. Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model. Mol Cancer. 2014;13:93 pubmed publisher
    ..of LSAMP, mRNA expression profiling revealed consistent upregulation of the genes hairy and enhancer of split 1 (HES1), cancer/testis antigen 2 (CTAG2) and kruppel-like factor 10 (KLF10)...
  89. Hu M, Ou Yang H, Wu C, Qu S, Xu X, Wang P. Notch signaling regulates col1?1 and col1?2 expression in airway fibroblasts. Exp Biol Med (Maywood). 2014;239:1589-96 pubmed publisher
    ..Using gene reporter assays, site-directed mutagenesis, and ChIP assays, the role of Hes1 binding sites in both the mouse and human COL1A1 and COL1A2 promoters was investigated...
  90. Kolsi R, Fakhfakh J, Krichen F, Jribi I, Chiarore A, Patti F, et al. Structural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide. Carbohydr Polym. 2016;151:511-522 pubmed publisher
    ..43mgml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL)...
  91. Han S, Wu M, Nam B, Park J, Yoo T, Kang S, et al. PGC-1? Protects from Notch-Induced Kidney Fibrosis Development. J Am Soc Nephrol. 2017;28:3312-3322 pubmed publisher
    ..Chromatin immunoprecipitation assays revealed that the Notch target gene Hes1 directly binds to the regulatory region of PGC-1? Compared with Pax8-rtTA/ICN1 transgenic animals,..
  92. Uchibori M, Aoyama K, Ota Y, Kajiwara K, Tanaka M, Kimura M. A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect. Oncol Rep. 2017;38:2237-2242 pubmed publisher
    ..b>HES1 and HEY1 mRNA expression levels were lower in A465T than in WT cells...