hepatocyte growth factor

Summary

Gene Symbol: hepatocyte growth factor
Description: hepatocyte growth factor
Alias: DFNB39, F-TCF, HGFB, HPTA, hepatocyte growth factor, fibroblast-derived tumor cytotoxic factor, hepatocyte growth factor (hepapoietin A; scatter factor), hepatopoietin-A, lung fibroblast-derived mitogen
Species: human
Products:     hepatocyte growth factor

Top Publications

  1. Han J, Tsukada Y, Hara E, Kitamura N, Tanaka T. Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem. 2005;280:31548-56 pubmed
    b>Hepatocyte growth factor (HGF) has an anti-proliferative effect on many types of tumor cell lines and tumors in vivo...
  2. Bonay M, Boutten A, Leçon Malas V, Marchal J, Soler P, Fournier M, et al. Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema. BMC Pulm Med. 2005;5:13 pubmed
    ..b>Hepatocyte growth factor mRNA correlated negatively with FEV1 and the FEV1/FVC ratio both in emphysema patients and in smokers ..
  3. Straussman R, Morikawa T, Shee K, Barzily Rokni M, Qian Z, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487:500-4 pubmed publisher
    ..Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein ..
  4. Ma J, DeFrances M, Zou C, Johnson C, Ferrell R, Zarnegar R. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. J Clin Invest. 2009;119:478-91 pubmed publisher
    ..We also suggest that DATE may be used as a potential genetic marker to identify individuals with a higher risk of developing breast cancer. ..
  5. Sakai K, Nakamura T, Matsumoto K, Nakamura T. Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association. J Biol Chem. 2009;284:22491-9 pubmed publisher
    NK4, a fragment of hepatocyte growth factor (HGF), exerts bifunctional action as a competitive antagonist against HGF and its receptor c-Met and an angiogenesis inhibitor. Here we studied the anti-angiogenic mechanism of NK4...
  6. Rajpathak S, Wassertheil Smoller S, Crandall J, Liu S, Ho G. Hepatocyte growth factor and clinical diabetes in postmenopausal women. Diabetes Care. 2010;33:2013-5 pubmed publisher
    To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes...
  7. Kitajima Y, Ide T, Ohtsuka T, Miyazaki K. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. Cancer Sci. 2008;99:1341-7 pubmed publisher
    Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form...
  8. Yanovitch T, Li Y, Metlapally R, Abbott D, Viet K, Young T. Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. Mol Vis. 2009;15:1028-35 pubmed
    b>Hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (C-MET) genes have previously been reported to be associated with myopia in Asian family-based and case-control association studies, respectively...
  9. Xie Q, Bradley R, Kang L, Koeman J, Ascierto M, Worschech A, et al. Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma. Proc Natl Acad Sci U S A. 2012;109:570-5 pubmed publisher
    ..We investigated in vivo glioblastoma models characterized by hepatocyte growth factor (HGF) autocrine or paracrine activation, or by MET or EGFR amplification, for their susceptibility to MET ..

More Information

Publications63

  1. Gupta A, Karakiewicz P, Roehrborn C, Lotan Y, Zlotta A, Shariat S. Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer. Clin Cancer Res. 2008;14:7385-90 pubmed publisher
    b>Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that is involved in cancer growth, motility, invasion, and angiogenesis...
  2. Xie L, Bian L, Li Z, Li Y, Li Z, Li B. Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma. Ann Surg Oncol. 2010;17:1927-36 pubmed publisher
    b>Hepatocyte growth factor (HGF)-related E-cadherin expression and prognosis of patients with nasopharyngeal carcinoma (NPC) are not fully understood...
  3. Kemp L, Mulloy B, Gherardi E. Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. Biochem Soc Trans. 2006;34:414-7 pubmed
    The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration...
  4. Liu Y, Li Q, Zhu L. Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival. Tumori. 2012;98:105-12 pubmed publisher
    The hepatocyte growth factor (HGF)/c-Met signaling system has been implicated in the development and progression of colon cancer, but the relationship between the expression of HGF or c-MET and clinicopathologic features remains ..
  5. Okunishi K, Dohi M, Fujio K, Nakagome K, Tabata Y, Okasora T, et al. Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J Immunol. 2007;179:5504-13 pubmed
    b>Hepatocyte growth factor (HGF) plays an important role in angiogenesis, cell proliferation, antifibrosis, and antiapoptosis...
  6. Balaban Y, Sumer H, Simsek H, Us D, Tatar G. Metabolic syndrome, non-alcoholic steatohepatitis (NASH), and hepatocyte growth factor (HGF). Ann Hepatol. 2006;5:109-14 pubmed
    b>Hepatocyte growth factor (HGF) is not only an antiapoptotic and antifibrotic factor of liver, but it is also an adipokine...
  7. Han W, Yap M, Wang J, Yip S. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. Invest Ophthalmol Vis Sci. 2006;47:2291-9 pubmed
    To investigate the association of high myopia with polymorphisms in the hepatocyte growth factor (HGF) gene, a potential candidate for myopia development...
  8. Ruggeri R, Sciacchitano S, Vitale A, Cardelli P, Galletti M, Vitarelli E, et al. Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals. J Endocrinol Invest. 2009;32:465-9 pubmed publisher
    ..Some growth factors and cytokines are known to cooperate with TSH in thyroid nodular growth, but few data are available on their circulating levels in Hashimoto's thyroiditis (HT)...
  9. Panganiban R, Day R. Hepatocyte growth factor in lung repair and pulmonary fibrosis. Acta Pharmacol Sin. 2011;32:12-20 pubmed publisher
    ..b>Hepatocyte growth factor (HGF) is a pleiotropic factor, which induces cellular motility, survival, proliferation, and ..
  10. Lindemann K, Resau J, Nahrig J, Kort E, Leeser B, Annecke K, et al. Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue. Histopathology. 2007;51:54-62 pubmed
    ..Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by ..
  11. Ohnishi H, Oka K, Mizuno S, Nakamura T. Identification of mannose receptor as receptor for hepatocyte growth factor ?-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis. J Biol Chem. 2012;287:13371-81 pubmed publisher
    b>Hepatocyte growth factor (HGF), a heterodimer composed of the ?-chain and ?-chain, exerts multifunctional actions for tissue repair and homeostasis via its receptor, MET...
  12. Burdon K, Macgregor S, Bykhovskaya Y, Javadiyan S, Li X, Laurie K, et al. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus. Invest Ophthalmol Vis Sci. 2011;52:8514-9 pubmed publisher
    ..Tag SNPs around the hepatocyte growth factor (HGF) gene were typed in three additional replication cohorts...
  13. Grotegut S, Kappler R, Tarimoradi S, Lehembre F, Christofori G, von Schweinitz D. Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. Int J Oncol. 2010;36:1261-7 pubmed
    b>Hepatocyte growth factor/scatter factor (HGF) is a ubiquitously expressed molecule that elicits pleiotropic functions on epithelial cells, including mitogenic, motogenic, differentiating, angiogenic and morphogenic effects...
  14. Li juan B, Bing L, Zhi L, Yang L, Ying jie L. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. Pathol Res Pract. 2009;205:828-37 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a multifunctional cytokine, but cell apoptosis related to HGF in nasopharyngeal carcinoma (NPC) and the potential mechanisms involved have not yet been identified...
  15. Atta H, Al Hendy A, Salama S, Shaker O, Hammam O. Low-dose simultaneous delivery of adenovirus encoding hepatocyte growth factor and vascular endothelial growth factor in dogs enhances liver proliferation without systemic growth factor elevation. Liver Int. 2009;29:1022-30 pubmed publisher
    b>Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) gene transfer proved to enhance liver regeneration...
  16. Kajiya K, Hirakawa S, Ma B, Drinnenberg I, Detmar M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005;24:2885-95 pubmed
    ..versus blood vascular endothelial cells (BVEC) revealed that LEC express significantly higher levels of hepatocyte growth factor receptor (HGF-R)...
  17. Ramos Nino M, Blumen S, Sabo Attwood T, Pass H, Carbone M, Testa J, et al. HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. Am J Respir Cell Mol Biol. 2008;38:209-17 pubmed
    The ligand hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase, c-Met, are highly expressed in most human malignant mesotheliomas (MMs) and may contribute to their increased growth and viability...
  18. Sulpice E, Ding S, Muscatelli Groux B, Berge M, Han Z, Plouet J, et al. Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells. Biol Cell. 2009;101:525-39 pubmed publisher
    ..HGF (hepatocyte growth factor) is a pleiotropic cytokine that may promote VEGF-A-driven angiogenesis, although the signalling ..
  19. Tyan S, Kuo W, Huang C, Pan C, Shew J, Chang K, et al. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS ONE. 2011;6:e15313 pubmed publisher
    ..The expression level of hepatocyte growth factor (HGF) in these fibroblasts was positively correlated with their ability to enhance breast tumorigenesis ..
  20. Gherardi E, Sandin S, Petoukhov M, Finch J, Youles M, Ofverstedt L, et al. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A. 2006;103:4046-51 pubmed
    The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the multidomain structure and proteolytic mechanism of activation of plasminogen and other complex serine proteinases...
  21. Dudek K, Kornasiewicz O, Koziak K, Kotulski M, Kalinowski P, Zieniewicz K, et al. Clinical significance of lymphocytes hepatocyte growth factor mRNA expression in patients after liver transplantation. Transplant Proc. 2007;39:2788-92 pubmed
    b>Hepatocyte growth factor (HGF) plays a key role in the regulation of liver regeneration after hepatocyte damage. Changes in HGF gene expression reflect the status of the regeneration process...
  22. Finegold D, Schacht V, Kimak M, Lawrence E, Foeldi E, Karlsson J, et al. HGF and MET mutations in primary and secondary lymphedema. Lymphat Res Biol. 2008;6:65-8 pubmed publisher
    ..Recent observations suggested that hepatocyte growth factor/high affinity hepatocyte growth factor receptor (HGF/MET) were new candidate lymphedema genes...
  23. Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, et al. Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma. Cancer Sci. 2011;102:2164-71 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a multifunctional molecule that acts as mitogen, motogen, and/or morphogen in a variety of cells...
  24. Awadalla M, Thapa S, Burdon K, Hewitt A, Craig J. The association of hepatocyte growth factor (HGF) gene with primary angle closure glaucoma in the Nepalese population. Mol Vis. 2011;17:2248-54 pubmed
    Genetic variation in the hepatocyte growth factor (HGF) gene has recently been associated with hyperopia, which is a known risk factor for primary angle closure glaucoma (PACG)...
  25. Kirchhofer D, Lipari M, Santell L, Billeci K, Maun H, Sandoval W, et al. Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist. Proc Natl Acad Sci U S A. 2007;104:5306-11 pubmed
    b>Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity...
  26. Skibinski G, Elborn J, Ennis M. Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor. Am J Physiol Lung Cell Mol Physiol. 2007;293:L69-76 pubmed
    ..activity in cocultures and in fibroblast-conditioned medium was reduced by neutralizing antibody to hepatocyte growth factor (HGF) and HGF receptor c-met. Neutralizing antibodies to FGF-7 and IGF-1 had no effect...
  27. Navab R, Liu J, Seiden Long I, Shih W, Li M, Bandarchi B, et al. Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells. Neoplasia. 2009;11:1292-300 pubmed
    ..Met, the receptor for hepatocyte growth factor (HGF) is a receptor tyrosine kinase with demonstrated roles in regulating cellular proliferation, ..
  28. Li Y, Guessous F, Johnson E, Eberhart C, Li X, Shu Q, et al. Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. Lab Invest. 2008;88:98-111 pubmed
    The growth factor hepatocyte growth factor (HGF), also known as scatter factor, and its tyrosine kinase receptor c-Met play important roles in medulloblastoma malignancy...
  29. Singleton P, Salgia R, Moreno Vinasco L, Moitra J, Sammani S, Mirzapoiazova T, et al. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem. 2007;282:30643-57 pubmed
    ..In this study, we explored the regulation of hepatocyte growth factor (HGF)-mediated enhancement of EC barrier function via CD44 isoforms...
  30. Xu J, Gao M, Fan S, Meng Q, Goldberg I, Abounader R, et al. Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells. Oncogene. 2007;26:2925-38 pubmed
    The cytokine scatter factor (SF) (hepatocyte growth factor) transduces various biologic actions, including cell motility, invasion, angiogenesis and apoptosis inhibition...
  31. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, et al. Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension. 2006;47:742-51 pubmed
    ..To provide the new therapeutic options, we examined the effect of overexpression of hepatocyte growth factor (HGF) in the chronic stage of cerebral infarction by transferring the HGF gene into the brain using ..
  32. Basilico C, Arnesano A, Galluzzo M, Comoglio P, Michieli P. A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J Biol Chem. 2008;283:21267-77 pubmed publisher
    b>Hepatocyte growth factor (HGF) and its high affinity receptor, the tyrosine kinase Met, play a key role in embryo development and tumor invasion. Both HGF and Met are established targets for cancer therapy...
  33. Buchstein N, Hoffmann D, Smola H, Lang S, Paulsson M, Niemann C, et al. Alternative proteolytic processing of hepatocyte growth factor during wound repair. Am J Pathol. 2009;174:2116-28 pubmed publisher
    ..We examined expression, integrity, and function of the proteins in the hepatocyte growth factor (HGF)/c-Met signaling pathway in normally healing and non-healing human skin wounds...
  34. Tu H, Zhou Z, Liang Q, Li Z, Li D, Qing J, et al. CXCR4 and SDF-1 production are stimulated by hepatocyte growth factor and promote glioma cell invasion. Onkologie. 2009;32:331-6 pubmed publisher
    b>Hepatocyte growth factor (HGF) and its receptor play an important role in the formation and progression of glioma and can promote tumor proliferation...
  35. Holt R, Fagerli U, Baykov V, Rø T, Hov H, Waage A, et al. Hepatocyte growth factor promotes migration of human myeloma cells. Haematologica. 2008;93:619-22 pubmed publisher
    ..cell-derived growth factor-1alpha, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells...
  36. Reznik T, Sang Y, Ma Y, Abounader R, Rosen E, Xia S, et al. Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor. Mol Cancer Res. 2008;6:139-50 pubmed publisher
    ..factor receptor (EGFR) and c-Met are frequently coexpressed in cancers, including those associated with hepatocyte growth factor (HGF) overexpression, such as malignant astrocytoma...
  37. Nakamura T, Sakai K, Nakamura T, Matsumoto K. Hepatocyte growth factor twenty years on: Much more than a growth factor. J Gastroenterol Hepatol. 2011;26 Suppl 1:188-202 pubmed publisher
    ..1980s, the method for the cultivation of mature hepatocytes provided an opportunity for the discovery of hepatocyte growth factor (HGF) as a protein that is structurally and functionally different from other growth factors...
  38. Huang J, Dong B, Zhang J, Kong W, Chen Y, Xue W, et al. miR-199a-3p inhibits hepatocyte growth factor/c-Met signaling in renal cancer carcinoma. Tumour Biol. 2014;35:5833-43 pubmed publisher
    ..We found that the concentrations of serum hepatocyte growth factor (HGF), the ligand of c-Met receptor, were significantly elevated in RCC patients compared to healthy ..
  39. Huang S, Ouyang N, Lin L, Chen L, Wu W, Su F, et al. HGF-induced PKC? activation increases functional CXCR4 expression in human breast cancer cells. PLoS ONE. 2012;7:e29124 pubmed publisher
    ..Interaction between hepatocyte growth factor (HGF) and the Met receptor tyrosine kinase mediates development and progression of cancers...
  40. Watanabe T, Tsuda M, Makino Y, Ichihara S, Sawa H, Minami A, et al. Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines. Mol Cancer Res. 2006;4:499-510 pubmed
    Activation of the c-Met receptor tyrosine kinase through its ligand, hepatocyte growth factor (HGF), promotes mitogenic, motogenic, and morphogenic cellular responses...
  41. Veerappan S, Pertile K, Islam A, Schache M, Chen C, Mitchell P, et al. Role of the hepatocyte growth factor gene in refractive error. Ophthalmology. 2010;117:239-45.e1-2 pubmed publisher
    ..Several genetic loci have been associated with myopia but none to date have been reported for hypermetropia. We investigated the hepatocyte growth factor (HGF) as a candidate gene influencing these 2 refractive error states.
  42. Chen J, Chen H, Huang S, Lin J, Zheng Y, Xie M, et al. Endophenotyping reveals differential phenotype-genotype correlations between myopia-associated polymorphisms and eye biometric parameters. Mol Vis. 2012;18:765-78 pubmed
    ..in myopia-associated single nucleotide polymorphisms (SNPs) of the gap junction protein delta 2 (GJD2), insulin-like growth factor-1 (IGF1) and hepatocyte growth factor (HGF) genes in two geographically different Chinese cohorts.
  43. Wang P, Li S, Xiao X, Jia X, Jiao X, Guo X, et al. High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. Invest Ophthalmol Vis Sci. 2009;50:1546-51 pubmed publisher
    ..Reasonable criteria as well as replication should be the first priority for genetic association studies to avoid excessive expansion of false-positive results, especially for high myopia. ..
  44. Ruggeri R, Sciacchitano S, Trimarchi F, Barresi G, Trovato M. Expression of hepatocyte growth factor in Hashimoto's thyroiditis with nodular lesions. Eur J Histochem. 2007;51:193-8 pubmed
    ..b>Hepatocyte growth factor (HGF) is expressed in benign thyroid nodules and over-expressed in malignant thyroid nodules, ..
  45. Tolbert W, Daugherty Holtrop J, Gherardi E, Vande Woude G, Xu H. Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci U S A. 2010;107:13264-9 pubmed publisher
    b>Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, ..
  46. Rajpathak S, Wang T, Wassertheil Smoller S, Strickler H, Kaplan R, McGinn A, et al. Hepatocyte growth factor and the risk of ischemic stroke developing among postmenopausal women: results from the Women's Health Initiative. Stroke. 2010;41:857-62 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a potent angiogenic factor and may play a role in the development and progression of atherosclerotic lesions, the underlying mechanism of cardiovascular disease...
  47. Owen K, Qiu D, Alves J, Schumacher A, Kilpatrick L, Li J, et al. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. Biochem J. 2010;426:219-28 pubmed publisher
    HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity...
  48. Hu S, Duan H, Li Q, Yang Y, Chen J, Wang L, et al. Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage. Acta Pharmacol Sin. 2009;30:1415-20 pubmed publisher
    ..Transwell chamber assay also showed that HGF increases migration activity of endothelial cells. HGF may afford protection to vascular endothelial cells against gamma ray irradiation-induced damage. ..
  49. Vistoropsky Y, Trofimov S, Malkin I, Kobyliansky E, Livshits G. Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure. Ann Hum Biol. 2008;35:93-103 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a member of the adipocytokine family; it is implicated in tissue repair, regeneration, and angiogenesis...
  50. Goormachtigh G, Ji Z, Le Goff A, Fafeur V. Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF/SF-MET signaling. Biochem Biophys Res Commun. 2011;411:780-5 pubmed publisher
    ..protein for transmitting intracellular signals of the MET tyrosine kinase receptor activated by hepatocyte growth factor/scatter factor (HGF/SF)...
  51. Lee Y, Moon C, Lee S, Park H, Seoh J, Cho M, et al. Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction. Eur Respir J. 2012;40:424-35 pubmed publisher
    Apoptotic cell clearance by macrophages and neighbouring tissue cells induces hepatocyte growth factor (HGF) secretion. HGF plays a key role in alveolar epithelial regeneration and reconstruction after lung injury...
  52. Du T, Ju G, Wu S, Cheng Z, Cheng J, Zou X, et al. Microvesicles derived from human Wharton's jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor. PLoS ONE. 2014;9:e96836 pubmed publisher
    ..RNase pre-treatment abrogated all effects of MVs. In summary, induction of HGF synthesis via RNA transferred by MVs activating AKT and ERK1/2 signaling is one of crucial contributors to the pro-tumor effect. ..
  53. Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Fujikawa H, Matsushita K, et al. Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy. Int J Oncol. 2012;40:583-91 pubmed publisher
    b>Hepatocyte growth factor (HGF) and its receptor cMET play an important role in tumor proliferation, invasion and metastasis...
  54. Xie L, Bian L, Li Z, Li Y, Liang Y. Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. Oncol Rep. 2010;23:141-50 pubmed
    b>Hepatocyte growth factor (HGF) related tumor angiogenesis and prognosis of patients with nasopharyngeal carcinoma (NPC) has not been identified...