Gene Symbol: HELZ2
Description: helicase with zinc finger 2
Alias: PDIP-1, PRIC285, helicase with zinc finger domain 2, ATP-dependent helicase PRIC285, PDIP1, PPAR gamma DBD-interacting protein 1, PPAR-alpha-interacting complex protein 285, PPAR-gamma DNA-binding domain-interacting protein 1, PPARG-DBD-interacting protein 1, PPARgamma-DNA-binding domain-interacting protein1, PRIC complex, helicase with zinc finger 2, transcriptional coactivator, peroxisomal proliferator-activated receptor A interacting complex 285, peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein, peroxisomal proliferator-activated receptor alpha-interacting cofactor complex, 285 kD subunit
Species: human
Products:     HELZ2

Top Publications

  1. Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, et al. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Endocrinology. 2006;147:377-88 pubmed
    ..PPARalpha and termed PPARalpha-interacting cofactor 285 (here referred to as PPARgamma-DBD-interacting protein 1 (PDIP1)-alpha). PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages...
  2. Pils D, Tong D, Hager G, Obermayr E, Aust S, Heinze G, et al. A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium. BMC Cancer. 2013;13:178 pubmed publisher
    ..analysis of microarrays yielded 13 genes (AP2A1, B4GALT1, C1orf63, CCR2, CFP, DIS3, NEAT1, NOXA1, OSM, PAPOLG, PRIC285, ZNF419, and BC037918) which were finally used in 343 samples (90 healthy, six cystadenoma, eight low malignant ..
  3. Huang C, Huang C. DnaT is a PriC-binding protein. Biochem Biophys Res Commun. 2016;477:988-992 pubmed publisher
    ..In addition, this DnaT-PriC complex could be co-purified by the heparin HP column...
  4. Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi A, Kashireddy P, et al. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci U S A. 2002;99:11836-41 pubmed
    ..The liganded PPAR alpha-PRIC complex enhanced transcription from a peroxisomal enoyl-CoA hydratase/l-3-hydroxyacyl-CoA dehydrogenase bifunctional ..
  5. Fairfax B, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet. 2012;44:502-10 pubmed publisher
    ..2, a known autoimmune disease locus, with IP6K2 (P = 5.8 × 10(-15)), PRIC285 (P = 3...
  6. Katano Toki A, Satoh T, Tomaru T, Yoshino S, Ishizuka T, Ishii S, et al. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Mol Endocrinol. 2013;27:769-80 pubmed publisher
    Using yeast two-hybrid screen, we previously isolated HELZ2 (helicase with zinc finger 2, transcriptional coactivator) that functions as a coregulator of peroxisome proliferator-activated receptor? (PPAR?)...