Genomes and Genes
Gene Symbol: HE6
Description: adhesion G protein-coupled receptor G2
Alias: CBAVDX, EDDM6, GPR64, HE6, TM7LN2, adhesion G-protein coupled receptor G2, G protein-coupled receptor 64, G protein-coupled receptor, epididymis-specific (seven transmembrane family), epididymal protein 6, human epididymis-specific protein 6
- Abe J, Fukuzawa T, Hirose S. Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site. J Biol Chem. 2002;277:23391-8 pubmed
- Peeters M, Fokkelman M, Boogaard B, Egerod K, van de Water B, IJzerman A, et al. The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFÎºB and is involved in cell adhesion and migration. Cell Signal. 2015;27:2579-88 pubmed publisher..ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male ..
- Balenga N, Azimzadeh P, Hogue J, Staats P, Shi Y, Koh J, et al. Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. J Bone Miner Res. 2017;32:654-666 pubmed publisher..Through gene expression profiling, we discovered that an orphan adhesion G protein-coupled receptor (GPCR), GPR64/ADGRG2, is expressed in human normal parathyroid glands and is overexpressed in parathyroid tumors from patients ..
- Obermann H, Samalecos A, Osterhoff C, Schröder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev. 2003;64:13-26 pubmedHuman Epididymis-specific protein 6 [HE6 (GPR64)] is a highly conserved, tissue-specific seven-transmembrane receptor of the human epididymis...
- Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, et al. Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. Am J Hum Genet. 2016;99:437-42 pubmed publisher..In men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect. ..
- Yoo J, Ahn J, Kim T, Yu S, Ahn J, Lim J, et al. G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells. Sci Rep. 2017;7:5021 pubmed publisherAlthough GPR64 has an important role for male fertility, its physiological roles in the female reproductive system are still unknown...