Gene Symbol: HE6
Description: adhesion G protein-coupled receptor G2
Alias: CBAVDX, EDDM6, GPR64, HE6, TM7LN2, adhesion G-protein coupled receptor G2, G protein-coupled receptor 64, G protein-coupled receptor, epididymis-specific (seven transmembrane family), epididymal protein 6, human epididymis-specific protein 6
Species: human
Products:     HE6

Top Publications

  1. Osterhoff C, Ivell R, Kirchhoff C. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol. 1997;16:379-89 pubmed
    A novel gene product, HE6, showing homology to the seven transmembrane-domain (Tm7) receptor superfamily, has been cloned by differential screening from a human epididymal cDNA library...
  2. Whittier K, Boese E, Gibson Corley K, Kirby P, Darbro B, Qian Q, et al. G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. Acta Neuropathol Commun. 2013;1:66 pubmed publisher
    ..Distinct over-expressed GPCRs emerge; for example, LGR5 and GPR64 are significantly and uniquely over-expressed in the WNT subgroup of tumors, while PTGER4 is over-expressed in the ..
  3. Demberg L, Rothemund S, Schöneberg T, Liebscher I. Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Biochem Biophys Res Commun. 2015;464:743-7 pubmed publisher
    The epididymis-specific adhesion G protein-coupled receptor (aGPCR) GPR64/ADGRG2 has been shown to be a key-player in the male reproductive system...
  4. Jeon T, Yang H, Lee C, Oh S, Seo D, Baik I, et al. Electro-hyperthermia up-regulates tumour suppressor Septin 4 to induce apoptotic cell death in hepatocellular carcinoma. Int J Hyperthermia. 2016;32:648-56 pubmed publisher
    ..and growth suppression) was up-regulated, whereas a key regulator of invasiveness G-Protein coupled receptor 64 (GPR64) was repressed...
  5. Demberg L, Winkler J, Wilde C, Simon K, Schön J, Rothemund S, et al. Activation of Adhesion G Protein-coupled Receptors: AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES. J Biol Chem. 2017;292:4383-4394 pubmed publisher
    ..i>Stachel peptides derived from aGPCRs of subfamily VI (GPR110/ADGRF1, GPR116/ADGRF5) and subfamily VIII (GPR64/ADGRG2, GPR126/ADGRG6) are able to activate more than one member of the respective subfamily supporting their ..
  6. Bliss S, Paul S, Pobiarzyn P, Ayer S, Sinha G, Pant S, et al. Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment. Sci Rep. 2018;8:367 pubmed publisher
    ..Data analyses and gene validation identified three membrane proteins, TMEM98, GPR64 and FAT4...
  7. Zhang D, Sun Y, Ma M, Wang Y, Lin H, Li R, et al. Gq activity- and ?-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. elife. 2018;7: pubmed publisher
    ..arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR...
  8. Kirchhoff C, Osterhoff C, Pera I, Schroter S. Function of human epididymal proteins in sperm maturation. Andrologia. 1998;30:225-32 pubmed
    ..This method identified six human epididymal cDNAs, named HE1-HE6, which are derived from abundant epididymal mRNAs...
  9. Trusler O, Huang Z, Goodwin J, Laslett A. Cell surface markers for the identification and study of human naive pluripotent stem cells. Stem Cell Res. 2018;26:36-43 pubmed publisher
    ..and primed cells could be defined using a low/medium/high expression of the following antigens TRA-1-60, PCDH1, GPR64, MHC Class I, however these markers were more likely to display expression pattern differences between methods...

More Information


  1. Abe J, Fukuzawa T, Hirose S. Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site. J Biol Chem. 2002;277:23391-8 pubmed
  2. Peeters M, Fokkelman M, Boogaard B, Egerod K, van de Water B, IJzerman A, et al. The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration. Cell Signal. 2015;27:2579-88 pubmed publisher
    ..ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male ..
  3. Balenga N, Azimzadeh P, Hogue J, Staats P, Shi Y, Koh J, et al. Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. J Bone Miner Res. 2017;32:654-666 pubmed publisher
    ..Through gene expression profiling, we discovered that an orphan adhesion G protein-coupled receptor (GPCR), GPR64/ADGRG2, is expressed in human normal parathyroid glands and is overexpressed in parathyroid tumors from patients ..
  4. Obermann H, Samalecos A, Osterhoff C, Schröder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev. 2003;64:13-26 pubmed
    Human Epididymis-specific protein 6 [HE6 (GPR64)] is a highly conserved, tissue-specific seven-transmembrane receptor of the human epididymis...
  5. Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, et al. Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. Am J Hum Genet. 2016;99:437-42 pubmed publisher
    ..In men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect. ..
  6. Yoo J, Ahn J, Kim T, Yu S, Ahn J, Lim J, et al. G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells. Sci Rep. 2017;7:5021 pubmed publisher
    Although GPR64 has an important role for male fertility, its physiological roles in the female reproductive system are still unknown...