Gene Symbol: HDGFL3
Description: HDGF like 3
Alias: CGI-142, HDGF-2, HDGF2, HDGFRP3, HRP-3, hepatoma-derived growth factor-related protein 3, hepatoma-derived growth factor 2, hepatoma-derived growth factor, related protein 3
Species: human
Products:     HDGFL3

Top Publications

  1. Zhuang Z, Mei G, Liu W, Chen Y, Zeng J, Zhang W, et al. Hepatoma-derived growth factor-2 is highly expressed during development and in spinal cord injury. Mol Med Rep. 2015;12:6140-4 pubmed publisher
    ..01). In conclusion, the overexpression of HDGF‑2 in the embryonic spinal cord and injured spinal cord may be involved in fetal spinal cord development and repair of SCI, respectively. ..
  2. Wu H, Zeng H, Lam R, Tempel W, Amaya M, Xu C, et al. Structural and histone binding ability characterizations of human PWWP domains. PLoS ONE. 2011;6:e18919 pubmed publisher
    ..Furthermore, we determined the crystal structures of the BRPF1 PWWP domain in complex with H3K36me3, and HDGF2 PWWP domain in complex with H3K79me3 and H4K20me3...
  3. Yun H, Hong E, Lee S, Baek J, Lee C, Yim J, et al. Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation. Biochem Biophys Res Commun. 2013;439:333-9 pubmed publisher
    ..Therefore, the HRP-3/Nrf2/HO-1/ROS/p53/PUMA cascade is an essential feature of the A549 cell phenotype and a potential radiotherapy target, extending the range of targets in multimodal therapies against lung cancer. ..
  4. Cherepanov P, Devroe E, Silver P, Engelman A. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem. 2004;279:48883-92 pubmed
    ..LEDGF/p75 and HRP2 are predicted to share a similar domain organization and have an evident evolutionary and likely functional relationship. ..
  5. Vandegraaff N, Devroe E, Turlure F, Silver P, Engelman A. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 2006;346:415-26 pubmed
    ..We conclude that cells knocked-out for LEDGF/p75 and/or HRP2 will be useful genetic tools to address the roles of these host cell factors in HIV-1 replication. ..
  6. El Tahir H, Abouzied M, Gallitzendoerfer R, Gieselmann V, Franken S. Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons. J Biol Chem. 2009;284:11637-51 pubmed publisher
    ..This activity depends on the extranuclear localization of HRP-3. HRP-3 thus could play an important role during neuronal development by its modulation of the neuronal cytoskeleton. ..
  7. Cui H, Schlesinger J, Schoenhals S, Tönjes M, Dunkel I, Meierhofer D, et al. Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. Nucleic Acids Res. 2016;44:2538-53 pubmed publisher
    ..Thus, we present a novel pathway for pathological cardiac hypertrophy, whose inhibition is a long-term therapeutic goal for the treatment of the course of heart failure. ..
  8. Cai H, Jiang D, Qi F, Xu J, Yu L, Xiao Q. HRP-3 protects the hepatoma cells from glucose deprivation-induced apoptosis. Int J Clin Exp Pathol. 2015;8:14383-91 pubmed
    ..We propose that glucose deprivation-induced HRP-3 up-regulation potentially plays a major role in protecting HCC cells against apoptosis caused by energy pressure. ..
  9. Davila J, Starr J, Attia S, Wang C, Knudson R, Necela B, et al. Comprehensive Genomic Profiling of a Rare Thyroid Follicular Dendritic Cell Sarcoma. Rare Tumors. 2017;9:6834 pubmed publisher
    ..The fusion gene HDGFRP3?SHC4 led to a 200-fold increase in the expression of oncogene SHC4 which is a potential target of the commercial ..

More Information


  1. Ikegame K, Yamamoto M, Kishima Y, Enomoto H, Yoshida K, Suemura M, et al. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. Biochem Biophys Res Commun. 1999;266:81-7 pubmed
    ..These findings suggest that a new member of the HDGF gene family, HRP-3, may function mainly in the nucleus of the brain, testis, and heart, probably for cell proliferation. ..