Gene Symbol: HDGFL2
Description: HDGF like 2
Alias: HDGF-2, HDGF2, HDGFRP2, HRP-2, HRP2, hepatoma-derived growth factor-related protein 2, HDGF-related protein 2
Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, et al
. LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS Pathog. 2012;8:e1002558 pubmed publisher
..These results further support the potential of LEDGINs as allosteric integrase inhibitors. ..
Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci. 2005;118:1733-43 pubmed publisher
..LEDGF/p75 is a multidomain adaptor protein that interacts with the nuclear import apparatus, lentiviral IN proteins and chromatin by means of an NLS, an IBD and additional chromatin-interacting domains...
Vandegraaff N, Devroe E, Turlure F, Silver P, Engelman A. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 2006;346:415-26 pubmed
..growth factor (LEDGF) transcriptional coactivator/p75 and hepatoma-derived growth factor related protein 2 (HRP2) tightly bind to HIV-1 IN and stimulate its integration activity in vitro...
Izumoto Y, Kuroda T, Harada H, Kishimoto T, Nakamura H. Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997;238:26-32 pubmed
..HRP-1 is expressed specifically in testis. These findings suggest that the HDGF gene family might play a new role in the nucleus especially in testis. ..
Cherepanov P, Devroe E, Silver P, Engelman A. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem. 2004;279:48883-92 pubmed
..IBD) is not unique to LEDGF/p75, as a second human protein, hepatoma-derived growth factor-related protein 2 (HRP2), contains a homologous sequence...
Zhuang Z, Mei G, Liu W, Chen Y, Zeng J, Zhang W, et al
. Hepatoma-derived growth factor-2 is highly expressed during development and in spinal cord injury. Mol Med Rep. 2015;12:6140-4 pubmed publisher
..01). In conclusion, the overexpression of HDGFâ€‘2 in the embryonic spinal cord and injured spinal cord may be involved in fetal spinal cord development and repair of SCI, respectively. ..
Baude A, Aaes T, Zhai B, Al Nakouzi N, Oo H, Daugaard M, et al
. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 2016;44:2214-26 pubmed publisher
..that the structurally related PWWP domain-containing protein, hepatoma-derived growth factor-related protein 2 (HDGFRP2), serves a similar function in homologous recombination repair...
Schrijvers R, Vets S, De Rijck J, Malani N, Bushman F, Debyser Z, et al
. HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology. 2012;9:84 pubmed publisher
..Knockdown of HRP-2 upon LEDGF/p75 depletion results in a more random HIV-1 integration pattern. These data therefore reinforce the understanding that LEDGF/p75 is the dominant HIV-1 IN co-factor. ..
Hultquist J, Schumann K, Woo J, Manganaro L, McGregor M, DOUDNA J, et al
. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016;17:1438-1452 pubmed publisher
..This technology should accelerate target validation for pharmaceutical and cell-based therapies to cure HIV infection. ..