HDAC9

Summary

Gene Symbol: HDAC9
Description: histone deacetylase 9
Alias: HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, histone deacetylase 9, MEF-2 interacting transcription repressor (MITR) protein, histone deacetylase 4/5-related protein, histone deacetylase 7B
Species: human
Products:     HDAC9

Top Publications

  1. Bellenguez C, Bevan S, Gschwendtner A, Spencer C, Burgess A, Pirinen M, et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet. 2012;44:328-33 pubmed publisher
    ..We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21...
  2. Markus H, Mäkelä K, Bevan S, Raitoharju E, Oksala N, Bis J, et al. Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. Stroke. 2013;44:1220-5 pubmed publisher
    ..1 and large-vessel ischemic stroke was recently identified. The most likely underlying gene is histone deacetylase 9 (HDAC9)...
  3. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, et al. The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem. 2003;278:16059-72 pubmed
    ..We have now fully characterized a new member of the Class II HDAC family, HDAC9. The enzyme contains a conserved deacetylase domain, represses reporter activity when recruited to a promoter, and ..
  4. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  5. Traylor M, Farrall M, Holliday E, Sudlow C, Hopewell J, Cheng Y, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 2012;11:951-62 pubmed publisher
    ..and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)). Additionally, we verified that all associations were subtype specific...
  6. Miska E, Karlsson C, Langley E, Nielsen S, Pines J, Kouzarides T. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 1999;18:5099-107 pubmed
    ..These results identify MEF2A as a nuclear target for HDAC4-mediated repression and suggests that compartmentalization may be a novel mechanism for controlling the nuclear activity of this new family of deacetylases. ..
  7. Yan K, Cao Q, Reilly C, Young N, Garcia B, Mishra N. Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. J Biol Chem. 2011;286:28833-43 pubmed publisher
    Co-repressor histone deacetylase 9 (HDAC9) plays a key role in the development and differentiation of many types of cells, including regulatory T cells. However, the biological function of HDAC9 in T effector cells is unknown...
  8. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..In this work, the effects of an HDAC class I and II inhibitor trichostatin A (TSA) on the whole transcriptome of SK-MEL-3 cells carrying a BRAF mutation ..
  9. Lee T, Bai K, Chen Y, Lee T, Chung C, Tsai W, et al. Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. Mol Med Rep. 2017;: pubmed publisher
    ..Histone deacetylase (HDAC) inhibitors attenuate cardiac fibrosis and inflammation, and improve cardiomyopathy resulting from DM...

More Information

Publications140 found, 100 shown here

  1. Ruess D, Probst M, Marjanovic G, Wittel U, Hopt U, Keck T, et al. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0161233 pubmed publisher
    Histone deacetylases (HDAC) catalyze N-terminal deacetylation of lysine-residues on histones and multiple nuclear and cytoplasmic proteins...
  2. Lee H, Kang S, Kim M, Lee E, Cho H, Moon E, et al. Histone Deacetylase Inhibition Ameliorates Hypertension and Hyperglycemia in a model of Cushing's Syndrome. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00267.2017 pubmed publisher
    ..We hypothesized that HDAC inhibition (HDACi) decreased transcriptional activity of glucocorticoid receptor (GR), which ameliorates ..
  3. Lee H, Lee E, Do G, Moon E, Quan F, Kim I. Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death. Biomed Pharmacother. 2019;109:921-929 pubmed publisher
    Inhibition of histone deacetylase (HDAC) suppresses inflammation of pancreatic islets and apoptosis of β-cells. However, the underlying molecular mechanism is unclear...
  4. Feng Q, Su Z, Song S, Χu H, Zhang B, Yi L, et al. Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation. Int J Mol Med. 2016;38:812-22 pubmed publisher
    ..Histone deacetylase (HDAC) is an important epigenetic regulator in lung diseases...
  5. Ren B, Best B, Ramakrishnan D, Walcott B, Storz P, Silverstein R. LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming. Arterioscler Thromb Vasc Biol. 2016;36:1197-208 pubmed publisher
    ..Targeting this signaling cascade could be a novel approach for ischemic cardiovascular disease and cancer. ..
  6. Chen X, Xie X, Zhao Q, Wang F, Bai Y, Yin J, et al. Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells. Mol Med Rep. 2015;11:105-12 pubmed publisher
    ..The c-Myc/S-phase kinase-associated protein 2 (Skp2) and histone deacetylase (HDAC)1/2 pathways were found to exert an important role in AMP-induced A549 cell apoptosis, as increased levels of c-Myc ..
  7. Omar S, Scott C, Hamlin A, Obied H. Biophenols: Enzymes (?-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). Fitoterapia. 2018;128:118-129 pubmed publisher
    ..progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols...
  8. Chang M, Chen Y, Lian Y, Chang B, Huang C, Huang W, et al. Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells. Int J Mol Sci. 2018;19: pubmed publisher
    Butyric acid as a histone deacetylase (HDAC) inhibitor is produced by a number of periodontal and root canal microorganisms (such as Porphyromonas, Fusobacterium, etc.)...
  9. Sato A, Ueno H, Fusegi M, Kaneko S, Kohno K, Virgona N, et al. A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells. Pharmacology. 2018;102:26-36 pubmed publisher
    ..MM cells treated with Zebularine (a DNMT inhibitor) and sodium butyrate (an HDAC inhibitor) exhibited cytotoxic effects, which may explain the inhibitory action of T3E on MM cells...
  10. Zelko I, Folz R. Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. Am J Respir Cell Mol Biol. 2015;53:513-24 pubmed publisher
    ..artery endothelial cells (HPAECs) and human pulmonary artery smooth muscle cells were exposed to an array of HDAC inhibitors followed by analysis of anti- and prooxidant gene expression using quantitative RT-PCR and quantitative ..
  11. Zhang H, Du M, Yang Q, Zhu M. Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase. J Nutr Biochem. 2016;27:299-306 pubmed publisher
    ..In conclusion, butyrate inhibits cell proliferation and increases cell apoptosis in mastocytoma P815 cells and suppresses FcεRI-dependent cytokine production in murine primary BMMC, which are likely mediated by HDAC inhibition.
  12. Park M, Sohrabji F. The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflammation. 2016;13:300 pubmed
    Sodium butyrate (NaB) is a histone deacetylase (HDAC) inhibitor exhibiting anti-inflammatory and neuroprotective effects in a rat ischemic model of stroke as well as a myocardial ischemia model...
  13. Cho M, Song W, Paick J. Suppression of Cavernosal Fibrosis in a Rat Model. Sex Med Rev. 2018;6:572-582 pubmed publisher
    ..involving angiotensin-II- and TGF-β1-driven Smad and non-Smad pathways, TGF-β1-Wnt10b, and histone deacetylase (HDAC)-TGF-β1 pathways, positive therapeutic results were obtained with PDE5Is, TGF-β1 antagonists, HDAC inhibitors, ..
  14. Laknaur A, Foster T, Bobb L, Ramesh A, Ladson G, Hood D, et al. Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene. J Appl Toxicol. 2016;36:827-35 pubmed publisher
    ..blot analysis revealed that BaP exposure caused decreases in class I HDACs 1 and 3 and increases in class II HDAC 5, cyclo-oxygenase-2 and nuclear translocation of NFκB-p65 relative to controls...
  15. Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp D, et al. Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension. Free Radic Biol Med. 2016;99:167-178 pubmed publisher
    ..The goal of this study was to determine whether inhibition of histone deacetylases (HDAC) affects the expression of Nox isoforms and reduces pulmonary hypertension...
  16. Zhang Q, Yang F, Li X, Zhang H, Chu X, Zhang H, et al. Trichostatin A protects against intestinal injury in rats with acute liver failure. J Surg Res. 2016;205:1-10 pubmed publisher
    Histone deacetylase (HDAC) inhibitors have been widely applied in the clinic as anticancer drugs against multiple neoplasms and proved their anti-inflammation under different pathology recently...
  17. Zapletal O, Tylichová Z, Neca J, Kohoutek J, Machala M, Milcova A, et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. Arch Toxicol. 2017;91:2135-2150 pubmed publisher
    ..In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic ..
  18. Zhang H, Shao Z, Alibin C, Acosta C, Anderson H. Liganded peroxisome proliferator-activated receptors (PPARs) preserve nuclear histone deacetylase 5 levels in endothelin-treated Sprague-Dawley rat cardiac myocytes. PLoS ONE. 2014;9:e115258 pubmed publisher
    ..from the nucleus, a key event during hypertrophy, since crosstalk occurs between PPARs and other members of the HDAC family...
  19. Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, et al. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014;289:34743-67 pubmed publisher
    ..Treatment with histone deacetylase (HDAC) inhibitor sodium butyrate (NaBu) induced PKCδ expression in cultured neurons, brain slices, and animal models...
  20. D Amato L, Dell aversana C, Conte M, Ciotta A, Scisciola L, Carissimo A, et al. ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias. Epigenetics. 2015;10:6-18 pubmed publisher
    ..The finding that GEF protein modulation by HDAC inhibition impacts on cell differentiation may be important for understanding the antitumor mechanism(s) by which ..
  21. Stefanowicz D, Lee J, Lee K, Shaheen F, Koo H, Booth S, et al. Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects. Respir Res. 2015;16:95 pubmed publisher
    ..However, we were unable to modify the expression of these genes with the use of the HDAC inhibitor TSA in healthy subjects...
  22. Bose P, Verstovsek S. Developmental Therapeutics in Myeloproliferative Neoplasms. Clin Lymphoma Myeloma Leuk. 2017;17S:S43-S52 pubmed publisher
    ..individuals, and inhibitors of human double minute 2 (HDM2) have shown promise in preclinical studies, as have HDAC inhibitors such as givinostat (both in the laboratory and in the clinic)...
  23. Liu P, Liu C. Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling. J Biomed Sci. 2016;23:90 pubmed
    Histone deacetylase (HDAC) activities modify chromatin structure and play a role in learning and memory during developmental processes...
  24. Chidambaram A, Kavya S, Chidambaram R, Subbiah R, Jayaraj J, Muthusamy K, et al. Design, synthesis and characterization of ?, ?-unsaturated carboxylic acid and its urea based derivatives that explores novel epigenetic modulators in human non-small cell lung cancer A549 cell line. J Cell Physiol. 2017;: pubmed publisher
    ..These inhibitors directed against HDAC enzymes have become an important therapeutic tool in oncology; consequently, scientific efforts have fortified the ..
  25. Li L, Lee C, Lin C, Chen N, Chuang L, Hung C, et al. Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. PLoS ONE. 2017;12:e0172571 pubmed publisher
    ..We hypothesized that trichostatin A (TSA), a HDAC inhibitor, can reduce MV-augmented bleomycin-induced EMT by inhibiting the HDAC4 and Akt pathways...
  26. Zhang H, Fu J, Fan T, Zhang W, Wang Z, Wang L, et al. Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma. Chin Med. 2015;10:9 pubmed publisher
    ..Moreover, YGW reduced inflammatory cytokines such as IL-4, IL-5, and IL-13 by upregulating the activities of HDAC7 (P = 0.003)/10 (P = 0.003), HDAC11 (P < 0...
  27. Singh A, Bishayee A, Pandey A. Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy. Nutrients. 2018;10: pubmed publisher
    ..modification is controlled by the balance between histone acetyltransferase and (HAT) and histone deacetylase (HDAC) enzymes. Imbalance between the activities of these two enzymes is associated with various forms of cancer...
  28. Vent Schmidt R, Wen R, Zong Z, Chiu C, Tam B, May C, et al. Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic X. laevis Models of Retinitis Pigmentosa. J Neurosci. 2017;37:1039-1054 pubmed publisher
    ..These effects of VPA were paralleled by treatment with three additional histone deacetylase (HDAC) inhibitors, but not other antipsychotics, chemical chaperones, or VPA structural analogues...
  29. Xue K, Gu J, Zhang Q, Mavis C, Hernandez Ilizaliturri F, Czuczman M, et al. Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents. J Cancer Res Clin Oncol. 2016;142:379-87 pubmed publisher
    ..Given their influence in multiple regulatory pathways, HDAC inhibition is an attractive strategy to evaluate its anti-proliferation activity in cancer cells...
  30. Tambo Y, Hosomi Y, Sakai H, Nogami N, Atagi S, Sasaki Y, et al. Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy. Invest New Drugs. 2017;35:217-226 pubmed publisher
    ..Conclusion In Japanese NSCLC patients previously treated with platinum-based chemotherapy, DR therapy did not improve PFS compared with docetaxel alone and increased toxicity. ..
  31. Gamal Eldeen A, Abdel Hameed S, El Daly S, Abo Zeid M, Swellam M. Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. Biomed Pharmacother. 2017;88:689-697 pubmed publisher
    ..Histone deacetylase (HDAC) activity was inhibited by FH, FW, and FHPNT, with/without magnetism. FHP3/magnetism resulted in HDAC inhibition...
  32. Desravines D, Serna Martin I, Schneider R, Mas P, Aleksandrova N, Jensen M, et al. Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7. Sci Rep. 2017;7:3678 pubmed publisher
    ..Here we have studied its interaction with HDAC7, a class IIa deacetylase that interacts with the corepressor complex together with the highly active class I ..
  33. Chen Y, Yeh F, Yeh S, Ma H, Hung S, Hung M, et al. Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2. J Biol Chem. 2011;286:10671-80 pubmed publisher
    ..After validating the targets, we found that myocyte enhancer factor-2 interacting transcriptional repressor (MITR)/HDAC9c was expressed in osteoblasts and greatly decreased in adipocytes...
  34. Kim H, Kim S, Ahn S. Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability. Oncol Rep. 2016;35:235-42 pubmed publisher
    ..b>HDAC inhibitors have been considered as a potential therapeutic approach for various types of cancers...
  35. Zhou L, Chen S, Zhang Y, Kmieciak M, Leng Y, Li L, et al. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. Blood. 2016;127:2219-30 pubmed publisher
    Two classes of novel agents, NEDD8-activating enzyme (NAE) and histone deacetylase (HDAC) inhibitors, have shown single-agent activity in acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS)...
  36. Gong C, Gao A, Zhang Y, Su M, Chen F, Sheng L, et al. Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy. Eur J Med Chem. 2016;112:81-90 pubmed publisher
    ..We have previously developed a series of bisthiazole-based hydroxamic acids as novel potent HDAC inhibitors...
  37. Morales C, Li D, Pedrozo Z, May H, Jiang N, Kyrychenko V, et al. Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. Sci Signal. 2016;9:ra34 pubmed publisher
    ..In neonatal rat cardiomyocytes, loss of TSC2 abolished HDAC-dependent inhibition of mTOR activity, and increased expression of TSC2 was sufficient to reduce hypertrophy in ..
  38. Chen C, Hou X, Wang G, Pan W, Yang X, Zhang Y, et al. Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors. Eur J Med Chem. 2017;133:11-23 pubmed publisher
    Inhibition of histone deacetylase (HDAC) has been regarded as a potential therapeutic approach for treatment of multiple diseases including cancer...
  39. Lee J, Ko J, Yi J. Histone deacetylase inhibitor (HDACi) upregulates activin A and activates the Smad signaling pathway in melanomas. J Dermatol Sci. 2018;90:13-20 pubmed publisher
    Histone deacetylase (HDAC) is an enzyme that regulates gene expression, cell cycle arrest, apoptosis and modulation of various pathways...
  40. Azghandi S, Prell C, van der Laan S, Schneider M, Malik R, Berer K, et al. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. 2015;46:197-202 pubmed publisher
    Recent genome-wide association studies identified the histone deacetylase 9 (HDAC9) gene region as a major risk locus for large-vessel stroke and coronary artery disease...
  41. Chen P, Huang C, Meng X, Li J. Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis. Biochimie. 2015;116:61-9 pubmed publisher
    ..years, the role of HDACs in liver fibrosis initiation and progression, as well as the therapeutic effects of HDAC inhibitors, has been well studied...
  42. Khan D, Gonzalez C, Tailor N, Hamedani M, Leygue E, Davie J. Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing. J Cell Physiol. 2016;231:2196-204 pubmed publisher
    ..In colon carcinoma HCT 116 cells, HDAC inhibition specifically increased KAT2B occupancy as well as H3 and H4 acetylation of the H3K4 trimethylated (..
  43. Chung M, Park J, Asgar J, Ro J. Transcriptome analysis of trigeminal ganglia following masseter muscle inflammation in rats. Mol Pain. 2016;12: pubmed
    ..g., Piezo2, Tmem100, and Hdac9)...
  44. Raji I, Yadudu F, Janeira E, Fathi S, Szymczak L, Kornacki J, et al. Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase. Bioorg Med Chem. 2017;25:1202-1218 pubmed publisher
    We herein disclose a series of compounds with potent inhibitory activities towards histone deacetylases (HDAC) and cyclooxygenases (COX)...
  45. Lai J, Leman L, Ku S, Vickers C, Olsen C, Montero A, et al. Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells. Bioorg Med Chem Lett. 2017;27:3289-3293 pubmed publisher
    ..Our study identifies new potential HDACi therapeutics for SMA screened using a disease-relevant SMA neuronal cellular model. ..
  46. Booth L, Roberts J, Poklepovic A, Dent P. [pemetrexed + sildenafil], via autophagy-dependent HDAC downregulation, enhances the immunotherapy response of NSCLC cells. Cancer Biol Ther. 2017;18:705-714 pubmed publisher
  47. Mekala J, Naushad S, Ponnusamy L, Arivazhagan G, Sakthiprasad V, Pal Bhadra M. Epigenetic regulation of miR-200 as the potential strategy for the therapy against triple-negative breast cancer. Gene. 2018;641:248-258 pubmed publisher
    ..In this report, we focus the effect of HDAC inhibitors on TNBC cell proliferation, regulation of microRNA gene expression by a series of HDAC genes, chromatin ..
  48. Di Costanzo A, Del Gaudio N, Conte L, Dell aversana C, Vermeulen M, De The H, et al. The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia. Oncogene. 2018;37:2559-2572 pubmed publisher
    ..Here we show that the HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia...
  49. Beharry A, Judge A. Differential expression of HDAC and HAT genes in atrophying skeletal muscle. Muscle Nerve. 2015;52:1098-101 pubmed publisher
    ..The mRNA levels of Hdac2, Hdac4, Hdac6, Sirt1, p300, Cbp, and Pcaf increased, and Hdac7 decreased in skeletal muscle in each experimental model of muscle atrophy...
  50. Li X, Shi B, Yang Q, Wu J, Wu H, Wang Y, et al. Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer. BMC Cancer. 2015;15:954 pubmed publisher
    ..ChIP assay was performed to show histones level. Cell lines were treated with DNA methyltransferase inhibitor AZA, HDAC inhibitor TSA, or siRNA oligonucleotides to test regulation of CDH1 splicing...
  51. Padmanabhan B, Ramu M, Mathur S, Unni S, Thiyagarajan S. Identification of New Inhibitors for Human SIRT1: An in-silico Approach. Med Chem. 2016;12:347-61 pubmed
    Human SIRT1 is a class III histone deacetylase (HDAC) family protein. As the overexpression of hSIRT1 leads to cancer, inhibiting its HDAC function may be a better strategy for the treatment of cancer...
  52. Poddar S, Kesharwani D, Datta M. Histone deacetylase inhibition regulates miR-449a levels in skeletal muscle cells. Epigenetics. 2016;11:579-87 pubmed publisher
    ..We show that histone deacetylase (HDAC) protein levels and activity are upregulated in the skeletal muscle of diabetic mice...
  53. Chen J, Zhou J, Wu J, Zhang G, Kang L, Ben J, et al. Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract. Curr Eye Res. 2017;42:402-410 pubmed publisher
    ..DNA methyltransferase (DNMT) and histone deacetylase (HDAC) activities were also assayed by enzyme-linked immunosorbent assay (ELISA)-like reaction...
  54. Wen J, Bao Y, Niu Q, Liu J, Yang J, Wang W, et al. Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. Bioorg Med Chem Lett. 2016;26:4372-6 pubmed publisher
    ..Among all the synthesized compounds, 5d and 5e showed better HDAC inhibition than psammaplin A and comparable cytotoxicity against four cancer cell lines (PC-3, MCF-7, A549 and HL-..
  55. Wu J, Xiang S, Zhang M, Fang B, Huang H, Kwon O, et al. Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem. 2018;293:1976-1993 pubmed publisher
    Histone deacetylase 6 (HDAC6), a class IIb HDAC, plays an important role in many biological and pathological processes...
  56. Wang S, Zhu L, Zuo W, Zeng Z, Huang L, Lin F, et al. MicroRNA-mediated epigenetic targeting of Survivin significantly enhances the antitumor activity of paclitaxel against non-small cell lung cancer. Oncotarget. 2016;7:37693-37713 pubmed publisher
    ..basis resulting in Survivin overexpression in NSCLC and investigated the antitumor activity of the class I HDAC inhibitor entinostat in combination with paclitaxel...
  57. Kitadate A, Ikeda S, Abe F, Takahashi N, Shimizu N, Matsue K, et al. Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas. Haematologica. 2018;103:126-135 pubmed publisher
    ..Moreover, these results have potential implications for optimal therapeutic sequences in various CCR4-positive T-cell lymphomas. ..
  58. Wang J, Zhang W, Zou H, Lin Y, Lin K, Zhou Z, et al. 10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K-AKT pathway. Int Immunopharmacol. 2015;28:97-104 pubmed publisher
    ..Cell proliferation, HDAC activity and histone acetylation level of FLS cells treated with 10H2DA were detected by MTT assay, Colorimetric ..
  59. Kim G, Jung H, Kim J, Lee Y. Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor. PLoS ONE. 2015;10:e0132680 pubmed publisher
    ..In this regard, the specific interaction between the HDAC domain of class IIa HDACs and the C-terminal region of SMRT repression domain 3 (SRD3c) is known to be critical, ..
  60. Pinto G, Shtaif B, Phillip M, Gat Yablonski G. Growth attenuation is associated with histone deacetylase 10-induced autophagy in the liver. J Nutr Biochem. 2016;27:171-80 pubmed publisher
    Our previous data suggested that the histone deacetylase (HDAC) SIRT1 is involved in mediating the effect of nutrition on growth...
  61. Booiman T, Loukachov V, van Dort K, van t Wout A, Kootstra N. DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner. PLoS ONE. 2015;10:e0144229 pubmed publisher
    ..of DYRK1A resulted in reactivation of latent HIV-1 provirus to a similar extent as two commonly used broad-spectrum HDAC inhibitors...
  62. Okada K, Hakata S, Terashima J, Gamou T, Habano W, Ozawa S. Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells. Oncol Rep. 2016;36:1875-85 pubmed publisher
    Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects...
  63. Schroeder F, Gilbert T, Feng N, Taillon B, Volkow N, Innis R, et al. Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. ACS Chem Neurosci. 2017;8:662-668 pubmed publisher
    ..Our objective was to investigate HDAC expression in a large postmortem sample set representing healthy and disease brains...
  64. Lino Cardenas C, Kessinger C, Cheng Y, MacDonald C, Macgillivray T, Ghoshhajra B, et al. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun. 2018;9:1009 pubmed publisher
    ..signaling and VSMC cytoskeleton both lead to the formation of a ternary complex comprising the histone deacetylase HDAC9, the chromatin-remodeling enzyme BRG1, and the long noncoding RNA MALAT1...
  65. Zuckermann A, La Ragione R, Baines D, Williams R. Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. Br J Pharmacol. 2015;172:5306-17 pubmed publisher
    ..by several VPA-related compounds with known PPARγ agonist activity, independent of histone deacetylase (HDAC) inhibitory activity...
  66. Edderkaoui M, Xu S, Chheda C, Morvaridi S, Hu R, Grippo P, et al. HDAC3 mediates smoking-induced pancreatic cancer. Oncotarget. 2016;7:7747-60 pubmed publisher
    ..The pro-cancer effects of smoking were prevented by Histone Deacetylase HDAC I/II inhibitor Saha...
  67. Butchbach M, Lumpkin C, Harris A, Saieva L, Edwards J, Workman E, et al. Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy. Exp Neurol. 2016;279:13-26 pubmed publisher
    ..on SMN expression in the spinal cords of treated SMNΔ7 SMA mice; however, they inhibited histone deacetylase (HDAC) activity and restored the normal phosphorylation states of Akt and glycogen synthase kinase 3β, both of which are ..
  68. Galán M, Varona S, Orriols M, Rodríguez J, Aguiló S, Dilmé J, et al. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech. 2016;9:541-52 pubmed publisher
    ..Inhibition of histone deacetylase (HDAC) activity could be a promising therapeutic option in cardiovascular diseases...
  69. Zwick V, Simões Pires C, Cuendet M. Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitors. J Enzyme Inhib Med Chem. 2016;31:209-214 pubmed
    Histone deacetylases (HDAC) are involved in several diseases including cancer, cardiovascular and neurodegenerative disorders, and the search for inhibitors is a current topic in drug discovery...
  70. Choi S, Braun T, Henig I, Gatza E, Magenau J, Parkin B, et al. Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT. Blood. 2017;130:1760-1767 pubmed publisher
    The oral histone deacetylase (HDAC) inhibitor (vorinostat) is safe and results in low incidence of acute graft-versus-host disease (GVHD) after reduced-intensity conditioning, related donor hematopoietic cell transplantation (HCT)...
  71. Wang J, Zhao L, Wei Z, Zhang X, Wang Y, Li F, et al. Inhibition of histone deacetylase reduces lipopolysaccharide-induced-inflammation in primary mammary epithelial cells by regulating ROS-NF-кB signaling pathways. Int Immunopharmacol. 2018;56:230-234 pubmed publisher
    Histone deacetylase 6 (HDAC6) is the sole member of the HDAC family, that is predominantly located in the cytoplasm and has substrate specificity for nonhistone proteins, such as α-Tubulin...
  72. Wu L, Wang J, Conidi A, Zhao C, Wang H, Ford Z, et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016;19:1060-72 pubmed publisher
    ..is a critical intrinsic timer that controls the onset of SC differentiation by recruiting histone deacetylases HDAC 1 and 2 (HDAC1/2) and nucleosome remodeling and deacetylase complex (NuRD) co-repressor complexes in mice...
  73. Dhoke N, Kalabathula E, Kaushik K, Geesala R, Sravani B, Das A. Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. Stem Cell Res. 2016;17:170-80 pubmed publisher
    ..Trichostatin A (TSA)-mediated HDAC inhibition led to an increased level of AcH3 and AcH4 along with cyclins B1 and D2...
  74. Wang X, Han Y, Sabina S, Cui N, Zhang S, Liu Z, et al. HDAC9 Variant Rs2107595 Modifies Susceptibility to Coronary Artery Disease and the Severity of Coronary Atherosclerosis in a Chinese Han Population. PLoS ONE. 2016;11:e0160449 pubmed publisher
    A previous genome-wide association study showed that a single nucleotide polymorphism (SNP) rs2107595 in histone deacetylase 9 (HDAC9) gene was associated with large artery stroke (LAS) in Caucasians...
  75. Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Kimura H, Miwa S, et al. Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models. Anticancer Res. 2016;36:4477-82 pubmed
    ..Valproic acid has histone deacetylase (HDAC) inhibitory activity...
  76. Nagaraja S, Vitanza N, Woo P, Taylor K, Liu F, Zhang L, et al. Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017;31:635-652.e6 pubmed publisher
    ..Targeting oncogenic transcription through either of these methods synergizes with HDAC inhibition, and DIPG cells resistant to HDAC inhibitor therapy retain sensitivity to CDK7 blockade...
  77. Benn C, Butler R, Mariner L, Nixon J, Moffitt H, Mielcarek M, et al. Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PLoS ONE. 2009;4:e5747 pubmed publisher
    ..b>HDAC7 is of interest in this context because SAHA has been shown to decrease HDAC7 expression in cell culture systems in ..
  78. Fischle W, Dequiedt F, Fillion M, Hendzel M, Voelter W, Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001;276:35826-35 pubmed
    ..Here we describe the identification and functional characterization of HDAC7, a new member of the human class II HDAC family...
  79. Savickiene J, Treigyte G, Magnusson K, Navakauskiene R. Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors. Ann N Y Acad Sci. 2009;1171:321-33 pubmed publisher
    ..Partial differentiation to granulocytes was induced by 3 micromol/L RA, and its combination with HDAC inhibitors did not enhance RA-induced but potentiated apoptosis...
  80. Ye Y, Kirkham McCarthy L, Lahue R. The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination. DNA Repair (Amst). 2016;43:1-8 pubmed publisher
    ..Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions...
  81. Chen J, Sahakian E, Powers J, Lienlaf M, Perez Villarroel P, Knox T, et al. Functional Analysis of Histone Deacetylase 11 (HDAC11). Methods Mol Biol. 2016;1436:147-65 pubmed publisher
    The physiological role of histone deacetylase 11 (HDAC11), the newest member of the HDAC family, remained largely unknown until the discovery of its regulatory function in immune cells...
  82. Yang C, Liu Z, Dong D, Schacht J, ARYA D, Sha S. Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci. 2017;11:315 pubmed publisher
    ..In this study, we investigated three FDA-approved histone deacetylase (HDAC) inhibitors (vorinostat/SAHA, belinostat, and panobinostat) as protectants against aminoglycoside-induced ..
  83. Jamiruddin M, Kaitsuka T, Hakim F, Fujimura A, Wei F, Saitoh H, et al. HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies. Biochem Biophys Res Commun. 2016;481:25-30 pubmed publisher
    ..We focused on this family, and found that HDAC9 was up-regulated in ALT-positive cells...
  84. Arhoma A, Chantry A, Haywood Small S, Cross N. SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture. Exp Cell Res. 2017;360:226-235 pubmed publisher
    ..In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D ..
  85. Yamada T, Amann J, Tanimoto A, Taniguchi H, Shukuya T, Timmers C, et al. Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations. Mol Cancer Ther. 2018;17:17-25 pubmed publisher
    ..proteins BIM and FASL and cell-cycle regulators p21Cip1 and p27Kip1 We now show that an HDAC inhibitor affects the expression and localization of FOXO proteins and wanted to determine whether the combination ..
  86. Vancurova I, Uddin M, Zou Y, Vancura A. Combination Therapies Targeting HDAC and IKK in Solid Tumors. Trends Pharmacol Sci. 2018;39:295-306 pubmed publisher
    The rationale for developing histone deacetylase (HDAC) inhibitors (HDACi) as anticancer agents was based on their ability to induce apoptosis and cell cycle arrest in cancer cells...
  87. Chen J, Wu D, Li T, Yang K, Cheng L, Zhou Z, et al. Arylurea Derivatives: A Class of Potential Cancer Targeting Agents. Curr Top Med Chem. 2017;17:3099-3130 pubmed publisher
    ..MMPs), LIM kinase (Limk), Nicotinamide Phosphoribosyltransferase (Nampt), and Histone Deacetylase (HDAC); (6) arylureas from the rational modification of natural products...
  88. Yanda M, Liu Q, Cebotaru V, Guggino W, Cebotaru L. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem. 2017;292:17897-17908 pubmed publisher
    ..Intracellular Ca2+ was higher in PC1-knock-out cells than in control cells. HDAC inhibition caused a drop in intracellular Ca2+ and increased ATP-simulated Ca2+ release...
  89. Zheng L, Kelly C, Battista K, Schaefer R, Lanis J, Alexeev E, et al. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol. 2017;199:2976-2984 pubmed publisher
    ..IEC barrier formation, induced IL-10RA mRNA, IL-10RA protein, and transactivation through activated Stat3 and HDAC inhibition...
  90. Lindberg M, Popko Scibor A, Hansson M, Wallberg A. SUMO modification regulates the transcriptional activity of MAML1. FASEB J. 2010;24:2396-404 pubmed publisher
    ..Furthermore, SUMOylation enhances MAML1 interaction with HDAC7, which decreases MAML1 transcriptional activity...
  91. Adams C, Hiebert S, Eischen C. Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer Res. 2016;76:736-48 pubmed publisher
    Alterations in the expression or function of histone deacetylases (HDAC) contribute to the development and progression of hematologic malignancies...
  92. Huong T, Dung D, Huan N, Cuong L, Hai P, Huong L, et al. Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. Bioorg Chem. 2017;71:160-169 pubmed publisher
    ..that these novel and simple N-hydroxybenzamides are potential for further development as anticancer agents and further investigation of similarly simple N-hydroxybenzamides should be warranted to obtain more potent HDAC inhibitors.