Gene Symbol: HDAC7
Description: histone deacetylase 7
Alias: HD7, HD7A, HDAC7A, histone deacetylase 7, histone deacetylase 7A
Species: human
Products:     HDAC7

Top Publications

  1. Mottet D, Bellahcene A, Pirotte S, Waltregny D, Deroanne C, Lamour V, et al. Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circ Res. 2007;101:1237-46 pubmed
    ..Using small interfering RNAs, we observed that HDAC7 silencing in endothelial cells altered their morphology, their migration, and their capacity to form capillary ..
  2. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  3. Parra M, Kasler H, McKinsey T, Olson E, Verdin E. Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem. 2005;280:13762-70 pubmed
    b>HDAC7, a class II histone deacetylase that is highly expressed in thymocytes, inhibits both transcription of the orphan steroid nuclear receptor Nur77 and induction of apoptosis in response to activation of the T-cell receptor (TCR)...
  4. Xiao H, Chung J, Kao H, Yang Y. Tip60 is a co-repressor for STAT3. J Biol Chem. 2003;278:11197-204 pubmed
    ..We also show that Tip60 associates with histone deacetylase 7 (HDAC7) through its N-terminal zinc finger-containing region and that HDAC7 activity is required for the ..
  5. Dequiedt F, Van Lint J, Lecomte E, Van Duppen V, Seufferlein T, Vandenheede J, et al. Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J Exp Med. 2005;201:793-804 pubmed
    ..Recently, we showed that the class IIa member, HDAC7, regulates negative selection by repressing expression of Nur77, an orphan nuclear receptor involved in antigen-..
  6. Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier B, et al. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 2003;18:687-98 pubmed
    We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes...
  7. Kato H, Tamamizu Kato S, Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004;279:41966-74 pubmed
    ..assay revealed that regions containing amino acids 735-785 of HIF-1alpha and amino acids 669-952 of HDAC7 were minimum contact sites of the interaction...
  8. Ishola A, Adewole K. Phytosterols and triterpenes from Morinda lucida Benth. exhibit binding tendency against class I HDAC and HDAC7 isoforms. Mol Biol Rep. 2019;46:2307-2325 pubmed publisher
  9. Witt A, Lee C, Lee T, Azzam D, Wang B, Caslini C, et al. Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene. 2017;36:1707-1720 pubmed publisher
    ..Utilizing a novel CSC model, we discovered that the HDACs, HDAC1 and HDAC7, are specifically over-expressed in CSCs when compared to non-stem-tumour-cells (nsTCs)...

More Information

Publications130 found, 100 shown here

  1. Butler P, Staruschenko A, Snyder P. Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. J Biol Chem. 2015;290:12497-503 pubmed publisher
    ..Moreover, TSA increased ENaC current in Fischer rat thyroid and kidney collecting duct epithelia. We found that HDAC7 is expressed in the kidney collecting duct, supporting a potential role for this histone deacetylase in ENaC ..
  2. Stemig M, Astelford K, Emery A, Cho J, Allen B, Huang T, et al. Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF. PLoS ONE. 2015;10:e0123843 pubmed publisher
    ..We recently reported that histone deacetylase 7 (HDAC7) binds to and represses the transcriptional activity of MITF in osteoclasts, and that loss of HDAC7 ..
  3. Chen J, Wang N, Dong M, Guo M, Zhao Y, Zhuo Z, et al. The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection. Diabetes. 2015;64:4088-98 pubmed publisher
    Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis...
  4. Yu X, Wang M, Wu J, Han Q, Zhang X. ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway. J Exp Clin Cancer Res. 2019;38:40 pubmed publisher
    ..immunoprecipitation and dual-luciferase assays were performed to demonstrate that histone deacetylase enzyme-7 (HDAC7) is the target gene of ZNF326...
  5. Zelin E, Freeman B. Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1. J Mol Biol. 2015;427:1644-54 pubmed publisher
    ..We find that DNA binding by HSF1 is controlled by lysine deacetylases with HDAC7, HDAC9, and SIRT1 distinctly increasing the magnitude and length of a heat shock response (HSR)...
  6. Azagra A, Román González L, Collazo O, Rodriguez Ubreva J, de Yebenes V, Barneda Zahonero B, et al. In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development. J Exp Med. 2016;213:2591-2601 pubmed
    ..A prominent example is HDAC7, a class IIa HDAC that shows a lymphoid-specific expression pattern within the hematopoietic system...
  7. Zhang Y, Zhu D, Wei Y, Wu Y, Cui W, Liuqin L, et al. A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. Acta Biomater. 2019;86:223-234 pubmed publisher
    ..In this study, we hypothesized that the extracellular matrix (ECM)-derived collagen I hydrogel loaded with histone deacetylase 7 (HDAC7)-derived-phosphorylated 7-amino-acid peptide (7Ap) could restrain LV remodeling and improve cardiac ..
  8. Zhang Q, Han X, Chen J, Xie X, Xu J, Zhao Y, et al. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) mediate cell density-dependent proinflammatory responses. J Biol Chem. 2018;293:18071-18085 pubmed publisher
    ..motif (TAZ) are localized to the nucleus, bind to TEA domain transcription factors (TEADs), recruit histone deacetylase 7 (HDAC7) to the promoter region of COX-2, and repress its transcription at low cell density and that high ..
  9. Uba A, Yelekçi K. Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6. Comput Biol Chem. 2018;77:318-330 pubmed publisher
    ..00). Their binding affinity against HDAC6 compared to class I HDACs (1, 2, 3 & 8) and a class IIa member (HDAC7), was calculated by molecular docking using AutoDock4...
  10. Zhang D, Hu X, Li J, Hoogstra Berends F, Zhuang Q, Esteban M, et al. Converse role of class I and class IIa HDACs in the progression of atrial fibrillation. J Mol Cell Cardiol. 2018;125:39-49 pubmed publisher
    ..Conversely, overexpression of class IIa HDACs (HDAC4, HDAC5, HDAC7 or HDAC9) did not affect CaT in controls, with HDAC5 and HDAC7 overexpression even protecting against tachypacing-..
  11. Lodewick J, Sampaio C, Boxus M, Rinaldi A, Coulonval K, Willems L, et al. Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology. 2013;10:75 pubmed publisher
    ..The identification of the acetyltransferase p300 and the deacetylase HDAC7 as enzymes modulating Tax acetylation points to new therapeutic targets for the treatment of HTLV-1 infected ..
  12. Bradley E, Carpio L, Olson E, Westendorf J. Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification. J Biol Chem. 2015;290:118-26 pubmed publisher
    ..We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation...
  13. Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, et al. Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis. Oncogene. 2019;38:1410-1431 pubmed publisher
    ..Here we identify that AGO2 can be acetylated by P300/CBP and deacetylated by HDAC7, and that acetylation occurs at three sites K720, K493, and K355...
  14. Romero A, Del Río E, Vilanova E, Sogorb M. RNA transcripts for the quantification of differentiation allow marked improvements in the performance of embryonic stem cell test (EST). Toxicol Lett. 2015;238:60-9 pubmed publisher
    ..Nrcam, Nes, Shh and Pnpla6), endoderm formation (Flk1 and Afp), mesoderm formation (Mesp1, Vegfa, Myo1e and Hdac7) and general cellular processes (Cdk1, Myc, Jun, Mixl, Cer and Wnt3)...
  15. Pagan J, Arnold J, Hanchard K, Kumar R, Bruno T, Jones M, et al. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem. 2007;282:15248-57 pubmed
    ..Specifically, BCoR-L1 coprecipitates with the Class II HDACs, HDAC4, HDAC5, and HDAC7, suggesting that they are involved in its role as a transcriptional repressor...
  16. Ai W, Zheng H, Yang X, Liu Y, Wang T. Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity. Nucleic Acids Res. 2007;35:6137-49 pubmed
    ..In addition, Tip60 and HDAC7, previously shown to interact with each other and repress transcription, inhibited HDC promoter activity in a dose-..
  17. Shakespear M, Hohenhaus D, Kelly G, Kamal N, Gupta P, Labzin L, et al. Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages. J Biol Chem. 2013;288:25362-74 pubmed publisher
    ..Here we investigated HDAC-dependent inflammatory responses in mouse macrophages. Of the classical Hdacs, Hdac7 was expressed at elevated levels in inflammatory macrophages (thioglycollate-elicited peritoneal macrophages) as ..
  18. Jang S, Chen H, Gregersen P, Diamond B, Kim S. Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele. JCI Insight. 2017;2:e89569 pubmed publisher
    ..In addition, KLF4 directly recruits histone deacetylases (HDAC4, HDAC6, and HDAC7), established negative regulators of gene expression...
  19. Choi S, Kee H, Jin L, Ryu Y, Sun S, Kim G, et al. Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat. Biomed Pharmacother. 2018;101:145-154 pubmed publisher
    ..Piceatannol inhibited only HDAC7 activity...
  20. Liu M, Chen B, Pei L, Zhang Q, Zou Y, Xiao H, et al. Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. Toxicology. 2018;408:1-10 pubmed publisher
    ..The expression levels of glucocorticoid receptor (GR) and histone deacetylase 7 (HDAC7) were increased in fetal testes...
  21. Batu E, Kosukcu C, Taşkıran E, Sahin S, Akman S, Sozeri B, et al. Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus. J Rheumatol. 2018;: pubmed publisher
    ..Further, in 1 patient, we determined a strong candidate variant in HDAC7 (histone decetylase 7). Five patients had homozygous alterations in genes coding early complement proteins...
  22. Oh J, Lee C, Oh S, Jeon S, Choi J, Hwang S, et al. Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ. 2016;23:1804-1814 pubmed publisher
    ..Twist2 partially retains histone deacetylase 7 (HDAC7) in the nucleus and recruits it to the Nur77 promoter region to repress Nur77 in positively ..
  23. Bryant H, Farrell P. Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency. J Virol. 2002;76:10290-8 pubmed
  24. Lomonte P, Thomas J, Texier P, Caron C, Khochbin S, Epstein A. Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. J Virol. 2004;78:6744-57 pubmed
    ..We discuss the putative consequences of such an interaction for the biology of the virus both during lytic infection and reactivation from latency. ..
  25. Desravines D, Serna Martin I, Schneider R, Mas P, Aleksandrova N, Jensen M, et al. Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7. Sci Rep. 2017;7:3678 pubmed publisher
    ..Here we have studied its interaction with HDAC7, a class IIa deacetylase that interacts with the corepressor complex together with the highly active class I ..
  26. Chen C, Preston J, Zhou S, Fuller H, Morgan D, Chen R. Proteomic analysis of age-related changes in ovine cerebrospinal fluid. Exp Gerontol. 2018;108:181-188 pubmed publisher
    ..17 of them decreased >25% but <50%, and histone deacetylase 7 (HDAC7) was gradually decreased for over 80%...
  27. Daneshpajooh M, Eliasson L, Bacos K, Ling C. MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. Acta Diabetol. 2018;55:1231-1235 pubmed publisher
    ..For example, we have showed that the expression of histone deacetylase 7 (HDAC7) is increased in pancreatic islets of individuals with T2D and that increased levels of Hdac7 in β-..
  28. Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, et al. PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science. 2010;330:1104-7 pubmed publisher
    ..1-related transcription factor, and Hdac7, a histone deacetylase gene. PiggyBac and Sleeping Beauty have different integration preferences...
  29. Ouaïssi M, Silvy F, Loncle C, Ferraz da Silva D, Martins Abreu C, Martinez E, et al. Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. PLoS ONE. 2014;9:e108520 pubmed publisher
    ..Moreover, we have evaluated by using an in vitro model system of human pancreatic tumor cell line whether HDAC7 knockdown may affect the cell behavior...
  30. Uba A, Yelekçi K. Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies. Comput Biol Chem. 2018;75:131-142 pubmed publisher
    ..top 20 compounds with reasonable binding modes were evaluated for selectivity by further docking against HDAC6 and HDAC7 using Autodock4...
  31. Jing X, Sui W, Wang S, Xu X, Yuan R, Chen X, et al. HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation. J Neurosci. 2017;37:3848-3863 pubmed publisher
    ..b>SIGNIFICANCE STATEMENT The current findings demonstrated the effects of histone deacetylase 7 (HDAC7) on hippocampal-dependent memories...
  32. Navarro M, Goebel J, Feijoo Carnero C, Morrice N, Cantrell D. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol. 2011;12:352-61 pubmed publisher
    ..A focus on chromatin regulators showed that CTLs had high expression of the histone deacetylase HDAC7 but continually phosphorylated and exported this transcriptional repressor from the nucleus...
  33. Navarro M, Goebel J, Hukelmann J, Cantrell D. Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks. Mol Cell Proteomics. 2014;13:3544-57 pubmed publisher
    ..In other cell types, PKD substrates include class II histone deacetylases such as HDAC7 and actin regulatory proteins such as Slingshot...
  34. Barneda Zahonero B, Collazo O, Azagra A, Fernández Duran I, Serra Musach J, Islam A, et al. The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma. Cell Death Dis. 2015;6:e1635 pubmed publisher
    ..Here we report that histone deacetylase 7 (HDAC7) is underexpressed in pro-B acute lymphoblastic leukemia (pro-B-ALL) and Burkitt lymphoma...
  35. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. HDAC7 modulates TNF-α-mediated suppression of Leydig cell steroidogenesis. Mol Cell Biochem. 2015;406:83-90 pubmed publisher
    ..In the present study, we demonstrate that TNF-α activates histone deacetylases 7 (HDAC7), which regulates the expression of steroidogenic enzyme genes in Leydig cells...
  36. Lee C, Chawla A, Urbiztondo N, Liao D, Boisvert W, Evans R, et al. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003;302:453-7 pubmed
    ..PPARdelta and its ligands may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis. ..
  37. Beharry A, Judge A. Differential expression of HDAC and HAT genes in atrophying skeletal muscle. Muscle Nerve. 2015;52:1098-101 pubmed publisher
    ..The mRNA levels of Hdac2, Hdac4, Hdac6, Sirt1, p300, Cbp, and Pcaf increased, and Hdac7 decreased in skeletal muscle in each experimental model of muscle atrophy...
  38. Kaletsch A, Pinkerneil M, Hoffmann M, Jaguva Vasudevan A, Wang C, Hansen F, et al. Effects of novel HDAC inhibitors on urothelial carcinoma cells. Clin Epigenetics. 2018;10:100 pubmed publisher
    ..In most cell lines, 19i as well as SAHA induced HDAC5 and HDAC4 mRNAs while rather repressing HDAC7. UC cell lines overexpressing HDAC4 were not significantly less sensitive to 19i...
  39. Scott F, Fuchs G, Boyd S, Denault J, Hawkins C, Dequiedt F, et al. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem. 2008;283:19499-510 pubmed publisher
    ..putative caspase-8 substrates using the Prediction of Protease Specificity (PoPS) program, one of which is histone deacetylase 7 (HDAC7). HDAC7 is cleaved faster than any other caspase-8 substrate described to date...
  40. Ha C, Jhun B, Kao H, Jin Z. VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. Arterioscler Thromb Vasc Biol. 2008;28:1782-8 pubmed publisher
    ..In particular, histone deacetylases 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity...
  41. Gao C, Ho C, Reineke E, Lam M, Cheng X, Stanya K, et al. Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Mol Cell Biol. 2008;28:5658-67 pubmed publisher
    ..Here, we show that histone deacetylase 7 (HDAC7) knockdown reduces the size and the number of the PML NBs in human umbilical vein endothelial cells ..
  42. Korfei M, Skwarna S, Henneke I, MacKenzie B, Klymenko O, Saito S, et al. Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis. Thorax. 2015;70:1022-32 pubmed publisher
    ..expression of genes associated with ECM synthesis, proliferation and cell survival, as well as in suppression of HDAC7, and was paralleled by induction of endoplasmic reticulum stress and apoptosis...
  43. Johnston H, Carter M, Larrayoz M, Clarke J, Garbis S, Oscier D, et al. Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation. Mol Cell Proteomics. 2018;17:776-791 pubmed publisher
    ..Several other proteins (e.g. Wee1, HMOX1/2, HDAC7 and INPP5F) were identified with significant overexpression that also represent potential targets...
  44. Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, et al. ?-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology. 2012;142:572-81 pubmed publisher
    ..These findings indicate the involvement of a posttranslational mechanism in disruption of PML-NB organization in cancer cells and provide more information about the oncogenic functions of ?-catenin. ..
  45. Xie X, Song X, Yuan S, Cai H, Chen Y, Chang X, et al. Histone acetylation regulates orphan nuclear receptor NR4A1 expression in hypercholesterolaemia. Clin Sci (Lond). 2015;129:1151-61 pubmed publisher
    ..Supporting our clinical observations, cholesterol enhanced p300 acetyltransferase and decreased HDAC7 (histone deacetylase 7) recruitment to the NR4A1 promoter region, resulting in histone H3 hyperacetylation and further ..
  46. Wang Y, Yang Y, Luo Y, Yin Y, Wang Q, Li Y, et al. Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis. Clin Immunol. 2013;149:46-54 pubmed publisher
    ..Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and, SUV39H2 were significantly down-regulated in SSc B cells relative to controls...
  47. Gerçeker E, Boyacıoglu S, Kasap E, Baykan A, Yuceyar H, Yıldırım H, et al. Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. Oncol Rep. 2015;34:1905-14 pubmed publisher
    ..addition, there was a significantly higher overexpression of HDAC1 and PAK1 genes in the UC group, and of HDAC1, HDAC7, PAK1 and AURKB genes in the CRC group...
  48. Zhang H, Fu J, Fan T, Zhang W, Wang Z, Wang L, et al. Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma. Chin Med. 2015;10:9 pubmed publisher
    ..Moreover, YGW reduced inflammatory cytokines such as IL-4, IL-5, and IL-13 by upregulating the activities of HDAC7 (P = 0.003)/10 (P = 0.003), HDAC11 (P < 0...
  49. Clocchiatti A, Di Giorgio E, Viviani G, Streuli C, Sgorbissa A, Picco R, et al. The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro. J Cell Sci. 2015;128:3961-76 pubmed publisher
    ..Upregulation of the transcription of MEF2 proteins is coupled to downregulation of HDAC7, which occurs independently from changes in mRNA levels, and proteasome- or autophagy-mediated degradation...
  50. Dequiedt F, Martin M, von Blume J, Vertommen D, Lecomte E, Mari N, et al. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol. 2006;26:7086-102 pubmed
    ..Using HDAC7 as a paradigm, we extend these findings by demonstrating that signal-independent phosphorylation of the most N-..
  51. Hutt D, Herman D, Rodrigues A, Noel S, Pilewski J, Matteson J, et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol. 2010;6:25-33 pubmed publisher
    ..Biological silencing of all known class I and II HDACs reveals that HDAC7 plays a central role in restoration of DeltaF508 function...
  52. Trujillo Gonzalez I, Cervantes Roldán R, Gonzalez Noriega A, Michalak C, Reyes Carmona S, Barrios Garcia T, et al. Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7. Mol Genet Metab. 2014;111:321-330 pubmed publisher
    ..in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7. We show further that HCS interaction with HDACs and its function in transcriptional repression is not affected by ..
  53. Jensen E, Schroeder T, Bailey J, Gopalakrishnan R, Westendorf J. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res. 2008;23:361-72 pubmed
    b>HDAC7 associates with Runx2 and represses Runx2 transcriptional activity in a deacetylase-independent manner. HDAC7 suppression accelerates osteoblast maturation...
  54. Lee H, Chun M, Kandror K. Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. J Biol Chem. 2001;276:16597-600 pubmed
    ..Here we report that the histone acetyltransferase Tip60 and the histone deacetylase HDAC7 interact with one of the ET receptors, ETA, as determined by yeast two-hybrid analysis, glutathione S-transferase ..
  55. Zhu C, Chen Q, Xie Z, Ai J, Tong L, Ding J, et al. The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. J Mol Med (Berl). 2011;89:279-89 pubmed publisher
    ..Herein, we report that HDAC7 is a crucial player in cancer cell proliferation...
  56. Kasap E, Gerçeker E, Boyacıoglu S, Yuceyar H, Yıldırm H, Ayhan S, et al. The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. Tumour Biol. 2016;37:3071-80 pubmed publisher
    ..PAK1, NEK6, AURKA, AURKB, HDAC1, and HDAC7 were significantly more overexpressed in CRC subjects compared to the controls (p < 0.05)...
  57. Kong N, Davis M, Chai L, Winoto A, Tjian R. MEF2C and EBF1 Co-regulate B Cell-Specific Transcription. PLoS Genet. 2016;12:e1005845 pubmed publisher
    ..This is further supported by interaction between MEF2C and the histone deacetylase, HDAC7, revealing a likely mechanism to repress the myeloid transcription program...
  58. Liu H, Wang Q, Zhang Y, Qi D, Li M, Guo W, et al. Pioglitazone up-regulates long non-coding RNA MEG3 to protect endothelial progenitor cells via increasing HDAC7 expression in metabolic syndrome. Biomed Pharmacother. 2016;78:101-109 pubmed publisher
    ..The luciferase reporter assay and RIP assay showed that MEG3 targeted miR-140-5p. In addition, the HDAC7 expression levels were regulated by miR-140-5p and MEG3...
  59. Mohseni J, Al Najjar B, Wahab H, Zabidi Hussin Z, Sasongko T. Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients. J Hum Genet. 2016;61:823-30 pubmed publisher
    ..In silico methods analyzed the intermolecular interactions between each compound and HDAC2/HDAC7. SMN2 mRNA transcript levels and SMN protein levels showed notable increases in both cell types, except for ..
  60. Ouaissi M, Sielezneff I, Silvestre R, Sastre B, Bernard J, Lafontaine J, et al. High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas. Ann Surg Oncol. 2008;15:2318-28 pubmed publisher
    ..Remarkably, 9 of the 11 PA (approximately 81%) showed significant increase of HDAC7 mRNA levels. In contrast to PA samples, message for HDAC7 was reduced in CP, SC, and IMPN specimens...
  61. Benn C, Butler R, Mariner L, Nixon J, Moffitt H, Mielcarek M, et al. Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PLoS ONE. 2009;4:e5747 pubmed publisher
    ..b>HDAC7 is of interest in this context because SAHA has been shown to decrease HDAC7 expression in cell culture systems in ..
  62. Urbich C, Rossig L, Kaluza D, Potente M, Boeckel J, Knau A, et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood. 2009;113:5669-79 pubmed publisher
    ..The derepression of angiogenic genes by HDAC5 inactivation may provide a useful therapeutic target for induction of angiogenesis. ..
  63. Yu D, Chen W, Ren J, Zhang T, Yang K, Wu G, et al. VEGF-PKD1-HDAC7 signaling promotes endothelial progenitor cell migration and tube formation. Microvasc Res. 2014;91:66-72 pubmed publisher
    ..In particular, histone deacetylase 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity...
  64. Zhao X, Hsu K, Lim J, Bruggeman L, Kao H. α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J Biol Chem. 2015;290:338-49 pubmed publisher
    ..Taken together, our data identify ACTN4 as a novel coactivator for NF-κB transcription factors in podocytes. Importantly, this nuclear function of ACTN4 is independent of its actin binding activity in the cytoplasm. ..
  65. Kim H, Ramirez C, Su Z, Kong A. Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells. J Nutr Biochem. 2016;33:54-62 pubmed publisher
    ..DNMT1 and DNMT3a and the histone deacetylases (HDACs) HDAC1, HDAC2, HDAC3 and HDAC8 (Class I) and HDAC6 and HDAC7 (Class II), and HDAC activity...
  66. Dudakovic A, Gluscevic M, Paradise C, Dudakovic H, Khani F, Thaler R, et al. Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing. Gene. 2017;609:28-37 pubmed publisher
    ..g., HDAC5 and HDAC7)...
  67. Li W, Su Z, Guo Y, Zhang C, Wu R, Gao L, et al. Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells. Chem Res Toxicol. 2017;: pubmed publisher
    ..F10 also downregulated the protein level of DNMT1, DNMT3a, DNMT3b, HDAC1, HDAC4, and HDAC7 and the activity of DNMTs and HDACs...
  68. Sun G, Yu R, Evans R, Shi Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007;104:15282-7 pubmed
    ..Taken together, these findings demonstrate a mechanism for neural stem cell proliferation through transcriptional repression of p21 and pten gene expression by TLX-HDAC interactions. ..
  69. Murata H, Yoshimoto K, Hatae R, Akagi Y, Mizoguchi M, Hata N, et al. Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression. J Neurooncol. 2015;125:33-41 pubmed publisher
    ..with malignant transformation, tumor recurrence, tumor heterogeneity, chromatin-modifying gene expression, and HDAC7 expression. The MES score positively correlated with tumor grade, whereas the PN score did not...
  70. Myers D, Lau T, Markegard E, Lim H, Kasler H, Zhu M, et al. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017;19:1558-1571 pubmed publisher
    ..Here, we demonstrate that tonic signals through LAT constitutively export the repressor HDAC7 from the nucleus of CD4+ T cells...
  71. Gao C, Li X, Lam M, Liu Y, Chakraborty S, Kao H. CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. FEBS Lett. 2006;580:5096-104 pubmed
    CRM1, 14-3-3 proteins, and CaMK play important roles in trafficking of HDAC7, but the interplay between these proteins in this process is not clearly understood...
  72. Chakraborty S, Reineke E, Lam M, Li X, Liu Y, Gao C, et al. Alpha-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7. J Biol Chem. 2006;281:35070-80 pubmed
    b>Histone deacetylase 7 (HDAC7) is a member of class IIa HDACs that regulate myocyte enhancer factor-2 (MEF2)-mediated transcription and participate in multiple cellular processes such as T cell apoptosis...
  73. Li L, Yang X. Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4). Methods Mol Biol. 2016;1436:31-45 pubmed publisher
    ..these enzymes are divided into four classes, with class II further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, HDAC9) and IIb (HDAC6 and HDAC10)...
  74. Kao H, Downes M, Ordentlich P, Evans R. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000;14:55-66 pubmed
    ..SMRT-interacting proteins resulted in the isolation of the recently described HDAC5 and a new family member termed HDAC7. Molecular and biochemical results indicate that this interaction is direct and in vivo evidence colocalizes SMRT, ..
  75. Turtoi A, Mottet D, Matheus N, Dumont B, Peixoto P, Hennequière V, et al. The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. 2012;15:543-54 pubmed publisher
    ..Previous studies have shown that specific inhibition of HDAC7 blocks angiogenesis both in vitro and in vivo...
  76. Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, et al. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res. 2010;106:1202-11 pubmed publisher
    ..This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism...
  77. Yu Y, Cao F, Yu X, Zhou P, Di Q, Lei J, et al. The expression of HDAC7 in cancerous gastric tissues is positively associated with distant metastasis and poor patient prognosis. Clin Transl Oncol. 2017;19:1045-1054 pubmed publisher
    ..The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, ..
  78. Marks P, Richon V, Rifkind R. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst. 2000;92:1210-6 pubmed
    ..The hydroxamic acid-based HPCs are potentially effective agents for cancer therapy and, possibly, cancer chemoprevention. ..
  79. Su Y, Gao C, Liu Y, Guo S, Wang A, Wang B, et al. Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013;33:1546-60 pubmed publisher
    ..We have identified the filamin B (FLNB) as a novel HDAC7-interacting protein that is required for temporal and spatial regulation of vascular endothelial growth factor (..
  80. Fischle W, Dequiedt F, Fillion M, Hendzel M, Voelter W, Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001;276:35826-35 pubmed
    ..Here we describe the identification and functional characterization of HDAC7, a new member of the human class II HDAC family...
  81. Lemercier C, Brocard M, Puvion Dutilleul F, Kao H, Albagli O, Khochbin S. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem. 2002;277:22045-52 pubmed
    ..Our results indicate that three related class II deacetylases, HDAC4, HDAC5, and HDAC7 can associate with BCL6 in vivo and in vitro...
  82. Barneda Zahonero B, Román González L, Collazo O, Rafati H, Islam A, Bussmann L, et al. HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages. PLoS Genet. 2013;9:e1003503 pubmed publisher
    ..We report that the histone deacetylase HDAC7 was highly expressed in pre-B cells but dramatically down-regulated during cellular lineage conversion to ..
  83. Ahn M, Yoon J. Histone deacetylase 7 silencing induces apoptosis and autophagy in salivary mucoepidermoid carcinoma cells. J Oral Pathol Med. 2017;46:276-283 pubmed publisher
    ..We found that HDAC7 expression was selectively reduced by HDAC inhibitor apicidin in salivary mucoepidermoid carcinoma (MEC) cells...
  84. Bakin R, Jung M. Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis. J Biol Chem. 2004;279:51218-25 pubmed
    ..Here we describe the novel discovery that the nuclear encoded Class II human histone deacetylase HDAC7 localizes to the mitochondrial inner membrane space of prostate epithelial cells and exhibits cytoplasmic ..
  85. Compagnucci C, Barresi S, Petrini S, Bertini E, Zanni G. Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1. Biochem Biophys Res Commun. 2015;459:179-183 pubmed publisher
    ..We found that inhibition of the ROCK pathway in induced pluripotent stem cells, leads to nuclear export of HDAC7 and transcriptional activation of the orphan nuclear receptor NR4A1 while in cells with constitutive ROCK ..
  86. Ficner R. Novel structural insights into class I and II histone deacetylases. Curr Top Med Chem. 2009;9:235-40 pubmed
    ..Here recent developments in the crystal structure analysis of human HDAC4, HDAC7, and HDAC8, which all belong to the family of zinc ion-dependent HDACs, are described...
  87. Liang J, Lei T, Song Y, Yanes N, Qi Y, Fu M. RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling. J Biol Chem. 2009;284:29383-90 pubmed publisher
    ..Taken together, these data suggest that TTP may also function in vivo as a modulator in suppressing the transcriptional activity of NF-kappaB. ..
  88. Wang S, Li X, Parra M, Verdin E, Bassel Duby R, Olson E. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A. 2008;105:7738-43 pubmed publisher
    ..We show that VEGF induces the phosphorylation of three conserved serine residues in histone deacetylase 7 (HDAC7) via protein kinase D, which promotes nuclear export of HDAC7 and activation of VEGF-responsive ..
  89. To M, Yamamura S, Akashi K, Charron C, Haruki K, Barnes P, et al. Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7. Chest. 2012;141:1233-1242 pubmed publisher
    ..PBMCs were exposed to hypoxia (1% oxygen, 5% CO(2), and 94% N(2)) for 24 h, and HIF-1? and HDAC7 protein expression in nuclear extracts were determined by sodium dodecyl sulfate poly acrylamide gel ..
  90. Yang J, Margariti A, Zeng L. Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell Differentiation Toward Smooth Muscle Lineage. Methods Mol Biol. 2016;1436:95-108 pubmed publisher
    ..In this chapter, we describe a strategy to detect HDAC7 alternative splicing and analyze its function on ES cell differentiation.
  91. Shen J, Wu S, Guo W, Liang S, Li X, Yang X. Epigenetic regulation of pro-inflammatory cytokine genes in lipopolysaccharide -stimulated peripheral blood mononuclear cells from broilers. Immunobiology. 2017;222:308-315 pubmed publisher
    ..The expression of pro-inflammatory cytokines related with the expression of HDAC7 and HDAC10 which can influence histone acetylation, and may also be affected by increasing the acetylation of non-..
  92. Ho R, Chan J, Fan H, Kioh D, Lee B, Chan E. In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases. Biochemistry. 2017;56:4871-4878 pubmed publisher
    ..We investigated the structure-inhibition relationships of SCFAs with class I HDAC3 and class IIa HDAC7 using in silico docking simulation and the in vitro human recombinant HDAC inhibition assay...