HDAC4

Summary

Gene Symbol: HDAC4
Description: histone deacetylase 4
Alias: AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase A
Species: human

Top Publications

  1. pmc Interaction of ruminal bacteria in the production and utilization of maltooligosaccharides from starch
    M A Cotta
    Fermentation Biochemistry Unit, USDA Agricultural Research Service, Peoria, Illinois 61604
    Appl Environ Microbiol 58:48-54. 1992
  2. ncbi Effect of sugars and malate on ruminal microorganisms
    S A Martin
    Department of Animal and Dairy Science, The University of Georgia, Athens 30602 2771, USA
    J Dairy Sci 83:2574-9. 2000
  3. ncbi Caspase-mediated specific cleavage of human histone deacetylase 4
    Fang Liu
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, John Morgan 180H, Philadelphia, PA 19104, USA
    J Biol Chem 279:34537-46. 2004
  4. pmc Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea
    Fu Quan Chen
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, USA
    J Neurochem 108:1226-36. 2009
  5. ncbi Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    Wolfgang Fischle
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Mol Cell 9:45-57. 2002
  6. pmc The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
    M G Guenther
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:6091-101. 2001
  7. pmc Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell Biol 20:6904-12. 2000
  8. pmc Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4
    Johannes Backs
    Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 28:3437-45. 2008
  9. pmc Three proteins define a class of human histone deacetylases related to yeast Hda1p
    C M Grozinger
    Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:4868-73. 1999
  10. pmc Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 25:57-70. 2007

Detail Information

Publications172 found, 100 shown here

  1. pmc Interaction of ruminal bacteria in the production and utilization of maltooligosaccharides from starch
    M A Cotta
    Fermentation Biochemistry Unit, USDA Agricultural Research Service, Peoria, Illinois 61604
    Appl Environ Microbiol 58:48-54. 1992
    ..Selenomonas ruminantium HD4 grew poorly on starch, digested only a small portion of the available substrate, and generated no detectable ..
  2. ncbi Effect of sugars and malate on ruminal microorganisms
    S A Martin
    Department of Animal and Dairy Science, The University of Georgia, Athens 30602 2771, USA
    J Dairy Sci 83:2574-9. 2000
    ..When S. ruminantium strains HD4 and H18 were incubated in basal medium that contained DL-lactate, some DL-lactate was utilized by both strains ..
  3. ncbi Caspase-mediated specific cleavage of human histone deacetylase 4
    Fang Liu
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, John Morgan 180H, Philadelphia, PA 19104, USA
    J Biol Chem 279:34537-46. 2004
    Histone deacetylase 4 (HDAC4) is a class II HDAC implicated in controlling gene expression important for diverse cellular functions, but little is known about how its expression and stability are regulated...
  4. pmc Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea
    Fu Quan Chen
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, USA
    J Neurochem 108:1226-36. 2009
    ..Protein levels of HDAC1, HDAC3 and HDAC4 were increased while the histone acetyltransferases such as CREB-binding protein and p300 remained unchanged...
  5. ncbi Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    Wolfgang Fischle
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Mol Cell 9:45-57. 2002
    ..Here, we show that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/SMRT...
  6. pmc The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
    M G Guenther
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:6091-101. 2001
    ..In contrast, SMRT does not activate the class II HDAC4, with which it also interacts...
  7. pmc Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell Biol 20:6904-12. 2000
    ..Here we describe results demonstrating that HDAC4, a member of class II human HDACs, is localized in the cytoplasm and/or the nucleus...
  8. pmc Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4
    Johannes Backs
    Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 28:3437-45. 2008
    Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates histone deacetylase 4 (HDAC4), a class IIa HDAC, resulting in the cytosolic accumulation of HDAC4 and the derepression of the transcription factor myocyte enhancer ..
  9. pmc Three proteins define a class of human histone deacetylases related to yeast Hda1p
    C M Grozinger
    Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:4868-73. 1999
    ..The corresponding full-length cDNAs were cloned and defined as HDAC4, HDAC5, and HDAC6...
  10. pmc Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 25:57-70. 2007
    ..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis...
  11. ncbi Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
    ..MEF2 proteins also interact with the class II histone deacetylases HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes...
  12. ncbi CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction
    Ji Ho Suh
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 22:33-46. 2008
    ..Taken together, these results suggest that CRIF1 acts as an AR corepressor and may play an important role in the regulation of AR-positive growth of prostate cancer...
  13. pmc HDAC4 deacetylase associates with and represses the MEF2 transcription factor
    E A Miska
    Wellcome CRC Institute, Department of Pathology, Cambridge, UK
    EMBO J 18:5099-107. 1999
    ..Here we identify and characterize HDAC4, a representative of a new human histone deacetylase family, which is homologous to the yeast HDA1 deacetylase...
  14. ncbi Class II histone deacetylases: versatile regulators
    Eric Verdin
    Gladstone Institute of Virology and Immunology, University of California San Francisco, PO Box 419100, San Francisco, CA 94141, USA
    Trends Genet 19:286-93. 2003
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated...
  15. ncbi Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4
    H D Youn
    Center for Cancer Research, Department of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:22563-7. 2000
    ..with several distinct repressors including Cabin1(cain), MEF2-interacting transcriptional repressor (MITR), and HDAC4. It has been previously shown that Cabin1 is associated with MEF2 in a calcium-sensitive manner; activated ..
  16. ncbi A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p
    W Fischle
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 274:11713-20. 1999
    ..In immunoprecipitation experiments, HDAC-A interacted specifically with several cellular proteins, indicating that it might be part of a larger multiprotein complex...
  17. pmc CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    Johannes Backs
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 116:1853-64. 2006
    ..Here we show that calcium/calmodulin-dependent kinase II (CaMKII) signals specifically to HDAC4 by binding to a unique docking site that is absent in other class IIa HDACs...
  18. pmc Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
    E Y Huang
    Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Genes Dev 14:45-54. 2000
    ..that one RD, which is conserved in N-CoR and SMRT, represses transcription by interacting directly with class II HDAC4 and HDAC5. Endogenous N-CoR and SMRT each associate with HDAC4 in a complex that does not contain mSin3A or HDAC1...
  19. pmc HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 19:7816-27. 1999
    ..Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity to the deacetylase ..
  20. ncbi The histone deacetylase 9 gene encodes multiple protein isoforms
    Kevin Petrie
    Leukemia Research Fund Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    J Biol Chem 278:16059-72. 2003
    ..HDAC9 is expressed in a tissue-specific pattern that partially overlaps that of HDAC4. Within the human hematopoietic system, expression of HDAC9 is biased toward cells of monocytic and lymphoid ..
  21. pmc Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 97:14400-5. 2000
    ..To further define the mechanisms that confer CaMK responsiveness to HDAC4 and -5, we performed yeast two-hybrid screens to identify HDAC-interacting factors...
  22. pmc The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
    Olivier Kirsh
    Unite de Recombinaison et Expression Genetique, INSERM U 163, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    EMBO J 21:2682-91. 2002
    ..Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier...
  23. pmc Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
    C M Grozinger
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 97:7835-40. 2000
    ..To characterize the cellular function of the recently identified HDAC4 and HDAC5 proteins, complexes were isolated by immunoprecipitation...
  24. pmc Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications
    Xuan Zhao
    Department of Pharmacology and Cancer Biology, P O Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 25:8456-64. 2005
    The class II deacetylase histone deacetylase 4 (HDAC4) negatively regulates the transcription factor MEF2. HDAC4 is believed to repress MEF2 transcriptional activity by binding to MEF2 and catalyzing local histone deacetylation...
  25. ncbi Novel structural insights into class I and II histone deacetylases
    Ralf Ficner
    Department of Molecular Structural Biology, Institute for Microbiology and Genetics, GZMB, Georg August University Gottingen, 37077 Gottingen, Germany
    Curr Top Med Chem 9:235-40. 2009
    ..Here recent developments in the crystal structure analysis of human HDAC4, HDAC7, and HDAC8, which all belong to the family of zinc ion-dependent HDACs, are described...
  26. pmc PP2A regulates HDAC4 nuclear import
    Gabriela Paroni
    Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Biologia and MATI Center of Excellence, Universita di Udine, 33100 Udine, Italy
    Mol Biol Cell 19:655-67. 2008
    ..Here we show that HDAC4 forms a complex with the PP2A holoenzyme C alpha, A alpha, B/PR55 alpha...
  27. ncbi Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity
    Jonathan K L Chan
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Biol Chem 278:23515-21. 2003
    ..The amino terminus of HDAC4 can associate with the DNA-bound MEF2 in vitro, suggesting that it does not repress MEF2 simply by disrupting the ..
  28. ncbi Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
    Yun Hye Jin
    Department of Biochemistry and Urology, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju 361 763, South Korea
    J Biol Chem 279:29409-17. 2004
    ..Our findings demonstrate that the level of RUNX3 protein is controlled by the competitive acetylation and deacetylation of the three lysine residues, revealing a new mechanism for the posttranslational regulation of RUNX3 expression...
  29. pmc Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
    Gary D Kao
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Biol 160:1017-27. 2003
    ..b>HDAC4 foci gradually disappeared in repair-proficient cells but persisted in repair-deficient cell lines or cells ..
  30. doi A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Cell 133:978-93. 2008
    ..Both Cys-274/Cys-276 in DnaJb5 and Cys-667/Cys-669 in HDAC4 are oxidized and form intramolecular disulfide bonds in response to reactive oxygen species (ROS)-generating ..
  31. ncbi The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking
    X Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:35042-8. 2001
    In C2C12 myoblasts, endogenous histone deacetylase HDAC4 shuttles between cytoplasmic and nuclear compartments, supporting the hypothesis that its subcellular localization is dynamically regulated...
  32. pmc Xylose uptake by the ruminal bacterium Selenomonas ruminantium
    D K Williams
    Department of Microbiology, University of Georgia, Athens 30602
    Appl Environ Microbiol 56:1683-8. 1990
    Selenomonas ruminantium HD4 does not use the phosphoenolpyruvate phosphotransferase system to transport xylose (S. A. Martin and J. B. Russell, J. Gen. Microbiol. 134:819-827, 1988). Xylose uptake by whole cells of S...
  33. ncbi Anticancer effects of the MHY218 novel hydroxamic acid-derived histone deacetylase inhibitor in human ovarian cancer cells
    Heui Sook Jeon
    College of Pharmacy, Pusan National University, Jangjeon Dong, Geumjeong Gu, Busan 609 735, South Korea
    Int J Oncol 37:419-28. 2010
    ..MHY218 significantly reduced the expression of HDAC4 and HDAC7 in SKOV-3 cells...
  34. pmc HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
    S E Rundlett
    Department of Biological Chemistry, University of California School of Medicine, Los Angeles 90095, USA
    Proc Natl Acad Sci U S A 93:14503-8. 1996
    ..These data demonstrate that histone acetylation state has a role in regulating both heterochromatic silencing and regulated gene expression...
  35. ncbi Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha
    David Z Qian
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 66:8814-21. 2006
    ..Coimmunoprecipitation studies showed that class II HDAC4 and HDAC6 were associated with HIF-1 alpha protein...
  36. pmc Fermentation of xylans by Butyrivibrio fibrisolvens and other ruminal bacteria
    R B Hespell
    Department of Animal Sciences, University of Illinois, Urbana 61801
    Appl Environ Microbiol 53:2849-53. 1987
    ..of carbohydrate that supported low levels of growth of nonxylanolytic strains such as Selenomonas ruminantium HD4. Compared to growth on hexoses, the same array of fermentation acids was produced upon growth on xylans for most ..
  37. ncbi Growth and fermentation responses of Selenomonas ruminantium to limiting and non-limiting concentrations of ammonium chloride
    S C Ricke
    Department of Poultry Science, Texas A and M University, College Station 77843 2472, USA
    Appl Microbiol Biotechnol 46:169-75. 1996
    ..of this study was to assess fermentation product, growth rate and growth yield responses of Selenomonas ruminantium HD4 to limiting and non-limiting ammonia concentrations. The ammonia half-inhibition constant for S...
  38. ncbi The development of quality assurance programs for radiotherapy within the German Hodgkin Study Group (GHSG). Introduction, continuing work, and results of the radiotherapy reference panel
    Rolf Peter Muller
    Department of Radiation Oncology, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Strahlenther Onkol 181:557-66. 2005
    ..Extensive continuing quality assurance programs (QAPs) during the study generations have been performed. The purpose of the present article is to summarize the experiences and results of the performed and ongoing QAPs...
  39. doi Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Oxford Road, Manchester, M1 5GD, UK
    Biol Rev Camb Philos Soc 84:637-52. 2009
    ..transcription in the nucleus through the phosphorylation, deactivation and translocation of histone deacetylase 4 (HDAC4) from the nucleus to the cytoplasm...
  40. ncbi Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system
    Ernesto Bockamp
    Institute of Toxicology Mouse Genetics, Johannes Gutenberg University, D 55131 Mainz, Germany
    J Gene Med 9:308-18. 2007
    ..Moreover, the tightness of tetracycline-regulated gene switches can be substantially improved by complementing transcriptional activators with antagonizing repressors...
  41. pmc A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression
    Huibin Tang
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 20:1120-31. 2009
    ..Recently, it was reported that histone deacetylase 4 (HDAC4) can mediate denervation-induced myogenin and nicotinic acetylcholine receptor gene expression...
  42. doi Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells
    Bruno Cadot
    Department of Oncology, IRBM Merck Research Laboratories, Rome, Italy
    Cancer Res 69:6074-82. 2009
    We investigated the role of histone deacetylase 4 (HDAC4) using RNA interference (RNAi) and knockout cells to specifically address its role in cell cycle progression in tumor and normal cells...
  43. ncbi Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors
    A Newman-Tancredi
    Psychopharmacology Department, Institut de Recherches Servier, Croissy sur Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 359:447-53. 1999
    ..The present study determined its affinity and agonist efficacy at recombinant human (h) dopamine hD2, hD3 and hD4 and serotonin (5-HT) h5-HT1A, h5-HT1B and h5-HT1D receptors...
  44. doi Kinetics of repression by modified p53 on the PDGF beta-receptor promoter
    Weiwen Yang
    Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Int J Cancer 123:2020-30. 2008
    ..As binding of p53 to the promoter increased, previously bound p73, DeltaNp73, c-Myc, HDAC1 and HDAC4 were dismissed from the repressed promoter, and p300 was recruited...
  45. ncbi The capability of reprogramming the male chromatin after fertilization is dependent on the quality of oocyte maturation
    Luisa Gioia
    Dipartimento di Scienze Biomediche Comparate, Fisiologia Veterinaria, Università di Teramo, Piazza Aldo Moro 45, Teramo 64100, Italy
    Reproduction 130:29-39. 2005
    ..Collectively, these data demonstrated that some pig IVM oocytes fail to acquire full remodelling competence which is independent from their ooplasmic ability to morphologically reorganize the sperm nucleus into PN...
  46. doi Homology modeling and atomic level binding study of Leishmania MAPK with inhibitors
    Mahendra Awale
    National Institute of Pharmaceutical Education and Research, Nagar, Punjab, India
    J Mol Model 16:475-88. 2010
    ..kinases ERK1 and ERK2, which are components of the Ras-MAPK signal transduction pathway which is complexed with HDAC4 protein, and their inhibition is of significant therapeutic interest in cancer biology...
  47. ncbi Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays
    Mitchell Stark
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 67:2632-42. 2007
    ..HDs were also common for PTPRD (n = 7) and HDAC4 (n = 3), TSGs recently found to be mutated or deleted in other cancer types...
  48. pmc HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity
    Mahesh P Gupta
    Department of Surgery, Committee on Molecular Medicine, Biological Science Division, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 283:10135-46. 2008
    ..We found that a Class II HDAC, HDAC4, and an HAT, PCAF, associate with cardiac myofilaments...
  49. ncbi The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists
    Thomas A Pugsley
    CNS Pharmacology and Chemistry, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:219-26. 2002
    ..2-chloro-4-[4-[(1H-benzimidazol-2-yl)methyl]-1-piperzinyl]) that displaced [3H]spiperone binding to hD4.2 with an affinity (Ki) of 3.7 nM. PD 89211 exhibited high selectivity for the DA D4...
  50. doi High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas
    Mehdi Ouaissi
    Service de Chirurgie Digestive et Oncologique, Pôle d Oncologie et Spécialité Médico Chirurgicales, Assistance Pubique Hôpitaux de Marseille, Hopital Timone, 264 rue Saint Pierre, Marseille 13000, France
    Ann Surg Oncol 15:2318-28. 2008
    ..The aim of the present study was to evaluate the expression levels of members of class I (HDAC1, 2,, 3), class II (HDAC4, 5, 6, and 7), and class III (SIRT1, 2, 3, 4, 5, and 6) in a set of surgically resected pancreatic tissues.
  51. pmc An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
    Nicolas Stankovic-Valentin
    CNRS UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59017 Lille Cedex, France
    Mol Cell Biol 27:2661-75. 2007
    ..that HIC1 transcriptional repression activity is positively controlled by two types of deacetylases, SIRT1 and HDAC4, which increase the deacetylation and SUMOylation, respectively, of K314...
  52. ncbi [35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine
    Christoph Czermak
    Department of General Psychiatry I, Sigmund Freud Clinics Graz, Wagner Jauregg Platz 1, 8053 Graz, Austria
    Eur J Pharmacol 531:20-4. 2006
    ..study was to investigate possible differences between the human dopamine D4 receptor 48 bp polymorphism variants hD4.2, hD.4. and hD4...
  53. ncbi Proposal of Quinella ovalis gen. nov., sp. nov., based on phylogenetic analysis
    L R Krumholz
    Department of Animal Sciences, Univeristy of Illinois, Urbana
    Int J Syst Bacteriol 43:293-6. 1993
    ..ruminantium GA192 (ATCC 12561; type strain) and S. ruminantium subsp. lactilytica HD4 (ATCC 27209) was done. These sequences were compared with those of other bacteria...
  54. ncbi Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate
    Chun Ting Wang
    Department of Medical Intensive Care Unit, Shandong Province Hospital, Affiliated Hospital of Shandong University, Jinan, Shandong 250021, China
    Chin Med J (Engl) 121:1707-11. 2008
    ..Cell cycle was detected by flow cytometry. Expression of acetylating histone H4 and of histones deacetylase 4 (HDAC4) were determined by Western blot...
  55. pmc Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway
    Elena Kozhemyakina
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Mol Cell Biol 29:5751-62. 2009
    ..PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear ..
  56. doi 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors
    Ester Muraglia
    IRBM Merck Research Laboratories Rome, Via Pontina Km 30, 600 Pomezia, 00040 Rome, Italy
    Bioorg Med Chem Lett 18:6083-7. 2008
    ..led to the discovery that 2-trifluoroacetylthiophene 1,3,4-oxadiazole derivatives are very potent low nanomolar HDAC4 inhibitors, highly selective over class I HDACs (HDAC 1 and 3), and moderately stable in HCT116 cell culture.
  57. ncbi Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells
    Adrian Newman-Tancredi
    Division of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France
    Int J Neuropsychopharmacol 11:293-307. 2008
    ..Here, we report the in-vitro profile of over 30 ligands at recombinant hD4.4 receptors. In [35S]GTPgammaS binding experiments using membranes of CHO-hD4...
  58. pmc High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
    John Evankovich
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 285:39888-97. 2010
    ..We identified the isoforms HDAC1 and HDAC4 as critical in regulating acetylated HMGB1 release...
  59. pmc Exercise-induced histone modifications in human skeletal muscle
    Sean L McGee
    Department of Physiology, the University of Melbourne 3010, Australia
    J Physiol 587:5951-8. 2009
    ..While we found no evidence of proteasomal degradation of the class IIa HDACs, we found that HDAC4 and 5 were exported from the nucleus during exercise, thereby removing their transcriptional repressive function...
  60. pmc Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3
    S Dorland
    Division of Molecular Biology and Genetics, Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Genetics 154:573-86. 2000
    ..Genetic analysis demonstrates that SDS3 functions in the same genetic pathway as SIN3 and RPD3, and coimmunoprecipitation experiments show that Sds3 is physically present in the Sin3 complex...
  61. doi Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola
    Wanessa D Wight
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Mol Plant Microbe Interact 22:1258-67. 2009
    ..Depudecin-minus mutants have a small (10%) but statistically significant reduction in virulence on cabbage (Brassica oleracea) but not on Arabidopsis. The role of depudecin in virulence is, therefore, less dramatic than that of HC toxin...
  62. ncbi Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase
    Byung Chul Jeong
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 18:13-25. 2004
    ..The ARR19 repression of AR transactivation is through the recruitment of histone deacetylase 4 (HDAC4) by ARR19. Overexpression of HDAC4 further inhibits the ARR19-repressed AR transactivation...
  63. pmc Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development
    Indrani Rajan
    Neuroscience Research, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA
    PLoS ONE 4:e6612. 2009
    Histone deacetylase 4 (HDAC4) has been associated with muscle & bone development [1]-[6]. N-terminal MEF2 and RUNX2 binding domains of HDAC4 have been shown to mediate these effects in vitro...
  64. pmc A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 7:237. 2010
    ..Finally, some are involved in integration site selection. We have studied the role of the histone deacetylase HDAC4 in these processes...
  65. ncbi 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor
    M Rowley
    Merck Sharp and Dohme, Neuroscience Research Centre, Harlow, Essex, UK
    J Med Chem 40:2374-85. 1997
    ..3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) receptors...
  66. pmc Factors affecting lactate and malate utilization by Selenomonas ruminantium
    J D Evans
    Department of Animal and Dairy Science, The University of Georgia, Athens 30602 2771, USA
    Appl Environ Microbiol 63:4853-8. 1997
    ..ruminantium. When S. ruminantium HD4 and H18 were grown in batch culture on DL-lactate and DL-malate, both strains coutilized both organic acids for the ..
  67. ncbi New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas
    M E Lleonart
    Department of Pathology, Hospital Vall d Hebron, 08035 Barcelona, Spain
    Oncol Rep 16:603-8. 2006
    ..Recently, five genes: RPS6KA6, HDAC4, KIAA0828, TCP1 and Tip60, which modulate p53-dependent function and avoid senescence were identified in a large-..
  68. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..bone formation is exquisitely sensitive to the balance between MEF2C and the corepressor histone deacetylase 4 (HDAC4), such that bone deficiency of Mef2c mutant mice can be rescued by an Hdac4 mutation, and ectopic ossification in ..
  69. ncbi SUMOylation substrates in neuronal intranuclear inclusion disease
    J Takahashi-Fujigasaki
    Division of Neuropathology, The Jikei University School of Medicine, Tokyo, 105 8461, Japan
    Neuropathol Appl Neurobiol 32:92-100. 2006
    ..SUMO-1) and the SUMOylation substrates promyelocytic leukaemia protein (PML) and histone deacetylase 4 (HDAC4)...
  70. pmc Differential expression of selected histone modifier genes in human solid cancers
    Hilal Ozdag
    Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, Cambridge CB2 2XZ, UK
    BMC Genomics 7:90. 2006
    ..types: histone acetyltransferases (HATs)- EP300, CREBBP, and PCAF; histone deacetylases (HDACs)- HDAC1, HDAC2, HDAC4, HDAC5, HDAC7A, and SIRT1; and histone methyltransferases (HMTs)- SUV39H1and SUV39H2...
  71. ncbi Complete nucleotide sequence of a cryptic plasmid from the ruminal bacterium Selenomonas ruminantium HD4 and identification of two predicted open reading frames
    S F Al-Khaldi
    Department of Animal and Dairy Science, The University of Georgia, Athens, Georgia 30602 2771, USA
    Plasmid 42:45-52. 1999
    A cryptic plasmid (pSR1) isolated from Selenomonas ruminantium HD4 was previously cloned into the HindIII site of pBR322 and a restriction map was constructed using HindIII, ClaI, BamHI, and PvuII (S. A. Martin and R. G. Dean, Appl...
  72. pmc Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB G 609, Newark, NJ 07103, USA
    J Cardiovasc Transl Res 3:304-13. 2010
    ..of CaMKII and NFAT by phenylephrine, accompanied by suppression of Ser 632 phosphorylation and nuclear exit of HDAC4 in cardiac myocytes...
  73. doi Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression
    Zhenfeng Duan
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Orthop Res 28:746-52. 2010
    ..These targets included Met and HDAC4-two genes that were observed to be overexpressed in chordoma...
  74. ncbi Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Oncogene 23:6569-80. 2004
    ..Thus interference with Sp-1 transactivation by MeCP2 may contribute to the transcriptional defect of IGFBP-3 expression in NSCLC cells with methylated promoter...
  75. pmc Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway
    Fei Chu
    Children s Memorial Research Center, Children s Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicargo, IL, USA
    Aging Cell 7:516-25. 2008
    ..Since expression of HDAC4 was consistently enhanced in the TSA-resistant cell lines, we suggest that this enzyme may contribute to their ..
  76. pmc Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement
    Lei Wang
    Pharmacology Research Center and the State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
    Neuropsychopharmacology 35:913-28. 2010
    ..neutralizing the chronic cocaine-induced increase in histone modification by the bilateral overexpression of HDAC4 in the NAc shell reduced drug motivation...
  77. ncbi Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor
    Lilin Wang
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Anticancer Res 28:2009-13. 2008
    ....
  78. ncbi Identification of a broad-specificity xylosidase/arabinosidase important for xylooligosaccharide fermentation by the ruminal anaerobe Selenomonas ruminantium GA192
    T R Whitehead
    Fermentation Biochemistry Research Unit, National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, Peoria, IL 61604, USA
    Curr Microbiol 43:293-8. 2001
    ..xylose through xylotetraose and was able to ferment considerable quantities of larger oligosaccharides, to strain HD4, which used only the simple sugars present in the hydrolysate. The ability of S...
  79. ncbi Histone deacetylase: a target for antiproliferative and antiprotozoal agents
    P T Meinke
    Merck Research Laboratories, Department of Medicinal Chemistry, PO Box 2000, Rahway, NJ 07065 0900
    Curr Med Chem 8:211-35. 2001
    ....
  80. ncbi p27Kip1 localization depends on the tumor suppressor protein tuberin
    Margit Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Hum Mol Genet 16:1541-56. 2007
    ..These findings demonstrate p27 localization during the mammalian cell cycle to be under the control of the tumor suppressor tuberin...
  81. pmc Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability
    Valerie Price
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA
    J Neurosci Res 91:407-15. 2013
    ..from different laboratories using cell culture and in vivo model systems indicates that histone deacetylase-4 (HDAC4) plays an essential role in maintaining neuronal survival...
  82. pmc The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
    Donald R Walkinshaw
    Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:9345-62. 2013
    Histone deacetylases 4 (HDAC4), -5, -7, and -9 form class IIa within the HDAC superfamily and regulate diverse physiological and pathological cellular programs...
  83. doi Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression
    H J Thirkettle
    Uro Oncology Research Group, Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Oncogene 28:3663-70. 2009
    ..Our data suggest one mechanism for cells with altered LYRIC/AEG-1 expression to evade apoptosis and increase cell growth during tumourigenesis through the regulation of PLZF repression...
  84. ncbi [Analysis of photoperiod-sensitivity genes in Minghui63, an restorer line of indica rice(Oryza sativa L.)]
    Lin Guang Luo
    State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China
    Yi Chuan Xue Bao 30:804-10. 2003
    ..using heading time nearly isogenic lines EGO-EG7, ER-LR and two heading date QTL-isogenic lines, NIL (Hd1) and NIL (Hd4), with the genes of Nipponbare but Hd1 (Se-1) and Hd4 (E1) genes from Kasalath, respectively, we performed a ..
  85. ncbi [Epigenetic regulation in depression]
    Koji Otsuki
    Department of Neuropsychiatry, Yamaguchi University Graduate School of Medicine, 1 1 1, Minamikogushi, Ube, 755 8505 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:181-6. 2012
    ..We found a reduced level of HDAC4 recruitment at the GDNF promoter region with antidepressants...
  86. doi Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/ GMMG-HD4 trial
    Pieter Sonneveld
    Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 30:2946-55. 2012
    ..We investigated whether bortezomib during induction and maintenance improves survival in newly diagnosed multiple myeloma (MM)...
  87. pmc NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers
    Yewei Liu
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1503, USA
    Am J Physiol Cell Physiol 303:C334-47. 2012
    Reactive oxygen species (ROS) have been linked to oxidation and nuclear efflux of class IIa histone deacetylase 4 (HDAC4) in cardiac muscle...
  88. pmc Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes
    Kyung Ok Kim
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York 14642, USA
    J Cell Biochem 113:2156-66. 2012
    ..does Ski associate with phospho-Smad2 and 3, but its association with phospho-Smad3 is required for recruitment of HDAC4 and 5...
  89. doi Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock
    Chao Xu
    Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Sci Signal 5:ra39. 2012
    ..A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone deacetylases HDAC4 and HDAC5...
  90. doi Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors
    Theodora E Danciu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Cell Biochem 109:417-24. 2010
    ..Twist1 homodimers significantly reduced its ability to interact with two of its binding partners, Runx2 and HDAC4, indicating that disulfide dimerization in response to H(2)O(2) has functional significance...
  91. pmc Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors
    G R Seabrook
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
    Br J Pharmacol 112:728-34. 1994
    ..4. The mobilisation of intracellular calcium by thyrotropin releasing hormone in hD4-GH4C1 cells was also studied using Fura-2 AM microspectrofluorimetry...
  92. pmc Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3
    Anna Saramaki
    Department of Biosciences, University of Kuopio, FIN 70210 Kuopio, Finland
    J Biol Chem 284:8073-82. 2009
    ..Inhibition of MED1, HDAC4, or LSD1 by siRNA also attenuates ligand-induced chromatin looping...
  93. pmc SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor
    Motohiko Oshima
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    J Biol Chem 284:11017-26. 2009
    ..SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR...
  94. pmc HDAC4 regulates neuronal survival in normal and diseased retinas
    Bo Chen
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 323:256-9. 2009
    Histone deacetylase 4 (HDAC4) shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development...
  95. pmc HDAC4 promotes growth of colon cancer cells via repression of p21
    Andrew J Wilson
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA
    Mol Biol Cell 19:4062-75. 2008
    The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner, and it represses differentiation of specific cell types...
  96. doi Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells
    Shue Fen Luo
    Department of Internal Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Toxicol Appl Pharmacol 237:8-21. 2009
    ..scavenger [N-acetyl-L-cysteine (NAC)] or transfection with siRNAs of MyD88, PKCalpha, Src, p47(phox), p300, and HDAC4. Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/..
  97. pmc MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    Ying jie Guan
    Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University Rhode Island Hospital, 1 Hoppin St, Ste 402, Providence, RI 02903, USA
    FASEB J 25:4457-66. 2011
    ..We identified histone deacetylase 4 (HDAC4), an inhibitor of chondrocyte hypertrophy, as a target of miR-365...
  98. pmc HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway
    Hong P Chen
    Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island 02908, USA
    J Cell Biochem 112:3246-55. 2011
    ..A (TSA,50  nmol/L) and sodium butyrate (NaB, 200  µmol/L) that causes the pronounced reduction of HDAC4 activity, decreased cell death and increased viability of ESCs in response to oxidant stress...
  99. pmc Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor
    Yali Kong
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road, Washington DC 20057, USA
    Mol Cancer Ther 10:1591-9. 2011
    ..Furthermore, immunostaining of inhibitor exposed cells for HDAC4 showed accumulation of this enzyme in the cytoplasmic compartment with concomitant increased acetylation of ..
  100. doi Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer
    Soon Young Park
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 302 718, Republic of Korea
    Oncol Rep 25:1677-81. 2011
    ..We compared the expression of HDAC isoforms between MCF-7 and MDA-MB-231 cells and found greater expression of HDAC4, 6 and 8 in MDA-MB-231 cells by RT-PCR and Western blot analyses...

Research Grants79

  1. Histone deacetylases in pathogenesis of heart failure
    Mahesh Gupta; Fiscal Year: 2007
    ..Recently, we have shown that serum response factor (SRF) is a functional interacting target of HDAC4. In myocytes HDAC4 binds to SRF leading to nuclear localization of the SRF-HDAC4 complex and repression of ..
  2. HDAC4 Viability: Unique Mechanisms and Function
    Gary Kao; Fiscal Year: 2007
    ..We have previously discovered that human histone deacetylase 4 (HDAC4) is a component of the DNA damage response that contributes to mediating G2/M checkpoints, and promotes the ..
  3. CHARACTERIZATION OF COREPRESSOR N-COR COMPLEXES
    Jiemin Wong; Fiscal Year: 2005
    ..to depend on histone deacetylase (HDAC) activity and involves multiple histone deacetylases including HDAC1/2, HDAC4, HDAC5 and HDAC7...
  4. Histone deacetylase 4 and neural activity-dependent muscle remodeling and atrophy
    Tso Pang Yao; Fiscal Year: 2010
    ..Toward this goal, we have identified HDAC4, a negative regulator of MEF2 transcription factors, as a potential protein critical for neuromuscular activity-..
  5. Regulation of histone deacetylase 7 (HDAC7) activity
    Hung Ying Kao; Fiscal Year: 2006
    ..HDAC7 (Histone deacetylase 7) belongs to the class II HDACs that includes HDAC4, -5, -6, -9, and -10...
  6. CALCIUM/CALMODULIN ACTIVATED KINASES IN SMOOTH MUSCLE
    Harold A Singer; Fiscal Year: 2010
    ..We will test the hypothesis that CaMKII regulates the co-repressors HDAC4 and HDAC5 in synthetic phenotype VSM...
  7. CALCIUM/CALMODULIN ACTIVATED KINASES IN SMOOTH MUSCLE
    HAROLD SINGER; Fiscal Year: 2009
    ..We will test the hypothesis that CaMKII regulates the co-repressors HDAC4 and HDAC5 in synthetic phenotype VSM...
  8. TGF-Beta regulation of Runx2 in bone formation and quality
    Tamara Alliston; Fiscal Year: 2007
    ..Specifically, the repression of Runx2 by Smad3/HDAC4/5 confers TGF-¿ inhibitory signals to osteocalcin and Runx2 expression, and to osteoblast differentiation in ..
  9. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..that promotes Rac1 and PI3K signaling upstream to MKK3 and p38 MARK activation, followed by essential downstream HDAC4 depletion to induce terminal hypertrophic chondrocyte differentiation...
  10. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2007
    ..that promotes Rac1 and PI3K signaling upstream to MKK3 and p38 MARK activation, followed by essential downstream HDAC4 depletion to induce terminal hypertrophic chondrocyte differentiation...
  11. Methionine sulfoxide reductase A and oxidized CaMKII in structural heart disease
    Mark E Anderson; Fiscal Year: 2011
    ..a previously unknown pathway where ox-CaMKII drives myocardial matrix metalloproteinase 9 (MMP9) expression by HDAC4/5 phosphorylation and MEF2 derepression. Aim 2 Determine the role of ox-CaMKII in myocardial hypertrophy...
  12. Design of Class-specific HDAC Imaging Probes for Positron Emission Tomography
    Jacob M Hooker; Fiscal Year: 2010
    ..These tools will be use to accelerate epigenetic research and will ultimately be translated to human PET imaging and clinicians for diagnosing disease and monitoring treatment. ..
  13. REGULATION OF RUNX-2 TRANSCRIPTIONAL ACTIVITY
    Jennifer J Westendorf; Fiscal Year: 2010
    ..We have identified four Hdacs (Hdac3, Hdac4, Hdac6, Hdac7) and the Hdac- associated co-repressor, mSinSA, as Runx2 interacting proteins...
  14. REGULATION OF RUNX-2 TRANSCRIPTIONAL ACTIVITY
    JENNIFER WESTENDORF; Fiscal Year: 2009
    ..We have identified four Hdacs (Hdac3, Hdac4, Hdac6, Hdac7) and the Hdac- associated co-repressor, mSinSA, as Runx2 interacting proteins...
  15. Cellular co-factors in stable retroviral transduction
    Rene Daniel; Fiscal Year: 2007
    ..of the non- homologous end joining (NHEJ) DNA repair pathway (Aim 1), and on the cellular histone deacetylase 4 (HDAC4) protein (Aim 2). Both of these discoveries will be put to use in Aim 3...
  16. Functional Analysis of Histone Deacetylases
    Edward Seto; Fiscal Year: 2006
    ..Particular emphasis will be devoted to a detailed molecular dissection of the human HDAC3 and HDAC4 enzymes, and the elucidation of the molecular mechanisms by which HDAC inhibitors alter gene transcription...
  17. Cellular co-factors in stable retroviral transduction
    Rene Daniel; Fiscal Year: 2010
    ..of the non- homologous end joining (NHEJ) DNA repair pathway (Aim 1), and on the cellular histone deacetylase 4 (HDAC4) protein (Aim 2). Both of these discoveries will be put to use in Aim 3...
  18. Functional Analysis of Histone Deacetylases
    Edward Seto; Fiscal Year: 2003
    ..Particular emphasis will be devoted to a detailed molecular dissection of the human HDAC3 and HDAC4 enzymes, and the elucidation of the molecular mechanisms by which HDAC inhibitors alter gene transcription...
  19. Cardioprotective effects of thioredoxin 1
    Junichi Sadoshima; Fiscal Year: 2010
    ..Furthermore, redox regulation of Dnajb5 and HDAC4 by Trx1 through multi-protein complex formation mediates both subcellular localization and enzyme activity of ..
  20. Activity-dependent regulation of neuromuscular junction formation
    Daniel Goldman; Fiscal Year: 2009
    ..Specifically, we propose to: 1) Evaluate the role Dach2 and MITR play during development of the NMJ; 2) Examine if HDAC4 coordinates Dach2 and MITR gene repression in response to muscle innervation; and 3) Determine if the Dach ..
  21. Activity-dependent regulation of neuromuscular junction formation
    DANIEL J GOLDMAN; Fiscal Year: 2010
    ..Specifically, we propose to: 1) Evaluate the role Dach2 and MITR play during development of the NMJ;2) Examine if HDAC4 coordinates Dach2 and MITR gene repression in response to muscle innervation;and 3) Determine if the Dach ..
  22. Cytoplasmic Cam KIIRegulates Cardiomyocyte Transcription
    STEPHEN GRANT; Fiscal Year: 2006
    ..This phosphorylation leads to dissociation of the complex allowing HDAC4/5 to enter the nucleus and bind MEF2, thereby silencing MEF2-dependent gene transcription (iv) direct ..
  23. Molecular Study of sir-2 genes and Aging in C. elegans
    Leonard Guarente; Fiscal Year: 2006
    ..elegans. They also may shed light on a molecular mechanism of CR in an animal. These findings may have direct relevance to aging and the extension of life span by CR in mammals. ..
  24. CELL/CELL INTERACTION AND PROSTATE GROWTH
    John Isaacs; Fiscal Year: 2000
    ....
  25. CONTROL OF CALCIUM RELEASE IN SKELETAL MUSCLE FIBERS
    Martin F Schneider; Fiscal Year: 2010
    ....
  26. Cellular Response to Retroviral DNA Integration
    Rene Daniel; Fiscal Year: 2007
    ..They should also significantly enhance our understanding of the function of these important cellular pathways. ..
  27. The Role of PARP-SIR2 Signaling in Heart Failure
    Mahesh Gupta; Fiscal Year: 2009
    ..As such, these studies are likely to provide new strategies for the management of heart failure. ..
  28. Studies of the mouse kappa opioid receptor gene
    Li na Wei; Fiscal Year: 2007
    ..This award is also essential for the Pi's continual career development as an independent scientist in the field of drug abuse research. ..
  29. ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATION
    ERIC M VERDIN; Fiscal Year: 2010
    ..These experiments have the potential of identifying novel factors mediating HIV transcriptional regulation that could be targeted therapeutically in the future. ..