Gene Symbol: HDAC3
Description: histone deacetylase 3
Alias: HD3, RPD3, RPD3-2, histone deacetylase 3, SMAP45
Species: human
Products:     HDAC3

Top Publications

  1. Atsumi A, Tomita A, Kiyoi H, Naoe T. Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. Biochem Biophys Res Commun. 2006;345:1471-80 pubmed
    ..Here, we demonstrated that HDAC3, one component of the N-CoR transcription repressor complex, is a key regulator of the transcription repression by ..
  2. Zhang X, Ozawa Y, Lee H, Wen Y, Tan T, Wadzinski B, et al. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 2005;19:827-39 pubmed
    b>Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins...
  3. Spurling C, Godman C, Noonan E, Rasmussen T, Rosenberg D, Giardina C. HDAC3 overexpression and colon cancer cell proliferation and differentiation. Mol Carcinog. 2008;47:137-47 pubmed
    ..analysis of human colorectal adenocarcinomas showed that cancer cells express widely varying levels of HDAC3. The SW480 colon cancer cell line was found to express high levels of HDAC3 compared to other colon cancer cell ..
  4. Gray S, Iglesias A, Lizcano F, Villanueva R, Camelo S, Jingu H, et al. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem. 2005;280:28507-18 pubmed
    ..The ability of JMJD2A to associate with pRb and HDACs and potentiate pRb-mediated repression of E2F-regulated promoters implies an important role for this protein in cell proliferation and oncogenesis. ..
  5. Nevels M, Paulus C, Shenk T. Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. Proc Natl Acad Sci U S A. 2004;101:17234-9 pubmed
    ..Consistent with these findings, IE1 interacts specifically with HDAC3 within infected cells. We also demonstrate an interaction between IE2 and HDAC3...
  6. Zhang J, Kalkum M, Chait B, Roeder R. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell. 2002;9:611-23 pubmed
    ..We report here that GPS2, a protein involved in intracellular signaling, is an integral subunit of the N-CoR-HDAC3 complex...
  7. Murphy J, Fischle W, Verdin E, Sinclair J. Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J. 2002;21:1112-20 pubmed
    ..Non-permissive cells contain the class I HDAC, HDAC3; super-expression of HDAC3 in normally permissive cells reduces infection and MIEP activity...
  8. Zeng Z, Liao R, Yao Z, Zhou W, Ye P, Zheng X, et al. Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: a community-based case-control study. Gene. 2014;533:427-33 pubmed publisher
    ..Four polymorphisms of HDAC1 (rs1741981) and HDAC3 (rs11741808, rs2547547, rs2530223) were examined by the use of TaqMan technology...
  9. Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, et al. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007;27:1280-95 pubmed
    ..In contrast, HDAC3 efficiently deacetylated MEF2D in vitro and in vivo...

More Information


  1. Codina A, Love J, Li Y, Lazar M, Neuhaus D, Schwabe J. Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2005;102:6009-14 pubmed
    ..This role is achieved, in part, through the recruitment of a key histone deacetylase (HDAC3), which is itself indispensable for cell viability...
  2. Yuan Z, Guan Y, Chatterjee D, Chin Y. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005;307:269-73 pubmed
  3. Vidal Laliena M, Gallastegui E, Mateo F, Martínez Balbás M, Pujol M, Bachs O. Histone deacetylase 3 regulates cyclin A stability. J Biol Chem. 2013;288:21096-104 pubmed publisher
    ..We report here that histone deacetylase 3 (HDAC3) directly interacts with and deacetylates cyclin A...
  4. Marban C, Suzanne S, Dequiedt F, De Walque S, Redel L, Van Lint C, et al. Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. EMBO J. 2007;26:412-23 pubmed
    ..Altogether, our findings uncover new therapeutic opportunities for purging latent HIV-1 viruses from their cellular reservoirs. ..
  5. Yoon H, Chan D, Huang Z, Li J, Fondell J, Qin J, et al. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 2003;22:1336-46 pubmed
    ..N-CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC3, TBL1 and TBLR1. However, the roles of these proteins in SMRT-N-CoR complex function are largely unknown...
  6. Villagra A, Sotomayor E, Seto E. Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene. 2010;29:157-73 pubmed publisher
    ..This emerging knowledge is opening new avenues to better understand epigenetic regulation of inflammatory responses and providing new molecular targets for either amplifying or ameliorating immune responses. ..
  7. Hurst D, Mehta A, Moore B, Phadke P, Meehan W, Accavitti M, et al. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun. 2006;348:1429-35 pubmed
    ..We further found that BRMS1 is stabilized by Hsp90, and its turnover is proteasome dependent. The stability of BRMS1 protein may be important in maintaining the functional role of BRMS1 in metastasis suppression. ..
  8. Chini C, Escande C, Nin V, Chini E. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem. 2010;285:40830-7 pubmed publisher
    b>HDAC3 is a member of the class I histone deacetylase family that regulates gene expression by deacetylation of histones and non-histone proteins...
  9. Yang W, Tsai S, Wen Y, Fejer G, Seto E. Functional domains of histone deacetylase-3. J Biol Chem. 2002;277:9447-54 pubmed
    ..In humans, four highly homologous class I HDAC enzymes (HDAC1, HDAC2, HDAC3, and HDAC8) have been identified to date...
  10. Guenther M, Yu J, Kao G, Yen T, Lazar M. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 2002;16:3130-5 pubmed
    The acetylation of histone tails is a primary determinant of gene activity. Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for HDAC enzyme activity...
  11. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  12. Ishii S, Kurasawa Y, Wong J, Yu Lee L. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc Natl Acad Sci U S A. 2008;105:4179-84 pubmed publisher
    Protein acetylation and deacetylation play key roles in multiple physiological functions. Histone deacetylase 3 (HDAC3) is a highly conserved, ubiquitously expressed protein that forms multiprotein corepressor complexes to repress gene ..
  13. Wen Y, Perissi V, Staszewski L, Yang W, Krones A, Glass C, et al. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2000;97:7202-7 pubmed
    ..N-CoR also interacts with class II deacetylases HDAC4, HDAC5, and HDAC7. In comparison with HDAC1 and HDAC2, HDAC3 remains relatively uncharacterized, and very few proteins have been shown to interact with HDAC3...
  14. Chen Lf -, Fischle W, Verdin E, Greene W. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science. 2001;293:1653-7 pubmed
    ..Acetylated RelA is subsequently deacetylated through a specific interaction with histone deacetylase 3 (HDAC3)...
  15. Guenther M, Lane W, Fischle W, Verdin E, Lazar M, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 2000;14:1048-57 pubmed
    ..It also contains HDAC3, a histone deacetylase not previously thought to interact with SMRT...
  16. Watson P, Fairall L, Santos G, Schwabe J. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature. 2012;481:335-40 pubmed publisher
    ..Here we report the structure of a complex between an HDAC and a co-repressor, namely, human HDAC3 with the deacetylase activation domain (DAD) from the human SMRT co-repressor (also known as NCOR2)...
  17. Li G, Franco P, Wei L. Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2. Biochem Biophys Res Commun. 2003;310:384-90 pubmed
    The orphan nuclear receptor TR2 interacts directly with histone deacetylase HDAC3 and HDAC4. We now report that two domains of HDAC3 are involved in its interaction with TR2...
  18. Nakagawa M, Oda Y, Eguchi T, Aishima S, Yao T, Hosoi F, et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep. 2007;18:769-74 pubmed
    ..Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers. ..
  19. Fritzsche F, Weichert W, Röske A, Gekeler V, Beckers T, Stephan C, et al. Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer. BMC Cancer. 2008;8:381 pubmed publisher
    ..Whether HDAC expression in renal cancers is predictive of responsiveness for HDI will have to be tested in further studies. ..
  20. Wu W, Vallian S, Seto E, Yang W, Edmondson D, Roth S, et al. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001;21:2259-68 pubmed
    ..Together, the results of our study show that PML modulates histone deacetylation and that loss of this function in APL alters chromatin remodeling and gene expression. This event may contribute to the development of leukemia. ..
  21. Mahlknecht U, Emiliani S, Najfeld V, Young S, Verdin E. Genomic organization and chromosomal localization of the human histone deacetylase 3 gene. Genomics. 1999;56:197-202 pubmed
    ..We have isolated and sequenced a genomic clone for the human HDAC3 gene. This is a single-copy gene spanning a region of at least 13 kb...
  22. Jeyakumar M, Liu X, Erdjument Bromage H, Tempst P, Bagchi M. Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem. 2007;282:9312-22 pubmed
    ..A subset of TR.RXR-associated polypeptides included NCoR, SMRT, TBL1, and HDAC3, which represent the core components of a previously described NCoR/SMRT corepressor complex...
  23. Sankar N, Baluchamy S, Kadeppagari R, Singhal G, Weitzman S, Thimmapaya B. p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc. Oncogene. 2008;27:5717-28 pubmed publisher
    ..studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300 cooperates with histone deacetylase 3 (HDAC3) to repress transcription...
  24. Li J, Wang J, Nawaz Z, Liu J, Qin J, Wong J. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 2000;19:4342-50 pubmed
    ..and immunoaffinity chromatography, we have successfully isolated a SMRT complex and identified histone deacetylase 3 (HDAC3) and transducin (beta)-like I (TBL1), a WD-40 repeat-containing protein, as the subunits of the ..
  25. Wei L, Hu X, Chandra D, Seto E, Farooqui M. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem. 2000;275:40782-7 pubmed
    ..Direct interaction of RIP140 with HDAC1 and HDAC3 occurs in vitro and in vivo as demonstrated in co-immunoprecipitation and glutathione S-transferase pull-down ..
  26. Mostaqul Huq M, Gupta P, Tsai N, White R, Parker M, Wei L. Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J. 2006;25:5094-104 pubmed
    ..This study uncovered a novel means to inactivate, or suppress, RIP140, and demonstrated protein arginine methylation as a critical type of modification for corepressor. ..
  27. Yang W, Yao Y, Sun J, Davie J, Seto E. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem. 1997;272:28001-7 pubmed
    Several human cDNAs encoding a histone deacetylase protein, HDAC3, have been isolated. Analysis of the predicted amino acid sequence of HDAC3 revealed an open reading frame of 428 amino acids with a predicted molecular mass of 49 kDa...
  28. Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, et al. Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor ?2. J Biol Chem. 2013;288:31853-66 pubmed publisher
    b>Histone deacetylase 3 (HDAC3) plays a critical role in the maintenance of endothelial integrity and other physiological processes...
  29. Zhang F, Shi Y, Wang L, Sriram S. Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. PLoS ONE. 2011;6:e16795 pubmed publisher
    b>Histone deacetylase 3 (HDAC3) belongs to a family of proteins which plays an important role in protein acetylation, chromatin remodeling and transcription of genes, including those that are involved in cell proliferation and cell death...
  30. Guenther M, Barak O, Lazar M. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol. 2001;21:6091-101 pubmed
    ..In vivo, HDAC3 forms a stable complex with the SMRT corepressor...
  31. Hoberg J, Yeung F, Mayo M. SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell. 2004;16:245-55 pubmed
    ..IKKalpha-induced phosphorylation coincides with a loss of chromatin-associated SMRT and HDAC3 and with nuclear export of the SMRT corepressor, events required for expression of the NF-kappaB-regulated cIAP-2 ..
  32. Mahlknecht U, Will J, Varin A, Hoelzer D, Herbein G. Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. J Immunol. 2004;173:3979-90 pubmed
    ..Results further indicated that HDAC3 decreases the MAPK11 phosphorylation state and inhibits the activity of the MAPK11-dependent transcription factor, ..
  33. Meier B, Wagner B. Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics. Epigenomics. 2014;6:209-14 pubmed publisher
    ..Evidence suggests that inhibition of HDAC3 protects ?-cells from cytokine-induced apoptosis, an important event in the development of Type 1 diabetes...
  34. Longworth M, Laimins L. Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 2006;25:4495-500 pubmed
    ..b>Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the ..
  35. Escaffit F, Vaute O, Chevillard Briet M, Segui B, Takami Y, Nakayama T, et al. Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression. Mol Cell Biol. 2007;27:554-67 pubmed
    ..Here, we show that the histone deacetylase 3 (HDAC-3), which is a known co-repressor of many proapoptotic genes, is subjected to proteolytic cleavage ..
  36. Alam S, Li H, Margariti A, Martin D, Zampetaki A, Habi O, et al. Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3. J Biol Chem. 2011;286:44211-7 pubmed publisher
    ..When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-?-induced galectin-9 expression was abolished...
  37. Sanyal S, Båvner A, Haroniti A, Nilsson L, Lundåsen T, Rehnmark S, et al. Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. Proc Natl Acad Sci U S A. 2007;104:15665-70 pubmed
  38. Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, et al. Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010;121:132-42 pubmed publisher
    b>Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood...
  39. Nicolas E, Ait Si Ali S, Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res. 2001;29:3131-6 pubmed
    ..mediated, at least in part, by a histone deacetylase complex, whose enzymatic activity relies on HDAC1, HDAC2 or HDAC3. Recently, we have shown that the Rb-associated histone deacetylase complex contains RbAp48 protein, which ..
  40. Tussie Luna M, Bayarsaihan D, Seto E, Ruddle F, Roy A. Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc Natl Acad Sci U S A. 2002;99:12807-12 pubmed
    ..Here, we show that TFII-I and its related member hMusTRD1/BEN physically and functionally interact with HDAC3. The TFII-I family proteins and HDAC3 also show nearly identical expression patterns in early mouse development...
  41. Weichert W, Röske A, Niesporek S, Noske A, Buckendahl A, Dietel M, et al. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res. 2008;14:1669-77 pubmed publisher
    ..4%, HDAC2 in 57.9%, and HDAC3 in 72.9% of cases. Expression was significantly enhanced in strongly proliferating (P = 0...
  42. Kim H, Choi K, Choi H, Kang H, Kim M, Lee Y, et al. HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. Cell Mol Life Sci. 2010;67:3499-510 pubmed publisher
    We identified CREB3 as a novel HDAC3-interacting protein in a yeast two-hybrid screen for HDAC3-interacting proteins. Among all class I HDACs, CREB3 specifically interacts with HDAC3, in vitro and in vivo...
  43. Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer. 2008;98:604-10 pubmed publisher
    ..Class I HDAC isoforms were strongly expressed in the majority of the cases (HDAC1: 69.8%, HDAC2: 74%, HDAC3: 94.8%). High rates of HDAC1 and HDAC2 expression were significantly associated with tumour dedifferentiation...
  44. Buurman R, Sandbothe M, Schlegelberger B, Skawran B. HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma. Eur J Med Res. 2016;21:26 pubmed publisher
    ..We have previously shown that HDAC1, HDAC2, and HDAC3 (HDAC1-3) genes encoding histone deacetylases 1-3 are upregulated in primary human hepatocellular carcinoma (HCC)...
  45. Jones J, Singh P, Govind C. Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide. PLoS ONE. 2016;11:e0148897 pubmed publisher
    ..that Cmr1 recruitment to coding sequences is stimulated by Pol II CTD kinase, Kin28, and the histone deacetylases, Rpd3 and Hos2...
  46. Zhang T, Sheng Z, Du W. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mech Dev. 2016;141:4-13 pubmed publisher
    ..In this study, we show that inactivation of Rpd3, the only HDAC1 and HDAC2 ortholog in Drosophila, induced apoptosis and clone elimination in the developing eye and ..
  47. Martire S, Banaszynski L. Checks and Balances: Rpd3 Issues Executive Orders in Developmental Enhancer Regulation. Dev Cell. 2017;40:325-326 pubmed publisher
    ..In this issue of Developmental Cell, Janssens et al. (2017) demonstrate that the erm enhancer is maintained in a poised state in neural stem cells by the histone deacetylase Hdac1/Rpd3.
  48. Lu J, McKinsey T, Zhang C, Olson E. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol Cell. 2000;6:233-44 pubmed
    ..These findings reveal central roles for HDACs in chromatin remodeling during myogenesis and as intranuclear targets for signaling pathways controlled by IGF and CaM kinase. ..
  49. Choo M, Yeo H, Zayzafoon M. NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone. 2009;45:579-89 pubmed publisher
    ..we show by Chromatin Immunoprecipitation (ChIP) assay that the overexpression of NFATc1 sustains the binding of HDAC3 on the proximal region of the osteocalcin promoter, resulting in complete hypoacetylation of histones H3 and H4 ..
  50. Soriano F, Hardingham G. In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export. PLoS ONE. 2011;6:e21056 pubmed publisher
    ..SMRT is a multi-domain protein that complexes with HDAC3 as well as being capable of interactions with HDACs 1, 4, 5 and 7...
  51. Rajendran P, Delage B, Dashwood W, Yu T, Wuth B, Williams D, et al. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer. 2011;10:68 pubmed publisher
    ..There was a time-dependent loss of class I and selected class II HDAC proteins, with HDAC3 depletion detected ahead of other HDACs...
  52. Liang J, Lei T, Song Y, Yanes N, Qi Y, Fu M. RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling. J Biol Chem. 2009;284:29383-90 pubmed publisher
    ..Treatment with histone deacetylase inhibitors or small interfering RNA induced HDAC1 or HDAC3 knockdown completely or partly abolished the inhibitory activity of TTP on NF-kappaB reporter activation...
  53. Li Z, Dong M, Fan D, Hou P, Li H, Liu L, et al. LncRNA ANCR down-regulation promotes TGF-?-induced EMT and metastasis in breast cancer. Oncotarget. 2017;8:67329-67343 pubmed publisher
    ..By our ChIP and Real-time PCR assays, we reveal that TGF-?1 down-regulates ANCR expression by increasing HDAC3 enrichment at ANCR promoter region, which decreases both H3 and H4 acetylation of ANCR promoter...
  54. Guo J, Hu Z, Yu X, Li A, Li F, Wang Y, et al. A histone deacetylase gene, SlHDA3, acts as a negative regulator of fruit ripening and carotenoid accumulation. Plant Cell Rep. 2018;37:125-135 pubmed publisher
    ..With the aim of characterizing the tomato RPD3/HDA1 family histone deacetylase genes, SlHDA3 was isolated and its RNA interference (RNAi) lines was obtained...
  55. Booth L, Roberts J, Poklepovic A, Kirkwood J, Dent P. HDAC inhibitors enhance the immunotherapy response of melanoma cells. Oncotarget. 2017;8:83155-83170 pubmed publisher
    ..Knock down of HDAC1, HDAC3, HDAC8 and HDAC10, but not HDAC6, recapitulated the effects of the HDAC inhibitors on the immunotherapy biomarkers...
  56. Kyle S, Saha P, Brown H, CHAN L, Justice M. MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Hum Mol Genet. 2016;25:3029-3041 pubmed
    ..We show that MeCP2 regulates lipid homeostasis by anchoring the repressor complex containing NCoR1 and HDAC3 to its lipogenesis targets in hepatocytes...
  57. Soma M, Wang M, Suo S, Ishiura S. Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3. Neurosci Lett. 2014;582:120-4 pubmed publisher
    ..Several studies have shown that both dysbindin-1 and histone deacetylase 3 (HDAC3) can be phosphorylated by the DNA-dependent protein kinase complex...
  58. Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. Histone deacetylase 3 associates with and represses the transcription factor GATA-2. Blood. 2001;98:2116-23 pubmed
    ..GATA-2 directly associates with HDAC3 but not with HDAC1...
  59. Fischle W, Dequiedt F, Fillion M, Hendzel M, Voelter W, Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001;276:35826-35 pubmed
    ..activity of HDAC7 maps to a carboxyl-terminal domain and is dependent on the interaction with the class I HDAC, HDAC3, in the cell nucleus. Cytoplasmic HDAC7 that is not bound to HDAC3 is enzymatically inactive...
  60. Park H, Kim J, Jung Y, Park C. Racial Differences in the Extracellular Matrix and Histone Acetylation of the Lamina Cribrosa and Peripapillary Sclera. Invest Ophthalmol Vis Sci. 2017;58:4143-4154 pubmed publisher
    ..Histone modification was assessed for histone deacetylase (HDAC) 2, HDAC3, and acetylated histone H3...
  61. Ichijo T, Voutetakis A, Cotrim A, Bhattachryya N, Fujii M, Chrousos G, et al. The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications. J Biol Chem. 2005;280:42067-77 pubmed
    ..Smad6 suppresses GR-induced transactivation by attracting histone deacetylase 3 to DNA-bound GR and by antagonizing acetylation of histone H3 and H4 induced by p160 histone ..
  62. Tsai C, Kao H, Mitzutani A, Banayo E, Rajan H, McKeown M, et al. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc Natl Acad Sci U S A. 2004;101:4047-52 pubmed
    ..transcriptional corepressor SMRT (silencing mediator of retinoid and thyroid hormone receptors) and with histone deacetylase 3. Atx1 binds chromosomes and mediates transcriptional repression when tethered to DNA...