Research Topics
| HD PTPSummaryGene Symbol: HD PTP Description: protein tyrosine phosphatase, non-receptor type 23 Alias: HD-PTP, HDPTP, PTP-TD14, His-domain protein tyrosine phosphatase, his domain-containing protein tyrosine phosphatase, protein tyrosine phosphatase TD14, tyrosine-protein phosphatase non-receptor type 23 Species: human Top Publications
Research Grants
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Detail Information
Publications
HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3S Toyooka
Department of Surgery II, Okayama University Medical School, Okayama, 700 8558, Japan
Biochem Biophys Res Commun 278:671-8. 2000..We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3...
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domainMarie Claude Gingras
Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
PLoS ONE 4:e5105. 2009..To date, no HD-PTP phosphorylated substrate has been identified and controversial results concerning its catalytic activity have been recently reported...
Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTPMassimo Mariotti
Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
Cancer Lett 273:155-63. 2009..Following stimulation with EGF, HD-PTP is tyrosine-phosphorylated and releases FAK which will ultimately contribute to the turn-over of focal adhesion and, therefore, to cell motility...- The tyrosine phosphatase HD-PTP: A novel player in endothelial migrationSara Castiglioni
Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
Biochem Biophys Res Commun 364:534-9. 2007..We suggest that HD-PTP contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of FAK... - HD-PTP inhibits endothelial migration through its interaction with SrcMassimo Mariotti
Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
Int J Biochem Cell Biol 41:687-93. 2009.... - Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2Maria Harkiolaki
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX37BN, UK
Structure 17:809-22. 2009..In summary, our study reveals interaction types of SH3 domains, highlighting their great versatility... - Search for sarcoidosis candidate genes by integration of data from genomic, transcriptomic and proteomic studiesAles Maver
Department of Obstetrics and Gynecology, Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia
Med Sci Monit 15:SR22-8. 2009.... - Downregulation of HD-PTP by high magnesium concentration: novel insights into magnesium-induced endothelial migrationMarzia Leidi
Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Milano, Italy
Magnes Res 23:119-25. 2010..Our results indicate that, in the presence of high magnesium concentrations, endothelial cells are stimulated to migrate through complex mechanisms involving also HD-PTP... - Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafishMark van Eekelen
Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 5:e12573. 2010..This is the first time the expression patterns of all members of the large family of PTP genes have been established in a vertebrate. Our results provide the first step towards elucidation of the function of the family of classical PTPs... - Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpLCarmen Alexandra Tanase
Department of Enzymology, Institute of Biochemistry, Bucharest, Romania
PLoS ONE 5:e14339. 2010..Although it is a large protein with at least five distinct structural domains, only a few of its interactors are presently known, and the significance of these interactions is largely obscure... - A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein YorkieM Melissa Gilbert
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Dev Cell 20:700-12. 2011..These data establish Myopic as a Yorkie regulator and implicate Myopic-dependent association of Yorkie with endosomal compartments as a regulatory step in nuclear outputs of the SWH pathway... - Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'Guang Lin
Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York 11794, USA
Genes Dev 25:1412-25. 2011..In addition, our studies highlight functional specificity among PTPs and reveal new roles for PTPs in mammary epithelial cell biology... - UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sortingFlavia Stefani
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Curr Biol 21:1245-50. 2011..UBAP1 binds the endosomal Bro1 protein His domain protein tyrosine phosphatase (HDPTP), but not Alix, a Bro1 protein involved in cytokinesis... - The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 releasePaola Sette
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Structure 19:1485-95. 2011..These studies identify a new functional determinant in the Bro1 domain of Alix... - Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle productionSergei Popov
University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Virol 83:7185-93. 2009..Unexpectedly, Brox retained significant activity even if its CHMP4 binding site was disrupted. Thus, the ability to assist in VLP production may be an intrinsic property of the boomerang-shaped Bro1 domain... - Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP)Marie Claude Gingras
Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Int J Dev Biol 53:1069-74. 2009..Our results show that Ptpn23 is expressed early during mouse development and that its expression is maintained in adult tissues, markedly in the epithelial cells of many organs... - Spermatogonia-dependent expression of testicular genes in miceKiyoko Tanaka
Department of Tumor Biochemistry, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
Dev Biol 246:466-79. 2002..encoding lipocalin family members (prostaglandin D synthetase and 24p3) and 2 tumor suppressors (protein tyrosine phosphatase TD14 and Sui1)... - Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTPMassimo Mariotti
Department of Preclinical Sciences, University of Milan Medical School, Italy
J Cell Biochem 98:301-8. 2006..These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels... - The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradationMassimo Mariotti
Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
Front Biosci 11:2138-43. 2006..HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor does not affect protein levels, Fibroblast Growth Factor-2 induces HD-PTP degradation via the proteasome system... - HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regionsFumitaka Ichioka
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
Arch Biochem Biophys 457:142-9. 2007..While Alix associated with both ALG-2 and TSG101 in a Ca2+-dependent manner, HD-PTP interacted with ALG-2 Ca2+-dependently but with TSG101 Ca2+-independently... - Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptorGrant I Miura
Kimmel Center for Biology and Medicine of the Skirball Institute, NYU School of Medicine, Department of Cell Biology, 540 First Avenue, New York, NY 10016, USA
Development 135:1913-22. 2008..Loss of Myopic prevents cleavage of the EGFR cytoplasmic domain, a process controlled by the endocytic regulators Cbl and Sprouty. We suggest that Myopic promotes EGFR signaling by mediating its progression through the endocytic pathway... - The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesisAurelie Doyotte
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Proc Natl Acad Sci U S A 105:6308-13. 2008..Rescue experiments using an RNAi-resistant version of HD-PTP and HD-PTP mutants demonstrated an essential role for the HD-PTP Bro1 domain, with ESCRT-III binding correlating with full biological activity... - Screening of LRRK2 interactants by yeast 2-hybrid analysisXiao ye Zheng
National Laboratory of Medical Genetics, Central South University, Changsha 410078, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:883-91. 2008..To isolate and identify the potential binding partners of LRRK2, a gene linked to both dominant familial form and sporadic form of Parkinson's disease, thus to further our knowledge of its function... - Large-scale structural analysis of the classical human protein tyrosine phosphatomeAlastair J Barr
University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
Cell 136:352-63. 2009..Enzymatic assays revealed vast differences in PTP catalytic activity and identified PTPD1, PTPD2, and HDPTP as catalytically inert protein phosphatases... - A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformationL Cao
Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
J Biol Chem 273:21077-83. 1998..These findings indicate that PTP-TD14 encodes a novel protein that may be critically involved in regulating Ha-ras-dependent cell growth... - Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 buddingQianting Zhai
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS ONE 6:e27466. 2011....
Research Grants
- PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTIONNicholas K Tonks; Fiscal Year: 2010....
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTJames Frederick; Fiscal Year: 2007..With the HDPTP supplement the TMC will help protect workers and community residents from potential exposures to hazardous ..
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTWILLIAM BORWEGEN; Fiscal Year: 2007..Center (SWEC), are applying for a grant under the HWWTP for 5 years at a total cost of $4,229,261 and the HDPTP for 5 years at a total cost of $1,580,584...
- WORKER HEALTH AND SAFETY COOPERATIVE AGREEMENTFRANK CYPHERS; Fiscal Year: 2007..The HDPTP aims include, continuing WMD First Receivers training and expanding to Disaster Site Worker training, Worker and ..
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTDOUGLAS FEIL; Fiscal Year: 2007..The goal of CCCHST-HDPTP is to train a minimum of 10,000 workers and provide a total 30,000 contact hours of instruction in Hazmat Disaster ..
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTBarbara McCabe; Fiscal Year: 2007..The target audience for the HDPTP is the same as the HWWTP, but includes, in addition, 60,000 Transport Workers Union employees that operate subways ..
- Hazardous Waste Worker Training ProgramJOHN LECONCHE; Fiscal Year: 2007..Hazardous Waste Worker Training Program (HWWTP - $24,169,912) and a Hazmat Disaster Preparedness Training Program (HDPTP - $2,341,200), at a total cost of $26,511,112 over the five years of the program...
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTCarol Rice; Fiscal Year: 2007..provided by applicant) The Midwest Consortium for Hazardous Waste Worker Training will conduct HWWT and HDPTP programs...
- WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENTPatrick Morrison; Fiscal Year: 2007..program areas; Hazardous Waste Worker Training Program (HWWTP) and Hazmat Disaster Preparedness Training Program (HDPTP)...