HD PTP

Summary

Gene Symbol: HD PTP
Description: protein tyrosine phosphatase, non-receptor type 23
Alias: HD-PTP, HDPTP, PTP-TD14, His-domain protein tyrosine phosphatase, his domain-containing protein tyrosine phosphatase, protein tyrosine phosphatase TD14, tyrosine-protein phosphatase non-receptor type 23
Species: human

Top Publications

  1. ncbi HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3
    S Toyooka
    Department of Surgery II, Okayama University Medical School, Okayama, 700 8558, Japan
    Biochem Biophys Res Commun 278:671-8. 2000
  2. pmc Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production
    Sergei Popov
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 83:7185-93. 2009
  3. ncbi HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions
    Fumitaka Ichioka
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Arch Biochem Biophys 457:142-9. 2007
  4. ncbi The tyrosine phosphatase HD-PTP: A novel player in endothelial migration
    Sara Castiglioni
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Biochem Biophys Res Commun 364:534-9. 2007
  5. pmc HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain
    Marie Claude Gingras
    Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e5105. 2009
  6. doi HD-PTP inhibits endothelial migration through its interaction with Src
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    Int J Biochem Cell Biol 41:687-93. 2009
  7. doi Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Cancer Lett 273:155-63. 2009
  8. doi Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB
    Nazim Ali
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 23:453-61. 2013
  9. doi The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration
    Dong Yuan Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Cell Sci 125:4841-52. 2012
  10. doi The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner
    Sara Castiglioni
    Department of Clinical Sciences L Sacco, Universita di Milano, Via GB Grassi, 74 Milano, Italy
    Biochem Biophys Res Commun 421:380-3. 2012

Scientific Experts

  • Massimo Mariotti
  • K Tanaka
  • Jeanette A M Maier
  • Carmen Alexandra Tanase
  • M Melissa Gilbert
  • Alastair J Barr
  • Carol Rice
  • WILLIAM BORWEGEN
  • DOUGLAS FEIL
  • James Frederick
  • JOHN LECONCHE
  • FRANK CYPHERS
  • LARRY GREGOIRE
  • Barbara McCabe
  • DAVID TREANOR
  • Patrick J Morrison
  • DAVID NEUN
  • Patrick Morrison
  • Nicholas K Tonks
  • JAMES S FREDERICK
  • ERIC LAMAR
  • BARBARA ANN MCCABE
  • ERICH STAFFORD
  • JOHN J LECONCHE
  • Ronald Snyder
  • Robert J Emery
  • FRANK STEPHEN CYPHERS
  • Sara Castiglioni
  • Marie Claude Gingras
  • Philip Woodman
  • Aurelie Doyotte
  • Nazim Ali
  • Dong Yuan Chen
  • Sandra Taylor
  • Ling Zhang
  • Qianting Zhai
  • Guang Lin
  • Flavia Stefani
  • Paola Sette
  • Marzia Leidi
  • Mark van Eekelen
  • Ales Maver
  • Maria Harkiolaki
  • Arnim Pause
  • Michel L Tremblay
  • Dmitri Kharitidi
  • Sergei Popov
  • Grant I Miura
  • Xiao ye Zheng
  • Fumitaka Ichioka
  • Alex Mironov
  • Sylvie Urbé
  • Tzu Ching Meng
  • Yu Tsen Lin
  • Sung Po Tsai
  • Jean Cheng Kuo
  • Shih Yun Wu
  • Guang Chao Chen
  • Meng Yen Li
  • Yu Ling Lin
  • Pei Lun Lai
  • Stuart Pickering-Brown
  • Howard Robinson
  • Michael B Landesman
  • Tsan Sam Xiao
  • Victoria Aranda
  • Kim Brownhill
  • Greg Snyder
  • Johanna Donovan
  • Janis Bennion
  • Ruiling Mu
  • Fadila Bouamr
  • Sara Rollinson
  • Christopher P Hill
  • Senthil K Muthuswamy
  • Vincent Dussupt
  • Jiansheng Jiang
  • Patrick Smith
  • Wesley I Sundquist
  • Erika Baldoli
  • John Overvoorde
  • Jeroen den Hertog
  • Carina van Rooijen
  • S Toyooka
  • Stephan M Feller
  • Marc Lewitzky
  • Borut Peterlin
  • Theodora Tsirka
  • Louise E Bird
  • Yu Ling Zhang

Detail Information

Publications30

  1. ncbi HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3
    S Toyooka
    Department of Surgery II, Okayama University Medical School, Okayama, 700 8558, Japan
    Biochem Biophys Res Commun 278:671-8. 2000
    ..We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3...
  2. pmc Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production
    Sergei Popov
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 83:7185-93. 2009
    ..Unexpectedly, Brox retained significant activity even if its CHMP4 binding site was disrupted. Thus, the ability to assist in VLP production may be an intrinsic property of the boomerang-shaped Bro1 domain...
  3. ncbi HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions
    Fumitaka Ichioka
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Arch Biochem Biophys 457:142-9. 2007
    ..While Alix associated with both ALG-2 and TSG101 in a Ca2+-dependent manner, HD-PTP interacted with ALG-2 Ca2+-dependently but with TSG101 Ca2+-independently...
  4. ncbi The tyrosine phosphatase HD-PTP: A novel player in endothelial migration
    Sara Castiglioni
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Biochem Biophys Res Commun 364:534-9. 2007
    ..We suggest that HD-PTP contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of FAK...
  5. pmc HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain
    Marie Claude Gingras
    Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e5105. 2009
    ..To date, no HD-PTP phosphorylated substrate has been identified and controversial results concerning its catalytic activity have been recently reported...
  6. doi HD-PTP inhibits endothelial migration through its interaction with Src
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi 74, Milan, Italy
    Int J Biochem Cell Biol 41:687-93. 2009
    ....
  7. doi Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Cancer Lett 273:155-63. 2009
    ..Following stimulation with EGF, HD-PTP is tyrosine-phosphorylated and releases FAK which will ultimately contribute to the turn-over of focal adhesion and, therefore, to cell motility...
  8. doi Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB
    Nazim Ali
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 23:453-61. 2013
    ..A central question is how EGFR transits vectorially from early, ubiquitin-binding ESCRTs to the final complex, ESCRT-III, such that cargo sequestration is coupled with intralumenal vesicle formation...
  9. doi The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration
    Dong Yuan Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Cell Sci 125:4841-52. 2012
    ..identified one role that Myopic (Mop), the Drosophila homolog of the human His domain phosphotyrosine phosphatase (HDPTP), plays in cell adhesion...
  10. doi The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner
    Sara Castiglioni
    Department of Clinical Sciences L Sacco, Universita di Milano, Via GB Grassi, 74 Milano, Italy
    Biochem Biophys Res Commun 421:380-3. 2012
    ....
  11. pmc Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA
    Kiyoko Tanaka
    Stem Cell Project Group, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    J Biol Chem 288:23990-9. 2013
    ..These data suggest that PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of TGCTs. ..
  12. ncbi Screening of LRRK2 interactants by yeast 2-hybrid analysis
    Xiao ye Zheng
    National Laboratory of Medical Genetics, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:883-91. 2008
    ..To isolate and identify the potential binding partners of LRRK2, a gene linked to both dominant familial form and sporadic form of Parkinson's disease, thus to further our knowledge of its function...
  13. ncbi Spermatogonia-dependent expression of testicular genes in mice
    Kiyoko Tanaka
    Department of Tumor Biochemistry, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Dev Biol 246:466-79. 2002
    ..encoding lipocalin family members (prostaglandin D synthetase and 24p3) and 2 tumor suppressors (protein tyrosine phosphatase TD14 and Sui1)...
  14. ncbi Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Italy
    J Cell Biochem 98:301-8. 2006
    ..These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels...
  15. ncbi The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation
    Massimo Mariotti
    Department of Preclinical Sciences, University of Milan Medical School, Via GB Grassi, 74 Milan, Italy
    Front Biosci 11:2138-43. 2006
    ..HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor does not affect protein levels, Fibroblast Growth Factor-2 induces HD-PTP degradation via the proteasome system...
  16. pmc Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding
    Qianting Zhai
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e27466. 2011
    ....
  17. pmc The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release
    Paola Sette
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 19:1485-95. 2011
    ..These studies identify a new functional determinant in the Bro1 domain of Alix...
  18. doi UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting
    Flavia Stefani
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Curr Biol 21:1245-50. 2011
    ..UBAP1 binds the endosomal Bro1 protein His domain protein tyrosine phosphatase (HDPTP), but not Alix, a Bro1 protein involved in cytokinesis...
  19. pmc Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'
    Guang Lin
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York 11794, USA
    Genes Dev 25:1412-25. 2011
    ..In addition, our studies highlight functional specificity among PTPs and reveal new roles for PTPs in mammary epithelial cell biology...
  20. pmc A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Cell 20:700-12. 2011
    ..These data establish Myopic as a Yorkie regulator and implicate Myopic-dependent association of Yorkie with endosomal compartments as a regulatory step in nuclear outputs of the SWH pathway...
  21. pmc Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
    Carmen Alexandra Tanase
    Department of Enzymology, Institute of Biochemistry, Bucharest, Romania
    PLoS ONE 5:e14339. 2010
    ..Although it is a large protein with at least five distinct structural domains, only a few of its interactors are presently known, and the significance of these interactions is largely obscure...
  22. pmc Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish
    Mark van Eekelen
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e12573. 2010
    ..This is the first time the expression patterns of all members of the large family of PTP genes have been established in a vertebrate. Our results provide the first step towards elucidation of the function of the family of classical PTPs...
  23. doi Downregulation of HD-PTP by high magnesium concentration: novel insights into magnesium-induced endothelial migration
    Marzia Leidi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Milano, Italy
    Magnes Res 23:119-25. 2010
    ..Our results indicate that, in the presence of high magnesium concentrations, endothelial cells are stimulated to migrate through complex mechanisms involving also HD-PTP...
  24. ncbi Search for sarcoidosis candidate genes by integration of data from genomic, transcriptomic and proteomic studies
    Ales Maver
    Department of Obstetrics and Gynecology, Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Med Sci Monit 15:SR22-8. 2009
    ....
  25. doi Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
    Maria Harkiolaki
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX37BN, UK
    Structure 17:809-22. 2009
    ..In summary, our study reveals interaction types of SH3 domains, highlighting their great versatility...
  26. pmc Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor
    Grant I Miura
    Kimmel Center for Biology and Medicine of the Skirball Institute, NYU School of Medicine, Department of Cell Biology, 540 First Avenue, New York, NY 10016, USA
    Development 135:1913-22. 2008
    ..Loss of Myopic prevents cleavage of the EGFR cytoplasmic domain, a process controlled by the endocytic regulators Cbl and Sprouty. We suggest that Myopic promotes EGFR signaling by mediating its progression through the endocytic pathway...
  27. doi Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP)
    Marie Claude Gingras
    Goodman Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Int J Dev Biol 53:1069-74. 2009
    ..Our results show that Ptpn23 is expressed early during mouse development and that its expression is maintained in adult tissues, markedly in the epithelial cells of many organs...
  28. pmc The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis
    Aurelie Doyotte
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 105:6308-13. 2008
    ..Rescue experiments using an RNAi-resistant version of HD-PTP and HD-PTP mutants demonstrated an essential role for the HD-PTP Bro1 domain, with ESCRT-III binding correlating with full biological activity...
  29. pmc Large-scale structural analysis of the classical human protein tyrosine phosphatome
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Cell 136:352-63. 2009
    ..Enzymatic assays revealed vast differences in PTP catalytic activity and identified PTPD1, PTPD2, and HDPTP as catalytically inert protein phosphatases...
  30. ncbi A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation
    L Cao
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    J Biol Chem 273:21077-83. 1998
    ..These findings indicate that PTP-TD14 encodes a novel protein that may be critically involved in regulating Ha-ras-dependent cell growth...

Research Grants59

  1. PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTION
    Nicholas K Tonks; Fiscal Year: 2010
    ....
  2. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    James Frederick; Fiscal Year: 2007
    ..With the HDPTP supplement the TMC will help protect workers and community residents from potential exposures to hazardous ..
  3. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    WILLIAM BORWEGEN; Fiscal Year: 2007
    ..Center (SWEC), are applying for a grant under the HWWTP for 5 years at a total cost of $4,229,261 and the HDPTP for 5 years at a total cost of $1,580,584...
  4. WORKER HEALTH AND SAFETY COOPERATIVE AGREEMENT
    FRANK CYPHERS; Fiscal Year: 2007
    ..The HDPTP aims include, continuing WMD First Receivers training and expanding to Disaster Site Worker training, Worker and ..
  5. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    DOUGLAS FEIL; Fiscal Year: 2007
    ..The goal of CCCHST-HDPTP is to train a minimum of 10,000 workers and provide a total 30,000 contact hours of instruction in Hazmat Disaster ..
  6. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    Barbara McCabe; Fiscal Year: 2007
    ..The target audience for the HDPTP is the same as the HWWTP, but includes, in addition, 60,000 Transport Workers Union employees that operate subways ..
  7. Hazardous Waste Worker Training Program
    JOHN LECONCHE; Fiscal Year: 2007
    ..Hazardous Waste Worker Training Program (HWWTP - $24,169,912) and a Hazmat Disaster Preparedness Training Program (HDPTP - $2,341,200), at a total cost of $26,511,112 over the five years of the program...
  8. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    Carol Rice; Fiscal Year: 2007
    ..provided by applicant) The Midwest Consortium for Hazardous Waste Worker Training will conduct HWWT and HDPTP programs...
  9. WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT
    Patrick Morrison; Fiscal Year: 2007
    ..program areas; Hazardous Waste Worker Training Program (HWWTP) and Hazmat Disaster Preparedness Training Program (HDPTP)...