HCN1

Summary

Gene Symbol: HCN1
Description: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Alias: BCNG-1, BCNG1, EIEE24, HAC-2, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, brain cyclic nucleotide-gated channel 1
Species: human
Products:     HCN1

Top Publications

  1. Tang B, Sander T, Craven K, Hempelmann A, Escayg A. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol Dis. 2008;29:59-70 pubmed
    Hyperpolarization-activated cyclic nucleotide-gated (HCN1-4) channels play an important role in the regulation of neuronal rhythmicity...
  2. Nava C, Dalle C, Rastetter A, Striano P, de Kovel C, Nabbout R, et al. De novo mutations in HCN1 cause early infantile epileptic encephalopathy. Nat Genet. 2014;46:640-5 pubmed publisher
    ..Studies in rat models have shown that the Hcn1 gene has a key role in epilepsy, but clinical evidence implicating HCN1 mutations in human epilepsy is lacking...
  3. Huang Z, Lujan R, Martínez Hernández J, Lewis A, Chetkovich D, Shah M. TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. J Neurosci. 2012;32:14835-48 pubmed publisher
  4. Much B, Wahl Schott C, Zong X, Schneider A, Baumann L, Moosmang S, et al. Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem. 2003;278:43781-6 pubmed
    ..We also identified HCN1/HCN2 heteromers in mouse brain indicating that heteromeric channels exist in vivo...
  5. Han Y, Noam Y, Lewis A, Gallagher J, Wadman W, Baram T, et al. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. J Biol Chem. 2011;286:20823-34 pubmed publisher
    ..Interaction with the last three amino acids of the HCN1 C terminus governed the effect of TRIP8b on channel trafficking, whereas TRIP8b interaction with the HCN1 cyclic ..
  6. Easton D, Pooley K, Dunning A, Pharoah P, Thompson D, Ballinger D, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature. 2007;447:1087-93 pubmed
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach. ..
  7. Alvarez Baron C, Klenchin V, Chanda B. Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family. J Gen Physiol. 2018;150:1203-1213 pubmed publisher
    ..of HCN2 and HCN4 isoforms by shifting the voltage dependence of activation to more depolarized potentials, whereas HCN1 and HCN3 isoforms are practically insensitive to this ligand...
  8. Herrmann S, Schnorr S, Ludwig A. HCN channels--modulators of cardiac and neuronal excitability. Int J Mol Sci. 2015;16:1429-47 pubmed publisher
    ..The four members of this family, HCN1-4, show distinct biophysical properties which are most evident in the kinetics of activation and deactivation, the ..
  9. Zhou C, Liang P, Liu J, Ke B, Wang X, Li F, et al. HCN1 Channels Contribute to the Effects of Amnesia and Hypnosis but not Immobility of Volatile Anesthetics. Anesth Analg. 2015;121:661-666 pubmed publisher
    Hyperpolarization-activated, cyclic nucleotide-gated (HCN) subtype 1 (HCN1) channels have been identified as targets of ketamine to produce hypnosis. Volatile anesthetics also inhibit HCN1 channels...

More Information

Publications76

  1. Ison J, Allen P, Oertel D. Deleting the HCN1 Subunit of Hyperpolarization-Activated Ion Channels in Mice Impairs Acoustic Startle Reflexes, Gap Detection, and Spatial Localization. J Assoc Res Otolaryngol. 2017;18:427-440 pubmed publisher
    ..based on previous in vitro experiments showing that neuronal time constants are raised in brainstem slices when HCN1 channels are blocked or in slices obtained from Hcn1 -/- null mutant mice...
  2. Seo H, Seol M, Lee K. Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. Mol Brain. 2015;8:13 pubmed publisher
    ..Here we examined the developmental expression of the brain-enriched HCN1, HCN2, and HCN4 isoforms of HCN channels in mouse hippocampus from embryonic to postnatal stages...
  3. Bernard M, Dejos C, Bergès T, Régnacq M, Voisin P. Activation of rhodopsin gene transcription in cultured retinal precursors of chicken embryo: role of Ca(2+) signaling and hyperpolarization-activated cation channels. J Neurochem. 2014;129:85-98 pubmed publisher
    ..Cellular localization and developmental expression of HCN1 were compatible with a role in the onset of rhodopsin gene transcription...
  4. Li N, Csepe T, Hansen B, Dobrzynski H, Higgins R, Kilic A, et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circ Arrhythm Electrophysiol. 2015;8:1219-27 pubmed publisher
    ..All 3 HCN isoform proteins were detected in SAN. HCN1 was predominantly distributed in the human SAN with a 125.1±40.2 (n=12) expression ratio of SAN to right atrium...
  5. Klueva J, Lima A, Meis S, Voigt T, Munsch T. Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures. Neurosignals. 2012;20:35-47 pubmed publisher
    ..Immunocytochemistry and Western blot demonstrated that HCN1 and HCN2 were the prevalent isoforms of HCN channels expressed in L-INs and PNs...
  6. Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, et al. Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 2016;25:1165-75 pubmed publisher
    ..Here, we explore the role of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) in this context...
  7. Kashyap M, Yoshimura N, Smith P, Chancellor M, Tyagi P. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Bladder (San Franc). 2015;2: pubmed
    ..Expression of all four genes encoding for HCN channels (HCN1-4) was detected separately in bladder mucosa and detrusor from human and rat bladders...
  8. Nikolaidou T, Cai X, Stephenson R, Yanni J, Lowe T, Atkinson A, et al. Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit. PLoS ONE. 2015;10:e0141452 pubmed publisher
    ..There was downregulation of HCN1 and Cx43 mRNA transcripts across all regions and downregulation of Cav1.3 in the transitional tissue...
  9. Hofmann F, Biel M, Kaupp U. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Pharmacol Rev. 2005;57:455-62 pubmed
  10. Gessele N, Garcia Pino E, Omerbašić D, Park T, Koch U. Structural Changes and Lack of HCN1 Channels in the Binaural Auditory Brainstem of the Naked Mole-Rat (Heterocephalus glaber). PLoS ONE. 2016;11:e0146428 pubmed publisher
    ..Most interestingly, binaural auditory brainstem nuclei lack the membrane-bound hyperpolarization-activated channel HCN1, a voltage-gated ion channel that greatly contributes to the fast integration times in binaural nuclei of the ..
  11. Barthel L, Reetz O, Strauss U. Use Dependent Attenuation of Rat HCN1-Mediated Ih in Intact HEK293 Cells. Cell Physiol Biochem. 2016;38:2079-93 pubmed publisher
    ..and relatively cAMP insensitive subtype of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, HCN1, are limited by cytosolic factors in mammalian cells...
  12. Mengesha H, Tafesse T, Bule M. If Channel as an Emerging Therapeutic Target for Cardiovascular Diseases: A Review of Current Evidence and Controversies. Front Pharmacol. 2017;8:874 pubmed publisher
    ..HCN) subfamily is primarily articulated in the heart and neurons that are encoded by a family of four genes (HCN1-4) and they identify the funny channel. Of these, HCN-4 is the principal protein in the sinoatrial node...
  13. Luo P, Chen C, Lu Y, Fu T, Lu Q, Xu X, et al. Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats. Behav Brain Res. 2016;308:6-13 pubmed publisher
    ..acidic protein (GFAP), synaptophysin (SYP), brain-derived neurotrophic factor (BDNF), parvalbumin (PV) and HCN1 were not distinguishably changed as compared with sham-operated rats...
  14. López González Z, Ayala Aguilera C, Martinez Morales F, Galicia Cruz O, Salvador Hernández C, Pedraza Chaverri J, et al. Immunolocalization of hyperpolarization-activated cationic HCN1 and HCN3 channels in the rat nephron: regulation of HCN3 by potassium diets. Histochem Cell Biol. 2016;145:25-40 pubmed publisher
    Hyperpolarization-activated cationic and cyclic nucleotide-gated channels (HCN) comprise four homologous subunits (HCN1-HCN4). HCN channels are found in excitable and non-excitable tissues in mammals...
  15. Liu Q, Long Z, Dong X, Zhang T, Zhao J, Sun B, et al. Cyclophosphamide-induced HCN1 channel upregulation in interstitial Cajal-like cells leads to bladder hyperactivity in mice. Exp Mol Med. 2017;49:e319 pubmed publisher
    ..Sixty female wild-type C57BL/6J mice and sixty female HCN1-knockout mice were randomly assigned to experimental and control groups, respectively...
  16. He F, Yang Z, Dong X, Fang Z, Liu Q, Hu X, et al. The role of HCN channels in peristaltic dysfunction in human ureteral tuberculosis. Int Urol Nephrol. 2018;50:639-645 pubmed publisher
    ..we showed that the expression of HCN channels was present in normal human ureters, with the expression of HCN4 and HCN1 being the highest; the expression of HCN4 and HCN1 in the control and experimental groups were both statistically ..
  17. Santoro B, Liu D, Yao H, Bartsch D, Kandel E, Siegelbaum S, et al. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998;93:717-29 pubmed
  18. He W, Zhang J, Gan T, Xu G, Tang B. Expression of hyperpolarization-activated cyclic nucleotide-gated channel isoforms in a canine model of atrial fibrillation. Exp Ther Med. 2016;12:433-436 pubmed
    ..However, expression of the HCN1 isoform was not detected...
  19. Sun W, Yang F, Wang Y, Fu H, Yang Y, Li C, et al. Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade. Neuropharmacology. 2017;113:217-230 pubmed publisher
    ..So we examined the roles of HCNs in BV-induced mechanical allodynia. Consistent with the overexpression of HCN1/2 detected by immunofluorescence, HCNs-mediated hyperpolarization activated cation current (Ih) was ..
  20. Santoro B, Grant S, Bartsch D, Kandel E. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997;94:14815-20 pubmed
    ..These findings suggest the existence of a new type of ion channel, which is potentially able to modulate membrane excitability in the brain and could respond to regulation by cyclic nucleotides. ..
  21. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature. 1998;393:587-91 pubmed
    ..We have also identified full-length sequences of two related channels, HAC2 and HAC3, that are specifically expressed in the brain, indicating the existence of a family of hyperpolarization-activated cation channels. ..
  22. Lesso H, Li R. Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype. J Biol Chem. 2003;278:22290-7 pubmed
    If, encoded by the hyperpolarization-activated cyclic nucleotide-modulated channel family (HCN1-4), contributes significantly to neuronal and cardiac pacing...
  23. Kleiderlein J, Nisson P, Jessee J, Li W, Becker K, Derby M, et al. CCG repeats in cDNAs from human brain. Hum Genet. 1998;103:666-73 pubmed
    ..This list of cDNAs should expedite the search for expansion mutations associated with diseases of the central nervous system. ..
  24. Wu S, Ye H, Yang X, Lu Z, Qu Q, Qu J. Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    Epilepsy is a common complex neurological disorder, and some forms are resistant to drug treatment. The HCN1/HCN2 genes encode hyperpolarization-activated cyclic nucleotide-gated channels, which play important roles in the ..
  25. Noam Y, Ehrengruber M, Koh A, Feyen P, Manders E, Abbott G, et al. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014;289:5889-903 pubmed publisher
    ..We focused on the HCN1 channels that conduct Ih, a hyperpolarization-activated current crucial for shaping intrinsic neuronal properties...
  26. Chaplan S, Guo H, Lee D, Luo L, Liu C, Kuei C, et al. Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci. 2003;23:1169-78 pubmed
    ..HCN channels, particularly HCN1, are abundantly expressed in rat primary afferent somata...
  27. Eroli F, Vilotti S, van den Maagdenberg A, Nistri A. Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1. Neuroscience. 2017;351:47-64 pubmed publisher
    ..b>HCN1 and HCN2 were the most abundantly expressed subunits in TG, both in situ and in culture...
  28. Matsumoto Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, et al. Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive. Cell Rep. 2016;16:994-1004 pubmed publisher
    ..Resonance is inhibited by ZD7288 in wild-type mice and impaired in HCN1 KO mice, suggesting that the HCN1 channel is essential for resonance...
  29. Yu S, Na J, Lee Y, Kim K, Park J, Kim H. Forensic application of microRNA-706 as a biomarker for drowning pattern identification. Forensic Sci Int. 2015;255:96-101 pubmed publisher
    ..Among them, miR-706 - targeting HCN1 - was identified as a potent biomarker for the drowning pattern identification...
  30. Hou L, Qi Y, Sun H, Wang G, Li Q, Wang Y, et al. Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:313-321 pubmed publisher
    ..The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, ..
  31. Ding W, You Z, Shen S, Yang J, Lim G, Doheny J, et al. Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain. J Pain. 2018;19:626-634 pubmed publisher
    ..In the Gasserian ganglion, HCN1 and HCN2 are major HCN isoforms...
  32. Mallory C, Hardcastle K, Bant J, Giocomo L. Grid scale drives the scale and long-term stability of place maps. Nat Neurosci. 2018;21:270-282 pubmed publisher
    ..Here we use a targeted viral approach to knock out HCN1 channels selectively in MEC, causing the grid scale to expand while leaving other MEC spatial and velocity signals ..
  33. Chan P, Geng L, Gao Y, Keung W, Li R. AAV-mediated conversion of human pluripotent stem cell-derived pacemaker. Biochem Biophys Res Commun. 2017;494:346-351 pubmed publisher
    ..V) CMs into -PmCMs via recombinant adeno-associated virus serotype 9 (rAAV9)-mediated overexpression of engineered HCN1 channel (HCN1???) whose S3-S4 linker has been strategically deleted by design to promote cardiac pacemaking...
  34. Kuo S, Yang S, You S, Lien H, Lin C, Lin P, et al. Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer. Oncotarget. 2017;8:20925-20938 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) identified by genome-wide association study (GWAS) (MAP3K1, FGFR2, TNRC9, HCN1, and 5p12), and SNPs involved in the metabolism of estrogen (CYP19, COMT, ESR1, and UGT1A1), tamoxifen (CYP2C9, ..
  35. Maroso M, Szabó G, Kim H, Alexander A, Bui A, Lee S, et al. Cannabinoid Control of Learning and Memory through HCN Channels. Neuron. 2016;89:1059-73 pubmed publisher
    ..Strikingly, pharmacological inhibition of Ih or genetic deletion of HCN1 abolishes CB1R-induced deficits in LTP and memory...
  36. Günther A, Baumann A. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes. BMC Cell Biol. 2015;16:18 pubmed publisher
    ..Gene expression profiles of hcn1, hcn2 and hcn4 were acutely affected during HL-1 cell propagation...
  37. Shah M. HCN1 channels: a new therapeutic target for depressive disorders?. Sci Signal. 2012;5:pe44 pubmed publisher
    ..Recent evidence suggests that these channels may also be therapeutic targets for treatment of depressive disorders. ..
  38. Laurin N, Wigg K, Feng Y, Sandor P, Barr C. Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:95-103 pubmed publisher
    ..These genes were GDNF, ITGA1, ISL1, FGF10, HCN1 and SLC1A3...
  39. Laurin N, Lee J, Ickowicz A, Pathare T, Malone M, Tannock R, et al. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:600-5 pubmed
    ..factor (GDNF), the fibroblast growth factor 10 (FGF10), islet-1 (ISL1), the hyperpolarized potassium channel (HCN1) and the integrin alpha 1 (ITGA1)...
  40. Eslamizade M, Saffarzadeh F, Mousavi S, Meftahi G, Hosseinmardi N, Mehdizadeh M, et al. Alterations in CA1 pyramidal neuronal intrinsic excitability mediated by Ih channel currents in a rat model of amyloid beta pathology. Neuroscience. 2015;305:279-92 pubmed publisher
    ..The enhancing effect of Aβ treatment on Ih current was confirmed by showing upregulation of the mRNA of HCN1 channel in the CA1 pyramidal layer of hippocampi...
  41. Han Y, Lyman K, Clutter M, Schiltz G, Ismail Q, Cheng X, et al. Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. J Vis Exp. 2016;: pubmed publisher
    ..focus is on the interaction between the tetratricopeptide repeat (TPR) domains of TRIP8b and the C terminal tail of HCN1. In this protocol, an expanded description of a method for purifying TRIP8b and executing a high throughput screen ..
  42. Fürst O, D Avanzo N. Isoform dependent regulation of human HCN channels by cholesterol. Sci Rep. 2015;5:14270 pubmed publisher
    ..Using electrophysiological and biochemical approaches, we examined the effect of cholesterol modulation on human HCN1, HCN2 and HCN4 isoforms...
  43. Husse B, Franz W. Generation of cardiac pacemaker cells by programming and differentiation. Biochim Biophys Acta. 2016;1863:1948-52 pubmed publisher
    ..cells started with the reprogramming of adult cardiac cells by targeted induction of one pacemaker function like HCN1-4 overexpression and enclosed in an activation of single pacemaker specific transcription factors...
  44. Battefeld A, Bierwirth C, Li Y, Barthel L, Velmans T, Strauss U. I(h) "run-up" in rat neocortical neurons and transiently rat or human HCN1-expressing HEK293 cells. J Neurosci Res. 2010;88:3067-78 pubmed publisher
    ..For a closer investigation of this I(h) increase, we overexpressed the predominant layer 5 rat subunit HCN1 in HEK293 cells. We characterized the resulting I(h) in the cell-attached and whole-cell configurations...
  45. Cao X, Oertel D. The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. J Neurophysiol. 2011;106:630-40 pubmed publisher
    ..in the VCN of mutant mice that lack the hyperpolarization-activated cyclic nucleotide-gated channel ? subunit 1 (HCN1(-/-)) (Nolan et al...
  46. Ding W, You Z, Shen S, Chen L, Zhu S, Mao J. Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats. Neurosci Lett. 2016;631:97-103 pubmed publisher
    ..In the thalamus, immunoreactivity of both HCN1 and HCN2 subunits was increased in both rat models...
  47. Hellmer C, Zhou Y, Fyk Kolodziej B, Hu Z, Ichinose T. Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina. Neuroscience. 2016;315:246-58 pubmed publisher
    ..Furthermore, the former two types showed stronger HCN1 expression than the latter. Our previous observations (Ichinose et al...
  48. Zhang K, Xu T, Yuan Z, Wei Z, Yamaki V, Huang M, et al. Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine. Sci Signal. 2016;9:ra123 pubmed
    ..completely occluded by inhibition or deletion of the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1)...
  49. Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich D, Bähring R, et al. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. FASEB J. 2014;28:2177-90 pubmed publisher
    ..We identified a PY motif (L/PPxY), the characteristic binding motif for Nedd4-2 in the C terminus of the HCN1 subunit, and showed that HCN1 and Nedd4-2 interacted both in vivo (rat hippocampus, neocortex, and cerebellum) and ..
  50. Garden D, Oostland M, Jelitai M, Rinaldi A, Duguid I, Nolan M. Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing. Cell Rep. 2018;22:1722-1733 pubmed publisher
    ..Here, we demonstrate that in vitro, network actions of HCN1 channels enable bidirectional glutamatergic synaptic responses, while local actions of HCN1 channels determine the ..
  51. Parker A, Welch M, Forster L, Tasneem S, Dubhashi J, Baro D. SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current. Front Mol Neurosci. 2016;9:168 pubmed publisher
    ..The SUMOylation site at K669 is also conserved in HCN1 channels...
  52. Resta F, Micheli L, Laurino A, Spinelli V, Mello T, Sartiani L, et al. Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy. Neuropharmacology. 2018;131:403-413 pubmed publisher
    ..Finally, we report the efficacy of the selective HCN1 inhibitor MEL57A in reducing hyperalgesia and allodynia in oxaliplatin-treated rats without cardiac effects...
  53. Temple I, Logantha S, Absi M, Zhang Y, Pervolaraki E, Yanni J, et al. Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. Circ Arrhythm Electrophysiol. 2016;9: pubmed
    ..2/3 and HCN1/2/4 channels)...
  54. Branch S, Chen C, Sharma R, Lechleiter J, Li S, Beckstead M. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. J Neurosci. 2016;36:4026-37 pubmed publisher
    ..Interestingly, expression of ion channel subunits associated with impulse activity (Cav1.2, Cav1.3, HCN1, Nav1.2, and NavB3) was upregulated in older MitoPark mice...
  55. Coll M, Allegue C, Partemi S, Mates J, Del Olmo B, Campuzano O, et al. Genetic investigation of sudden unexpected death in epilepsy cohort by panel target resequencing. Int J Legal Med. 2016;130:331-9 pubmed publisher
    ..Four cases showed rare variants with complete segregation in the SCN1A, FBN1, HCN1, SCN4A, and EFHC1 genes, and one case with a rare variant in KCNQ1 gene showed incomplete pattern of inheritance...
  56. Frigerio F, Flynn C, Han Y, Lyman K, Lugo J, Ravizza T, et al. Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Mol Neurobiol. 2018;55:7500-7511 pubmed publisher
    ..with a significant reduction of the dendritic hyperpolarization-activated cyclic AMP-gated channel type 1 (HCN1) protein level while Kv4.2 channels were unaltered as assessed by western blot...
  57. Liu Y, Feng Y, Zhang T. Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain. J Mol Neurosci. 2015;57:97-105 pubmed publisher
    ..Behavioral tests were performed before surgery (D0), on D07, and on D1, D7, and D14 after PRF or sham treatment. HCN1 and HCN2 expression levels in the DRG were examined by immunohistochemistry and Western blot...
  58. Zhang S, You Z, Wang S, Yang J, Yang L, Sun Y, et al. Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain. Neuropharmacology. 2016;105:420-433 pubmed publisher
    ..The characters of the recorded Ih suggest a major role for HCN1 activity in this process...
  59. Xue L, Li Y, Han X, Yao L, Yuan J, Qin W, et al. Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder. Urology. 2012;80:224.e13-8 pubmed publisher
    ..First, the immunoreactivity of HCN1, HCN2, HCN3, and HCN4 isoforms was detected in the ICCs of lamina propria using immunofluorescence...
  60. Della Santina L, Piano I, Cangiano L, Caputo A, Ludwig A, Cervetto L, et al. Processing of retinal signals in normal and HCN deficient mice. PLoS ONE. 2012;7:e29812 pubmed publisher
    ..mice models and of in vitro (patch-clamp) and in vivo (ERG) recordings of retinal activity we show that HCN1 and HCN2 channels are expressed at distinct retinal sites and serve different functions...
  61. Negrini D, Marcozzi C, Solari E, Bossi E, Cinquetti R, Reguzzoni M, et al. Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics. Am J Physiol Heart Circ Physiol. 2016;311:H892-H903 pubmed publisher
    ..9 ± 2.7% of control. HCN gene expression and immunostaining confirmed the presence of HCN1-4 channel isoforms, likely arranged in different configurations, in LMCs...
  62. Pavlin M, Rossetti G, De Vivo M, Carloni P. Carnosine and Homocarnosine Degradation Mechanisms by the Human Carnosinase Enzyme CN1: Insights from Multiscale Simulations. Biochemistry. 2016;55:2772-84 pubmed publisher
    ..action is severely hampered because of the hydrolysis by carnosinase enzymes, in particular the human carnosinase, hCN1. This belongs to the metallopeptidase M20 family, where a cocatalytic active site is formed by two Zn(2+) ions, ..
  63. Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger M. HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure. PLoS ONE. 2016;11:e0147728 pubmed publisher
    ..In this work, we address the role of hyperpolarization-activated and cyclic nucleotide-gated channels 1 (HCN1) in rod photoreceptors for the enhancement of rod system responsivity under conditions of light exposure...
  64. Hassinen M, Haverinen J, Vornanen M. Small functional If current in sinoatrial pacemaker cells of the brown trout (Salmo trutta fario) heart despite strong expression of HCN channel transcripts. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00227.2017 pubmed publisher
    ..Six HCN transcripts (HCN1, HCN2a, HCN2ba, HCN2bb, HCN3 and HCN4) were expressed in the brown trout heart...
  65. O Donnell A, Coyle D, Puri P. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease. World J Gastroenterol. 2015;21:5635-40 pubmed publisher
    ..We investigated HCN1, HCN2, HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung's disease (HSCR, ..
  66. Bender R, Soleymani S, Brewster A, Nguyen S, Beck H, Mathern G, et al. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003;23:6826-36 pubmed
    ..Therefore, we determined whether HCN isoform expression was modified in hippocampi of individuals with TLE. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi from three ..
  67. Zúñiga R, Gonzalez D, Valenzuela C, Brown N, Zúñiga L. Expression and cellular localization of HCN channels in rat cerebellar granule neurons. Biochem Biophys Res Commun. 2016;478:1429-35 pubmed publisher
    ..In mammals, this family consists of four different subunits (HCN1-4) and their ion channels activity have been proposed to play an essential role in regulating the membrane ..