Gene Symbol: HCG9
Description: HLA complex group 9 (non-protein coding)
Species: human
Products:     HCG9

Top Publications

  1. Yang S, Hong M, Zhao W, Jung Y, Tayebi N, Ye B, et al. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. Inflamm Bowel Dis. 2013;19:954-66 pubmed publisher
    ..Our data suggest that genetic associations for UC tend to overlap more extensively among different ethnic groups than those for Crohn's disease, which shows well-established dependence on ethnicity. ..
  2. Pichon L, Giffon T, Chauvel B, Carn G, Bouric P, El Kahloun A, et al. Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences. Immunogenetics. 1996;43:175-81 pubmed
    ..This allowed for the characterization and localization of two new coding sequences, provisionally named HCG (for hemochromatosis candidate gene) and numbered VIII and IX. ..
  3. Jin Y, Birlea S, Fain P, Gowan K, Riccardi S, Holland P, et al. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med. 2010;362:1686-97 pubmed publisher
  4. Cree B, Rioux J, McCauley J, Gourraud P, Goyette P, McElroy J, et al. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS ONE. 2010;5:e11296 pubmed publisher
    ..A MHC Class I locus contributes to MS susceptibility independently of the HLA-DRB1*15:01 haplotype. ..
  5. Yu X, Li M, Zhang H, Low H, Wei X, Wang J, et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet. 2011;44:178-82 pubmed publisher
    ..003), proteinuria (P = 0.025) and IgA levels (P = 0.047). Our findings show that IgAN is associated with variants near genes involved in innate immunity and inflammation. ..
  6. Pal M, Ebrahimi S, Oh G, Khare T, Zhang A, Kaminsky Z, et al. High Precision DNA Modification Analysis of HCG9 in Major Psychosis. Schizophr Bull. 2016;42:170-7 pubmed publisher
    ..Our findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease. ..
  7. Pichon L, Hampe A, Giffon T, Carn G, LeGall J, David V. A new non-HLA multigene family associated with the PERB11 family within the MHC class I region. Immunogenetics. 1996;44:259-67 pubmed
    ..of one subclone led to the isolation of a potential exon that proved to belong to a new expressed messenger named HCGIX. After Southern blot analysis, the corresponding cDNA clone was found to belong to a new multigene family whose ..
  8. Hampe A, Coriton O, Andrieux N, Carn G, Lepourcelet M, Mottier S, et al. A 356-Kb sequence of the subtelomeric part of the MHC Class I region. DNA Seq. 1999;10:263-99 pubmed
    ..Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes. ..
  9. Fransen E, Bonneux S, Corneveaux J, Schrauwen I, Di Berardino F, White C, et al. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015;23:110-5 pubmed publisher
    ..We estimated that 22% of the variance in our data set can be explained by the collective effect of all genotyped SNPs. A score analysis showed a modest enrichment in causative SNPs among the SNPs with a P-value below 0.01. ..

More Information


  1. Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
    ..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
  2. Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, et al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol Psychiatry. 2012;17:728-40 pubmed publisher
    ..the results of fine mapping DNA methylation differences at the human leukocyte antigen (HLA) complex group 9 gene (HCG9) in bipolar disorder (BPD)...