HCFC1

Summary

Gene Symbol: HCFC1
Description: host cell factor C1
Alias: CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF, host cell factor 1, VP16-accessory protein, protein phosphatase 1, regulatory subunit 89
Species: human
Products:     HCFC1

Top Publications

  1. Dejosez M, Krumenacker J, Zitur L, Passeri M, Chu L, Songyang Z, et al. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell. 2008;133:1162-74 pubmed publisher
    ..We demonstrate that Ronin binds directly to HCF-1, a key transcriptional regulator...
  2. Yu H, Mashtalir N, Daou S, Hammond Martel I, Ross J, Sui G, et al. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol. 2010;30:5071-85 pubmed publisher
    ..BAP1 was recently shown to interact with and deubiquitinate the transcriptional regulator host cell factor 1 (HCF-1)...
  3. Wysocka J, Myers M, Laherty C, Eisenman R, Herr W. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003;17:896-911 pubmed
    The abundant and chromatin-associated protein HCF-1 is a critical player in mammalian cell proliferation as well as herpes simplex virus (HSV) transcription...
  4. Tyagi S, Herr W. E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases. EMBO J. 2009;28:3185-95 pubmed publisher
    ..During the G1-to-S phase transition, E2F1 associates through a short DHQY sequence with the cell-cycle regulator HCF-1 together with the mixed-lineage leukaemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases...
  5. Kristie T, Sharp P. Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). J Biol Chem. 1993;268:6525-34 pubmed
  6. Machida Y, Machida Y, Vashisht A, Wohlschlegel J, Dutta A. The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem. 2009;284:34179-88 pubmed publisher
    ..We show that the interaction with host cell factor-1 (HCF-1), a cell-cycle regulator composed of HCF-1N and HCF-1C, is critical for the BAP1-mediated growth regulation...
  7. Gunther M, Laithier M, Brison O. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. Mol Cell Biochem. 2000;210:131-42 pubmed
    ..Six overlapping cDNA clones corresponded to the Hsc70 protein. Host cell factor (HCF-1) and the KIAA0461 gene (encoding a putative Zn-finger protein of unknown function) were both identified through ..
  8. Lu R, Misra V. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. Nucleic Acids Res. 2000;28:2446-54 pubmed
    Host cell factor (HCF, C1, VCAF or CFF) is a cellular protein that is required for transcription activation of herpes simplex virus (HSV) immediate-early (IE) genes by the virion protein VP16...
  9. Knez J, Piluso D, Bilan P, Capone J. Host cell factor-1 and E2F4 interact via multiple determinants in each protein. Mol Cell Biochem. 2006;288:79-90 pubmed
    Host Cell Factor (HCF-1) is a conserved, essential protein initially identified as a co-regulator for the Herpes Simplex Virus transactivator VP16...

More Information

Publications85

  1. Piluso D, Bilan P, Capone J. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. J Biol Chem. 2002;277:46799-808 pubmed
    Human host cell factor-1 (HCF-1) is essential for cell cycle progression and is required, in conjunction with the herpes simplex virus transactivator VP16, for induction of viral immediate-early gene expression...
  2. Wilson A, Boutros M, Johnson K, Herr W. HCF-1 amino- and carboxy-terminal subunit association through two separate sets of interaction modules: involvement of fibronectin type 3 repeats. Mol Cell Biol. 2000;20:6721-30 pubmed
    When herpes simplex virus infects permissive cells, the viral regulatory protein VP16 forms a specific complex with HCF-1, a preexisting nuclear protein involved in cell proliferation...
  3. Misaghi S, Ottosen S, Izrael Tomasevic A, Arnott D, Lamkanfi M, Lee J, et al. Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol Cell Biol. 2009;29:2181-92 pubmed publisher
    ..We show here that Bap1 interacts with host cell factor 1 (HCF-1), a transcriptional cofactor found in a number of important regulatory complexes...
  4. Liu W, Tanasa B, Tyurina O, Zhou T, Gassmann R, Liu W, et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010;466:508-12 pubmed publisher
    ..based on interaction with H3K4me2/3 and controls G1-S transition in conjunction with E2F1, HCF-1 (also known as HCFC1) and SET1A (also known as SETD1A), at least in part, by removing the repressive H4K20me1 mark from a subset of ..
  5. Vogel J, Kristie T. The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. EMBO J. 2000;19:683-90 pubmed
    ..interactions of the POU-homeodomain protein Oct-1, the viral transactivator alphaTIF and the cellular factor C1 (HCF). In this context, the C1 factor interacts with each protein to assemble the stable enhancer complex...
  6. Wilson A, Freiman R, Goto H, Nishimoto T, Herr W. VP16 targets an amino-terminal domain of HCF involved in cell cycle progression. Mol Cell Biol. 1997;17:6139-46 pubmed
    ..through formation of a multiprotein-DNA complex on viral promoters that includes the preexisting nuclear proteins HCF and Oct-1...
  7. Wilson A, LaMarco K, Peterson M, Herr W. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell. 1993;74:115-25 pubmed
    ..simplex virus (HSV) transactivator protein VP16 associates with an accessory protein termed host cell factor (HCF)...
  8. Wilson A, Peterson M, Herr W. The HCF repeat is an unusual proteolytic cleavage signal. Genes Dev. 1995;9:2445-58 pubmed
    The herpes simplex virus VP16-associated protein HCF is a nuclear host-cell factor that exists as a family of polypeptides encoded by a single gene...
  9. Eletr Z, Wilkinson K. An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys. 2011;60:3-11 pubmed publisher
    ..Recently BAP1 was shown to associate with the transcriptional regulator host cell factor 1 (HCF-1)...
  10. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero D, Kitabayashi I, et al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004;24:5639-49 pubmed
    ..Two other members of the novel MLL complex identified here are host cell factor 1 (HCF-1), a transcriptional coregulator, and the related HCF-2, both of which specifically interact with a ..
  11. Julien E, Herr W. A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Mol Cell. 2004;14:713-25 pubmed
    The abundant chromatin-associated human factor HCF-1 is a heterodimeric complex of HCF-1N and HCF-1C subunits that are essential for two stages of the cell cycle...
  12. Kristie T, Pomerantz J, Twomey T, Parent S, Sharp P. The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. J Biol Chem. 1995;270:4387-94 pubmed
    ..Although the C1 factor appears to be ubiquitously expressed, it is localized to subnuclear structures in specific cell types. ..
  13. Michaud J, Praz V, James Faresse N, Jnbaptiste C, Tyagi S, Schutz F, et al. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. Genome Res. 2013;23:907-16 pubmed publisher
    ..One such intermediary is HCFC1 (also known as HCF-1)...
  14. Mahajan S, Wilson A. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. Mol Cell Biol. 2000;20:919-28 pubmed
    b>Host cell factor 1 (HCF-1) is a nuclear protein required for progression through G(1) phase of the cell cycle and, via its association with VP16, transcriptional activation of the herpes simplex virus immediate-early genes...
  15. Wysocka J, Reilly P, Herr W. Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells. Mol Cell Biol. 2001;21:3820-9 pubmed
    Human HCF-1 is a large, highly conserved, and abundant nuclear protein that plays an important but unknown role in cell proliferation...
  16. Bott M, Brevet M, Taylor B, Shimizu S, Ito T, Wang L, et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. 2011;43:668-72 pubmed publisher
    ..nuclear deubiquitinase is known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCF1 transcriptional co-factor, and we show that BAP1 knockdown in MPM cell lines affects E2F and Polycomb target genes...
  17. Freiman R, Herr W. Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. Genes Dev. 1997;11:3122-7 pubmed
    ..of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose ..
  18. Lu R, Yang P, O Hare P, Misra V. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. Mol Cell Biol. 1997;17:5117-26 pubmed
    The human host cell factor (HCF) is expressed in a variety of adult and fetal tissues, and its gene is conserved in animals as diverse as mammals and insects...
  19. Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J, et al. O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell. 2011;144:376-88 pubmed publisher
    The human epigenetic cell-cycle regulator HCF-1 undergoes an unusual proteolytic maturation process resulting in stably associated HCF-1(N) and HCF-1(C) subunits that regulate different aspects of the cell cycle...
  20. Mangone M, Myers M, Herr W. Role of the HCF-1 basic region in sustaining cell proliferation. PLoS ONE. 2010;5:e9020 pubmed publisher
    The human herpes simplex virus-associated host cell factor 1 (HCF-1) is a conserved human transcriptional co-regulator that links positive and negative histone modifying activities with sequence-specific DNA-binding transcription factors...
  21. Tyagi S, Chabes A, Wysocka J, Herr W. E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. Mol Cell. 2007;27:107-19 pubmed
    ..Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved ..
  22. Narayanan A, Ruyechan W, Kristie T. The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection. Proc Natl Acad Sci U S A. 2007;104:10835-40 pubmed
    ..simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory circuits...
  23. Smith E, Cayrou C, Huang R, Lane W, Cote J, Lucchesi J. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol. 2005;25:9175-88 pubmed
    ..We also find that hMOF is a component of additional complexes, forming associations with host cell factor 1 and a protein distantly related to MSL1 (hMSL1v1)...
  24. Julien E, Herr W. Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. EMBO J. 2003;22:2360-9 pubmed
    b>HCF-1 is a highly conserved and abundant chromatin-associated host cell factor required for transcriptional activation of herpes simplex virus immediate-early genes by the virion protein VP16...
  25. Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, et al. Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med. 2018;7:1546-1559 pubmed publisher
    ..In this study, we analyzed the effect of CFF-1 (alcohol extract from an anticancer compound Chinese medicine) on prostate cancer (PCa) cell lines and studied in ..
  26. Levine Z, Walker S. The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?. Annu Rev Biochem. 2016;85:631-57 pubmed publisher
    ..nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator host cell factor 1 (HCF-1) and serves as an integral member of several protein complexes, many of them linked to gene ..
  27. Lim J, Lee B, Kim J, Han Y, Chung J, Kim M, et al. Evaluation of extraction methods for methylated cell-free fetal DNA from maternal plasma. J Assist Reprod Genet. 2018;35:637-641 pubmed publisher
    ..fetal placenta-specific epigenetic regions (FSERs) have been identified for quantification of cell-free fetal DNA (cff-DNA) for non-invasive prenatal testing (NIPT)...
  28. Misra V, Rapin N, Akhova O, Bainbridge M, Korchinski P. Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. J Biol Chem. 2005;280:15257-66 pubmed
    Host cell factor (HCF) was initially discovered as a cellular co-factor required for the activation of herpes simplex virus immediate early gene expression by the virion associated transactivator VP16...
  29. Mine I, Taguchi M, Sakurai Y, Takeuchi M. Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. BMC Ophthalmol. 2017;17:128 pubmed publisher
    ..The critical flicker frequency (CFF) was 23 Hz in the right eye and 27 Hz in the left eye...
  30. Spinella J, Cassart P, Garnier N, Rousseau P, Drullion C, Richer C, et al. A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells. BMC Cancer. 2015;15:621 pubmed publisher
    ..D835Y, NRAS p.G13D, BRAF p.G466A). The remaining three patient-specific mutations (ACD p.G223V, DOT1L p.V114F, HCFC1 p.Y103H) were novel mutations previously undescribed in public cancer databases...
  31. Wella Hewage C, Alankarage Hewa G, Pezzaniti D. Can water sensitive urban design systems help to preserve natural channel-forming flow regimes in an urbanised catchment?. Water Sci Technol. 2016;73:78-87 pubmed publisher
    ..investigated the ability of infiltration-based WSUD systems to replicate the predevelopment channel-forming flow (CFF) regime in urban catchments...
  32. van der Graaf van Bloois L, Duim B, Miller W, Forbes K, Wagenaar J, Zomer A. Whole genome sequence analysis indicates recent diversification of mammal-associated Campylobacter fetus and implicates a genetic factor associated with H2S production. BMC Genomics. 2016;17:713 pubmed publisher
    ..C. fetus has been divided into three subspecies: C. fetus subsp. fetus (Cff), C. fetus subsp. venerealis (Cfv) and C. fetus subsp. testudinum (Cft)...
  33. Zhou P, Wang Z, Yuan X, Zhou C, Liu L, Wan X, et al. Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem. 2013;288:17532-43 pubmed publisher
    ..study, we found that the MLL5 protein can associate with the cell cycle regulator "host cell factor" (HCF-1)...
  34. Li X, Wang S, Li Y, Deng C, Steiner L, Xiao H, et al. Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood. 2011;118:1386-94 pubmed publisher
    ..Therefore, our data reveal a synergistic role of hSET1 and NURF in regulating the USF-bound barrier insulator to prevent erythroid genes from encroachment of heterochromatin. ..
  35. Lundberg S, Tu W, Raught B, Penn L, Hoffman M, Lee S. ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data. Genome Biol. 2016;17:82 pubmed publisher
    ..We experimentally validated one of the previously unreported interactions, MYC-HCFC1. An interactive visualization tool is available at http://chromnet.cs.washington.edu.
  36. Kwon D, Tak S, Lee J, Kim M, Lee Y, Han D, et al. Desorption of micropollutant from spent carbon filters used for water purifier. Environ Sci Pollut Res Int. 2017;24:17606-17615 pubmed publisher
    ..A total of 11 micropollutants (caffeine (CFF), acetaminophen (ACT), sulfamethazine (SMA), sulfamethoxazole (SMZ), metoprolol (MTP), carbamazepine (CBM), ..
  37. Hanson N, Short L, Flood L, Cherup N, Miller M. Cortical neural arousal is differentially affected by type of physical exercise performed. Exp Brain Res. 2018;236:1643-1649 pubmed publisher
    Critical flicker frequency (CFF) threshold is a visual discrimination task designed to assess cortical neural arousal, where higher values are associated with increased information processing and improved cognitive function...
  38. Watkins D, Rosenblatt D. Lessons in biology from patients with inherited disorders of vitamin B12 and folate metabolism. Biochimie. 2016;126:3-5 pubmed publisher
    ..Mutations in the HCFC1 gene on the X chromosome have been identified in several male patients that had received a diagnosis of cblC on ..
  39. Ampuero J, Simón M, Montoliú C, Jover R, Serra M, Córdoba J, et al. Minimal hepatic encephalopathy and critical flicker frequency are associated with survival of patients with cirrhosis. Gastroenterology. 2015;149:1483-9 pubmed publisher
    ..All patients were administered the critical flicker frequency (CFF) test and psychometric hepatic encephalopathy scores were used to detect MHE...
  40. Zhou X, Yang A, Huang Z, Yin G, Pu X, Jin J. Enhancement of neurite adhesion, alignment and elongation on conductive polypyrrole-poly(lactide acid) fibers with cell-derived extracellular matrix. Colloids Surf B Biointerfaces. 2017;149:217-225 pubmed publisher
    Extracellular matrix (ECM) can promote peripheral nerve repair. In this study, a conductive fiber-film (CFF) with core-sheath structure and conductivity of ?10Scm-1 was prepared by electrospinning of aligned poly(l-lactide ..
  41. Kötzler M, Withers S. Proteolytic Cleavage Driven by Glycosylation. J Biol Chem. 2016;291:429-34 pubmed publisher
    Proteolytic processing of human host cell factor 1 (HCF-1) to its mature form was recently shown, unexpectedly, to occur in a UDP-GlcNAc-dependent fashion within the transferase active site of O-GlcNAc-transferase (OGT) (Lazarus, M. B...
  42. Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471 pubmed publisher
    ..BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination. KLF5 is in the BAP1/HCF-1 complex, and this newly identified complex promotes cell cycle progression partially by inhibiting p27 gene ..
  43. Weinstein S, Cruz R, Isaia A, Peters A, West A. Child- and Family-Focused Cognitive Behavioral Therapy for Pediatric Bipolar Disorder: Applications for Suicide Prevention. Suicide Life Threat Behav. 2017;: pubmed publisher
    ..SI outcomes in a randomized clinical trial comparing Child- and Family-Focused Cognitive Behavioral Therapy (CFF-CBT) for PBD versus psychotherapy treatment-as-usual (TAU)...
  44. Bhuiyan T, Waridel P, Kapuria V, Zoete V, Herr W. Distinct OGT-Binding Sites Promote HCF-1 Cleavage. PLoS ONE. 2015;10:e0136636 pubmed publisher
    Human HCF-1 (also referred to as HCFC-1) is a transcriptional co-regulator that undergoes a complex maturation process involving extensive O-GlcNAcylation and site-specific proteolysis...
  45. Kim J, Lee J. Influence of Interleaved Films on the Mechanical Properties of Carbon Fiber Fabric/Polypropylene Thermoplastic Composites. Materials (Basel). 2016;9: pubmed publisher
    ..Carbon fiber fabric (CFF) and polypropylene (PP) were used to manufacture the thermoplastic prepregs...
  46. Quintana A, Yu H, Brebner A, Pupavac M, Geiger E, Watson A, et al. Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Hum Mol Genet. 2017;26:2838-2849 pubmed publisher
    ..Mutations in HCFC1, a transcriptional co-regulator which interacts with multiple transcription factors, have been associated with ..
  47. Schulz C, Schütte K, Reisener N, Voss J, Malfertheiner P. Prevalence of Helicobacter pylori Infection in Patients with Minimal Hepatic Encephalopathy. J Gastrointestin Liver Dis. 2016;25:191-5 pubmed publisher
    ..Out of 84 LC patients (83% male), 29% presented with MHE as assessed by critical flicker frequency analysis (CFF). The prevalence of H. pylori infection in the cohort was 21%; 22% of H...
  48. Mazars R, Gonzalez de Peredo A, Cayrol C, Lavigne A, Vogel J, Ortega N, et al. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. J Biol Chem. 2010;285:13364-71 pubmed publisher
    ..Proteomic analyses identified HCF-1, a potent transcriptional coactivator and cell cycle regulator, and O-GlcNAc transferase (OGT), the enzyme that ..
  49. Trung N, Kremmer E, Mittler G. Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif. BMC Genomics. 2016;17:693 pubmed publisher
    ..Our data strongly suggest that THAP11 and Ikaros interact directly, while NFKB1 (NF-kappa B p50) and HCF-1 are binding indirectly to M4-promoters in vitro and in living cells...
  50. Ge H, Si Y, Roeder R. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J. 1998;17:6723-9 pubmed
    ..These results suggest that p52 is a general transcriptional coactivator that mediates functional interactions between upstream sequence-specific activators and the general transcription apparatus, possibly through a novel mechanism. ..
  51. Lee J, Skalnik D. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol Cell Biol. 2008;28:609-18 pubmed
    ..These results suggest a model for how the mammalian RNAP II machinery is linked with histone H3-Lys4 histone methyltransferase complexes at transcriptionally active genes. ..
  52. Ajuh P, Chusainow J, Ryder U, Lamond A. A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing. EMBO J. 2002;21:6590-602 pubmed
    Human factor C1 (HCF-1) is needed for the expression of herpes simplex virus 1 (HSV-1) immediate-early genes in infected mammalian cells...
  53. Klemm R, Goodrich J, Zhou S, Tjian R. Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. Proc Natl Acad Sci U S A. 1995;92:5788-92 pubmed
    ..These findings indicate that specific activator-coactivator interactions have been conserved between human and Drosophila and provide additional support for the function of these interactions in mediating transcriptional activation. ..
  54. Ruan H, Han X, Li M, Singh J, Qian K, Azarhoush S, et al. O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1? stability. Cell Metab. 2012;16:226-37 pubmed publisher
    ..identified a broad variety of proteins associated with O-GlcNAc transferase (OGT), among which host cell factor C1 (HCF-1) is highly abundant...
  55. Thomas L, Foshage A, Weissmiller A, Popay T, Grieb B, Qualls S, et al. Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif. Oncogene. 2016;35:3613-8 pubmed publisher
    ..that MbIV is required for the association of MYC with the abundant transcriptional coregulator host cell factor-1 (HCF-1)...
  56. Wu M, Wang P, Lee J, Martin Brown S, Florens L, Washburn M, et al. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol. 2008;28:7337-44 pubmed publisher
    ..Given our in vivo and in vitro observations, it appears that the human Set1 complex plays a more widespread role in H3K4 trimethylation than do the MLL complexes in mammalian cells. ..
  57. Dheekollu J, Wiedmer A, Sentana Lledo D, Cassel J, Messick T, Lieberman P. HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr Virus. J Virol. 2016;90:5353-5367 pubmed publisher
    ..b>Host cell factor 1 (HCF1), a component of the mixed-lineage leukemia (MLL) histone methyltransferase complex, and transcription ..
  58. Hebert L, Bellanger D, Guillas C, Campagne A, Dingli F, Loew D, et al. Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function. Oncotarget. 2017;8:72513-72527 pubmed publisher
    ..This complex also mediates the poly-deubiquitination of HCFC1, OGT and PCG1-?, preventing them from proteasomal degradation...
  59. Mulley J, Kerr B, Stevenson R, Lubs H. Nomenclature guidelines for X-linked mental retardation. Am J Med Genet. 1992;43:383-91 pubmed
    ..Non-specific mental retardations (MRX) are given unique symbols for each family (MRX1, MRX2, MRX3 ...)...
  60. Saint S, Hammond B, O Brien K, Frick J. Developmental trends in infant temporal processing speed. Vision Res. 2017;138:71-77 pubmed publisher
    ..Visual temporal processing speed (measured via critical flicker fusion [CFF] thresholds) represents the maximum speed at which the visual system can detect changes...
  61. Jolly L, Nguyen L, Domingo D, Sun Y, Barry S, Hancarova M, et al. HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain. Hum Mol Genet. 2015;24:3335-47 pubmed publisher
    Both gain- and loss-of-function mutations have recently implicated HCFC1 in neurodevelopmental disorders...
  62. Parker J, Yin H, Vinckevicius A, Chakravarti D. Host cell factor-1 recruitment to E2F-bound and cell-cycle-control genes is mediated by THAP11 and ZNF143. Cell Rep. 2014;9:967-82 pubmed publisher
    Host cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle progression and cell proliferation...
  63. Garapaty S, Xu C, Trojer P, Mahajan M, Neubert T, Samuels H. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem. 2009;284:7542-52 pubmed publisher
    ..components revealed factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1, DBC-1, and EMSY...
  64. Ma R, Wu Q, Si T, Chang S, Xu R. Oxygen and Indocyanine Green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells. Ultrason Sonochem. 2017;39:197-207 pubmed publisher
    ..and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT)...
  65. Ji Z, Mohammed H, Webber A, Ridsdale J, Han N, Carroll J, et al. The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex. Nucleic Acids Res. 2014;42:6232-42 pubmed publisher
    ..Our results therefore provide an important link between BAP1 and the transcription factor FOXK2 and demonstrate how BAP1 can be recruited to specific regulatory loci. ..
  66. Zhou H, Wong C, Chen J, Qiang B, Yuan J, Jin D. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J Biol Chem. 2001;276:28933-8 pubmed
    b>Host cell factor 1 (HCF-1) is a cellular transcriptional coactivator which coordinates the assembly of enhancer complex through direct interactions with viral and cellular trans-activators such as VP16, Oct-1, LZIP, and GA-binding protein...
  67. Yu H, Sloan J, Scharer G, Brebner A, Quintana A, Achilly N, et al. An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1. Am J Hum Genet. 2013;93:506-14 pubmed publisher
    ..A missense mutation in a global transcriptional coregulator, HCFC1, was identified in the index case...
  68. Lu R, Yang P, Padmakumar S, Misra V. The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. J Virol. 1998;72:6291-7 pubmed
    ..gene promoters with two cellular proteins: the POU domain protein Oct-1 and host cell factor (HCF; also called C1, VCAF, and CFF)...
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