HCCS

Summary

Gene Symbol: HCCS
Description: holocytochrome c synthase
Alias: CCHL, LSDMCA1, MCOPS7, MLS, cytochrome c-type heme lyase, cytochrome c heme-lyase, holocytochrome c-type synthase, microphthalamia with linear skin defects
Species: human
Products:     HCCS

Top Publications

  1. Wapenaar M, Bassi M, Schaefer L, Grillo A, Ferrero G, Chinault A, et al. The genes for X-linked ocular albinism (OA1) and microphthalmia with linear skin defects (MLS): cloning and characterization of the critical regions. Hum Mol Genet. 1993;2:947-52 pubmed
    ..map the genes for two X-linked disorders, ocular albinism type 1 (OA1) and microphthalmia with linear skin defects (MLS)...
  2. Wimplinger I, Morleo M, Rosenberger G, Iaconis D, Orth U, Meinecke P, et al. Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome. Am J Hum Genet. 2006;79:878-89 pubmed
    ..R217C) and a nonsense mutation (p.R197X)--in the HCCS gene...
  3. Wimplinger I, Shaw G, Kutsche K. HCCS loss-of-function missense mutation in a female with bilateral microphthalmia and sclerocornea: a novel gene for severe ocular malformations?. Mol Vis. 2007;13:1475-82 pubmed
    To analyze if mutations in HCCS, encoding the mitochondrial holocytochrome c-type synthase, are associated with phenotypes other than the microphthalmia with linear skin defects (MLS) syndrome, including severe eye malformations such as ..
  4. Song C, Li Y, Mou H, Moore J, Park A, Pomyen Y, et al. Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Gastroenterology. 2017;152:1161-1173.e1 pubmed publisher
    ..Knockdown of HMGA2 delayed formation of xenograft tumors from cells that expressed oncogenic RAS. In human HCCs, low levels of NF1 messenger RNA or high levels of HMGA2 messenger RNA were associated with shorter patient ..
  5. Su I, Wang L, Hsieh W, Wu H, Teng C, Tsai H, et al. The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis. J Biomed Sci. 2014;21:98 pubmed publisher
    ..The pre-S2 deletion mutants and type II GGHs therefore represent novel biomarkers of HBV-related HCCs. A versatile DNA array chip has been developed to detect pre-S2 mutants in serum...
  6. Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, et al. Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1. Gastroenterology. 2017;153:799-811.e33 pubmed publisher
    ..Kaplan-Meier survival analysis showed that patients with HCCs with lower levels of RCAN1...
  7. Weiler S, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology. 2017;152:2037-2051.e22 pubmed publisher
    ..We performed immunohistochemical analyses on tissue microarrays of 105 HCCs and 7 nontumor liver tissues...
  8. Aziz K, Limzerwala J, Sturmlechner I, Hurley E, Zhang C, Jeganathan K, et al. Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice. Gastroenterology. 2019;: pubmed publisher
    ..which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus ..
  9. Engelholm L, Riaz A, Serra D, Dagnæs Hansen F, Johansen J, Santoni Rugiu E, et al. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma. Gastroenterology. 2017;153:1662-1673.e10 pubmed publisher
    ..The tumors contained the Dnajb1-Prkaca gene fusion and had histologic and cytologic features of human FL-HCCs: large polygonal cells with granular, eosinophilic, and mitochondria-rich cytoplasm, prominent nucleoli, and ..

More Information

Publications146 found, 100 shown here

  1. Kodama T, Bard Chapeau E, Newberg J, Kodama M, Rangel R, Yoshihara K, et al. Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma. Gastroenterology. 2016;151:324-337.e12 pubmed publisher
    ..sequencing technologies have identified thousands of infrequently mutated genes in hepatocellular carcinomas (HCCs)...
  2. Zhang Y, Guo L, Chen X, Wang G, Ni R, Wang M, et al. The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells. Mol Med Rep. 2015;11:797-804 pubmed publisher
    ..ligand in cells, therefore indicating that it may be involved with other pathways that regulate apoptosis in HCCs. In conclusion, the results of the present study indicated that DR3 may be a promising therapeutic target molecule ..
  3. Yamada H, Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, et al. Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis. 2015;36:429-40 pubmed publisher
    ..Treatment with the carcinogen azoxymethane caused Sgo1(-/+) ME-CIN model mice to develop HCCs within 6 months, whereas control mice developed no HCC (P < 0.003)...
  4. Tebbi A, Levillayer F, Jouvion G, Fiette L, Soubigou G, Varet H, et al. Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress. Carcinogenesis. 2016;37:39-48 pubmed publisher
    ..Microarray analysis in Mdr2-/- MEFs and cap analysis of gene expression in Mdr2 (-/-) HCCs revealed extensively deregulated genes involved in oxidation reduction, fatty acid metabolism and lipid ..
  5. Zhang H, Xing Z, Mani S, Bancel B, Durantel D, Zoulim F, et al. RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. Hepatology. 2016;64:1033-48 pubmed publisher
    ..In HBV replicating cells, including virus-associated HCCs, suppressor of zeste 12 homolog (SUZ12), a core subunit of Polycomb repressive complex2 (PRC2), undergoes ..
  6. Lin X, Hu L, Gu J, Wang R, Li L, Tang J, et al. Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. Gastroenterology. 2017;152:1187-1202 pubmed publisher
    ..We found levels of CHKA to be increased in human HCCs compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness and reduced ..
  7. Park E, Kim S, Lee J, Kim Y, Lee D, Cho E, et al. The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma. Cancer Med. 2017;6:749-760 pubmed publisher
    ..8%, based on 2.1-fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion...
  8. Hosui A, Klover P, Tatsumi T, Uemura A, Nagano H, Doki Y, et al. Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression. Int J Cancer. 2012;131:2774-84 pubmed publisher
    ..Recently, interferon (IFN) α has been reported to be effective for prevention of hepatocellular carcinomas (HCCs) recurrence, but the detailed mechanisms remain elusive...
  9. Wang Y, Du L, Liang X, Meng P, Bi L, Wang Y, et al. Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate-Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice. Hepatology. 2018;: pubmed publisher
    ..glutamine catabolism and adenosine triphosphate (ATP) homeostasis, but its character in hepatocellular carcinomas (HCCs) remains obscure. In this study, we observed low expression of SIRT4 in both HCC cell lines and HCCs from patients...
  10. Bannasch P, Ribback S, Su Q, Mayer D. Clear cell hepatocellular carcinoma: origin, metabolic traits and fate of glycogenotic clear and ground glass cells. Hepatobiliary Pancreat Dis Int. 2017;16:570-594 pubmed publisher
    ..hepatocytes with excessive glycogen and/or fat and shares histology, clinical features and etiology with common HCCs. Studies in animal models of chemical, hormonal and viral hepatocarcinogenesis and observations in patients with ..
  11. Pok S, Barn V, Wong H, Blackburn A, Board P, Farrell G, et al. Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis. J Gastroenterol Hepatol. 2016;31:1210-9 pubmed publisher
    ..We studied dysplastic liver and HCCs in intact and castrated diethylnitrosamine-injected C57BL/6J male and female mice, with or without hormonal ..
  12. Teng C, Hsieh W, Wu H, Lin Y, Tsai H, Huang W, et al. Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade. PLoS ONE. 2015;10:e0122373 pubmed publisher
    ..The pre-S2 mutant transgenic HCCs showed glycogen depletion...
  13. Fan H, Zhang H, Pascuzzi P, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016;35:715-26 pubmed publisher
    ..EpCAM upregulation occurs in HBV-mediated HCCs and hepatic cancer stem cells, by a mechanism not understood...
  14. Zhou G, Sprengers D, Boor P, Doukas M, Schutz H, Mancham S, et al. Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas. Gastroenterology. 2017;153:1107-1119.e10 pubmed publisher
    ..We analyzed HCC samples from patients to determine if these inhibitory pathways prevent T-cell responses in HCCs and to find ways to restore their antitumor functions...
  15. Feng H, Yu Z, Tian Y, Lee Y, Li M, Go M, et al. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. J Hepatol. 2015;62:1100-11 pubmed publisher
    ..More importantly, the hyperactivation of the CCRK-EZH2 circuitry in human HCCs correlated with tumor recurrence and poor survival...
  16. Lu G, Ang Y, Zhou J, Tamilarasi J, Yan B, Lim Y, et al. CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. Hepatology. 2015;61:965-78 pubmed publisher
    ..Expression of C/EBPα protein was increased in the majority of HCCs examined (191 pairs) compared with adjacent nontumor liver tissues in HCC tissue microarrays...
  17. Takeishi K, Maeda T, Shirabe K, Tsujita E, Yamashita Y, Harimoto N, et al. Clinicopathologic Features and Outcomes of Non-B, Non-C Hepatocellular Carcinoma After Hepatectomy. Ann Surg Oncol. 2015;22 Suppl 3:S1116-24 pubmed publisher
    ..NBNC-HCC patients had better liver function but more advanced and larger HCCs and a high incidence of intrahepatic metastasis compared to HV-HCC patients...
  18. Jiang L, Kwong D, Liu M, Yuan Y, Li Y, Fu L, et al. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. Carcinogenesis. 2015;36:1111-20 pubmed publisher
    ..In this study, down-regulation of HBP21 was frequently detected in primary HCCs (87/120, 72.5%), which was significantly associated with advanced clinical stage (P = 0...
  19. Prepeluh N, Korpar B, Zagorac A, Zagradisnik B, Golub A, Kokalj Vokac N. A mosaic form of microphthalmia with linear skin defects. BMC Pediatr. 2018;18:254 pubmed publisher
    ..In our case, we describe a newborn with mosaic deletion encompassing HCCS gene resulting in unilateral microphthalmia and facial skin lesions...
  20. Zhang B, Zhang Y, Zou X, Chan A, Zhang R, Lee T, et al. The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma. J Pathol. 2017;243:418-430 pubmed publisher
    ..We showed that CTCF is frequently upregulated in a subset of primary hepatocellular carcinomas (HCCs) as compared with non-tumoural liver...
  21. Govaere O, Petz M, Wouters J, Vandewynckel Y, Scott E, Topal B, et al. The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. Oncogene. 2017;36:6605-6616 pubmed publisher
    Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and ..
  22. Dang S, Zhou J, Chen Y, Chen P, Ji M, Shi B, et al. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. Oncogene. 2019;: pubmed publisher
    ..In addition, our data showed that ZNF382 was frequently downregulated by promoter methylation in HBV-related HCCs relative to HBV-infected liver cirrhosis tissues, and decreased expression of ZNF382 was strongly correlated with ..
  23. Frau C, Loi R, Petrelli A, Perra A, Menegon S, Kowalik M, et al. Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats. Hepatology. 2015;61:249-59 pubmed publisher
    ..of TRβ1 and TRα1 and their target genes in early preneoplastic lesions and hepatocellular carcinoma (HCCs), suggesting that a hypothyroid status favors the onset and progression of preneoplastic lesions to HCC...
  24. Chan C, Chen C, Lee Y, You L. DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss. Mol Cancer Res. 2019;17:555-566 pubmed publisher
    ..accumulation of unrepaired DNA damage, replication stress, and eventually, spontaneous liver tumors and DEN-induced HCCs in Alb-Cre/+;Ddx3xflox/flox mice...
  25. Tsunedomi R, Iizuka N, Yoshimura K, Iida M, Tsutsui M, Hashimoto N, et al. ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma. Int J Oncol. 2013;42:1551-9 pubmed publisher
    ..We confirmed that ABCB6 mRNA levels were significantly higher in hepatitis C virus (HCV)-related HCCs with early IHR compared to HCV-related HCCs without early IHR (2.5-fold, P=0...
  26. Hsieh Y, Chang Y, Su I, Yen C, Liu Y, Liu R, et al. Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis. J Pathol. 2015;236:337-47 pubmed publisher
    ..marker for the loss of genome integrity in chronic HBV carriers and explain the complex chromosome changes in HCCs. Mouse array CGH raw data: GEO Accession No. GSE61378 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61378).
  27. Liu T, Chen J, Xiao S, Lei X. H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma. Tumour Biol. 2016;37:6419-28 pubmed publisher
    ..Our findings showed that the expression level of HLX1 was significantly reduced in HCCs compared to ANLTs...
  28. Zhao N, Sun B, Zhao X, Wang Y, Sun H, Dong X, et al. Changes in microRNAs associated with Twist-1 and Bcl-2 overexpression identify signaling pathways. Exp Mol Pathol. 2015;99:524-32 pubmed publisher
    ..of Twist-1 and Bcl-2, we performed a comprehensive comparative bioinformatics analysis using microarrays on HCCs that overexpressed Twist-1 and Bcl-2...
  29. Sonohara F, Inokawa Y, Hayashi M, Yamada S, Sugimoto H, Fujii T, et al. Prognostic Value of Long Non-Coding RNA HULC and MALAT1 Following the Curative Resection of Hepatocellular Carcinoma. Sci Rep. 2017;7:16142 pubmed publisher
    ..In this study, the expressions of lncRNAs were investigated in resected 158 hepatocellular carcinomas (HCCs) to evaluate the effects of their expression levels on prognosis...
  30. Agosti P, Sabba C, Mazzocca A. Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment. Biochim Biophys Acta Mol Basis Dis. 2018;1864:607-617 pubmed publisher
    ..This may be explained by the increasing number of HCCs developing on steatosis (NAFLD) and steatohepatitis (NASH), related to metabolic risk factors (i.e...
  31. Shibata S, Takamatsu S, Yamamoto K, Mizuhata M, Bou S, Sato Y, et al. Proton Beam Therapy without Fiducial Markers Using Four-Dimensional CT Planning for Large Hepatocellular Carcinomas. Cancers (Basel). 2018;10: pubmed publisher
    ..Respiratory-gated PBT with 4D-CT planning without fiducial markers is a less invasive and equally effective treatment for large HCCs as PBT with fiducial markers.
  32. Zhang X, Zhang X, Wang T, Wang L, Tan Z, Wei W, et al. MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. Cancer Lett. 2018;426:98-108 pubmed publisher
    The transcription factor c-Myc is a key driver for hepatocellular carcinomas (HCCs), while the polycombrepressive complex 2 (PRC2) subunit EZH2 is an essential biomarker of HCC...
  33. Cortis K, Liotta R, Miraglia R, Caruso S, Tuzzolino F, Luca A. Incorporating the hepatobiliary phase of gadobenate dimeglumine-enhanced MRI in the diagnosis of hepatocellular carcinoma: increasing the sensitivity without compromising specificity. Acta Radiol. 2016;57:923-31 pubmed publisher
    ..of the hepatobiliary phase on Gadobenate dimeglumine (Gd-BOPTA) magnetic resonance imaging (MRI) in characterizing HCCs lacking the typical arterial enhancement and venous washout...
  34. Jin J, Jung H, Lee K, Yi N, Suh K, Jang J, et al. Nuclear Expression of Hepatitis B Virus X Protein Is Associated with Recurrence of Early-Stage Hepatocellular Carcinomas: Role of Viral Protein in Tumor Recurrence. J Pathol Transl Med. 2016;50:181-9 pubmed publisher
    ..HBV surface antigen (HBsAg), HBV core antigen (HBcAg), and HBV X protein (HBx) were assessed in 328 HBV-associated HCCs and in 155 matched nontumorous tissues by immunohistochemistry staining...
  35. Sia D, Jiao Y, Martinez Quetglas I, Kuchuk O, Villacorta Martin C, Castro de Moura M, et al. Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. Gastroenterology. 2017;153:812-826 pubmed publisher
    ..We aimed to characterize molecular features of immune cells that infiltrate hepatocellular carcinomas (HCCs) to determine whether these types of agents might be effective against liver tumors...
  36. Pezzuto F, Izzo F, Buonaguro L, Annunziata C, Tatangelo F, Botti G, et al. Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma. Oncotarget. 2016;7:54253-54262 pubmed publisher
    ..analyzed TERT promoter and CTNNB1 gene mutations in 122 cases of hepatitis B (HBV) and hepatitis C (HCV) related HCCs, in 7 cases of cholangiocarcinoma (CC) and hepatocholangiocarcinoma (HCC-CC) as well as in autologous cirrhotic ..
  37. Watanabe M, Shiozawa K, Takahashi M, Wakui N, Otsuka Y, Kaneko H, et al. Parametric imaging using contrast-enhanced ultrasound with Sonazoid for hepatocellular carcinoma. J Med Ultrason (2001). 2010;37:81-6 pubmed publisher
    ..Two patients with HCCs underwent CE-US with Sonazoid before surgical resection...
  38. Li W, Li M, Liao D, Lu X, Gu X, Zhang Q, et al. Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma. Oncotarget. 2016;7:55110-55127 pubmed publisher
    ..In this report, we investigated frequency of this natural HBx mutant in HCCs and its functional significance...
  39. Zhang W, Jiang L, Yan L, Yang J, Li B, Wen T, et al. Radiofrequency ablation for HCC patients with multifocal tumours meeting the Milan criteria: A single-centre experience. Dig Liver Dis. 2016;48:1485-1491 pubmed publisher
    ..been recommended as a curative treatment for patients with single early-stage unifocal hepatocellular carcinomas (HCCs) for years; however, the effect of this treatment on multifocal tumours has remained uncertain...
  40. Fleming B, Ho M. Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer. Toxins (Basel). 2016;8: pubmed publisher
    ..This immunotoxin was found to be highly effective in the treatment of human HCCs in mouse xenograft models...
  41. Paul S, Dhamija E, Gamanagatti S, Sreenivas V, Yadav D, Jain S, et al. Evaluation of tumor response to intra-arterial chemoembolization of hepatocellular carcinoma: Comparison of contrast-enhanced ultrasound with multiphase computed tomography. Diagn Interv Imaging. 2017;98:253-260 pubmed publisher
    ..Fifty patients (41 men, 9 women; mean age, 53 years±12.5 [SD]) with a total of 70 HCCs (mean size, 5cm±3 [SD]) were evaluated. Post-TACE therapeutic assessment of HCC was done at 4 weeks...
  42. Kim M, Kang T, Jeong W, Kim Y, Kim S, Kim J, et al. Gadoxetic acid-enhanced magnetic resonance imaging characteristics of hepatocellular carcinoma occurring in liver transplants. Eur Radiol. 2017;27:3117-3127 pubmed publisher
    ..The enhancement pattern of gadoxetic acid-enhanced MR images of 25 patients with recurrent HCCs (LT group) and 25 surgically confirmed HCC patients in the non-transplanted (control) group were compared...
  43. Huang A, Zhao X, Yang X, Li F, Zhou X, Wu K, et al. Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma. J Hepatol. 2017;67:293-301 pubmed publisher
    ..This study aimed to identify the most efficient strategy to identify all the mutations within heterogeneous HCCs. Whole exome sequencing (WES) and targeted deep sequencing (TDS) were carried out in 32 multi-regional tumor ..
  44. Shek F, Luo R, Lam B, Sung W, Lam T, Luk J, et al. Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/?-catenin axis in hepatocellular carcinoma. Cell Oncol (Dordr). 2017;40:443-456 pubmed publisher
    ..In addition, we found that SPINK1 expression exhibited a positive correlation with CDH17 expression in human HCCs and was over-expressed in up to 70% of the tumors...
  45. Wang D, Zhu Z, Jiang H, Zhu J, Cong W, Wen B, et al. Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma. Hepatol Int. 2015;9:438-46 pubmed publisher
    ..87) and death (HR 3.00, 95% CI 1.26-7.13). A panel of 19 genes in 20q13.12-13.33 was significantly overexpressed in HCCs with gain compared to HCCs without...
  46. Chen C, Tsukamoto H, Machida K. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014;8:330-8 pubmed publisher
    ..oncogenic signaling pathways of tumor-initiating cells (TICs) in several etiologies of hepatocellular carcinomas (HCCs) induced by hepatitis C virus (HCV), alcohol, obesity and/or chemicals...
  47. Sadeghi M, Lahdou I, Oweira H, Daniel V, Terness P, Schmidt J, et al. Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma. Br J Cancer. 2015;113:756-62 pubmed publisher
    Most hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage. The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited...
  48. Teng F, Guo M, Liu F, Wang C, Dong J, Zhang L, et al. Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas. Oncotarget. 2016;7:53571-53582 pubmed publisher
    ..In summary, our research reveals a novel subset of HCCs that are sensitive to SLC12A1 antagonist treatment, thereby offering a new strategy for precision HCC treatment.
  49. Inoue T, Griffin D, Huq R, Samuel E, Ruano S, Stinnett G, et al. Characterization of a novel MR-detectable nanoantioxidant that mitigates the recall immune response. NMR Biomed. 2016;29:1436-44 pubmed publisher
    ..of a novel nanoantioxidant known as poly(ethylene glycol)-functionalized-hydrophilic carbon clusters (PEG-HCCs)...
  50. Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, et al. Shp2 promotes liver cancer stem cell expansion by augmenting ?-catenin signaling and predicts chemotherapeutic response of patients. Hepatology. 2017;65:1566-1580 pubmed publisher
    ..Herein, we observed high expression of Shp2 in both chemoresistant hepatocellular carcinomas (HCCs) and recurrent HCCs from patients...
  51. Cha D, Jang K, Kim S, Kang T, Song K. Liver Imaging Reporting and Data System on CT and gadoxetic acid-enhanced MRI with diffusion-weighted imaging. Eur Radiol. 2017;27:4394-4405 pubmed publisher
    ..Pairwise comparisons of the receiver operating characteristic (ROC) curves were performed. For HCCs, capsule appearance had the highest rate of discordance between CT and MRI (32...
  52. Xia C, Shui L, Lou G, Ye B, Zhu W, Wang J, et al. 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop. Sci Rep. 2017;7:4396 pubmed publisher
    ..MiR-34a expression was also down-regulated in HCCs compared with corresponding non-cancerous hepatic tissues...
  53. Kaemmerer D, Schindler R, Mußbach F, Dahmen U, Altendorf Hofmann A, Dirsch O, et al. Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets. BMC Cancer. 2017;17:896 pubmed publisher
    ..Expression of somatostatin receptor (SSTR) subtypes 1, 2A, 3, 4, and 5, and of CXCR4 was evaluated in a total of 71 HCCs and 27 CCCs by immunohistochemistry using well-characterized novel monoclonal antibodies...
  54. Yang X, Ye J, Yan H, Tang Z, Shen J, Zhang J, et al. MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-κB-mediated EMT. Tumour Biol. 2016;37:201-9 pubmed publisher
    ..Such process attenuated the CSCs-like properties in HCC cells. Our results point to a previously undefined mechanism by which miR-491 decreases CSCs-like properties and help to identify potential targets for the therapy of HCCs.
  55. Hayashi Y, Osanai M, Lee G. NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. Oncol Rep. 2015;34:1650-8 pubmed publisher
    ..Immunohistochemically, 19% of primary HCCs showed nuclear staining for NOTCH2, indicating activated NOTCH2 signaling...
  56. Hu L, Ye H, Huang G, Luo F, Liu Y, Liu Y, et al. Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21. Tumour Biol. 2016;37:2691-702 pubmed publisher
    ..Thus, GAS5 acts as a tumor suppressor in HCCs through negative regulation of miR-21 and its targets and proteins about migration and invasion in cancer cells, ..
  57. Zhou S, Hu Z, Zhou Z, Dai Z, Wang Z, Cao Y, et al. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. Hepatology. 2016;63:1560-75 pubmed publisher
    ..One of these, miR-28-5p, was down-regulated in HCCs. This down-regulation correlated with tumor metastasis, recurrence, and poor survival...
  58. Abe T, Amano H, Takechi H, Fujikuni N, Sasada T, Yoshida M, et al. Late-onset diaphragmatic hernia after percutaneous radiofrequency ablation of hepatocellular carcinoma: a case study. Surg Case Rep. 2016;2:25 pubmed publisher
    ..A 72-year-old woman with S5 and S8 HCCs was treated repeatedly with RFA and transcatheter arterial chemoembolization for 3 years...
  59. Feng J, Zhu R, Chang C, Yu L, Cao F, Zhu G, et al. CK19 and Glypican 3 Expression Profiling in the Prognostic Indication for Patients with HCC after Surgical Resection. PLoS ONE. 2016;11:e0151501 pubmed publisher
    ..CK19+/GPC3+ HCC has the shortest recurrence time compared to other immunophenotype HCCs. CK19 and GPC3 expression profiling is an independent prognostic indicator in patients with HCC, and a larger ..
  60. Joo I, Lee J, Lee S, Lee J, Park J, Han J. Diagnostic accuracy of liver imaging reporting and data system (LI-RADS) v2014 for intrahepatic mass-forming cholangiocarcinomas in patients with chronic liver disease on gadoxetic acid-enhanced MRI. J Magn Reson Imaging. 2016;44:1330-1338 pubmed publisher
    ..Pathologically confirmed IMCCs (n = 35) and hepatocellular carcinomas (HCCs) (n = 71) in patients with chronic hepatitis B or cirrhosis who had undergone gadoxetic acid-enhanced 3.0T or 1...
  61. Mebarki S, Désert R, Sulpice L, Sicard M, Desille M, Canal F, et al. De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas. Oncotarget. 2016;7:39026-39043 pubmed publisher
    About 20% hepatocellular carcinomas (HCCs) display wild-type ?-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of Wnt signals on HCC stem/progenitor cells...
  62. Dong F, Xu J, Du D, Jiao Y, Zhang L, Li M, et al. 3D analysis is superior to 2D analysis for contrast-enhanced ultrasound in revealing vascularity in focal liver lesions - A retrospective analysis of 83 cases. Ultrasonics. 2016;70:221-6 pubmed publisher
    ..Among the 83 cases, 61 were hepatocellular carcinomas (include 10 metastasis, 51 HCCs), and the remaining 22 were benign lesions: hemangiomas (n=15), focal nodular hyperplasias (n=4), and inflammatory ..
  63. Minami Y, Okumura N, Yamamoto N, Tsuji N, Kono Y, Kudo M. Quantification of tumor vascularity with contrast-enhanced ultrasound for early response of transcatheter arterial chemoembolization for hepatocellular carcinoma: a report of three cases. J Med Ultrason (2001). 2012;39:15-9 pubmed publisher
    ..Three patients (one man, two women) with HCCs were treated in July 2009...
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    ..The study included 116 patients (94 men, 22 women; mean age, 56.8 years) with surgically confirmed HCCs (n?=?87, 5.0-18.0 cm) or ICCs (n?=?29, 5.0-14.0 cm) who underwent gadoxetic acid MRI...
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    ..Clinico-pathological correlation revealed that PEDhigh HCCs showed an enrichment of gene signatures associated with metastasis and poor prognosis...
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    ..All the described de novo HCCs occurred at least 2 years after OLT, whereas most recurrent HCCs develop within 2 years from surgery...
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    ..Thirty-five patients (29 men and 6 women; mean age 60.7 years) with 40 HBV-related small HCCs who underwent complete RFA were included in our study...
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    ..significant correlation was found between AFP, AFP-L3%, and p53; however, the simultaneous determination of the three tumor markers yielded a better diagnostic accuracy and sensitivity in the detection of HCCs than each biomarker alone.
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    ..Although HCCs are soft cellular tumors, they may contain fibrous nests within the tumor mass...
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    ..ER stress, oxidative stress and NF?B signaling were found to be enhanced in a subset of HCCs, as well as in (precancerous) liver cirrhosis tissues...
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    ..chemoembolization is one of the established treatments for hepatocellular carcinoma (HCC), it is difficult to treat HCCs with prominent arterioportal (AP) shunts because anticancer drugs and embolic materials migrate into the non-..
  75. Ibrahim A, Schmithals C, Kowarz E, Köberle V, Kakoschky B, Pleli T, et al. Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial-Mesenchymal Transition. Clin Cancer Res. 2017;23:3896-3905 pubmed publisher
    ..HepG2-Dicer xenografts were established in nude mice; hypoxic areas and Dicer were detected in HCC xenografts and HCCs from mice with endogenous hepatocarcinogenesis; and epithelial-mesenchymal transition (EMT) markers were analyzed ..
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    ..Hsp90? expression, CD31 endothelial cell-dependent vessel density, and VEGFRs expression in tissue samples of 96 HCCs. Kaplan-Meier survival analysis and COX proportional hazards analysis the relation of Hsp90? and prognosis...
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    ..Phytochemical study on this tea led to the discovery of three hydroxycinnamoylated catechins (HCCs) (1-3), seven other catechins (4-10), three proanthocyanidins (11-13), five flavones and flavone glycosides (14-18),..
  78. Liu Z, Ning F, Wang H, Chen D, Cai Y, Sheng H, et al. Epidermal growth factor and tumor necrosis factor ? cooperatively promote the motility of hepatocellular carcinoma cell lines via synergistic induction of fibronectin by NF-?B/p65. Biochim Biophys Acta Gen Subj. 2017;1861:2568-2582 pubmed publisher
    ..Immunohistochemistry was performed to study the expression of EGF and TNF? in HCCs. Western blotting, immunofluorescence, qRT-PCR, wound healing scratch and invasion assay, and chromatin ..
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    ..The subjects consisted of 53 patients with 56 HCCs. The subjects included 12 well-differentiated, 35 moderately differentiated, and nine poorly differentiated HCCs...
  80. Kurucay M, Kloth C, Kaufmann S, Nikolaou K, Bösmüller H, Horger M, et al. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best?. Cancer Imaging. 2017;17:18 pubmed publisher
    ..In MRI, RIRHB was negative in 8/67. 12/67 HCCs were missed on DWI. 46/67 HCCs showed wash-in and 47/67 HCC showed wash-out of contrast agent...
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    ..sequence exhibiting similar levels of homology to the two yeast heme lyases Cyc3p (holocytochrome c synthase; HCCS) and Cyt2p (holocytochrome c1 synthase; HCC1S) is also targeted to mitochondria...
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    ..2 including the entire HCCS gene. The identification of a deletion including HCCS led to the diagnosis of MLS in these patients...
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    To evaluate histologic differentiation of hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived metrics and to compare findings with ..
  84. Hectors S, Wagner M, Bane O, Besa C, Lewis S, Remark R, et al. Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging. Sci Rep. 2017;7:2452 pubmed publisher
    ..b>HCCs exhibited significantly higher intra-tissue heterogeneity vs. liver with all MRI methods (P < 0.030)...
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    ..b>HCCs have significant amounts of genomic heterogeneity and multiple oncogenic pathways can be activated: the best ..
  86. Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, et al. Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE. Biochem Pharmacol. 2017;146:53-62 pubmed publisher
    ..regulator FUSE Binding Protein 1 (FUBP1) is overexpressed in more than 80% of all human hepatocellular carcinomas (HCCs) and other solid tumor entities including prostate and colorectal carcinoma...
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    Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer-related death worldwide. The majority of HCCs are diagnosed in a stage that is not eligible for curative resection...
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    ..place in the mitochondrial intermembrane space and, in most eukaryotes, is mediated by holocytochrome c synthase (HCCS). HCCS is the primary component of the eukaryotic cytochrome c biogenesis pathway, known as System III...
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    ..in guiding and assessing early therapeutic response to radiofrequency (RF) ablation for hepatocellular carcinomas (HCCs; up to 3 lesions, each ≤3 cm in diameter) and to report the short-term follow-up results...
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    ..Both SOD2 mRNA and protein are reduced in human primary HCCs compared with matching liver tissues...
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    ..More than 80% of hepatocellular carcinomas (HCCs) develop in fibrotic or cirrhotic livers, suggesting an important role of liver fibrosis in the premalignant ..
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    ..We compared the expression of SPZ1 and TWIST1 in specimens of hepatocarcinoma cells (HCCs) and non-HCCs...