HBP1

Summary

Gene Symbol: HBP1
Description: HMG-box transcription factor 1
Alias: HMG box-containing protein 1, high mobility group box transcription factor 1
Species: human
Products:     HBP1

Top Publications

  1. Wang W, Pan K, Chen Y, Huang C, Zhang X. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Nucleic Acids Res. 2012;40:981-95 pubmed publisher
    b>HBP1 is a sequence-specific DNA-binding transcription factor with many important biological roles. It activates or represses the expression of some specific genes during cell growth and differentiation...
  2. Pan K, Chen Y, Roth M, Wang W, Wang S, Yee A, et al. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Mol Cell Biol. 2013;33:887-903 pubmed publisher
    ..In this study, we demonstrated that the HMG box-containing protein 1 (HBP1) transcription factor is a new repressor of DNMT1 in a complex mechanism during senescence...
  3. Chen Y, Zhang X, Niu X, Xin D, Zhao W, Na Y, et al. Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer. Oncogene. 2010;29:3067-78 pubmed publisher
    ..In this study, we showed that the transcriptional repressor HBP1 (HMG box-containing protein 1) negatively regulates MIF expression...
  4. Li H, Wang W, Liu X, Paulson K, Yee A, Zhang X. Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. Oncogene. 2010;29:5083-94 pubmed publisher
    ..Our previous work indicated that the HMG box-containing protein 1 (HBP1) transcription factor is involved in Ras- and p38 MAPK-induced premature senescence, but the mechanism of which has ..
  5. Lemercier C, Duncliffe K, Boibessot I, Zhang H, Verdel A, Angelov D, et al. Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. Mol Cell Biol. 2000;20:6627-37 pubmed
    ..Interestingly, our cloning strategy led to the isolation of a retinoblastoma protein (RB) partner known as HBP1. HBP1, a high-mobility group box transcription factor, interacted specifically with the H1(0) H4 box and moreover ..
  6. Kim J, Zhang X, Rieger Christ K, Summerhayes I, Wazer D, Paulson K, et al. Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1. J Biol Chem. 2006;281:10865-75 pubmed
    ..The apparent mechanism targeted the HBP1 transcriptional repressor, which we had previously characterized as a suppressor of Wnt signaling...
  7. Lavender P, Vandel L, Bannister A, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene. 1997;14:2721-8 pubmed
    A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells...
  8. Escamilla Powers J, Daniel C, Farrell A, Taylor K, Zhang X, Byers S, et al. The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity. J Biol Chem. 2010;285:4847-58 pubmed publisher
    ..b>HBP1 was identified in our screen as a protein that interacts with full-length c-Myc but not a c-Myc mutant lacking the ..
  9. Paulson K, Rieger Christ K, McDevitt M, Kuperwasser C, Kim J, Unanue V, et al. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Cancer Res. 2007;67:6136-45 pubmed
    ..Our work combines clinical and molecular analyses to show that the transcriptional repressor HBP1 may be a new target for invasive breast cancer...

More Information

Publications63

  1. Tevosian S, Shih H, Mendelson K, Sheppard K, Paulson K, Yee A. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 1997;11:383-96 pubmed
    ..We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells...
  2. Li H, Bian C, Liao L, Li J, Zhao R. miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Res Treat. 2011;126:565-75 pubmed publisher
    ..The matching of miR-17-5p and HMG box-containing protein 1 (HBP1) was predicted by TargetScan and confirmed by DNA constructs and luciferase target assay...
  3. Berasi S, Xiu M, Yee A, Paulson K. HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase. Mol Cell Biol. 2004;24:3011-24 pubmed
    ..In this study, we demonstrate that the transcriptional repressor HBP1 (HMG box-containing protein 1) regulates the gene for the p47phox regulatory subunit of the NADPH oxidase...
  4. Shih H, Xiu M, Berasi S, Sampson E, Leiter A, Paulson K, et al. HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue. Mol Cell Biol. 2001;21:5723-32 pubmed
    We previously isolated HBP1 as a target of the retinoblastoma (RB) and p130 family members and as the first of the HMG box transcriptional repressors...
  5. Yao C, Works K, Romagnoli P, Austin G. Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. Leukemia. 2005;19:1958-68 pubmed
    HMG-box containing protein 1 (HBP1) is a member of the high mobility group (HMG) of chromosomal proteins...
  6. Zhang X, Kim J, Ruthazer R, McDevitt M, Wazer D, Paulson K, et al. The HBP1 transcriptional repressor participates in RAS-induced premature senescence. Mol Cell Biol. 2006;26:8252-66 pubmed
    ..Here, we demonstrate that the HBP1 transcriptional repressor participates in RAS- and p38 MAPK-induced premature senescence...
  7. Sampson E, Haque Z, Ku M, Tevosian S, Albanese C, Pestell R, et al. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. EMBO J. 2001;20:4500-11 pubmed
    ..In mammals, the transcriptional repressors in the Wnt pathway are not well defined. We have previously identified HBP1 as an HMG-box repressor and a cell cycle inhibitor...
  8. Zhuma T, Tyrrell R, Sekkali B, Skavdis G, Saveliev A, Tolaini M, et al. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J. 1999;18:6396-406 pubmed
    ..Here, we identified the HMG box containing protein-1 (HBP1) as a factor binding to HSS3 of the hCD2 LCR...
  9. Ying H, Gong M, Pi C. Generation and reactivity of neutral 1,3-benzazaphosphole and anionic 1,3-benzazaphospholide ytterbium(iii) complexes. Dalton Trans. 2019;48:2722-2729 pubmed publisher
    Treatment of Cp3Ln (Ln = Yb, Y) with 5-R3-6-R1-2-R2-1H-1,3-benzazaphosphole (HBp) (HBp1 (1a): R1 = H, R2 = 2,4,6-Me3C6H2, R3 = Me; HBp2(1b): R1 = Me, R2 = C6H5, R3 = H; HBp3(1c): R1 = R3 = H, R2 = C6H5) at room temperature gives the ..
  10. Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, et al. MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1. Oncogene. 2019;: pubmed publisher
    ..Our data demonstrated that the transcription factor HBP1 is a target of MDM2...
  11. Bollaert E, de Rocca Serra A, Demoulin J. The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways. Cell Mol Life Sci. 2019;76:1529-1539 pubmed publisher
    HMG box protein 1 (HBP1) is a transcription factor and a potent cell cycle inhibitor in normal and cancer cells...
  12. Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober O, et al. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ. 2010;17:1896-907 pubmed publisher
    ..targets of p63 in keratinocytes, we identified the transcription factor, High Mobility Group (HMG) box protein 1 (HBP1). HBP1 is an HMG-containing repressor transiently induced during differentiation of several cell lineages...
  13. Warden B, Duell P. Volanesorsen for treatment of patients with familial chylomicronemia syndrome. Drugs Today (Barc). 2018;54:721-735 pubmed publisher
    ..factor 1 (LMF1) and glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPI-HBP1). FCS is associated with severe morbidity that includes recurrent pancreatitis and other problems...
  14. Song X, Gao X, Lu J, Liang H, Su P, Li Q, et al. High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation. Dev Growth Differ. 2018;60:146-157 pubmed publisher
    High mobility group (HMG) box-containing protein 1 (HBP1) is a member of the HMG family of chromosomal proteins. Previous studies have shown that human HBP1 exhibits tumor-suppressor activity...
  15. McGrath J, Panzica L, Ransom R, Withers H, Gelman I. Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures. Mol Cancer Res. 2019;17:860-869 pubmed publisher
    ..Several potential DRSG were confirmed using independent shRNAs, including BHLHE41, HBP1, and WNT3...
  16. Zhou W, Duan M, Fu W, Pang J, Tang Q, Sun H, et al. Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays. Genomics Proteomics Bioinformatics. 2018;16:416-427 pubmed publisher
    ..A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them (HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD...
  17. Sanghvi V, Mavrakis K, Van der Meulen J, Boice M, Wolfe A, Carty M, et al. Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia. Sci Signal. 2014;7:ra111 pubmed publisher
    ..the convergence of a small group of tumor suppressor miRNAs on the Myb oncogene, as well as their effects on HBP1, which encodes a transcription factor...
  18. Claeys S, Denecker G, Durinck K, Decaesteker B, Mus L, Loontiens S, et al. ALK positively regulates MYCN activity through repression of HBP1 expression. Oncogene. 2019;38:2690-2705 pubmed publisher
    ..We show that mutant ALK downregulates the 'HMG-box transcription factor 1' (HBP1) through the PI3K-AKT-FOXO3a signaling axis...
  19. Fan L, Teng L, Li J. Knockout of p47 phox uncovers a critical role of p40 phox in reactive oxygen species production in microvascular endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:1651-6 pubmed publisher
    ..The transcriptional regulation of p40(phox) and p47(phox) expressions involves HBP1. p40(phox) was prephosphorylated in resting cells...
  20. Pooja T, Karunagaran D. Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Eur J Pharmacol. 2014;742:55-64 pubmed publisher
    ..Two novel targets of emodin׳s action were discovered namely Wnt co-activator p300 (down regulated) and repressor HBP1 (up regulated)...
  21. Yan Z, Che S, Wang J, Jiao Y, Wang C, Meng Q. miR-155 contributes to the progression of glioma by enhancing Wnt/β-catenin pathway. Tumour Biol. 2015;36:5323-31 pubmed publisher
    ..indicated that miR-155 level was inversely correlated with the abundance of HMG-box transcription factor 1 (HBP1), a strong Wnt pathway inhibitor, in glioma samples...
  22. Feng Y, Feng C, Chen S, Hsieh H, Chen Y, Hsu C. Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. BMC Cancer. 2015;15:134 pubmed publisher
    ..The cyproheptadine-induced G1 arrest in HepG2 cells was associated with an increased expression of HBP1 and p16, whereas the G1/S arrest in Huh-7 cells was associated with an increase in p21 and p27 expression and a ..
  23. Wang Y, Zhou T, Wan J, Yang Y, Chen X, Wang J, et al. Comparative transcriptome analysis reveals a regulatory network of microRNA-29b during mouse early embryonic development. Oncotarget. 2016;7:53772-53782 pubmed publisher
    ..We identified 19 genes encoding putative miR-29b target transcripts. These included Zbtb40, Hbp1, Ccdc117, Ypel2, Klf4, and Tmed9, which are upregulated at the 4-cell state of mouse development concomitant with ..
  24. Li Y, Choi P, Casey S, Dill D, Felsher D. MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a neoplastic state. Cancer Cell. 2014;26:262-72 pubmed publisher
    ..that MYC via miR-17-92 maintains a neoplastic state through the suppression of chromatin regulatory genes Sin3b, Hbp1, Suv420h1, and Btg1, as well as the apoptosis regulator Bim...
  25. He S, Yang S, Niu M, Zhong Y, Dan Gao -, Zhang Y, et al. HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma. Cell Death Dis. 2018;9:100 pubmed publisher
    HMG-box transcription factor 1 (HBP1) has been reported to be a tumor suppressor in diverse malignant carcinomas...
  26. Ding Y, Chen J, Okon I, Zou M, Song P. Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts. Int J Biochem Cell Biol. 2016;71:72-80 pubmed publisher
    ..Interestingly, knockdown of HMG box-containing protein 1 (HBP1) partially blocked the cellular senescence of AMPKα2-deleted MEFs via the reduction of p16...
  27. Xie K, Ma H, Liang C, Wang C, Qin N, Shen W, et al. A functional variant in miR-155 regulation region contributes to lung cancer risk and survival. Oncotarget. 2015;6:42781-92 pubmed publisher
    ..the transcriptional activity of miR-155, which in turn facilitated tumor growth and metastasis by inhibiting HBP1, TJP1, SMAD5 and PRKAR1A expression...
  28. Ciribilli Y, Singh P, Spanel R, Inga A, Borlak J. Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas. Oncotarget. 2015;6:31569-92 pubmed publisher
    ..at promoters of genes regulated in transgenic but non-carcinomatous lung tissue enriched binding sites for c-Myc, Hbp1, Hif1 were observed...
  29. Kanteev M, Bregman Cohen A, Deri B, Shahar A, Adir N, Fishman A. A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism. Biochim Biophys Acta. 2015;1854:1906-1913 pubmed publisher
    ..We have determined the structure of HbpA from the soil bacterium Pseudomonas azelaica HBP1 with bound 2-hydroxybiphenyl, as well as several variants, at a resolution of 2.3-2...
  30. Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle V, Havelange V, et al. HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation. Cell Signal. 2018;44:158-170 pubmed publisher
    The HMG-box protein 1 (HBP1) is a transcriptional regulator and a potential tumor suppressor that controls cell proliferation, differentiation and oncogene-mediated senescence...
  31. Liu R, Wang M, SU L, Li X, Zhao S, Yu M. The Expression Pattern of MicroRNAs and the Associated Pathways Involved in the Development of Porcine Placental Folds That Contribute to the Expansion of the Exchange Surface Area. Biol Reprod. 2015;93:62 pubmed publisher
    ..epithelial cell adherens junctions (the miR-200 family and miR-205-ZEB2-CDH1) and proliferation (miR-17-92 cluster-HBP1 and ULK1)...
  32. Spiller C, Wilhelm D, Jans D, Bowles J, Koopman P. Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS ONE. 2017;12:e0170576 pubmed publisher
    ..High mobility group box containing transcription factor 1 (HBP1) is a transcription factor that was previously identified in fetal male germ cells at the time of embryonic cell ..
  33. Raine E, Wreglesworth N, Dodd A, Reynard L, Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Ann Rheum Dis. 2012;71:2020-7 pubmed publisher
    ..has been mapped to chromosome 7q22, to a region of high-linkage disequilibrium encompassing six genes: PRKAR2B, HBP1, COG5, GPR22, DUS4L and BCAP29...
  34. Tseng R, Huang W, Lin S, Wu P, Hsu H, Wang Y. HBP1 promoter methylation augments the oncogenic ?-catenin to correlate with prognosis in NSCLC. J Cell Mol Med. 2014;18:1752-61 pubmed publisher
    ..The HMG-box transcription factor 1 (HBP1) is a known repressor of ?-catenin transactivation...
  35. Chan C, Huang S, Sheu J, Roth M, Chou I, Lien C, et al. Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer. Oncotarget. 2017;8:14537-14548 pubmed publisher
    Either FOXO1 or HBP1 transcription factor is a downstream effector of the PI3K/Akt pathway and associated with tumorigenesis. However, the relationship between FOXO1 and HBP1 in oral cancer remains unclear...
  36. Elfert S, Weise A, Bruser K, Biniossek M, Jägle S, Senghaas N, et al. Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. PLoS ONE. 2013;8:e61867 pubmed publisher
    ..a conformational change that may also represent the mechanism whereby acetylated TCF4E acquires resistance against HBP1. In summary, TCF4 not only recruits acetyltransferases but is also a substrate for these enzymes...
  37. Zhang Y, Gao Y, Zhao L, Han L, Lu Y, Hou P, et al. Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells. FEBS J. 2013;280:4625-39 pubmed publisher
    ..Furthermore, HMG box transcription factor 1 (HBP1), a downstream target of the mitogen-activated protein kinase p38-mediated senescence pathway, was required for ..
  38. Chen H, Li X, Liu S, Gu L, Zhou X. MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. Sci Rep. 2017;7:12089 pubmed publisher
    ..We identify HMG-Box Transcription Factor 1 (HBP-1) as a target gene of miR-19a. HBP1 is repressor of macrophage migration inhibiting factor (MIF) and overexpression of miR-19a increases MIF expression...
  39. Swanson K, Knoepfler P, Huang K, Kang R, Cowley S, Laherty C, et al. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat Struct Mol Biol. 2004;11:738-46 pubmed
    ..Here we show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner ..
  40. Wan Y, Li T, Han Y, Zhang H, Lin H, Zhang B. MicroRNA-155 enhances the activation of Wnt/β-catenin signaling in colorectal carcinoma by suppressing HMG-box transcription factor 1. Mol Med Rep. 2016;13:2221-8 pubmed publisher
    ..HMG‑box transcription factor 1 (HBP1) was identified as a novel target of miR‑155, which mediated its effect on CRC via the Wnt/β‑..
  41. Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos K, Burgering B, et al. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. Biochem J. 2014;460:25-34 pubmed publisher
    ..By comparing microarray data from multiple model systems, we identified HBP1 (high-mobility group-box protein 1) as a novel downstream target of this pathway...
  42. Sun X, Geng X, Zhang J, Zhao H, Liu Y. miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism. Mol Cell Biochem. 2015;403:139-47 pubmed publisher
    ..Wnt pathway was suppressed in OS cells by miR-155 inhibitors. HMG-box transcription factor 1 (HBP1), a strong Wnt pathway suppressor, was found to be a target of miR-155...
  43. Yan Z, Wang J, Wang C, Jiao Y, Qi W, Che S. miR-96/HBP1/Wnt/?-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 2014;588:3038-46 pubmed publisher
    ..On the other hand, HBP1 silencing promotes miR-96 expression...
  44. de Chiara C, Kelly G, Frenkiel T, Pastore A. Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1. J Biomol NMR. 2004;28:411-2 pubmed
  45. Chan C, Yu P, Chang F, Chen Z, Lee M, Huang C. Transcription factor HMG box-containing protein 1 (HBP1) modulates mitotic clonal expansion (MCE) during adipocyte differentiation. J Cell Physiol. 2017;: pubmed publisher
    Transcription factor HMG box-containing protein 1 (HBP1) has been found to be up-regulated in rat adipose tissue and differentiated preadipocyte; however, how HBP1 is involved in adipocyte formation remains unclear...
  46. Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed publisher
    ..In this study, we demonstrate that the high-mobility group box-containing protein 1 (HBP1) transcription factor is a novel activator of p21 that works as part of a complex mechanism during senescence and ..
  47. Myslinski E, Gérard M, Krol A, Carbon P. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. J Biol Chem. 2006;281:39953-62 pubmed
    ..Furthermore, we demonstrated that the presence of the SBS alone is sufficient to direct expression of a luciferase reporter gene, suggesting that hStaf/ZNF143 can recruit per se the transcription machinery. ..
  48. Lee M, Hsieh N, Huang C, Li C. All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/β-Catenin Signaling in Human Colorectal Cancer Cells. J Cell Physiol. 2016;231:1796-803 pubmed publisher
    ..D1, c-Myc, and nuclear β-catenin, but increased the expression of E-cadherin and HMG box-containing protein 1 (HBP1) where HBP1 has been described as a negative regulator of the Wnt/β-catenin signaling...
  49. Wen Z, Pan T, Yang S, Liu J, Tao H, Zhao Y, et al. Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ. Mol Cancer. 2017;16:20 pubmed publisher
    ..Genechip-scanning speculated downstream target HBP1. Western blot, ChIP and luciferase reporter were carried to investigate the interaction between NRIP2, RORβ, and ..
  50. Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, et al. Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell Death Differ. 2016;23:1602-14 pubmed publisher
    ..The results uncovered roles for several tumor suppressors, including HBP1, in the augmentation of mitochondrial function...
  51. Chen Y, Wang Y, Yu Y, Xu L, Zhang Y, Yu S, et al. Transcription Factor HBP1 Enhances Radiosensitivity by Inducing Apoptosis in Prostate Cancer Cell Lines. Anal Cell Pathol (Amst). 2016;2016:7015659 pubmed publisher
    ..b>HBP1 (HMG-box transcription factor 1) is a transcriptional inhibitor which could inhibit the expression of dozens of ..
  52. Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, et al. A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. J Biol Chem. 2017;292:8207-8222 pubmed publisher
    ..Pim-1 binds to and phosphorylates the transcription factor high mobility group box transcription factor 1 (HBP1), activating it...
  53. Sekkali B, Szabat E, Ktistaki E, Tolaini M, Roderick K, Harker N, et al. Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation. J Immunol. 2005;175:5203-12 pubmed
    ..In this study we show that thymus-specific overexpression of human high mobility group box transcription factor 1 (HBP1), a transcription factor that binds a specific sequence within the hCD2 LCR, affects ..
  54. Watanabe N, Kageyama R, Ohtsuka T. Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression. Development. 2015;142:2278-90 pubmed publisher
    ..expression profiling of embryonic NSCs in the cortical regions and found that expression of high mobility group box transcription factor 1 (Hbp1) was upregulated during neurogenic stages...