HAUS8

Summary

Gene Symbol: HAUS8
Description: HAUS augmin like complex subunit 8
Alias: DGT4, HICE1, NY-SAR-48, HAUS augmin-like complex subunit 8, HEC1/NDC80 interacting, centrosome associated 1, HEC1/NDC80-interacting centrosome-associated protein 1, Hec1-interacting and centrosome-associated 1, sarcoma antigen NY-SAR-48
Species: human
Products:     HAUS8

Top Publications

  1. Lee S, Obata Y, Yoshida M, Stockert E, Williamson B, Jungbluth A, et al. Immunomic analysis of human sarcoma. Proc Natl Acad Sci U S A. 2003;100:2651-6 pubmed
    ..NY-SAR-35 is therefore a potential target for cancer vaccines and monoclonal antibody-based immunotherapies. ..
  2. Goshima G, Mayer M, Zhang N, Stuurman N, Vale R. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol. 2008;181:421-9 pubmed publisher
    ..Our results suggest that an important mitotic function for gamma-tubulin may lie within the spindle, where augmin and gamma-tubulin function cooperatively to amplify the number of microtubules. ..
  3. Wu G, Wei R, Cheng E, Ngo B, Lee W. Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1. Mol Biol Cell. 2009;20:4686-95 pubmed publisher
    ..Here, we show that Hec1 specifically colocalizes with Hice1, a previously characterized centrosomal microtubule-binding protein, at the spindle pole region during mitosis...
  4. Wu G, Lin Y, Wei R, Chen Y, Shan Z, Lee W. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol Cell Biol. 2008;28:3652-62 pubmed publisher
    ..Here we report the characterization of a previously identified human sarcoma antigen (gene located at 19p13.11), Hice1, an evolutionarily nonconserved 46-kDa coiled-coil protein...
  5. Uehara R, Nozawa R, Tomioka A, Petry S, Vale R, Obuse C, et al. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009;106:6998-7003 pubmed publisher
    ..These results demonstrate that MT generation mediated by augmin and gamma-TuRC is critical for chromosome segregation and cytokinesis in human cells. ..
  6. Lawo S, Bashkurov M, Mullin M, Ferreria M, Kittler R, Habermann B, et al. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol. 2009;19:816-26 pubmed publisher
    ..The human Augmin complex (HAUS) is a critical and evolutionary conserved multisubunit protein complex that regulates centrosome and spindle integrity. ..
  7. Tsai C, Ngo B, Tapadia A, Hsu P, Wu G, Lee W. Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. J Biol Chem. 2011;286:30097-106 pubmed publisher
    Proper assembly of mitotic spindles requires Hice1, a spindle-associated protein...
  8. Hsia K, Wilson Kubalek E, Dottore A, Hao Q, Tsai K, Forth S, et al. Reconstitution of the augmin complex provides insights into its architecture and function. Nat Cell Biol. 2014;16:852-63 pubmed publisher
    ..Together, our findings shed light on augmin's structural organization and microtubule-binding properties, and define subunits required for its function in organizing microtubule-based structures. ..