HARS2

Summary

Gene Symbol: HARS2
Description: histidyl-tRNA synthetase 2, mitochondrial
Alias: HARSL, HARSR, HO3, PRLTS2, HARS-related, hisRS, histidine tRNA ligase 2, mitochondrial (putative), histidine translase, histidine-tRNA ligase homolog, histidyl-tRNA synthetase 2, mitochondrial (putative)
Species: human
Products:     HARS2

Top Publications

  1. Englert M, Vargas Rodriguez O, Reynolds N, Wang Y, Söll D, Umehara T. A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair. Biochim Biophys Acta. 2017;1861:3009-3015 pubmed publisher
    ..The Escherichia coli and Caulobacter crescentus histidyl-tRNA synthetases (HisRS) evolved divergent mechanisms of tRNAHis recognition that prevent their cross-reactivity...
  2. Angeli G, Sartsidou C, Vlahaki S, Spanopoulos I, Tsangarakis C, Kourtellaris A, et al. Reticular Chemistry and the Discovery of a New Family of Rare Earth (4, 8)-Connected Metal-Organic Frameworks with csq Topology Based on RE4(?3-?)2(COO)8 Clusters. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..report here a new family of RE-MOFs featuring the novel inorganic building unit, RE4(?3-?)2 (RE: Y3+, Tb3+, Dy3+, Ho3+, Er3+ and Yb3+), with planar D2h symmetry...
  3. Lu D, Guan D. Photoluminescence associated with the site occupations of Ho3+ ions in BaTiO3. Sci Rep. 2017;7:6125 pubmed publisher
    ..The PL effect may provide a probe for the site occupations of Ho3+ ions in widely-used BaTiO3 dielectric ceramics co-doped with Ho3+ and other dopants. ..
  4. Pierce S, Chisholm K, Lynch E, Lee M, Walsh T, Opitz J, et al. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A. 2011;108:6543-8 pubmed publisher
    ..of Perrault syndrome to be compound heterozygosity for mutations in the mitochondrial histidyl tRNA synthetase HARS2 at two highly conserved amino acids, L200V and V368L. The nucleotide substitution creating HARS2 p...
  5. O Hanlon T, Raben N, Miller F. A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. Biochem Biophys Res Commun. 1995;210:556-66 pubmed
    ..DNA clone that encodes portions of these oppositely transcribed mRNAs and a putatively full-length cDNA clone (HO3) corresponding to the gene mapping immediately 5' of HRS...
  6. Tsui H, Mok S, de Souza L, Martin A, Tsui F. Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element. Gene. 1993;131:201-8 pubmed
    ..From mobility shift assays using HeLa cell nuclear extracts and this 27-bp oligo, we have identified two DNA-protein complexes, both of which are presumably required to initiate bidirectional transcription. ..
  7. Raben N, Borriello F, Amin J, Horwitz R, Fraser D, Plotz P. Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. Nucleic Acids Res. 1992;20:1075-81 pubmed
  8. Xu X, Zhou S, Long J, Wu T, Fan Z. The Synthesis of a Core-Shell Photocatalyst Material YF?:Ho3+@TiO? and Investigation of Its Photocatalytic Properties. Materials (Basel). 2017;10: pubmed publisher
  9. Fan Z, Wu T, Xu X. Synthesis of Reduced Grapheme Oxide as A Platform for loading ?-NaYF4:Ho3+@TiO2Based on An Advanced Visible Light-Driven Photocatalyst. Sci Rep. 2017;7:13833 pubmed publisher
    ..It is of great significance to design an effective solar light-driven photocatalysis in promoting environmental protection. ..
  10. Hong Y, Yi T, Tan X, Su J, Ge F. Microbes affected the TYLCCNV transmission rate by the Q biotype whitefly under high O3. Sci Rep. 2017;7:14412 pubmed publisher
    ..In this study we studied how hO3 affected the transmission of the Tomato yellow leaf curl China virus (TYLCCNV), a begomovirus, by the Q biotype ..

Detail Information

Publications24

  1. Englert M, Vargas Rodriguez O, Reynolds N, Wang Y, Söll D, Umehara T. A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair. Biochim Biophys Acta. 2017;1861:3009-3015 pubmed publisher
    ..The Escherichia coli and Caulobacter crescentus histidyl-tRNA synthetases (HisRS) evolved divergent mechanisms of tRNAHis recognition that prevent their cross-reactivity...
  2. Angeli G, Sartsidou C, Vlahaki S, Spanopoulos I, Tsangarakis C, Kourtellaris A, et al. Reticular Chemistry and the Discovery of a New Family of Rare Earth (4, 8)-Connected Metal-Organic Frameworks with csq Topology Based on RE4(?3-?)2(COO)8 Clusters. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..report here a new family of RE-MOFs featuring the novel inorganic building unit, RE4(?3-?)2 (RE: Y3+, Tb3+, Dy3+, Ho3+, Er3+ and Yb3+), with planar D2h symmetry...
  3. Lu D, Guan D. Photoluminescence associated with the site occupations of Ho3+ ions in BaTiO3. Sci Rep. 2017;7:6125 pubmed publisher
    ..The PL effect may provide a probe for the site occupations of Ho3+ ions in widely-used BaTiO3 dielectric ceramics co-doped with Ho3+ and other dopants. ..
  4. Pierce S, Chisholm K, Lynch E, Lee M, Walsh T, Opitz J, et al. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A. 2011;108:6543-8 pubmed publisher
    ..of Perrault syndrome to be compound heterozygosity for mutations in the mitochondrial histidyl tRNA synthetase HARS2 at two highly conserved amino acids, L200V and V368L. The nucleotide substitution creating HARS2 p...
  5. O Hanlon T, Raben N, Miller F. A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. Biochem Biophys Res Commun. 1995;210:556-66 pubmed
    ..DNA clone that encodes portions of these oppositely transcribed mRNAs and a putatively full-length cDNA clone (HO3) corresponding to the gene mapping immediately 5' of HRS...
  6. Tsui H, Mok S, de Souza L, Martin A, Tsui F. Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element. Gene. 1993;131:201-8 pubmed
    ..From mobility shift assays using HeLa cell nuclear extracts and this 27-bp oligo, we have identified two DNA-protein complexes, both of which are presumably required to initiate bidirectional transcription. ..
  7. Raben N, Borriello F, Amin J, Horwitz R, Fraser D, Plotz P. Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. Nucleic Acids Res. 1992;20:1075-81 pubmed
  8. Xu X, Zhou S, Long J, Wu T, Fan Z. The Synthesis of a Core-Shell Photocatalyst Material YF?:Ho3+@TiO? and Investigation of Its Photocatalytic Properties. Materials (Basel). 2017;10: pubmed publisher
  9. Fan Z, Wu T, Xu X. Synthesis of Reduced Grapheme Oxide as A Platform for loading ?-NaYF4:Ho3+@TiO2Based on An Advanced Visible Light-Driven Photocatalyst. Sci Rep. 2017;7:13833 pubmed publisher
    ..It is of great significance to design an effective solar light-driven photocatalysis in promoting environmental protection. ..
  10. Hong Y, Yi T, Tan X, Su J, Ge F. Microbes affected the TYLCCNV transmission rate by the Q biotype whitefly under high O3. Sci Rep. 2017;7:14412 pubmed publisher
    ..In this study we studied how hO3 affected the transmission of the Tomato yellow leaf curl China virus (TYLCCNV), a begomovirus, by the Q biotype ..
  11. Xing L, Yang W, Lin J, Huang M, Xue Y. Enhanced and Stable Upconverted White-light Emission in Ho3+/Yb3+/Tm3+-doped LiNbO3 Single Crystal via Mg2+ Ion Doping. Sci Rep. 2017;7:14725 pubmed publisher
    ..Therefore, Mg2+ ion doped Ho3+/Yb3+/Tm3+/LiNbO3 single crystals would have potential applications in stable white-light devices and photoelectric instruments. ..
  12. Abbott J, Guth E, Kim C, Regan C, Siu V, Rupar C, et al. The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Biochemistry. 2017;56:3619-3631 pubmed publisher
    ..revealed that the kinetics of amino acid activation differs from that of the previously characterized bacterial HisRS. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than ..
  13. Peng L, Huang Y, Duan Y, Zhuang S, Liao T, Xu C. 2???m laser oscillation of Ho3+:Tm3+-codoped silica microspheres. Appl Opt. 2017;56:7469-7473 pubmed publisher
    ..The free spectral range is in good accordance with the calculated value based on Mie scattering theory. The HTCSM laser oscillation shows characteristics of good capability, simple process, high flexibility, and low cost...
  14. Xiang G, Ma Y, Liu W, Wang J, Gu Z, Jin Y, et al. Enhancement of Eu3+ Red Upconversion in Lu2O3: Yb3+/Eu3+ Powders under the Assistance of Bridging Function Originated from Ho3+ Tridoping. Inorg Chem. 2017;56:13955-13961 pubmed publisher
    ..5 mol % Ho3+ is increased by a factor of 8...
  15. Syamchand S, Aparna R, George S. Surface Engineered Ho3+ Incorporated Fluorescent Dye-Doped Bifunctional Silica Nanoparticles for Receptor Targeted Fluorescence Imaging and Potential Magnetic Resonance Imaging. J Fluoresc. 2017;27:1897-1908 pubmed publisher
    ..The luminescence and magnetism together with biocompatibility enables the adaptability of the present system as a nano platform for potential bimodal imaging. Graphical Abstract ?. ..
  16. Kosaki R, Horikawa R, Fujii E, Kosaki K. Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms. Am J Med Genet A. 2018;176:404-408 pubmed publisher
    ..Causative genes include HARS2, HSD17B4, CLPP, C10orf2, and LARS2...
  17. Freist W, Verhey J, Rühlmann A, Gauss D, Arnez J. Histidyl-tRNA synthetase. Biol Chem. 1999;380:623-46 pubmed
    Histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins...
  18. Pilch A, Würth C, Kaiser M, Wawrzynczyk D, Kurnatowska M, Arabasz S, et al. Shaping Luminescent Properties of Yb3+ and Ho3+ Co-Doped Upconverting Core-Shell ?-NaYF4 Nanoparticles by Dopant Distribution and Spacing. Small. 2017;: pubmed publisher
  19. Sirusi A, Suh E, Kovacs Z, Merritt M. The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T. Phys Chem Chem Phys. 2018;20:728-731 pubmed publisher
    ..The optimum Ho-DOTA concentration was 2 mM. In addition, the microwave sweep spectrum changes character in a manner that suggests both the cross effect and thermal mixing are active mechanisms for trityl radical at 5 T and 1.2 K. ..
  20. Zhang J, Lu Y, Cai M, Tian Y, Huang F, Guo Y, et al. 2.8??m emission and OH quenching analysis in Ho3+ doped fluorotellurite-germanate glasses sensitized by Yb3+ and Er3. Sci Rep. 2017;7:16794 pubmed publisher
    ..Results reveal that Er3+/Ho3+/Yb3+ triply-doped fluorotellurite-germanate glass is a potential kind of laser glass for efficient 3??m laser. ..
  21. Fulle K, Sanjeewa L, McMillen C, Kolis J. Crystal chemistry and the role of ionic radius in rare earth tetrasilicates: Ba2RE2Si4O12F2 (RE = Er3+-Lu3+) and Ba2RE2Si4O13 (RE = La3+-Ho3+). Acta Crystallogr B Struct Sci Cryst Eng Mater. 2017;73:907-915 pubmed publisher
    ..The single crystals are grown from high-temperature (ca 953?K) hydrothermal fluids, demonstrating the versatility of the technique to access new phases containing recalcitrant rare earth oxides, enabling the study of structural trends...
  22. Wei C, Shi H, Luo H, Zhang H, Lyu Y, Liu Y. 34 nm-wavelength-tunable picosecond Ho3+/Pr3+-codoped ZBLAN fiber laser. Opt Express. 2017;25:19170-19178 pubmed publisher
    ..Such simple, robust, and versatile mid-infrared picosecond laser source can find various applications in laser surgery, spectroscopy, and nonlinear frequency conversion...
  23. Lama J, Trono D. Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3. J Virol. 1998;72:1671-6 pubmed
    ..A specific interaction between MA and HO3, a putative histidyl-tRNA synthetase, was demonstrated in this system...