HAP1

Summary

Gene Symbol: HAP1
Description: huntingtin associated protein 1
Alias: HAP2, HIP5, HLP, hHLP1, huntingtin-associated protein 1, HAP-1, huntingtin-associated protein 2, neuroan 1
Species: human
Products:     HAP1

Top Publications

  1. Wu L, Zhou X. Huntingtin associated protein 1 and its functions. Cell Adh Migr. 2009;3:71-6 pubmed
    ..Several studies suggest that Htt and huntingtin associated protein 1 (HAP1) participate in intracellular trafficking and that polyglutamine expansion affects vesicular ..
  2. Bertaux F, Sharp A, Ross C, Lehrach H, Bates G, Wanker E. HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. FEBS Lett. 1998;426:229-32 pubmed
    b>HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's ..
  3. Yang M, Lim Y, Li X, Zhong J, Zhou X. Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J Biol Chem. 2011;286:16272-84 pubmed publisher
    ..In this study, we report that proBDNF forms a complex with Huntingtin associated protein-1 (HAP1) and sortilin, which plays an important role in proBDNF intracellular trafficking and stabilization...
  4. Li X, Li S, Sharp A, Nucifora F, Schilling G, Lanahan A, et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature. 1995;378:398-402 pubmed
    ..The HAP-1 protein is enriched in the brain, suggesting a possible basis for the selective brain pathology of HD. ..
  5. Engelender S, Sharp A, Colomer V, Tokito M, Lanahan A, Worley P, et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet. 1997;6:2205-12 pubmed
    ..We previously identified a protein (HAP1) which binds to huntingtin in a glutamine repeat length-dependent manner...
  6. Li S, Gutekunst C, Hersch S, Li X. Interaction of huntingtin-associated protein with dynactin P150Glued. J Neurosci. 1998;18:1261-9 pubmed
    ..Huntingtin-associated protein (HAP1) is a neuronal protein and binds to huntingtin in association with the polyglutamine repeat...
  7. Keryer G, Pineda J, Liot G, Kim J, Dietrich P, Benstaali C, et al. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest. 2011;121:4372-82 pubmed publisher
    ..Here, we demonstrate that WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1)...
  8. Yang G, Yang M, Lim Y, Lu J, Wang T, Qi J, et al. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem. 2012;122:1010-22 pubmed publisher
    ..However, the mechanism of APP trafficking remains unclear. We present evidence that huntingtin associated protein 1 (HAP1) may reduce A? production by regulating APP trafficking to the non-amyloidogenic pathway...
  9. Joshi S, Clapp W, Wang W, Khan S. Osteogenic changes in kidneys of hyperoxaluric rats. Biochim Biophys Acta. 2015;1852:2000-12 pubmed publisher
    ..To test our hypothesis male rats were made hyperoxaluric by administration of hydroxy-l-proline (HLP). After 28days, rat kidneys were extracted...

More Information

Publications115 found, 100 shown here

  1. Galdieri L, Zhang T, Rogerson D, Vancura A. Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration. Mol Cell Biol. 2016;36:1064-77 pubmed publisher
    ..structure is associated with the induction of the retrograde (RTG) pathway and requires the activity of the Hap2/3/4/5p complex as well as the transport and metabolism of pyruvate in mitochondria...
  2. Marz W, Grammer T, Delgado G, Kleber M. [Congenital disorders of lipoprotein metabolism]. Herz. 2017;42:449-458 pubmed publisher
    ..Other monogenic hyperlipoproteinemias (HLP) affect the catabolism of chylomicrons (familial chylomicronemia) or of remnants of triglyceride-rich lipoproteins (..
  3. Fang Y, van Meurs J, Arp P, van Leeuwen J, Hofman A, Pols H, et al. Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int. 2009;85:85-93 pubmed publisher
    ..09 g/day, the hazard ratio (95% confidence interval) for fracture risk of DBP hap1-homozygote versus noncarrier was 1.47 (1.06-2.05). All associations were independent of age and gender...
  4. Validi M, Karkhah A, Prajapati V, Nouri H. Immuno-informatics based approaches to design a novel multi epitope-based vaccine for immune response reinforcement against Leptospirosis. Mol Immunol. 2018;104:128-138 pubmed publisher
    ..Therefore, this study was conducted to construct a novel multi-epitope based vaccine against leptospirosis by using Hap1, LigA, LAg42, SphH and HSP58 antigens. T cell and IFN gamma epitopes were predicted from these antigens...
  5. Gui L, Hong J, Raza S, Zan L. Genetic variants in SIRT3 transcriptional regulatory region affect promoter activity and fat deposition in three cattle breeds. Mol Cell Probes. 2017;32:40-45 pubmed publisher
    ..In addition, the promoter activity with Hap1 haplotype was higher than the Hap8 haplotype, consistent with the association analysis...
  6. Rodriguez Castaneda F, Lemma R, Cuervo I, Bengtsen M, Moen L, Ledsaak M, et al. The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression. J Biol Chem. 2018;293:15439-15454 pubmed publisher
    ..we validated and mapped this interaction, and using CRISPR-Cas9-generated CHD3- and SENP1-KO cells (in the haploid HAP1 cell line), we investigated whether these two proteins are functionally linked in regulating chromatin remodeling ..
  7. González Almela E, Williams H, Sanz M, Carrasco L. The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells. Front Microbiol. 2018;9:207 pubmed publisher
    ..The finding of eIF4A and eIF4G in stress granules suggests that they do not participate in mRNA translation. Human HAP1 cells depleted for eIF2A, eIF2D, or both factors, were able to synthesize luciferase from an mRNA bearing the HCV ..
  8. Merhej J, Delaveau T, Guitard J, Palancade B, Hennequin C, Garcia M, et al. Yap7 is a transcriptional repressor of nitric oxide oxidase in yeasts, which arose from neofunctionalization after whole genome duplication. Mol Microbiol. 2015;96:951-72 pubmed publisher
    ..In S. cerevisiae, YHB1 repression also involves interaction of Yap7 with the Hap2/3/5 complex through a conserved Hap4-like-bZIP domain, but this interaction has been lost in C. glabrata...
  9. Ning J, Otto T, Pfander C, Schwach F, Brochet M, Bushell E, et al. Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates. Genes Dev. 2013;27:1198-215 pubmed publisher
    ..Our previous discovery that the broadly conserved protein HAP2 (GCS1) functioned in gamete membrane fusion in the unicellular green alga Chlamydomonas and the malaria pathogen ..
  10. Wu M, Gengenbacher M, Chung J, Chen S, Mollenkopf H, Kaufmann S, et al. Developmental transcriptome of resting cell formation in Mycobacterium smegmatis. BMC Genomics. 2016;17:837 pubmed
    ..compaction of chromosomes was accompanied by an increase of the transcript level of the DNA binding protein Hlp, an orthologue of the Streptomyces spore-specific chromosome condensation protein HupS...
  11. Sanz M, González Almela E, Garcia Moreno M, Marina A, Carrasco L. A VIRAL RNA MOTIF INVOLVED IN SIGNALLING THE INITIATION OF TRANSLATION ON NON-AUG CODONS. RNA. 2019;: pubmed publisher
    ..This virus could also infect the human haploid cell line HAP1 and the double knock-out variant that lacks eIF2A and eIF2D...
  12. Shu Y, Liu Y, Li W, Song L, Zhang J, Guo C. Genome-Wide Investigation of MicroRNAs and Their Targets in Response to Freezing Stress in Medicago sativa L., Based on High-Throughput Sequencing. G3 (Bethesda). 2016;6:755-65 pubmed publisher
    ..nodulation were also identified, for example, the relationship between miR169 and the TF CCAAT (also named as NF-YA/HAP2), which suggested that nodulation has an important function in freezing tolerance in alfalfa...
  13. Shin J, Aftab Q, Austin P, McQueen J, Poon T, Li S, et al. Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech. 2016;9:1039-49 pubmed publisher
    ..Loss of either complex inhibited growth of Hap1 cells at neutral pH and caused sensitivity to acid stress, indicating that AP-3 and PAN complexes are promising new ..
  14. Recino A, Gan S, Sia K, Sawyer Y, Trendell J, Kay R, et al. Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2019;26:40-56 pubmed publisher
    ..transfer of NOD mouse AAV2/8-reactive serum to recipients prevented successful restoration of euglycaemia in AAV2/8-HLP-hINSco-treated NODscid mice...
  15. Wilcox L, Balderes D, Wharton B, Tinkelenberg A, Rao G, Sturley S. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem. 2002;277:32466-72 pubmed
    ..Two congenic upc2-1 strains, differing quantitatively in aerobic sterol uptake due to a modifying mutation in the HAP1 transcription factor, were compared using DNA microarrays...
  16. Geng X, Liu L, BANES BERCELI A, Yang Z, Kang P, Shen J, et al. Role of ZIP8 in regulating cell morphology and NF-κB/Snail2 signaling. Metallomics. 2018;10:953-964 pubmed publisher
    ..In ZIP8 knockout chronic myelogenous leukemia HAP1 cells, significant clonal morphological change with increased cell-cell adhesion was observed...
  17. Caussy C, Charrière S, Meirhaeghe A, Dallongeville J, Lefai E, Rome S, et al. Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter. Atherosclerosis. 2016;246:280-6 pubmed publisher
    ..Bio-informatic studies identified several putative miRNA binding-sites on the wild-type Hap1 haplotype, lost on Hap4...
  18. Hu Y, Liu Y, Hao X, Wang D, Akhberdi O, Xiang B, et al. Regulation of the Gα-cAMP/PKA signaling pathway in cellulose utilization of Chaetomium globosum. Microb Cell Fact. 2018;17:160 pubmed publisher
    ..the expression of transcription factors was also found to be regulated by gna1, especially Ace1, Clr1/2 and Hap2/3/5 complex...
  19. Menezes de Carvalho N, Palacios Gimenez O, Milani D, Cabral de Mello D. High similarity of U2 snDNA sequence between A and B chromosomes in the grasshopper Abracris flavolineata. Mol Genet Genomics. 2015;290:1787-92 pubmed publisher
    ..e., Hap1) being highly prevalent and putatively ancestral...
  20. Marinova Z, Maercker A, Grunblatt E, Wojdacz T, Walitza S. A pilot investigation on DNA methylation modifications associated with complex posttraumatic symptoms in elderly traumatized in childhood. BMC Res Notes. 2017;10:752 pubmed publisher
    ..Differentially methylated CpG sites were mapped to the genes huntington associated protein 1 (HAP1), RAN binding protein 2 (RANBP2) and proteasome subunit alpha 4 (PSMA4), respectively...
  21. Raza S, Khan R, Schreurs N, Guo H, Gui L, Mei C, et al. Expression of the bovine KLF6 gene polymorphisms and their association with carcass and body measures in Qinchuan cattle (Bos Taurus). Genomics. 2019;: pubmed publisher
    ..05) with larger body and carcass measurements. Association analysis results indicated that individuals with the Hap1/4 diplotype had a longer body and rump, were taller at the withers, and were wider at the hip than the other ..
  22. Sharma M, Redpath G, Williams M, McCormick S. Recycling of Apolipoprotein(a) After PlgRKT-Mediated Endocytosis of Lipoprotein(a). Circ Res. 2017;120:1091-1102 pubmed publisher
    ..Lp(a) internalization was reduced 0.35-fold in HAP1 and 0.33-fold in human hepatoma cells in which the plasminogen receptor (KT) was knocked out...
  23. Wei D, Gui L, Raza S, Zhang S, Khan R, Wang L, et al. NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Sci Rep. 2017;7:7867 pubmed publisher
    ..traits (BMTs) than the others, which was consistent with the results showing that the transcriptional activity of Hap2 was higher than the others in Qinchuan cattle myoblast cells...
  24. Sweeny E, Singh A, Chakravarti R, Martinez Guzman O, Saini A, Haque M, et al. Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. J Biol Chem. 2018;293:14557-14568 pubmed publisher
    ..including inducible nitric-oxide synthase (iNOS) in murine macrophages and the nuclear transcription factor Hap1 in yeast, even though this GAPDH variant caused cellular levels of labile heme to rise dramatically...
  25. Serratore N, Baker K, Macadlo L, Gress A, Powers B, Atallah N, et al. A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics. 2018;208:1037-1055 pubmed publisher
    ..mass spectrometry analysis revealed that Set4 interacts with the hypoxic-specific transcriptional repressor, Hap1, where this interaction is necessary for Set4 recruitment to ergosterol gene promoters under hypoxia...
  26. Speijer D, Lukes J, Elias M. Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life. Proc Natl Acad Sci U S A. 2015;112:8827-34 pubmed publisher
    ..extended searches for homologs of two proteins functioning in cell and nuclear fusion, respectively (HAP2 and GEX1), providing indirect evidence for these processes in several eukaryotic lineages where sex has not been ..
  27. Lee S, Song J, Bösl K, Müller A, Vitko D, Bennett K, et al. Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines. Proteomics. 2018;18:e1700386 pubmed publisher
    ..In this study, we performed expression proteomics of two near-haploid cell types such as HAP1 and KBM-7 to hunt for missing proteins...
  28. Zhang Z, Zhang G, Zhu F, Zhang D, Yuan S. The roles of tetrapyrroles in plastid retrograde signaling and tolerance to environmental stresses. Planta. 2015;242:1263-76 pubmed publisher
    ..The intermediate signaling components (such as PTM, HSP70-HSP90-HAP1 complex and PAPP5) between the nucleus and the plastid also positively regulate plant resistance to environmental ..
  29. Wang G, Maier R. Bacterial histone-like proteins: roles in stress resistance. Curr Genet. 2015;61:489-92 pubmed publisher
    ..A recent study reported a novel DNA-binding protein (HP119) in Helicobacter pylori that shows some HLP features. It plays a large role in aiding bacterial stress resistance...
  30. Wu Z, Xu M, Sheng H, Lou Y, Su X, Chen Y, et al. Association of natriuretic peptide polymorphisms with left ventricular dysfunction in southern Han Chinese coronary artery disease patients. Int J Clin Exp Pathol. 2014;7:7148-57 pubmed
    ..Subgroup analyses performed by hyperlipidemia (HLP) demonstrated 3 polymorphisms, rs632793 (OR = 0.31, 95% CI 0.1-0.93, P = 0.04), rs198388 (OR = 0.26, 95% CI 0.09-0...
  31. Zhang S, Yue X, Jiang F, Wang H, Liu B. Identification of an MITF gene and its polymorphisms associated with the Vibrio resistance trait in the clam Meretrix petechialis. Fish Shellfish Immunol. 2017;68:466-473 pubmed publisher
    ..Four SNPs (SNP2, 5, 6 and 13) and one haplotype (Hap1) were further confirmed to be associated with Vibrio resistance in M...
  32. Weiss K, Littleton J. Characterization of axonal transport defects in Drosophila Huntingtin mutants. J Neurogenet. 2016;30:212-221 pubmed
    ..Expression of dHtt in a milton (HAP1) mutant background revealed that the protein does not require mitochondria or HAP1 to localize along axons, ..
  33. Zahran E, Manning B, Seo J, Noga E. The effect of Ochratoxin A on antimicrobial polypeptide expression and resistance to water mold infection in channel catfish (Ictalurus punctatus). Fish Shellfish Immunol. 2016;57:60-67 pubmed publisher
    ..In this study, fish were fed 2, 4, or 8 mg OA/kg diet. Skin antibacterial activity and HLP-1 levels were measured on Days 0, 28 and 56...
  34. Martinelli F, Cannarozzi G, Balan B, Siegrist F, Weichert A, Blösch R, et al. Identification of miRNAs linked with the drought response of tef [Eragrostis tef (Zucc.) Trotter]. J Plant Physiol. 2018;224-225:163-172 pubmed publisher
    ..Among the targets were transcription factors such as CCAAT-HAP2, MADS and NAC...
  35. Kim Y, Jung H, Park J, Hur Y, Nou I. Response of NBS encoding resistance genes linked to both heat and fungal stress in Brassica oleracea. Plant Physiol Biochem. 2015;86:130-6 pubmed publisher
    ..to be complete and incomplete members of the TIR-NBS-LRR (TNL) class families, and another identified as an NFYA-HAP2 family member...
  36. Riemersma M, Sandrock J, Boltje T, Büll C, Heise T, Ashikov A, et al. Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal α-dystroglycan O-mannosylation, independent from sialic acid. Hum Mol Genet. 2015;24:2241-6 pubmed publisher
    ..Removal of sialic acids from HAP1 wild-type cells after incorporation or preventing sialylation during synthesis did not affect α-DG O-..
  37. Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, et al. The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem. 2017;292:15538-15551 pubmed publisher
    ..Disruption of HACD2 in the haploid human cell line HAP1 significantly reduced FA elongation activities toward both saturated and unsaturated FAs, and HACD1 HACD2 ..
  38. Valansi C, Moi D, Leikina E, Matveev E, Graña M, Chernomordik L, et al. Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens. J Cell Biol. 2017;216:571-581 pubmed publisher
    Cell-cell fusion is inherent to sexual reproduction. Loss of HAPLESS 2/GENERATIVE CELL SPECIFIC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear...
  39. Lim Y, Wu L, Chen S, Sun Y, Vijayaraj S, Yang M, et al. HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons. Mol Neurobiol. 2018;55:1815-1830 pubmed publisher
    ..Huntingtin-associated protein 1 (HAP1) is involved in trafficking of vesicles intracellularly and also interacts with several membrane proteins including ..
  40. Sanz M, González Almela E, Carrasco L. Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D. Sci Rep. 2017;7:43876 pubmed publisher
    ..Several studies have suggested that eIF2 can be replaced by eIF2A or eIF2D. HAP1 human cell lines knocked-out for eIF2A, eIF2D or both by CRISPR/Cas9 genome engineering were compared with wild-..
  41. Teixeira F, Manfiolli A, Vieira N, Medeiros A, Coelho P, Santiago Guimarães D, et al. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation. Arch Biochem Biophys. 2017;621:38-45 pubmed publisher
    ..We show that induction of FBXO25 reduced ERK1/2 phosphorylation independently of MEK1/2. Accordingly, in HAP1 FBXO25 knockout cells (FBXO25KO), we observed that upon PMA treatment ERK1/2 was more active than in ..
  42. Lonie J, Tsingos Lucas C. The use of Eriksonian Hypnosis to improve patient outcomes in pharmacy practice: A novel communication skill for pharmacists. Res Social Adm Pharm. 2017;13:1181-1183 pubmed publisher
    ..With the appropriate training, Eriksonian Hypnosis or the use of techniques such as hypnotic language patterns (HLP) have the potential to be implemented into pharmacy practice settings and assist those patients who have previously ..
  43. Zhang H, Wu H, Huang H, Xiao Y, Wang D. [Effects of electroacupuncture stimulation of "Fenglong" (ST 40) on expression of liver ATP-binding cassette transporter A 1 mRNA and protein in rats with hyperlipidemia]. Zhen Ci Yan Jiu. 2013;38:100-5 pubmed
    ..electroacupuncture (EA) at "Fenglong" (ST 40) on blood lipid levels and hepatic ATP binding cassette transporter A 1(ABCA 1) mRNA and protein expression in hyperlipidemia rats, so as to study its mechanism underlying improvement of HLP.
  44. Santos C, Turiel S, Sousa Gomes P, Costa E, Santos Silva A, Quadros P, et al. Vascular biosafety of commercial hydroxyapatite particles: discrepancy between blood compatibility assays and endothelial cell behavior. J Nanobiotechnology. 2018;16:27 pubmed publisher
    ..e. rod-like, nano dimensions and low aspect ratio (HAp1) and needle-shape with wider size and aspect ratio (HAp2)...
  45. Kim S, Cho H, Baek S. Effects of Healthy Life Practice Education on Reported Health Behaviors Among Fourth-Grade Elementary School Students in South Korea. J Sch Nurs. 2016;32:397-406 pubmed
    The purpose of this study was to test the effects of healthy life practice (HLP) education on reported health behaviors, including health promotion, disease prevention, and safety among fourth-grade elementary school students...
  46. Vadiveloo A, Moheimani N, Alghamedi R, Cosgrove J, Alameh K, Parlevliet D. Sustainable cultivation of microalgae by an insulated glazed glass plate photobioreactor. Biotechnol J. 2016;11:363-74 pubmed publisher
    ..MUR 267) in the IGP was compared against conventional flat plate photobioreactors subjected to the full spectrum (HLP) and also externally modified spectrum (CLP) of halogen lights...
  47. Zhang Y, Zhou X, Ji L, Du X, Sang Q, Chen F. Enzymatic single-step preparation and antioxidant activity of hetero-chitooligosaccharides using non-pretreated housefly larvae powder. Carbohydr Polym. 2017;172:113-119 pubmed publisher
    ..LZ32 was isolated. Non-pretreated Housefly larvae powder (HLP) was used as an adsorbent to purify chitinolytic enzymes...
  48. Hymøller L, Jensen S. Plasma transport of ergocalciferol and cholecalciferol and their 25-hydroxylated metabolites in dairy cows. Domest Anim Endocrinol. 2017;59:44-52 pubmed publisher
    ..weekly and plasma fractionated by ultracentrifugation into 3 fractions: light lipoprotein (LLP), heavy lipoprotein (HLP), and protein and analyzed for content of ERG and CHO and their liver derived metabolites 25-hydroxyergocalciferol (..
  49. Cilano K, Mazanek Z, Khan M, Metcalfe S, Zhang X. A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana. PLoS ONE. 2016;11:e0148200 pubmed publisher
    ..A new mutation, hap1-2. leads to premature pollen death and a reduced seed production in Arabidopsis...
  50. Li S, Wu N, Zhu C, Zhang Y, Guo Y, Gao Y, et al. Significance of lipoprotein(a) levels in familial hypercholesterolemia and coronary artery disease. Atherosclerosis. 2017;260:67-74 pubmed publisher
    ..possible, definite/probable FH) independent of the patients status, with Lp(a)-hyperlipoproteinemia [Lp(a)-HLP] (median 517.70 vs. 570.98 vs. 604.65 mg/L, p < 0.001) or without (median 89.20 vs. 99.20 vs. 133...
  51. Pan H, Yang Q, Huang G, Ding C, Cao P, Huang L, et al. Hypolipidemic effects of chitosan and its derivatives in hyperlipidemic rats induced by a high-fat diet. Food Nutr Res. 2016;60:31137 pubmed publisher
    Hyperlipidemia (HLP) is the primary risk factor of cardiovascular disease (CVD). Various factors, including genetics, physical inactivity, and daily nutritional habits, affect the prevalence of HLP...
  52. Yang N, Zhang D, Hao J. Coagulopathy and the prognostic potential of D-dimer in hyperlipidemia-induced acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2015;14:633-41 pubmed
    ..Based on disease etiology, there were 31 HL-induced AP (HLP) cases and 75 NHL-induced AP (NHLP) cases...
  53. Roeseler E, Julius U, Heigl F, Spitthoever R, Heutling D, Breitenberger P, et al. Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease: Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization. Arterioscler Thromb Vasc Biol. 2016;36:2019-27 pubmed publisher
    Lipoprotein(a)-hyperlipoproteinemia (Lp(a)-HLP) along with progressive cardiovascular disease has been approved as indication for regular lipoprotein apheresis (LA) in Germany since 2008...
  54. Manca M, Pessoa V, Lopez A, Harrison P, Miyajima F, Sharp H, et al. The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats. J Mol Neurosci. 2018;64:459-470 pubmed publisher
    ..Through expression analysis in semi-haploid HAP1 cell lines genetically engineered in order to knockout (KO) either the uVNTR, dVNTR, or both VNTRs, we assessed the ..
  55. Theodosiou G, Papageorgiou M, Vakirlis E, Mandekou Lefaki I. Successful treatment of hypertrophic lichen planus with betamethasone under occlusion and TCA-peelings. Dermatol Ther. 2016;29:338-340 pubmed publisher
    Hypertrophic lichen planus (HLP) is a variant of lichen planus characterized by marked epidermal hyperplasia and severe pruritus...
  56. Zhou J, Jin J, Li X, Zhao Z, Zhang L, Wang Q, et al. Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats. Urolithiasis. 2018;46:231-241 pubmed publisher
    ..Animal models of CaOx urolithiasis were established in male Sprague-Dawley rats by adding 5% w/w hydroxy-L-proline (HLP) in regular rat chow...
  57. Ding Q, Zeng J, He X. MiR169 and its target PagHAP2-6 regulated by ABA are involved in poplar cambium dormancy. J Plant Physiol. 2016;198:1-9 pubmed publisher
    ..The yeast functional complementation analysis showed that PagHAP2-6 was a homolog of Heme Activator Protein2 (HAP2)/Nuclear factor Y-A (NF-YA) transcription factor in poplar...
  58. Kenny M, Mendez F, Sandigursky M, Kureekattil R, Goldman J, Franklin W, et al. Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites. J Biol Chem. 2001;276:9532-6 pubmed
    The interaction of human heat shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coimmunoprecipitation...
  59. Liu R, Moss B. Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. J Virol. 2016;90:7864-79 pubmed publisher
    ..Human HAP1 and A549 cells were genetically modified by clustered regularly interspaced short palindromic repeat-Cas9 (CRISPR-..
  60. Carter J, Hussain S. Robust long-read native DNA sequencing using the ONT CsgG Nanopore system. Wellcome Open Res. 2017;2:23 pubmed publisher
    ..on ONTs miniature 'MinION' device and sequenced native genomic DNA obtained from the near haploid cancer cell line HAP1. Analysis of our data was performed utilising recently described computational tools tailored for nanopore/long-..
  61. Gutekunst C, Li S, Yi H, Ferrante R, Li X, Hersch S. The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. J Neurosci. 1998;18:7674-86 pubmed
    The cellular and subcellular distribution of HAP1 was examined in rat brain by light and electron microscopic immunocytochemistry and subcellular fractionation...
  62. Nasir J, MacLean A, Engelender S, Duan K, Margolis R, Kleiderlein J, et al. Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping. Mamm Genome. 1999;10:397-8 pubmed
  63. Li Y, Chin L, Levey A, Li L. Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem. 2002;277:28212-21 pubmed
    Huntingtin-associated protein 1 (HAP1) is a novel protein of unknown function with a higher binding affinity for the mutant form of Huntington's disease protein huntingtin...
  64. Cornett J, Cao F, Wang C, Ross C, Bates G, Li S, et al. Polyglutamine expansion of huntingtin impairs its nuclear export. Nat Genet. 2005;37:198-204 pubmed
    ..These results suggest that Tpr has a role in the nuclear export of N-terminal htt and that polyQ expansion reduces this nuclear export to cause the nuclear accumulation of htt. ..
  65. Takeshita Y, Fujinaga R, Kokubu K, Islam M, Jahan M, Yanai A, et al. Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain. Neuroreport. 2011;22:232-8 pubmed publisher
    Huntingtin-associated protein 1 (HAP1) is an essential component of the stigmoid body (STB) and known as a possible neuroprotective interactor with causative proteins for Huntington's disease, spinal and bulbar muscular atrophy, ..
  66. Wang W, Yan H, Zhang Q, Song W, Li H, Xu J. Evaluating the association of polymorphisms in the HAP1 gene with lung cancer risk: a meta-analysis. Tumour Biol. 2014;35:10825-31 pubmed publisher
    Studies on the relationship of HAP1 polymorphisms (-141 T > G; 1349 T > G) and lung cancer risk to date indicated controversial results. This study was devised to clarify whether the polymorphisms predispose to lung cancer...
  67. Pan J, Yuan S, Yu T, Su C, Liu X, He J, et al. Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1. J Biol Chem. 2016;291:26352-26363 pubmed
    Huntingtin-associated protein 1 (Hap1) was originally identified as a protein that binds to the Huntington disease protein, huntingtin...
  68. Olbrich T, Mayor Ruiz C, Vega Sendino M, Gomez C, Ortega S, Ruiz S, et al. A p53-dependent response limits the viability of mammalian haploid cells. Proc Natl Acad Sci U S A. 2017;114:9367-9372 pubmed publisher
    ..lines include near-haploid human cell lines isolated from a patient with chronic myelogenous leukemia (KBM7 and HAP1), as well as haploid embryonic stem cells derived from several organisms...
  69. Zhang T, Bu P, Zeng J, Vancura A. Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression. J Biol Chem. 2017;292:16942-16954 pubmed publisher
    ..We found that heme induces transcription of HAP4, the transcriptional activation subunit of the Hap2/3/4/5p complex, required for growth on nonfermentable carbon sources, in a Hap1p- and Hap2/3/4/5p-dependent manner...
  70. Poller W, Berger A, Dreger H, Morgera S, Enke Melzer K. Lipoprotein apheresis in patients with peripheral artery disease and lipoprotein(a)-hyperlipoproteinemia: 2-year follow-up of a prospective single center study. Atheroscler Suppl. 2017;30:174-179 pubmed publisher
    Elevated plasma levels of lipoprotein(a) [Lp(a)], referred to as lipoprotein(a)-hyperlipoproteinemia [Lp(a)-HLP], are an independent risk factor for atherosclerosis...
  71. Nasir J, Lafuente M, Duan K, Colomer V, Engelender S, Ingersoll R, et al. Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism. Gene. 2000;254:181-7 pubmed
    ..The detailed characterisation of the genomic organisation of HAP-1 and the presence of an intragenic polymorphism will be helpful in evaluating its role in different disorders, using candidate gene approaches. ..
  72. Wu L, Fan Y, Li S, Li X, Zhou X. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem. 2010;285:5614-23 pubmed publisher
    ..Here, we report that Huntingtin-associated protein-1 (HAP1) interacts with the prodomain of BDNF and that the interaction was reduced in the presence of polyQ-expanded ..
  73. Taherzadeh Fard E, Saft C, Wieczorek S, Epplen J, Arning L. Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1. Neurogenetics. 2010;11:435-9 pubmed publisher
    ..variations in the genes encoding adenosinergic A(2A) receptor (ADORA2A), human huntingtin-associated protein-1 (HAP1) and the single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase (OGG1)...
  74. Zhu L, Song X, Tang J, Wu J, Ma R, Cao H, et al. Huntingtin-associated protein 1: a potential biomarker of breast cancer. Oncol Rep. 2013;29:1881-7 pubmed publisher
    ..In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues...
  75. Mackenzie K, Lumsden A, Guo F, Duffield M, Chataway T, Lim Y, et al. Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. J Neurochem. 2016;138:710-21 pubmed publisher
    Huntingtin-associated protein-1 (HAP1) is involved in intracellular trafficking, vesicle transport, and membrane receptor endocytosis...
  76. Haller P, Jäger B, Farhan S, Christ G, Schreiber W, Weidinger F, et al. Impact of age on short- and long-term mortality of patients with ST-elevation myocardial infarction in the VIENNA STEMI network. Wien Klin Wochenschr. 2018;130:172-181 pubmed publisher
    ..In contrast, the number of patients with a positive family history, smoking and hyperlipidemia (HLP) significantly declined...
  77. Jaturakan O, Buranakarl C, Dissayabutra T, Chaiyabutr N, Kijtawornrat A, Rungsipipat A. Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model. J Vet Med Sci. 2017;79:1861-1869 pubmed publisher
    ..Hyperoxaluria was induced by feeding 2% (w/v) Hydroxy-L-proline (HLP) in the drinking water for 21 days...
  78. Hussein H, Bastos R, Schneider D, Johnson W, Adham F, Davis W, et al. The Babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction. PLoS Negl Trop Dis. 2017;11:e0005965 pubmed publisher
    ..Expression of HAP2 has been recognized as critical for the fertilization of parasites in the Babesia-related Plasmodium, and is a ..
  79. Camacho Nuez M, Hernández Silva D, Castañeda Ortiz E, Paredes Martínez M, Rocha Martínez M, Alvarez Sánchez M, et al. Hap2, a novel gene in Babesia bigemina is expressed in tick stages, and specific antibodies block zygote formation. Parasit Vectors. 2017;10:568 pubmed publisher
    ..b>HAP2/GCS1 is a protein identified in plants, protozoan parasites and other organisms that has an important role during ..
  80. Wu C, Kraft P, Zhai K, Chang J, Wang Z, Li Y, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet. 2012;44:1090-7 pubmed publisher
    ..Our results underscore the direct genetic contribution to ESCC risk, as well as the genetic contribution to ESCC through interaction with alcohol consumption. ..
  81. Tuz K, Hsiao Y, Juárez O, Shi B, Harmon E, Phelps I, et al. The Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions. J Biol Chem. 2013;288:13676-94 pubmed publisher
    ..Mutations in AHI1 decrease cilia formation, alter its localization and stability, and change its binding to HAP1 and NPHP1. Mutations in AHI1 affect ciliogenesis, AHI1 protein localization, and AHI1-protein interactions...
  82. Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A. 2017;114:E1224-E1233 pubmed publisher
    Huntingtin-associated protein 1 (Hap1) is known to be critical for postnatal hypothalamic function and growth...
  83. Tanaka A, Tumkosit U, Nakamura S, Motooka D, Kishishita N, Priengprom T, et al. Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection. J Virol. 2017;91: pubmed publisher
    ..In this study, we analyzed the host factors involved in CHIKV infection using genome-wide screening. Human haploid HAP1 cells, into which an exon-trapping vector was introduced, were challenged with a vesicular stomatitis virus ..
  84. He J, Carroll J, Ding S, Fearnley I, Walker J. Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase. Proc Natl Acad Sci U S A. 2017;114:9086-9091 pubmed publisher
    ..We investigated the possible involvement of the subunit b and the OSCP in the PTP by generating clonal cells, HAP1-Δb and HAP1-ΔOSCP, lacking the membrane domain of subunit b or the OSCP, respectively, in which the corresponding ..
  85. Takahashi T, Honda K, Mori T, Igawa T. Loss of GCS1/HAP2 does not affect the ovule-targeting behavior of pollen tubes. Plant Reprod. 2017;30:147-152 pubmed publisher
    KEY MESSAGE : hap2-1 pollen tube ovule targeting. Upon pollination, a pollen grain germinates to produce a pollen tube, which grows through the style to deliver two immobile sperm cells to the female gametophyte...
  86. David S, Correia V, Antunes L, Faria R, Ferrão J, Faustino P, et al. Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity. Immunogenetics. 2018;70:169-177 pubmed publisher
    ..Conversely, although with borderline significance, haplotype Hap1 with rs34481144-G, not including rs12252-C, was associated to severe disease...
  87. Rodriguez G, Bowen J, Grossin D, Ben Nissan B, Stamboulis A. Functionalisation of Ti6Al4V and hydroxyapatite surfaces with combined peptides based on KKLPDA and EEEEEEEE peptides. Colloids Surf B Biointerfaces. 2017;160:154-160 pubmed publisher
    ..The modifications involved the inclusion of a glycine spacer between the binding terminals (Ti-Hap2) and the addition of a second titanium binder (KKLPDA) (Ti-Hap3 and Ti-Hap4)...
  88. Ceska R. [Hyperlipoprotienemias and (not only) atherosclerosis: fragments from history and present]. Cas Lek Cesk. 2017;156:303-307 pubmed
    ..the recent view, clearly demonstrate a great change in the perception of hyperlipoprotienemias and dyslipidemias (HLP and DLP) at the end of 20th and at the beginning of 21st century...
  89. Li S, Hosseini S, Gutekunst C, Hersch S, Ferrante R, Li X. A human HAP1 homologue. Cloning, expression, and interaction with huntingtin. J Biol Chem. 1998;273:19220-7 pubmed
    ..We previously identified a rat huntingtin-associated protein (HAP1) that binds to huntingtin; HAP1 binds more tightly to huntingtin with an expanded glutamine repeat than to wild ..
  90. Li S, Gutekunst C, Hersch S, Li X. Association of HAP1 isoforms with a unique cytoplasmic structure. J Neurochem. 1998;71:2178-85 pubmed
    b>HAP1 is a neural protein and interacts with the Huntington's disease protein huntingtin. There are at least two HAP1 isoforms, HAP1-A and HAP1-B, which have different C-terminal amino acid sequences...
  91. Luke M, Kane J, Liu D, Rowland C, Shiffman D, Cassano J, et al. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol. 2007;27:2030-6 pubmed
    ..Testing these 302 SNPs in Study 2 (471 cases, 298 controls), we found 5 (in LPA, CALM1, HAP1, AP3B1, and ABCG2) were nominally associated with severe CAD and had the same risk alleles in both studies...
  92. Metzger S, Rong J, Nguyen H, Cape A, Tomiuk J, Soehn A, et al. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol Genet. 2008;17:1137-46 pubmed publisher
    ..interacting proteins might contribute to this variation in the AAO and investigated human htt-associated protein-1 (HAP1) using genetic and functional assays...