Gene Symbol: HAND1
Description: heart and neural crest derivatives expressed 1
Alias: Hxt, Thing1, bHLHa27, eHand, heart- and neural crest derivatives-expressed protein 1, class A basic helix-loop-helix protein 27, extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
Species: human
Products:     HAND1

Top Publications

  1. Reamon Buettner S, Ciribilli Y, Inga A, Borlak J. A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet. 2008;17:1397-405 pubmed publisher
    ..but the basic helix-loop-helix (bHLH) transcription factor heart and neural crest derivatives expressed 1 (Hand1), may be a candidate culprit for this condition...
  2. Reamon Buettner S, Ciribilli Y, Traverso I, Kuhls B, Inga A, Borlak J. A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Hum Mol Genet. 2009;18:3567-78 pubmed publisher
    Heart and neural crest derivatives expressed 1 (HAND1) is a basic helix-loop-helix (bHLH) transcription factor essential for mammalian heart development...
  3. Wang J, Lu Y, Chen H, Yin M, Yu T, Fu Q. Investigation of somatic NKX2-5, GATA4 and HAND1 mutations in patients with tetralogy of Fallot. Pathology. 2011;43:322-6 pubmed publisher
    ..We sequenced all exons and their boundaries of the NKX2-5, GATA4 and HAND1 genes from the right ventricular outflow tract muscle and peripheral blood of 38 unrelated non-syndromic TOF ..
  4. Esposito G, Butler T, Blue G, Cole A, Sholler G, Kirk E, et al. Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. Am J Med Genet A. 2011;155A:2416-21 pubmed
    ..Analysis of NKX2–5, GATA4, and HAND1 was performed from cardiac tissue of 24 HLH patients and three matched blood samples...
  5. Cheng Z, Lib L, Li Z, Liu M, Yan J, Wang B, et al. Two novel HAND1 mutations in Chinese patients with ventricular septal defect. Clin Chim Acta. 2012;413:675-7 pubmed publisher
    The HAND1 gene encodes a basic helix-loop-helix (bHLH) transcription factor which plays an essential role in the development of heart...
  6. Santos López J, Garcimartín A, Bastida S, Bautista Ávila M, González Muñoz M, Benedi J, et al. Lipoprotein Profile in Aged Rats Fed Chia Oil- or Hydroxytyrosol-Enriched Pork in High Cholesterol/High Saturated Fat Diets. Nutrients. 2018;10: pubmed publisher
    ..functional ingredients, like Chia oil (one of the richest natural source of α-linolenic acid) or hydroxytyrosol (HxT) (potent antioxidant), both with hypolipidemic activities, is one of the strategies that may help to reduce the ..
  7. O Donnell A, Schmidt M. AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking. Int J Mol Sci. 2019;20: pubmed publisher
    ..in glucose metabolism is glucose uptake, a process mediated by members of the GLUT/SLC2A (glucose transporters) or HXT (hexose transporters) family of twelve-transmembrane domain glucose transporters in mammals and yeast, respectively...
  8. Nobili V, Alisi A, Mosca A, Crudele A, Zaffina S, Denaro M, et al. The antioxidant effects of Hydroxytyrosol and Vitamin E on pediatric NAFLD, in a clinical trial: a new treatment?. Antioxid Redox Signal. 2018;: pubmed publisher
    ..of oxidative-stress parameters and liver ultrasound, and tolerability of a mixture of vitamin E and Hydroxytyrosol (HXT) in adolescents with biopsy-proven NAFLD...
  9. Ståhl T, Hümmer S, Ehrenfeuchter N, Mittal N, Fucile G, Spang A. Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast. EMBO J. 2019;: pubmed publisher
    ..Importantly, when cells were shifted from starvation to glucose-rich conditions, HXT2 mRNA, but none of the other HXT mRNAs, was enriched in the bud after MAT This enrichment was dependent on the Ras/cAMP/PKA pathway, the APC ..

More Information

Publications102 found, 100 shown here

  1. Yu D, Xie X, Qiao B, Ge W, Gong L, Luo D, et al. Gestational exposure to acrylamide inhibits mouse placental development in vivo. J Hazard Mater. 2019;367:160-170 pubmed publisher
    ..Expression levels of most placental key genes such as Esx1, Hand1, and Hand2 mRNA dramatically decreased in acrylamide-treated placentas...
  2. Zhu D, Fang J, Li Y, Zhang J. Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation. PLoS ONE. 2009;4:e7684 pubmed publisher
    ..Mbd3 knockdown cells show elevated RNA expression of trophectoderm markers, including Cdx2, Eomesodermin, and Hand1. In parallel, these cells show an increased acetylation level of histone 3 in promoters of the respective genes, ..
  3. Yuan F, Qiu Z, Wang X, Sun Y, Wang J, Li R, et al. MEF2C loss-of-function mutation associated with familial dilated cardiomyopathy. Clin Chem Lab Med. 2018;56:502-511 pubmed publisher
    ..Furthermore, the mutation abolished the synergistic transactivation between MEF2C and GATA4 as well as HAND1, two other transcription factors that have been associated with DCM...
  4. Scharff Poulsen P, Moriya H, Johnston M. Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae. G3 (Bethesda). 2018;8:2685-2696 pubmed publisher
    ..to glucose that leads to inhibition of the Rgt1 transcriptional repressor and consequently to derepression of HXT genes encoding glucose transporters...
  5. Roy A, Dement A, Cho K, Kim J. Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1). PLoS ONE. 2015;10:e0121985 pubmed publisher
    ..We find that 2-NBDG is not incorporated into the hxt null strain lacking all glucose transporter genes and that this defect is rescued by expression of wild type Hxt1, ..
  6. Díaz Hellín P, Naranjo V, Ubeda J, Briones A. Saccharomyces cerevisiae and metabolic activators: HXT3 gene expression and fructose/glucose discrepancy in sluggish fermentation conditions. World J Microbiol Biotechnol. 2016;32:196 pubmed
    ..Moreover, glucose and fructose are transported by the same hexose transporters (HXT), which present a greater affinity for glucose, so that late in fermentation, fructose becomes the predominant ..
  7. Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed publisher
    ..The transcription factor HAND1 emerges in metastatic disease, binds to established GIST-associated enhancers, and facilitates GIST cell ..
  8. Liu H, Xu Y, Li R, Wang Z, Zhang M, Qu X, et al. HAND2 loss-of-function mutation causes familial dilated cardiomyopathy. Eur J Med Genet. 2018;: pubmed publisher
    As two members of the basic helix-loop-helix family of transcription factors, HAND1 and HAND2 are both required for the embryonic cardiogenesis and postnatal ventricular structural remodeling...
  9. Bisson L, Fan Q, Walker G. Sugar and Glycerol Transport in Saccharomyces cerevisiae. Adv Exp Med Biol. 2016;892:125-168 pubmed publisher
    ..Members of the large family of hexose (HXT) transporters display uptake efficiencies consistent with their environmental expression and play physiological ..
  10. Beck Z, Cloutier S, Schipma M, Petell C, Ma W, Tran E. Regulation of glucose-dependent gene expression by the RNA helicase Dbp2 in Saccharomyces cerevisiae. Genetics. 2014;198:1001-14 pubmed publisher
    ..Further investigation revealed that both sense and antisense hexose transporter (HXT) transcripts are aberrantly expressed in DBP2-deficient cells and that this expression pathway can be partially ..
  11. Awaki H, Kunieda H, Ishida M, Matsumoto H, Babazaki Y, Demoto T, et al. Hard x-ray telescopes to be onboard ASTRO-H. Appl Opt. 2014;53:7664-76 pubmed publisher
    ..The HXT mirrors employ tightly nested, conically approximated thin-foil Wolter-I optics, and the mirror surfaces are coated ..
  12. Behr E, Savio Galimberti E, Barc J, Holst A, Petropoulou E, Prins B, et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015;106:520-9 pubmed publisher
    ..A multi-centre study sequenced seven candidate genes (SCN10A, HAND1, PLN, CASQ2, TKT, TBX3, and TBX5) in 156 Caucasian SCN5A mutation-negative BrS patients (80% male; mean age 48) ..
  13. Arnold D, Gaspar R, da Rocha C, Sangalli J, De Bem T, Corrêa C, et al. Nuclear transfer alters placental gene expression and associated histone modifications of the placental-specific imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2) in cattle. Reprod Fertil Dev. 2017;29:458-467 pubmed publisher
    ..05). Expression of heart and neural crest derivatives expressed 1 (HAND1), placental lactogen (PL), pregnancy-associated glycoprotein 9 (PAG-9) and PHLDA2 was elevated in NT cotyledons ..
  14. Chen C, Chu H, Chen C, Cheng Y, Tsai S, Chang M, et al. A safety comparative study between freezing nitrogen ethanol composite and liquid nitrogen for cryotherapy of musculoskeletal tumors. Cryobiology. 2018;83:34-39 pubmed publisher
    ..The evaluation of the radiant cooling damage was demonstrated human bone xenograft transplantation (HXT) in a mouse model...
  15. Jiang Y, Wang D, Zhang G, Wang G, Tong J, Chen T. Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene. Environ Toxicol. 2016;31:1372-1380 pubmed publisher
    ..5/Hand1 gene in cardiac progenitors and down regulation of the Mhc-7/cTnT gene in cardiac cells; and (3) significant ..
  16. Baghalishahi M, Efthekhar Vaghefi S, Piryaei A, Nematolahi Mahani S, Mollaei H, Sadeghi Y. Cardiac extracellular matrix hydrogel together with or without inducer cocktail improves human adipose tissue-derived stem cells differentiation into cardiomyocyte-like cells. Biochem Biophys Res Commun. 2018;502:215-225 pubmed publisher
    ..When hADSCs were cultured in the presence of cECM cardiac genes including GATA4, HAND1, HAND2, NKX2.5, Troponin I, βMHC, Connexin43 were highly expressed in differentiated cells...
  17. Meganathan K, Sotiriadou I, Natarajan K, Hescheler J, Sachinidis A. Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development. Int J Cardiol. 2015;183:117-28 pubmed publisher
    ..The expression of cardiac specific transcription factors, such as Gata4, Tbx5, Tbx20, Tbx2, Tbx3, Mef2c, Hey1 and Hand1 are of fundamental significance for the in-vivo cardiac development...
  18. Stasyk O, Denega I, Padhorny D, Dmytruk K, Kozakov D, Abbas C, et al. Glucose regulation in the methylotrophic yeast Hansenula (Ogataea) polymorpha is mediated by a putative transceptor Gcr1. Int J Biochem Cell Biol. 2018;103:25-34 pubmed publisher
    ..Heterologous expression of HpGcr1 in a Saccharomyces cerevisiae hxt-null strain did not restore glucose uptake due to protein mislocalization. However, HpGcr1 overexpression in H...
  19. Gancedo J, Flores C, Gancedo C. The repressor Rgt1 and the cAMP-dependent protein kinases control the expression of the SUC2 gene in Saccharomyces cerevisiae. Biochim Biophys Acta. 2015;1850:1362-7 pubmed publisher
    ..Rgt1 acts together with Mth1 to repress the HXT genes encoding glucose transporters, and the release of Rgt1 from some HXT promoters requires cAMP-dependent ..
  20. Ruane P, Berneau S, Koeck R, Watts J, Kimber S, Brison D, et al. Apposition to endometrial epithelial cells activates mouse blastocysts for implantation. Mol Hum Reprod. 2017;23:617-627 pubmed publisher
    ..05) and Gata3 (P < 0.05) and upregulation of the TGC transcription factor Hand1 (P < 0.05). Co-culture with non-endometrial human fibroblasts did not alter the expression of these genes. None...
  21. de Sales B, Scheid B, Gonçalves D, Knychala M, Matsushika A, Bon E, et al. Cloning novel sugar transporters from Scheffersomyces (Pichia) stipitis allowing D-xylose fermentation by recombinant Saccharomyces cerevisiae. Biotechnol Lett. 2015;37:1973-82 pubmed publisher
    ..An hxt-null S...
  22. Org T, Duan D, Ferrari R, Montel Hagen A, Van Handel B, Kerényi M, et al. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J. 2015;34:759-77 pubmed publisher
    ..to enhancers, Scl prevents ectopic cardiogenesis by occupying enhancers that cardiac factors, such as Gata4 and Hand1, use for gene activation...
  23. Hohenschuh W, HECTOR R, Murthy G. A dynamic flux balance model and bottleneck identification of glucose, xylose, xylulose co-fermentation in Saccharomyces cerevisiae. Bioresour Technol. 2015;188:153-60 pubmed publisher
    ..Further experiments showed xylulose transport through the HXT family of non-specific glucose transporters...
  24. Sui B, Huang J, Jha B, Yin P, Zhou M, Fu Z, et al. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol. 2016;97:880-6 pubmed publisher
    ..The structure displays a pair of strictly conserved HxT/Sx motifs and forms a deep, positively charged catalytic groove with ?-sheets and an arginine-containing loop...
  25. Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P. Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage. Stem Cell Res Ther. 2018;9:97 pubmed publisher
    ..This included genes like MYOF, NR2F2, NKX2.5, and HAND1 in cardiac progenitors and cardiomyocytes, and POU5F1 and NANOG in pluripotent hES cells...
  26. Martinez L, Ros G, Nieto G. Fe, Zn and Se Bioavailability in Chicken Meat Emulsions Enriched with Minerals, Hydroxytyrosol and Extra Virgin Olive Oil as Measured by Caco-2 Cell Model. Nutrients. 2018;10: pubmed publisher
    ..this work, Zn and Se bioavailability was increased in chicken meat emulsions that are enriched with Hydroxytyrosol (HXT), a phenolic compound obtained from olive leaf. Six different chicken emulsions were elaborated...
  27. Suasnavas E, Heywood S, Ward A, Cox L, O Grady M, Zhao Y, et al. Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos. Anim Reprod Sci. 2015;154:128-41 pubmed publisher
    ..of mRNA transcripts from genes involved in trophoblast function (CDX2, TEAD4, CYP17A1, HSD17B1, FGFR2, PLET, HAND1) as well as some genes known to mediate pluripotency (POU5F1, KLF4, CMYC)...
  28. Bagheri Hosseinabadi Z, Mesbah Namin S, Salehinejad P, Seyedi F. Fibrin scaffold could promote survival of the human adipose-derived stem cells during differentiation into cardiomyocyte-like cells. Cell Tissue Res. 2018;372:571-589 pubmed publisher
    ..5, Cx43, MLC2v, βMHC, HAND1, HAND2 and cTnI (P < 0.05) in the treated hADSCs with 50 μM 5-Aza in the 3D group...
  29. Hou D, Su M, Li X, Li Z, Yun T, Zhao Y, et al. The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632. PLoS ONE. 2015;10:e0142442 pubmed publisher
    ..The expression of TR lineage markers, such as CDX2, KRT7, KRT18, TEAD4, ELF5 and HAND1, imprinted genes such as IGF2, PEG1 and PEG10, and telomerase activity related genes TERC and TERF2 were detected ..
  30. Snowdon C, Johnston M. A novel role for yeast casein kinases in glucose sensing and signaling. Mol Biol Cell. 2016;27:3369-3375 pubmed
    ..SRR) pathway, which detects extracellular glucose and transmits an intracellular signal that induces expression of HXT genes. The yeast casein kinases (Ycks) are key players in this pathway...
  31. MacKenzie B, Wolff R, Lowe N, Billington C, Peterson A, Schmidt B, et al. Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol. 2009;328:13-23 pubmed publisher
    ..At E9.5, the distal region of the mutant BA1 was prematurely and variably fused with loss of distal markers eHand and Msx1. Expression of proximal markers Fgf8 and Barx1 was expanded across the fused BA1...
  32. Steenwyk J, Rokas A. Extensive Copy Number Variation in Fermentation-Related Genes Among Saccharomyces cerevisiae Wine Strains. G3 (Bethesda). 2017;7:1475-1485 pubmed publisher
    ..processes such as copper resistance (CUP), flocculation (FLO), and glucose metabolism (HXT), as well as the SNO gene family whose members are expressed before or during the diauxic shift, showed ..
  33. Balic A, Adams D, Mina M. Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009;238:2599-613 pubmed publisher
    ..and lateral regions were related to gradual loss of a subpopulation of mesenchyme in the medial region expressing eHand. Our analysis also showed that Prx gene products are required for the initiation and maintenance of chondrogenesis ..
  34. Sántos López J, Garcimartín A, Merino P, López Oliva M, Bastida S, Benedi J, et al. Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets. PLoS ONE. 2016;11:e0147469 pubmed publisher
    ..This study was designed to evaluate the effects of Si vs hydroxytyrosol (HxT) RP on liver antioxidant defense in aged rats fed cholesterol-enriched high saturated/high cholesterol diets as a ..
  35. Jo B, Koh I, Bae J, Yu H, Jeon E, Lee H, et al. Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy. Genomics. 2016;108:84-92 pubmed publisher
    ..Alterations in DNA methylation were specifically enriched in the cis-regulatory regions of cardiac development genes, the majority of which are involved in ventricular development (e.g., TBX5 and HAND1).
  36. Martínez L, Ros G, Nieto G. Hydroxytyrosol: Health Benefits and Use as Functional Ingredient in Meat. Medicines (Basel). 2018;5: pubmed publisher
    Hydroxytyrosol (HXT) is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil...
  37. Laurie L, Kokubo H, Nakamura M, Saga Y, Funato N. The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification. PLoS ONE. 2016;11:e0150263 pubmed publisher
    ..Here, we report that the basic helix-loop-helix transcription factor Hand1, which is expressed in the cartilage primordia, is involved in proper osteogenesis of the bone collar via its ..
  38. Zhang X, Wang J, Wang B, Chen S, Fu Q, Sun K. A Novel Missense Mutation of GATA4 in a Chinese Family with Congenital Heart Disease. PLoS ONE. 2016;11:e0158904 pubmed publisher
    ..Many GATA4 mutations have been identified in patients with different types of CHD. In this study, the NKX2-5, HAND1 and GATA4 coding regions were sequenced in a family spanning three generations in which seven patients had CHD...
  39. Vincentz J, Casasnovas J, Barnes R, Que J, Clouthier D, Wang J, et al. Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016;113:7563-8 pubmed publisher
    ..show that the distal-most of these subdomains, the distal cap, is marked by expression of the transcription factor Hand1 (H1) and gives rise to the ectomesenchymal derivatives of the lower incisors...
  40. Durbin M, Cadar A, Williams C, Guo Y, Bichell D, Su Y, et al. Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Pediatr Cardiol. 2017;38:1232-1240 pubmed publisher
    ..HLHS) has been associated with germline mutations in 12 candidate genes and a recurrent somatic mutation in HAND1 gene...
  41. Uesono Y, Toh e A, Kikuchi Y, Araki T, Hachiya T, Watanabe C, et al. Local Anesthetics and Antipsychotic Phenothiazines Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in Yeast. Genetics. 2016;202:997-1012 pubmed publisher
    ..In hxt(0) strains with all hexose transporter (HXT) genes deleted, a strain harboring a single copy of HXT1 (HXT1s) was ..
  42. Marugán Hernández V, Fiddy R, Nurse Francis J, Smith O, Pritchard L, Tomley F. Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella. Parasit Vectors. 2017;10:491 pubmed publisher
    ..tenella MCPs. Variants of the previously described HxT motif were analysed showing that HxT and VxT variants bind, whereas HxS and YxE variants did not...
  43. Estarás C, Hsu H, Huang L, Jones K. YAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineage. Genes Dev. 2017;31:2250-2263 pubmed publisher
    ..exposure of YAP-/- hESCs to Activin induces cardiac mesoderm markers (BAF60c and HAND1) without activating Wnt-dependent cardiac inhibitor genes (CDX2 and MSX1)...
  44. Sarkar A, Sabatino J, Sugrue K, Zohn I. Abnormal labyrinthine zone in the Hectd1-null placenta. Placenta. 2016;38:16-23 pubmed publisher
    ..trophoblast cell types reveals increased Dlx3 positive cells and Syna positive SynT-I cells, along with decreased Hand1 and Ctsq positive sinusoidal trophoblast giant cells (S-TGCs)...
  45. Liu Y, Mi Y, Zhang J, Li Q, Chen L. Illumina-based transcriptomic profiling of Panax notoginseng in response to arsenic stress. Bot Stud. 2016;57:13 pubmed publisher
    ..nitrate), genes related to hormone metabolism (ethylene, ABA, cytokinin) and genes related to arsenic accumulation (HXT, NRAMP, MT and GRX) were differentially expressed...
  46. Kim D, Song J, Hahn J. Improvement of glucose uptake rate and production of target chemicals by overexpressing hexose transporters and transcriptional activator Gcr1 in Saccharomyces cerevisiae. Appl Environ Microbiol. 2015;81:8392-401 pubmed publisher
    ..Deletion of STD1 and MTH1, encoding corepressors of HXT genes, exerted differential effects on the glucose uptake rate, depending on the culture conditions...
  47. Ochi H, Suzuki N, Kawaguchi A, Ogino H. Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element. Dev Biol. 2017;425:152-160 pubmed publisher
    ..Therefore, we investigated this process by analyzing the duplicated hand1 genes of Xenopus laevis (hand1.L and hand1...
  48. Tam J, Ko C, Koon C, Cheng Z, Lok W, Lau C, et al. Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula. PLoS ONE. 2015;10:e0139342 pubmed publisher
    ..DNAJB7 in protein translation; BIRC5, EPCAM, INSL4, MMP8 and NPR3 in cell proliferation; CXCR7, EPCAM, HAND1 and MMP8 in migration; CXCR7, EPCAM and MMP8 in tubular formation; and BIRC5, CXCR7, EPCAM, HAND1, MMP8 and UBD in ..
  49. Lazar Z, Neuvéglise C, Rossignol T, Devillers H, Morin N, Robak M, et al. Characterization of hexose transporters in Yarrowia lipolytica reveals new groups of Sugar Porters involved in yeast growth. Fungal Genet Biol. 2017;100:1-12 pubmed publisher
    ..cerevisiae, and for two decades, it has been clear that the homologous HXT genes, which encode a set of hexose transporters, play a central role in this process...
  50. Ceccaroli P, Saltarelli R, Polidori E, Barbieri E, Guescini M, Ciacci C, et al. Sugar transporters in the black truffle Tuber melanosporum: from gene prediction to functional characterization. Fungal Genet Biol. 2015;81:52-61 pubmed publisher
    ..The heterologous expression of Tmelhxt1 and Tmel2281 in an hxt-null Saccharomyces cerevisiae strain restores the growth in glucose and fructose...
  51. Nagahori H, Suzuki N, Le Coz F, Omori T, Saito K. Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates. Toxicol Lett. 2016;259:44-51 pubmed publisher
    b>Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST) is a promising alternative method for evaluation of developmental toxicity...
  52. Scott I, Anson Cartwright L, Riley P, Reda D, Cross J. The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol. 2000;20:530-41 pubmed
    The basic helix-loop-helix (bHLH) transcription factor genes Hand1 and Mash2 are essential for placental development in mice...
  53. Knöfler M, Meinhardt G, Bauer S, Loregger T, Vasicek R, Bloor D, et al. Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem J. 2002;361:641-51 pubmed
    The basic helix-loop-helix (bHLH) transcription factor, Hand1, plays an important role in the development of the murine extra-embryonic trophoblast cell lineage...
  54. Asuthkar S, Guda M, Martin S, Antony R, Fernandez K, Lin J, et al. Hand1 overexpression inhibits medulloblastoma metastasis. Biochem Biophys Res Commun. 2016;477:215-21 pubmed publisher
    ..that uPAR protein act as cytoplasmic sequestration factor for a novel basic helix-loop-helix transcription factor, Hand1. Among the histological subtypes classical and desmoplastic subtypes account for the majority while large cell/..
  55. Li X, Li Z, Hou D, Zhao Y, Wang C, Li X. The bovine endometrial epithelial cells promote the differentiation of trophoblast stem-like cells to binucleate trophoblast cells. Cytotechnology. 2016;68:2687-2698 pubmed
    ..level of KRT18 was down-regulated while the expression level of trophoblast differentiation marker MASH2, HAND1, GCM1 and CDX2 was up-regulated in bTS cells...
  56. Dai Y, Cserjesi P. The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J Biol Chem. 2002;277:12604-12 pubmed
    ..We conclude that HAND2 functions as a transcription activator by binding a subset of E-boxes as a heterodimer with E-proteins. ..
  57. Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M. MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem. 2005;280:32272-8 pubmed
    ..Within the embryo, HAND1 is first detected in the developing heart where it becomes restricted to the atrial and left ventricular ..
  58. Zhou Y, Dai X, Qiu X, Yuan F, Li R, Xu Y, et al. HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy. Clin Chem Lab Med. 2016;54:1161-7 pubmed publisher
    The basic helix-loop-helix transcription factor HAND1 is essential for cardiac development and structural remodeling, and mutations in HAND1 have been causally linked to various congenital heart diseases...
  59. Jung K, McCarthy R, Zhou C, Uprety N, Barton M, Beretta L. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 2016;34:1284-96 pubmed publisher
    ..accompanied with accelerated loss of the pluripotent factors OCT4 and NANOG and decrease in mesoderm marker HAND1 expression. We then identified YAP1 as a direct target of miR-194...
  60. Evans D, Avery C, Nalls M, Li G, Barnard J, Smith E, et al. Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet. 2016;25:4350-4368 pubmed publisher
    ..9 × 10-7), and index SNP associations in or near SCN5A, SCN10A, CDKN1A, NFIA, HAND1, TBX5 and SETBP1 replicated in African Americans...
  61. Xu Y, Qiu X, Li R, Liu H, Qu X, Yang Y. [A novel HAND1 mutation associated with sporadic dilated cardiomyopathy]. Zhonghua Yi Xue Za Zhi. 2017;97:3371-3375 pubmed publisher
    b>Objective: To investigate a novel mutation in the HAND1 gene associated with sporadic dilated cardiomyopathy (DCM)...
  62. Firulli B, Hadzic D, McDaid J, Firulli A. The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem. 2000;275:33567-73 pubmed
    dHAND and eHAND are basic helix-loop-helix (bHLH) transcription factors expressed during embryogenesis and are required for the proper development of cardiac and extraembryonic tissues...
  63. Asuthkar S, Gogineni V, Rao J, Velpula K. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors: the protein uPAR is a cytoplasmic sequestration factor for Hand-1. Mol Cancer Ther. 2014;13:1309-22 pubmed publisher
    ..Finally, uPAR overexpression and its association with Hand-1 after IR treatment indicate that uPAR is capable of regulating Hand-1 and that uPAR has a role in the process of IR-induced tumor angiogenesis. ..
  64. Sheng W, Qian Y, Wang H, Ma X, Zhang P, Diao L, et al. DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot. BMC Med Genomics. 2013;6:46 pubmed publisher
    NKX2-5, GATA4 and HAND1 are essential for heart development, however, little is known regarding their epigenetic regulation in the pathogenesis of tetralogy of fallot (TOF)...
  65. Firulli B, Milliar H, Toolan K, Harkin J, Fuchs R, Robling A, et al. Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis. Development. 2017;144:2480-2489 pubmed publisher
    ..In this study, we examine the consequences of altering Hand1 dimer choice regulation within developing vertebrate limbs...
  66. Martinez Hoyos J, Ferraro A, Sacchetti S, Keller S, De Martino I, Borbone E, et al. HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas. Oncogene. 2009;28:876-85 pubmed publisher
    ..Here, we show that Hand1 gene, which codes for a transcription factor crucial for differentiation of trophoblast giant cells and heart ..
  67. Kim H, Lee H, Park H, Lee D, Boles E, Chung D, et al. Enhanced production of xylitol from xylose by expression of Bacillus subtilis arabinose:H+ symporter and Scheffersomyces stipitis xylose reductase in recombinant Saccharomyces cerevisiae. Enzyme Microb Technol. 2017;107:7-14 pubmed publisher
    ..VW4000, a hxt null mutant. The resulting strain of EXHA exhibited 4...
  68. Russell M, Baker P, Izumo S. Cloning, chromosomal mapping, and expression of the human eHAND gene. Mamm Genome. 1997;8:863-5 pubmed
  69. Barnes R, Firulli B, Vandusen N, Morikawa Y, Conway S, Cserjesi P, et al. Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res. 2011;108:940-9 pubmed publisher
    The basic helix-loop-helix (bHLH) transcription factors Hand1 and Hand2 are essential for embryonic development. Given their requirement for cardiogenesis, it is imperative to determine their impact on cardiovascular function...
  70. Nijland J, Shin H, de Waal P, Klaassen P, Driessen A. Increased xylose affinity of Hxt2 through gene shuffling of hexose transporters in Saccharomyces cerevisiae. J Appl Microbiol. 2017;: pubmed publisher
    ..We have used a gene shuffling approach of hexose (Hxt) transporters in order to increase the affinity for D-xylose.
  71. Srivastava D. HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med. 1999;9:11-8 pubmed
    ..dHAND and eHAND are two related basic helix-loop-helix transcription factors that are expressed in a complementary fashion in the ..
  72. Srivastava D, Gottlieb P, Olson E. Molecular mechanisms of ventricular hypoplasia. Cold Spring Harb Symp Quant Biol. 2002;67:121-5 pubmed
  73. Vincentz J, Vandusen N, Fleming A, Rubart M, Firulli B, Howard M, et al. A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci. 2012;32:2110-20 pubmed publisher
    ..Here, we define a 1007 bp cis-regulatory element 5' of the Hand1 gene sufficient to drive reporter expression within the sympathetic chain of transgenic mice...
  74. Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, et al. Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome. PLoS ONE. 2014;9:e102796 pubmed publisher
    ..cells showed transcriptional repression of NKX2-5, reduced levels of TBX2 and NOTCH/HEY signaling, and inhibited HAND1/2 transcripts compared with control cells...
  75. Nieto G, Martinez L, Castillo J, Ros G. Hydroxytyrosol extracts, olive oil and walnuts as functional components in chicken sausages. J Sci Food Agric. 2017;97:3761-3771 pubmed publisher
    ..Three extracts of hydroxytyrosol obtained using different extraction processes (HXT 1, 2, 3) (50?ppm) were evaluated for use as antioxidants in eight different chicken sausage formulas enriched in ..
  76. Firulli B, Toolan K, Harkin J, Millar H, PINEDA S, Firulli A. The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice. Cardiovasc Res. 2017;: pubmed publisher
    To test if a human Hand1 frame shift mutation identified in human samples is causative of hypoplastic left heart syndrome (HLHS).
  77. Firulli B, Howard M, McDaid J, McIlreavey L, Dionne K, Centonze V, et al. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell. 2003;12:1225-37 pubmed
    The bHLH factors HAND1 and HAND2 are required for heart, vascular, neuronal, limb, and extraembryonic development. Unlike most bHLH proteins, HAND factors exhibit promiscuous dimerization properties...
  78. Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, et al. Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. Gastric Cancer. 2013;16:488-97 pubmed publisher
    ..Examined loci were the promoter CpG islands of six genes (FLNc, HAND1, THBD, p41ARC, HRASLS, and LOX) and the CpG sites of non-coding repetitive elements (Alu and Sat?) that are ..
  79. Adamczyk M, Szatkowska R. Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment. PLoS ONE. 2017;12:e0185516 pubmed publisher
    ..via the major signaling pathways, broadly recognized as on/off switch essential to either positive or negative HXT gene regulation, remain entirely intact...
  80. Weber M, de Clarke V, Harwin R, Shiff C. An extended field trial of pyrimethamine combined with dapsone in the prophylaxis of malaria. Cent Afr J Med. 1975;21:187-92 pubmed
  81. Bounpheng M, Morrish T, Dodds S, Christy B. Negative regulation of selected bHLH proteins by eHAND. Exp Cell Res. 2000;257:320-31 pubmed
    The bHLH protein eHAND plays an important role in the development of extraembryonic, mesodermal, and cardiac cell lineages, presumably through heterodimerization with other HLH proteins and DNA binding...
  82. Hill A, Riley P. Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. Mol Cell Biol. 2004;24:9835-47 pubmed
    The basic helix-loop-helix (bHLH) factor Hand1 plays an essential role in cardiac morphogenesis, and yet its precise function remains unknown...
  83. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
  84. Li L, Wang J, Liu X, Liu H, Shi H, Yang X, et al. HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle. Int J Mol Med. 2017;39:711-718 pubmed publisher
    ..study, the coding exons and flanking introns of the heart and neural crest derivatives expressed transcript 1 (HAND1) gene, which encodes a basic helix?loop?helix transcription factor crucial for cardiovascular development, were ..
  85. Bao S, Tang W, Wu B, Kim S, Li J, Li L, et al. Derivation of hypermethylated pluripotent embryonic stem cells with high potency. Cell Res. 2017;: pubmed publisher
    ..the expression of both naive pluripotency genes, as well as mesodermal somatic genes; Eomes, Eras, Tdgf1, Evx1, hand1, Wnt5a and distinct repetitive elements. Conversion of established ESCs to ASCs is also achievable...
  86. Lu S, Du P, Shan C, Wang Y, Ma C, Dong J. Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. Biochem Biophys Res Commun. 2016;478:1726-31 pubmed publisher
    Previous studies have demonstrated a significantly lower level of Hand1 in ischemic cardiomyopathy than in normal heart tissue. The role of decreased Hand1 in myocardial infarction remains unclear...
  87. Freire M, Cofrades S, Serrano Casas V, Pintado T, Jimenez M, Jimenez Colmenero F. Gelled double emulsions as delivery systems for hydroxytyrosol and n-3 fatty acids in healthy pork patties. J Food Sci Technol. 2017;54:3959-3968 pubmed publisher
    ..the suitability of gelled double emulsions (GDE) for use as a delivery system for n-3 PUFAs and hydroxytyrosol (Hxt) in pork patties...
  88. Zhang T, Galdieri L, Hasek J, Vancura A. Yeast phospholipase C is required for stability of casein kinase I Yck2p and expression of hexose transporters. FEMS Microbiol Lett. 2017;364: pubmed publisher
    ..C (Plc1p) in Saccharomyces cerevisiae is required for normal degradation of repressor Mth1p and expression of the HXT genes encoding cell membrane transporters of glucose...
  89. Knöfler M, Meinhardt G, Vasicek R, Husslein P, Egarter C. Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart. Gene. 1998;224:77-86 pubmed
    The basic helix-loop-helix (bHLH) factor Hand1 plays a role in the developing chicken heart and is required for trophoblast giant cell differentiation and cardiac looping of mouse embryonic development...
  90. Hatemi A, Güleç C, Cine N, Vural B, Hatirnaz O, Sayitoglu M, et al. Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism. Anadolu Kardiyol Derg. 2011;11:319-28 pubmed publisher
    ..The HAND1 is another transcription factor expressed in the heart, and it is characterized by an asymmetrical pattern of ..
  91. Wagh V, Pomorski A, Wilschut K, Piombo S, Bernstein H. MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2014;5:75 pubmed publisher
    ..Further analysis showed that miR-363 overexpression resulted in downregulation of HAND1 mRNA and protein levels...
  92. Wang J, Hu X, Guo Y, Gu J, Xu J, Li Y, et al. HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot. Pediatr Cardiol. 2017;38:547-557 pubmed publisher
    ..venous blood samples of 165 unrelated patients with CHD, and the coding exons and splicing junction sites of the HAND1 gene, which encodes a basic helix-loop-helix transcription factor essential for cardiovascular development, were ..