Gene Symbol: HAGE
Description: DEAD-box helicase 43
Alias: CT13, HAGE, DEAD (Asp-Glu-Ala-Asp) box polypeptide 43, DEAD box protein HAGE, DEAD-box protein 43, cancer/testis antigen 13, helical antigen
Species: human
Products:     HAGE

Top Publications

  1. Mathieu M, Knights A, Pawelec G, Riley C, Wernet D, Lemonnier F, et al. HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides. Cancer Immunol Immunother. 2007;56:1885-95 pubmed
    ..several melanoma tissues and cell lines but not normal tissues were found to overexpress the cancer-testis antigen HAGE at the mRNA and protein level...
  2. Linley A, Mathieu M, Miles A, Rees R, McArdle S, Regad T. The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. J Biol Chem. 2012;287:13633-43 pubmed publisher
    ..Here, we identified a critical role for the DEAD-box helicase antigen (HAGE) in ABCB5+ MMIC-dependent tumorigenesis and show that HAGE-specific inactivation inhibits melanoma tumor growth ..
  3. de Assis A, Rech A, Longoni A, da Silva Morrone M, de Bittencourt Pasquali M, Perry M, et al. Dietary n-3 polyunsaturated fatty acids revert renal responses induced by a combination of 2 protocols that increase the amounts of advanced glycation end product in rats. Nutr Res. 2015;35:512-22 pubmed publisher
    ..Adult Wistar rats were divided into 6 groups that received the following diets for 4 weeks: (1) control group; 2) HAGE: high AGE fat-containing diet group; (3) HAGE + n-3: high AGE fat-containing diet plus n-3 PUFAs group; (4) ..
  4. Lin J, Ma J, Yang J, Yin J, Chen X, Guo H, et al. Arresting of miR-186 and releasing of H19 by DDX43 facilitate tumorigenesis and CML progression. Oncogene. 2018;37:2432-2443 pubmed publisher
  5. Van Tongelen A, Loriot A, De Smet C. Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. Cancer Lett. 2017;396:130-137 pubmed publisher
    ..Importantly, considering their highly restricted pattern of expression, cancer-germline genes may represent valuable targets for the development of anti-cancer therapies with limited side effects. ..
  6. Aljaroudi W, Hage F. Review of Cardiovascular Imaging in the Journal of Nuclear Cardiology in 2016. Part 1 of 2: Positron Emission Tomography, Computed Tomography and Magnetic Resonance. J Nucl Cardiol. 2017;24:649-656 pubmed publisher
    ..It has become a tradition at the beginning of each year to summarize some of these key articles (AlJaroudi and Hage in J Nucl Cardiol 22:507-512, 2015, 23:122-130, 2016; Hage and AlJaroudi in J Nucl Cardiol 22:714-719, 2015; 23:493-..
  7. Roy S, Zhao L, Wang X. Distinct Neural Activities in Premotor Cortex during Natural Vocal Behaviors in a New World Primate, the Common Marmoset (Callithrix jacchus). J Neurosci. 2016;36:12168-12179 pubmed
    ..2011; Hage and Nieder, 2013), which casts doubt on the role of the frontal cortex of the Old World monkeys in vocal ..
  8. Kloudova K, Hromádková H, Partlová S, Brtnický T, Rob L, Bartunkova J, et al. Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines. Oncotarget. 2016;7:46120-46126 pubmed publisher
    ..The combination of OV-90 and OVCAR-3 cell lines showed the highest overlap with patients' samples in the TAA expression profile. ..
  9. Martelange V, de Smet C, De Plaen E, Lurquin C, Boon T. Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer Res. 2000;60:3848-55 pubmed
    ..We obtained two cDNA clones that appeared to be tumor specific. The corresponding genes were named SAGE and HAGE because they have the same pattern of expression as genes of the MAGE family...

More Information


  1. Attai H, Rimbey J, Smith G, Brown P. Expression of a Peptidoglycan Hydrolase from Lytic Bacteriophages Atu_ph02 and Atu_ph03 Triggers Lysis of Agrobacterium tumefaciens. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..silico attempts to find a canonical lysis cassette were unsuccessful; however, we found a putative phage peptidoglycan hydrolase (PPH), which contains a C-terminal transmembrane domain...
  2. Chen Q, Lin J, Qian J, Deng Z, Qian W, Yang J, et al. The methylation status of the DDX43 promoter in Chinese patients with chronic myeloid leukemia. Genet Test Mol Biomarkers. 2013;17:508-11 pubmed publisher
    ..469, p=0.004). Our data suggest that hypomethylation of the DDX43 promoter may be an early and frequent molecular event in the development of CML in Chinese patients. ..
  3. Ambrosini G, Khanin R, Carvajal R, Schwartz G. Overexpression of DDX43 mediates MEK inhibitor resistance through RAS Upregulation in uveal melanoma cells. Mol Cancer Ther. 2014;13:2073-80 pubmed publisher
    ..In conclusion, DDX43 induces RAS protein expression and signaling, mediating a novel mechanism of MEK inhibitor resistance. The detection of DDX43 in patients with uveal melanoma could lead to more targeted therapies for this disease. ..
  4. Abdel Fatah T, McArdle S, Agarwal D, Moseley P, Green A, Ball G, et al. HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis. Clin Cancer Res. 2016;22:905-14 pubmed publisher
    The expression of HAGE as a novel prognostic and predictive tool was assessed in 1,079 triple-negative breast cancers (TNBC)...
  5. Mathieu M, Linley A, Reeder S, Badoual C, Tartour E, Rees R, et al. HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers. Cancer Immun. 2010;10:2 pubmed
    ..The helicase antigen HAGE has been identified as a cancer/testis antigen...
  6. Meyer R, Fish A, Lou Q. Use of the Hage framework for theory construction: Factors affecting glucose control in the college-aged student with type 1 diabetes. Appl Nurs Res. 2017;37:61-66 pubmed publisher
    This article describes the Hage framework for theory construction and its application to the clinical problem of glycemic control in college-aged students with type 1 diabetes...
  7. Ma N, Xu H, Luo Z, Zhou J, Zhou Y, Liu M. Expression and significance of DDX43 in lung adenocarcinoma. Pak J Pharm Sci. 2017;30:1491-1496 pubmed
  8. Chen Q, Lin J, Qian J, Yao D, Qian W, Li Y, et al. Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:1171-5 pubmed
    The aim of this study was to investigate the expression status of the helicase antigen (HAGE) transcript and its clinical significance in patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML)...
  9. Lin J, Chen Q, Yang J, Qian J, Deng Z, Qian W, et al. DDX43 promoter is frequently hypomethylated and may predict a favorable outcome in acute myeloid leukemia. Leuk Res. 2014;38:601-7 pubmed publisher
    ..6-10.4 months) (P=0.014). In summary, the DDX43 gene is activated by promoter hypomethylation and DDX43 hypomethylation may be a favorable prognostic factor in AML. ..
  10. Mathieu M, Miles A, Ahmad M, Buczek M, Pockley A, Rees R, et al. The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. Cell Death Dis. 2014;5:e1061 pubmed publisher
    ..Here, we show the involvement of the helicase HAGE in the transcriptional repression of PML expression in ABCB5+ malignant melanoma-initiating cells (ABCB5+ MMICs), a ..
  11. Chen Q, Lin J, Yao D, Qian J, Qian W, Yang J, et al. Aberrant hypomethylation of DDX43 promoter in myelodysplastic syndrome. Br J Haematol. 2012;158:293-296 pubmed publisher
  12. Nagel H, Laskawi R, Eiffert H, Schlott T. Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 2003;56:226-31 pubmed
    ..of putative tumour suppressor genes, FHIT and WT-1, and tumour rejection genes, BAGE, GAGE-1/2, MAGE-1, MAGE-3, and HAGE (which are reported to be important in human cancers), in salivary gland neoplasms...
  13. Talwar T, Vidhyasagar V, Qing J, Guo M, Kariem A, Lu Y, et al. The DEAD-box protein DDX43 (HAGE) is a dual RNA-DNA helicase and has a K-homology domain required for full nucleic acid unwinding activity. J Biol Chem. 2017;292:10429-10443 pubmed publisher
    ..DDX43, also known as HAGE (helicase antigen gene), is a member of the DEAD-box protein family...