HABP2

Summary

Gene Symbol: HABP2
Description: hyaluronan binding protein 2
Alias: FSAP, HABP, HGFAL, NMTC5, PHBP, hyaluronan-binding protein 2, factor VII activating protein, factor VII-activating protease, factor seven-activating protease, hepatocyte growth factor activator-like protein, hyaluronic acid binding protein 2, plasma hyaluronan binding protein
Species: human

Top Publications

  1. ncbi The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)
    J Roemisch
    Aventis Behring GmbH, Preclinical Research and Development, Marburg, Germany
    Blood Coagul Fibrinolysis 13:433-41. 2002
  2. ncbi Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis
    Johann Willeit
    Department of Neurology, University Clinics, Innsbruck, Austria
    Circulation 107:667-70. 2003
  3. ncbi Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism
    Berthold Hoppe
    Institutee of Transfusion Meidicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Blood 105:1549-51. 2005
  4. ncbi The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
    Helen Ireland
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London WC1E 6JF, UK
    Thromb Haemost 92:986-92. 2004
  5. pmc Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)
    Fumie Nakazawa
    Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem J 385:831-8. 2005
  6. doi Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo
    Shingo Yamamichi
    Department of Applied Biological Science, Tokyo Noko University, 3 5 8 Saiwaicho, Fuchu, Tokyo 183 8509, Japan
    Biochem Biophys Res Commun 409:483-8. 2011
  7. pmc Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease
    F Stephan
    Departments of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 10:1165-71. 2012
  8. ncbi The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration
    M Etscheid
    Department of Hematology Transfusion Medicine, Paul Ehrlich Institute, Federal Agency for Sera and Vaccines, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
    Cell Signal 17:1486-94. 2005
  9. ncbi Suppression of lens stalk cell apoptosis by hyaluronic acid leads to faulty separation of the lens vesicle
    H Ozeki
    Department of Ophthalmology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Exp Eye Res 72:63-70. 2001
  10. ncbi Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors
    C W Bardin
    Population Council, New York, NY 10021
    J Steroid Biochem 30:131-9. 1988

Research Grants

  1. ROLE OF HYALURONAN IN TUMOR CELL LOCOMOTION
    Eva Turley; Fiscal Year: 1993
  2. FLUORESCENT DETECTION OF HYALURONAN AND BINDING PROTEINS
    Jodi Dufner Beattie; Fiscal Year: 2000
  3. EPR STUDIES OF DINUCLEAR METAL CLUSTERS IN PROTEINS
    MICHAEL HENDRICH; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications185 found, 100 shown here

  1. ncbi The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)
    J Roemisch
    Aventis Behring GmbH, Preclinical Research and Development, Marburg, Germany
    Blood Coagul Fibrinolysis 13:433-41. 2002
    The recently reported plasmatic, Factor Seven Activating Protease (FSAP), has also been found to be a potent activator of pro-urokinase [single-chain plasminogen activator, urinary type (scuPA)]...
  2. ncbi Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis
    Johann Willeit
    Department of Neurology, University Clinics, Innsbruck, Austria
    Circulation 107:667-70. 2003
    ..Recently, the plasmatic serine protease "factor seven-activating protease" (FSAP) was recognized as a potent activator of prourokinase in vitro...
  3. ncbi Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism
    Berthold Hoppe
    Institutee of Transfusion Meidicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Blood 105:1549-51. 2005
    The factor VII-activating protease (FSAP) variant Marburg I is known to attenuate the profibrinolytic system in vitro and was recently shown to be a significant predictor for the evolution and progression of carotid stenosis...
  4. ncbi The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
    Helen Ireland
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London WC1E 6JF, UK
    Thromb Haemost 92:986-92. 2004
    A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma...
  5. pmc Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)
    Fumie Nakazawa
    Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem J 385:831-8. 2005
    b>FSAP (Factor VII-activating protease) is a new plasma-derived serine protease with putative dual functions in haemostasis, including activation of coagulation Factor VII and generation of urinary-type plasminogen activator (urokinase)...
  6. doi Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo
    Shingo Yamamichi
    Department of Applied Biological Science, Tokyo Noko University, 3 5 8 Saiwaicho, Fuchu, Tokyo 183 8509, Japan
    Biochem Biophys Res Commun 409:483-8. 2011
    Plasma hyaluronan-binding protein (PHBP), an activator of factor VII and prourokinase, is a serine protease circulating as a single-chain proenzyme (pro-PHBP)...
  7. pmc Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease
    F Stephan
    Departments of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 10:1165-71. 2012
    Factor VII-activating protease (FSAP) is a serine protease that circulates in plasma in its inactive single-chain form and can be activated upon contact with dead cells...
  8. ncbi The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration
    M Etscheid
    Department of Hematology Transfusion Medicine, Paul Ehrlich Institute, Federal Agency for Sera and Vaccines, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
    Cell Signal 17:1486-94. 2005
    The hyaluronan-binding protease (HABP) is a serine protease in human plasma which is structurally related to plasminogen activators, coagulation factor XII and hepathocyte growth factor activator...
  9. ncbi Suppression of lens stalk cell apoptosis by hyaluronic acid leads to faulty separation of the lens vesicle
    H Ozeki
    Department of Ophthalmology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Exp Eye Res 72:63-70. 2001
    ..stained either with TUNEL method for detection of apoptosis or with biotinylated hyaluronic acid binding protein (HABP) for hyaluronic acid...
  10. ncbi Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors
    C W Bardin
    Population Council, New York, NY 10021
    J Steroid Biochem 30:131-9. 1988
    ..Hybridization studies suggest that hTeBG is probably even more closely related, if not identical, to hABP. The carboxy-terminal sequences of hTeBG and rABP are also similar to that of protein S, a vitamin-K-dependent ..
  11. ncbi Identification of two gene loci involved in poly-beta-hydroxybutyrate production in Rhodobacter sphaeroides FJ1
    Mei Kwei Yang
    Department of Life Science, Fu Jen University, Taipei, Taiwan
    J Microbiol Immunol Infect 39:18-27. 2006
    ..We isolated a poly-beta-hydroxybutyrate (PHB)-producing bacterium designated Rhodobacter sphaeroides FJ1. To characterize PHB biosynthesis in this organism, we isolated the genes encoding proteins involved in PHB metabolism...
  12. ncbi Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro
    En Mu
    Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, P R China
    Int J Mol Med 26:549-55. 2010
    ..Factor VII-activating protease (FSAP) is a plasma-derived protease which inhibits the proliferation and migration of hepatic stellate cells and vascular ..
  13. pmc Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia
    Jody A Summers Rada
    Departments of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 51:6172-9. 2010
    ..The molecular events associated with choroidal thickening and the regulation of the choroidal response are largely unknown...
  14. doi Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP
    Sina Stephan
    Dade Behring Marburg GmbH, A Siemens Company, Marburg, Germany
    Clin Chem Lab Med 46:1109-16. 2008
    The single nucleotide Marburg I (MRI) polymorphism of the factor VII-activating protease (FSAP) gene, the prourokinase-activating activity of FSAP, and antigen levels of FSAP in plasma have been associated with incidence and progression ..
  15. ncbi Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
    Hernando Curtidor
    Fundacion Instituto de Inmunologia de Colombia and Universidad Nacional de Colombia, Avda Calle 26 No 50 00, Bogota, Colombia
    Biol Chem 388:25-36. 2007
    ..b>HABP 6505 is neither immunogenic nor protection-inducing; therefore, based on our previous reports, critical amino acids ..
  16. pmc Characterization of Plasmodium falciparum integral membrane protein Pf25-IMP and identification of its red blood cell binding sequences inhibiting merozoite invasion in vitro
    Hernando Curtidor
    Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia
    Protein Sci 17:1494-504. 2008
    ..A common RBC surface receptor of apparently 48 kDa was found for both HABPs, plus an additional 31-kDa receptor for HABP 30577...
  17. doi A Maurer's cleft-associated Plasmodium falciparum membrane-associated histidine-rich protein peptide specifically interacts with the erythrocyte membrane
    Jeison Garcia
    Fundacion Instituto de Inmunologia de Colombia, Carrera 50, No 26 00, Bogota, Colombia
    Biochem Biophys Res Commun 380:122-6. 2009
    ..A high-activity binding peptide (HABP) with saturable binding to a 46-kDa erythrocyte membrane protein was identified and its binding was affected by ..
  18. ncbi Identification of hyaluronic acid-binding proteins and their expressions in porcine cumulus-oocyte complexes during in vitro maturation
    Masaki Yokoo
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biol Reprod 67:1165-71. 2002
    ..Of these, the level of expression of 85-kDa HABP increased with cumulus expansion during IVM and was newly detected after culture...
  19. pmc On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIV[triple bond]N, and related species
    Michael P Hendrich
    Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 103:17107-12. 2006
    The electronic properties of an unusually redox-rich iron system, [PhBP(R)3]Fe-Nx (where [PhBP(R)3] is [PhB(CH2PR2)3]-), are explored by Mössbauer, EPR, magnetization, and density-functional methods to gain a detailed picture regarding ..
  20. doi Characterization of structurally unusual diiron N(x)H(y) complexes
    Caroline T Saouma
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 131:10358-9. 2009
    ..diiron complexes featuring bridging N(x)H(y) ligands stabilized by tris(phosphine)borate ([PhB(CH(2)PR(2))(3)] = [PhBP(R)(3)]) ligands have been characterized...
  21. ncbi The stromal reaction in basal cell carcinomas. A prerequisite for tumour progression and treatment strategy
    U Bertheim
    Department of Surgical and Perioperative Sciences Plastic Surgery, University of Umea, S 90185 Umea, Sweden
    Br J Plast Surg 57:429-39. 2004
    ..specimens were then subjected to histological characterization by means of a biotinylated hyaluronan-binding probe (HABP)...
  22. doi Connective tissue response to fractionated thermo-ablative Erbium: YAG skin laser treatment
    M O Bodendorf
    Department of Dermatology, Medical Faculty, University of Leipzig, Philipp Rosenthalstr 23, 04103 Leipzig, Germany
    Int J Cosmet Sci 32:435-45. 2010
    ..Furthermore, immunohistochemical staining for HA was performed by using the HA binding protein (HAbP) and for Coll-I, Coll-III and MMP-1 by using monoclonal antibodies...
  23. doi Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration
    Matthew B Lanktree
    Department of Medicine, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Blood 116:2160-3. 2010
    ..The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing ..
  24. doi Considerations in undertaking a clinical development program for hospital-acquired bacterial pneumonia and/or ventilator-associated bacterial pneumonia
    George H Talbot
    Talbot Advisors, St Davids, Pennsylvania 19087, USA
    Clin Infect Dis 51:S144-9. 2010
    Achieving marketing authorization for an antimicrobial for the treatment of hospital-acquired bacterial pneumonia (HABP) and/or ventilator-associated bacterial pneumonia (VABP) is challenging because each clinical trial and each clinical ..
  25. doi Peptides derived from Mycobacterium tuberculosis Rv2301 protein are involved in invasion to human epithelial cells and macrophages
    M Ocampo
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Carrera 50 No 26 20, Bogota, Colombia
    Amino Acids 42:2067-77. 2012
    ..On the other hand, HABPs, and especially HABP 36507 located at the N-terminus of the protein, facilitated the internalization of fluorescent latex beads into ..
  26. doi Direct chromogenic substrate immuno-capture activity assay for testing of factor VII-activating protease
    Sina Stephan
    Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany
    Clin Chem Lab Med 49:1199-204. 2011
    The Marburg I (MRI) single nucleotide polymorphism (SNP) of the factor VII-activating protease (FSAP) gene has been associated with thrombophilia and atherosclerotic disease. PCR is used to detect the SNP...
  27. doi Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo
    Johannes J Sidelmann
    Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark, Esbjerg, Denmark
    Thromb Res 128:e67-72. 2011
    ..Factor VII-activating protease (FSAP) has potential effects on hemostasis...
  28. doi High electrophilicity at silicon in η3-silane σ-complexes: Lewis base adducts of a silane ligand, featuring octahedral silicon and three Ru-H-Si interactions
    Mark C Lipke
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 133:16374-7. 2011
    New η(3)-silane σ-complexes [PhBP(Ph)(3)]RuH(η(3)-H(2)SiRR') (RR' = PhMe, Ph(2)) were synthesized. Lewis bases [THF, 4-(dimethylamino)pyridine, and PMe(3)] coordinate to the silicon centers of these complexes to form stable adducts...
  29. pmc The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2)
    Elfie Kathrin Roedel
    Institute for Biochemistry, Justus Liebig University Giessen, 35392 Giessen, Germany
    J Biol Chem 288:7193-203. 2013
    Factor VII-activating protease (FSAP) is a circulating protease involved in the pathogenesis of atherosclerosis, calcification, and fibrotic processes...
  30. pmc The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues
    Marika Bogdani
    Matrix Biology Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA, 98101, USA
    Methods Mol Biol 1229:413-30. 2015
    ..The identification of hyaluronan in tissues is achieved by utilizing a highly specific hyaluronan binding protein (HABP) probe that interacts with hyaluronan in tissue sections...
  31. doi Hydrogel patterning by diffusion through the matrix and subsequent light-triggered chemical immobilization
    Zheyi Yi
    Science for Life Laboratory, Department of Chemistry Ångström Laboratory, Uppsala University, Uppsala, SE 75121 Uppsala, Sweden
    ACS Appl Mater Interfaces 7:1194-206. 2015
    ..Moreover, calcium binding to the gradient HABP hydrogel reflects the pattern of immobilized BP groups eventually leading to the graded biomineralization of the ..
  32. pmc Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    PLoS Negl Trop Dis 9:e0003990. 2015
    ..This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucleosome-releasing factor), and neutrophil activation, as evidenced by neutrophil-elastase (ELA) ..
  33. doi HABP2 Gene Mutations Do Not Cause Familial or Sporadic Non-Medullary Thyroid Cancer in a Highly Inbred Middle Eastern Population
    Ali S Alzahrani
    1 Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Thyroid 26:667-71. 2016
    ..Recently, a c.1601G>A, p.G534E mutation in the HABP2 gene was reported to be the underlying genetic defect in a family with seven members affected by NMTC...
  34. doi Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation
    J M Daniel
    Department of Biochemistry, Justus Liebig Universitat Giessen, Giessen, Germany
    J Thromb Haemost 14:2058-2067. 2016
    Essentials Factor VII-activating protease (FSAP) is a plasma protease involved in vascular processes. Neointima formation was investigated after vascular injury in FSAP-/- mice...
  35. doi Advancing New Antibacterial Drug Development for Treatment of Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia
    Joseph G Toerner
    Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
    Clin Infect Dis 63:S37-8. 2016
    ..new antibacterial drug therapies for treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP)...
  36. pmc Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
    Ganesh Chauhan
    Inserm U1219 Bordeaux Population Health Research Center, 146, rue Leo Saignat, 33000, Bordeaux, France
    Curr Cardiol Rep 18:124. 2016
    ..and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2)...
  37. doi Permanent His Bundle Pacing: The Past, Present and Future
    Parikshit S Sharma
    Division of Cardiology Rush University Medical Center, Chicago, IL
    J Cardiovasc Electrophysiol . 2016
    ..We review the anatomy and physiology of the HB, the available data on permanent HB pacing (PHBP), its current and potential future applications. This article is protected by copyright. All rights reserved.
  38. doi Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls
    Benjamin Kern
    Service de Biochimie Hormonologie Métabolisme Nutrition and Oncologie, Centre de Biologie Pathologie, Centre Hospitalier Regional and Universitaire, F 59037 Lille Cedex, France
    Eur J Med Genet . 2017
    A heterozygous germline variant in the HABP2 gene c.1601G > A (p...
  39. ncbi Identification and polymorphism of Plasmodium vivax RBP-1 peptides which bind specifically to reticulocytes
    Mauricio Urquiza
    Fundacion Instituto de Inmunologia de Colombia and Universidad Nacional de Colombia, Cra 50 No 26 00, Bogota, Colombia SA
    Peptides 23:2265-77. 2002
    ..It has been reported that a highly conserved Region-I recombinant fragment binds specifically to reticulocytes. HABP-critical residues for reticulocyte-binding were highly conserved in 20 Colombian P...
  40. ncbi Analysis of a Plasmodium falciparum EBA-175 peptide with high binding capacity to erythrocytes and their analogues using 1H NMR
    Gladys Cifuentes
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Universidad Nacional de Colombia, Carrera 50 No 26 00, Santa Fe de Bogota, Colombia
    J Struct Biol 141:115-21. 2003
    A 175-erythrocyte-binding protein (EBA-175) conserved high-activity binding peptide (HABP), called 1783 (nonimmunogenic, nonprotective against Plasmodium falciparum malaria), was analyzed for antigenic and protective activity in Aotus ..
  41. ncbi Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients
    João R M Martins
    Division of Molecular Biology, Department of Biochemistry, Universidade Federal de Sao Paulo, 04044 São Paulo, SP, Brazil
    Anal Biochem 319:65-72. 2003
    ..Plates were coated with hyaluronan-binding proteins (HABP) obtained from bovine cartilage and successively incubated with samples containing standard solutions of hyaluronan ..
  42. ncbi Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells
    Christian Kannemeier
    Institute for Biochemistry, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 18:728-30. 2004
    The factor VII activating protease (FSAP) is a serine-protease present in human plasma that serves to activate single-chain plasminogen activators, as well as coagulation factor VII...
  43. pmc Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
    Aya Shibamiya
    Institute for Biochemistry, Medical Faculty, Justus Liebig University, 35392 Giessen, Germany
    Biochem J 404:45-50. 2007
    b>FSAP (Factor VII-activating protease) can cleave and inactivate PDGF-BB (platelet-derived growth factor-BB) and thereby inhibits VSMC (vascular smooth-muscle cell) proliferation...
  44. ncbi Identifying merozoite surface protein 4 and merozoite surface protein 7 Plasmodium falciparum protein family members specifically binding to human erythrocytes suggests a new malarial parasite-redundant survival mechanism
    Yesid Garcia
    Fundacion Instituto de Inmunologia de Colombia, Carrera 50 No 26 00, CP 020304, Bogota D C, Colombia, South America
    J Med Chem 50:5665-75. 2007
    ..One MSP-4 high activity binding peptide (HABP) and five MSP-7 HABPs were found having specific binding to RBC surface...
  45. ncbi Effect of hypercortisolism control on high blood pressure in Cushing's syndrome
    Reynaldo M Gomez
    Division Endocrinologia, Hospital de Clinicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 67:439-44. 2007
    ..After treatment, patients were divided into those with persistent high blood pressure (PHBP) and those with normal blood pressure (NBP)...
  46. doi Synthesis and characterization of tyramine-based hyaluronan hydrogels
    Aniq Darr
    Department of Biomedical Engineering, Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mater Sci Mater Med 20:33-44. 2009
    ..Sufficient native HA structure is maintained to allow recognition and binding by b-HABP, a HA binding complex typically found in normal cartilage biology...
  47. doi Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions
    Lars Muhl
    Institute for Biochemistry, Medical School, Justus Liebig University Giessen, Giessen, Germany
    FEBS Lett 583:1994-8. 2009
    b>Factor VII activating protease (FSAP) is associated with cardiovascular diseases and liver fibrosis. To understand the regulation of its proteolytic activity we have characterized recombinant FSAP-mutants over-expressed in HEK-293 cells...
  48. ncbi Acute stress augments innate immunity in the liver and increases hyaluronan levels in the tissues and blood of mice
    Masashi Inoue
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Biomed Res 30:157-63. 2009
    ..The expression of hyaluronan binding protein (HABP) was found to increase in the skin, liver and kidney as shown by immunohistochemical staining...
  49. pmc Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity
    Nurbek Mambetsariev
    Department of Medicine, University of Chicago, CIS Bldg W403E, Chicago, IL 60637, USA
    Arterioscler Thromb Vasc Biol 30:483-90. 2010
    ..We evaluated the role of the extracellular serine protease, hyaluronic acid binding protein 2 (HABP2), in vascular barrier regulation.
  50. pmc Activation of factor VII-activating protease in human inflammation: a sensor for cell death
    Femke Stephan
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory of AMC, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Crit Care 15:R110. 2011
    ..We recently showed that plasma can release nucleosomes from late apoptotic cells. Factor VII-activating protease (FSAP) was identified to be the plasma serine protease responsible for nucleosome release...
  51. doi Factor VII activating protease. Single nucleotide polymorphisms light the way
    S M Kanse
    Department of Medicine, Justus Liebig University, Friedrichstraße 24, 35392 Giessen, Germany
    Hamostaseologie 31:174-6, 177-8. 2011
    b>Factor VII activating protease (FSAP) is a circulating serine protease with high homology to fibrinolytic enzymes...
  52. doi Binding activity, structure, and immunogenicity of synthetic peptides derived from Plasmodium falciparum CelTOS and TRSP proteins
    Hernando Curtidor
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Carrera 50 No 26 20, Bogota, Colombia
    Amino Acids 43:365-78. 2012
    ..Three high-activity binding peptides (HABPs) were found in CelTOS and one HABP was found in TRSP, all of them having high α-helical structure content...
  53. ncbi Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation
    Eisaku Yamamoto
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Biosci Biotechnol Biochem 75:2070-2. 2011
    Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP...
  54. doi FSAP, a new player in inflammation?
    F Stephan
    Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands
    Hamostaseologie 32:51-5. 2012
    Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis...
  55. ncbi Nicotine modulation of factor VII activating protease (FSAP) expression in human monocytes
    Mariana S Parahuleva
    Internal Medicine I Cardiology and Angiology, Giessen, Germany
    J Atheroscler Thromb 19:962-9. 2012
    b>Factor VII activating protease (FSAP) is a plasma serine protease involved in hemostasis and remodeling processes...
  56. pmc Mononuclear five- and six-coordinate iron hydrazido and hydrazine species
    Caroline T Saouma
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Inorg Chem 51:10043-54. 2012
    ..The sterically encumbered tris(di-meta-terphenylphosphino)borate ligand, [PhBP(mter)(3)](-), is introduced to provide access to species that cannot be stabilized with the [PhBP(Ph)(3)](-) ligand ..
  57. pmc Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility
    LEON GARLAND COLEMAN
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599 7178, United States Electronic address
    Pharmacol Biochem Behav 116:142-51. 2014
    ..matrix (ECM) proteins in the adult OFC including WFA (55%), Brevican (32%), Neurocan (105%), Tenacin-C (25%), and HABP (5%)...
  58. pmc Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples
    Elodie Caboux
    Laboratory Services and Biobank, International Agency for Research on Cancer, Lyon, France
    PLoS ONE 8:e79826. 2013
    ..genes (CYP2E1, IGLL1, CABYR, CLDN2, NQO1, SCL13A5) and 6 down-regulated genes (MT1G, MT1H, MT1E, MT1F, HABP2, SPINK1) was identified (FDR <0.05)...
  59. doi Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS
    Dan Dan Xu
    Institute of Cell Biology, Zhejiang University, Hangzhou, P R China
    Proteomics 14:322-31. 2014
    ..differential expression of apolipoprotein CII (APOCII), CD5 antigen-like (CD5L), hyaluronan-binding protein 2 (HABP2), and retinol-binding protein 4 (RBP4) was further confirmed using immunoblotting and ELISA analysis...
  60. doi Factor VII activating protease (FSAP): a novel protective factor in liver fibrosis
    Adoración Martínez-Palacián
    Department of Biochemistry, University of Oslo, Oslo, Norway
    Proteomics Clin Appl 8:438-46. 2014
    b>Factor VII activating protease (FSAP) is a multifunctional serine protease that is mainly synthesized and secreted by hepatocytes...
  61. doi Cooperation of factor VII-activating protease and serum DNase I in the release of nucleosomes from necrotic cells
    Femke Stephan
    Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
    Arthritis Rheumatol 66:686-93. 2014
    ..The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from late apoptotic cells...
  62. pmc High polyhydroxybutyrate production in Pseudomonas extremaustralis is associated with differential expression of horizontally acquired and core genome polyhydroxyalkanoate synthase genes
    Mariela V Catone
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 9:e98873. 2014
    ..In addition, two phasin like proteins (PhbP and PhaI) associated with the production of scl and mcl PHAs, respectively, were detected...
  63. doi Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP)
    Saravanan Subramaniam
    Dr Sandip M Kanse, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway, Tel 47 228 51464, E mail
    Thromb Haemost 113:870-80. 2015
    Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis...
  64. doi Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice
    A U Joshi
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany Chemical and Systems Biology, School of Medicine, Stanford University, Stanford, CA, USA
    Eur J Neurosci 41:965-75. 2015
    b>Factor VII activating protease (FSAP) is a circulating protease with a putative role in hemostasis, remodeling and inflammation...
  65. doi Is it possible to predict the need of inguinal lymphadenectomy in patients with squamous cell carcinoma of the penis? A clinical and a pathological study
    Daniele Minardi
    Institute of Maternal and Children s Sciences Urology, Polytechnic University of the Marche Region, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona
    Arch Ital Urol Androl 87:33-7. 2015
    ....
  66. pmc Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer
    Sudheer Kumar Gara
    From the Endocrine Oncology Branch S K G, L Z, D P, E K, Bioinformatics Core L J and Laboratory of Pathology M J M, Center for Cancer Research, and the Office of Science and Technology Resources M C, National Cancer Institute, and the Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases S K A both in Bethesda, MD
    N Engl J Med 373:448-55. 2015
    ..Here, we report a germline variant of HABP2 in seven affected members of a kindred with familial nonmedullary thyroid cancer and in 4...
  67. pmc HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression
    Tamara Mirzapoiazova
    Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    Front Oncol 5:164. 2015
    ..HA), which we have previously demonstrated can regulate the activity of the extracellular serine protease, hyaluronan binding protein 2 (HABP2). This study examined the functional role of HABP2 on HA-mediated human lung cancer dynamics.
  68. doi Mycobacterium tuberculosis PE9 protein has high activity binding peptides which inhibit target cell invasion
    Diana P Díaz
    Fundacion Instituto de Inmunologia de Colombia FIDIC, 111321 Bogotá, Colombia Universidad del Rosario, 111321 Bogotá, Colombia
    Int J Biol Macromol 86:646-55. 2016
    ..b>HABP 39232 inhibited mycobacterial entry to A549 cells (∼70%) and U937 cells (∼50%), peptides 39226 and 39231 ..
  69. ncbi Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages
    M S Parahuleva
    Internal Medicine Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany
    Eur Rev Med Pharmacol Sci 20:2174-82. 2016
    ..vitamin C in vascular pathophysiology, we have investigated the effect of vitamin C on the tissue factor (TF) and Factor VII Activating Protease (FSAP) expression induced by lipopolysaccharide (LPS) in human monocyte-derived macrophages.
  70. pmc Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes
    Silke Leiting
    From the Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
    J Biol Chem 291:21020-21028. 2016
    Deletion of the Habp2 gene encoding Factor VII-activating protease (FSAP) increases liver fibrosis in mice...
  71. doi Hyaluronan metabolism in overloaded temporomandibular joint
    T Shinohara
    Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
    J Oral Rehabil 43:921-928. 2016
    ..The number of HABP-positive cells was decreased by mechanical overloading and with age...
  72. doi Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor
    Kunihiro Ikuta
    Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine 65, Nagoya, 466 8550, Japan
    Int J Cancer 140:469-479. 2017
    ..HA binding protein (HABP) staining, particle exclusion assay and quantification of HA revealed that MU significantly decreased HA ..
  73. ncbi Alpha helix shortening in 1522 MSP-1 conserved peptide analogs is associated with immunogenicity and protection against P. falciparum malaria
    Marcia Cubillos
    Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia
    Proteins 50:400-9. 2003
    1522 is a nonimmunogenic conserved high-activity binding peptide (HABP) belonging to Plasmodium falciparum MSP-1 protein N-terminal fragment...
  74. ncbi Covalently coupling the antibody on an amine-self-assembled gold surface to probe hyaluronan-binding protein with capacitance measurement
    Dechen Jiang
    Department of Chemistry, Fudan University, 200433, Shanghai, People s Republic of China
    Biosens Bioelectron 18:1183-91. 2003
    ..The novel immunosensor supplied a label-free detection method for HABP, which was based on measuring the capacitance change in-between the unlabeled HABP (antigen) and rabbit-anti-HABP (..
  75. ncbi Shortening and modifying the 1513 MSP-1 peptide's alpha-helical region induces protection against malaria
    Fabiola Espejo
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Universidad Nacional de Colombia Bogota, Cra 50 No 26 00, Bogota, Colombia
    Biochem Biophys Res Commun 315:418-27. 2004
    ..semi-conserved sequences have been shown to contain red blood cell (RBC) membrane high affinity binding peptides (HABP)...
  76. ncbi Correlation between solid-state structures and enzymatic degradability of cocrystallized blends
    Yuuki Hirota
    Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 B 55 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Macromol Biosci 5:1094-100. 2005
    ..between poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [PHBV] and poly(3-hydroxybutyrate-co-3-hydroxypropionate) [PHBP]...
  77. ncbi Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Biol Chem 282:21671-82. 2007
    Factor VII-activating protease (FSAP) is a novel plasma-derived serine protease structurally homologous to tissue-type and urokinase-type plasminogen activators...
  78. doi Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunity
    Manuel E Patarroyo
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Bogota, Colombia
    Biochem Biophys Res Commun 429:75-80. 2012
    Modified HABP (mHABP) regions interacting with HLA-DRβ1(∗) molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an ..
  79. doi Factor seven activating protease (FSAP) expression in human placenta and its role in trophoblast migration
    Mariana S Parahuleva
    Internal Medicine I Cardiology and Angiology, Justus Liebig University, Klinikstrasse 36, Giessen, Germany
    Eur J Obstet Gynecol Reprod Biol 167:34-40. 2013
    b>Factor seven activating protease (FSAP) is a plasma serine protease known to play a critical role in hemostasis and remodeling processes: FSAP levels increase markedly during normal pregnancy...
  80. pmc Serum Proteome Changes in Healthy Subjects with Different Genotypes of NOS1AP in the Chinese Population
    Feng Jiang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, China
    J Diabetes Res 2013:357630. 2013
    ..Four proteins were identified, including apoA4, alpha1-ACT, HABP2, and keratin 10, with blood levels changed significantly between CC and AA homozygotes of rs12742393...
  81. doi Molecular cloning and tissue distribution of hyaluronan binding protein 2 (HABP2) in red sea bream Pagrus major
    Asami Yoshida
    Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, 1 14 Bunkyo, Nagasaki 852 8521, Japan
    Comp Biochem Physiol B Biochem Mol Biol 165:271-6. 2013
    ..The enzyme has a similar domain structure and tissue distribution to those of human hyaluronan binding protein 2 (HABP2) engaged in the extracellular matrix (ECM) turnover...
  82. pmc Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein
    Han Yuan
    Department of Chemical and Biomolecular Engineering, Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY 11201, USA
    Glycobiology 23:1270-80. 2013
    ..concentration is most commonly determined by the use of a labeled specific HA binding protein (aggrecan G1-IGD-G2, HABP), employing membrane blotting and sandwich enzyme-linked immunosorbent assay (ELISA)-like methods...
  83. doi Regulation of monocyte/macrophage function by factor VII activating protease (FSAP)
    Mariana S Parahuleva
    Internal Medicine I Cardiology and Angiology, Innere Medizin I Kardiologie, Bad Homburg, Germany Electronic address
    Atherosclerosis 230:365-72. 2013
    b>Factor VII activating protease (FSAP) is a novel regulator of vascular inflammation and hemostasis...
  84. pmc Identification and characterization of three cDNAs that encode putative novel hyaluronan-binding proteins, including an endothelial cell-specific hyaluronan receptor
    E Tsifrina
    Department of Vascular Biology, Jerome H Holland Laboratory, American Red Cross, Rockville, Maryland, USA
    Am J Pathol 155:1625-33. 1999
    ..DNA sequence analysis revealed that two of the novel HABPs, WF-HABP and BM-HABP, form a unique HA-binding subfamily, whereas the third protein, OE-HABP, is more closely related to the ..
  85. ncbi Identification of specific Hep G2 cell binding regions in Plasmodium falciparum sporozoite-threonine-asparagine-rich protein (STARP)
    Ramses Lopez
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Universidad Nacional de Colombia, Carrera 50 No 26 00, Bogota, Colombia
    Vaccine 21:2404-11. 2003
    ..SDS-PAGE results showed that both peptides 20570 and 20547 had at least two different sets of 44 and 38 kDa HABP receptors on Hep G2 cells...
  86. ncbi Plasmodium falciparum: red blood cell binding studies using peptides derived from rhoptry-associated protein 2 (RAP2)
    Ramses Lopez
    Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia
    Biochimie 86:1-6. 2004
    ..and 26229 ((241)RSVNNVISKNKTLGLRKRSS(260)) were located in the amino terminal and central part of the protein and HABP 26235 ((361)FLAEDFVELFDVTMDCYSRQ(380)) was located at the carboxy terminal...
  87. pmc Detection of hydroxyapatite in calcified cardiovascular tissues
    Jae Sam Lee
    Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College of Cornell University, 6565 Fannin Street, B5 009, Houston, TX 77030, USA
    Atherosclerosis 224:340-7. 2012
    ..This method uses a novel optical molecular imaging contrast dye, Cy-HABP-19, to target calcified cells and tissues.
  88. doi The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity
    M Etscheid
    Department of Hematology Transfusion Medicine, Paul Ehrlich Institute, Langen, Germany
    Thromb Res 130:935-41. 2012
    b>Factor VII activating protease (FSAP) is a plasma protease with FVII and pro-urokinase (pro-uPA) activating properties...
  89. doi Stabilization of ArSiH4(-) and SiH6(2-) anions in diruthenium Si-H σ-complexes
    Mark C Lipke
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 1460, USA
    Angew Chem Int Ed Engl 51:11115-21. 2012
    ..anions ([ArSiH(4)](-) and [SiH(6)](2-)) were stabilized as ligands in diruthenium Si-H σ-complexes [{(PhBP(Ph(3))Ru}(2)(μ-Cl)(μ-η(3),η(3)-H(4)SiAr)] (Ar = 2-MeOC(6)H(4), Mes, Ph) and [{(PhBP(Ph)(3))Ru}(2)(μ-η(4),η(4)..
  90. doi Protective immunity provided by a new modified SERA protein peptide: its immunogenetic characteristics and correlation with 3D structure
    Adriana Bermudez
    Fundacion Instituto de Inmunologia de Colombia FIDIC, Carrera 50 No 26 00, Bogota, Colombia
    Amino Acids 43:183-94. 2012
    ..The 6733 HABP was located in the C-terminal portion of the 47-kDa fragment while HABP 6754 was located in the C-terminal region ..
  91. doi Hyaluronan in part mediates IL-1beta-induced inflammation in mouse chondrocytes by up-regulating CD44 receptors
    Giuseppe M Campo
    Department of Biochemical, Physiological and Nutritional Sciences, section of Medical Chemistry, School of Medicine, University of Messina, Policlinico Universitario, Messina, Italy
    Gene 494:24-35. 2012
    ..Specific CD44 blocking antibody and hyaluronan binding protein (HABP), which inhibit HA activity, were used to confirm CD44 to be the target of IL-1beta action through HA mediation...
  92. doi Factor seven activating protease (FSAP): does it activate factor VII?
    F Stavenuiter
    Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
    J Thromb Haemost 10:859-66. 2012
    b>Factor seven activating protease (FSAP) was initially reported as an activator of single-chain urokinase-type plasminogen activator (scuPA) and factor VII (FVII)...
  93. doi Factor seven activating protease activity levels in women with recurrent pregnancy loss
    Silvia Riondino
    Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    Reprod Sci 19:317-21. 2012
    This study was designed to analyze the changes in circulating factor seven activating protease (FSAP) levels in association with the thrombophilic state of 40 women with recurrent pregnancy loss (RPL)...
  94. doi The G534E-polymorphism of the gene encoding the factor VII-activating protease is a risk factor for venous thrombosis and recurrent events
    Parviz Ahmad-Nejad
    Institute for Clinical Chemistry, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany
    Thromb Res 130:441-4. 2012
    A single nucleotide polymorphism of the factor VII activating protease (FSAP), FSAP Marburg I (rs7080536) has been identified as a risk factor for venous thrombosis, but its clinical role has so far been controversial in part due to small ..
  95. doi Lac color inhibits development of rat thyroid carcinomas through targeting activation of plasma hyaluronan-binding protein
    Sayaka Kemmochi
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo 183 8509, Japan
    Exp Biol Med (Maywood) 237:728-38. 2012
    ..that potentiate inhibition of tissue proteolysis mediated by activation of plasma hyaluronan-binding protein (PHBP)...
  96. doi Risk assessment and risk management at the Canadian Food Inspection Agency (CFIA): a perspective on the monitoring of foods for chemical residues
    Henri P Bietlot
    Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON, Canada
    Drug Test Anal 4:50-8. 2012
    ..testing programmes are the National Chemical Residue Monitoring Program (NCRMP) and the Food Safety Action Plan (FSAP)...
  97. ncbi A hyaluronate binding protein transiently codistributes with p21k-ras in cultured cell lines
    E Turley
    Department of Pharmacology, School of Medicine, University of Calgary, Alberta, Canada
    Exp Cell Res 182:340-8. 1989
    Hyaluronate (HA) affects the migratory and adhesive properties of cells. HABP, one of the sites which bind HA, localizes in the ruffling lamellae of normal migrating fibroblasts...
  98. ncbi Traumatic rotatory displacement of the lower cervical spine
    C Argenson
    , , Nice, France
    Spine (Phila Pa 1976) 13:767-73. 1988
    ..bony lesions, which can set free the articular facets, are called fracture separation of the articular pillar (FSAP): nine cases...
  99. ncbi Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator
    N H Choi-Miura
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo
    J Biochem 119:1157-65. 1996
    A novel hyaluronan-binding protein (PHBP) was purified from human plasma by affinity chromatography on hyaluronan-conjugated Sepharose...
  100. ncbi Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein
    K Hashimoto
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Biol Pharm Bull 20:1127-30. 1997
    The cDNA which encodes the mouse counterpart of human plasma hyaluronan-binding protein (PHBP) was isolated and characterized...

Research Grants3

  1. ROLE OF HYALURONAN IN TUMOR CELL LOCOMOTION
    Eva Turley; Fiscal Year: 1993
    ..tyrosine phosphorylation and that this effect is mediated by HARC which contains a hyaluronan binding protein (HABP) and a protein tyrosine kinase that is related to pp60c-src...
  2. FLUORESCENT DETECTION OF HYALURONAN AND BINDING PROTEINS
    Jodi Dufner Beattie; Fiscal Year: 2000
    ..and purify fluorescent HAs with three nonoverlapping fluorophores, (iii) develop fluorescence-based assays for HA-HABP interactions and hyaluronidase (HAse) activity, and (iv) develop a fluorescently-labeled recombinant HABP for HA ..
  3. EPR STUDIES OF DINUCLEAR METAL CLUSTERS IN PROTEINS
    MICHAEL HENDRICH; Fiscal Year: 2002
    ..In particular, the oxidation states of dinuclear metal clusters that are of main biological importance, are states that predominantly have an even number of electrons. ..