HABP2

Summary

Gene Symbol: HABP2
Description: hyaluronan binding protein 2
Alias: FSAP, HABP, HGFAL, NMTC5, PHBP, hyaluronan-binding protein 2, factor VII activating protein, factor VII-activating protease, factor seven-activating protease, hepatocyte growth factor activator-like protein, hyaluronic acid binding protein 2, plasma hyaluronan binding protein
Species: human
Products:     HABP2

Top Publications

  1. Roemisch J, Feussner A, Nerlich C, Stoehr H, Weimer T. The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP). Blood Coagul Fibrinolysis. 2002;13:433-41 pubmed
    The recently reported plasmatic, Factor Seven Activating Protease (FSAP), has also been found to be a potent activator of pro-urokinase [single-chain plasminogen activator, urinary type (scuPA)]...
  2. Etscheid M, Beer N, Dodt J. The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration. Cell Signal. 2005;17:1486-94 pubmed
    The hyaluronan-binding protease (HABP) is a serine protease in human plasma which is structurally related to plasminogen activators, coagulation factor XII and hepathocyte growth factor activator...
  3. Ahmad Nejad P, Dempfle C, Weiss C, Bugert P, Borggrefe M, Neumaier M. The G534E-polymorphism of the gene encoding the factor VII-activating protease is a risk factor for venous thrombosis and recurrent events. Thromb Res. 2012;130:441-4 pubmed publisher
    A single nucleotide polymorphism of the factor VII activating protease (FSAP), FSAP Marburg I (rs7080536) has been identified as a risk factor for venous thrombosis, but its clinical role has so far been controversial in part due to small ..
  4. Stephan F, Dienava Verdoold I, Bulder I, Wouters D, Mast A, te Velthuis H, et al. Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease. J Thromb Haemost. 2012;10:1165-71 pubmed publisher
    Factor VII-activating protease (FSAP) is a serine protease that circulates in plasma in its inactive single-chain form and can be activated upon contact with dead cells...
  5. Willeit J, Kiechl S, Weimer T, Mair A, Santer P, Wiedermann C, et al. Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. Circulation. 2003;107:667-70 pubmed
    ..Recently, the plasmatic serine protease "factor seven-activating protease" (FSAP) was recognized as a potent activator of prourokinase in vitro...
  6. Hoppe B, Tolou F, Radtke H, Kiesewetter H, Dorner T, Salama A. Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. Blood. 2005;105:1549-51 pubmed
    The factor VII-activating protease (FSAP) variant Marburg I is known to attenuate the profibrinolytic system in vitro and was recently shown to be a significant predictor for the evolution and progression of carotid stenosis...
  7. Nakazawa F, Kannemeier C, Shibamiya A, Song Y, Tzima E, Schubert U, et al. Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP). Biochem J. 2005;385:831-8 pubmed
    b>FSAP (Factor VII-activating protease) is a new plasma-derived serine protease with putative dual functions in haemostasis, including activation of coagulation Factor VII and generation of urinary-type plasminogen activator (urokinase)...
  8. Yamamichi S, Fujiwara Y, Kikuchi T, Nishitani M, Matsushita Y, Hasumi K. Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo. Biochem Biophys Res Commun. 2011;409:483-8 pubmed publisher
    Plasma hyaluronan-binding protein (PHBP), an activator of factor VII and prourokinase, is a serine protease circulating as a single-chain proenzyme (pro-PHBP)...
  9. Ireland H, Miller G, Webb K, Cooper J, Humphries S. The factor VII activating protease G511E (Marburg) variant and cardiovascular risk. Thromb Haemost. 2004;92:986-92 pubmed
    A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma...

More Information

Publications118 found, 100 shown here

  1. Choi Miura N, Takahashi K, Yoda M, Saito K, Mazda T, Tomita M. Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein. Biol Pharm Bull. 2001;24:448-52 pubmed
    We prepared anti-plasma hyaluronan binding protein (PHBP) mouse monoclonal antibodies and studied the fragmentation profile of PHBP with them. PHBP is present in human plasma as a single polypeptide chain (70 kDa)...
  2. Bjork A, Sosin D. Characterization of Departures from Regulatory Requirements Identified During Inspections Conducted by the US Federal Select Agent Program, 2014-15. Health Secur. 2017;15:587-598 pubmed publisher
    We studied departures from regulatory requirements identified on US Federal Select Agent Program (FSAP) inspections to increase transparency regarding biosafety and security risk at FSAP-regulated entities and identify areas for ..
  3. Brand J, Humphreys K, Li J, Karlsson R, Hall P, Czene K. Common genetic variation and novel loci associated with volumetric mammographic density. Breast Cancer Res. 2018;20:30 pubmed publisher
    ..three novel MD loci were identified (at P < 5 × 10- 8): one for percent dense volume (HABP2) and two for the absolute dense volume (INHBB, LINC01483)...
  4. Hu M, Li H, Bogoyevitch M, Jans D. Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production. Biochem Biophys Res Commun. 2017;489:460-465 pubmed publisher
    ..Here we examine the role in infection of the host mitochondrial protein p32 (HABP/gC1qR/C1qbp) for the first time...
  5. Pang F, Jia X, Zhao Q, Zhang Y. Factors associated to prevalence and treatment of carbapenem-resistant Enterobacteriaceae infections: a seven years retrospective study in three tertiary care hospitals. Ann Clin Microbiol Antimicrob. 2018;17:13 pubmed publisher
    ..complicated urinary tract infection (cUTI)/acute pyelonephritis (AP), hospital-acquired bacterial pneumonia (HABP), superficial wound infection (SWI), biliary tract infection (BTI), deep wound infection (DWI) and sterile body ..
  6. Husseini Akram F, Haroun S, Altmäe S, Skjöldebrand Sparre L, Akerud H, Poromaa I, et al. Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage. BMC Womens Health. 2018;18:143 pubmed publisher
    ..is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested...
  7. Franchi F, Martinelli I, Biguzzi E, Bucciarelli P, Mannucci P. Marburg I polymorphism of factor VII-activating protease and risk of venous thromboembolism. Blood. 2006;107:1731 pubmed
  8. Hu Y, Ma Y, Sun R, Yu X, Xie H, Wang W. Amine-Catalyzed Highly Regioselective and Stereoselective C(sp(2) )-C(sp(2) ) Cross-Coupling of Naphthols with trans-α,β-Unsaturated Aldehydes. Chem Asian J. 2015;10:1859-63 pubmed publisher
    ..The mild reaction conditions with pyridine hydrobromideperbromide (PHBP) as the bromination reagent in the presence of piperidine or diphenylprolinol trimethylsilyl (TMS) ether as ..
  9. Smith I, Crombie N, Bishop J, McLaughlin A, Naumann D, Herbert M, et al. RePHILL: protocol for a randomised controlled trial of pre-hospital blood product resuscitation for trauma. Transfus Med. 2017;: pubmed publisher
    To describe the 'Resuscitation with Pre-HospItaL bLood products' trial (RePHILL) - a multi-centre randomised controlled trial of pre-hospital blood product (PHBP) administration vs standard care for traumatic haemorrhage.
  10. Trbakovic A, Hedenqvist P, Mellgren T, Ley C, Hilborn J, Ossipov D, et al. A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model. J Dent. 2018;70:31-39 pubmed publisher
    ..calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid-calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model...
  11. Etscheid M, Beer N, Fink E, Seitz R, Johannes D. The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin. Biol Chem. 2002;383:1633-43 pubmed
    ..Since they are structurally unrelated in their heavy chains (propeptide), their similar in vivo catalytic activities might be directed at distinct sites where PHBSP could induce processes that are related to the kallikrein/kinin system. ..
  12. Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, et al. Hyaluronic acid is present on specific perineuronal nets in the mouse cerebral cortex. Brain Res. 2018;1698:139-150 pubmed publisher
    ..To elucidate the cortical region-specific distribution of HA, we quantitatively analyzed HA binding protein (HABP)-positive PNNs in the mature mouse cerebral cortex...
  13. Sharma P, Trohman R. An Electro-Anatomic Atlas of His Bundle Pacing: Combining Fluoroscopic Imaging and Recorded Electrograms. Card Electrophysiol Clin. 2018;10:483-490 pubmed publisher
    Permanent His bundle pacing (PHBP) has gained significant popularity given improved implant success rates given better tools and increasing data on the clinical benefits of PHBP...
  14. Gupta S, Batchu R, Datta K. Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. Eur J Cell Biol. 1991;56:58-67 pubmed
    Hyaluronic acid binding protein (HABP) has been purified to homogeneity from normal adult rat kidney by hyaluronate Sepharose affinity chromatography, and its apparent molecular mass was found to be 68 kDa...
  15. Altmäe S, Kallak T, Fridén B, Stavreus Evers A. Variation in hyaluronan-binding protein 2 (HABP2) promoter region is associated with unexplained female infertility. Reprod Sci. 2011;18:485-92 pubmed publisher
    We set up to analyze polymorphisms in hyaluronan-binding protein 2 (HABP2) gene in healthy fertile women (n = 158) and in women with unexplained infertility (n = 116) and to investigate the potential role of HABP2 in receptive ..
  16. Riondino S, Ferroni P, La Farina F, Martini F, Palmirotta R, Guadagni F, et al. Factor seven activating protease activity levels in women with recurrent pregnancy loss. Reprod Sci. 2012;19:317-21 pubmed publisher
    This study was designed to analyze the changes in circulating factor seven activating protease (FSAP) levels in association with the thrombophilic state of 40 women with recurrent pregnancy loss (RPL)...
  17. Joshi A, Orset C, Engelhardt B, Baumgart Vogt E, Gerriets T, Vivien D, et al. Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice. Eur J Neurosci. 2015;41:965-75 pubmed publisher
    b>Factor VII activating protease (FSAP) is a circulating protease with a putative role in hemostasis, remodeling and inflammation...
  18. Castro Chavez F, Vickers K, Lee J, Tung C, Morrisett J. Effect of lyso-phosphatidylcholine and Schnurri-3 on osteogenic transdifferentiation of vascular smooth muscle cells to calcifying vascular cells in 3D culture. Biochim Biophys Acta. 2013;1830:3828-34 pubmed publisher
    ..When the 3D cultures were treated with a fluorescent probe specific for calcium hydroxyapatite (FITC-HABP-19), the cell extensions/rods emitted intensely at 518nm, the λmax for FITC emission...
  19. Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset P, Nieswandt B, et al. Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). Thromb Haemost. 2015;113:870-80 pubmed publisher
    Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis...
  20. Alibardi L. Ultrastructural immunolocalization of hyaluronate in regenerating tail of lizards and amphibians supports an immune-suppressive role to favor regeneration. J Morphol. 2017;: pubmed publisher
    ..tail blastemas has been assessed by ultrastructural immunolocalization of the Hyaluronate Binding Protein (HABP), a protein that indirectly reveals the presence of hyaluronate in tissues...
  21. Scherlag B, Papaila A. Permanent His bundle pacing to replace biventricular pacing for cardiac resynchronization therapy. Med Hypotheses. 2017;109:77-79 pubmed publisher
    ..Corollary 1. Permanent, selective, His bundle pacing (PHBP) is the most physiological form of ventricular pacing which replicates the normal activation of the ..
  22. Parahuleva M, Kanse S, Parviz B, Barth A, Tillmanns H, Bohle R, et al. Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques. Atherosclerosis. 2008;196:164-71 pubmed
    The Factor Seven Activating Protease (FSAP) is known to influence fibrinolysis and to play a critical role in the inhibition of vascular smooth muscle cell (VSMC) proliferation and migration as well as neointima formation...
  23. Rodríguez D, Ocampo M, Varela Y, Curtidor H, Patarroyo M, Patarroyo M. Mce4F Mycobacterium tuberculosis protein peptides can inhibit invasion of human cell lines. Pathog Dis. 2015;73: pubmed publisher
    ..38373 ((81)HMRLNSGTAIPSNVTATVRSY(100)) and 38379 ((201)IDQAGPFLQAQIRAGGDIKSY(220)) showed to be HABP and inhibited mycobacterial entry to A549 cells and peptide 38382 ((261)RPSFPALAASLANLGRVGVIY(280)) bind to U937 ..
  24. Tomsic J, Fultz R, Liyanarachchi S, He H, Senter L, de la Chapelle A. HABP2 G534E Variant in Papillary Thyroid Carcinoma. PLoS ONE. 2016;11:e0146315 pubmed publisher
    ..It was therefore of considerable interest that a mutation in the HABP2 gene was recently implicated in familial PTC...
  25. Altincicek B, Shibamiya A, Trusheim H, Tzima E, Niepmann M, Linder D, et al. A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding. Biochem J. 2006;394:687-92 pubmed
    b>FSAP (Factor VII-activating protease) is a novel plasma-derived serine protease that regulates haemostasis as well as vascular cell proliferation...
  26. McKinnell J, Corman S, Patel D, Leung G, Gordon L, Lodise T. Effective Antimicrobial Stewardship Strategies for Cost-effective Utilization of Telavancin for the Treatment of Patients With Hospital-acquired Bacterial Pneumonia Caused by Staphylococcus aureus. Clin Ther. 2018;40:406-414.e2 pubmed publisher
    ..compared with vancomycin (VAN) for patients with Staphylococcus aureus (SA) hospital-acquired bacterial pneumonia (HABP). This decision-analytic model assessed the treatment of SA-HABP with TLV versus VAN...
  27. Etscheid M, Subramaniam S, Lochnit G, Zabczyk M, Undas A, Lang I, et al. Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP). Biochim Biophys Acta Mol Basis Dis. 2018;: pubmed publisher
    b>Factor VII Activating Protease (FSAP) is a plasma protease affecting both coagulation and fibrinolysis...
  28. Kanse S, Declerck P, Ruf W, Broze G, Etscheid M. Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol. 2012;32:427-33 pubmed publisher
    Factor VII-activating protease (FSAP) activates both factor VII and pro-urokinase and inhibits platelet-derived growth factor-BB, thus regulating hemostasis- and remodeling-associated processes in the vasculature...
  29. Opheim L, Hellman U, Engström Laurent A, Laurent C. Hyaluronan in Human Vocal Folds in Smokers and Nonsmokers-A Histochemical Study. J Voice. 2016;30:255-62 pubmed publisher
    ..A direct method for hyaluronan histochemistry using a hyaluronan-binding protein probe (HABP) was used to visualize the polysaccharide...
  30. Shan P, Su L, Zhou X, Wu S, Xu L, Xiao F, et al. Beneficial effects of upgrading to His bundle pacing in chronically paced patients with left ventricular ejection fraction <50. Heart Rhythm. 2018;15:405-412 pubmed publisher
    ..The purpose of this study was to assess clinical outcomes of upgrading to permanent His bundle pacing (pHBP) in patients with heart failure who underwent device upgrade from right ventricular pacing or CRT nonresponse...
  31. Sedding D, Daniel J, Muhl L, Hersemeyer K, Brunsch H, Kemkes Matthes B, et al. The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. J Exp Med. 2006;203:2801-7 pubmed
    The G534E polymorphism (Marburg I [MI]) of factor VII-activating protease (FSAP) is associated with carotid stenosis and cardiovascular disease...
  32. Pecheniuk N, Elias D, Xu X, Griffin J. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry. Thromb Haemost. 2008;99:453-5 pubmed publisher
  33. Lanktree M, Johansen C, Anand S, Davis A, Miller R, Yusuf S, et al. Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration. Blood. 2010;116:2160-3 pubmed publisher
    ..The protein products of 2 of these loci, hyaluronan binding protein 2 (HABP2) and hyaluronoglucosaminidase 1 (HYAL1), play key roles in hyaluronan metabolism, providing ..
  34. Etscheid M, Muhl L, Pons D, Jukema J, Konig H, Kanse S. The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity. Thromb Res. 2012;130:935-41 pubmed publisher
    b>Factor VII activating protease (FSAP) is a plasma protease with FVII and pro-urokinase (pro-uPA) activating properties...
  35. Borkham Kamphorst E, Zimmermann H, Gassler N, Bissels U, Bosio A, Tacke F, et al. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J Hepatol. 2013;58:104-11 pubmed publisher
    b>Factor VII activating protease (FSAP) is a circulating serine protease produced in the liver...
  36. Alzahrani A, Murugan A, Qasem E, Al Hindi H. HABP2 Gene Mutations Do Not Cause Familial or Sporadic Non-Medullary Thyroid Cancer in a Highly Inbred Middle Eastern Population. Thyroid. 2016;26:667-71 pubmed publisher
    ..Recently, a c.1601G>A, p.G534E mutation in the HABP2 gene was reported to be the underlying genetic defect in a family with seven members affected by NMTC...
  37. Bohórquez M, Estrada A, Stultz J, Sahasrabudhe R, Williamson J, Lott P, et al. The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics. Endocr Connect. 2016;5:123-7 pubmed publisher
    ..Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC...
  38. Díaz D, Ocampo M, Pabón L, Herrera C, Patarroyo M, Munoz M, et al. Mycobacterium tuberculosis PE9 protein has high activity binding peptides which inhibit target cell invasion. Int J Biol Macromol. 2016;86:646-55 pubmed publisher
    ..b>HABP 39232 inhibited mycobacterial entry to A549 cells (∼70%) and U937 cells (∼50%), peptides 39226 and 39231 ..
  39. Tan G, Li W, Cheng J, Wang Z, Wei S, Jin Y, et al. Magnetic iron oxide modified pyropheophorbide-a fluorescence nanoparticles as photosensitizers for photodynamic therapy against ovarian cancer (SKOV-3) cells. Photochem Photobiol Sci. 2016;15:1567-1578 pubmed
    ..modified pyropheophorbide-a fluorescence nanoparticles, Fe3O4@SiO2@APTES@PPa (FSAP), were designed as magnetically targeted photodynamic antineoplastic agents and prepared through continuous ..
  40. Díaz D, Ocampo M, Varela Y, Curtidor H, Patarroyo M, Patarroyo M. Identifying and characterising PPE7 (Rv0354c) high activity binding peptides and their role in inhibiting cell invasion. Mol Cell Biochem. 2017;430:149-160 pubmed publisher
    ..b>HABP 39224 inhibited invasion in A549 epithelial cells and U937 macrophages by more than 50%, whilst HABP 39225 ..
  41. Weisbach V, Ruppel R, Eckstein R. The Marburg I polymorphism of factor VII-activating protease and the risk of venous thromboembolism. Thromb Haemost. 2007;97:870-2 pubmed
  42. de Jong H, Koh G, Bulder I, Stephan F, Wiersinga W, Zeerleder S. Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis). J Thromb Haemost. 2015;13:41-6 pubmed publisher
    The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from late apoptotic cells...
  43. Sun Y, Keller K. Hyaluronan cable formation by ocular trabecular meshwork cells. Exp Eye Res. 2015;139:97-107 pubmed publisher
    ..HA structural configuration was investigated by HA binding protein (HAbp) staining and confocal microscopy...
  44. An J, Wolke J, Jansen J, Leeuwenburgh S. Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements. J Mater Sci Mater Med. 2016;27:58 pubmed publisher
    ..e. hyaluronan-bisphosphonate (HABP)...
  45. Daniel J, Reichel C, Schmidt Woell T, Dutzmann J, Zuchtriegel G, Krombach F, et al. Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation. J Thromb Haemost. 2016;14:2058-2067 pubmed publisher
    Essentials Factor VII-activating protease (FSAP) is a plasma protease involved in vascular processes. Neointima formation was investigated after vascular injury in FSAP-/- mice...
  46. Peiling Yang S, Ngeow J. Familial non-medullary thyroid cancer: unraveling the genetic maze. Endocr Relat Cancer. 2016;23:R577-R595 pubmed
    ..1 gene (14q13), FOXE1 gene (9q22.33) and HABP2 gene (10q25.3)), out of which only the FOXE1 and the HABP2 genes have been validated by separate study groups...
  47. Choi Miura N, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, et al. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. J Biochem. 1996;119:1157-65 pubmed
    A novel hyaluronan-binding protein (PHBP) was purified from human plasma by affinity chromatography on hyaluronan-conjugated Sepharose...
  48. Römisch J. Factor VII activating protease (FSAP): a novel protease in hemostasis. Biol Chem. 2002;383:1119-24 pubmed
    Recently a novel serine protease in human plasma was described and was named PHBP, PHBSP or factor seven activating protease (FSAP), respectively, the latter according to the finding that it can support coagulation by factor VII ..
  49. Sidelmann J, Vitzthum F, Funding E, Münster A, Gram J, Jespersen J. Factor VII-activating protease in patients with acute deep venous thrombosis. Thromb Res. 2008;122:848-53 pubmed publisher
    Factor VII-activating protease (FSAP) is involved in haemostasis and inflammation. FSAP cleaves single chain urokinase-type plasminogen activator (scu-PA)...
  50. Baty F, Klingbiel D, Zappa F, Brutsche M. High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA). J Biomed Inform. 2015;58:175-185 pubmed publisher
    ..Splicing candidates reveal a series of genes related to carcinogenesis (SFTPB), cell adhesion (STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (..
  51. Duncan L, Smart J, Flamm R, Sader H, Jones R, Mendes R. Telavancin activity tested against a collection of Staphylococcus aureus isolates causing pneumonia in hospitalized patients in the United States (2013-2014). Diagn Microbiol Infect Dis. 2016;86:300-302 pubmed publisher
    Telavancin is approved in the United States and Europe for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia caused by Staphylococcus aureus...
  52. Chauhan G, Debette S. Genetic Risk Factors for Ischemic and Hemorrhagic Stroke. Curr Cardiol Rep. 2016;18:124 pubmed
    ..and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2)...
  53. Tai Z, Huang L, Lu F, Shi Y, Ma S, Cheng J, et al. Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population. BMC Med Genet. 2017;18:69 pubmed publisher
    ..Meanwhile, the coding regions of two genes, COL10A1 and HABP2, which may involve in the pathological mechanism of OA/KBD, were sequenced by Sanger sequencing to identify ..
  54. Parahuleva M, Jung J, Burgazli M, Erdogan A, Parviz B, Hölschermann H. Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages. Eur Rev Med Pharmacol Sci. 2016;20:2174-82 pubmed
    ..vascular pathophysiology, we have investigated the effect of vitamin C on the tissue factor (TF) and Factor VII Activating Protease (FSAP) expression induced by lipopolysaccharide (LPS) in human monocyte-derived macrophages...
  55. Colombo C, Fugazzola L, Muzza M, Proverbio M, Cirello V. Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern et al. Eur J Med Genet. 2018;61:104-105 pubmed publisher
    This Journal recently published a study (Kern et al., 2017) reporting the genetic analysis of the whole HABP2 gene in 11 independent kindreds with familial non medullary thyroid cancer (FNMTC). The Authors showed that a new variant (p...
  56. Wach A, Dembowsky K, Dale G. Pharmacokinetics and Safety of Intravenous Murepavadin Infusion in Healthy Adult Subjects Administered Single and Multiple Ascending Doses. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..aeruginosa Murepavadin is being developed for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP)...
  57. Anton A, Gonzalez Conejero R, Roldan V, Quiroga T, Sanchez Vega B, Corral J, et al. Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders. Ann Hematol. 2010;89:1147-54 pubmed publisher
    ..24; 95% CI, 0.11-0.52), supporting the polygenic nature of MCB. Our data suggest that some common polymorphisms affecting hemostasis-related genes could protect from bleeding. ..
  58. Kanse S, Gallenmueller A, Zeerleder S, Stephan F, Rannou O, Denk S, et al. Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a. J Immunol. 2012;188:2858-65 pubmed publisher
    ..In this context, little is known about factor VII-activating protease (FSAP), which is activated by substances released from damaged cells such as histones and nucleosomes...
  59. Wygrecka M, Morty R, Markart P, Kanse S, Andreasen P, Wind T, et al. Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome. J Biol Chem. 2007;282:21671-82 pubmed
    Factor VII-activating protease (FSAP) is a novel plasma-derived serine protease structurally homologous to tissue-type and urokinase-type plasminogen activators...
  60. Hanson E, Kanse S, Joshi A, Jood K, Nilsson S, Blomstrand C, et al. Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke. J Thromb Haemost. 2012;10:848-56 pubmed publisher
    Factor VII-activating protease (FSAP) is a recently discovered plasma protease with a role in the regulation of hemostasis and vascular remodeling processes...
  61. Parahuleva M, Maj R, Hölschermann H, Parviz B, Abdallah Y, Erdogan A, et al. Regulation of monocyte/macrophage function by factor VII activating protease (FSAP). Atherosclerosis. 2013;230:365-72 pubmed publisher
    b>Factor VII activating protease (FSAP) is a novel regulator of vascular inflammation and hemostasis...
  62. Liaw P, Ito T, Iba T, Thachil J, Zeerleder S. DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC. Blood Rev. 2016;30:257-61 pubmed publisher
    ..is a highly regulated process mediated among others by serine proteases, such as factor VII-activating protease (FSAP) and DNase1...
  63. Zhang T, Xing M. HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer. J Natl Cancer Inst. 2016;108:djv415 pubmed publisher
    ..No general susceptibility gene is known for FNMTC. An oncogenic HABP2 G534E mutation has been recently reported in one FNMTC kindred, suggesting that HABP2 is a susceptibility gene for ..
  64. Ng M, Graff M, Lu Y, Justice A, Mudgal P, Liu C, et al. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017;13:e1006719 pubmed publisher
    ..In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P < 5×10-8: seven for BMI, and one for WHRadjBMI in ..
  65. Li S, Shi C, Li Y, Li F, Tang M, Liu X, et al. Association of GWAS-Reported Variant rs11196288 near HABP2 with Ischemic Stroke in Chinese Han Population. J Mol Neurosci. 2017;62:209-214 pubmed publisher
    ..3 (rs11196288, near HABP2) associated with the risk of early-onset ischemic stroke (IS) in European population, but not with late-onset IS...
  66. Kara E, Manna D, Løset G, Schneider E, Craik C, Kanse S. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost. 2017;117:1750-1760 pubmed publisher
    Factor VII (FVII) activating protease (FSAP) is a circulating serine protease that is likely to be involved in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer...
  67. Wang K, Liu N, Radulovich N, Wigle D, Johnston M, Shepherd F, et al. Novel candidate tumor marker genes for lung adenocarcinoma. Oncogene. 2002;21:7598-604 pubmed
    ..Among these genes, overexpression of Lc19, hyaluronan binding protein 2 (HABP2) and crystalline-mu appeared more specific to adenocarcinoma, whereas ceruloplasmin, integrin ..
  68. Muhl L, Hersemeyer K, Preissner K, Weimer T, Kanse S. Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions. FEBS Lett. 2009;583:1994-8 pubmed publisher
    b>Factor VII activating protease (FSAP) is associated with cardiovascular diseases and liver fibrosis. To understand the regulation of its proteolytic activity we have characterized recombinant FSAP-mutants over-expressed in HEK-293 cells...
  69. Tan Q, Tang H, Liu R, Wang G, Yang X, Chen F. [Marburg I polymorphism of Factor VII-activating protease and cerebral infarction]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:1171-5 pubmed
    To determine the relation between Marburg I polymorphism of Factor VII-activating protease (FSAP) and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction...
  70. Kanse S, Etscheid M. Factor VII activating protease. Single nucleotide polymorphisms light the way. Hamostaseologie. 2011;31:174-6, 177-8 pubmed publisher
    b>Factor VII activating protease (FSAP) is a circulating serine protease with high homology to fibrinolytic enzymes...
  71. Roedel E, Schwarz E, Kanse S. The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2). J Biol Chem. 2013;288:7193-203 pubmed publisher
    Factor VII-activating protease (FSAP) is a circulating protease involved in the pathogenesis of atherosclerosis, calcification, and fibrotic processes...
  72. Parahuleva M, Kanse S, Hölschermann H, Zheleva K, Zandt D, Worsch M, et al. Association of circulating factor seven activating protease (FSAP) and of oral Omega-3 fatty acids supplements with clinical outcome in patients with atrial fibrillation: the OMEGA-AF study. J Thromb Thrombolysis. 2014;37:317-25 pubmed publisher
    b>Factor VII Activating Protease (FSAP) activates factor VII (FVII) as well as pro-urokinase (uPA)...
  73. Sahasrabudhe R, Stultz J, Williamson J, Lott P, Estrada A, Bohorquez M, et al. The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer. J Clin Endocrinol Metab. 2016;10:1098-1103 pubmed publisher
    A recent study reported the non-synonymous G534E (rs7080536, allele A) variant in the HABP2 gene as causal in familial non-medullary thyroid cancer (NMTC)...
  74. Weeks A, Wilson S, Ward L, Goldblatt J, Hui J, Walsh J. HABP2 germline variants are uncommon in familial nonmedullary thyroid cancer. BMC Med Genet. 2016;17:60 pubmed publisher
    ..A recent study identified HABP2 as a tumor suppressor gene and identified a germline variant (G534E) in an extended FNMTC kindred...
  75. Wilson S, Graham D, Wang W, Bruss J, Castaneda Ruiz B. Telavancin in the Treatment of Concurrent Staphylococcus aureus Bacteremia: A Retrospective Analysis of ATLAS and ATTAIN Studies. Infect Dis Ther. 2017;6:413-422 pubmed publisher
    ..structure infections (cSSSI), hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia (HABP/VABP). These challenges highlight the need for alternative treatments...
  76. Sperling C, Maitz M, Grasso S, Werner C, Kanse S. A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP). ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..Because Factor VII activating protease (FSAP) is known to be activated on positively and on negatively charged macromolecules in plasma, we ..
  77. Choi Miura N, Yoda M, Saito K, Takahashi K, Tomita M. Identification of the substrates for plasma hyaluronan binding protein. Biol Pharm Bull. 2001;24:140-3 pubmed
    Plasma hyaluronan biding protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen ..
  78. Martínez Palacián A, Kanse S, Weiskirchen R. Factor VII activating protease (FSAP): a novel protective factor in liver fibrosis. Proteomics Clin Appl. 2014;8:438-46 pubmed publisher
    b>Factor VII activating protease (FSAP) is a multifunctional serine protease that is mainly synthesized and secreted by hepatocytes...
  79. Stavenuiter F, Ebberink E, Mertens K, Meijer A. Role of glycine 221 in catalytic activity of hyaluronan-binding protein 2. J Biol Chem. 2017;292:6381-6388 pubmed publisher
    b>HABP2 (hyaluronan-binding protein 2) is a Ca2+-dependent serine protease with putative roles in blood coagulation and fibrinolysis...
  80. Walker J, Theriot B, Ghio M, Trempus C, Wong J, McQuade V, et al. Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease. Am J Respir Cell Mol Biol. 2017;57:702-710 pubmed publisher
    ..Lung sections were stained using antibodies specific for HA-binding protein (HABP) and ?-SMA, as well as Masson's trichrome stain...
  81. Grasso S, Neumann A, Lang I, Etscheid M, von Köckritz Blickwede M, Kanse S. Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs). Thromb Res. 2018;161:36-42 pubmed publisher
    The circulating zymogen form of Factor VII activating protease (FSAP) can be activated by histones and nucleosomes in vivo...
  82. Gara S, Jia L, Merino M, Agarwal S, Zhang L, Cam M, et al. Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. N Engl J Med. 2015;373:448-55 pubmed publisher
    ..Here, we report a germline variant of HABP2 in seven affected members of a kindred with familial nonmedullary thyroid cancer and in 4...
  83. Kern B, Coppin L, Romanet P, Crepin M, Szuster I, Renaud F, et al. Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls. Eur J Med Genet. 2017;60:178-184 pubmed publisher
    A heterozygous germline variant in the HABP2 gene c.1601G > A (p...
  84. Hamada S, Nishida Y, Zhuo L, Shinomura T, Ikuta K, Arai E, et al. Suppression of hyaluronan synthesis attenuates the tumorigenicity of low grade chondrosarcoma. J Orthop Res. 2017;: pubmed publisher
    ..HA binding protein (HABP) stainability on and around the RCS cells was effectively reduced with treatment of MU...
  85. Zhanel G, Lawrence C, Adam H, Schweizer F, Zelenitsky S, Zhanel M, et al. Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations. Drugs. 2018;78:65-98 pubmed publisher
    ..for the treatment of imipenem-resistant bacterial infections, as well as hospital-associated bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP)...
  86. Yamamichi S, Nishitani M, Nishimura N, Matsushita Y, Hasumi K. Polyamine-promoted autoactivation of plasma hyaluronan-binding protein. J Thromb Haemost. 2010;8:559-66 pubmed publisher
    Plasma hyaluronan-binding protein (PHBP), a protease implicated in extracellular proteolysis, consists of multiple domains: an N-terminal region (NTR), three epidermal growth factor (EGF)-like domains, a kringle domain, and a protease ..
  87. Bustamante A, Díaz Fernández B, Giralt D, Boned S, Pagola J, Molina C, et al. Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke. Int J Stroke. 2016;11:646-55 pubmed publisher
    ..b>Factor seven activating protease (FSAP) has been described to have a relevant pathophysiological role in stroke...
  88. Pinheiro M, Drigo S, Tonhosolo R, Andrade S, Marchi F, Jurisica I, et al. HABP2 p.G534E variant in patients with family history of thyroid and breast cancer. Oncotarget. 2017;8:40896-40905 pubmed publisher
    ..described as a hereditary predisposition cancer syndrome associated with mutations in candidate genes including HABP2. Two of 20 probands from families with history of PTC and breast carcinoma (BC) were evaluated by whole exome ..
  89. Byskov K, Boettger T, Ruehle P, Nielsen N, Etscheid M, Kanse S. Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells. Atherosclerosis. 2017;265:133-139 pubmed publisher
    The factor VII activating protease (FSAP) knockout mice have a bigger neointima after vascular injury and a larger infarct volume after stroke...
  90. Stergiopoulos S, Calvert S, Brown C, Awatin J, Tenaerts P, Holland T, et al. Cost Drivers of a Hospital Acquired Bacterial Pneumonia and Ventilator Associated Bacterial Pneumonia (HABP/VABP) Phase Three Clinical Trial. Clin Infect Dis. 2017;: pubmed publisher
    ..of multi-drug resistant infections, including hospital acquired and ventilator associated bacterial pneumonia (HABP/VABP), has been rising...
  91. van Minkelen R, de Visser M, Vos H, Bertina R, Rosendaal F. The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis. Blood. 2005;105:4898; author reply 4899 pubmed
  92. Sidelmann J, Skouby S, Kluft C, Winkler U, Vitzthum F, Schwarz H, et al. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo. Thromb Res. 2011;128:e67-72 pubmed publisher
    ..Factor VII-activating protease (FSAP) has potential effects on hemostasis...