Gene Symbol: H4
Description: histone cluster 2 H4 family member a
Alias: FO108, H4/n, H4F2, H4FN, HIST2H4, histone H4, H4 histone family, member N, H4 histone, family 2, histone 2, H4a, histone IV, family 2, histone cluster 2, H4a
Species: human
Products:     H4

Top Publications

  1. Seo S, McNamara P, Heo S, Turner A, Lane W, Chakravarti D. Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell. 2001;104:119-30 pubmed
    ..We propose that histone masking by INHAT plays a regulatory role in chromatin modification and serves as a novel mechanism of transcriptional regulation. ..
  2. Mallette F, Mattiroli F, Cui G, Young L, Hendzel M, Mer G, et al. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 2012;31:1865-78 pubmed publisher
    ..of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20...
  3. Botuyan M, Lee J, Ward I, Kim J, Thompson J, Chen J, et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006;127:1361-73 pubmed
    ..Here we demonstrate that this link occurs through direct binding of 53BP1 and Crb2 to histone H4. Using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, we show that, despite low amino ..
  4. Zhang Y, Sun Z, Iratni R, Erdjument Bromage H, Tempst P, Hampsey M, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998;1:1021-31 pubmed
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms. ..
  5. Verreault A, Kaufman P, Kobayashi R, Stillman B. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Curr Biol. 1998;8:96-108 pubmed
    In eukaryotic cells, newly synthesized histone H4 is acetylated at lysines 5 and 12, a transient modification erased by deacetylases shortly after deposition of histones into chromosomes...
  6. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  7. Bender S, Tang Y, Lindroth A, Hovestadt V, Jones D, Kool M, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell. 2013;24:660-72 pubmed publisher
  8. Plotnikov A, Yang S, Zhou T, Rusinova E, Frasca A, Zhou M. Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP. Structure. 2014;22:353-60 pubmed publisher
    ..of the bromodomain-PHD tandem module of human transcriptional coactivator CBP bound to lysine-acetylated histone H4 peptides...
  9. Tong Q, Mazur S, Rincón Arano H, Rothbart S, Kuznetsov D, Cui G, et al. An acetyl-methyl switch drives a conformational change in p53. Structure. 2015;23:322-31 pubmed publisher
    ..Our findings suggest a novel PTM-driven conformation switch-like mechanism that may regulate p53 interactions with binding partners. ..

More Information


  1. Weerapana E, Wang C, Simon G, Richter F, Khare S, Dillon M, et al. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature. 2010;468:790-5 pubmed publisher
  2. Lahn B, Tang Z, Zhou J, Barndt R, Parvinen M, Allis C, et al. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc Natl Acad Sci U S A. 2002;99:8707-12 pubmed
    ..It has long been thought that this process is facilitated by the hyperacetylation of histone H4. However, the responsible histone acetyltransferase enzymes are yet to be identified...
  3. Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B. Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2. FEBS Lett. 2010;584:3901-8 pubmed publisher
    ..mechanism for how the N-terminal bromodomain of human BRD2 (BRD2-BD1) deciphers the mono-acetylated status of histone H4 tail was recently reported...
  4. Wang C, Zhu Y, Caceres T, Liu L, Peng J, Wang J, et al. Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7. Structure. 2014;22:756-68 pubmed publisher
    ..the crystal structure of the TbPRMT7 active core in complex with S-adenosyl-L-homocysteine (AdoHcy) and a histone H4 peptide substrate...
  5. Chodaparambil J, Pate K, Hepler M, Tsai B, Muthurajan U, Luger K, et al. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014;33:719-31 pubmed publisher
    ..Furthermore, the TLE Q tetramer, not the dimer, binds to chromatin, specifically to K20 methylated histone H4 tails, suggesting that the TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate ..
  6. Conn K, Hendzel M, Schang L. Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1. J Virol. 2011;85:13234-52 pubmed publisher
    ..We therefore evaluated the mobility of the core histones H2B and H4 as measures of the mobilization of H2A-H2B dimers and the more stable H3-H4 core tetramer...
  7. Pivot Pajot C, Caron C, Govin J, Vion A, Rousseaux S, Khochbin S. Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. Mol Cell Biol. 2003;23:5354-65 pubmed
    ..BRDT specifically binds hyperacetylated histone H4 tail depending on the integrity of both bromodomains...
  8. Wang Y, Wang J, Li G. Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. FEBS Lett. 2006;580:3787-93 pubmed
  9. Rodriguez P, Munroe D, Prawitt D, Chu L, Bric E, Kim J, et al. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Genomics. 1997;44:253-65 pubmed
    ..Our results, coupled with tumor suppression assays in G401 WT cells, do not support a role for NAP-2 in the etiology of WT. A putative role for NAP-2 in regulating cellular differentiation is discussed. ..
  10. Wang Y, Wysocka J, Sayegh J, Lee Y, Perlin J, Leonelli L, et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004;306:279-83 pubmed
    ..PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3)...
  11. Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, et al. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell. 2013;155:1581-1595 pubmed publisher
    ..The functions of JMJD6/ Brd4-associated dual histone and RNA demethylase activity on anti-pause enhancers have intriguing implications for these proteins in development, homeostasis, and disease. ..
  12. Alenghat T, Yu J, Lazar M. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. EMBO J. 2006;25:3966-74 pubmed
    ..SNF2H does not interact directly with the N-CoR/HDAC3 complex, but binds to unacetylated histone H4 tails, suggesting that deacetylase activity of the corepressor complex is critical to SNF2H function...
  13. Liokatis S, Edlich C, Soupsana K, Giannios I, Panagiotidou P, Tripsianes K, et al. Solution structure and molecular interactions of lamin B receptor Tudor domain. J Biol Chem. 2012;287:1032-42 pubmed publisher
    ..The Ser-Arg region, alone or in combination with LBR-TD, binds both unassembled and assembled H3/H4 histones, suggesting that the TD/RS interface may operate as a "histone chaperone-like platform."
  14. Revenko A, Kalashnikova E, Gemo A, Zou J, Chen H. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010;30:5260-72 pubmed publisher
    ..Together, these results suggest that ANCCA acts as a pioneer factor in E2F-dependent gene activation and that a novel mechanism involving ANCCA bromodomain may contribute to cancer cell proliferation. ..
  15. Carrier F, Georgel P, Pourquier P, Blake M, Kontny H, Antinore M, et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol. 1999;19:1673-85 pubmed
    ..Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins. ..
  16. Shiio Y, Eisenman R. Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A. 2003;100:13225-30 pubmed
    ..Here we report that histone H4 is modified by small ubiquitin-related modifier (SUMO) family proteins both in vivo and in vitro...
  17. Mitra P, Xie R, Medina R, Hovhannisyan H, Zaidi S, Wei Y, et al. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol. 2003;23:8110-23 pubmed
    ..characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family...
  18. Trojer P, Li G, Sims R, Vaquero A, Kalakonda N, Boccuni P, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell. 2007;129:915-28 pubmed
    ..this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26...
  19. Huo T, Canepa R, Sura A, Modave F, Gong Y. Colorectal cancer stages transcriptome analysis. PLoS ONE. 2017;12:e0188697 pubmed publisher
    ..This study identified a small number of genes that might be associated with clinical stages of CRC. Our analysis was not able to find a molecular basis for the current clinical staging for CRC based on the gene expression patterns...
  20. Hagiwara T, Hidaka Y, Yamada M. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. Biochemistry. 2005;44:5827-34 pubmed
    ..Immunoblotting using antimodified citrulline antibody indicated that histones H2A, H3, and H4 but not H2B were deiminated...
  21. Vermeulen M, Mulder K, Denissov S, Pijnappel W, van Schaik F, Varier R, et al. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell. 2007;131:58-69 pubmed
    ..Our experiments reveal crosstalk between histone modifications and the transcription factor TFIID. This has important implications for regulation of RNA polymerase II-mediated transcription in higher eukaryotes. ..
  22. Aggarwal P, Vaites L, Kim J, Mellert H, Gurung B, Nakagawa H, et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010;18:329-40 pubmed publisher
    ..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity. ..
  23. Cereseto A, Manganaro L, Gutierrez M, Terreni M, Fittipaldi A, Lusic M, et al. Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J. 2005;24:3070-81 pubmed
    ..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification. ..
  24. Buggy J, Sideris M, Mak P, Lorimer D, McIntosh B, Clark J. Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem J. 2000;350 Pt 1:199-205 pubmed
    ..immunopurified HDAC8 is shown to possess trichostatin A- and sodium butyrate-inhibitable HDAC activity on histone H4 peptide substrates as well as on core histones...
  25. Kimura A, Horikoshi M. Tip60 acetylates six lysines of a specific class in core histones in vitro. Genes Cells. 1998;3:789-800 pubmed
    ..sites for Tip60 are the Lys-5 of histone H2A, the Lys-14 of histone H3, and the Lys-5, -8, -12, -16 of histone H4, determined by a method which combined matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) ..
  26. Haas A, Bright P, Jackson V. Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation. J Biol Chem. 1988;263:13268-75 pubmed
    ..to catalyze the E3-independent conjugation of ubiquitin to linker histone H1 and core histones H2A, H2B, H3, and H4 in the presence of catalytic amounts of E1...
  27. Kim J, Roeder R. Nucleosomal H2B ubiquitylation with purified factors. Methods. 2011;54:331-8 pubmed publisher
  28. Hovhannisyan H, Cho B, Mitra P, Montecino M, Stein G, Van Wijnen A, et al. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. Mol Cell Biol. 2003;23:1460-9 pubmed
    ..To address the mechanism by which this regulation occurs, we examined the chromatin structure of the histone H4/n (FO108, H4FN) gene locus...
  29. Kzhyshkowska J, Rusch A, Wolf H, Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem J. 2003;371:385-93 pubmed
    ..We found that, although BRD7 binds to histones H2A, H2B, H3 and H4 through its bromodomain, this domain was not necessary for the interaction with E1B-AP5...
  30. Pelicci G, Lanfrancone L, Salcini A, Romano A, Mele S, Grazia Borrello M, et al. Constitutive phosphorylation of Shc proteins in human tumors. Oncogene. 1995;11:899-907 pubmed
    ..Some of the Shc-associated phosphoproteins (EGFR, PDGFR, erbB-2, Met, bcr-abl, H4-ret) bound both the Shc- and Grb2-SH2 domains in vitro; others (p175; p70-p80) only the Shc-SH2 domain and yet ..
  31. Aziz F, van Wijnen A, Vaughan P, Wu S, Shakoori A, Lian J, et al. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. Mol Biol Rep. 1998;25:1-12 pubmed
    Maximal transcription of a prototypical cell cycle controlled histone H4 gene requires a proliferation-specific in vivo genomic protein/DNA interaction element, Site II...
  32. Díaz Jullien C, Pérez Estévéz A, Covelo G, Freire M. Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. Biochim Biophys Acta. 1996;1296:219-27 pubmed
    ..and histones in solution) indicated that Pro T alpha has higher affinity for core histones (particularly H3 and H4) than for H1...
  33. Yang F, Sun L, Li Q, Han X, Lei L, Zhang H, et al. SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J. 2012;31:110-23 pubmed publisher
  34. Fradet Turcotte A, Canny M, Escribano Diaz C, Orthwein A, Leung C, Huang H, et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 2013;499:50-4 pubmed publisher
    ..How ubiquitin recruits 53BP1 to break sites remains unknown as its relocalization involves recognition of histone H4 Lys?20 (H4K20) methylation by its Tudor domain...
  35. Pauli U, Chrysogelos S, Stein G, Stein J, Nick H. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. Science. 1987;236:1308-11 pubmed
    ..Protein-DNA interactions in the 5' promoter region of a cell cycle-regulated human H4 histone gene have been analyzed at single-nucleotide resolution in vivo...
  36. Sims J, Rice J. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Mol Cell Biol. 2008;28:4459-68 pubmed publisher
    ..We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysine 9 (H3K9); however, the mechanisms that establish this code and its function in ..
  37. Kanno T, Kanno Y, Siegel R, Jang M, Lenardo M, Ozato K. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell. 2004;13:33-43 pubmed
    ..The bromodomain protein Brd2 selectively interacted with acetylated lysine 12 on histone H4, whereas TAF(II)250 and PCAF recognized H3 and other acetylated histones, indicating fine specificity of histone ..
  38. Zhang Y, Griffin K, Mondal N, Parvin J. Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem. 2004;279:21866-72 pubmed
    ..These results suggest that acetylation of histones may stimulate transcription by suppressing an inhibitory phosphorylation by a kinase as MSK1. ..
  39. Lubula M, Eckenroth B, Carlson S, Poplawski A, Chruszcz M, Glass K. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett. 2014;588:3844-54 pubmed publisher
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  40. Kovalsky O, Lung F, Roller P, Fornace A. Oligomerization of human Gadd45a protein. J Biol Chem. 2001;276:39330-9 pubmed
    ..Evidence for a potential role of Gadd45a self-association in altering DNA accessibility on damaged nucleosomes is presented. ..
  41. Yoon H, Chan D, Huang Z, Li J, Fondell J, Qin J, et al. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 2003;22:1336-46 pubmed
    ..In vitro, TBL1/TBLR1 bind histones H2B and H4, and, importantly, repression by TBL1/TBLR1 correlates with their interaction with histones...
  42. Amente S, Napolitano G, Licciardo P, Monti M, Pucci P, Lania L, et al. Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. FEBS Lett. 2005;579:683-9 pubmed
    ..We found that FCP1 is a genuine substrate of PRMT5-methylation both in vivo and in vitro, and FCP1-associated PRMT5 can methylate histones H4 in vitro.
  43. Sierra F, Stein G, Stein J. Structure and in vitro transcription of a human H4 histone gene. Nucleic Acids Res. 1983;11:7069-86 pubmed
    A human H4 histone gene was isolated and the nucleotide sequences of the mRNA coding as well as the 5' and 3' flanking regions were determined. No intervening sequences were found in this gene...
  44. Kalakonda N, Fischle W, Boccuni P, Gurvich N, Hoya Arias R, Zhao X, et al. Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. Oncogene. 2008;27:4293-304 pubmed publisher
    ..reported that the 3xMBT repeats interact with mono- and dimethylated lysines in the amino termini of histones H4 and H1b to promote methylation-dependent chromatin compaction...
  45. Lacroix M, El Messaoudi S, Rodier G, Le Cam A, Sardet C, Fabbrizio E. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. EMBO Rep. 2008;9:452-8 pubmed publisher
    ..PRMT5 bound to COPR5 methylates histone H4 (R3) preferentially when compared with histone H3 (R8), suggesting that COPR5 modulates the substrate ..
  46. Mavrakis K, McDonald E, Schlabach M, Billy E, Hoffman G, deWeck A, et al. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science. 2016;351:1208-13 pubmed publisher
    ..Inhibitors of PRMT5 that leverage this dysregulated metabolic state merit further investigation as a potential therapy for MTAP/CDKN2A-deleted tumors. ..
  47. Green L, van Antwerpen R, Stein J, Stein G, Tripputi P, Emanuel B, et al. A major human histone gene cluster on the long arm of chromosome 1. Science. 1984;226:838-40 pubmed
    ..1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32P-labeled cloned human H4 and H3 histone DNA as probes...
  48. Tong Q, Cui G, Botuyan M, Rothbart S, Hayashi R, Musselman C, et al. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure. 2015;23:312-21 pubmed publisher
  49. Ooi S, Qiu C, Bernstein E, Li K, Jia D, Yang Z, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007;448:714-7 pubmed
    ..These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2. ..
  50. Braastad C, Hovhannisyan H, Van Wijnen A, Stein J, Stein G. Functional characterization of a human histone gene cluster duplication. Gene. 2004;342:35-40 pubmed
    ..Levels of messenger RNAs for duplicated histone H4 genes are high relative to those for non-duplicated H4 genes...
  51. Antonysamy S, Bonday Z, Campbell R, Doyle B, Druzina Z, Gheyi T, et al. Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A. 2012;109:17960-5 pubmed publisher
    ..MEP50 (methylosome protein 50), bound to an S-adenosylmethionine analog and a peptide substrate derived from histone H4. The structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed ..
  52. Liu Y, Wang X, Zhang J, Huang H, Ding B, Wu J, et al. Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails. Biochemistry. 2008;47:6403-17 pubmed publisher
    ..With its tandem bromodomains, Brd4 avidly binds to diacetylated H4-AcK5/K12 and H3-AcK9/K14 peptides. Solution structure of the second bromodomain (BD) is reported in this research...
  53. Ansari K, Mishra B, Mandal S. Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Biochim Biophys Acta. 2008;1779:66-73 pubmed
    ..These results demonstrated that CGBP interacts with MLL1, MLL2 as well as hSet1 HMTs and plays critical roles in regulations of MLL target genes. ..
  54. Cook A, Gurard Levin Z, Vassias I, Almouzni G. A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain. Mol Cell. 2011;44:918-27 pubmed publisher
    ..that the histone chaperone nuclear autoantigenic sperm protein (NASP) protects a reservoir of soluble histones H3-H4. The importance of NASP is revealed upon histone overload, engagement of the reservoir during acute replication ..
  55. Zhai N, Zhao Z, Cheng M, Di Y, Yan H, Cao C, et al. Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. J Mol Cell Biol. 2012;4:231-41 pubmed publisher
    ..Here, we show that human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes...
  56. Tang J, Cho N, Cui G, Manion E, Shanbhag N, Botuyan M, et al. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol. 2013;20:317-25 pubmed publisher
    ..sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 53BP1, which binds histone H4 dimethylated at Lys20 (H4K20me2) to promote nonhomologous end joining, suggesting that a balance between BRCA1 ..
  57. Park S, Martinez Yamout M, Dyson H, Wright P. The CH2 domain of CBP/p300 is a novel zinc finger. FEBS Lett. 2013;587:2506-11 pubmed publisher
    ..We tested the hypothesis that the bromodomain and the CH2 domain can interact with histones, but found that the CH2 does not participate in histone-recognition. ..
  58. Min J, Allali Hassani A, Nady N, Qi C, Ouyang H, Liu Y, et al. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 2007;14:1229-30 pubmed
    Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides...
  59. Lee D, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup M. Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol. 2007;21:1381-93 pubmed
    ..coactivators, such as glucocorticoid receptor-interacting protein 1 (GRIP1), as well as its ability to methylate histone H4 and coactivators such as peroxisome proliferator-activated receptor gamma coactivator-1alpha...
  60. Ruthenburg A, Li H, Milne T, Dewell S, McGinty R, Yuen M, et al. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 2011;145:692-706 pubmed publisher
    ..Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations. ..
  61. Grozinger C, Hassig C, Schreiber S. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999;96:4868-73 pubmed
    ..However, HDAC4 and HDAC5 associate with HDAC3 in vivo. This finding suggests that the human class II HDAC enzymes may function in cellular processes distinct from those of HDAC1 and HDAC2. ..
  62. Elsässer S, Huang H, Lewis P, Chin J, Allis C, Patel D. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature. 2012;491:560-5 pubmed publisher
    ..3. Here we report the crystal structures of the DAXX histone-binding domain with a histone H3.3-H4 dimer, including mutants within DAXX and H3...
  63. Xiao B, Jing C, Kelly G, Walker P, Muskett F, Frenkiel T, et al. Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev. 2005;19:1444-54 pubmed
    ..the crystal structure of a ternary complex of the enzyme Pr-Set7 (also known as Set8) that methylates Lys 20 of histone H4 (H4-K20)...
  64. Coleman M, Miller K, Beernink P, Yoshikawa D, Albala J. Identification of chromatin-related protein interactions using protein microarrays. Proteomics. 2003;3:2101-7 pubmed
    ..This is the first demonstration of an interaction between RAD51B and histone proteins that may be important for the successful repair of DNA double-strand breaks. ..
  65. Kato K, Miyaji Yamaguchi M, Okuwaki M, Nagata K. Histone acetylation-independent transcription stimulation by a histone chaperone. Nucleic Acids Res. 2007;35:705-15 pubmed
    ..These results suggest that TAF-I remodel the chromatin structure through its interaction with the core domain of the histones, including the histone fold, and this mechanism is independent of the histone acetylation status. ..
  66. Murzina N, Pei X, Zhang W, Sparkes M, Vicente Garcia J, Pratap J, et al. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008;16:1077-85 pubmed publisher
    ..We report here the crystal structure of human RbAp46 bound to histone H4. RbAp46 folds into a seven-bladed beta propeller structure and binds histone H4 in a groove formed between an N-..
  67. Hoffmann A, Chiang C, Oelgeschlager T, Xie X, Burley S, Nakatani Y, et al. A histone octamer-like structure within TFIID. Nature. 1996;380:356-9 pubmed
    ..Together with analyses of native TFIID complexes and accompanying crystallographic studies, the results suggest that there is a histone octamer-like TAF complex within TFIID. ..
  68. Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, et al. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev. 2011;25:901-6 pubmed publisher
    ..The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer...