H3

Summary

Gene Symbol: H3
Description: histone cluster 2 H3 family member c
Alias: H3.2, H3/M, H3F2, H3FM, H3FN, histone H3.2, H3 histone family, member M, H3 histone, family 2, histone 2, H3c, histone H3/m, histone cluster 2, H3c
Species: human
Products:     H3

Top Publications

  1. Ooi S, Qiu C, Bernstein E, Li K, Jia D, Yang Z, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007;448:714-7 pubmed
    ..Peptide interaction assays showed that DNMT3L specifically interacts with the extreme amino terminus of histone H3; this interaction was strongly inhibited by methylation at lysine 4 of histone H3 but was insensitive to ..
  2. Nady N, Lemak A, Walker J, Avvakumov G, Kareta M, Achour M, et al. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J Biol Chem. 2011;286:24300-11 pubmed publisher
    ..hemimethylated CpG sites, which are specifically recognized through its SRA domain and also interacts with histone H3 trimethylated on lysine 9 (H3K9me3) in an unspecified manner...
  3. Dai J, Sultan S, Taylor S, Higgins J. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev. 2005;19:472-88 pubmed
    ..Thr 3 of histone H3 is highly conserved, but the significance of its phosphorylation is unclear, and the identity of the corresponding ..
  4. Garcia B, Hake S, Diaz R, Kauer M, Morris S, Recht J, et al. Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem. 2007;282:7641-55 pubmed publisher
    ..Using a combination of mass spectrometric and immunobiochemical approaches, we show that the PTM profile of histone H3 differs significantly among the various model organisms examined...
  5. Preuss U, Landsberg G, Scheidtmann K. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. Nucleic Acids Res. 2003;31:878-85 pubmed
    ..interacting protein (ZIP) kinase, is a nuclear serine/threonine-specific kinase that phosphorylates core histones H3 and H4, and myosine light chain in vitro...
  6. Goo Y, Sohn Y, Kim D, Kim S, Kang M, Jung D, et al. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol. 2003;23:140-9 pubmed
    ..a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities...
  7. Kang T, Park D, Choi Y, Kim K, Yoon H, Kim K. Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Mol Cell Biol. 2007;27:8533-46 pubmed
    ..In mammals, aurora B is believed to be the mitotic histone H3 Ser10 kinase; however, it is not sufficient to phosphorylate H3 Ser10 with aurora B alone...
  8. Lachner M, O Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001;410:116-20 pubmed
    ..Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules ..
  9. Hurd P, Bannister A, Halls K, Dawson M, Vermeulen M, Olsen J, et al. Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J Biol Chem. 2009;284:16575-83 pubmed publisher
    ..Here, we identify threonine 45 of histone H3 (H3T45) as a site of phosphorylation in vivo...

More Information

Publications91

  1. Wang H, Zhai L, Xu J, Joo H, Jackson S, Erdjument Bromage H, et al. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell. 2006;22:383-94 pubmed
    ..Here, we report the purification and functional characterization of a histone H3 and H4 ubiquitin ligase complex, CUL4-DDB-ROC1...
  2. Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, et al. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem. 1999;274:25543-9 pubmed
    Histone H3 (H3) phosphorylation at Ser(10) occurs during mitosis in eukaryotes and was recently shown to play an important role in chromosome condensation in Tetrahymena...
  3. Winter S, Simboeck E, Fischle W, Zupkovitz G, Dohnal I, Mechtler K, et al. 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J. 2008;27:88-99 pubmed
    Interphase phosphorylation of S10 at histone H3 is linked to transcriptional activation of a specific subset of mammalian genes like HDAC1. Recently, 14-3-3 proteins have been described as detectors for this phosphorylated histone H3 form...
  4. Peña P, Hom R, Hung T, Lin H, Kuo A, Wong R, et al. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol. 2008;380:303-12 pubmed publisher
    ..apoptotic activities of ING1 require the interaction of the C-terminal plant homeodomain (PHD) finger with histone H3 trimethylated at Lys4 (H3K4me3)...
  5. Kontopoulos E, Parvin J, Feany M. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet. 2006;15:3012-23 pubmed
    ..Alpha-synuclein binds directly to histones, reduces the level of acetylated histone H3 in cultured cells and inhibits acetylation in histone acetyltransferase assays...
  6. Li Y, Jaramillo Lambert A, Yang Y, Williams R, Lee N, Zhu W. And-1 is required for the stability of histone acetyltransferase Gcn5. Oncogene. 2012;31:643-52 pubmed publisher
    ..domain-containing protein) has remarkable capability to regulate the stability of Gcn5 proteins and thereby histone H3 acetylation. We find that And-1 forms a complex with both histone H3 and Gcn5...
  7. Wakeman T, Wang Q, Feng J, Wang X. Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. EMBO J. 2012;31:2169-81 pubmed publisher
    The methyltransferase DOT1L methylates histone H3 at K79 to facilitate specific biological events...
  8. Lan F, Collins R, De Cegli R, Alpatov R, Horton J, Shi X, et al. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007;448:718-22 pubmed
    ..LSD1 is a lysine-specific histone demethylase that represses transcription by demethylating histone H3 on lysine 4 (ref. 1)...
  9. Wu H, Zeng H, Lam R, Tempel W, Amaya M, Xu C, et al. Structural and histone binding ability characterizations of human PWWP domains. PLoS ONE. 2011;6:e18919 pubmed publisher
    ..Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1. ..
  10. Kang B, Pu M, Hu G, Wen W, Dong Z, Zhao K, et al. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. Genes Dev. 2011;25:1359-64 pubmed publisher
    Histone H3 variant H3.3, while differing from canonical H3 (H3.1) by only five amino acids, is assembled into nucleosomes, along with histone H4, at genic regions by the histone chaperone HIRA, whereas H3...
  11. Shikama N, Chan H, Krstic Demonacos M, Smith L, Lee C, Cairns W, et al. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol. 2000;20:8933-43 pubmed
    ..These results argue that NAP is a functionally important component of the p300 coactivator complex and suggest that NAP may serve as a point of integration between transcriptional coactivators and chromatin. ..
  12. Lan L, Nakajima S, Kapetanaki M, Hsieh C, Fagerburg M, THICKMAN K, et al. Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. J Biol Chem. 2012;287:12036-49 pubmed publisher
    ..The partial eviction of H3 from the nucleosomes is dependent on ubiquitinated H2A Lys-119/Lys-120...
  13. Marashi F, Helms S, Shiels A, Silverstein S, Greenspan D, Stein G, et al. Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences. Biochem Cell Biol. 1986;64:277-89 pubmed
    We examined the structural and functional properties of a human H3 histone gene promoter. The complete nucleotide sequence of an H3 structural gene and 515 nucleotides of 5' and 100 nucleotides of 3' flanking sequences were determined...
  14. Tsukada Y, Fang J, Erdjument Bromage H, Warren M, Borchers C, Tempst P, et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006;439:811-6 pubmed
    ..protein, JHDM1 (JmjC domain-containing histone demethylase 1), that specifically demethylates histone H3 at lysine 36 (H3-K36)...
  15. Cook A, Gurard Levin Z, Vassias I, Almouzni G. A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain. Mol Cell. 2011;44:918-27 pubmed publisher
    ..that the histone chaperone nuclear autoantigenic sperm protein (NASP) protects a reservoir of soluble histones H3-H4...
  16. Ansari K, Mishra B, Mandal S. Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Biochim Biophys Acta. 2008;1779:66-73 pubmed
    Human encodes several histone H3-Lysine 4 (H3K4) specific methyl-transferases (HMTs) such as MLL1 (mixed lineage leukemia 1), MLL2, MLL3, hSet1 etc, that play critical roles in gene expression...
  17. Shen W, Xu C, Huang W, Zhang J, Carlson J, Tu X, et al. Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails. Biochemistry. 2007;46:2100-10 pubmed
    ..0 and 3.6 mM, respectively. In this study the dominant substrate was H3-AcK14 (KD approximately 1.2 mM). Mutagenesis analysis reveals several residues important for the binding specificity...
  18. Zheng Y, Fornelli L, Compton P, Sharma S, Canterbury J, Mullen C, et al. Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Mol Cell Proteomics. 2016;15:776-90 pubmed publisher
    ..e. methylation and acetylation) on full length histone H3 from human cell lines derived from multiple myeloma patients with overexpression of the histone methyltransferase ..
  19. Neumann H, Hancock S, Buning R, Routh A, Chapman L, Somers J, et al. A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell. 2009;36:153-63 pubmed publisher
    ..With these designer nucleosomes, we demonstrate that, in contrast to the prevailing dogma, acetylation of H3 K56 does not directly affect the compaction of chromatin and has modest effects on remodeling by SWI/SNF and RSC...
  20. Gessi M, Capper D, Sahm F, Huang K, von Deimling A, Tippelt S, et al. Evidence of H3 K27M mutations in posterior fossa ependymomas. Acta Neuropathol. 2016;132:635-7 pubmed publisher
  21. Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, et al. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev. 2007;21:3369-80 pubmed
    ..We show here that PRMT6 methylates histone H3 at R2 and histones H4/H2A at R3 in vitro...
  22. Li J, Chu M, Wang S, CHAN D, Qi S, Wu M, et al. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. J Biol Chem. 2012;287:10089-98 pubmed publisher
    ..Thus, our study has identified a novel H3K4me2-binding protein and revealed a role of NRDc in transcriptional regulation. ..
  23. Tachiwana H, Osakabe A, Shiga T, Miya Y, Kimura H, Kagawa W, et al. Structures of human nucleosomes containing major histone H3 variants. Acta Crystallogr D Biol Crystallogr. 2011;67:578-83 pubmed publisher
    ..In the nucleosome, two copies of each core histone, H2A, H2B, H3 and H4, form a histone octamer which wraps 146 base pairs of DNA around itself...
  24. Lin C, Li B, Swanson S, Zhang Y, Florens L, Washburn M, et al. Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell. 2008;32:696-706 pubmed publisher
    ..Collectively, these results suggest a function of HP1a in transcription facilitating H3K36 demethylation at transcribed and/or heterochromatin regions. ..
  25. Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H. Human tNASP promotes in vitro nucleosome assembly with histone H3.3. Biochemistry. 2015;54:1171-9 pubmed publisher
    ..respectively, have been found, and the shorter form, sNASP, reportedly promotes nucleosome assembly with the histone H3 isoforms, H3.1, H3.2, and H3.3...
  26. Groocock L, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, et al. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep. 2014;15:601-8 pubmed publisher
    ..Furthermore, RNF4 nucleosome-targeting is crucially required for the repair of TRF2-depleted dysfunctional telomeres by 53BP1-mediated non-homologous end joining...
  27. Hake S, Garcia B, Duncan E, Kauer M, Dellaire G, Shabanowitz J, et al. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem. 2006;281:559-68 pubmed
    ..Interest in non-allelic histone variants has been renewed, in part because of recent work on H3 (and other) histone variants. However, only in mammals do three non-centromeric H3 variants (H3.1, H3.2, and H3...
  28. Zippo A, De Robertis A, Serafini R, Oliviero S. PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat Cell Biol. 2007;9:932-44 pubmed
    ..PIM1 to the E boxes of the MYC-target genes FOSL1 (FRA-1) and ID2, and PIM1 phosphorylates serine 10 of histone H3 (H3S10) on the nucleosome at the MYC-binding sites, contributing to their transcriptional activation...
  29. Chang Q, Zhang Y, Beezhold K, Bhatia D, Zhao H, Chen J, et al. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol. 2009;50:323-33 pubmed publisher
    ..The JNK activation, global gene expression, and the status of histone H3 methylations were measured in 31 primary human hepatocellular carcinoma (HCC) samples paired with the adjacent non-..
  30. Tvardovskiy A, Wrzesinski K, Sidoli S, Fey S, Rogowska Wrzesinska A, Jensen O. Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns. Mol Cell Proteomics. 2015;14:3142-53 pubmed publisher
    ..Using top-down and middle-down protein analysis by mass spectrometry, we report histone H2B and H3 N-terminal tail clipping in human hepatocytes and demonstrate a relationship between clipping and co-existing PTMs ..
  31. Karagianni P, Amazit L, Qin J, Wong J. ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol. 2008;28:705-17 pubmed
    Methylation of histone H3 on lysine 9 is critical for diverse biological processes including transcriptional repression, heterochromatin formation, and X inactivation...
  32. Nishio H, Walsh M. CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Proc Natl Acad Sci U S A. 2004;101:11257-62 pubmed
    ..with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter...
  33. Elsässer S, Huang H, Lewis P, Chin J, Allis C, Patel D. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature. 2012;491:560-5 pubmed publisher
    ..DAXX is a metazoan histone chaperone specific to the evolutionarily conserved histone variant H3.3. Here we report the crystal structures of the DAXX histone-binding domain with a histone H3...
  34. Rothbart S, Krajewski K, Nady N, Tempel W, Xue S, Badeaux A, et al. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 2012;19:1155-60 pubmed publisher
    ..Here we show that UHRF1 association with methylated histone H3 Lys9 (H3K9) is required for DNA methylation maintenance...
  35. Wu L, Zee B, Wang Y, Garcia B, Dou Y. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Mol Cell. 2011;43:132-44 pubmed publisher
    ..H2B K34ub by MSL1/2 directly regulates H3 K4 and K79 methylation through trans-tail crosstalk both in vitro and in cells...
  36. Palacios A, Muñoz I, Pantoja Uceda D, Marcaida M, Torres D, Martín García J, et al. Molecular basis of histone H3K4me3 recognition by ING4. J Biol Chem. 2008;283:15956-64 pubmed publisher
    ..Our results illustrate the versatility of PHD fingers as readers of the histone code. ..
  37. Wang L, Charroux B, Kerridge S, Tsai C. Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep. 2008;9:555-62 pubmed publisher
    ..and that both the ELM2 and SANT domains orchestrate molecular events that lead to a stable methylation of histone H3-lysine 9...
  38. Kobza K, Sarath G, Zempleni J. Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3. BMB Rep. 2008;41:310-5 pubmed
    ..Incubation of recombinant BirA ligase with H3-based synthetic peptides showed that lysines 4, 9, 18, and 23 in histone H3 are the targets for the biotinylation by ..
  39. Hammond S, Byrum S, Namjoshi S, Graves H, Dennehey B, Tackett A, et al. Mitotic phosphorylation of histone H3 threonine 80. Cell Cycle. 2014;13:440-52 pubmed publisher
    ..Among the proteins that are phosphorylated during mitosis is histone H3, which is heavily phosphorylated on its N-terminal tail...
  40. Rovnak J, Brewster C, Quackenbush S. Retroviral cyclin enhances cyclin-dependent kinase-8 activity. J Virol. 2012;86:5742-51 pubmed publisher
    ..activity of immune affinity-purified CDK8 in vitro for RNA polymerase II carboxy-terminal domain (CTD) and histone H3 substrates. PP2A also enhances CDK8 kinase activity in vitro for the CTD but not for histone H3...
  41. Ngollo M, Lebert A, Daures M, Judes G, Rifai K, Dubois L, et al. Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. BMC Cancer. 2017;17:261 pubmed publisher
    ..Our findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. The results reported here provide new molecular insights into the pathogenesis of prostate cancer. ..
  42. Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Kehlbach R, Rodemann H. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. Radiother Oncol. 2011;99:317-22 pubmed publisher
    ..of nuclear EGFR was analyzed after siRNA mediated depletion of EGFR with respect to activation of ATM, histone H3 acetylation, residual DNA-damage and cell survival after irradiation...
  43. Wang F, Ulyanova N, van der Waal M, Patnaik D, Lens S, Higgins J. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol. 2011;21:1061-9 pubmed publisher
    Haspin phosphorylates histone H3 at Thr3 (H3T3ph) during mitosis [1, 2], providing a chromatin binding site for the chromosomal passenger complex (CPC) at centromeres to regulate chromosome segregation [3-5]...
  44. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of ?-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19:17-30 pubmed publisher
    ..Hence, tumor-derived IDH1 and IDH2 mutations reduce ?-KG and accumulate an ?-KG antagonist, 2-HG, leading to genome-wide histone and DNA methylation alterations. ..
  45. Shankaranarayanan P, Chaitidis P, Kuhn H, Nigam S. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem. 2001;276:42753-60 pubmed
    ..After 9-11 h, when histones become acetylated, STAT6 binding sites may be demasked so that the phosphorylated and acetylated transcription factor can bind to activate gene transcription. ..
  46. Garcia B, Barber C, Hake S, Ptak C, Turner F, Busby S, et al. Modifications of human histone H3 variants during mitosis. Biochemistry. 2005;44:13202-13 pubmed
    Phosphorylation of histone H3 is a hallmark event in mitosis and is associated with chromosome condensation...
  47. Ohe Y, Iwai K. Human spleen histone H3. Isolation and amino acid sequence. J Biochem. 1981;90:1205-11 pubmed
    The amino acid sequence of human spleen histone H3 was investigated as a study in histone evolution, following previous investigations of human spleen histone H2B [Ohe, Y., Hayashi, H., & Iwai, K. (1979) J. Biochem...
  48. Khairalla A, Omer S, Mahdavi J, Aslam A, Dufailu O, Self T, et al. Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cell Microbiol. 2015;17:1008-20 pubmed publisher
    ..whereas in vitro clipping assays confirmed the ability of both proteins to proteolytically cleave the core histone H3. Finally, we show that App and MspA induce a dose-dependent increase in DC death via caspase-dependent apoptosis...
  49. Ghizzoni M, Wu J, Gao T, Haisma H, Dekker F, George Zheng Y. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012;47:337-44 pubmed publisher
    ..In addition, these HAT inhibitors effectively inhibited acetyltransferase activity of nuclear extracts on the histone H3 and H4 at micromolar concentrations.
  50. Kim J, Lane W, Reinberg D. Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A. 2002;99:1241-6 pubmed
    ..Human Elongator contains histone acetyltransferase activity with specificity to histone H3 and, to a much lesser extent, to histone H4...
  51. Yang C, van der Woerd M, Muthurajan U, Hansen J, Luger K. Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes. Nucleic Acids Res. 2011;39:4122-35 pubmed publisher
    ..We present ab initio envelope reconstructions of nucleosomes and their complexes with MeCP2 from SAXS data. SAXS studies also revealed unexpected sequence-dependent conformational variability in the nucleosomes themselves. ..
  52. Cereseto A, Manganaro L, Gutierrez M, Terreni M, Fittipaldi A, Lusic M, et al. Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J. 2005;24:3070-81 pubmed
    ..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification. ..
  53. Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, et al. Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1. Proc Natl Acad Sci U S A. 2012;109:12950-5 pubmed publisher
    ..crystal structure of the linked histone reader modules of UHRF1 in complex with the amino-terminal tail of histone H3. Our structural and biochemical data provide the basis for combinatorial readout of unmodified Arg-2 (H3-R2) and ..
  54. Díaz Jullien C, Pérez Estévéz A, Covelo G, Freire M. Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. Biochim Biophys Acta. 1996;1296:219-27 pubmed
    ..Pro T alpha and histones in solution) indicated that Pro T alpha has higher affinity for core histones (particularly H3 and H4) than for H1...
  55. Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle. 2009;8:1747-53 pubmed
    Histone H3 lysine 56 acetylation (H3K56Ac) has recently been identified and shown to be important for genomic stability in yeast. However, whether or not H3K56 acetylation occurs in mammals is not clear...
  56. Beck H, Nielsen E, Matthiesen R, Jensen L, Sehested M, Finn P, et al. Quantitative proteomic analysis of post-translational modifications of human histones. Mol Cell Proteomics. 2006;5:1314-25 pubmed
    ..A total of 32 acetylations, methylations, and ubiquitinations were located in the human histones H2A, H2B, H3, and H4, including seven novel modifications...
  57. Ruthenburg A, Li H, Milne T, Dewell S, McGinty R, Yuen M, et al. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 2011;145:692-706 pubmed publisher
    ..The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3)...
  58. Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy F, Walsh M. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J Biol Chem. 2004;279:54348-57 pubmed
    ..This methyltransferase activity is directed specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with co-activator-associated arginine methyltransferase 1 (CARM1) ..
  59. Bruston F, Delbarre E, Ostlund C, Worman H, Buendia B, Duband Goulet I. Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin. FEBS Lett. 2010;584:2999-3004 pubmed publisher
    ..We show that progerin tail has a reduced DNA/chromatin binding capacity and modified trimethylated H3K27 binding pattern, offering a molecular mechanism for heterochromatin alterations related to HGPS. ..
  60. Yamane K, Toumazou C, Tsukada Y, Erdjument Bromage H, Tempst P, Wong J, et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006;125:483-95 pubmed
    ..Thus, our work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation. ..
  61. Wu J, Cheung T, Grande C, Ferguson A, Zhu X, Theriault K, et al. Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase. Biochemistry. 2011;50:6488-97 pubmed publisher
    ..Taken together, these results demonstrated the functional importance of distinct domains in the SMYD family of proteins and further advanced our understanding of the catalytic mechanism of this family. ..
  62. Sengupta D, Byrum S, Avaritt N, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016;15:765-75 pubmed publisher
    ..Aggressive melanoma cell lines as well as metastatic melanoma were found to have elevated histone H3 Lys(27) trimethylation (H3K27me3) accompanied by overexpressed methyltransferase EZH2 that adds the specific ..
  63. Couture J, Collazo E, Hauk G, Trievel R. Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol. 2006;13:140-6 pubmed
    Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10...
  64. Eustermann S, Yang J, Law M, Amos R, Chapman L, Jelinska C, et al. Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat Struct Mol Biol. 2011;18:777-82 pubmed publisher
    ..wild-type ATRX protein targets pericentric and telomeric heterochromatin for deposition of the histone variant H3.3 by means of a largely unknown mechanism...
  65. Kristensen J, Nielsen A, Jørgensen L, Kristensen L, Helgstrand C, Juknaite L, et al. Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. FEBS Lett. 2011;585:1951-6 pubmed publisher
    ..This demonstrates that despite very similar active site topologies, selectivity between Jumonji family histone demethylases can be obtained even with small molecule ligands. ..
  66. Islam K, Zheng W, Yu H, Deng H, Luo M. Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling. ACS Chem Biol. 2011;6:679-84 pubmed publisher
    ..This approach is thus suitable for substrate characterization of G9a and expected to further serve as a starting point to evolve other PKMTs to utilize a similar set of cofactors. ..
  67. Braastad C, Hovhannisyan H, Van Wijnen A, Stein J, Stein G. Functional characterization of a human histone gene cluster duplication. Gene. 2004;342:35-40 pubmed
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