H19

Summary

Gene Symbol: H19
Description: H19, imprinted maternally expressed transcript (non-protein coding)
Alias: ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, PRO2605, WT2
Species: human
Products:     H19

Top Publications

  1. Zeschnigk M, Albrecht B, Buiting K, Kanber D, Eggermann T, Binder G, et al. IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia. Eur J Hum Genet. 2008;16:328-34 pubmed
    ..analysis, and in 1 patient with body asymmetry without any other features of SRS or Beckwith-Wiedemann syndrome (BWS)...
  2. Murphy S, Huang Z, Wen Y, Spillman M, Whitaker R, Simel L, et al. Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. Mol Cancer Res. 2006;4:283-92 pubmed
    ..The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic deregulation of the IGF2/H19 imprinted domain contributes to elevated IGF2 expression ..
  3. Luo M, Li Z, Wang W, Zeng Y, Liu Z, Qiu J. Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. FEBS J. 2013;280:1709-16 pubmed publisher
    Long noncoding RNAs have been shown to have important regulatory roles in cancer biology, and long noncoding RNA 19 (H19) is essential for human tumor growth...
  4. Ishihara K, Hatano N, Furuumi H, Kato R, Iwaki T, Miura K, et al. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting. Genome Res. 2000;10:664-71 pubmed
    ..methylated region (DMR) and endoderm-specific enhancers, located upstream and downstream of the mouse H19 gene, respectively, are known to be essential for the reciprocal imprinting of Igf2 and H19...
  5. Sparago A, Cerrato F, Vernucci M, Ferrero G, Silengo M, Riccio A. Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet. 2004;36:958-60 pubmed
    ..5. Here we show that inherited microdeletions in the H19 differentially methylated region (DMR) that abolish two CTCF target sites cause this disease...
  6. Zhang E, Han L, Yin D, Kong R, De W, Chen J. c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol. 2014;31:914 pubmed publisher
    ..The present study aimed to evaluate the potential role of lncRNA H19 in GC...
  7. Nativio R, Sparago A, Ito Y, Weksberg R, Riccio A, Murrell A. Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet. 2011;20:1363-74 pubmed publisher
    ..in reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders, Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS)...
  8. Cerrato F, Sparago A, Verde G, De Crescenzo A, Citro V, Cubellis M, et al. Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour. Hum Mol Genet. 2008;17:1427-35 pubmed publisher
    The parent of origin-dependent expression of the IGF2 and H19 genes is controlled by the imprinting centre 1 (IC1) consisting in a methylation-sensitive chromatin insulator...
  9. Beygo J, Citro V, Sparago A, De Crescenzo A, Cerrato F, Heitmann M, et al. The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites. Hum Mol Genet. 2013;22:544-57 pubmed publisher
    ..5, the imprinting centre 1 (IC1) controls the parent of origin-specific expression of the IGF2 and H19 genes...

More Information

Publications94

  1. Kallen A, Zhou X, Xu J, Qiao C, Ma J, Yan L, et al. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013;52:101-12 pubmed publisher
    Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer...
  2. Marques C, Carvalho F, Sousa M, Barros A. Genomic imprinting in disruptive spermatogenesis. Lancet. 2004;363:1700-2 pubmed
    ..However, methylation of the H19 gene did not change in any of 27 normozoospermic individuals (0%, 95% CI 0-13%), compared with methylation changes ..
  3. Debaun M, Niemitz E, Feinberg A. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet. 2003;72:156-60 pubmed
    ..that five of the six have specific epigenetic alterations associated with BWS-four at LIT1 and one at both LIT1 and H19. We discuss the implications of our finding that ART is associated with human overgrowth, similar to the large ..
  4. Lottin S, Adriaenssens E, Dupressoir T, Berteaux N, Montpellier C, Coll J, et al. Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. Carcinogenesis. 2002;23:1885-95 pubmed
    The maternally expressed H19 gene is transcribed as an untranslated RNA that serves as a riboregulator. We have previously reported that this transcript accumulates in epithelial cells in approximately 10% of breast cancers...
  5. Poole R, Leith D, Docherty L, Shmela M, Gicquel C, Splitt M, et al. Beckwith-Wiedemann syndrome caused by maternally inherited mutation of an OCT-binding motif in the IGF2/H19-imprinting control region, ICR1. Eur J Hum Genet. 2012;20:240-3 pubmed publisher
    ..phenotypes: an overgrowth disorder, the Beckwith-Wiedemann syndrome (maternal ICR1 hypermethylation in 10% of BWS cases) and a growth retardation disorder, the Silver-Russell syndrome (paternal ICR1 loss of methylation in 60% of ..
  6. Wu J, Qin Y, Li B, He W, Sun Z. Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma. Genomics. 2008;91:443-50 pubmed publisher
    ..carcinoma (HCC) tissues and 7 normal adult liver tissues were screened for heterozygous polymorphisms in IGF2, H19, and the differentially methylated region of H19 (H19DMR) using PCR-RFLP and PCR sequencing...
  7. Yu L, Chen M, Zhao D, Yi P, Lu L, Han J, et al. The H19 gene imprinting in normal pregnancy and pre-eclampsia. Placenta. 2009;30:443-7 pubmed publisher
    To characterize the H19 gene imprinting in the placental tissues of normal pregnancy and pre-eclampsia...
  8. Luo M, Li Z, Wang W, Zeng Y, Liu Z, Qiu J. Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett. 2013;333:213-21 pubmed publisher
    lncRNA H19 is essential for human tumor growth. However, little is known about whether H19 regulates bladder cancer metastasis...
  9. Byun H, Wong H, Birnstein E, Wolff E, Liang G, Yang A. Examination of IGF2 and H19 loss of imprinting in bladder cancer. Cancer Res. 2007;67:10753-8 pubmed
    ..We found 2/9 (22.2%) cases that displayed LOI of IGF2 and 2/16 (12.5%) that had LOI of H19, as determined by the evaluation of mRNA for biallelic expression...
  10. Brannan C, Dees E, Ingram R, Tilghman S. The product of the H19 gene may function as an RNA. Mol Cell Biol. 1990;10:28-36 pubmed
    The mouse H19 gene was identified as an abundant hepatic fetal-specific mRNA under the transcriptional control of a trans-acting locus termed raf...
  11. Adkins R, Somes G, Morrison J, Hill J, Watson E, Magann E, et al. Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. Pediatr Res. 2010;68:429-34 pubmed publisher
    ..We tested 18 single nucleotide polymorphisms (SNPs) in the IGF2, H19, and IGF2R genes for associations with birth weight variation in 342 mother-newborn pairs (birth weight 2.1-4...
  12. Demars J, Shmela M, Rossignol S, Okabe J, Netchine I, Azzi S, et al. Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders. Hum Mol Genet. 2010;19:803-14 pubmed publisher
    ..phenotypes: an overgrowth disorder, the Beckwith-Wiedemann syndrome (maternal ICR1 gain of methylation in 10% of BWS cases) and a growth retardation disorder, the Silver-Russell syndrome (paternal ICR1 loss of methylation in 60% of ..
  13. Gao W, Liu M, Yang Y, Yang H, Liao Q, Bai Y, et al. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1). RNA Biol. 2012;9:1002-10 pubmed publisher
    ..placentas exhibited decreased mRNA expression and hypermethylation in promoter region of the paternally imprinted H19 gene compared with normal placentas...
  14. Nativio R, Wendt K, Ito Y, Huddleston J, Uribe Lewis S, Woodfine K, et al. Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet. 2009;5:e1000739 pubmed publisher
    ..At the imprinted IGF2-H19 locus, CTCF plays an important role in organizing allele-specific higher-order chromatin conformation and functions ..
  15. Bruce S, Hannula Jouppi K, Peltonen J, Kere J, Lipsanen Nyman M. Clinically distinct epigenetic subgroups in Silver-Russell syndrome: the degree of H19 hypomethylation associates with phenotype severity and genital and skeletal anomalies. J Clin Endocrinol Metab. 2009;94:579-87 pubmed publisher
    The H19 imprinting control region (ICR), located on chromosome 11p15.5, has been reported hypomethylated in 20-65% of Silver-Russell syndrome (SRS) patients. We investigated the methylation status of 11p15...
  16. Matouk I, DeGroot N, Mezan S, Ayesh S, Abu lail R, Hochberg A, et al. The H19 non-coding RNA is essential for human tumor growth. PLoS ONE. 2007;2:e845 pubmed
    ..Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its ..
  17. Tabano S, Colapietro P, Cetin I, Grati F, Zanutto S, Mandò C, et al. Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction. Epigenetics. 2010;5:313-24 pubmed
    ..IGF2 and H19, belonging to the same cluster of imprinted genes and regulated by ICR1, DMR2 and H19 promoter elements, play a ..
  18. Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan Z, et al. H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT. Tumour Biol. 2014;35:9163-9 pubmed publisher
    The long noncoding RNA (lncRNA) H19 has been recently characterized as an oncogenic lncRNA in some tumors. However, the role of H19 in pancreatic ductal adenocarcinoma (PDAC) remains unclear...
  19. Li Z, Li Y, Li Y, Ren K, Li X, Han X, et al. Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    Long non-coding RNA (lncRNA) H19 in tumors played important roles in various biological processes. However, the biological role and molecular mechanism of H19 in breast cancer are unclear...
  20. Cui J, Mo J, Luo M, Yu Q, Zhou S, Li T, et al. c-Myc-activated long non-coding RNA H19 downregulates miR-107 and promotes cell cycle progression of non-small cell lung cancer. Int J Clin Exp Pathol. 2015;8:12400-9 pubmed
    To verify c-Myc can regulate the expression of lncRNA H19 directly in non-small cell lung cancer (NSCLC) and clarify the molecular mechanism on how lncRNA H19 promote the cell cycle progression of NSCLC...
  21. Bauderlique Le Roy H, Vennin C, Brocqueville G, Spruyt N, Adriaenssens E, Bourette R. Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19. Stem Cells Dev. 2015;24:1252-62 pubmed publisher
    ..Concomitant increased expression of the long noncoding RNA H19 was observed, which prompted us to investigate a putative role in stemness for this oncofetal gene...
  22. Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi C, et al. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget. 2016;7:38398-38407 pubmed publisher
    ..Here we report that the H19 long noncoding RNA (lncRNA) is significantly decreased in placentae from pregnancies with FGR...
  23. Wang Q, Cheng N, Li X, Pan H, Li C, Ren S, et al. Correlation of long non-coding RNA H19 expression with cisplatin-resistance and clinical outcome in lung adenocarcinoma. Oncotarget. 2017;8:2558-2567 pubmed publisher
    ..The present study aimed to investigate the correlation of long non-coding RNA (lncRNA) H19 with cisplatin-resistance and clinical outcome in lung adenocarcinoma...
  24. Turner C, Mackay D, Callaway J, Docherty L, Poole R, Bullman H, et al. Methylation analysis of 79 patients with growth restriction reveals novel patterns of methylation change at imprinted loci. Eur J Hum Genet. 2010;18:648-55 pubmed publisher
    ..status was analysed at target sequences within eleven imprinted loci (PLAGL1, IGF2R, PEG10, MEST1, GRB10, KCNQ1OT1, H19, IGF2P0, DLK1, PEG3, NESPAS)...
  25. Horike S, Ferreira J, Meguro Horike M, Choufani S, Smith A, Shuman C, et al. Screening of DNA methylation at the H19 promoter or the distal region of its ICR1 ensures efficient detection of chromosome 11p15 epimutations in Russell-Silver syndrome. Am J Med Genet A. 2009;149A:2415-23 pubmed publisher
    ..Of interest, in 3 of these 11 patients, the epigenetic alterations were limited to the H19 promoter and the distal region of its associated imprinting center, ICR1...
  26. Lv J, Ma L, Chen X, Huang X, Wang Q. Downregulation of LncRNAH19 and MiR-675 promotes migration and invasion of human hepatocellular carcinoma cells through AKT/GSK-3?/Cdc25A signaling pathway. J Huazhong Univ Sci Technolog Med Sci. 2014;34:363-369 pubmed publisher
    ..These findings suggested that inhibition of LncRNAH19 and miR-675 expression can promote migration and invasion of HCC cells via AKT/GSK-3?/Cdc25A signaling pathway. ..
  27. Matouk I, Raveh E, Abu lail R, Mezan S, Gilon M, Gershtain E, et al. Oncofetal H19 RNA promotes tumor metastasis. Biochim Biophys Acta. 2014;1843:1414-26 pubmed publisher
    The oncofetal H19 gene transcribes a long non-coding RNA(lncRNA) that is essential for tumor growth. Here we found that numerous established inducers of epithelial to mesenchymal transition(EMT) also induced H19/miR-675 expression...
  28. Luan W, Zhou Z, Ni X, Xia Y, Wang J, Yan Y, et al. Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis. J Cancer Res Clin Oncol. 2018;144:531-542 pubmed publisher
    lncRNA H19 has been considered as an oncogenic lncRNA in many human tumours. In the present study, we identify the role and molecular mechanism of lncRNA H19 in melanoma...
  29. Jurkiewicz D, Kugaudo M, Skorka A, Smigiel R, Smyk M, Ciara E, et al. A novel IGF2/H19 domain triplication in the 11p15.5 imprinting region causing either Beckwith-Wiedemann or Silver-Russell syndrome in a single family. Am J Med Genet A. 2017;173:72-78 pubmed publisher
    Defects of 11p15.5 imprinting result in two growth disorders with opposite phenotypes: Beckwith-Wiedemann syndrome (BWS) characterized by overgrowth and Silver-Russell syndrome (SRS) associated with growth retardation...
  30. Tessema M, Langer F, Bock O, Seltsam A, Metzig K, Hasemeier B, et al. Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. Int J Oncol. 2005;26:499-507 pubmed
    b>H19 and IGF-2 are two growth regulatory genes located on chromosome 11p15 implicated in tumorigenesis. Both genes are imprinted and regulated reciprocally under many circumstances...
  31. Petry C, Ong K, Barratt B, Wingate D, Cordell H, Ring S, et al. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet. 2005;6:22 pubmed
    ..We identified ten single nucleotide polymorphisms (SNPs) in H19, and we genotyped three of these SNPs in families from the contemporary ALSPAC UK birth cohort (1,696 children, 822 ..
  32. Chu M, Yuan W, Wu S, Wang Z, Mao L, Tian T, et al. Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls. Oncotarget. 2016;7:78631-78639 pubmed publisher
    b>H19 refers to a long non-coding RNA (lncRNA) that functions as an oncogenic molecule in different cancer cells...
  33. Hashad D, Elbanna A, Ibrahim A, Khedr G. Evaluation of the Role of Circulating Long Non-Coding RNA H19 as a Promising Novel Biomarker in Plasma of Patients with Gastric Cancer. J Clin Lab Anal. 2016;30:1100-1105 pubmed publisher
    b>H19 is one of the long non-coding RNAs (LncRNA) that is related to the progression of many diseases including cancers...
  34. Verhaegh G, Verkleij L, Vermeulen S, den Heijer M, Witjes J, Kiemeney L. Polymorphisms in the H19 gene and the risk of bladder cancer. Eur Urol. 2008;54:1118-26 pubmed publisher
    b>H19 is an imprinted gene coding for an oncofetal RNA that is down-regulated postnatally. Reactivation of the H19 gene has been observed in bladder tumors, and H19 expression has been associated with early recurrence of disease...
  35. Yang F, Bi J, Xue X, Zheng L, Zhi K, Hua J, et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J. 2012;279:3159-65 pubmed publisher
    Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA H19 is up-regulated in hypoxic stress and in some tumors...
  36. Wu Q, Yan W, Han R, Yang J, Yuan J, Ji X, et al. Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. Int J Environ Res Public Health. 2016;13: pubmed publisher
    The H19 is a kind of long noncoding RNA, which has been implicated in multiple biological functions...
  37. Wang J, Zhao H, Fan Z, Li G, Ma Q, Tao Z, et al. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization. Stroke. 2017;48:2211-2221 pubmed publisher
    Long noncoding RNA H19 is repressed after birth, but can be induced by hypoxia. We aim to investigate the impact on and underlying mechanism of H19 induction after ischemic stroke...
  38. Guo G, Kang Q, Chen Q, Chen Z, Wang J, Tan L, et al. High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Lett. 2014;588:1780-6 pubmed publisher
    Dysregulation of non-coding RNA H19 has been observed in various tumors. However, it remains unknown whether H19 is involved in Bcr-Abl-induced leukemia...
  39. Kanduri M, Kanduri C, Mariano P, Vostrov A, Quitschke W, Lobanenkov V, et al. Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol. 2002;22:3339-44 pubmed
    The 5' region of the H19 gene harbors a methylation-sensitive chromatin insulator within an imprinting control region (ICR)...
  40. Rotondo J, Selvatici R, Di Domenico M, Marci R, Vesce F, Tognon M, et al. Methylation loss at H19 imprinted gene correlates with methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples from infertile males. Epigenetics. 2013;8:990-7 pubmed publisher
    Aberrant methylation at the H19 paternal imprinted gene has been identified in different cohorts of infertile males. The causes of H19 methylation errors are poorly understood...
  41. Zhou X, Ye F, Yin C, Zhuang Y, Yue G, Zhang G. The Interaction Between MiR-141 and lncRNA-H19 in Regulating Cell Proliferation and Migration in Gastric Cancer. Cell Physiol Biochem. 2015;36:1440-52 pubmed
    ..miR-141) has been reported to play a role in the epithelial to mesenchymal transition (EMT) process and H19 has also been demonstrated to promote malignancy in various cancers...
  42. Liu L, Yang J, Zhu X, Li D, Lv Z, Zhang X. Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. FEBS J. 2016;283:2326-39 pubmed publisher
    The long noncoding RNA H19 is overexpressed in many cancers and acts as an oncogene. Here, we investigated the role of H19 in thyroid carcinogenesis and its relation to microRNA miR-17-5p and its target gene YES1...
  43. Marášek P, Dzijak R, Studenyak I, Fišerová J, Uličná L, Novák P, et al. Paxillin-dependent regulation of IGF2 and H19 gene cluster expression. J Cell Sci. 2015;128:3106-16 pubmed publisher
    ..Here, we introduce paxillin as a transcriptional regulator of IGF2 and H19 genes...
  44. Ying W, Jingli F, Wei S, Li W. Genomic imprinting status of IGF-II and H19 in placentas of fetal growth restriction patients. J Genet. 2010;89:213-6 pubmed
  45. Grbesa I, Marinkovic M, Ivkic M, Kruslin B, Novak Kujundzic R, Pegan B, et al. Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. J Mol Med (Berl). 2008;86:1057-66 pubmed publisher
    Imprinting analyses of IGF2 and H19, loss of heterozygosity (LOH) analyses of IGF2R and CTCF and Helicobacter pylori detection, were performed on 35 human laryngeal squamous cell carcinomas (LSCC)...
  46. Min H, Lee S, Woo J, Jung H, Park K, Jeong H, et al. Essential Role of DNA Methyltransferase 1-mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors. Clin Cancer Res. 2017;23:1299-1311 pubmed publisher
    ..b>Experimental Design: The methylation status of CCCTC-binding factor (CTCF)-binding sites in the IGF2/H19 imprinting control region (ICR) were determined by methylation-specific PCR and bisulfite sequencing...
  47. Ramani K, Mavila N, Ko K, Mato J, Lu S. Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes. J Biol Chem. 2016;291:24148-24159 pubmed
    ..Phb1 knock-out livers show induction of tumor growth-associated genes, H19 and insulin-like growth factor 2 (Igf2)...
  48. Wang W, Ye H, Wei P, Han B, He B, Chen Z, et al. LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner. J Hematol Oncol. 2016;9:117 pubmed
    ..We identified that two lncRNAs, H19 and HULC, were differentially expressed among all the samples under the treatment of hypoxic or inflammatory ..
  49. Liang W, Fu W, Wong C, Wang Y, Wang W, Hu G, et al. The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget. 2015;6:22513-25 pubmed
    Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic gene in multiple cancer types and elevated expression of H19 was tightly linked to tumorigenesis and cancer progression...
  50. Men Y, Fan Y, Shen Y, Lu L, Kallen A. The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis. Endocrinology. 2017;158:402-409 pubmed publisher
    ..that StAR is a novel target of the microRNA let-7, which itself is regulated by the long noncoding RNA (lncRNA) H19. Using human and murine cell lines, we show that overexpression of H19 stimulates StAR expression by antagonizing ..
  51. Hur S, Freschi A, Ideraabdullah F, Thorvaldsen J, Luense L, Weller A, et al. Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes. Proc Natl Acad Sci U S A. 2016;113:10938-43 pubmed publisher
    ..locus, the misregulation of which is associated with the human imprinting disorders Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS)...
  52. Gao W, Li D, Xiao Z, Liao Q, Yang H, Li Y, et al. Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas. Hypertens Res. 2011;34:655-61 pubmed publisher
    ..In the present study, we investigated global DNA methylation as well as DNA methylation of the paternally imprinted H19 gene in preeclamptic placentas...
  53. Zou T, Jaladanki S, Liu L, Xiao L, Chung H, Wang J, et al. H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR. Mol Cell Biol. 2016;36:1332-41 pubmed publisher
    ..The H19 long noncoding RNA (lncRNA) regulates the expression of different genes and has been implicated in human genetic ..
  54. Ng A, Tang J, Goh C, Hui K. Regulation of the H19 imprinting gene expression in human nasopharyngeal carcinoma by methylation. Int J Cancer. 2003;104:179-87 pubmed
    ..to be specifically upregulated in the undifferentiated human NPC cell line CNE-2 is the human imprinting gene H19. Interestingly, H19 is not expressed in the well-differentiated human HK1 NPC cells...
  55. Chen T, Yang P, He Z. Long non-coding RNA H19 can predict a poor prognosis and lymph node metastasis: a meta-analysis in human cancer. Minerva Med. 2016;107:251-8 pubmed
    A long non-coding RNA (lncRNA) H19 has been reported to be aberrantly regulated in a wide range of cancers. This meta-analysis was performed to explore the potential value of H19 as a biomarker for cancer prognosis...
  56. Li M, Chen H, Zhao Y, Gao S, Cheng C. H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma. DNA Cell Biol. 2016;35:235-40 pubmed publisher
    ..b>H19 has been reported to play a potential role in osteosarcoma progression...
  57. Coutinho Camillo C, Brentani M, Butugan O, Torloni H, Nagai M. Relaxation of imprinting of IGFII gene in juvenile nasopharyngeal angiofibromas. Diagn Mol Pathol. 2003;12:57-62 pubmed
    IGFII and H19 genes are expressed only from one allele due to genomic imprinting, biallelic expression (loss of imprinting) being associated with the tumorigenic process of different types of tumors...
  58. He T, Xu D, Sui T, Zhu J, Wei Z, Wang Y. Association between H19 polymorphisms and osteosarcoma risk. Eur Rev Med Pharmacol Sci. 2017;21:3775-3780 pubmed
    The long non-coding RNA (lncRNA) H19, a maternally expressed imprinted gene, has involvement in cancer susceptibility and disease progression...
  59. Chen B, Yu M, Chang Q, Lu Y, Thakur C, Ma D, et al. Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin. Oncotarget. 2013;4:1427-37 pubmed
    ..total histone H3 lysine 9 trimethylation (H3K9me3), a significant reduction of H3K9me3 in the promoter region of H19, the paternally imprinted but maternally expressed gene transcribing a large intergenic non-coding RNA (lincRNA), ..
  60. Steck E, Boeuf S, Gabler J, Werth N, Schnatzer P, Diederichs S, et al. Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. J Mol Med (Berl). 2012;90:1185-95 pubmed publisher
    ..Among newly identified candidate molecules, H19, IGF2, and ITM2A were significantly elevated in OA compared to normal cartilage...
  61. Li B, Li J, Xiao X, Ma Y, Wang J, Liang X, et al. Altered DNA methylation patterns of the H19 differentially methylated region and the DAZL gene promoter are associated with defective human sperm. PLoS ONE. 2013;8:e71215 pubmed publisher
    ..Bisulfate-specific PCR was used to analyze DNA methylation of the H19-DMR and the DAZL promoter in these subjects...
  62. Lv J, Yu Y, Li S, Luo L, Wang Q. Aflatoxin B1 promotes cell growth and invasion in hepatocellular carcinoma HepG2 cells through H19 and E2F1. Asian Pac J Cancer Prev. 2014;15:2565-70 pubmed
    b>H19 is an imprinted oncofetal gene, and loss of imprinting at the H19 locus results in over-expression of H19 in cancers. Aflatoxin B1(AFB1) is regarded as one of the most dangerous carcinogens...
  63. Li S, Yu Z, Chen S, Li F, Lei C, Chen X, et al. The YAP1 oncogene contributes to bladder cancer cell proliferation and migration by regulating the H19 long noncoding RNA. Urol Oncol. 2015;33:427.e1-10 pubmed publisher
    Yes-associated protein 1 (YAP1) and long noncoding RNA H19 act as potent oncogenes in many human cancers, but little is known about their roles in bladder cancer or their relationship with each other...
  64. Izzi B, Francois I, Labarque V, Thys C, Wittevrongel C, Devriendt K, et al. Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction. PLoS ONE. 2012;7:e38579 pubmed publisher
    ..Since some AHO features are present in other imprinting disorders, the methylation of IGF2, H19, SNURF and GRB10 was quantified. Surprisingly, significant IGF2 hypermethylation (20 ± 10 vs. 14 ± 7%; p<0...
  65. Bi H, Yang X, Yuan J, Yang F, Xu D, Guo Y, et al. H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex. Biochim Biophys Acta. 2013;1830:4899-906 pubmed publisher
    b>H19 was one of the earliest identified, and is the most studied, long noncoding RNAs. It is presumed that H19 is essential for regulating development and disease conditions, and it is associated with carcinogenesis for many types...
  66. Pidsley R, Dempster E, Troakes C, Al Sarraj S, Mill J. Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics. 2012;7:155-63 pubmed publisher
    ..of IGF2 is regulated by DNA methylation at three differentially methylated regions (DMRs) spanning the IGF2/H19 domain on human 11p15.5...
  67. Couch F, Wang X, McWilliams R, Bamlet W, de Andrade M, Petersen G. Association of breast cancer susceptibility variants with risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:3044-8 pubmed publisher
    ..Ten SNPs from FGFR2, TOX3, MAP3K1, H19, LSP1, chromosome 8q24, CASP8, and LUM were investigated for associations with pancreatic cancer risk following ..
  68. Pick M, Stelzer Y, Bar Nur O, Mayshar Y, Eden A, Benvenisty N. Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells. Stem Cells. 2009;27:2686-90 pubmed publisher
    ..However, we found biallelic expression of the H19 gene in one iPS cell line and biallelic expression of the KCNQ10T1 gene in another iPS cell line...
  69. Li S, Hua Y, Jin J, Wang H, Du M, Zhu L, et al. Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population. Oncotarget. 2016;7:25470-7 pubmed publisher
    The long non-coding RNA (lncRNA) gene, H19, has been involving in multiple biological functions, which also plays a vital role in colorectal cancer carcinogenesis...
  70. Gao T, He B, Pan Y, Xu Y, Li R, Deng Q, et al. Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. Mol Carcinog. 2015;54:359-67 pubmed publisher
    ..91H, a novel long noncoding antisense transcripts located on the position of the H19/IGF2 locus has been suggested to play a potential tumor-suppressor role in tumor development...
  71. Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, et al. lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J. 2014;281:3766-75 pubmed publisher
    ..In this study, we found that long non-coding RNA H19 (H19) and H19-derived microRNA-675 (miR-675) were significantly downregulated in the metastatic prostate cancer ..
  72. Koukoura O, Sifakis S, Zaravinos A, Apostolidou S, Jones A, Hajiioannou J, et al. Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction. Placenta. 2011;32:51-7 pubmed publisher
    ..The H19 gene is abundantly expressed by the human placenta and is implicated in the pathogenesis of congenital growth ..
  73. Liu F, Pan H, Xia G, Qiu C, Zhu Z. Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis. Oncotarget. 2016;7:83177-83186 pubmed publisher
    Many studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development...
  74. Lee H, Choi N, Lee S, Ko K, Hwang T, Han D, et al. Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells. Epigenetics. 2016;11:177-83 pubmed publisher
    ..The androgenetic patterns of H19, Snrpn, and Mest were maintained even after differentiation of gPS cells into NSCs (gPS-NSCs), whereas the fully ..
  75. Giovarelli M, Bucci G, Ramos A, Bordo D, Wilusz C, Chen C, et al. H19 long noncoding RNA controls the mRNA decay promoting function of KSRP. Proc Natl Acad Sci U S A. 2014;111:E5023-8 pubmed publisher
    ..unanticipated interaction of the RNA binding protein K homology-type splicing regulatory protein (KSRP) with the H19 lncRNA (H19)...
  76. Zhang Z, Weaver D, Olsen D, deKay J, Peng Z, Ashikaga T, et al. Long non-coding RNA chromogenic in situ hybridisation signal pattern correlation with breast tumour pathology. J Clin Pathol. 2016;69:76-81 pubmed publisher
    ..Staining was graded by modified Allred scoring. HOTAIR, H19 and KCNQ1OT1 had significantly higher expression levels in IBC and DCIS than NA (p<0...
  77. Gucev Z, Saranac L, Jancevska A, Tasic V. The degree of H19 hypomethylation in children with Silver-Russel syndrome (SRS) is not associated with the severity of phenotype and the clinical severity score (CSS). Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2013;34:79-83 pubmed
    Hypomethylation of the imprinting control region 1 (ICR 1) at the IGF2/H19 locus on 11p15 is linked to Silver-Russel syndrome (SRS)...
  78. Hewage A, Jayanthiny P, Tennekoon K, Kumarasiri J, De S Wijesundere A, Karunanayake E. H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight. Endocrine. 2015;48:1010-2 pubmed publisher
  79. Sun H, Wang G, Peng Y, Zeng Y, Zhu Q, Li T, et al. H19 lncRNA mediates 17β-estradiol-induced cell proliferation in MCF-7 breast cancer cells. Oncol Rep. 2015;33:3045-52 pubmed publisher
    ..In the present study, we investigated the estrogen inducibility and functional significance of H19 lncRNA in breast cancer cells and tumor tissues...
  80. Wang S, Wu X, Zhang M, Weng M, Zhou D, Quan Z. Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2. Tumour Biol. 2016;37:9721-30 pubmed publisher
    Gallbladder cancer (GBC) is a highly malignant cancer with poor prognosis. Although long noncoding RNA (lncRNA) H19 has been reported to play vital role in many human cancers, whether it is involved in GBC proliferation is still unknown...
  81. Robbins K, Chen Z, WELLS K, Rivera R. Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine. J Biomed Sci. 2012;19:95 pubmed publisher
    Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and abdominal wall defects...
  82. Nelissen E, Dumoulin J, Daunay A, Evers J, Tost J, van Montfoort A. Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions. Hum Reprod. 2013;28:1117-26 pubmed publisher
    ..have an effect on the epigenetic regulation of the human placenta? We found a reduced DNA methylation level at the H19 and MEST differentially methylated regions (DMRs), and an increased RNA expression of H19 in placentas from ..
  83. Bouwland Both M, van Mil N, Stolk L, Eilers P, Verbiest M, Heijmans B, et al. DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study. PLoS ONE. 2013;8:e81731 pubmed publisher
    ..cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR...
  84. Joubel A, Curgy J, Pelczar H, Begue A, Lagrou C, Stehelin D, et al. The 5' part of the human H19 RNA contains cis-acting elements hampering its translatability. Cell Mol Biol (Noisy-le-grand). 1996;42:1159-72 pubmed
    b>H19 is an imprinted gene developmentally regulated in man and mouse and implicated in various neoplasms...
  85. Gao Z, Suppola S, Liu J, Heikkila P, Janne J, Voutilainen R. Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors. J Clin Endocrinol Metab. 2002;87:1170-6 pubmed
    Low H19 and abundant IGF-II expression may have a role in the development of adrenocortical carcinomas...