Gene Symbol: GTT1
Description: StAR related lipid transfer domain containing 7
Alias: GTT1, stAR-related lipid transfer protein 7, mitochondrial, START domain containing 7, START domain-containing protein 7, StAR-related lipid transfer (START) domain containing 7, gestational trophoblastic tumor protein 1
Species: human
Products:     GTT1

Top Publications

  1. Durand S, Angeletti S, Genti Raimondi S. GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization. Placenta. 2004;25:37-44 pubmed
    We report the cDNA cloning and characterization of GTT1/StarD7, a novel gestational trophoblastic tumour gene, initially identified by its up-regulated expression in the choriocarcinoma JEG-3 cell line with respect to their nonmalignant ..
  2. Rena V, Angeletti S, Panzetta Dutari G, Genti Raimondi S. Activation of beta-catenin signalling increases StarD7 gene expression in JEG-3 cells. Placenta. 2009;30:876-83 pubmed publisher
    ..Collectively, these studies show that beta-catenin and TCF4 activate the human StarD7 gene interacting with its promoter region through Wnt/beta-catenin signalling. ..
  3. Horibata Y, Sugimoto H. StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria. J Biol Chem. 2010;285:7358-65 pubmed publisher
    ..These results suggest that StarD7 facilitates the delivery of PC to mitochondria in non-vesicular system. ..
  4. Rena V, Flores Mart n J, Angeletti S, Panzetta Dutari G, Genti Raimondi S. StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling. Mol Endocrinol. 2011;25:1364-75 pubmed publisher
    ..The SF-1 and ?-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development...
  5. Angeletti S, Sanchez J, Chamley L, Genti Raimondi S, Perillo M. StarD7 behaves as a fusogenic protein in model and cell membrane bilayers. Biochim Biophys Acta. 2012;1818:425-33 pubmed publisher
    ..Moreover, this process was favored by phosphatidylethanolamine which is known to stabilize non-lamellar phases considered as intermediary in the fusion process. Altogether these findings allow postulate StarD7 as a fusogenic protein...
  6. Gao Y, Fang L, Wang X, Lan R, Wang M, Du G, et al. Antioxidant Activity Evaluation of Dietary Flavonoid Hyperoside Using Saccharomyces Cerevisiae as a Model. Molecules. 2019;24: pubmed publisher
    ..and lowered intracellular reactive oxygen species (ROS) levels in the wild-type strain (WT) and mutants gtt1 and gtt2∆...
  7. Flores Martín J, Reyna L, Cruz Del Puerto M, Rojas M, Panzetta Dutari G, Genti Raimondi S. Hexosamine pathway regulates StarD7 expression in JEG-3 cells. Mol Biol Rep. 2018;45:2593-2600 pubmed publisher
    ..This is the first study reporting the effects of glucose on StarD7 in trophoblast cells. These data highlight the importance to explore the role of StarD7 in placenta disorders related to nutrient availability. ..
  8. Hill R, Ringel A, Knuepfer E, Moon R, Blackman M, van Ooij C. Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites. J Biol Chem. 2016;291:24280-24292 pubmed
    ..These findings provide insight into a novel mechanism of regulation of phospholipid transfer in vivo and may have important implications for the interaction of the malaria parasite with its host cell. ..
  9. Bockelmann S, Mina J, Korneev S, Hassan D, Müller D, Hilderink A, et al. A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. J Lipid Res. 2018;59:515-530 pubmed publisher

More Information


  1. Yang L, Lewkowich I, Apsley K, Fritz J, Wills Karp M, Weaver T. Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin. J Immunol. 2015;194:5635-43 pubmed publisher
    ..Overall, these data suggest that Stard7 is an important component of a novel protective pathway in tissues exposed to the extracellular environment. ..
  2. Saita S, Tatsuta T, Lampe P, König T, Ohba Y, Langer T. PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. EMBO J. 2018;37: pubmed publisher
    ..Thus, PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol. ..
  3. Lin S, Ikegami M, Moon C, Naren A, Shannon J. Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells. J Biol Chem. 2015;290:18559-74 pubmed publisher
    ..LPCAT1 also interacted with one isoform of StarD7 but showed no interaction with StarD2/PC transfer protein. ..
  4. Calmes B, Morel Rouhier M, Bataillé Simoneau N, Gelhaye E, Guillemette T, Simoneau P. Characterization of glutathione transferases involved in the pathogenicity of Alternaria brassicicola. BMC Microbiol. 2015;15:123 pubmed publisher
    ..Analysis of their catalytic properties revealed that two GSTs, belonging to the GSTFuA and GTT1 classes, exhibited GSH transferase activity with isothiocyanates (ITC) and peroxidase activity with cumene ..
  5. Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen R, Tang W, et al. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Circ Cardiovasc Genet. 2013;6:82-8 pubmed publisher
    ..16; P=0.004). We identified 2 loci, near NCOA2 and in the TNNT2 gene, at which variation was significantly associated with hs-cTnT levels. Further use of the new assay should enable replication of these results. ..
  6. Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, et al. StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria. J Biol Chem. 2016;291:24880-24891 pubmed
    ..These findings indicate that StarD7 plays important roles in maintaining the proper composition of mitochondrial phospholipids as well as mitochondrial function and morphogenesis. ..
  7. Flores Martín J, Rena V, Marquez S, Panzetta Dutari G, Genti Raimondi S. StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells. PLoS ONE. 2012;7:e44152 pubmed publisher
    ..Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette sub-family G member 2) was one of the most abundantly downregulated mRNAs...
  8. Bao L, Zhang Y, Wang J, Wang H, Dong N, Su X, et al. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer. Cell Biol Toxicol. 2016;32:419-35 pubmed publisher
    ..Our results suggested that a number of altered chromosome 2 genes have the subtype or stage specificities of lung cancer and may be considered as diagnostic and prognostic biomarkers. ..
  9. Flores Martín J, Reyna L, Ridano M, Panzetta Dutari G, Genti Raimondi S. Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production. Free Radic Biol Med. 2016;99:286-295 pubmed publisher
    ..Taken together, these results indicate that StarD7 contributes to modulate cellular redox homeostasis. ..
  10. Horibata Y, Ando H, Satou M, Shimizu H, Mitsuhashi S, Shimizu Y, et al. Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer. Sci Rep. 2017;7:8793 pubmed publisher
    ..These results suggest that StarD7 is anchored onto the OMM through its N-terminal TM domain, and the C-terminal START domain may extend into the cytoplasm and shuttle PC between the ER and OMM at the ER-mitochondria contact sites. ..
  11. Collinson E, Wheeler G, Garrido E, Avery A, Avery S, Grant C. The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem. 2002;277:16712-7 pubmed
    ..conjugation and removal from the cell because it is absent in strains lacking glutathione-S-transferases (GTT1, GTT2) or the GS-X pump (YCF1)...