GTF2H2

Summary

Gene Symbol: GTF2H2
Description: general transcription factor IIH subunit 2
Alias: BTF2, BTF2P44, T-BTF2P44, TFIIH, p44, general transcription factor IIH subunit 2, BTF2 p44, TFIIH basal transcription factor complex p44 subunit, basic transcription factor 2 44 kDa subunit, general transcription factor IIH polypeptide 2, general transcription factor IIH, polypeptide 2, 44kD subunit, general transcription factor IIH, polypeptide 2, 44kDa
Species: human
Products:     GTF2H2

Top Publications

  1. Giglia Mari G, Coin F, Ranish J, Hoogstraten D, Theil A, Wijgers N, et al. A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Nat Genet. 2004;36:714-9 pubmed
    ..TTD) results from mutations in the XPD and XPB subunits of the DNA repair and transcription factor TFIIH. In a third form of DNA repair-deficient TTD, called group A, none of the nine subunits encoding TFIIH carried ..
  2. Coin F, Marinoni J, Rodolfo C, Fribourg S, Pedrini A, Egly J. Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. Nat Genet. 1998;20:184-8 pubmed
    ..of the evolutionarily conserved helicase XPD, which is one of the subunits of the transcription/repair factor TFIIH (refs 1,2)...
  3. Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, et al. Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder. Nat Genet. 2000;26:307-13 pubmed
    ..most often results from mutations in the genes XPB or XPD, encoding helicases of the transcription/repair factor TFIIH. The genetic defect in a third group, TTD-A, is unknown, but is also caused by dysfunctioning TFIIH...
  4. Dubaele S, Proietti de Santis L, Bienstock R, Keriel A, Stefanini M, Van Houten B, et al. Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients. Mol Cell. 2003;11:1635-46 pubmed
    ..We also show that TFIIH from TTD patients, but not from XP patients, exhibits a significant in vitro basal transcription defect in ..
  5. Lu H, Yu D, Hansen A, Ganguly S, Liu R, Heckert A, et al. Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II. Nature. 2018;558:318-323 pubmed publisher
    ..T1 droplets, and this process is enhanced upon pre-phosphorylation by CDK7 of transcription initiation factor TFIIH1-3...
  6. Srivastava A, Badjatia N, Lee J, Hao B, GUNZL A. An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma brucei. Nucleic Acids Res. 2017;: pubmed publisher
    ..form the PIC are extremely divergent orthologues of the small nuclear RNA-activating complex, TBP, TFIIA, TFIIB, TFIIH, TFIIE and Mediator...
  7. Li W, Liu W, Kakoki A, Wang R, Adebali O, Jiang Y, et al. Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells. J Biol Chem. 2019;294:5914-5922 pubmed publisher
    ..up-regulated during differentiation, but not those of replication protein A (RPA) and transcription factor IIH (TFIIH)...
  8. Gao W, Xiao R, Peng B, Xu H, Shen H, Huang M, et al. Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A. 2015;112:E3327-36 pubmed publisher
    ..R469me1 was shown to mediate the interaction between HSP70 and TFIIH, which involves in RNA polymerase II phosphorylation and thus transcriptional initiation...
  9. Lewis B, Burlingame A, Myers S. Human RNA Polymerase II Promoter Recruitment in Vitro Is Regulated by O-Linked N-Acetylglucosaminyltransferase (OGT). J Biol Chem. 2016;291:14056-61 pubmed publisher
    ..and 5 of the pol II C-terminal domain are O-GlcNAcylated, suggesting an overlap with the transcription factor IIH (TFIIH)-dependent serine 5 phosphorylation events during initiation and P-TEFb (positive transcriptional elongation ..

More Information

Publications149 found, 100 shown here

  1. Nozawa K, Schneider T, Cramer P. Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nature. 2017;545:248-251 pubmed publisher
    ..The hook is flexibly linked to Mediator by a conserved hinge and contacts the transcription initiation factor IIH (TFIIH) kinase that phosphorylates the carboxy (C)-terminal domain (CTD) of Pol II and was recently positioned on the PIC...
  2. Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, et al. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell. 2017;43:240-252.e5 pubmed publisher
    ..data further imply that dPWP1 acts synergistically with mTOR signaling to regulate the nucleolar localization of TFIIH, a known elongation factor of Pol I...
  3. Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, et al. Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nat Struct Mol Biol. 2016;23:580-9 pubmed publisher
    ..of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH. Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II...
  4. Liu X. In vitro chromatin templates to study nucleotide excision repair. DNA Repair (Amst). 2015;36:68-76 pubmed publisher
    ..been utilized to follow direct removal of DNA damage; (c) six purified human DNA repair factors (RPA, XPA, XPC, TFIIH, XPG, and XPF-ERCC1) that have been used to reconstitute excision repair in vitro...
  5. Sugasawa K. Molecular mechanisms of DNA damage recognition for mammalian nucleotide excision repair. DNA Repair (Amst). 2016;44:110-117 pubmed publisher
    ..Accumulating evidence suggests that XPA and the helicase activity of transcription factor IIH (TFIIH) cooperate to verify abnormalities in DNA chemistry...
  6. Yang G, Ibuki Y. Cigarette sidestream smoke delays nucleotide excision repair - inhibited accumulation of repair proteins at DNA lesions. Carcinogenesis. 2017;: pubmed publisher
    ..The recruitment of the repair molecules, TFIIH, XPA, and XPG to pyrimidine dimers was markedly inhibited by CSS...
  7. Bucio Mendez A, Cruz Becerra G, Valadez Graham V, Dinkova T, Zurita M. The Dmp8-Dmp18 bicistron messenger RNA enables unusual translation during cellular stress. J Cell Biochem. 2019;120:3887-3897 pubmed publisher
    ..encoded in a bicistronic mRNA next to Dmp8 (Dmp8-Dmp18 transcript), a structural component of transcription factor TFIIH. The organization of these two genes as a bicistron is conserved in all arthropods, however the length of the ..
  8. Plaschka C, Larivière L, Wenzeck L, Seizl M, Hemann M, Tegunov D, et al. Architecture of the RNA polymerase II-Mediator core initiation complex. Nature. 2015;518:376-80 pubmed publisher
    ..The Mediator 'arm' and 'hook' domains contribute to a 'cradle' that may position the CTD and TFIIH kinase to stimulate Pol II phosphorylation.
  9. Balupillai A, Nagarajan R, Ramasamy K, Govindasamy K, Muthusamy G. Caffeic acid prevents UVB radiation induced photocarcinogenesis through regulation of PTEN signaling in human dermal fibroblasts and mouse skin. Toxicol Appl Pharmacol. 2018;352:87-96 pubmed publisher
    ..AKT kinases through activation of PTEN which subsequently promotes XPC dependant NER proteins such as XPC, XPE, TFIIH (p44) and ERCC1 in HDFa cells and mouse skin tissue...
  10. Fishburn J, Galburt E, Hahn S. Transcription Start Site Scanning and the Requirement for ATP during Transcription Initiation by RNA Polymerase II. J Biol Chem. 2016;291:13040-7 pubmed publisher
    ..that transcription in the purified yeast basal system is largely ATP-independent despite a requirement for the TFIIH DNA translocase subunit Ssl2...
  11. Tanaka A, Akimoto Y, Kobayashi S, Hisatake K, Hanaoka F, Ohkuma Y. Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription. Genes Cells. 2015;20:203-16 pubmed publisher
    ..Furthermore, TFIIEα-WH bound to the TFIIH XPB subunit at a third distinct region...
  12. Tomko E, Galburt E. Single-molecule approach for studying RNAP II transcription initiation using magnetic tweezers. Methods. 2019;: pubmed publisher
    ..complex (PIC) and often requires ATP hydrolysis by the Ssl2/XPB subunit of the general transcription factor TFIIH. Our mechanistic view of this process in Eukaryotes has recently been improved through a combination of structural ..
  13. Hantsche M, Cramer P. Conserved RNA polymerase II initiation complex structure. Curr Opin Struct Biol. 2017;47:17-22 pubmed publisher
    ..The additional factors TFIID, TFIIH, and Mediator have been located on the periphery of the core initiation complex, providing the topology of the ..
  14. Posternak V, Ung M, Cheng C, Cole M. MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase. Mol Cancer Res. 2017;15:213-224 pubmed publisher
    ..carboxy-terminal domain, mediated in part through an interaction between the TIP60 acetyltransferase complex and TFIIH. MYC enhances mRNA cap methylation above and beyond transcriptional induction. Mol Cancer Res; 15(2); 213-24...
  15. Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, et al. Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases. Oral Oncol. 2017;73:56-64 pubmed publisher
    ..33 (SHANK2, MMP16, TERT), and 8q24.3 (BOP1); and, losses at 5q22.2 (APC), 6q25.3 (GTF2H2) and 5q13.2 (SMN1) were observed in these samples...
  16. Smolarz B, Michalska M, Samulak D, Wojcik L, Romanowicz H. Studies of Correlations Between Single Nucleotide Polymorphisms of DNA Repair Genes and Endometrial Cancer in Polish Women. Anticancer Res. 2018;38:5223-5229 pubmed publisher
    ..1 (XRCC1)-Arg399Gln (rs25487); XRCC2-Arg188His (rs3218536); XRCC3-Thr241Met (rs861539); ERCC excision repair 2, TFIIH core complex helicase subunit (ERCC2)-Lys751Gln (rs13181); and 8-oxoguanine DNA glycosylase (OGG1)-Ser326Cys (..
  17. Dienemann C, Schwalb B, Schilbach S, Cramer P. Promoter Distortion and Opening in the RNA Polymerase II Cleft. Mol Cell. 2019;73:97-106.e4 pubmed publisher
    ..promoters that we show can still initiate transcription after depletion of the transcription factor (TF) IIH (TFIIH) translocase Ssl2 (XPB in human) from the nucleus in vivo...
  18. Jun S, Hirata A, Kanai T, Santangelo T, Imanaka T, Murakami K. The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration. Nat Commun. 2014;5:5132 pubmed publisher
    ..to Pol II that correspond to the binding sites of Pol II-specific general transcription factors including TFIIF, TFIIH and Mediator...
  19. Petrenko N, Jin Y, Wong K, Struhl K. Mediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell. 2016;64:443-454 pubmed publisher
    ..with the enhancer, but not with the core promoter, and it dissociates from the enhancer upon depletion of the TFIIH kinase...
  20. Luo S, Horvitz H. The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage. Curr Biol. 2017;27:661-672 pubmed publisher
    ..I4 neurogenesis by inhibiting the CDK-7/CYH-1 (CDK7/cyclin H) kinase module of the transcription initiation factor TFIIH. Ectopic expression of HLH-2 and HLH-3 together promoted expression of neuronal features in non-neuronal cells...
  21. Deitsch E, Hibbard E, Petersen J. The UVS9 gene of Chlamydomonas encodes an XPG homolog with a new conserved domain. DNA Repair (Amst). 2016;37:33-42 pubmed publisher
    ..Despite this difference, amino acid sequence alignment of UVS9p with XPG homologs revealed a new conserved domain involved in TFIIH interaction.
  22. Zhu Q, Wani G, Arab H, El Mahdy M, Ray A, Wani A. Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites. DNA Repair (Amst). 2009;8:262-73 pubmed publisher
    ..CAF-1 p150 was found to associate with NER factors TFIIH, RPA p70 and PCNA in chromatin...
  23. Bao X, Johnson J, Rao H. Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway. J Biol Chem. 2015;290:8606-12 pubmed publisher
    ..by the proteasome, we further delineated the specific pathway involved in the degradation of Rad25, a subunit of TFIIH. We demonstrate that Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin ligase Ufd4...
  24. Hu J, Ye F, Cui M, Lee P, Wei C, Hao Y, et al. Protein Profiling of Bladder Urothelial Cell Carcinoma. PLoS ONE. 2016;11:e0161922 pubmed publisher
    ..Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.
  25. Cheng Y, He H, Yang C, Yan Z, Zeng G, Qian H. Effects of anionic surfactant on n-hexane removal in biofilters. Chemosphere. 2016;150:248-253 pubmed publisher
    ..of n-hexane increased from 600 to 850 mg m(-3), the removal efficiency (RE) decreased from 67% to 41% by BTF2 (with SDS) and from 52% to 42% by BTF1 (without SDS)...
  26. Okuda M, Nishimura Y. Extended string binding mode of the phosphorylated transactivation domain of tumor suppressor p53. J Am Chem Soc. 2014;136:14143-52 pubmed publisher
    ..reveal the recognition mechanism of the phosphorylated TAD2 bound to a pleckstrin homology (PH) domain from human TFIIH subunit p62 in an extended string-like conformation...
  27. Zhovmer A, Oksenych V, Coin F. Two sides of the same coin: TFIIH complexes in transcription and DNA repair. ScientificWorldJournal. 2010;10:633-43 pubmed publisher
    b>TFIIH is organized into a seven-subunit core associated with a three-subunit Cdk-activating kinase (CAK) module. TFIIH has roles in both transcription initiation and DNA repair...
  28. Tajedin L, Anwar M, Gupta D, Tuteja R. Comparative insight into nucleotide excision repair components of Plasmodium falciparum. DNA Repair (Amst). 2015;28:60-72 pubmed publisher
    ..The multi-protein transcription initiation factor TFIIH plays a critical role in NER and transcription and is highly conserved throughout evolution...
  29. Fishburn J, Tomko E, Galburt E, Hahn S. Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation. Proc Natl Acad Sci U S A. 2015;112:3961-6 pubmed publisher
    ..of the RNA polymerase II (Pol II) open complex (OC) requires DNA unwinding mediated by the transcription factor TFIIH helicase-related subunit XPB/Ssl2...
  30. Li C, Golebiowski F, Onishi Y, Samara N, Sugasawa K, Yang W. Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair. Mol Cell. 2015;59:1025-34 pubmed publisher
    Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER)...
  31. Lee J, Mitchell N, Zaytseva O, Chahal A, Mendis P, Cartier Michaud A, et al. Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models. Nat Commun. 2015;6:7404 pubmed publisher
    ..but not others, with similar C-terminal mutations in the XPB helicase subunit of transcription and NER factor TFIIH. Mechanisms driving overproliferation and, therefore, cancer associated with XPB mutations are currently unknown...
  32. Lye M, Visuvanathan S, Chong P, Yap Y, Lim C, Ban E. Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population. PLoS ONE. 2015;10:e0130530 pubmed publisher
    ..pigmentosum group D (XPD) gene encodes a DNA helicase, an important component in transcription factor IIH (TFIIH) complex...
  33. Poss Z, Ebmeier C, Taatjes D. The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol. 2013;48:575-608 pubmed publisher
    ..within the pre-initiation complex (PIC), which consists of Mediator, pol II, TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and is approximately 4.0 MDa in size...
  34. Devos M, Mommaerts E, Migeot V, van Bakel H, Hermand D. Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities. Mol Cell Biol. 2015;35:1480-90 pubmed publisher
    ..CAK) complex, and serine 5 within the polymerase II (Pol II) C-terminal domain (CTD) as transcription factor TFIIH-bound CAK. However, the physiological importance of integrating these processes is not understood...
  35. Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, et al. Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature. 2017;551:204-209 pubmed publisher
    ..7 Å and 5.8 Å, respectively. The structures reveal transcription factor IIH (TFIIH), and suggest how the core and kinase TFIIH modules function in the opening of promoter DNA and the ..
  36. Sun Z, Yang B, Ding C, Li Z, Wang L. Enhanced removal of gaseous 1,3-dichlorobenzene in biotrickling filters by rhamnolipid and Mg (II). J Hazard Mater. 2018;360:571-577 pubmed publisher
    ..and 1,3-dichlorobenzene removal was investigated in two identical lab-scale biotrickling filters (named BTF1 and BTF2)...
  37. Yang G, Komaki Y, Ibuki Y. Aldehyde-mediated protein degradation is responsible for the inhibition of nucleotide excision repair by cigarette sidestream smoke. Mutat Res. 2018;834:42-50 pubmed publisher
    ..DNA damage, pyrimidine(6-4)pyrimidone photoproducts (6-4PPs), where the recruitments of repair molecules, TFIIH and XPG, were slowed down...
  38. Ribeiro Silva C, Aydin O, Mesquita Ribeiro R, Slyskova J, Helfricht A, Marteijn J, et al. DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1. Nat Commun. 2018;9:4067 pubmed publisher
    ..BRM/SMARCA2 and BRG1/SMARCA4 promote the expression of p62/GTF2H1, a core subunit of the transcription factor IIH (TFIIH) complex...
  39. Kikuchi Y, Umemura H, Nishitani S, Iida S, Fukasawa R, Hayashi H, et al. Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries. Genes Cells. 2015;20:191-202 pubmed publisher
    ..assays showed that hMED17 interacted with Pol II and the general transcription factors TFIIB, TBP, TFIIE, and TFIIH. In addition, hMED17 bound to a DNA helicase subunit of TFIIH, XPB, which is essential for both transcription and ..
  40. Harrod A, Fulton J, Nguyen V, Periyasamy M, Ramos Garcia L, Lai C, et al. Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene. 2017;36:2286-2296 pubmed publisher
    ..Further, we show that the basal transcription factor TFIIH is constitutively recruited by ER-Y537S, resulting in ligand-independent phosphorylation of Serine 118 (Ser118) by ..
  41. Galande A, Perween N, Saijo M, Ghaskadbi S, Ghaskadbi S. Analysis of the conserved NER helicases (XPB and XPD) and UV-induced DNA damage in Hydra. Biochim Biophys Acta Gen Subj. 2018;1862:2031-2042 pubmed publisher
    ..Pigmentosum group B (XPB) and group D (XPD) are important helicases in NER and are also critical subunits of TFIIH complex...
  42. Horibata K, Kono S, Ishigami C, Zhang X, Aizawa M, Kako Y, et al. Constructive rescue of TFIIH instability by an alternative isoform of XPD derived from a mutated XPD allele in mild but not severe XP-D/CS. J Hum Genet. 2015;60:259-65 pubmed publisher
    ..L461V;V716_R730del] by authentic splicing. Additionally, p.[L461V;A717G] could partially rescue the loss of XPD function, resulting in the milder manifestations observed in XP1NE and XPCS118LV. ..
  43. Narita T, Narita K, Takedachi A, Saijo M, Tanaka K. Regulation of Transcription Elongation by the XPG-TFIIH Complex Is Implicated in Cockayne Syndrome. Mol Cell Biol. 2015;35:3178-88 pubmed publisher
    ..XPG interacted with transcription elongation factors in concert with TFIIH, suggesting that the XPG-TFIIH complex serves as a transcription elongation factor...
  44. Compe E, Egly J. Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond. Annu Rev Biochem. 2016;85:265-90 pubmed publisher
    Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these two processes...
  45. Cruz Becerra G, Valerio Cabrera S, Juárez M, Bucio Mendez A, Zurita M. TFIIH localization is highly dynamic during zygotic genome activation in Drosophila, and its depletion causes catastrophic mitosis. J Cell Sci. 2018;131: pubmed publisher
    ..Transcription factor II H (TFIIH) is fundamental for transcription initiation by RNA polymerase II (RNAPII)...
  46. Fan L, DuPrez K. XPB: An unconventional SF2 DNA helicase. Prog Biophys Mol Biol. 2015;117:174-181 pubmed publisher
    ..XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter during the ..
  47. Akimoto Y, Yamamoto S, Iida S, Hirose Y, Tanaka A, Hanaoka F, et al. Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE. Genes Cells. 2014;19:879-90 pubmed publisher
    ..binds to single-stranded DNA and various transcriptional activators, including the general transcription factor TFIIH. In this study, we further investigated PC4 from Homo sapiens and the nematode Caenorhabditis elegans (hPC4 and ..
  48. Traboulsi H, Davoli S, Catez P, Egly J, Compe E. Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy. PLoS Genet. 2014;10:e1004732 pubmed publisher
    ..the molecular mechanisms that govern transcription, we focused our attention on the general transcription factor TFIIH, which gives rise, once mutated, to Trichothiodystrophy (TTD), a rare autosomal premature-ageing disease causing ..
  49. Cyr N, de La Fuente C, Lecoq L, Guendel I, Chabot P, Kehn Hall K, et al. A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence. Proc Natl Acad Sci U S A. 2015;112:6021-6 pubmed publisher
    ..through interactions between the viral nonstructural protein NSs and the host general transcription factor TFIIH. Here, we identify an interaction between a ΩXaV motif in NSs and the p62 subunit of TFIIH...
  50. Clavijo R, Arora H, Gibbs E, Cohen S, Griswold A, Bakircioglu E, et al. Whole Exome Sequencing of a Consanguineous Turkish Family Identifies a Mutation in GTF2H3 in Brothers With Spermatogenic Failure. Urology. 2018;120:86-89 pubmed publisher
    ..A nonsynonymous variant in "general transcription factor TFIIH subunit 3" (GTF2H3) was identified in this consanguineous family...
  51. Humbert S, van Vuuren H, Lutz Y, Hoeijmakers J, Egly J, Moncollin V. p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. EMBO J. 1994;13:2393-8 pubmed
    The human BTF2 (TFIIH) transcription factor is a multisubunit protein involved in transcription initiation by RNA polymerase II (B) as well as in DNA repair...
  52. Kemp M. DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH). J Biol Chem. 2017;292:12424-12435 pubmed publisher
    ..Together, these results reveal a previously unknown role for transcription factor IIH in ATR kinase activation in non-replicating, non-cycling cells. ..
  53. Gourdin A, van Cuijk L, Tresini M, Luijsterburg M, Nigg A, Giglia Mari G, et al. Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair. DNA Repair (Amst). 2014;24:46-56 pubmed publisher
    ..Pre-incision factors like XPC and TFIIH accumulate rapidly at locally induced UV-damage and remain visible up to 4h...
  54. Wang L, Yang C, Cheng Y, Huang J, Yang H, Zeng G, et al. Enhanced removal of ethylbenzene from gas streams in biotrickling filters by Tween-20 and Zn(II). J Environ Sci (China). 2014;26:2500-7 pubmed publisher
    ..of Tween-20 and Zn(II) on ethylbenzene removal were evaluated using two biotrickling filters (BTFs), BTF1 and BTF2. Only BTF1 was fed with Tween-20 and Zn(II)...
  55. Lee B, Lee H, Cho H, Suh D, Kim K, No J, et al. Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance. Anticancer Res. 2015;35:3909-16 pubmed
    The expression patterns of the key DNA damage response-related proteins, ataxia-telangiectasia and tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (RAD3)-related (ATR) and ataxia-telangiectasia-mutated (ATM) proteins in ..
  56. Stettler K, Li X, Sandrock B, Braga Lagache S, Heller M, Dümbgen L, et al. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Dis Model Mech. 2015;8:81-91 pubmed publisher
    ..showed how different xpd mutations affected the formation or stability of different transcription factor IIH (TFIIH) subcomplexes...
  57. Han Y, Huang W, Liu J, Liu D, Cui Y, Huang R, et al. Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells. Theranostics. 2017;7:1914-1927 pubmed publisher
    ..As a result, TPL suppresses the binding of AR to promoter regions in AR target genes along with reduced TFIIH and RNA Pol II recruitment...
  58. Tajedin L, Tarique M, Tuteja R. Plasmodium falciparum XPD translocates in 5' to 3' direction, is expressed throughout the blood stages, and interacts with p44. Protoplasma. 2015;252:1487-504 pubmed publisher
    XPD helicase, a TFIIH subunit, is essential for several processes including transcription, NER, cell cycle regulation, and apoptosis in eukaryotes...
  59. Kuper J, Braun C, Elias A, Michels G, Sauer F, Schmitt D, et al. In TFIIH, XPD helicase is exclusively devoted to DNA repair. PLoS Biol. 2014;12:e1001954 pubmed publisher
    The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER)...
  60. Tu Y, Yang C, Cheng Y, Zeng G, Lu L, Wang L. Effect of saponins on n-hexane removal in biotrickling filters. Bioresour Technol. 2015;175:231-8 pubmed publisher
    ..8 to 120.0gm(-3)h(-1), the removal efficiency (RE) for BTF1 (with saponins) and BTF2 (without saponins) decreased from 91.3% to 83.3% and from 62.8% to 56.8%, respectively...
  61. Kim J, Saint André C, Lim H, Hwang C, Egly J, Cho Y. Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44. J Biol Chem. 2015;290:8321-30 pubmed publisher
    The Ssl1/p44 subunit is a core component of the yeast/mammalian general transcription factor TFIIH, which is involved in transcription and DNA repair. Ssl1/p44 binds to and stimulates the Rad3/XPD helicase activity of TFIIH...
  62. Alekseev S, Nagy Z, Sandoz J, Weiss A, Egly J, Le May N, et al. Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression. Mol Cell. 2017;65:504-514.e4 pubmed publisher
    ..Current models suggest that class II gene transcription requires ATP and the TFIIH XPB subunit to open a promoter...
  63. Theodorou L, Nicolaou P, Koutsou P, Georghiou A, Anastasiadou V, Tanteles G, et al. Genetic findings of Cypriot spinal muscular atrophy patients. Neurol Sci. 2015;36:1829-34 pubmed publisher
    ..The SMN1 gene is located within an inverted duplication on chromosome 5q13 with the genes SMN2, NAIP and GTF2H2. MLPA analysis of 13 Cypriot SMA patients revealed that, 12 patients carried a homozygous SMN1 gene deletion and ..
  64. Liu Z, Zhang P, He X, Liu S, Tang S, Zhang R, et al. New multiplex real-time PCR approach to detect gene mutations for spinal muscular atrophy. BMC Neurol. 2016;16:141 pubmed publisher
    ..motor neuron (SMN), apoptosis inhibitory protein (NAIP) and general transcription factor IIH, polypeptide 2 gene (GTF2H2) was established and confirmed by DNA sequencing and multiplex ligation-dependent probe amplification (MLPA)...
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    b>TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a protein kinase, a bi-directional DNA helicase and is essential for both transcription and nucleotide excision repair (NER)...
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    ..RNA polymerase II, the mediator complex, TFIID, TFIIH, and several other transcriptional activators and repressors were also affinity purified with viral DNA...
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    The Cdk7 subunit of TFIIH phosphorylates RNA polymerase II (Pol II) during initiation, and, while recent studies show that inhibition of human Cdk7 negatively influences transcription, the mechanisms involved are unclear...
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    ..To facilitate the purification, we have developed an effective scheme that allows human TFIIH and pol II to be isolated from HeLa-derived cell lines that conditionally express the FLAG-tagged p62 subunit of ..
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    Structures of complete 10-subunit yeast TFIIH and of a nested set of subcomplexes, containing 5, 6, and 7 subunits, have been determined by electron microscopy (EM) and 3D reconstruction...
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    ..Our results reveal a close functional interplay between Mediator and TFIIH in the early stages of PIC development...
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    In global genome repair (GGR), XPC detects damaged nucleotides and recruits TFIIH complex...
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    ..In GGR, XPC detects DNA lesions and recruits TFIIH via interaction with the pleckstrin homology (PH) domain of TFIIH subunit p62...
  76. Chakraborty A, Wakamiya M, Venkova Canova T, Pandita R, Aguilera Aguirre L, Sarker A, et al. Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. J Biol Chem. 2015;290:24636-48 pubmed publisher
    ..mouse tissue showed the association of NEIL2 with RNA polymerase II, along with Cockayne syndrome group B protein, TFIIH, and other BER proteins...
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    b>TFIIH is a 10-subunit RNA polymerase II basal transcription factor with a dual role in DNA repair. TFIIH contains three enzymatic functions and over 30 conserved subdomains and topological regions...
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    ..domain (TAD) of E2F1 is known to interact with the TATA-binding protein of TFIID and the p62 subunit of TFIIH. It is generally believed that DP1 facilitates E2F1 binding to target DNA and does not possess a TAD...
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    The removal of 2-butoxyethanol from gaseous emissions was studied using two biotrickling filters (BTF1 and BTF2) packed with polyurethane foam. Two different inoculum sources were used: a pure culture of Pseudomonas sp...
  80. Zhou W, Chung Y, PARRILLA CASTELLAR E, Zheng Y, Chung H, Bandle R, et al. Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J Pathol. 2016;186:701-15 pubmed publisher
    ..far upstream element binding protein (FBP) binds and activates the MYC promoter when far upstream element is via TFIIH helicase activity early in the transcription cycle. The fundamental biology and pathology of FBP are complex...
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    ..Interestingly, telomeric NAIP and telomeric GTF2H2 showed similar tendencies...
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    ..for centuries, has been shown to be an irreversible inhibitor of the XPB subunit of the transcription factor TFIIH and initiation of RNA polymerase?II mediated transcription...
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    ..When bound to Xpd and TFIIH, the CAK subunit Cdk7 phosphorylates transcriptional targets and not cell cycle Cdks...
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    ..Mutations in the cDNA have been identified in CS-A cell lines. CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH...
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    ..of HIV Tat-dependent transcription by targeting the general transcription and DNA repair factor II human (TFIIH) has not been reported...
  86. Andersen S, Zhang A, Dominska M, Moriel Carretero M, Herrera Moyano E, Aguilera A, et al. High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. PLoS Genet. 2016;12:e1005938 pubmed publisher
    The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH complex involved in both nucleotide excision repair (NER) and transcription...
  87. Jawhari A, Laine J, Dubaele S, Lamour V, Poterszman A, Coin F, et al. p52 Mediates XPB function within the transcription/repair factor TFIIH. J Biol Chem. 2002;277:31761-7 pubmed
    To further our understanding of the transcription/DNA repair factor TFIIH, we investigated the role of its p52 subunit in TFIIH function...
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    ..In addition, the complex is also an essential component of general transcription factor TFIIH which controls transcription via activating RNA polymerase II by serines 5 and 7 phosphorylation of the carboxyl-..
  89. Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt D, et al. The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. Nucleic Acids Res. 2017;45:10872-10883 pubmed publisher
    The general transcription factor IIH (TFIIH) is a multi-protein complex and its 10 subunits are engaged in an intricate protein-protein interaction network critical for the regulation of its transcription and DNA repair activities that ..
  90. Rüthemann P, Balbo Pogliano C, Codilupi T, Garajova Z, Naegeli H. Chromatin remodeler CHD1 promotes XPC-to-TFIIH handover of nucleosomal UV lesions in nucleotide excision repair. EMBO J. 2017;36:3372-3386 pubmed publisher
    ..analyses further demonstrate that CHD1 facilitates substrate handover from XPC to the downstream TFIIH (transcription factor IIH)...
  91. Qian H, Cheng Y, Yang C, Wu S, Zeng G, Xi J. Performance and biofilm characteristics of biotrickling filters for ethylbenzene removal in the presence of saponins. Environ Sci Pollut Res Int. 2018;25:30021-30030 pubmed publisher
    ..1 to 60.8% and from 69.4 to 44.2% for BTF1 and BTF2 in which saponin was and was not added, respectively. The corresponding RE declined from 91.1 to 40.8% and from 71...
  92. van der Steege G, Draaijers T, Grootscholten P, Osinga J, Anzevino R, Velonà I, et al. A provisional transcript map of the spinal muscular atrophy (SMA) critical region. Eur J Hum Genet. 1995;3:87-95 pubmed
    ..showed complete identity to the genes for cyclin B1 (CCNB1), the p44 subunit of the transcription factor BTF2 (BTF2p44), and cofilin (CFL)...