GTF2A1L

Summary

Gene Symbol: GTF2A1L
Description: general transcription factor IIA subunit 1 like
Alias: ALF, TFIIA-alpha and beta-like factor, GTF2A1-like factor, TFIIA large subunit isoform ALF, TFIIA-alpha/beta-like factor, general transcription factor II A, 1-like factor, general transcription factor IIA 1-like, testis secretory sperm-binding protein Li 230m
Species: human
Products:     GTF2A1L

Top Publications

  1. Liu L, Xiao D, Yu J, Shen R, Wang M, Li Q. Clinical course of sporadic acute hepatitis E in a hepatitis B virus endemic region. Int J Infect Dis. 2018;70:107-114 pubmed publisher
    ..1% (28/680) with acute liver failure (ALF) and 9.0% (61/680) with acute-on-chronic liver failure (ACLF)...
  2. Lv H, Hong L, Tian Y, Yin C, Zhu C, Feng H. Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway. Cell Commun Signal. 2019;17:2 pubmed publisher
    Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress...
  3. Norrman E, Bergh C, Wennerholm U. Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Hum Reprod. 2015;30:205-13 pubmed publisher
    ..No conflict of interest was reported. The study was supported by grants from Swedish Association of Local Authorities and Regions and by grants from the University of Gothenburg/Sahlgrenska University hospital (LUA/ALF 70940).
  4. Zhang Z, Zhu W, Ren H, Zhao X, Wang S, Ma H, et al. Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure. Stem Cell Res Ther. 2017;8:70 pubmed publisher
    Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms...
  5. Lyu Z, Ji X, Chen G, An B. Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress. Int Immunopharmacol. 2019;72:348-357 pubmed publisher
    ..the protective effects of ACD on lipopolysaccharide (LPS) and d-galactosamine (GalN)-induced acute liver failure (ALF) as well as the underlying molecular mechanisms remain unclear...
  6. Zhang J, Zhang S, Bi J, Gu J, Deng Y, Liu C. Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice. Int Immunopharmacol. 2017;45:26-33 pubmed publisher
    ..However, accidental or intentional APAP overdoses induce liver injury and even acute liver failure (ALF)...
  7. Lei Y, Yang L, Li W, Luo P, Zheng P. Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. World J Gastroenterol. 2015;21:13055-63 pubmed publisher
    ..a well-characterized mouse model of D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver failure (ALF)...
  8. López M, Uribe Cruz C, Osvaldt A, Kieling C, Simon L, Tobar S, et al. Encapsulated platelets modulate kupffer cell activation and reduce oxidative stress in a model of acute liver failure. Liver Transpl. 2016;22:1562-1572 pubmed publisher
    Acute liver failure (ALF) is characterized by massive hepatocyte cell death. Kupffer cells (KC) are the first cells to be activated after liver injury...
  9. Liu J, Zhang Q, Yu L, Liu B, Li M, Zhu R. Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice. World J Gastroenterol. 2015;21:5465-72 pubmed publisher
    ..Furthermore, data shows that PCB could improve the survival rate of acute liver failure (ALF) mice which were injected with a lethal dose of CCl4 (60.0% vs 20.0%)...

More Information

Publications144 found, 100 shown here

  1. Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Åkerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed publisher
    ..S.-V and M.M.); Adlerbert Research Foundation; Swedish federal government under the LUA/ALF agreement ALFFGBG-136481 and 429501 and the Regional Research and Development agreement (VGFOUREG-5171, -11296 and -..
  2. de Freitas Souza B, Nascimento R, de Oliveira S, Vasconcelos J, Kaneto C, de Carvalho L, et al. Transplantation of bone marrow cells decreases tumor necrosis factor-? production and blood-brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease. Cytotherapy. 2012;14:1011-21 pubmed publisher
    Acute liver failure (ALF), although rare, remains a rapidly progressive and frequently fatal condition. Acetaminophen (APAP) poisoning induces a massive hepatic necrosis and often leads to death as a result of cerebral edema...
  3. He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, et al. Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. Int Immunopharmacol. 2019;68:171-178 pubmed publisher
    Acute liver failure (ALF) is a distinct clinical syndrome with high mortality and characterized by metabolic derangements, neurological complication, and multiple failures...
  4. Xie J, Liu J, Chen T, Lan Q, Zhang Q, Liu B, et al. Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. World J Gastroenterol. 2015;21:5473-81 pubmed publisher
    ..Furthermore, DHM could significantly improve the survival rate of acute liver failure (ALF) mice (73.3% vs 20.0%, P < 0.0001), and SP600125 could inhibit the effect of DHM...
  5. Rao J, Zhang C, Wang P, Lu L, Qian X, Qin J, et al. C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure. Biochem J. 2015;466:369-78 pubmed publisher
    ..reactive oxygen species (ROS), which play a prominent role in hepatocellular death during acute liver failure (ALF). However, little is known about how CHOP facilitates ROS-induced hepatocellular injury...
  6. Dias Costa F, Moinho R, Ferreira S, Garcia P, Diogo L, Goncalves I, et al. [Acute liver failure related to inherited metabolic diseases in young children]. An Pediatr (Barc). 2018;88:69-74 pubmed publisher
    Pediatric acute liver failure (ALF) due to inherited metabolic diseases (IMD) is a rare life-threatening condition with a poor prognosis. Early intervention may be lifesaving...
  7. Martianov I, Velt A, Davidson G, Choukrallah M, Davidson I. TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression. Sci Rep. 2016;6:32069 pubmed publisher
    ..We show here that Trf2 forms a stable complex with TFIIA or the testis expressed paralogue ALF chaperoned in the cytoplasm by heat shock proteins...
  8. Wang W, Wu L, Li Q, Zhang Z, Xu L, Lin C, et al. Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling. Biomed Pharmacother. 2018;103:1137-1145 pubmed publisher
    ..effect of MA in the treatment of lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced acute liver failure(ALF) in mice. We hypothesized that MA administration may decrease the degree of liver injury caused by LPS/D-GalN...
  9. Obara Michlewska M, Ruszkiewicz J, Zielińska M, Verkhratsky A, Albrecht J. Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure. Neurochem Int. 2015;88:20-5 pubmed publisher
    ..extracellular glutamate (Glu) accumulation, including hepatic encephalopathy related to acute liver failure (ALF)...
  10. Wang Q, Dai X, Yang W, Wang H, Zhao H, Yang F, et al. Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells. Int Immunopharmacol. 2015;25:340-52 pubmed publisher
    Alcoholic liver fibrosis (ALF) is characterized by hyperplasia of extracellular matrix under long-term alcohol stimulation. Hepatic stellate cell (HSC) activation plays an important role in promoting hepatic fibrogenesis...
  11. Zhang Q, Yang F, Li X, Zhang H, Chu X, Zhang H, et al. Trichostatin A protects against intestinal injury in rats with acute liver failure. J Surg Res. 2016;205:1-10 pubmed publisher
    ..The aim of the present study was to elucidate the protective effects of TSA on acute liver failure (ALF) in rats and its potential mechanism...
  12. Bi Y, Li J, Yang Y, Wang Q, Wang Q, Zhang X, et al. Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice. Stem Cell Res Ther. 2019;10:22 pubmed publisher
    Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important...
  13. Londino J, Lazrak A, Collawn J, Bebok Z, Harrod K, Matalon S. Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae. Am J Physiol Lung Cell Mol Physiol. 2017;313:L845-L858 pubmed publisher
    ..the optimum volume and ionic composition of the bronchial periciliary fluid (PCL) and alveolar lining fluid (ALF) layers...
  14. Lindgren I, Bååth M, Uvebrant K, Dejmek A, Kjaer L, Henic E, et al. Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization. Hum Reprod. 2016;31:672-83 pubmed publisher
    ..This work was supported by Interreg IV A, EU (grant 167158) and ALF governments grant (F2014/354). Merck-Serono (Darmstadt, Germany) supported the enrollment of the subjects...
  15. Sarges P, Steinberg J, Lewis J. Drug-Induced Liver Injury: Highlights from a Review of the 2015 Literature. Drug Saf. 2016;39:801-21 pubmed publisher
    ..determine the prognosis and outcome of patients with paracetamol (acetaminophen [AAP])-induced acute liver failure (ALF), and may be of great benefit in deciding who requires N-acetylcysteine (NAC), and for what duration...
  16. Xu X, Yu B, Zhu B, Ren H, Feng Z. [Clinical application of blood purification (artificial liver) in treatment of acute liver failure in children]. Zhonghua Er Ke Za Zhi. 2014;52:433-7 pubmed
    ..The inconsistency between serum bilirubin and ALT levels was an important factor that suggested poor prognosis of ALF, and it might increase survival rate to use BP therapy before that inconsistency emerged.
  17. Weiss N, Mochel F, Rudler M, Demeret S, Lebray P, Conti F, et al. Peak hyperammonemia and atypical acute liver failure: The eruption of an urea cycle disorder during hyperemesis gravidarum. J Hepatol. 2017;: pubmed publisher
    ..weeks pregnant, affected by hyperemesis gravidarum developed acute liver injury (ALI) and then acute liver failure (ALF) in less than 48?h...
  18. Sun W, Zhang X, Wan W, Wang S, Wen X, Zheng H, et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in anti-lipopolysaccharide factors (ALFs) gene expression in mud crab. Dev Comp Immunol. 2017;67:361-376 pubmed publisher
    ..response to immune challenges and the inhibition of SpALFs gene expression indicate that Sp-TRAF6 plays an important role in host defense against pathogen invasions via regulation of ALF gene expression in S. paramamosain.
  19. Lv H, Fan X, Wang L, Feng H, Ci X. Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy. Int J Biol Macromol. 2018;119:240-248 pubmed publisher
    Acute liver failure (ALF), an inflammation-mediated hepatocellular injury process, is a life-threatening and fatal clinical syndrome...
  20. Sutti S, Tacke F. Liver inflammation and regeneration in drug-induced liver injury: sex matters!. Clin Sci (Lond). 2018;132:609-613 pubmed publisher
    ..efforts have been devoted to unravel the risk factors responsible for DILI worsening toward acute liver failure (ALF), liver transplantation (LT), and/or death...
  21. Gong X, Yang Y, Huang L, Zhang Q, Wan R, Zhang P, et al. Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice. Int Immunopharmacol. 2017;46:124-132 pubmed publisher
    To evaluate the hepatoprotective effects and potential mechanisms of paeonol (Pae) against acute liver failure (ALF) induced by lipopolysaccharide (LPS)/d-galactosamine (d-GalN) in mice, we examined anti-oxidative, anti-inflammatory and ..
  22. Xu L, Zheng X, Wang Y, Fan Q, Zhang M, Li R, et al. Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis. Eur J Pharmacol. 2018;819:161-168 pubmed publisher
    Acute liver failure (ALF) is characterized by sudden large area of inflammation and extensive hepatocyte apoptosis. This study identified the natural product berberine as a potential agent for acute liver failure(ALF)...
  23. Huang Y, Chen P, Lee C, Yang S, Lin M, Lee H, et al. Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression. J Biomed Sci. 2016;23:5 pubmed publisher
    Acetaminophen (APAP) overdose causes acute liver failure (ALF) in animals and humans via the rapid depletion of intracellular glutathione (GSH) and the generation of excess reactive oxygen species (ROS) that damage hepatocytes...
  24. Kuhla A, Thrum M, Schaeper U, Fehring V, Schulze Topphoff U, Abshagen K, et al. Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury. Apoptosis. 2015;20:500-11 pubmed publisher
    Acute liver failure (ALF) is a life threatening disease for which only few treatment options exist...
  25. Seo M, Hong J, Kim S, Lee S. Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling. Eur J Pharmacol. 2017;812:128-137 pubmed publisher
    Acute liver failure (ALF) is a life-threatening syndrome resulting from massive inflammation and hepatocyte death...
  26. Wilson W, Lowman D, Antony S, Puthumana J, Bright Singh I, Philip R. Immune gene expression profile of Penaeus monodon in response to marine yeast glucan application and white spot syndrome virus challenge. Fish Shellfish Immunol. 2015;43:346-56 pubmed publisher
    ..anti-lipopolysaccharide factor (ALF), crustin-1, crustin-2, crustin-3, penaeidin-3 and penaeidin-5 and 13 immune genes viz...
  27. Basta G, Del Turco S, Navarra T, Lee W. Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure. Liver Transpl. 2015;21:847-54 pubmed publisher
    ..Sixty well-characterized acetaminophen-related acute liver failure (ALF) patients (30 spontaneous survivors and 30 patients who underwent transplantation and/or died) who were enrolled in ..
  28. Bhushan B, Poudel S, Manley M, Roy N, Apte U. Inhibition of Glycogen Synthase Kinase 3 Accelerated Liver Regeneration after Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2017;187:543-552 pubmed publisher
    Overdose of acetaminophen (APAP) is the leading cause of acute liver failure (ALF) in the United States...
  29. Han B, Shi X, Zhang Y, Gu Z, Yuan X, Ren H, et al. No transmission of porcine endogenous retrovirus in an acute liver failure model treated by a novel hybrid bioartificial liver containing porcine hepatocytes. Hepatobiliary Pancreat Dis Int. 2015;14:492-501 pubmed
    ..by detecting the transmission of porcine endogenous retroviruses (PERVs) into canines with acute liver failure (ALF) undergoing HBAL...
  30. Kumar A, Sharma S, Kar P, Agarwal S, Ramji S, Husain S, et al. Impact of maternal nutrition in hepatitis E infection in pregnancy. Arch Gynecol Obstet. 2017;296:885-895 pubmed publisher
    ..The jaundiced patients were classified as acute viral hepatitis (AVH) or acute liver failure (ALF)...
  31. Liu X, Hu B, Wang F, Song Y, Fan Z, Wei H, et al. Molecular cloning of the rabbit interleukin 6 promoter: Functional characterization of rabbit hemorrhagic disease virus response elements in RK-13 cells. Dev Comp Immunol. 2016;65:280-288 pubmed publisher
    Infection with rabbit hemorrhagic disease virus (RHDV) can cause acute liver failure (ALF), leading to severe mortality in rabbits...
  32. Ma H, Shi X, Yuan X, Ding Y.  IL-1β siRNA adenovirus benefits liver regeneration by improving mesenchymal stem cells survival after acute liver failure. Ann Hepatol. 2016;15:260-70 pubmed publisher
    ..effect of IL-1? siRNA adenovirus on MSC and the therapeutic effect of MSC combined with IL-1? siRNA adenovirus in ALF. We implanted MSC or/and IL-1? siRNA adenovirus via the tail vein, using CCl4-induced ALF in a mice model...
  33. Boschi S, Lee J, Beykan S, Slavik R, Wei L, Spick C, et al. Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand. Eur J Nucl Med Mol Imaging. 2016;43:2122-2130 pubmed
    ..Several conditions for the labeling of 18F-PSMA-11 via 18F-AlF-complexation were screened to study the influence of reaction temperature, peptide amount, ethanol volume, and ..
  34. Balogh O, Roch M, Keller S, Michel E, Reichler I. The use of semi-quantitative tests at Cesarean section delivery for the differentiation of canine fetal fluids from maternal urine on the basis of biochemical characteristics. Theriogenology. 2017;88:174-182 pubmed publisher
    ..Maternal urine, and amniotic fluid (AMF) and allantoic fluid (ALF) from only one fetus per bitch, were collected intraoperatively during Cesarean section...
  35. You H, Lattmann S, Rhodes D, Yan J. RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis. Nucleic Acids Res. 2017;45:206-214 pubmed publisher
    ..Importantly, our results show that the ADP·AlF[Formula: see text]-bound RHAU does not stabilize the G4...
  36. Yang H, Li S, Li F, Xiang J. Structure and Bioactivity of a Modified Peptide Derived from the LPS-Binding Domain of an Anti-Lipopolysaccharide Factor (ALF) of Shrimp. Mar Drugs. 2016;14: pubmed publisher
    The lipopolysaccharide binding domain (LBD) in anti-lipopolysaccharide factor (ALF) is the main functional element of ALF, which exhibits antimicrobial activities...
  37. Khamri W, Abeles R, Hou T, Anderson A, El Masry A, Triantafyllou E, et al. Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Gastroenterology. 2017;153:263-276.e8 pubmed publisher
    Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis...
  38. Xie W, Han S, Khan M, DeJong J. Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. J Biol Chem. 2002;277:17765-74 pubmed
    b>ALF (TFIIAalpha/beta-like factor) is a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA...
  39. Stravitz R, Ellerbe C, Durkalski V, Reuben A, Lisman T, Lee W. Thrombocytopenia Is Associated With Multi-organ System Failure in Patients With Acute Liver Failure. Clin Gastroenterol Hepatol. 2016;14:613-620.e4 pubmed publisher
    Acute liver failure (ALF) is a syndrome characterized by an intense systemic inflammatory response (SIRS) and multi-organ system failure (MOSF)...
  40. Kumarasena R, Niriella M, Ranawaka C, Miththinda J, De Silva A, Dassanayaka A, et al. Predicting acute liver failure in dengue infection. Ceylon Med J. 2016;61:35-6 pubmed publisher
    ..involving 240 patients with dengue infection, we attempted to identify early predictors of acute liver failure (ALF)...
  41. Diaz G, Zamboni F, Tice A, Farci P. Integrated ordination of miRNA and mRNA expression profiles. BMC Genomics. 2015;16:767 pubmed publisher
    ..were calculated between miRNAs and mRNAs differentially expressed in livers of patients with acute liver failure (ALF) using normal livers as controls...
  42. Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, et al. Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. J Hepatol. 2016;65:552-9 pubmed publisher
    ..A dramatic upregulation (>200times) was observed in patients with acute liver failure (ALF) and end-stage primary biliary cholangitis (PBC)...
  43. Blandino Ortiz A, Lamanna I, Antonucci E, Pozzebon S, Dell Anna A, Vincent J, et al. Altered liver function in patients undergoing veno-arterial extracorporeal membrane oxygenation (ECMO) therapy. Minerva Anestesiol. 2017;83:255 - 265 pubmed publisher
    ..Elevated liver enzymes (ELE) were defined if AST and/or ALT were > 200 UI/L, and acute liver failure (ALF) as the presence of an INR ? 1.5, new onset encephalopathy and an elevated total bilirubin concentrations...
  44. Löfstedt A, Chiang S, Onelöv E, Bryceson Y, Meeths M, Henter J. Cancer risk in relatives of patients with a primary disorder of lymphocyte cytotoxicity: a retrospective cohort study. Lancet Haematol. 2015;2:e536-42 pubmed publisher
    ..Foundation, Swedish Research Council, Histiocytosis Association, Swedish Cancer Society, Swedish Cancer and Allergy Foundation, Mary Béve Foundation, Karolinska Institutet Research Foundation, Stockholm County Council (ALF-project).
  45. Olivo R, Guarrera J, Pyrsopoulos N. Liver Transplantation for Acute Liver Failure. Clin Liver Dis. 2018;22:409-417 pubmed publisher
    With the advent of liver transplant for acute liver failure (ALF), survival rate has improved drastically. Liver transplant for ALF accounts for 8% of all transplant cases...
  46. Bunchorntavakul C, Reddy K. Acute Liver Failure. Clin Liver Dis. 2017;21:769-792 pubmed publisher
    Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early recognition and prompt initiation of etiology-specific therapy, intensive care protocols, and liver transplantation (LT)...
  47. Sun Y, Sun D, Gong R, Zhong X, Liu X, Meng X. Relationship between ncRNAs and gastric cancer: meta-analysis. Bratisl Lek Listy. 2017;118:535-538 pubmed publisher
    This study was designed to investigate the action and mechanism of cordyceps polysaccharide on rat acute liver failure (ALF).
  48. Beck Z, Matyas G, Jalah R, Rao M, Polonis V, Alving C. Differential immune responses to HIV-1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21. Vaccine. 2015;33:5578-5587 pubmed publisher
    ..A particular type of liposomal construct, referred to as Army Liposome Formulation (ALF), containing neutral and anionic saturated phospholipids, cholesterol, and monophosphoryl lipid A (MPLA), has been ..
  49. Majumdar M, Ratho R, Chawla Y, Singh M. Role of TLR gene expression and cytokine profiling in the immunopathogenesis of viral hepatitis E. J Clin Virol. 2015;73:8-13 pubmed publisher
    ..of Hepatitis E virus (HEV) range from self-limiting acute viral hepatitis (AVH) to acute liver failure (ALF). The varied clinical course is thought to be immune-mediated...
  50. Mishra A, Rustgi V. Prognostic Models in Acute Liver Failure. Clin Liver Dis. 2018;22:375-388 pubmed publisher
    There is a strong imperative to develop valid and accurate prognostic modeling for acute liver failure (ALF)...
  51. Wang J, Sun Z, Jiang J, Wu D, Liu X, Xie Z, et al. Proteomic Signature of Acute Liver Failure: From Discovery and Verification in a Pig Model to Confirmation in Humans. Mol Cell Proteomics. 2017;16:1188-1199 pubmed publisher
    Acute liver failure (ALF) is a fatal condition hallmarked by rapid development. The present study aimed to describe the dynamic alterations of serum proteins associated with ALF development, and to seek for novel biomarkers of ALF...
  52. McGill M, Du K, Weemhoff J, Jaeschke H. Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food Chem Toxicol. 2015;86:309-18 pubmed publisher
    ..Drug-induced liver injury, for example, is the most common cause of acute liver failure (ALF) and ALF-induced deaths in many countries...
  53. Liu Y, Zai J, Li X, Ma Z, Qian X. Al2O3 coated metal sulfides: one-pot synthesis and enhanced lithium storage stability via localized in situ conversion reactions. Dalton Trans. 2017;46:1260-1265 pubmed publisher
    ..The conversion of Al2O3 to ion-conductive AlF3 can enhance the quick charge transfer process of the lithium ion insertion/extraction reaction...
  54. Ulbrich F, Hagmann C, Buerkle H, Romão C, Schallner N, Goebel U, et al. The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats' retinal ganglion cells after ischemia and reperfusion injury. J Neuroinflammation. 2017;14:130 pubmed publisher
    ..In this investigation, we aimed to analyze the effects of the CORM ALF-186 on neuro-inflammation and hypothesized that the soluble guanylate cyclase (sGC) is playing a decisive role...
  55. Zhang H, Liu N, Gao S, Hu X, Zhao W, Tao R, et al. Can an ¹⁸F-ALF-NOTA-PRGD2 PET/CT Scan Predict Treatment Sensitivity to Concurrent Chemoradiotherapy in Patients with Newly Diagnosed Glioblastoma?. J Nucl Med. 2016;57:524-9 pubmed publisher
    This study examined the value of a novel 1-step labeled integrin α(v)β3-targeting (18)F-AlF-NOTA-PRGD2 (denoted as (18)F-RGD) scan in assessing sensitivity to concurrent chemoradiotherapy (CCRT) in patients with newly diagnosed ..
  56. Silva V, Secolin R, Vemuganti R, Lopes Cendes I, Hazell A. Acute liver failure is associated with altered cerebral expression profiles of long non-coding RNAs. Neurosci Lett. 2017;656:58-64 pubmed publisher
    Hepatic encephalopathy (HE) represents a serious complication of acute liver failure (ALF) in which cerebral edema leading to brainstem herniation as a result of increased intracranial hypertension is a major consequence...
  57. Yi X, Qiao S, Ma L, Wang J, Ruan J. Soil fluoride fractions and their bioavailability to tea plants (Camellia sinensis L.). Environ Geochem Health. 2017;39:1005-1016 pubmed publisher
    ..The significant correlations among some of the F fractions suggested that F in solution, AlF complexes (AlF2+, AlF2+) and those bound to organic matter likely represent the ..
  58. Bavikatte A, Sudhindran S, Dhar P, Sudheer O, Unnikrishnan G, Balakrishnan D, et al. Live donor liver transplantation for antitubercular drug-induced acute liver failure. Indian J Gastroenterol. 2017;36:56-61 pubmed publisher
    ..liver transplantation, however it might be the only lifesaving option to certain patients of acute liver failure (ALF) due to ATT. We have assessed the outcome of live donor liver transplantation in ATT-induced ALF...
  59. Beck Z, Torres O, Matyas G, Lanar D, Alving C. Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex. J Control Release. 2018;275:12-19 pubmed publisher
    ..In this study we examined whether adsorption of Army Liposome Formulation (ALF) to an aluminum salt that already has an antigen adsorbed to it might result in improved immune potency of the ..
  60. Mishra S, Borkakoti J, Kumar S, Kar P. Role of HEV antigen detection in HEV-related acute viral hepatitis and acute liver failure. J Med Virol. 2016;88:2179-2185 pubmed publisher
    ..available diagnostic tests in patients of HEV-related acute viral hepatitis (AVH) and acute liver failure (ALF). This study included 36 ALF and 64 AVH cases...
  61. Atherton K, Nobre A, Lázár A, Wulff K, Whittaker R, Dhawan V, et al. Slow wave sleep and accelerated forgetting. Cortex. 2016;84:80-89 pubmed publisher
    ..typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy...
  62. Hoefeijzers S, Zeman A, Della Sala S, Dewar M. Capturing real-life forgetting in transient epileptic amnesia via an incidental memory test. Cortex. 2019;110:47-57 pubmed publisher
    ..tests that include a 1-3 week delay period frequently reveal clear evidence of 'accelerated long-term forgetting' (ALF). However, they are not used routinely and lack ecological validity...
  63. Liu M, Xu Y, Han X, Yin L, Xu L, Qi Y, et al. Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway. Sci Rep. 2015;5:18038 pubmed publisher
    ..work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF)...
  64. Fujiwara K, Yasui S, Yonemitsu Y, Arai M, Kanda T, Fukuda Y, et al. Analysis of infectious complications and timing for emergency liver transplantation in autoimmune acute liver failure. J Hepatobiliary Pancreat Sci. 2016;23:212-9 pubmed publisher
    Autoimmune hepatitis (AIH) is one of major etiologies of acute liver failure (ALF), and the survival rate without liver transplantation (LT) of patients with fulminant AIH is especially poor worldwide...
  65. Rodrigues R, Heymans A, De Boe V, Sachinidis A, Chaudhari U, Govaere O, et al. Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems. Toxicol Lett. 2016;240:50-9 pubmed publisher
    ..APAP) exposure is compared to data obtained from patients suffering from APAP-induced acute liver failure (ALF)...
  66. Han K, Trinkoff A, Storr C, Lerner N, Yang B. Variation Across U.S. Assisted Living Facilities: Admissions, Resident Care Needs, and Staffing. J Nurs Scholarsh. 2017;49:24-32 pubmed publisher
    ..the United States currently reside in assisted living facilities (ALFs) than nursing homes, little is known about ALF admission policies, resident care needs, and staffing characteristics...
  67. Phan T, Beare R, Chen J, Clissold B, Ly J, Singhal S, et al. Googling Service Boundaries for Endovascular Clot Retrieval Hub Hospitals in a Metropolitan Setting: Proof-of-Concept Study. Stroke. 2017;48:1353-1361 pubmed publisher
    ..clot retrieval-capable hubs (Royal Melbourne Hospital [RMH], Monash Medical Center [MMC], Alfred Hospital [ALF], and Austin Hospital [AUS]) estimated using Google Map application program interface...
  68. Hill P, Scordo J, Arcos J, Kirkby S, Wewers M, Wozniak D, et al. Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells. Sci Rep. 2017;7:4761 pubmed publisher
    ..aeruginosa enters the terminal bronchioles and alveoli and comes into contact with alveolar lining fluid (ALF), which contains homeostatic and antimicrobial hydrolytic activities, termed hydrolases...
  69. Thiel K, Schenk M, Sipos B, Sperveslage J, Peter A, Morgalla M, et al. Acute liver failure after amanitin poisoning: a porcine model to detect prognostic markers for liver regeneration. Hepatol Int. 2014;8:128-36 pubmed publisher
    ..This study aimed to investigate markers indicating spontaneous liver regeneration in a porcine acute liver failure (ALF) model after α-amanitin intoxication. German landrace pigs received either 0...
  70. Byk K, Jasiński K, Bartel Z, Jasztal A, Sitek B, Tomanek B, et al. MRI-based assessment of liver perfusion and hepatocyte injury in the murine model of acute hepatitis. MAGMA. 2016;29:789-798 pubmed
    ..in perfusion and liver function in the concanavalin A (ConA)-induced mouse model of acute liver failure (ALF) using two magnetic resonance imaging (MRI)-based methods: dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA ..
  71. Guidi S, Noè M, Riello P, Perosa A, Selva M. Towards a Rational Design of a Continuous-Flow Method for the Acetalization of Crude Glycerol: Scope and Limitations of Commercial Amberlyst 36 and AlF₃·3H₂O as Model Catalysts. Molecules. 2016;21: pubmed publisher
    ..of an already known acetalization catalyst such as Amberlyst 36 (A36), and aluminum fluoride three hydrate (AlF₃·3H₂O, AF) whose use was never previously reported for the synthesis of acetals...
  72. Di Giorgio A, Sonzogni A, Piccichè A, Alessio G, Bonanomi E, Colledan M, et al. Successful management of acute liver failure in Italian children: A 16-year experience at a referral centre for paediatric liver transplantation. Dig Liver Dis. 2017;49:1139-1145 pubmed publisher
    Identifying the causes of acute liver failure (ALF) and predictors of death or liver transplantation (LTX) is crucial to decide its management. We aimed to describe features and outcome of ALF in Italian children...
  73. Elzoghby A, Vranic B, Samy W, Elgindy N. Swellable floating tablet based on spray-dried casein nanoparticles: Near-infrared spectral characterization and floating matrix evaluation. Int J Pharm. 2015;491:113-22 pubmed publisher
    In this study, spray-dried alfuzosin hydrochloride (ALF)-loaded casein (CAS) nanoparticles were successfully used for the preparation of a swellable floating matrix via direct compression...
  74. Bémeur C, Cudalbu C, Dam G, Thrane A, Cooper A, Rose C. Brain edema: a valid endpoint for measuring hepatic encephalopathy?. Metab Brain Dis. 2016;31:1249-1258 pubmed
    ..astrocytes which consequently leads to brain edema, a common feature found in patients with acute liver failure (ALF) as well as in cirrhotic patients suffering from HE...
  75. Eugenio Pérez D, Montes de Oca Solano H, Pedraza Chaverri J. Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity. Pharm Biol. 2016;54:2340-52 pubmed publisher
    ..safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose...
  76. Kortüm F, Marquardt I, Alawi M, Korenke G, Spranger S, Meinecke P, et al. Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. Pediatrics. 2017;139: pubmed publisher
    Acute liver failure (ALF) is a life-threatening condition in the absence of preexisting liver disease in children. The main clinical presentation comprises hepatic dysfunction, elevated liver biochemical values, and coagulopathy...
  77. Yan B, Yang B, Li H, Zhang Y, Pei F, Zhu A, et al. The therapeutic effect of CORM-3 on acute liver failure induced by lipopolysaccharide/D-galactosamine in mice. Hepatobiliary Pancreat Dis Int. 2016;15:73-80 pubmed
    Acute liver failure (ALF) is a severe and life-threatening clinical syndrome resulting in a high mortality and extremely poor prognosis...
  78. Fanfani F, Restaino S, Rossitto C, Gueli Alletti S, Costantini B, Monterossi G, et al. Total Laparoscopic (S-LPS) versus TELELAP ALF-X Robotic-Assisted Hysterectomy: A Case-Control Study. J Minim Invasive Gynecol. 2016;23:933-8 pubmed publisher
    To compare the feasibility and safety of the TELELAP ALF-X system and standard laparoscopy for total hysterectomy to treat patients with benign and early malignant gynecologic disease...
  79. Shalimar -, Kedia S, Gunjan D, Sonika U, Mahapatra S, Nayak B, et al. Acute Liver Failure Due to Hepatitis E Virus Infection Is Associated with Better Survival than Other Etiologies in Indian Patients. Dig Dis Sci. 2017;62:1058-1066 pubmed publisher
    Hepatitis E virus (HEV) is a global disease and an important cause of acute liver failure (ALF) in the Indian subcontinent...
  80. Kawashima Kumagai K, Yamashiro K, Yoshikawa M, Miyake M, Ming G, Fan Q, et al. A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep. 2017;7:7173 pubmed publisher
    ..0 × 10-5, STON1-GTF2A1L/LHCGR/FSHR, PLXNA1, CTNNA3, ARMS2/HTRA1, LHFP, and FLJ38725...
  81. Swaminathan S, Huentelman M, Corneveaux J, Myers A, Faber K, Foroud T, et al. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. PLoS ONE. 2012;7:e50640 pubmed publisher
    ..006, odds ratio = 3.986 (95% confidence interval 1.490-10.667)). A novel APP gene duplication was observed in one case sample. Further investigation of the identified genes in independent and larger samples is warranted. ..
  82. Czepielewski R, Jaeger N, Marques P, Antunes M, Rigo M, Alvarenga D, et al. GRPR antagonist protects from drug-induced liver injury by impairing neutrophil chemotaxis and motility. Eur J Immunol. 2017;47:646-657 pubmed publisher
    Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF), where hepatocyte necrotic products trigger liver inflammation, release of CXC chemokine receptor 2 (CXCR2) ligands (IL-8) and other neutrophil chemotactic ..
  83. Scordo J, Arcos J, Kelley H, Diangelo L, Sasindran S, Youngmin E, et al. Mycobacterium tuberculosis Cell Wall Fragments Released upon Bacterial Contact with the Human Lung Mucosa Alter the Neutrophil Response to Infection. Front Immunol. 2017;8:307 pubmed publisher
    ..We published that human lung mucosa, or alveolar lining fluid (ALF), contains an array of hydrolytic enzymes that can significantly alter the M...
  84. Liu Y, Ma J, Zeng Q, Lv J, Xie X, Pan Y, et al. MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPAR? in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes. J Cell Biochem. 2018;119:358-365 pubmed publisher
    ..the potential involvement and regulatory mechanism of miR-19a in hepatocytes autophagy of acute liver failure (ALF)...
  85. Lauschke V. Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure. Clin Sci (Lond). 2017;131:2059-2062 pubmed publisher
    ..evidence that circulating miR-223 levels provide a promising minimally invasive biomarker for acute liver failure (ALF) that defines a distinct subset of ALF cases and correlates with clinical outcomes...
  86. Lee K, Baker L, Mallett S, Riddell A, Chowdary P, Alibhai H, et al. Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs. Sci Rep. 2017;7:9347 pubmed publisher
    ..prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists...
  87. Hang H, Liu X, Wang H, Xu N, Bian J, Zhang J, et al. Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival. Exp Cell Res. 2017;360:81-93 pubmed publisher
    ..of IHH overexpressing HNF4A could improve liver function and survival in rats with acute liver failure (ALF)...
  88. Košir A, Arulandhu A, Voorhuijzen M, Xiao H, Hagelaar R, Staats M, et al. ALF: a strategy for identification of unauthorized GMOs in complex mixtures by a GW-NGS method and dedicated bioinformatics analysis. Sci Rep. 2017;7:14155 pubmed publisher
    ..In this research, an adapted genome walking approach was developed, called ALF: Amplification of Linearly-enriched Fragments...
  89. Stravitz R, Gottfried M, Durkalski V, Fontana R, Hanje A, Koch D, et al. Safety, Tolerability and Pharmacokinetics of L-Ornithine Phenylacetate in Patients with Acute Liver Injury/Failure and Hyperammonemia. Hepatology. 2017;: pubmed publisher
    Cerebral edema remains a significant cause of morbidity and mortality in patients with acute liver failure (ALF) and has been linked to elevated blood ammonia levels...
  90. Rubin J, Hameed B, Gottfried M, Lee W, Sarkar M. Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. Clin Gastroenterol Hepatol. 2018;16:936-946 pubmed publisher
    Acetaminophen overdose is the leading cause of acute liver injury (ALI) and acute liver failure (ALF) in the developed world. Sex differences in acetaminophen-induced hepatotoxicity have not been described...
  91. Sang J, Shi X, Han B, Huang T, Huang X, Ren H, et al. Intraportal mesenchymal stem cell transplantation prevents acute liver failure through promoting cell proliferation and inhibiting apoptosis. Hepatobiliary Pancreat Dis Int. 2016;15:602-611 pubmed
    Transplantation of mesenchymal stem cells (MSCs) has been regarded as a potential treatment for acute liver failure (ALF), but the optimal route was unknown...
  92. Shi Z, Cao D, Tang W, Hu X, Wang Z. Abatement of tetrafluoromethane by chemical absorption with molten aluminum. J Environ Manage. 2017;204:375-382 pubmed publisher
    ..The products of the chemical absorption are white solid AlF3 and black graphite powder identified by XRD and SEM-EDS analysis...