GSTT1

Summary

Gene Symbol: GSTT1
Description: glutathione S-transferase theta 1
Alias: glutathione S-transferase theta-1, GST class-theta-1, glutathione transferase T1-1
Species: human
Products:     GSTT1

Top Publications

  1. Moore L, Boffetta P, Karami S, Brennan P, Stewart P, Hung R, et al. Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res. 2010;70:6527-36 pubmed publisher
    ..21; P(trend) = 0.02)]. A significant association was found among TCE-exposed subjects with at least one intact GSTT1 allele (active genotype; OR = 1.88; 95% CI, 1.06-3...
  2. Lam T, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao X, et al. Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev. 2009;18:184-95 pubmed publisher
    ..and lung cancer risk, with an emphasis on the potential interaction between cruciferous vegetables and GSTM1 and GSTT1 gene variants...
  3. Lam T, Ruczinski I, Helzlsouer K, Shugart Y, Li K, Clipp S, et al. Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study. Ann Epidemiol. 2009;19:546-52 pubmed publisher
    Previous studies did not discriminate wild-type from hemizygous genotypes of GSTM1 and GSTT1. In this study, we investigated wild-type, hemizygous deletion, and homozygous deletion genotypes of GSTM1 and GSTT1 and lung cancer risk...
  4. Ashtiani Z, Hasheminasab S, Ayati M, Goulian B, Modarressi M. Are GSTM1, GSTT1 and CAG repeat length of androgen receptor gene polymorphisms associated with risk of prostate cancer in Iranian patients?. Pathol Oncol Res. 2011;17:269-75 pubmed publisher
    We conducted this study to investigate whether CAG repeat length in androgen receptor gene and GSTM1 and GSTT1 polymorphisms influence prostate cancer risk in Iranian newly diagnosed cancer patients compared to age-matched BPH group and ..
  5. Singla N, Gupta D, Birbian N, Singh J. Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity. Tuberculosis (Edinb). 2014;94:293-8 pubmed publisher
    ..The genetic polymorphisms of the NAT2 and CYP2E1 genes were studied by PCR-RFLP and GSTM1 and GSTT1 were evaluated by multiplex PCR...
  6. Vojtková J, Durdik P, Ciljakova M, Michnová Z, Turcan T, Babusikova E. The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents. Cent Eur J Public Health. 2013;21:88-91 pubmed
    ..93; 95% CI = 1.061-8.095; p = 0.032). The study indicates that GST T1 null genotype and GST T1 null/M1 wild combination could be considered a risk factor for type 1 diabetes development in Slovak children and adolescents. ..
  7. Liu K, Zhang L, Lin X, Chen L, Shi H, Magaye R, et al. Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC) in Chinese population evaluated by an updated systematic meta-analysis. PLoS ONE. 2013;8:e57043 pubmed publisher
    Due to the possible involvement of Glutathione S-transferase Mu-1 (GSTM1) and Glutathione S-transferase theta-1 (GSTT1) in the detoxification of environmental carcinogens, environmental toxins, and oxidative stress products, genetic ..
  8. López Cima M, Álvarez Avellón S, Pascual T, Fernandez Somoano A, Tardon A. Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias. BMC Cancer. 2012;12:433 pubmed publisher
    ..We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms are related to the risk of developing lung cancer in relation to ..
  9. Gönül N, Kadioglu E, Kocabas N, Ozkaya M, Karakaya A, Karahalil B. The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: a case-control study in a Turkish population. Gene. 2012;505:121-7 pubmed publisher
    The aim of the present study was to investigate the role of some polymorphisms in GSTs (GSTM1, GSTT1 and GSTP1) which are very important protective mechanisms against oxidative stress and in OGG1 gene which is important in DNA repair, ..

More Information

Publications83

  1. Amer M, Ghattas M, Abo Elmatty D, Abou El Ela S. Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk. Genet Mol Res. 2011;10:3722-30 pubmed publisher
    ..Two polymorphisms were identified by multiplex PCR within the GST genes: GSTM1 and GSTT1. The proportion of the GSTT1- and GSTM1-null genotypes was significantly greater in diabetic patients when ..
  2. Ahmad S, Arjumand W, Seth A, Kumar Saini A, Sultana S. Impact of glutathione transferase M1, T1, and P1 gene polymorphisms in the genetic susceptibility of North Indian population to renal cell carcinoma. DNA Cell Biol. 2012;31:636-43 pubmed publisher
    ..The difference in frequency of the GSTT1 null genotype between cases and control subjects was statistically significant (active ver...
  3. Koh W, Nelson H, Yuan J, Van Den Berg D, Jin A, Wang R, et al. Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore. Carcinogenesis. 2011;32:1507-11 pubmed publisher
    ..We determined the deletion polymorphisms of GSTM1 and GSTT1 and the functional polymorphism at codon 105 of GSTP1 for each subject...
  4. Khan M, Micheal S, Akhtar F, Ahmed W, Ijaz B, Ahmed A, et al. The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population. Mol Vis. 2010;16:2146-52 pubmed
    The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients...
  5. Yuan L, Meng L, Ma W, Li S, Feng J, Yu H, et al. The role of glutathione S-transferase M1 and T1 gene polymorphisms and fruit and vegetable consumption in antioxidant parameters in healthy subjects. Br J Nutr. 2012;107:928-33 pubmed publisher
    ..There was correlation between plasma T-AOC and consumption of F&V in the GSTM1? or GSTT1? subjects. A similar pattern was evident for erythrocyte GST activity in the GSTM1? subjects...
  6. Sui Y, Han W, Yang Z, Jiang M, Li J. Association of glutathione S-transferase M1 and T1 null polymorphisms with the development of cervical lesions: a meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2011;159:443-8 pubmed publisher
    ..However, the glutathione S-transferase T1 null polymorphism does not appear to be a risk factor for cervical lesions in any population. ..
  7. Tang K, Xue W, Xing Y, Xu S, Wu Q, Liu R, et al. Genetic polymorphisms of glutathione S-transferase M1, T1, and P1, and the assessment of oxidative damage in infertile men with varicoceles from northwestern China. J Androl. 2012;33:257-63 pubmed publisher
    ..was to investigate the genetic polymorphisms of the glutathione S-transferase M1, T1, and P1 genes (GSTM1, GSTT1, and GSTP1) and to assess the oxidative damage in infertile men with varicoceles from northwestern China...
  8. Huang W, Wang W, Zhou M, Chen S, Zhang X. Association of glutathione S-transferase polymorphisms (GSTM1 and GSTT1) with primary open-angle glaucoma: an evidence-based meta-analysis. Gene. 2013;526:80-6 pubmed publisher
    ..Therefore, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on POAG risk...
  9. Lakhdar R, Denden S, Mouhamed M, Chalgoum A, Leban N, Knani J, et al. Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease. Exp Lung Res. 2011;37:195-204 pubmed publisher
    ..and polymorphisms of microsomal epoxide hydrolase X1 (EPHX1), glutathione S-transferase P1 (GSTP1), GSTM1, and GSTT1 in chronic obstructive pulmonary disease (COPD)...
  10. Guven M, Gorgun E, Unal M, Yenerel M, Batar B, Kucumen B, et al. Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration. Ophthalmic Res. 2011;46:31-7 pubmed publisher
    To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD)...
  11. Zhang J, Liu H, Yan H, Huang G, Wang B. Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis. Gene. 2013;518:405-11 pubmed publisher
    ..Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) genes are polymorphic in human and the null genotypes lead to the absence of enzyme function...
  12. Koh Y, Kim D, Park S, Jung S, Park E, Kim H, et al. GSTT1 copy number gain is a poor predictive marker for escalated-dose imatinib treatment in chronic myeloid leukemia: genetic predictive marker found using array comparative genomic hybridization. Cancer Genet Cytogenet. 2010;203:215-21 pubmed publisher
    ..072 and P = 0.070, respectively). For GSTT1, in 22q11.23, copy number gain was observed in patients without EMR (P = 0.035)...
  13. Cheng H, You H, Zhou T. Relationship between GSTM1/GSTT1 null genotypes and renal cell carcinoma risk: a meta-analysis. Ren Fail. 2012;34:1052-7 pubmed publisher
    The results from the published studies on the relationship between GSTM1/GSTT1 null genotypes and renal cell carcinoma (RCC) risk are still conflicting...
  14. Lima C, Ortega M, Marson F, Zulli R, Ribeiro A, Bertuzzo C. Cystic fibrosis transmembrane conductance regulator gene mutations and glutathione S-transferase null genotypes in cystic fibrosis patients in Brazil. J Bras Pneumol. 2012;38:50-6 pubmed
    ..regulator (CFTR) gene and deletion of the glutathione S-transferase (GST) genes mu-1 (GSTM1) and theta-1 (GSTT1) have on the clinical course of cystic fibrosis (CF) in patients residing in the southeastern region of Brazil...
  15. Rudolph A, Hein R, Hoffmeister M, Forsti A, Hemminki K, Risch A, et al. Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy. Int J Cancer. 2012;131:E841-8 pubmed publisher
    Copy number variations (CNVs) of the glutathione-S-transferase ?-1 (GSTT1) and glutathione-S-transferase ?-1 (GSTM1) gene loci can lead to complete lack of enzyme and have been associated with colorectal cancer (CRC) risk...
  16. Yu L, Wang C, Xi B, Sun L, Wang R, Yan Y, et al. GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population. World J Gastroenterol. 2011;17:3248-56 pubmed publisher
    To investigate the association between GSTM1 and GSTT1 polymorphisms and the risk of hepatocellular carcinoma (HCC) in Chinese population. Literature databases including PubMed, ISI web of science and other databases were searched...
  17. Ramprasath T, Senthil Murugan P, Prabakaran A, Gomathi P, Rathinavel A, Selvam G. Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes. Biochem Biophys Res Commun. 2011;407:49-53 pubmed publisher
    ..Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) are known for their broad range of detoxification and in the metabolism of xenobiotics...
  18. Hezova R, Bienertova Vasku J, Sachlova M, Brezkova V, Vasku A, Svoboda M, et al. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. Eur J Med Res. 2012;17:17 pubmed publisher
    ..study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European ..
  19. Yang X, Qiu M, Hu J, Wang X, Jiang F, Yin R, et al. GSTT1 null genotype contributes to lung cancer risk in asian populations: a meta-analysis of 23 studies. PLoS ONE. 2013;8:e62181 pubmed publisher
    ..Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results...
  20. Li C, Long J, Hu X, Zhou Y. GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. Eur J Clin Microbiol Infect Dis. 2013;32:859-68 pubmed publisher
    The results of studies investigating the associations between GSTM1 and GSTT1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ADIH) risk exhibit much controversy...
  21. Sharma A, Pandey A, Sardana S, Sehgal A, Sharma J. Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations. Asian Pac J Cancer Prev. 2012;13:5647-52 pubmed
    ..In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi...
  22. Piacentini S, Polimanti R, Moscatelli B, Re M, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. J Investig Allergol Clin Immunol. 2012;22:252-6 pubmed
    ..To investigate whether GSTM1, GSTT1, and GSTP1 polymorphisms are associated with asthma development...
  23. Economopoulos K, Choussein S, Vlahos N, Sergentanis T. GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis. Int J Gynecol Cancer. 2010;20:1576-80 pubmed publisher
    ..whether glutathione S-transferase (GST) polymorphisms (GST mu-1 [GSTM1] null/present genotype and GST theta-1 [GSTT1] null/present genotype) confer additional risk for cervical cancer...
  24. Zhou H, Feng X, Zheng B, Qian J, He W. A meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer including 31802 subjects. Mol Biol Rep. 2013;40:5713-21 pubmed publisher
    The relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer from the published reports are still conflicting...
  25. Berber U, Yilmaz I, Yilmaz O, Haholu A, Kucukodaci Z, Ates F, et al. CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms and bladder cancer risk in a Turkish population. Asian Pac J Cancer Prev. 2013;14:3925-9 pubmed
    ..reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study...
  26. Kumar V, Yadav C, Datta S, Singh S, Ahmed R, Goel S, et al. Association of GSTM1 and GSTT1 polymorphism with lipid peroxidation in benign prostate hyperplasia and prostate cancer: a pilot study. Dis Markers. 2011;30:163-9 pubmed publisher
    ..Based on genotyping, subjects were categorized into: GSTM1+/GSTT1+, GSTM1-/GSTT1+, GSTM1+/GSTT1- and GSTM1-/GSTT1-...
  27. Agrawal D, Gupta S, Agarwal D, Gupta O, Agarwal M. Role of GSTM1 and GSTT1 polymorphism: susceptibility to oral submucous fibrosis in the North Indian population. Oncology. 2010;79:181-6 pubmed publisher
    ..of GST variants with the risk of oral submucous fibrosis (OSF), the distribution of polymorphisms in GSTM1 and GSTT1 was studied in 90 OSF patients and 130 healthy controls. Genotypic analysis was performed by multiplex PCR...
  28. Safarinejad M, Shafiei N, Safarinejad S. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran. Prostate Cancer Prostatic Dis. 2011;14:105-13 pubmed publisher
    We evaluated the relationship between polymorphisms in the glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa)...
  29. Monteiro T, El Jaick K, Jeovanio Silva A, Brasil P, Costa M, Rolla V, et al. The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury. J Clin Pharm Ther. 2012;37:712-8 pubmed publisher
    ..Several studies have investigated the genetic null variants of GSTM1 and GSTT1 as possible risk factors for ATD-induced liver injury; however, those findings are inconsistent...
  30. Cilensek I, Mankoc S, Petrovic M, Petrovic D. GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against retinopathy. Dis Markers. 2012;32:93-9 pubmed publisher
    ..whether the genetic polymorphisms: polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of the GSTP1 are associated with DR in Slovenian patients with type 2 diabetes...
  31. Tang S, Lv X, Zhang Y, Wu S, Yang Z, Xia Y, et al. CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study. J Clin Pharm Ther. 2012;37:588-93 pubmed publisher
    ..We aimed to investigate possible associations of CYP2E1, GSTM1 and GSTT1 genetic polymorphisms with ATDH using a more robust case-control study nested in a population-based prospective ..
  32. Xu D, Yan S, Yin J, Zhang P. Null genotype of GSTT1 contributes to colorectal cancer risk in Asian populations: evidence from a meta-analysis. Asian Pac J Cancer Prev. 2011;12:2279-84 pubmed
    Studies of associations between genetic polymorphism of glutathione S-transferase T1(GSTT1) and risk of colorectal cancer (CRC) in Asian populations have reported controversial results...
  33. Xue H, Su J, Sun K, Xie W, Wang H. Glutathione S-transferase M1 and T1 gene polymorphism and COPD risk in smokers: an updated analysis. Mol Biol Rep. 2012;39:5033-42 pubmed publisher
    We evaluated the association between GSTM1 and GSTT1 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease (COPD) in smokers. A meta-analysis of the published case-control studies was performed...
  34. Chen X, Zhao R, Qiu L, Yuan H, Mao C, Hu X, et al. Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility. Cytokine. 2011;56:477-80 pubmed publisher
    The association between present/null polymorphism of glutathione S-transferase T1 (GSTT1) and breast cancer risk are still inconclusive. We performed a meta-analysis to derive a more precise estimation of the relationship...
  35. Gao L, Pan X, Li L, Liang W, Bai P, Rao L, et al. Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-based meta-analysis. PLoS ONE. 2011;6:e20157 pubmed publisher
    ..identified by searching PubMed, EMBASE, ISI Web of Science and CBM databases: 23 evaluated GSTM1 and 19 evaluated GSTT1. Crude odds ratios with corresponding 95% confidence intervals were used to estimate the association between GSTM1 ..
  36. Salinas Sanchez A, Sanchez Sanchez F, Donate Moreno M, Rubio Del Campo A, Serrano Oviedo L, Giménez Bachs J, et al. GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer. Urol Oncol. 2012;30:864-70 pubmed publisher
    To estimate the prevalence and importance of GSTT1, GSTM1, and CYP1B1 genotypes in renal cell carcinoma (RCC), and to identify their value as a prognostic factor...
  37. Yang P, Bamlet W, Ebbert J, Taylor W, de Andrade M. Glutathione pathway genes and lung cancer risk in young and old populations. Carcinogenesis. 2004;25:1935-44 pubmed
    ..Using PCR amplification of genomic DNA, polymorphic markers for gammaGCS, GPX1, GSTP1 (I105V and A114V), GSTM1 and GSTT1 were genotyped...
  38. Nakazato H, Suzuki K, Matsui H, Koike H, Okugi H, Ohtake N, et al. Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population. Anticancer Res. 2003;23:2897-902 pubmed
    ..The genetic polymorphisms of GSTM1, GSTT1 and GSTP1 genes have been studied to estimate the relative risk of various cancers...
  39. Dialyna I, Miyakis S, Georgatou N, Spandidos D. Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. Oncol Rep. 2003;10:1829-35 pubmed
    ..study, using PCR-RFLP based assays, we investigated the distribution of genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 genes in Greek lung cancer patients (N=122) and healthy controls (N=178)...
  40. Ko Y, Abel J, Harth V, Brode P, Antony C, Donat S, et al. Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res. 2001;61:4398-404 pubmed
    ..the effects that the genetic variants of the cytochrome (CYP)1A1, CYP1B1, glutathione-S-transferase (GST)M1, GSTT1, and GSTP1 genes have on modifying the risk of smoking-related HNSCC...
  41. Alexandrie A, Rannug A, Juronen E, Tasa G, Warholm M. Detection and characterization of a novel functional polymorphism in the GSTT1 gene. Pharmacogenetics. 2002;12:613-9 pubmed
    A novel functional polymorphism in the GSTT1 gene associated with the non-conjugator phenotype has been identified...
  42. Beer T, Evans A, Hough K, Lowe B, McWilliams J, Henner W. Polymorphisms of GSTP1 and related genes and prostate cancer risk. Prostate Cancer Prostatic Dis. 2002;5:22-7 pubmed
    ..Genotyping of the GSTP1 (Ile105Val), GSTM1 (null), GSTT1 (null) and CYP1A1 (Ile462Val) genes was performed using polymerase chain reaction (PCR) based techniques on DNA ..
  43. Abu Amero K, Al Boudari O, Mohamed G, Dzimiri N. T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. BMC Med Genet. 2006;7:38 pubmed
    The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial. In addition, no such investigation has previously been conducted among Arabs...
  44. Wang J, Jiang J, Zhao Y, Gajalakshmi V, Kuriki K, Suzuki S, et al. Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case-control study in an Indian population. Cancer Epidemiol. 2011;35:66-72 pubmed publisher
    ..55; 95% CI, 1.05-2.30), while the GSTT1 null genotype with a greater risk of colon cancer (OR=2.15; 95% CI, 1.04-4.32)...
  45. Feuillet Fieux M, Nguyen Khoa T, Loriot M, Kelly M, de Villartay P, Sermet I, et al. Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study. Clin Biochem. 2009;42:57-63 pubmed publisher
    ..GST activity and genotype could play an important role in modulating P. aeruginosa lung infection in CF patients. ..
  46. Leme C, Raposo L, Ruiz M, Biselli J, Galbiatti A, Maniglia J, et al. [GSTM1 and GSTT1 genes analysis in head and neck cancer patients]. Rev Assoc Med Bras (1992). 2010;56:299-303 pubmed
    ..profile and identify risk factors among patients with head and neck cancer and relate them to the polymorphism of GSTT1 and GSTM1...
  47. Rossi A, Hansteen I, Skjelbred C, Ballardin M, Maggini V, Murgia E, et al. Association between frequency of chromosomal aberrations and cancer risk is not influenced by genetic polymorphisms in GSTM1 and GSTT1. Environ Health Perspect. 2009;117:203-8 pubmed publisher
    ..To evaluate the role of polymorphisms in glutathione S-transferase (GST) M1 (GSTM1) and theta 1 (GSTT1) as effect modifiers of the association between CA and cancer risk...
  48. Sherratt P, Pulford D, Harrison D, Green T, Hayes J. Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in hu. Biochem J. 1997;326 ( Pt 3):837-46 pubmed
    ..Most significantly, GST T1-1 was found in only low levels in human pulmonary soluble extract of cells, suggesting that in man the lung has little capacity to activate the volatile dichloromethane. ..
  49. Kiyohara C, Yamamura K, Nakanishi Y, Takayama K, Hara N. Polymorphism in GSTM1, GSTT1, and GSTP1 and Susceptibility to Lung Cancer in a Japanese Population. Asian Pac J Cancer Prev. 2000;1:293-298 pubmed
    ..Three GST polymorphisms (GSTM1, GSTT1 and GSTP1) were determined among 86 male patients with lung carcinomas and 88 healthy male subjects...
  50. Lai R, Crevier L, Thabane L. Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2005;14:1784-90 pubmed
    ..Papers were included if they were observational studies investigating the influence of GSTM1, GSTT1, GSTP1 I105V, or GSTP1 A114V on the development of adult brain cancers...
  51. Salinas Souza C, Petrilli A, de Toledo S. Glutathione S-transferase polymorphisms in osteosarcoma patients. Pharmacogenet Genomics. 2010;20:507-15 pubmed publisher
    ..This study aims to investigate the genotype frequencies of GSTM1, GSTT1 and GSTM3 genes in 80 osteosarcoma patients and 160 normal control participants, and also the influence of these ..
  52. Sharma A, Sharma J, Murthy N, Mitra A. Polymorphisms at GSTM1 and GSTT1 gene loci and susceptibility to cervical cancer in Indian population. Neoplasma. 2004;51:12-6 pubmed
    ..A multiplex polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from cases with cervical cancer (n=142) and normal controls (n=96)...
  53. Moaven O, Raziee H, Sima H, Ganji A, Malekzadeh R, A rabi A, et al. Interactions between Glutathione-S-Transferase M1, T1 and P1 polymorphisms and smoking, and increased susceptibility to esophageal squamous cell carcinoma. Cancer Epidemiol. 2010;34:285-90 pubmed publisher
    ..Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 in association with some environmental factors and their impact on esophageal cancer susceptibility were ..
  54. Sharma A, Mishra A, Das B, Sardana S, Sharma J. Genetic polymorphism at GSTM1 and GSTT1 gene loci and susceptibility to oral cancer. Neoplasma. 2006;53:309-15 pubmed
    ..This study evaluates the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci on susceptibility to oral cancer...
  55. Lecomte T, Landi B, Beaune P, Laurent Puig P, Loriot M. Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy. Clin Cancer Res. 2006;12:3050-6 pubmed
    ..genetic variants for GSTP1 exon 5 (Ile105Val), GSTP1 exon 6 (Ala114Val), GSTM1 (homozygous deletion), and GSTT1 (homozygous deletion)...
  56. Schneider J, Bernges U, Philipp M, Woitowitz H. GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett. 2004;208:65-74 pubmed
    The impact of genetic polymorphisms in GSTM1, GSTP1 or GSTT1 on susceptibility to lung cancer has received particular interest since these enzymes play a central role in detoxification of major classes of tobacco carcinogens...
  57. Skuladottir H, Autrup H, Autrup J, Tjoenneland A, Overvad K, Ryberg D, et al. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. Lung Cancer. 2005;48:187-99 pubmed
    ..and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2...
  58. Silig Y, Pinarbasi H, Gunes S, Ayan S, Bagci H, Cetinkaya O. Polymorphisms of CYP1A1, GSTM1, GSTT1, and prostate cancer risk in Turkish population. Cancer Invest. 2006;24:41-5 pubmed
    ..association of the prostate cancer risk with genotype frequencies of the Phase I (CYP1A1) and Phase II (GSTM1 and GSTT1) biotransformation enzymes was investigated in 321 Turkish individuals (152 prostate cancer patients and 169 age-..
  59. Aydin Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias. Am J Hematol. 2006;81:162-70 pubmed
    ..The CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 polymorphisms in ALL (n = 156) and AML (n = 94) patients and 140 healthy controls were genotyped by PCR ..
  60. Sun C, Wang L, Chen C, Lu S, You S, Wang L, et al. Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. Carcinogenesis. 2001;22:1289-94 pubmed
    ..GSTM1 and GSTT1 genotypes were determined by PCR...
  61. Aban M, Ertunc D, Tok E, Tamer L, Arslan M, Dilek S. Modulating interaction of glutathione-S-transferase polymorphisms with smoking in endometriosis. J Reprod Med. 2007;52:715-21 pubmed
    ..We assessed the interaction of smoking and GSTM1 and GSTT1 polymorphisms in these patients...
  62. Bernardini S, Bellincampi L, Ballerini S, Federici G, Iori R, Trequattrini A, et al. Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele. Clin Chem. 2005;51:944-51 pubmed
    ..to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE genotypes to investigate their role as susceptibility genes for late-onset AD (LOAD)...
  63. Mir O, Alexandre J, Tran A, Durand J, Pons G, Treluyer J, et al. Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity. Ann Oncol. 2009;20:736-40 pubmed publisher
    ..The GSTM1 (null), GSTT1 (null) and GSTP1 (Ile(105)Val and Ala(114)Val) polymorphisms were determined in a cohort of cancer patients ..
  64. Deng Z, Wei Y, Ma Y. Polymorphism of glutathione S-transferase mu 1 and theta 1 genes and hepatocellular carcinoma in southern Guangxi, China. World J Gastroenterol. 2005;11:272-4 pubmed
    Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of a wide range of carcinogens, but deletions of the genes are commonly found in the population...
  65. Ha Y, Yan C, Lym M, Jeong P, Kim W, Kim Y, et al. GSTT1 as a prognosticator for recurrence and progression in patients with non-muscle-invasive bladder cancer. Dis Markers. 2010;29:81-7 pubmed publisher
    ..was to investigate the effect of homozygous glutathione S-transferase-? (GSTM1) and glutathione S-transferase-? (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC)...
  66. Harth V, Schafer M, Abel J, Maintz L, Neuhaus T, Besuden M, et al. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. J Toxicol Environ Health A. 2008;71:887-97 pubmed publisher
    ..We focused on the impact of 22 sequence variations in CYP1A1, CYP1B1, CYP2E1, ERCC2/XPD, GSTM1, GSTP1, GSTT1, NAT2, NQO1, and XRCC1...
  67. Losi Guembarovski R, Colus I, De Menezes R, Poliseli F, Chaves V, Kuasne H, et al. Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population. Anticancer Res. 2008;28:1023-8 pubmed
    ..control association study was carried out to investigate polymorphisms in genes CYP1A1 (3801T > C), GSTM1, and GSTT1 (null genotypes) and oral squamous cell carcinoma (OSCC), including a correlation with some histopathological ..
  68. Singh H, Sachan R, Devi S, Pandey S, Mittal B. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Am J Obstet Gynecol. 2008;198:303.e1-6 pubmed publisher
    The objective of the study was to evaluate the influence of genetic polymorphisms of GSTM1, GSTT1, and GSTM3 on the susceptibility of cervical cancer...
  69. Wideroff L, Vaughan T, Farin F, Gammon M, Risch H, Stanford J, et al. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Detect Prev. 2007;31:233-6 pubmed
    ..case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP1; GSTM1; GSTT1; NAT1; and CYP1A1. Histologically confirmed incident cases, ages 30-79, were identified in three US locations...
  70. Hatagima A, Costa E, Marques C, Koifman R, Boffetta P, Koifman S. Glutathione S-transferase polymorphisms and oral cancer: a case-control study in Rio de Janeiro, Brazil. Oral Oncol. 2008;44:200-7 pubmed
    This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro...
  71. Yang G, Gao Y, Shu X, Cai Q, Li G, Li H, et al. Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk. Am J Clin Nutr. 2010;91:704-11 pubmed publisher
    ..04) and the GSTT1-null (P for trend = 0.07) genotype groups...
  72. Palma S, Novelli F, Padua L, Venuti A, Prignano G, Mariani L, et al. Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk. J Cancer Res Clin Oncol. 2010;136:1101-9 pubmed publisher
    ..DNA was extracted from peripheral blood samples or cytobrush and individuals were genotyped for GSTM1, GSTT1, and GSTP1 polymorphisms using PCR and PCR/RFLP techniques...
  73. Mustafa M, Pathak R, Ahmed T, Ahmed R, Tripathi A, Guleria K, et al. Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor. Clin Biochem. 2010;43:1124-8 pubmed publisher
    ..The present study was designed to investigate association of GSTM1 and GSTT1 gene polymorphisms with PTL and their relationship with oxidative stress markers...
  74. Asim M, Khan L, Husain S, Husain S, Sarma M, Ahmad I, et al. Genetic polymorphism of glutathione S transferases M1 and T1 in Indian patients with hepatocellular carcinoma. Dis Markers. 2010;28:369-76 pubmed publisher