GSTP1

Summary

Gene Symbol: GSTP1
Description: glutathione S-transferase pi 1
Alias: DFN7, FAEES3, GST3, GSTP, HEL-S-22, glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III
Species: human
Products:     GSTP1

Top Publications

  1. Schneider J, Bernges U, Philipp M, Woitowitz H. GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett. 2004;208:65-74 pubmed
    The impact of genetic polymorphisms in GSTM1, GSTP1 or GSTT1 on susceptibility to lung cancer has received particular interest since these enzymes play a central role in detoxification of major classes of tobacco carcinogens...
  2. Epplein M, Wilkens L, Tiirikainen M, Dyba M, Chung F, Goodman M, et al. Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2009;18:314-20 pubmed publisher
    ..We measured prediagnositic urinary isothiocyanate levels adjusted for creatinine and analyzed GSTM1, GSTT1, and GSTP1 polymorphisms in 173 cases and 313 matched controls, with biospecimens collected between 2001 and 2006...
  3. Lu S, Wang Z, Cui D, Liu H, Hao X. Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res Treat. 2011;125:253-9 pubmed publisher
    Glutathione S-transferase P1 (GSTP1) is involved in a wide range of detoxifying reactions...
  4. Su M, Tsai C, Tung K, Hwang B, Liang P, Chiang B, et al. GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma. Allergy. 2013;68:1614-7 pubmed publisher
    ..Our results show a significant two-way gene-air pollution interaction between glutathione S-transferase P (GSTP1) and PM10 on the risk of childhood asthma...
  5. Masood N, Kayani M, Malik F, Mahjabeen I, Baig R, Faryal R. Genetic variation in carcinogen metabolizing genes associated with oral cancer in pakistani population. Asian Pac J Cancer Prev. 2011;12:491-5 pubmed
    ..Polymorphisms in the encoding genes (CYP1A1, GSTM1, GSTT1 and GSTP1) potentially may therefore contribute towards risk association for oral cancer...
  6. Schultz E, Devadason S, Khoo S, Zhang G, Bizzintino J, Martin A, et al. The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma. J Asthma. 2010;47:1049-56 pubmed publisher
    ..To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity...
  7. Bao L, Niu J, Song H, Wang Y, Ma R, Ren X, et al. Association between the GSTP1 codon 105 polymorphism and gastric cancer risk: an updated meta-analysis. Asian Pac J Cancer Prev. 2012;13:3687-93 pubmed
    ..was performed to address a more accurate estimation of the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and risk of gastric cancer (GC), which has been widely reported with conflicting results...
  8. Gönül N, Kadioglu E, Kocabas N, Ozkaya M, Karakaya A, Karahalil B. The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: a case-control study in a Turkish population. Gene. 2012;505:121-7 pubmed publisher
    The aim of the present study was to investigate the role of some polymorphisms in GSTs (GSTM1, GSTT1 and GSTP1) which are very important protective mechanisms against oxidative stress and in OGG1 gene which is important in DNA repair, ..
  9. Sau A, Filomeni G, Pezzola S, D Aguanno S, Tregno F, Urbani A, et al. Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. Mol Biosyst. 2012;8:994-1006 pubmed publisher
    The effect of the glutathione transferase P1-1 (GSTP1-1) targeting has been investigated in both sensitive (U-2OS) and cisplatin-resistant (U-2OS/CDDP4 ?g) human osteosarcoma cell lines...

More Information

Publications73

  1. Sameer A, Qadri Q, Siddiqi M. GSTP1 I105V polymorphism and susceptibility to colorectal cancer in Kashmiri population. DNA Cell Biol. 2012;31:74-9 pubmed publisher
    The glutathione S-transferase (GST) enzyme encoded by the GSTP1 gene is one of the critical enzymes involved in detoxification of carcinogens...
  2. Koh W, Nelson H, Yuan J, Van Den Berg D, Jin A, Wang R, et al. Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore. Carcinogenesis. 2011;32:1507-11 pubmed publisher
    ..We determined the deletion polymorphisms of GSTM1 and GSTT1 and the functional polymorphism at codon 105 of GSTP1 for each subject...
  3. Economopoulos K, Sergentanis T, Vlahos N. Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis. Int J Gynecol Cancer. 2010;20:732-7 pubmed publisher
    ..studies have examined whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, and GSTP1 Ile105Val) represent risk factors for ovarian cancer, as they all may denote reduced enzyme activity...
  4. Hlavata I, Vrana D, Smerhovsky Z, Pardini B, Naccarati A, Vodicka P, et al. Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. Oncol Rep. 2010;24:1347-53 pubmed
    ..These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis. ..
  5. Wang G, Hou J, Ma L, Xie J, Yin J, Xu D, et al. Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. Cancer Epidemiol. 2012;36:177-82 pubmed publisher
    ..of cytochrome P450 mono-oxygenase (CYP1A1: 6235T>C, 4889A>G, and 4887C>A), glutathione S-transferase (GSTP1: 342A>G), and N-acetyltransferase (NAT2: 481C>T, 590G>A, and 857G>A) were identified by PCR-RFLP and ..
  6. Ahmad S, Arjumand W, Seth A, Kumar Saini A, Sultana S. Impact of glutathione transferase M1, T1, and P1 gene polymorphisms in the genetic susceptibility of North Indian population to renal cell carcinoma. DNA Cell Biol. 2012;31:636-43 pubmed publisher
    In this study, we investigated the association of GSTP1, GSTM1, and GSTP1 genetic variants with renal cell carcinoma (RCC) among North Indian patients...
  7. Wlodarczyk M, Nowicka G. Common polymorphisms in CYP1A1, GSTM1, GSTT1, GSTP1 and XPD genes and endogenous DNA damage. Mol Biol Rep. 2012;39:5699-704 pubmed publisher
    ..to polymorphisms in genes encoding phase I detoxifying enzyme-CYP1A1, phase II detoxifying enzymes-GSTM1, GSTT1, GSTP1 and enzyme involved in nucleotide excision repair-XPD...
  8. Feng X, Zheng B, Shi J, Qian J, He W, Zhou H. Association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer. Mol Biol Rep. 2012;39:10313-23 pubmed publisher
    The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present...
  9. Wei B, Zhou Y, Xu Z, Ruan J, Cheng H, Zhu M, et al. GSTP1 Ile105Val polymorphism and prostate cancer risk: evidence from a meta-analysis. PLoS ONE. 2013;8:e71640 pubmed publisher
    Glutathione S-transferase P1 (GSTP1) is thought to be involved in the detoxification of reactive carcinogen metabolites...
  10. De Luca A, Mei G, Rosato N, Nicolai E, Federici L, Palumbo C, et al. The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex. Cell Death Dis. 2014;5:e1015 pubmed publisher
    We provide the first biochemical evidence of a direct interaction between the glutathione transferase P1-1 (GSTP1-1) and the TRAF domain of TNF receptor-associated factor 2 (TRAF2), and describe how ligand binding modulates such an ..
  11. Wu T, Giovannucci E, Welge J, Mallick P, Tang W, Ho S. Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis. Br J Cancer. 2011;105:65-73 pubmed publisher
    ..Prostate-specific antigen (PSA) screening has low specificity. Assessment of methylation status in body fluids may complement PSA screening if the test has high specificity...
  12. Luscombe C, French M, Liu S, Saxby M, Farrell W, Jones P, et al. Glutathione S-transferase GSTP1 genotypes are associated with response to androgen ablation therapy in advanced prostate cancer. Cancer Detect Prev. 2002;26:376-80 pubmed
    We determined whether the glutathione S-transferase GSTP1 Ile105 --> Val105 substitution is associated with response to androgen ablation therapy in patients with advanced prostate cancer...
  13. Tan K, Jankova L, Chan C, Fung C, Clarke C, Lin B, et al. Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer. Histopathology. 2011;59:1057-70 pubmed publisher
    ..Further appropriately designed studies should aim to discover whether GST Pi can predict response to adjuvant chemotherapy. ..
  14. Singh S, Kumar V, Singh P, Thakur S, Banerjee B, Rautela R, et al. Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides. Mutat Res. 2011;725:36-42 pubmed publisher
    ..study was designed to determine the genotoxic effects using DNA damage and its association with GSTM1, GSTT1, and GSTP1 (Ile105Val) genetic polymorphisms in workers occupationally exposed to organophosphate pesticides (OPs)...
  15. Fiolka R, Zubor P, Janusicova V, Visnovsky J, Mendelova A, Kajo K, et al. Promoter hypermethylation of the tumor-suppressor genes RASSF1A, GSTP1 and CDH1 in endometrial cancer. Oncol Rep. 2013;30:2878-86 pubmed publisher
    ..In the present study, we examined the methylation status of the GSTP1, CDH1 and RASSF1A genes in endometrioid endometrial cancer (EEC), endometrial complex hyperplasia (EHP) and ..
  16. Li D, Dandara C, Parker M. The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genet. 2010;11:47 pubmed publisher
    ..The GSTP1 341T variant was associated with significantly increased risk of developing OSCC as observed from the odds ratios ..
  17. Soucek P, Susova S, Mohelnikova Duchonova B, Gromadzinska J, Moraviec Sztandera A, Vodicka P, et al. Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe. Neoplasma. 2010;57:415-21 pubmed
    ..polymorphisms in enzymes metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT1, ADH1B and ADH1C)...
  18. Wang J, Jiang J, Zhao Y, Gajalakshmi V, Kuriki K, Suzuki S, et al. Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case-control study in an Indian population. Cancer Epidemiol. 2011;35:66-72 pubmed publisher
    ..80; 95% CI, 0.94-35.91) cancer risk was shown for the combination of GSTM1 null, GSTT1 null and GSTP1 105Val allele...
  19. Yu Z, Li Z, Cai B, Wang Z, Gan W, Chen H, et al. Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis. Tumour Biol. 2013;34:1855-63 pubmed publisher
    Many studies have reported the role of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with prostate cancer (PCa) risk. However, these studies have yielded conflicting results...
  20. Gong M, Dong W, Shi Z, Xu Y, Ni W, An R. Genetic polymorphisms of GSTM1, GSTT1, and GSTP1 with prostate cancer risk: a meta-analysis of 57 studies. PLoS ONE. 2012;7:e50587 pubmed publisher
    The GSTM1, GSTT1 and GSTP1 polymorphisms might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers...
  21. Bid H, Konwar R, Saxena M, Chaudhari P, Agrawal C, Banerjee M. Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population. J Postgrad Med. 2010;56:176-81 pubmed publisher
    ..Analysis of GSTM1 and GSTT1 gene polymorphisms was performed by multiplex polymerase chain reaction (PCR) and GSTP1 by PCR-Restriction Fragment Length Polymorphism (RFLP)...
  22. Ramprasath T, Senthil Murugan P, Prabakaran A, Gomathi P, Rathinavel A, Selvam G. Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes. Biochem Biophys Res Commun. 2011;407:49-53 pubmed publisher
    ..Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) are known for their broad range of detoxification and in the metabolism of xenobiotics...
  23. Yao S, Barlow W, Albain K, Choi J, Zhao H, Livingston R, et al. Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res. 2010;16:6169-76 pubmed publisher
    ..treated group and hazard ratios for DFS associated with selected functional polymorphisms in CYP2B6CYP3A4GSTA1 and GSTP1 were estimated by logistic regression and Cox proportional hazard regression...
  24. Lang J, Song X, Cheng J, Zhao S, Fan J. Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case-control studies. PLoS ONE. 2012;7:e48132 pubmed publisher
    The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent...
  25. Zhou F, Yu Z, Jiang T, Lv H, Yao R, Liang J. Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Swiss Med Wkly. 2011;141:w13275 pubmed publisher
    Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical ..
  26. Vural B, Yakar F, Derin D, Saip P, Yakar A, Demirkan A, et al. Evaluation of glutathione S-transferase P1 polymorphisms (Ile105Val and Ala114Val) in patients with small cell lung cancer. Genet Test Mol Biomarkers. 2012;16:701-6 pubmed publisher
    Glutathione S-transferase P1 (GSTP1) plays an important role in cellular protection against oxidative stress and toxic chemicals...
  27. Matuschek C, Bölke E, Lammering G, Gerber P, Peiper M, Budach W, et al. Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease. Eur J Med Res. 2010;15:277-86 pubmed
    ..domain family protein 1A (RASSF1A), estrogen receptor 1 (ESR1), CDKN2A (p16) and glutathione s-transferase pi 1 (GSTP1). Beta actin (ACTB) served as control...
  28. Wu K, Wang X, Xie Z, Liu Z, Lu Y. Glutathione S-transferase P1 gene polymorphism and bladder cancer susceptibility: an updated analysis. Mol Biol Rep. 2013;40:687-95 pubmed publisher
    Studies investigating the association between glutathione S-transferase P1 (GSTP1) gene polymorphism and bladder cancer (BC) risk have reported conflicting results...
  29. Trock B, Brotzman M, Mangold L, Bigley J, Epstein J, McLeod D, et al. Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies. BJU Int. 2012;110:56-62 pubmed publisher
    ..known on the subject? and What does the study add? Hypermethylation of genes such as glutathione-S-transferase P1 (GSTP1) and adenomatous polyposis coli (APC) occurs with high frequency in prostate tumour tissue but is much less common ..
  30. De Luca A, Federici L, De Canio M, Stella L, Caccuri A. New insights into the mechanism of JNK1 inhibition by glutathione transferase P1-1. Biochemistry. 2012;51:7304-12 pubmed publisher
    The role played by glutathione transferase P1-1 (GSTP1-1) in modulating the c-Jun N-terminal kinase (JNK) pathway has been extensively investigated using JNK isoforms known to exert opposite effects in the cells...
  31. Zhao Y, Wang F, Shan S, Zhao Y, Qiu X, Li X, et al. Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - a meta-analysis. Int J Med Sci. 2010;7:300-8 pubmed
    A number of studies have evaluated two functional polymorphisms on p53 Arg72Pro and GSTP1 Ile105Val, in relation to esophageal cancer susceptibility. However, the results remain conflicting rather than conclusive...
  32. Qadri Q, Sameer A, Shah Z, Hamid A, Alam S, Manzoor S, et al. Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population. Genet Mol Res. 2011;10:3038-45 pubmed publisher
    Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway...
  33. Hezova R, Bienertova Vasku J, Sachlova M, Brezkova V, Vasku A, Svoboda M, et al. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. Eur J Med Res. 2012;17:17 pubmed publisher
    ..associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population...
  34. Safarinejad M, Shafiei N, Safarinejad S. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran. Prostate Cancer Prostatic Dis. 2011;14:105-13 pubmed publisher
    We evaluated the relationship between polymorphisms in the glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa)...
  35. Reszka E, Jabłonowski Z, Wieczorek E, Gromadzinska J, Sosnowski M, Wasowicz W. GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism. Clin Biochem. 2011;44:1153-1155 pubmed publisher
    We explored association between GSTP1 Ile(105)Val (rs1695) polymorphism and GSTP1 mRNA expression in circulating blood leukocytes...
  36. Yadav D, Devi T, Ihsan R, Mishra A, Kaushal M, Chauhan P, et al. Polymorphisms of glutathione-S-transferase genes and the risk of aerodigestive tract cancers in the Northeast Indian population. Genet Test Mol Biomarkers. 2010;14:715-23 pubmed publisher
    ..The variant genotypes of GSTP1 were not associated with any of the aerodigestive tract cancers...
  37. Zhang B, Sun T, Zhang B, Zheng S, Lu N, Xu B, et al. Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer. Chin Med J (Engl). 2011;124:199-204 pubmed
    ..The aim of this research was to examine the effects of genetic polymorphisms in CYP3A, GSTP1 and MDR1 genes on treatment response and side-effects of breast cancer patients receiving EPI/CTX chemotherapy...
  38. Karen Ng L, Marhazlinda J, Rahman Z, Yang Y, Jalil N, Cheong S, et al. Combined effects of isothiocyanate intake, glutathione S-transferase polymorphisms and risk habits for age of oral squamous cell carcinoma development. Asian Pac J Cancer Prev. 2011;12:1161-6 pubmed
    ..Peripheral blood lymphocytes were obtained for genotyping of GSTM1, GSTT1 and GSTP1 using PCR multiplex and PCR-RFLP...
  39. Sailaja K, Surekha D, Rao D, Rao D, Vishnupriya S. Association of the GSTP1 gene (Ile105Val) polymorphism with chronic myeloid leukemia. Asian Pac J Cancer Prev. 2010;11:461-4 pubmed
    The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons...
  40. Matic M, Pekmezovic T, Djukic T, Mimic Oka J, Dragicevic D, Krivic B, et al. GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study. Urol Oncol. 2013;31:1184-92 pubmed publisher
    ..Genes encoding for GSTA1, GSTM1, GSTP1, and GSTT1 proteins are polymorphic, which can result in complete or partial loss of enzyme activity...
  41. Zhou L, Zhu Y, Zhang X, Li Y, Liu Z. Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study. Asian Pac J Cancer Prev. 2013;14:3861-4 pubmed
    ..We here aimed to investigate the relationships between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of AML...
  42. Pongtheerat T, Pakdeethai S, Purisa W, Chariyalertsak S, Petmitr S. Promoter methylation and genetic polymorphism of glutathione S-transferase P1 gene (GSTP1) in Thai breast- cancer patients. Asian Pac J Cancer Prev. 2011;12:2731-4 pubmed
    The GSTP1 gene encodes for a detoxification enzyme involved in protecting cells from carcinogens...
  43. Ada A, Kunak S, Hancer F, Soydas E, Alpar S, Gulhan M, et al. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population. Mol Biol Rep. 2012;39:5985-93 pubmed publisher
    ..In this study, we investigated the role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer and histological subtypes in 213 lung cancer patients ..
  44. Muñoz B, Magaña J, Romero Toledo I, Juárez Pérez E, López Moya A, Leyva García N, et al. The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico. Environ Toxicol Pharmacol. 2012;33:226-32 pubmed publisher
    ..of children from Coahuila state in Northern Mexico and to determine whether polymorphisms of the CYP1A1, GSTP1, and IL13 genes are associated with exposure to ETS and subsequently a higher risk for asthma...
  45. Yuille M, Condie A, Hudson C, Kote Jarai Z, Stone E, Eeles R, et al. Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Blood. 2002;99:4216-8 pubmed
    ..GSTM1, GSTT1, and GSTP1 genotypes were determined in 138 patients and 280 healthy individuals...
  46. Safronova O, Vavilin V, Lyapunova A, Makarova S, Lyakhovich V, Kaznacheeva L, et al. Relationship between glutathione S-transferase P1 polymorphism and bronchial asthma and atopic dermatitis. Bull Exp Biol Med. 2003;136:73-5 pubmed
    We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control)...
  47. He J, Connett J, Anthonisen N, Pare P, Sandford A. Glutathione S-transferase variants and their interaction with smoking on lung function. Am J Respir Crit Care Med. 2004;170:388-94 pubmed
    ..8 +/- 0.1) lung function at the beginning of the Lung Health Study. Homozygosity for GSTP1 105Val was significantly more frequent in the low- than in the high-function group (13.2 vs. 9.3%) (odds ratio = 1...
  48. Yokomizo A, Yamamoto K, Kinukawa N, Tsunoda T, Koga H, Naito S. Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy. Int J Urol. 2007;14:500-4 pubmed
    Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin...
  49. Zhang Y, Qu X, Jing W, Hu X, Yang X, Hou K, et al. GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling. Anticancer Drugs. 2009;20:208-14 pubmed publisher
    ..Glutathione S-transferase-pi (GSTP1) belongs to a supergene family of detoxifying enzymes involved in the prevention of DNA damage and subsequent ..
  50. Palmer C, Doney A, Lee S, Murrie I, Ismail T, Macgregor D, et al. Glutathione S-transferase M1 and P1 genotype, passive smoking, and peak expiratory flow in asthma. Pediatrics. 2006;118:710-6 pubmed
    ..The environmental tobacco smoke effect in GSTM1-null children with asthma could be cumulative over time, resulting in detrimental effects on peak expiratory flow rate in 13- to 21-year-olds with asthma. ..
  51. Jones B, Christensen A, Wise J, Yu H. Glutathione S-transferase polymorphisms and survival in African-American and white colorectal cancer patients. Cancer Epidemiol. 2009;33:249-56 pubmed publisher
    ..retrieved from hospital of diagnosis and assayed using multiplex PCR (GSTM1 and GSTT1) and PCR and RFLP analysis (GSTP1). Cox proportional hazards models provided adjusted hazard ratios (HR) and 95% confidence intervals (CI)...
  52. Niu D, Zhang J, Ren Y, Feng H, Chen W. HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells. Mol Oncol. 2009;3:67-76 pubmed publisher
    ..One of such tumor suppressor genes, GSTP1, shows reduced expression in many human cancers...
  53. Gaspar J, Rodrigues S, Gil O, Manita I, Ferreira T, Limbert E, et al. Combined effects of glutathione S-transferase polymorphisms and thyroid cancer risk. Cancer Genet Cytogenet. 2004;151:60-7 pubmed
    ..we conducted a case control study to evaluate the role of the GSTM1- and GSTT1-null genotypes and GSTP1 polymorphisms in thyroid cancer...
  54. Ali Osman F, Akande O, Antoun G, Mao J, Buolamwini J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem. 1997;272:10004-12 pubmed
  55. Zarate R, González Santigo S, de la Haba J, Bandres E, Morales R, Salgado J, et al. GSTP1 and MTHFR polymorphisms are related with toxicity in breast cancer adjuvant anthracycline-based treatment. Curr Drug Metab. 2007;8:481-6 pubmed
    ..b>GSTP1 polymorphism was linked to haematological GIII-IV toxicity (P = 0.044, HR= 6.4, 95% CI = 1.05 to 39...
  56. Kellen E, Hemelt M, Broberg K, Golka K, Kristensen V, Hung R, et al. Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review. Am J Epidemiol. 2007;165:1221-30 pubmed
    The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility...
  57. Li Y, Gauderman W, Avol E, Dubeau L, Gilliland F. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med. 2006;173:970-6 pubmed
    ..asthma may vary by ozone exposure and variants of oxidant defense genes glutathione-S-transferase (GST) M1 and GSTP1. To investigate the association of TNF G-308A with asthma and wheezing and to determine whether these associations ..
  58. Wideroff L, Vaughan T, Farin F, Gammon M, Risch H, Stanford J, et al. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Detect Prev. 2007;31:233-6 pubmed
    ..In a population-based case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP1; GSTM1; GSTT1; NAT1; and CYP1A1...
  59. Ruwali M, Pant M, Shah P, Mishra B, Parmar D. Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome. Mutat Res. 2009;669:36-41 pubmed publisher
    ..of functionally important polymorphism in cytochrome P450 2A6 (CYP2A6) and glutathione S-transferase P1 (GSTP1) genes with head and neck squamous cell carcinoma (HNSCC) and treatment response in cases receiving a combination ..
  60. Skuladottir H, Autrup H, Autrup J, Tjoenneland A, Overvad K, Ryberg D, et al. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. Lung Cancer. 2005;48:187-99 pubmed
    ..demographic and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2...
  61. Chandra R, Bentz B, Haines G, Robinson A, Radosevich J. Expression of glutathione s-transferase pi in benign mucosa, Barrett's metaplasia, and adenocarcinoma of the esophagus. Head Neck. 2002;24:575-81 pubmed
    ..GSTpi may protect the tumor cells themselves from the cytotoxic effects of free radicals. The biochemical role of GSTpi expression in malignant transformation deserves further investigation. ..
  62. Gebhardt G, Peters W, Hillermann R, Odendaal H, Carelse Tofa K, Raijmakers M, et al. Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa. J Obstet Gynaecol. 2004;24:866-72 pubmed
    ..and control mother - infant pairs with uncomplicated pregnancy outcome (n = 45) were analysed for the EPHX and GSTP1 polymorphisms by polymerase chain reaction amplification and restriction enzyme digestion...
  63. Cao W, Cai L, Rao J, Pantuck A, Lu M, Dalbagni G, et al. Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer. 2005;104:2400-8 pubmed
    ..b>GSTP1 may play a role in detoxification of tobacco-related carcinogens...
  64. Mir O, Alexandre J, Tran A, Durand J, Pons G, Treluyer J, et al. Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity. Ann Oncol. 2009;20:736-40 pubmed publisher
    ..The GSTM1 (null), GSTT1 (null) and GSTP1 (Ile(105)Val and Ala(114)Val) polymorphisms were determined in a cohort of cancer patients treated with docetaxel ..