Gene Symbol: GSTM3
Description: glutathione S-transferase mu 3
Alias: GST5, GSTB, GSTM3-3, GTM3, glutathione S-transferase Mu 3, GST class-mu 3, S-(hydroxyalkyl)glutathione lyase M3, brain GST, brain type mu-glutathione S-transferase, glutathione S-alkyltransferase M3, glutathione S-aralkyltransferase M3, glutathione S-aryltransferase M3, glutathione S-transferase M3 (brain), glutathione S-transferase mu 3 (brain), glutathione S-transferase, Mu-3, hGSTM3-3
Species: human
Products:     GSTM3

Top Publications

  1. Wikman H, Piirilä P, Rosenberg C, Luukkonen R, Kääriä K, Nordman H, et al. N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Pharmacogenetics. 2002;12:227-33 pubmed
    ..of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes...
  2. Sørensen M, Autrup H, Tjønneland A, Overvad K, Raaschou Nielsen O. Glutathione S-transferase T1 null-genotype is associated with an increased risk of lung cancer. Int J Cancer. 2004;110:219-24 pubmed
    ..nucleotide polymorphisms (SNPs) in GSTP1 (Ile105Val and Ala114Val) and a 3 base pair deletion polymorphism in GSTM3. We further investigated the effects of the GST polymorphisms on lung cancer risk within subgroups of subjects ..
  3. Liu X, Campbell M, Pittman G, Faulkner E, Watson M, Bell D. Expression-based discovery of variation in the human glutathione S-transferase M3 promoter and functional analysis in a glioma cell line using allele-specific chromatin immunoprecipitation. Cancer Res. 2005;65:99-104 pubmed
    ..used a gene expression screening approach to identify a functional regulatory SNP in glutathione S-transferase M3 (GSTM3). Anttila et al...
  4. Majumder M, Sikdar N, Paul R, Roy B. Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). Cancer Epidemiol Biomarkers Prev. 2005;14:2106-12 pubmed
    ..3-3.9) and cancer (OR, 1.9; 95% CI, 1.2-3.1). In a previous study on this population, it was shown that the GSTM3 (A/A) genotype increased the risk of oral leukoplakia and cancer among smokers, which has also been substantiated ..
  5. Holley S, Rajagopal R, Hoban P, Deakin M, Fawole A, Elder J, et al. Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. Int J Oncol. 2006;28:231-6 pubmed
    ..In this retrospective cohort, we have investigated associations between common GSTM1, GSTM3 and GSTP1 polymorphisms with factors known to influence clinical out-come and patient survival in colorectal ..
  6. Pandey S, Jain M, Nigam P, Choudhuri G, Mittal B. Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India. Biomarkers. 2006;11:250-61 pubmed
    ..risk of gallbladder cancer, the distribution of polymorphisms in the GST family of genes (GSTT1, GSTM1, GSTP1, and GSTM3) were studied in 106 cancer patients and 201 healthy controls...
  7. Jain M, Kumar S, Lal P, Tiwari A, Ghoshal U, Mittal B. Role of GSTM3 polymorphism in the risk of developing esophageal cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:178-81 pubmed
    b>GSTM3 is involved in detoxification of carcinogens and may be important in modulating cancer susceptibility...
  8. Yu K, Fan L, Di G, Yuan W, Zheng Y, Huang W, et al. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. Breast Cancer Res Treat. 2010;121:485-96 pubmed publisher
    ..In the GSTM1-/- group, the allele frequency of one SNP in GSTM3 was significantly different between cases and controls (P = 2.0 x 10(-4), corrected P = 0...
  9. Chatzimichalis M, Xenellis J, Tzagaroulakis A, Sarof P, Banis K, Gazouli M, et al. GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. J Laryngol Otol. 2010;124:318-23 pubmed publisher
    ..Frequencies of the genotypes GSTT1, GSTM1, GSTM3 and NAT2 were evaluated by polymerase chain reaction restriction fragment polymorphism...

More Information

Publications128 found, 100 shown here

  1. Loktionov A, Watson M, Gunter M, Stebbings W, Speakman C, Bingham S. Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. Carcinogenesis. 2001;22:1053-60 pubmed
    ..and smoking were slightly higher in the cancer group as a whole for GSTM1-null (*0/*0), GSTT1-null (*0/*0) and GSTM3 *A/*B or *B/*B when compared with the control group, but the differences did not reach statistical significance...
  2. Risch A, Wikman H, Thiel S, Schmezer P, Edler L, Drings P, et al. Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas. Pharmacogenetics. 2001;11:757-64 pubmed
    ..carcinomas (SCCs), and 353 hospital control subjects without malignant disease, genotype frequencies for GSTM1, GSTM3, GSTP1 and GSTT1 were determined by polymerase chain reaction (PCR)/ restriction fragment length polymorphism (..
  3. Buch S, Notani P, Bhisey R. Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population. Carcinogenesis. 2002;23:803-7 pubmed
    This study evaluates the influence of genetic polymorphism at GSTM1, GSTM3 and GSTT1 gene loci on oral cancer risk among Indians habituated to the use of, smokeless tobacco, bidi or cigarette...
  4. To Figueras J, Gené M, Gomez Catalan J, Piqué E, Borrego N, Caballero M, et al. Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. Cancer Lett. 2002;187:95-101 pubmed
    ..hydrolase gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer (N=204) and in a group of healthy controls ..
  5. Matthias C, Jahnke V, Fryer A, Strange R. [First results on the influence of polymorphisms at glutathione S-transferase, cytochrome P450, and tumor necrosis factor gene loci on the development of multiple head and neck cancer]. Laryngorhinootologie. 2003;82:25-30 pubmed
    ..Accordingly, we have examined genotype frequencies at GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1, CYP2E1, and TNF loci, in patients with single and multiple squamous cell carcinoma (SCC) ..
  6. Sikdar N, Paul R, Roy B. Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. Int J Cancer. 2004;109:95-101 pubmed
    ..consisting of 109 leukoplakia and 256 oral cancer patients and 259 controls, genotype frequencies at GSTM1, GSTT1, GSTM3 and GSTP1 loci were determined by polymerase chain reaction-restriction fragment length polymorphism methods and ..
  7. Rydzanicz M, Wierzbicka M, Gajecka M, Szyfter W, Szyfter K. The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck. Cancer Lett. 2005;224:263-78 pubmed
    ..polymorphisms of genes involved in carcinogen metabolic activation (CYP1A1, CYP2E1), detoxication (GSTM1, GSTT1, GSTM3, NAT2,) and DNA repair (XPD /A35931C-exon 23 and C22541A-exon 6/, XRCC1 /G28152A-exon 10 and C26304T-exon 6/, ..
  8. Marques C, Koifman S, Koifman R, Boffetta P, Brennan P, Hatagima A. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol. 2006;42:632-7 pubmed
    ..CYP1A1, CYP2E1, GSTM3, and NAT2 polymorphisms were determined in peripheral blood DNA of 231 oral cancer patients and 212 hospital ..
  9. Schwartzbaum J, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, et al. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2007;16:559-65 pubmed
    ..transferases (GST) detoxify environmental and endogenous compounds and levels of two polymorphic GST proteins, GSTM3 and GSTP1, are high in the brain...
  10. Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma V, Benhamou S, et al. Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer. Cancer Epidemiol Biomarkers Prev. 2001;10:229-36 pubmed
    ..Although only a moderate risk of breast cancer was seen for premenopausal women concurrently carrying the GSTM3*B allele containing genotypes and the GSTP1 Ile/ Ile genotype (OR, 2.07; 95% CI, 1.02-4...
  11. De Palma G, Dick F, Calzetti S, Scott N, Prescott G, Osborne A, et al. A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions. Mov Disord. 2010;25:912-9 pubmed publisher
    ..of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were ..
  12. Lv F, Zhou J, Zeng L, Xing D. β-cyclocitral upregulates salicylic acid signalling to enhance excess light acclimation in Arabidopsis. J Exp Bot. 2015;66:4719-32 pubmed publisher SA accumulation and NPR1 induced subsequent transcriptional reprogramming of gluthathione-S-transferase 5 (GST5) and GST13 implicated in detoxification...
  13. Stavrinou P, Mavrogiorgou M, Polyzoidis K, Kreft Kerekes V, Timmer M, Marselos M, et al. Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors. PLoS ONE. 2015;10:e0143285 pubmed publisher
    ..profile of seven phase I and II drug metabolizing genes (CYP1A1, CYP1B1, ALDH3A1, AOX1, GSTP1, GSTT1 and GSTM3) and some of their proteins...
  14. Teixeira D, Vargens D, Principe A, Oliveira E, Amorim A, Prata M, et al. High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations. Braz J Med Biol Res. 2010;43:677-80 pubmed
    A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk...
  15. Kanaujiya J, Lochab S, Kapoor I, Pal P, Datta D, Bhatt M, et al. Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells. Proteomics. 2013;13:2100-12 pubmed publisher
    ..In nutshell, these data indicate that MS-based proteomics approach identifies a novel ER? interacting protein Profilin1 that serves as a putative corepressor of ER? functions. ..
  16. Qu K, Liu S, Wang Z, Huang Z, Liu S, Chang H, et al. Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. World J Gastroenterol. 2015;21:4310-22 pubmed publisher
    ..Twelve tagging SNPs in GST genes (including GSTA1, GSTA4, GSTM2, GSTM3, GSTO1, GSTO2 and GSTP1) were genotyped using Sequenom MassARRAY iPLEX genotyping method in a cohort of 214 ..
  17. Zhang X, Shi Z, Lyv J, He X, Englert N, Zhang S. Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. Toxicol Sci. 2015;147:436-45 pubmed publisher that pyrene induced the expression of mouse liver metabolism enzymes including CYP2B10, CYP3A11, GSTm1, GSTm3, and SULT1A1, and caused hepatic glutathione depletion in wild-type but not CAR null mice...
  18. Martínez Treviño D, Moreno Treviño M, Salinas Santander M, Wohn L, Herrera González S, Aguirre Garza M, et al. Rapid Detection of the GSTM3 A/B Polymorphism Using Real-time PCR with TaqMan(®) Probes. Arch Med Res. 2016;47:142-5 pubmed publisher
    ..The GSTM3 gene is part of the GSTs gene family, and its polymorphism A/B has been associated with risk and protective ..
  19. Fryer A, Ramsay H, Lovatt T, Jones P, Hawley C, Nicol D, et al. Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis. 2005;26:185-91 pubmed
    ..In this study, we examined allelism in GSTM1, GSTM3, GSTT1 and GSTP1 in 361 Queensland renal transplant recipients...
  20. Cuna A, Halloran B, Faye Petersen O, Kelly D, Crossman D, Cui X, et al. Alterations in gene expression and DNA methylation during murine and human lung alveolar septation. Am J Respir Cell Mol Biol. 2015;53:60-73 pubmed publisher
    ..Genes of interest included those involved with detoxifying enzymes (Gstm3) and transforming growth factor-β signaling (bone morphogenetic protein 7 [Bmp7])...
  21. Chrysostomou C, Quandt E, Marshall N, Stone E, Georgiou G. An alternate pathway of arsenate resistance in E. coli mediated by the glutathione S-transferase GstB. ACS Chem Biol. 2015;10:875-82 pubmed publisher
    ..coli ΔarsC). We found that overexpression of glutathione S-transferase B (GstB) complemented the ΔarsC allele and conferred growth on media containing up to 5 mM sodium arsenate...
  22. Aşık E, Aslan T, Volkan M, Güray N. 2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells. Environ Toxicol Pharmacol. 2016;41:272-8 pubmed publisher
    ..In addition, the gene expression levels of four drug-metabolizing enzymes, two Phase I (CYP1A1, CYP1B1) and two Phase II (GSTM3, GSTZ1) were also increased with the high concentrations of 2DG-MNPs.
  23. Zheng X, Ning C, Dong Y, Zhao P, Li J, Fan Z, et al. Quantitative proteome analysis of bovine mammary gland reveals protein dynamic changes involved in peak and late lactation stages. Biochem Biophys Res Commun. 2017;494:292-297 pubmed publisher
    ..We observed five new DEPs (AACS, DHCR7, GSTM3, SFRP1 and SFRP4) and nine functional well-studies known proteins (PLIN2, LPIN1, PLIN3, GSN, CD74, MMP2, SOD1, ..
  24. Lin J, Tu S, Chen L, Huang C, Chang H, Cheng T, et al. Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells. Breast Cancer Res Treat. 2018;172:45-59 pubmed publisher
    Glutathione S-transferase mu 3 (GSTM3) is an enzyme involving in the detoxification of electrophilic compounds by conjugation with glutathione...
  25. Gough A, Zhong S, Wolf C, Spurr N. Chromosome assignment of the human glutathione S-transferase mu 3 gene (GSTM3) to chromosome 1 by gene specific polymerase chain reaction. Cytogenet Cell Genet. 1994;65:111-4 pubmed
    Oligonucleotide primers specific for exons 4 and 5 sequences were used to amplify a unique 199-bp fragment in the human GSTM3 gene. Using DNA from a panel of somatic cell hybrids we assigned the GSTM3 locus to chromosome 1p.
  26. Matthias C, Jahnke V, Fryer A, Strange R. [Influence of glutathione s-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer]. Laryngorhinootologie. 2002;81:406-12 pubmed
    ..examined, in patients with squamous cell carcinoma (SCC) of the head and neck, associations between GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1 and CYP2E1 genotypes and outcome parameters, tumor extension, histological grade, presence ..
  27. De Roos A, Gold L, Wang S, Hartge P, Cerhan J, Cozen W, et al. Metabolic gene variants and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1647-53 pubmed
    ..associations between non-Hodgkin's lymphoma and 15 variants in AHR, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTP1, GSTM3, EPHX1, NQO1, and PON1...
  28. Patskovsky Y, Patskovska L, Listowsky I. An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Biochemistry. 1999;38:16187-94 pubmed
    ..The presence of a polar Asn212 in place of a Phe residue found in the cognate position of other mu class glutathione S-transferases, therefore, has a marked influence on catalysis by hGSTM3-3. ..
  29. Brind A, Hurlstone A, Edrisinghe D, Gilmore I, Fisher N, Pirmohamed M, et al. The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. Alcohol Alcohol. 2004;39:478-83 pubmed
    ..There were no significant differences in GSTM1, GSTM3 or GSTP1 genotype frequencies among patients, drinking and non-drinking controls from the three centres...
  30. Ye Z, Song H, Higgins J, Pharoah P, Danesh J. Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med. 2006;3:e91 pubmed
    ..studies of five GST polymorphisms (GSTM1 null, GSTT1 null, I105V, and A114V polymorphisms in the GSTP1 genes, and GSTM3 intron 6 polymorphism) available before August, 2005, with investigation of potential sources of heterogeneity...
  31. Dickinson S, Griffin B, Elmore M, Kriese Anderson L, Elmore J, Dyce P, et al. Transcriptome profiles in peripheral white blood cells at the time of artificial insemination discriminate beef heifers with different fertility potential. BMC Genomics. 2018;19:129 pubmed publisher
    ..heifers yielded 18 differentially expressed genes (DEGs) (ADAM20, ALDH5A1, ANG, BOLA-DQB, DMBT1, FCER1A, GSTM3, KIR3DL1, LOC107131247, LOC618633, LYZ, MNS1, P2RY12, PPP1R1B, SIGLEC14, TPPP, TTLL1, UGT8, eFDR?0.02)...
  32. Ljepoja B, García Román J, Sommer A, Frohlich T, Arnold G, Wagner E, et al. A proteomic analysis of an in vitro knock-out of miR-200c. Sci Rep. 2018;8:6927 pubmed publisher
    ..In six of these targets (AGR2, FLNA/B, ALDH7A1, SCIN, GSTM3) the differential expression was additionally detected at mRNA level...
  33. Maulvault A, Barbosa V, Alves R, Anacleto P, Camacho C, Cunha S, et al. Integrated multi-biomarker responses of juvenile seabass to diclofenac, warming and acidification co-exposure. Aquat Toxicol. 2018;202:65-79 pubmed publisher
    ..g. by further lowering erythrocyte viability, and increasing brain GST activity and Ub synthesis in muscle), the co-exposure to these abiotic stressors also resulted in a reversion/..
  34. Malik M, Upadhyay R, Mittal R, Zargar S, Modi D, Mittal B. Role of xenobiotic-metabolizing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in Kashmir Valley. J Gastrointest Cancer. 2009;40:26-32 pubmed publisher
    ..303 subjects (108 GC and 195 healthy controls) to analyze the association of polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3, CYP1A1, and CYP2E1 genes in susceptibility to GC in Kashmir Valley...
  35. Qi L, Zou Z, Wang L, Gao S, Fan Y, Long B, et al. Methylation of the glutathione-S-transferase M3 gene promoter is associated with oxidative stress in acute-on-chronic hepatitis B liver failure. Tohoku J Exp Med. 2012;228:43-51 pubmed
    ..The present study was aimed to determine the potential association between GSTM3 promoter methylation and oxidative stress in ACHBLF patients...
  36. Mace K, Bowman E, Vautravers P, Shields P, Harris C, Pfeifer A. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur J Cancer. 1998;34:914-20 pubmed
    ..showed that GSTM1 was expressed in 40% of the bronchial mucosa and 25% of the peripheral lung tissues, whereas GSTM3 and NAT1 mRNAs were found in all bronchial and lung samples...
  37. Garcia Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein D, et al. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet. 2005;366:649-59 pubmed
    ..We investigated polymorphisms in NAT2, GSTM1, NAT1, GSTT1, GSTM3, and GSTP1 in 1150 patients with transitional-cell carcinoma of the urinary bladder and 1149 controls in Spain; ..
  38. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis. 2008;29:1164-9 pubmed publisher
    ..Moreover, significant associations with multiple SNPs in the phase II genes ALDH2, COMT, EPHX1, SOD2, NAT1, NAT2, GSTM3, GSTP1, GSTT2 and MPO were also found...
  39. Maes O, Schipper H, Chong G, Chertkow H, Wang E. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Neurobiol Aging. 2010;31:34-45 pubmed publisher
    Brain-specific glutathione S-transferase Mu 3 (GSTM3) colocalizes with amyloid-beta plaques in Alzheimer's disease (AD). A functional polymorphism rs7483 in GSTM3 may contribute to the decrease in GSTM3 expression in AD...
  40. Shawahna R, Uchida Y, Declèves X, Ohtsuki S, Yousif S, Dauchy S, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm. 2011;8:1332-41 pubmed publisher
    ..CYP1B1 and CYP2U1 were the only quantifiable CYPs. Finally, GSTP1, COMT, GSTM3, GSTO1 and GSTM2 proteins were the main phase II enzymes quantified; UGTs and NATs were not detected...
  41. Tatemichi M, Iwasaki M, Sasazuki S, Tsugane S. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. J Hum Genet. 2009;54:557-63 pubmed publisher
    ..pylori. GST-M3 activity is possibly involved in protection against mucosal atrophy caused by H. pylori as the levels of IgG titer and PGI are linked to mucosal status. ..
  42. Glisic B, Mihaljević I, Popovic M, Zaja R, Loncar J, Fent K, et al. Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquat Toxicol. 2015;158:50-62 pubmed publisher
    ..Affinity toward CDNB varied from 0.28 mM (Gstp2) to 3.69 mM (Gstm3), while affinity toward MCB was in the range of 5 μM (Gstt1a) to 250 μM (Gstp1)...
  43. Malik M, Upadhyay R, Mittal R, Zargar S, Mittal B. Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. Nutr Cancer. 2010;62:734-42 pubmed publisher
    ..association of polymorphisms in glutathione S-transferase (GST) mu (GSTM1), GST theta (GSTT1), GST pi (GSTP1), GSTM3, Cytochrome P450 (CYP)1A1, and CYP2E1 genes with susceptibility to EC as well as their interaction with ..
  44. Ni W, Ji J, Dai Z, Papp A, Johnson A, Ahn S, et al. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS ONE. 2010;5:e13792 pubmed publisher
    ..This study aimed to evaluate pharmacogenetic factors associated with inter-individual variability in pharmacokinetics and outcomes associated with flavopiridol therapy...
  45. Wang Z, Xu H, He M, Wu H, Zhu Y, Su Z. The association of glutathione S-transferase polymorphisms in patients with osteosarcoma: evidence from a meta-analysis. Eur J Cancer Care (Engl). 2015;24:417-24 pubmed publisher
    ..We found that there was significant association between the polymorphisms in GSTT1 or GSTM3 (AA versus BB) and osteosarcoma risk...
  46. Jiang X, Chang F, Bai T, Lv X, Wang M. Susceptibility of lung cancer with polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 genotypes in the population of Inner Mongolia region. Asian Pac J Cancer Prev. 2014;15:5207-14 pubmed
    To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China...
  47. Anttila S, Hirvonen A, Vainio H, Husgafvel Pursiainen K, Hayes J, Ketterer B. Immunohistochemical localization of glutathione S-transferases in human lung. Cancer Res. 1993;53:5643-8 pubmed
    ..GSTM2, a striated muscle-specific isozyme, occurred minimally in the epithelium of the terminal airways, and GSTM3, an enzyme of broad extrahepatic occurrence, was observable in the ciliated airway epithelium and smooth muscle of ..
  48. Pearson W, Vorachek W, Xu S, Berger R, Hart I, Vannais D, et al. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet. 1993;53:220-33 pubmed
    The GSTM1, GSTM2, GSTM3, GSTM4, and GSTM5 glutathione transferase genes have been mapped to human chromosome 1 by using locus-specific PCR primer pairs spanning exon 6, intron 6, and exon 7, as probes on DNA from human/hamster somatic ..
  49. Reszka E, Wasowicz W, Gromadzinska J. Antioxidant defense markers modulated by glutathione S-transferase genetic polymorphism: results of lung cancer case-control study. Genes Nutr. 2007;2:287-94 pubmed publisher
    ..In control subjects with GSTM3*A/*A, GSTT1 null, GSTM1 null + GSTT1 null, GSTM3*A/*A + GSTT1 null genotype, glutathione peroxidase activity was ..
  50. Wang S, Chanock S, Tang D, Li Z, Edwards S, Jedrychowski W, et al. Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Ann Hum Genet. 2010;74:46-56 pubmed publisher
    ..The strongest and most consistent effect observed was between PAH and haplotype ACCGGC of the CYP1B1 gene. ..
  51. Chu G, Li Y, Dong X, Liu J, Zhao Y. Role of NSD1 in H2O2-induced GSTM3 suppression. Cell Signal. 2014;26:2757-64 pubmed publisher
    ..In the present study, we focused on the NSD1 regulation of antioxidant enzyme gene glutathione S-transferase M3 (GSTM3) expression in response to oxidative stress...
  52. Raychaudhuri U, Millar J, Clark A. Tissue Transglutaminase Elevates Intraocular Pressure in Mice. Invest Ophthalmol Vis Sci. 2017;58:6197-6211 pubmed publisher
    ..b>GTM3, primary human GTM 125-05, and cultured mouse TM cells were transduced with adenovirus serotype 5 expressing human ..
  53. Rowe J, Nieves E, Listowsky I. Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Biochem J. 1997;325 ( Pt 2):481-6 pubmed
    ..Acetylation of N-terminal residues in the GSTA1, GSTA2, GSTM3 and GSTM4 subunits were the only natural post-translational modifications detected...
  54. Lan Q, Chow W, Lissowska J, Hein D, Buetow K, Engel L, et al. Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland. Pharmacogenetics. 2001;11:655-61 pubmed
    ..97-2.25) in patients with the GSTT1 null genotype but no evidence of increased risk associated with the GSTM1, GSTM3 or GSTP1 genotypes...
  55. Liu Y, Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, et al. Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. J Hum Genet. 2005;50:62-8 pubmed
    ..GSTT2, ALDH2, NOS2A, OGG1, and SLC6A4 and those of odds ratios to habitual drinking for CYP1B1, ESR1, HSD17B3, GSTM3, COMT, ADH1C, ALDH2, NOS3, and NUDT1 were under 0.05...
  56. Tran A, Jullien V, Alexandre J, Rey E, Rabillon F, Girre V, et al. Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms. Clin Pharmacol Ther. 2006;79:570-80 pubmed
    Patients initiating docetaxel chemotherapy were genotyped for CYP3A4, CYP3A5, MDR1, GSTM1, GSTT1, GSTM3, and GSTP1 to identify variability factors of docetaxel pharmacokinetics and toxicity...
  57. Canova C, Richiardi L, Merletti F, Pentenero M, Gervasio C, Tanturri G, et al. Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy. Tumori. 2010;96:1-10 pubmed
    ..The study of single nucleotide polymorphisms in upper aerodigestive tract cancer etiology may help to identify high-risk subgroups and to better understand the pathways leading to the development of these cancers...
  58. Tan X, Wang Y, Han Y, Chang W, Su T, Hou J, et al. Genetic variation in the GSTM3 promoter confer risk and prognosis of renal cell carcinoma by reducing gene expression. Br J Cancer. 2013;109:3105-15 pubmed publisher
    Glutathione S-transferase mu 3 (GSTM3) has been proven to be downregulated in renal cell carcinoma (RCC). We aimed to characterise the role of GSTM3 and its genetic predisposition on the occurrence and postoperative prognosis of RCC...
  59. Bogaards J, Van Ommen B, van Bladeren P. Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea. Biochem J. 1992;286 ( Pt 2):383-8 pubmed
    ..Pancreas and trachea contained predominantly the Pi-class subunit, P1. GST in the testis was mostly of the Mu class. The major subunit was M4, and subunits M2 and M3 were exclusively detected in the testis. ..
  60. Peters U, Preisler Adams S, Hebeisen A, Hahn M, Seifert E, Lanvers C, et al. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000;11:639-43 pubmed
    ..are null (GSTM1 and GSTT1), encode low-activity variants (GSTP1) or are associated with variable inducibility (GSTM3)...
  61. Ladero J, Martinez C, Fernández J, Martín F, Garcia Martin E, Ropero P, et al. Glutathione S-transferases pi 1, alpha 1 and M3 genetic polymorphisms and the risk of hepatocellular carcinoma in humans. Pharmacogenomics. 2007;8:895-9 pubmed
    ..GSTA1*B promoter allele, GSTM3*B 3-bp-deleted allele and GSTP1 Ile105Val SNP were identified...
  62. Delles C, Padmanabhan S, Lee W, Miller W, McBride M, McClure J, et al. Glutathione S-transferase variants and hypertension. J Hypertens. 2008;26:1343-52 pubmed publisher
    ..We identified two major linkage disequilibrium blocks including GSTM4/GSTM2 and GSTM5/GSTM3 separated by the GSTM1 gene...
  63. Khrunin A, Moisseev A, Gorbunova V, Limborska S. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Pharmacogenomics J. 2010;10:54-61 pubmed publisher
    ..044). Thrombocytopenia, anemia and neuropathy were less frequent among patients with the GSTM1-null or GSTM3 intron 6 AGG/AGG genotypes...
  64. Bracalente C, Ibañez I, Berenstein A, Notcovich C, Cerda M, Klamt F, et al. Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. Oncotarget. 2016;7:41154-41171 pubmed publisher
    ..Moreover, differential coexpression of AOS genes (EPHX2, GSTM3, MGST1, MSRA, TXNRD3, MGST3 and GSR) was found in A7 and G10...
  65. Li B, Zhou J, Zhang G, Wang Y, Kang L, Wu J, et al. Relationship Between the Altered Expression and Epigenetics of GSTM3 and Age-Related Cataract. Invest Ophthalmol Vis Sci. 2016;57:4721-32 pubmed publisher
    Glutathione S-Transferase Mu 3 (GSTM3) protects the lens from oxidative stress that contributes to age-related cataract (ARC) formation...
  66. Shiota M, Fujimoto N, Itsumi M, Takeuchi A, Inokuchi J, Tatsugami K, et al. Gene polymorphisms in antioxidant enzymes correlate with the efficacy of androgen-deprivation therapy for prostate cancer with implications of oxidative stress. Ann Oncol. 2017;28:569-575 pubmed publisher
    ..In metastatic prostate cancer, the AG/GG allele in GSTM3 rs7483 and CT/TT allele in CAT rs564250 were associated with a significantly lower risk of progression to CRPC and ..
  67. Banerjee J, Leung C, Li A, Peterson Yantorno K, Ouyang H, Stamer W, et al. Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2017;58:492-501 pubmed publisher
    ..Primary TM cell cultures and the TM5 and GTM3 cell lines expressed Ano6 3 to 4 orders of magnitude higher than the other anoctamin CaCCs (Ano1 and Ano2)...
  68. Shawahna R, Ganeshamoorthy K, Huilong L, Scherrmann J, Couraud P, Declèves X. Effect of Long-term In Vitro Lithium Exposure on mRNA Levels of Claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC/D3 Human Brain Endothelial Cell Line. Eur J Drug Metab Pharmacokinet. 2017;42:1013-1017 pubmed publisher
    ..protein claudin-3, the ABC transporter BCRP/ABCG2, the cytochrome P-450 CYP1A1 and the glutathione-S-transferase GSTM3, while the other selected markers were not significantly affected...
  69. Alkharashi N, Periasamy V, Athinarayanan J, Alshatwi A. Cadmium triggers mitochondrial oxidative stress in human peripheral blood lymphocytes and monocytes: Analysis using in vitro and system toxicology approaches. J Trace Elem Med Biol. 2017;42:117-128 pubmed publisher
    ..Dose-dependent upregulation of GSTM3 and downregulation of GSR gene expression were observed...
  70. Loft S, Svoboda P, Kasai H, Tjønneland A, Møller P, Sørensen M, et al. Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases. Int J Cancer. 2007;121:1579-84 pubmed
    ..Effect modification by glutathione-S-transferases GSTM1, GSTM3, GSTT1 and GSTP1 was investigated...
  71. Salinas Souza C, Petrilli A, de Toledo S. Glutathione S-transferase polymorphisms in osteosarcoma patients. Pharmacogenet Genomics. 2010;20:507-15 pubmed publisher
    ..This study aims to investigate the genotype frequencies of GSTM1, GSTT1 and GSTM3 genes in 80 osteosarcoma patients and 160 normal control participants, and also the influence of these ..
  72. León Cachón R, Ascacio Martínez J, Gamino Peña M, Cerda Flores R, Meester I, Gallardo Blanco H, et al. A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers. BMC Cancer. 2016;16:74 pubmed publisher
    ..polymorphisms were found to have a significant effect on ATV pharmacokinetics: MTHFR (rs1801133), DRD3 (rs6280), GSTM3 (rs1799735), TNFα (rs1800629), MDR1 (rs1045642), and SLCO1B1 (rs4149056)...
  73. Zhao Q, Yang R, Wang J, Hu D, Li F. PPAR? activation protects against cholestatic liver injury. Sci Rep. 2017;7:9967 pubmed publisher hepatic cell resulted in the enhanced expression of anti-oxidative genes glutathione S-transferases (Gsta2 and Gstm3) directly...
  74. Landi S, Gemignani F, Neri M, Barale R, Bonassi S, Bottari F, et al. Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma. Int J Cancer. 2007;120:2739-43 pubmed
    ..No effect was found for GSTA2, GSTA4, GSTM3, GSTP1 and GSTT1 genes...
  75. Wang B, Zhang S, Wang X, Yang S, Jiang Q, Xu Y, et al. Transcriptome analysis of the effects of chitosan on the hyperlipidemia and oxidative stress in high-fat diet fed mice. Int J Biol Macromol. 2017;102:104-110 pubmed publisher
    ..Transcriptome analysis indicated that increased Mups, Lcn2, Gstm3 and CYP2E1 expressions clearly indicated HFD induced lipid metabolism disorder and oxidative damage...
  76. Rowe J, Patskovsky Y, Patskovska L, Novikova E, Listowsky I. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis. J Biol Chem. 1998;273:9593-601 pubmed
    ..The identification of this unique mammalian GST subclass could advance strategies for interspecies comparisons of GSTs and provides a rodent model for studies on functions and regulatory mechanisms for human GSTs. ..
  77. Liu J, Li M, Qi M, Liu X, Li Y, Fu L, et al. [Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24:582-5 pubmed
    To investigate the distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension (EH)...
  78. White D, Li D, Nurgalieva Z, El Serag H. Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol. 2008;167:377-89 pubmed
    ..eligible studies were identified: 14 evaluated GSTM1; 13, GSTT1; three, GSTP1; and one each evaluated GSTM2, GSTM3, GSTA1, GSTA4, GSTO1, and GSTO2, respectively...
  79. Singh H, Sachan R, Devi S, Pandey S, Mittal B. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Am J Obstet Gynecol. 2008;198:303.e1-6 pubmed publisher
    The objective of the study was to evaluate the influence of genetic polymorphisms of GSTM1, GSTT1, and GSTM3 on the susceptibility of cervical cancer...
  80. Eriksen K, Sørensen M, Autrup H, Vogel U, Overvad K, Tjønneland A, et al. Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. J Toxicol Environ Health A. 2010;73:583-95 pubmed publisher
    ..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population. ..
  81. Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I. A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. J Biol Chem. 1990;265:9188-93 pubmed
    ..Distinct catalytic and structural properties of the testis-brain mu-class GSTs suggest that these GSTs may be uniquely involved in blood-barrier functions common to both organs. ..
  82. Medeiros R, Vasconcelos A, Costa S, Pinto D, Ferreira P, Lobo F, et al. Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms. Prostate. 2004;58:414-20 pubmed
    ..Genetic polymorphisms have been reported in GSTM1, GSTM3, and GSTT1 with functional alterations and influencing cancer risk...
  83. Martinez C, Martín F, Fernández J, Garcia Martin E, Sastre J, Diaz Rubio M, et al. Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. Pharmacogenomics. 2006;7:711-8 pubmed
    ..GST mu1 (GSTM1), theta1 (GSTT1), pi1 (GSTP1), alpha1 (GSTA1) and mu3 (GSTM3) genotypes were determined in 144 colorectal cancer patients, 98 gastric cancer patients and 329 healthy control ..
  84. Zhang Y, Hughes K, Zahm S, Zhang Y, Holford T, Dai L, et al. Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma. Am J Epidemiol. 2009;170:1222-30 pubmed publisher
    ..0, 95% CI: 1.2, 3.4), a homozygous or heterozygous 3-base-pair deletion in intron 6 of GSTM3 (OR = 2.3, 95% CI: 1.3, 4.1), GSTP1 Ex5-24A>G AA genotypes (OR = 1.8, 95% CI: 1.1, 2...
  85. Bullock J, Medway C, Cortina Borja M, Turton J, Prince J, Ibrahim Verbaas C, et al. Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease. Neurobiol Aging. 2013;34:1309.e1-7 pubmed publisher
    ..We found an epistatic interaction, between rs7483 in GSTM3 and rs1111875 in the HHEX/IDE/KIF11 gene cluster, with a closely similar, significant result in both datasets...
  86. Pervan C, Lautz J, Blitzer A, Langert K, Stubbs E. Rho GTPase signaling promotes constitutive expression and release of TGF-β2 by human trabecular meshwork cells. Exp Eye Res. 2016;146:95-102 pubmed publisher
    ..Consistent with this thesis, cultured primary or transformed (GTM3) quiescent human TM cells were found to constitutively express and secrete measurable amounts of biologically-..
  87. Yang G, Ross D, Kuang W, Brown P, Weigel R. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 1999;27:1517-23 pubmed
    ..This approach allowed the identification of differentially expressed genes without the need to obtain previously cloned cDNAs. ..
  88. Yin S, Li X, Meng Y, Finley R, Sakr W, Yang H, et al. Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. J Biol Chem. 2005;280:34985-96 pubmed
  89. Satoh J, Nanri Y, Yamamura T. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. J Neurosci Methods. 2006;152:278-88 pubmed
    ..These results suggest that protein microarray is a powerful tool for rapid and comprehensive profiling of 14-3-3-binding proteins. ..
  90. Lira M, Provezza L, Malerba G, Naldi L, Remuzzi G, Boschiero L, et al. Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients. Exp Dermatol. 2006;15:958-65 pubmed
    ..We investigated the frequency of GST genotypes (GSTM1, GSTM3, GSTT1 and GSTP1) and CYP1A1 in 239 transplant recipients: 107 cases with NMSC and 132 controls free from NMSC ..
  91. Hong G, Heun R, Jessen F, Popp J, Hentschel F, Kelemen P, et al. Gene variations in GSTM3 are a risk factor for Alzheimer's disease. Neurobiol Aging. 2009;30:691-6 pubmed
    ..relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD...
  92. Broberg K, Tinnerberg H, Axmon A, Warholm M, Rannug A, Littorin M. Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study. Environ Health. 2008;7:15 pubmed publisher
    ..and a non-exposed group (N = 114) were analyzed for genotype (metabolising genes: CYP1A1*2A, CYP1A1*2B, GSTM1*O, GSTM3*B, GSTP1 I105V, GSTP1 A114V, GSTT1*O, MPO -463, NAT1*3, *4, *10, *11, *14, *15, NAT2*5, *6, *7, SULT1A1 R213H; ..