GSDMA

Summary

Gene Symbol: GSDMA
Description: gasdermin A
Alias: FKSG9, GSDM, GSDM1, gasdermin-A, gasdermin-1
Species: human
Products:     GSDMA

Top Publications

  1. Crosslin D, McDavid A, Weston N, Nelson S, Zheng X, Hart E, et al. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet. 2012;131:639-52 pubmed publisher
    ..the EA subjects, we identified significantly associated SNPs tagging three separate genes in the 17q21 region: (1) GSDMA, (2) MED24, and (3) PSMD3...
  2. Saeki N, Usui T, Aoyagi K, Kim D, Sato M, Mabuchi T, et al. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer. 2009;48:261-71 pubmed publisher
    Gasdermin (GSDM or GSDMA), expressed in the upper gastrointestinal tract but frequently silenced in gastric cancers (GCs), regulates apoptosis of the gastric epithelium...
  3. Glisovic S, Pastore Y, Gagné V, Plesa M, Laverdiere C, Leclerc J, et al. Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity. Pharmacogenomics J. 2018;18:270-274 pubmed publisher
    ..Recent genome-wide association studies identified variants in DARC and CXCL2 genes, and in ORMDL3-GSDMA-CSF3 locus on chromosome 17q21 that influence white blood cell and neutrophil counts in healthy individuals...
  4. . Improving Diversity of Dental Students Through the Boston University Master's of Oral Health Sciences Postbaccalaureate Program. J Dent Educ. 2019;83:287-295 pubmed publisher
    Boston University Goldman School of Dental Medicine (GSDM), in collaboration with Boston University School of Medicine, introduced the Oral Health Sciences (OHS) pipeline program in 2005 to enhance the academic preparedness of students ..
  5. Yang J, Wei X, Tufan T, Kuscu C, Unlu H, Farooq S, et al. Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer. Genome Biol. 2018;19:190 pubmed publisher
    ..Through CRISPR interference, we find that the recurrently mutated regulatory element at the LRRC3C-GSDMA locus impacts the expression of multiple distal genes...
  6. Mitra S, Sarkar A. Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1β release. Purinergic Signal. 2019;15:119-123 pubmed publisher
    ..Gasdermin-D (GSDM-D), a protein involved in pyroptosis and inflammasome activation, has been recently described to be involved in the ..
  7. Chen S, Mei S, Luo Y, Wu H, Zhang J, Zhu J. Gasdermin Family: a Promising Therapeutic Target for Stroke. Transl Stroke Res. 2018;9:555-563 pubmed publisher
    ..Gasdermin (GSDM) family is a series of recently discovered proteins, which acts as the executor of pyroptosis and protagonist of ..
  8. Hergueta Redondo M, Sarrió D, Molina Crespo Ã, Megias D, Mota A, Rojo Sebastián A, et al. Gasdermin-B promotes invasion and metastasis in breast cancer cells. PLoS ONE. 2014;9:e90099 pubmed publisher
    Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D)...
  9. Feng S, Fox D, Man S. Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death. J Mol Biol. 2018;430:3068-3080 pubmed publisher
    The Gasdermin (GSDM) family consists of Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME) and Pejvakin (PJVK). GSDMD is activated by inflammasome-associated inflammatory caspases...

More Information

Publications37

  1. Shi P, Tang A, Xian L, Hou S, Zou D, Lv Y, et al. Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J. 2015;468:325-36 pubmed publisher
    ..Studies on other members of the GSDM family suggested this mechanism is conserved in several sub-families.
  2. Stein M, Thompson E, Schoettler N, Helling B, Magnaye K, Stanhope C, et al. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018;142:749-764.e3 pubmed publisher
    ..and gasdermin B (GSDMB), making these prime candidate asthma genes, although recent studies have implicated gasdermin A (GSDMA) distal to and post-GPI attachment to proteins 3 (PGAP3) proximal to the core region as independent ..
  3. Lin P, Lin H, Kuo C, Yang L. N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. J Biomed Sci. 2015;22:44 pubmed publisher
    ..Gene mutations that disturb this turnover process may cause skin diseases. Human GASDERMIN A (GSDMA) is frequently silenced in gastric cancer cell lines and its overexpression has been reported to induce ..
  4. Mitra S, Exline M, Habyarimana F, Gavrilin M, Baker P, Masters S, et al. Microparticulate Caspase-1 Regulates Gasdermin-D and Pulmonary Vascular Endothelial Cell Injury. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
    ..Because GSDM-D mediates pyroptotic death and is essential for pore formation, we hypothesized that it may direct caspase-1 ..
  5. Qiu S, Liu J, Xing F. 'Hints' in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death. Cell Death Differ. 2017;24:588-596 pubmed publisher
    ..features and functions of the novel player proteins in cell death, including GSDMD triggering pyroptosis, Gsdma3/GSDMA initiating autophagy/apoptosis and DFNA5 inducing apoptosis/secondary necrosis...
  6. Zavbi M, Korosec P, Flezar M, Škrgat Kristan S, Marc Malovrh M, Rijavec M. Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients. Hum Immunol. 2016;77:527-34 pubmed publisher
    ..Single SNP analysis revealed only marginal associations with adult asthma for SNPs located in GSDMA, GSDMB, ORMDL3 and ZPBP2 genes, and rs7219080 was the most highly associated...
  7. Tamura M, Shiroishi T. GSDM family genes meet autophagy. Biochem J. 2015;469:e5-7 pubmed publisher
    In the previous issue of Biochemical Journal, Shi et al. [(2015) 468, 325-336] report that Gasdermin (Gsdm) family proteins regulate autophagy activity, which is counter-balanced by the opposite functions of well-conserved N- and C-..
  8. Aglietti R, Dueber E. Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions. Trends Immunol. 2017;38:261-271 pubmed publisher
    ..We further discuss the implications for the rest of the gasdermin (GSDM) family, which are emerging as mediators of programmed cell death in a variety of processes that regulate cellular ..
  9. Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 2016;535:111-6 pubmed publisher
    ..Here we show that the gasdermin-N domains of the gasdermin proteins GSDMD, GSDMA3 and GSDMA can bind membrane lipids, phosphoinositides and cardiolipin, and exhibit membrane-disrupting cytotoxicity in ..
  10. Sarnowski C, Sugier P, Granell R, Jarvis D, Dizier M, Ege M, et al. Identification of a new locus at 16q12 associated with time to asthma onset. J Allergy Clin Immunol. 2016;138:1071-1080 pubmed publisher
    ..1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA])...
  11. Alrqiq H, Scott T, Mascarenhas A. Evaluating a Cultural Competency Curriculum: Changes in Dental Students' Perceived Awareness, Knowledge, and Skills. J Dent Educ. 2015;79:1009-15 pubmed
    ..Goldman School of Dental Medicine (GSDM)...
  12. Katoh M, Katoh M. Identification and characterization of human ZPBP-like gene in silico. Int J Mol Med. 2003;12:399-404 pubmed
    ..The MGC9753-ERBB2-MGC14832-GRB7-ZNFN1A3-ZPBPL-PRO2521-ORMDL3-GSDM locus on human chromosome 17q12-q21 and the ZPBP-ZNFN1A1-FIGNL1-DDC-GRB10-COBL-SEC61G-EGFR-LANCL2 locus on human ..
  13. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome. 2000;11:718-24 pubmed
    ..Thus, we named the mouse gene Gasdermin (Gsdm). This is the first report of a mammalian gene whose expression is restricted to both upper GI tract and skin...
  14. Zihlif M, Obeidat N, Zihlif N, Mahafza T, Froukh T, Ghanim M, et al. Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians. Genet Test Mol Biomarkers. 2016;20:143-8 pubmed publisher
    b>Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood, and to a lesser extent with adult, asthma in many populations...
  15. Bønnelykke K, Sleiman P, Nielsen K, Kreiner Møller E, Mercader J, Belgrave D, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014;46:51-5 pubmed publisher
    ..These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes. ..
  16. Moffatt M, Gut I, Demenais F, Strachan D, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363:1211-1221 pubmed publisher
    ..Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma. (Funded by the European Commission and others.) ..
  17. Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics. 2007;89:618-29 pubmed
    Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants...
  18. Al Tuwaijri A, Gagné Ouellet V, Madore A, Laprise C, Naumova A. Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population. J Med Genet. 2016;53:232-41 pubmed publisher
    ..22 (organic 3 cation/carnitine transporter) member 5 (SLC22A5), zona pellucida binding protein 2 (ZPBP2) and gasdermin A (GSDMA) promoter regions...
  19. Ferreira M, Matheson M, Tang C, Granell R, Ang W, Hui J, et al. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol. 2014;133:1564-71 pubmed publisher
    ..was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP...
  20. Lachner J, Mlitz V, Tschachler E, Eckhart L. Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes. Sci Rep. 2017;7:17446 pubmed publisher
    ..and pyrin domain-containing 1 (PYDC1), the anti-inflammatory IL1F members IL-37 (IL1F7) and IL-38 (IL1F10), and GSDMA, were strongly induced in differentiated keratinocytes...
  21. Lluis A, Schedel M, Liu J, Illi S, Depner M, von Mutius E, et al. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol. 2011;127:1587-94.e6 pubmed publisher
    ..Gene expression was assessed for ORMDL3; gasdermin A (GSDMA, alias GSDM1); gasdermin B (GSDMB, alias GSDML); Ikaros family zinc finger 3 (ZNFN1A3), zona pellucida ..
  22. Saeki N, Kim D, Usui T, Aoyagi K, Tatsuta T, Aoki K, et al. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene. 2007;26:6488-98 pubmed
    ..We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lines...
  23. Moussette S, Al Tuwaijri A, Kohan Ghadr H, Elzein S, Farias R, Berube J, et al. Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PLoS ONE. 2017;12:e0172707 pubmed publisher
    ..pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB)...
  24. Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, et al. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis. 2017;76:1150-1158 pubmed publisher
    ..We identified two significant SNP in two loci, GSDMA and PRDM1, both of which are related to immune functions and associated with other autoimmune diseases (..
  25. Das S, Miller M, Broide D. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases. Adv Immunol. 2017;135:1-52 pubmed publisher
    ..GSDMB is one of four members of the GSDM family (GSDMA, GSDMB, GSDMC, and GSDMD)...
  26. Yu J, Kang M, Kim B, Kwon J, Song Y, Choi W, et al. Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr Pulmonol. 2011;46:701-8 pubmed publisher
    The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2...
  27. Söderman J, Berglind L, Almer S. Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility. Biomed Res Int. 2015;2015:834805 pubmed publisher
    ..1 × 10(-3)-7.2 × 10(-10)). The susceptibility allele was also associated with the increased expression of GSDMA (P = 1.6 × 10(-4)) and LRRC3C (P = 7...
  28. Katoh M, Katoh M. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Int J Oncol. 2004;24:757-63 pubmed
    ..Here, we compared human GSDML-GSDM locus with rodent genomes by using bioinformatics. Rodent ortholog of human GSDML was not identified...