Gene Symbol: GRPEL1
Description: GrpE like 1, mitochondrial
Alias: GrpE, HMGE, mt-GrpE#1, grpE protein homolog 1, mitochondrial, GrpE-like protein cochaperone
Konovalova S, Liu X, Manjunath P, Baral S, Neupane N, Hilander T, et al
. Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone. Redox Biol. 2018;19:37-45 pubmed publisher
..Vertebrates have two mitochondrial GrpE paralogs, GRPEL1 and 2, but without clearly defined roles...
Allu P, Boggula Y, Karri S, Marada A, Krishnamoorthy T, Sepuri N. A conserved R type Methionine Sulfoxide Reductase reverses oxidized GrpEL1/Mge1 to regulate Hsp70 chaperone cycle. Sci Rep. 2018;8:2716 pubmed publisher
..and the conservation of the reversible methionine oxidation mechanism in higher eukaryotes is debatable as human GrpEL1 (hGrpEL1) unlike its homolog yMge1 harbors two methionine residues and multiple cysteines besides the mammalian ..
Marada A, Allu P, Murari A, Pullareddy B, Tammineni P, Thiriveedi V, et al
. Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function. Mol Biol Cell. 2013;24:692-703 pubmed publisher
..This novel oxidative sensor capability of yeast Mge1 might represent an evolutionarily conserved function, given that human recombinant dimeric Mge1 is also sensitive to H2O2...
Srivastava S, Savanur M, Sinha D, Birje A, R V, Saha P, et al
. Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells. J Biol Chem. 2017;292:18075-18090 pubmed publisher
..Here, we report that two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, modulate mtHsp70's function in human cells...
Choglay A, Chapple J, Blatch G, Cheetham M. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Gene. 2001;267:125-34 pubmed
..coli Hsp70 co-chaperone GrpE and designated it HMGE...
Borges J, Fischer H, Craievich A, Hansen L, Ramos C. Free human mitochondrial GrpE is a symmetric dimer in solution. J Biol Chem. 2003;278:35337-44 pubmed
The co-chaperone GrpE is essential for the activities of the Hsp70 system, which assists protein folding...